                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> METHODS AND COMPOSITIONS RELATING TO THE TREATMENT OF CANCER

<130> 043214-076692-PCT

<140>
<141>

<150> 61/814,441
<151> 2013-04-22

<150> 61/766,325
<151> 2013-02-19

<160> 39    

<170> PatentIn version 3.5

<210> 1
<211> 5616
<212> DNA
<213> Homo sapiens

<400> 1
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210> 2
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210> 3
<211> 4145
<212> DNA
<213> Homo sapiens

<400> 3
caaacaagtg cggccatttc accagcccag gctggcttct gctgttgact ggctgtggca       60

cctcaagcag cccctttccc ctctagcctc agtttatcac cgcaagagct accattcatc      120

tagcacaacc tgaccatcct cacactggtc agttccaacc ttcccaggaa tcttctgtgg      180

ccatgttcac tccggtttta cagaacagag aacagaagct cagagaagtg aagcaacttg      240

cccagctatg agagacagag ccaggatttg aaaccagatg aggacgctga ggcccagaga      300

gggaaagcca cttgcctagg gacacacagc ggggagaggt ggagcagggc ctctatttcg      360

agacccctga ctccacacct ggtgtttgtg ccaagacccc aggctgcctc ccaggtcctc      420

tgggacagcc cctgccttct accaggacca tgggtagcaa caagagcaag cccaaggatg      480

ccagccagcg gcgccgcagc ctggagcccg ccgagaacgt gcacggcgct ggcgggggcg      540

ctttccccgc ctcgcagacc cccagcaagc cagcctcggc cgacggccac cgcggcccca      600

gcgcggcctt cgcccccgcg gccgccgagc ccaagctgtt cggaggcttc aactcctcgg      660

acaccgtcac ctccccgcag agggcgggcc cgctggccgg tggagtgacc acctttgtgg      720

ccctctatga ctatgagtct aggacggaga cagacctgtc cttcaagaaa ggcgagcggc      780

tccagattgt caacaacaca gagggagact ggtggctggc ccactcgctc agcacaggac      840

agacaggcta catccccagc aactacgtgg cgccctccga ctccatccag gctgaggagt      900

ggtattttgg caagatcacc agacgggagt cagagcggtt actgctcaat gcagagaacc      960

cgagagggac cttcctcgtg cgagaaagtg agaccacgaa aggtgcctac tgcctctcag     1020

tgtctgactt cgacaacgcc aagggcctca acgtgaagca ctacaagatc cgcaagctgg     1080

acagcggcgg cttctacatc acctcccgca cccagttcaa cagcctgcag cagctggtgg     1140

cctactactc caaacacgcc gatggcctgt gccaccgcct caccaccgtg tgccccacgt     1200

ccaagccgca gactcagggc ctggccaagg atgcctggga gatccctcgg gagtcgctgc     1260

ggctggaggt caagctgggc cagggctgct ttggcgaggt gtggatgggg acctggaacg     1320

gtaccaccag ggtggccatc aaaaccctga agcctggcac gatgtctcca gaggccttcc     1380

tgcaggaggc ccaggtcatg aagaagctga ggcatgagaa gctggtgcag ttgtatgctg     1440

tggtttcaga ggagcccatt tacatcgtca cggagtacat gagcaagggg agtttgctgg     1500

actttctcaa gggggagaca ggcaagtacc tgcggctgcc tcagctggtg gacatggctg     1560

ctcagatcgc ctcaggcatg gcgtacgtgg agcggatgaa ctacgtccac cgggaccttc     1620

gtgcagccaa catcctggtg ggagagaacc tggtgtgcaa agtggccgac tttgggctgg     1680

ctcggctcat tgaagacaat gagtacacgg cgcggcaagg tgccaaattc cccatcaagt     1740

ggacggctcc agaagctgcc ctctatggcc gcttcaccat caagtcggac gtgtggtcct     1800

tcgggatcct gctgactgag ctcaccacaa agggacgggt gccctaccct gggatggtga     1860

accgcgaggt gctggaccag gtggagcggg gctaccggat gccctgcccg ccggagtgtc     1920

ccgagtccct gcacgacctc atgtgccagt gctggcggaa ggagcctgag gagcggccca     1980

ccttcgagta cctgcaggcc ttcctggagg actacttcac gtccaccgag ccccagtacc     2040

agcccgggga gaacctctag gcacaggcgg gcccagaccg gcttctcggc ttggatcctg     2100

ggctgggtgg cccctgtctc ggggcttgcc ccactctgcc tgcctgctgt tggtcctctc     2160

tctgtggggc tgaattgcca ggggcgaggc ccttcctctt tggtggcatg gaaggggctt     2220

ctggacctag ggtggcctga gagggcggtg ggtatgcgag accagcacgg tgactctgtc     2280

cagctcccgc tgtggccgca cgcctctccc tgcactccct cctggagctc tgtgggtctc     2340

tggaagagga accaggagaa gggctggggc cggggctgag ggtgcccttt tccagcctca     2400

gcctactccg ctcactgaac tccttcccca cttctgtgcc acccccggtc tatgtcgaga     2460

gctggccaaa gagcctttcc aaagaggagc gatgggcccc tggccccgcc tgcctgccac     2520

cctgcccctt gccatccatt ctggaaacac ctgtaggcag aggctgccga gacagaccct     2580

ctgccgctgc ttccaggctg ggcagcacaa ggccttgcct ggcctgatga tggtgggtgg     2640

gtgggatgag taccccctca aaccctgccc tccttagacc tgagggaccc ttcgagatca     2700

tcacttcctt gcccccattt cacccatggg gagacagttg agagcgggga tgtgacatgc     2760

ccaaggccac ggagcagttc agagtggagg cgggcttgga acccggtgct ccctctgtca     2820

tcctcaggaa ccaacaattc gtcggaggca tcatggaaag actgggacag cccaggaaac     2880

aaggggtctg aggatgcatt cgagatggca gattcccact gccgctgccc gctcagccca     2940

gctgttggga acagcatgga ggcagatgtg gggctgagct ggggaatcag ggtaaaaggt     3000

gcaggtgtgg agagagaggc ttcaatcggc ttgtgggtga tgtttgacct tcagagccag     3060

ccggctatga aagggagcga gcccctcggc tctggaggca atcaagcaga catagaagag     3120

ccaagagtcc aggaggccct ggtcctggcc tccttccccg tactttgtcc cgtggcattt     3180

caattcctgg ccctgttctc ctccccaagt cggcaccctt taactcatga ggagggaaaa     3240

gagtgcctaa gcgggggtga aagaggacgt gttacccact gccatgcacc aggactggct     3300

gtgtaacctt gggtggcccc tgctgtctct ctgggctgca gagtctgccc cacatgtggc     3360

catggcctct gcaactgctc agctctggtc caggccctgt ggcaggacac acatggtgag     3420

cctagccctg ggacatcagg agactgggct ctggctctgt tcggcctttg ggtgtgtggt     3480

ggattctccc tgggcctcag tgtgcccatc tgtaaagggg cagctgacag tttgtggcat     3540

cttgccaagg gtccctgtgt gtgtgtatgt gtgtgcatgt gtgcgtgtct ccatgtgcgt     3600

ccatatttaa catgtaaaaa tgtccccccc gctccgtccc ccaaacatgt tgtacatttc     3660

accatggccc cctcatcata gcaataacat tcccactgcc aggggttctt gagccagcca     3720

ggccctgcca gtggggaagg aggccaagca gtgcctgcct atgaaatttc aacttttcct     3780

ttcatacgtc tttattaccc aagtcttctc ccgtccattc cagtcaaatc tgggctcact     3840

caccccagcg agctctcaaa tccctctcca actgcctaag gccctttgtg taaggtgtct     3900

taatactgtc cttttttttt ttttaacagt gttttgtaga tttcagatga ctatgcagag     3960

gcctggggga cccctggctc tgggccgggc ctggggctcc gaaattccaa ggcccagact     4020

tgcggggggt gggggggtat ccagaattgg ttgtaaatac tttgcatatt gtctgattaa     4080

acacaaacag acctcagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4140

aaaaa                                                                 4145


<210> 4
<211> 536
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


<210> 5
<211> 4685
<212> DNA
<213> Homo sapiens

<400> 5
ggaggaggtg gagagtgagg ccgaggcgtg gggagcccgg gaactccctc ctcctgaagt       60

aacgcgtccc gggccggctc tgccgtcgtt gctgccgccg ggcgccccgg gacgaggagg      120

tggaggaggg agagggcccg cgggcctcgc ctccgccctc cgccacctcg agctgcggta      180

gcagcgactc atgagagcgc ggccggagga cagatttgat aatgggctgc attaaaagta      240

aagaaaacaa aagtccagcc attaaataca gacctgaaaa tactccagag cctgtcagta      300

caagtgtgag ccattatgga gcagaaccca ctacagtgtc accatgtccg tcatcttcag      360

caaagggaac agcagttaat ttcagcagtc tttccatgac accatttgga ggatcctcag      420

gggtaacgcc ttttggaggt gcatcttcct cattttcagt ggtgccaagt tcatatcctg      480

ctggtttaac aggtggtgtt actatatttg tggccttata tgattatgaa gctagaacta      540

cagaagacct ttcatttaag aagggtgaaa gatttcaaat aattaacaat acggaaggag      600

attggtggga agcaagatca atcgctacag gaaagaatgg ttatatcccg agcaattatg      660

tagcgcctgc agattccatt caggcagaag aatggtattt tggcaaaatg gggagaaaag      720

atgctgaaag attacttttg aatcctggaa atcaacgagg tattttctta gtaagagaga      780

gtgaaacaac taaaggtgct tattcccttt ctattcgtga ttgggatgag ataaggggtg      840

acaatgtgaa acactacaaa attaggaaac ttgacaatgg tggatactat atcacaacca      900

gagcacaatt tgatactctg cagaaattgg tgaaacacta cacagaacat gctgatggtt      960

tatgccacaa gttgacaact gtgtgtccaa ctgtgaaacc tcagactcaa ggtctagcaa     1020

aagatgcttg ggaaatccct cgagaatctt tgcgactaga ggttaaacta ggacaaggat     1080

gtttcggcga agtgtggatg ggaacatgga atggaaccac gaaagtagca atcaaaacac     1140

taaaaccagg tacaatgatg ccagaagctt tccttcaaga agctcagata atgaaaaaat     1200

taagacatga taaacttgtt ccactatatg ctgttgtttc tgaagaacca atttacattg     1260

tcactgaatt tatgtcaaaa ggaagcttat tagatttcct taaggaagga gatggaaagt     1320

atttgaagct tccacagctg gttgatatgg ctgctcagat tgctgatggt atggcatata     1380

ttgaaagaat gaactatatt caccgagatc ttcgggctgc taatattctt gtaggagaaa     1440

atcttgtgtg caaaatagca gactttggtt tagcaaggtt aattgaagac aatgaataca     1500

cagcaagaca aggtgcaaaa tttccaatca aatggacagc tcctgaagct gcactgtatg     1560

gtcggtttac aataaagtct gatgtctggt catttggaat tctgcaaaca gaactagtaa     1620

caaagggccg agtgccatat ccaggtatgg tgaaccgtga agtactagaa caagtggagc     1680

gaggatacag gatgccgtgc cctcagggct gtccagaatc cctccatgaa ttgatgaatc     1740

tgtgttggaa gaaggaccct gatgaaagac caacatttga atatattcag tccttcttgg     1800

aagactactt cactgctaca gagccacagt accagccagg agaaaattta taattcaagt     1860

agcctatttt atatgcacaa atctgccaaa atataaagaa cttgtgtaga ttttctacag     1920

gaatcaaaag aagaaaatct tctttactct gcatgttttt aatggtaaac tggaatccca     1980

gatatggttg cacaaaacca cttttttttc cccaagtatt aaactctaat gtaccaatga     2040

tgaatttatc agcgtatttc agggtccaaa caaaatagag ctaagatact gatgacagtg     2100

tgggtgacag catggtaatg aaggacagtg aggctcctgc ttatttataa atcatttcct     2160

ttcttttttt ccccaaagtc agaattgctc aaagaaaatt atttattgtt acagataaaa     2220

cttgagagat aaaaagctat accataataa aatctaaaat taaggaatat catgggacca     2280

aataattcca ttccagtttt ttaaagtttc ttgcatttat tattctcaaa agttttttct     2340

aagttaaaca gtcagtatgc aatcttaata tatgctttct tttgcatgga catgggccag     2400

gtttttcaaa aggaatataa acaggatctc aaacttgatt aaatgttaga ccacagaagt     2460

ggaatttgaa agtataatgc agtacattaa tattcatgtt catggaactg aaagaataag     2520

aactttttca cttcagtcct tttctgaaga gtttgactta gaataatgaa ggtaactaga     2580

aagtgagtta atcttgtatg aggttgcatt gattttttaa ggcaatatat aattgaaact     2640

actgtccaat caaaggggaa atgttttgat ctttagatag catgcaaagt aagacccagc     2700

attttaaaag ccctttttaa aaactagact tcgtactgtg agtattgctt atatgtcctt     2760

atggggatgg gtgccacaaa tagaaaatat gaccagatca gggacttgaa tgcacttttg     2820

ctcatggtga atatagatga acagagagga aaatgtattt aaaagaaata cgagaaaaga     2880

aagtgaaagt tttacaagtt agagggatgg aaggtaatgt ttaatgttga tgtcatggag     2940

tgacagaatg gctttgctgg cactcagagc tcctcactta gctatattct gagactttga     3000

agagttataa agtataacta taaaactaat ttttcttaca cactaaatgg gtatttgttc     3060

aaaataatga agttatggct tcacattcat tgcagtggga tatggttttt atgtaaaaca     3120

tttttagaac tccagttttc aaatcatgtt tgaatctaca ttcacttttt tttgttttct     3180

tttttgagac ggagtctcgc tctgtcgccc aggctggagt gcagtggcgc gatctcggct     3240

cactgcaagc tctgcctccc aggttcacac cattctcctg cctcagcctc ccgagtagct     3300

gggactacag gtgcccacca ccacgcctgg ctagtttttt gtatttttag tagagacgca     3360

gtttcaccgt gttagccagg atggtctcga tctcctgacc ttgtgatctg cccgcctcgg     3420

cctcccaaag tgctgggatt acaggcgtga gccaccgcgc ccagcctaca ttcacttcta     3480

aagtctatgt aatggtggtc attttttccc ttttagaata cattaaatgg ttgatttggg     3540

gaggaaaact tattctgaat attaacggtg gtgaaaaggg gacagttttt accctaaagt     3600

gcaaaagtga aacatacaaa ataagactaa tttttaagag taactcagta atttcaaaat     3660

acagatttga atagcagcat tagtggtttg agtgtctagc aaaggaaaaa ttgatgaata     3720

aaatgaaggt ctggtgtata tgttttaaaa tactctcata tagtcacact ttaaattaag     3780

ccttatatta ggcccctcta ttttcaggat ataattctta actatcatta tttacctgat     3840

tttaatcatc agattcgaaa ttctgtgcca tggcatatat gttcaaattc aaaccatttt     3900

taaaatgtga agatggactt catgcaagtt ggcagtggtt ctggtactaa aaattgtggt     3960

tgttttttct gtttacgtaa cctgcttagt attgacactc tctaccaaga gggtcttcct     4020

aagaagagtg ctgtcattat ttcctcttat caacaacttg tgacatgaga ttttttaagg     4080

gctttatgtg aactatgata ttgtaatttt tctaagcata ttcaaaaggg tgacaaaatt     4140

acgtttatgt actaaatcta atcaggaaag taaggcagga aaagttgatg gtattcatta     4200

ggttttaact gaatggagca gttccttata taataacaat tgtatagtag ggataaaaca     4260

ctaacttaat gtgtattcat tttaaattgt tctgtatttt taaattgcca agaaaaacaa     4320

ctttgtaaat ttggagatat tttccaacag cttttcgtct tcagtgtctt aatgtggaag     4380

ttaaccctta ccaaaaaagg aagttggcaa aaacagcctt ctagcacact tttttaaatg     4440

aataatggta gcctaaactt aatattttta taaagtattg taatattgtt ttgtggataa     4500

ttgaaataaa aagttctcat tgaatgcacc tattaatcgt tttagttgct attcatattc     4560

tcattcgttt tttaaaaact gatatattct gaatttattc ttccattgag aaaaaaatgt     4620

tcagttactt gtaactactg agcagaattt aatcaatcct ttattaaatt cagaacatta     4680

ttgaa                                                                 4685


<210> 6
<211> 543
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Arg Pro Glu Asn Thr Pro Glu Pro Val Ser Thr Ser Val Ser His Tyr 
            20                  25                  30          


Gly Ala Glu Pro Thr Thr Val Ser Pro Cys Pro Ser Ser Ser Ala Lys 
        35                  40                  45              


Gly Thr Ala Val Asn Phe Ser Ser Leu Ser Met Thr Pro Phe Gly Gly 
    50                  55                  60                  


Ser Ser Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val 
65                  70                  75                  80  


Val Pro Ser Ser Tyr Pro Ala Gly Leu Thr Gly Gly Val Thr Ile Phe 
                85                  90                  95      


Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe 
            100                 105                 110         


Lys Lys Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp 
        115                 120                 125             


Trp Glu Ala Arg Ser Ile Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser 
    130                 135                 140                 


Asn Tyr Val Ala Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe 
145                 150                 155                 160 


Gly Lys Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly 
                165                 170                 175     


Asn Gln Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly 
            180                 185                 190         


Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn 
        195                 200                 205             


Val Lys His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile 
    210                 215                 220                 


Thr Thr Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr 
225                 230                 235                 240 


Thr Glu His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro 
                245                 250                 255     


Thr Val Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile 
            260                 265                 270         


Pro Arg Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe 
        275                 280                 285             


Gly Glu Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile 
    290                 295                 300                 


Lys Thr Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu 
305                 310                 315                 320 


Ala Gln Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr 
                325                 330                 335     


Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser 
            340                 345                 350         


Lys Gly Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu 
        355                 360                 365             


Lys Leu Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met 
    370                 375                 380                 


Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
385                 390                 395                 400 


Asn Ile Leu Val Gly Glu Asn Leu Val Cys Lys Ile Ala Asp Phe Gly 
                405                 410                 415     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala 
            420                 425                 430         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg 
        435                 440                 445             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu 
    450                 455                 460                 


Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu 
465                 470                 475                 480 


Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly 
                485                 490                 495     


Cys Pro Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp 
            500                 505                 510         


Pro Asp Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp 
        515                 520                 525             


Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540             


<210> 7
<211> 3628
<212> DNA
<213> Homo sapiens

<400> 7
agagcatcag caagagtagc agcgagcagc cgcgctggtg gcggcggcgc gtcgttgcag       60

ttgcgccatc tgtcaggagc ggagccggcg aggagggggc tgccgcgggc gaggaggagg      120

ggtcgccgcg agccgaaggc cttcgagacc cgcccgccgc ccggcggcga gagtagaggc      180

gaggttgttg tgcgagcggc gcgtcctctc ccgcccgggc gcgccgcgct tctcccagcg      240

caccgaggac cgcccgggcg cacacaaagc cgccgcccgc gccgcaccgc ccggcggccg      300

ccgcccgcgc cagggaggga ttcggccgcc gggccgggga caccccggcg ccgccccctc      360

ggtgctctcg gaaggcccac cggctcccgg gcccgccggg gaccccccgg agccgcctcg      420

gccgcgccgg aggagggcgg ggagaggacc atgtgagtgg gctccggagc ctcagcgccg      480

cgcagttttt ttgaagaagc aggatgctga tctaaacgtg gaaaaagacc agtcctgcct      540

ctgttgtaga agacatgtgg tgtatataaa gtttgtgatc gttggcggac attttggaat      600

ttagataatg ggctgtgtgc aatgtaagga taaagaagca acaaaactga cggaggagag      660

ggacggcagc ctgaaccaga gctctgggta ccgctatggc acagacccca cccctcagca      720

ctaccccagc ttcggtgtga cctccatccc caactacaac aacttccacg cagccggggg      780

ccaaggactc accgtctttg gaggtgtgaa ctcttcgtct catacgggga ccttgcgtac      840

gagaggagga acaggagtga cactctttgt ggccctttat gactatgaag cacggacaga      900

agatgacctg agttttcaca aaggagaaaa atttcaaata ttgaacagct cggaaggaga      960

ttggtgggaa gcccgctcct tgacaactgg agagacaggt tacattccca gcaattatgt     1020

ggctccagtt gactctatcc aggcagaaga gtggtacttt ggaaaacttg gccgaaaaga     1080

tgctgagcga cagctattgt cctttggaaa cccaagaggt acctttctta tccgcgagag     1140

tgaaaccacc aaaggtgcct attcactttc tatccgtgat tgggatgata tgaaaggaga     1200

ccatgtcaaa cattataaaa ttcgcaaact tgacaatggt ggatactaca ttaccacccg     1260

ggcccagttt gaaacacttc agcagcttgt acaacattac tcagagagag ctgcaggtct     1320

ctgctgccgc ctagtagttc cctgtcacaa agggatgcca aggcttaccg atctgtctgt     1380

caaaaccaaa gatgtctggg aaatccctcg agaatccctg cagttgatca agagactggg     1440

aaatgggcag tttggggaag tatggatggg tacctggaat ggaaacacaa aagtagccat     1500

aaagactctt aaaccaggca caatgtcccc cgaatcattc cttgaggaag cgcagatcat     1560

gaagaagctg aagcacgaca agctggtcca gctctatgca gtggtgtctg aggagcccat     1620

ctacatcgtc accgagtata tgaacaaagg aagtttactg gatttcttaa aagatggaga     1680

aggaagagct ctgaaattac caaatcttgt ggacatggca gcacaggtgg ctgcaggaat     1740

ggcttacatc gagcgcatga attatatcca tagagatctg cgatcagcaa acattctagt     1800

ggggaatgga ctcatatgca agattgctga cttcggattg gcccgattga tagaagacaa     1860

tgagtacaca gcaagacaag gtgcaaagtt ccccatcaag tggacggccc ccgaggcagc     1920

cctgtacggg aggttcacaa tcaagtctga cgtgtggtct tttggaatct tactcacaga     1980

gctggtcacc aaaggaagag tgccataccc aggcatgaac aaccgggagg tgctggagca     2040

ggtggagcga ggctacagga tgccctgccc gcaggactgc cccatctctc tgcatgagct     2100

catgatccac tgctggaaaa aggaccctga agaacgcccc acttttgagt acttgcagag     2160

cttcctggaa gactacttta ccgcgacaga gccccagtac caacctggtg aaaacctgta     2220

aggcccgggt ctgcggagag aggccttgtc ccagaggctg ccccacccct ccccattagc     2280

tttcaattcc gtagccagct gctccccagc agcggaaccg cccaggatca gattgcatgt     2340

gactctgaag ctgacgaact tccatggccc tcattaatga cacttgtccc caaatccgaa     2400

cctcctctgt gaagcattcg agacagaacc ttgttatttc tcagactttg gaaaatgcat     2460

tgtatcgatg ttatgtaaaa ggccaaacct ctgttcagtg taaatagtta ctccagtgcc     2520

aacaatccta gtgctttcct tttttaaaaa tgcaaatcct atgtgatttt aactctgtct     2580

tcacctgatt caactaaaaa aaaaaaagta ttattttcca aaagtggcct ctttgtctaa     2640

aacaataaaa ttttttttca tgttttaaca aaaaccaatc aggacaggtg tttgtttttg     2700

ttttcttttt tataaatatg aatatatata atatatatgt ccctgtacat atacaatgtg     2760

ggtgctaatg tggagactgt ggccggcctg agccaccaag ctgcgggacc cagagggagg     2820

attttactgc aagtcagcat caaagcaccg gtgttattct gaaaacacca gtggcctcat     2880

ttttggcttt tgcaaagcat gaattttttc atttggattg cactttcctg gttcatgact     2940

gtacctgtag gtggttgtta ctttgactct tttcaggaac caccccccaa gctgaattta     3000

caagttctgt tagcactatt tgcttcaact tactgcgatt tgttctcaaa acttaaaaat     3060

aagcaagcaa atggctgata ctaccaagag aactggaaga tggataccac acaaacttct     3120

tgtataaaaa tatgaatgct gaaatgtttc agacattttt aatttaataa acctgtaacc     3180

acatttaagt gatctaaaac ccatagcatt gtagtcatgg caacccgcta aactttctca     3240

tgcaactaaa atttctgggg gaaatgaggg tgggggttgt acatttccca ttgtaaaata     3300

agtgttttaa atgtcctgta ctgctaacga atgactttct atatgtccag gagttctcca     3360

gtggaataac tatgcactac tttacatttc atggggatgc acaaaaacaa aaaagtatta     3420

catttttagt tgctgtttgt accaacctta aattacatat gtttaacaac aacaaatcaa     3480

aaatcctatt tctattgagt ttttaatact gactagcaac tctgaagtct taattccttt     3540

tttgttatga tttatttgtg agtttacatt tttaaattgt ttaactttct taatttagta     3600

attaaaaaga gagcatttta catttgaa                                        3628


<210> 8
<211> 537
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210> 9
<211> 2442
<212> DNA
<213> Homo sapiens

<400> 9
tacacacatg agagatcact tagagcaaag ggtgagaggg gcaggtgggg ctagggtgga       60

gaccaaagca ctgatgtgac ggaaccatca gccaggcaac tggacctggt ggatccagga      120

agactttctg gaagaggtct ctgacccctc ccaaggatca tgccgcagcc ccactgaccc      180

aggagtaggg gcctaagggc agggaacctg gaatgggctg tgtgttctgc aagaaattgg      240

agccggtggc cacggccaag gaggatgctg gcctggaagg ggacttcaga agctacgggg      300

cagcagacca ctatgggcct gaccccacta aggcccggcc tgcatcctca tttgcccaca      360

tccccaacta cagcaacttc tcctctcagg ccatcaaccc tggcttcctt gatagtggca      420

ccatcagggg tgtgtcaggg attggggtga ccctgttcat tgccctgtat gactatgagg      480

ctcgaactga ggatgacctc accttcacca agggcgagaa gttccacatc ctgaacaata      540

ctgaaggtga ctggtgggag gctcggtctc tcagctccgg aaaaactggc tgcattccca      600

gcaactacgt ggcccctgtt gactcaatcc aagctgaaga gtggtacttt ggaaagattg      660

ggagaaagga tgcagagagg cagctgcttt caccaggcaa cccccagggg gcctttctca      720

ttcgggaaag cgagaccacc aaaggtgcct actccctgtc catccgggac tgggatcaga      780

ccagaggcga tcatgtgaag cattacaaga tccgcaaact ggacatgggc ggctactaca      840

tcaccacacg ggttcagttc aactcggtgc aggagctggt gcagcactac atggaggtga      900

atgacgggct gtgcaacctg ctcatcgcgc cctgcaccat catgaagccg cagacgctgg      960

gcctggccaa ggacgcctgg gagatcagcc gcagctccat cacgctggag cgccggctgg     1020

gcaccggctg cttcggggat gtgtggctgg gcacgtggaa cggcagcact aaggtggcgg     1080

tgaagacgct gaagccgggc accatgtccc cgaaggcctt cctggaggag gcgcaggtca     1140

tgaagctgct gcggcacgac aagctggtgc agctgtacgc cgtggtgtcg gaggagccca     1200

tctacatcgt gaccgagttc atgtgtcacg gcagcttgct ggattttctc aagaacccag     1260

agggccagga tttgaggctg ccccaattgg tggacatggc agcccaggta gctgagggca     1320

tggcctacat ggaacgcatg aactacattc accgcgacct gagggcagcc aacatcctgg     1380

ttggggagcg gctggcgtgc aagatcgcag actttggctt ggcgcgtctc atcaaggacg     1440

atgagtacaa cccctgccaa ggttccaagt tccccatcaa gtggacagcc ccagaagctg     1500

ccctctttgg cagattcacc atcaagtcag acgtgtggtc ctttgggatc ctgctcactg     1560

agctcatcac caagggccga atcccctacc caggcatgaa taaacgggaa gtgttggaac     1620

aggtggagca gggctaccac atgccgtgcc ctccaggctg cccagcatcc ctgtacgagg     1680

ccatggaaca gacctggcgt ctggacccgg aggagaggcc taccttcgag tacctgcagt     1740

ccttcctgga ggactacttc acctccgctg aaccacagta ccagcccggg gatcagacat     1800

agcctgtccg ggcatcaacc ctctctggcg gtggccacca gtccttgcca atccccagag     1860

ctgttcttcc aaagccccca ggctggctta gaaccccata gagtcctagc atcaccgagg     1920

acgtggctgc tctgacacca cctagggcaa cctacttgtt ttacagatgg ggcaaaagga     1980

ggcccagagc tgatctctca tccgctctgg ccccaagcac tatttcttcc ttttccactt     2040

aggcccctac atgcctgtag cctttctcac tccatcccca cccaaagtgc tcagaccttg     2100

tctagttatt tataaaactg tatgtacctc cctcacttct ctcctatcac tgctttccta     2160

ctctcctttt atctcactct agtccaggtg ccaagaattt cccttctacc ctctattctc     2220

ttgtgtctgt aagttacaaa gtcaggaaaa gtcttggctg gacccctttc ctgctgggtg     2280

gatgcagtgg tccaggactg gggtctgggc ccaggtttga gggagaaggt tgcagagcac     2340

ttcccacctc tctgaatagt gtgtatgtgt tggtttattg attctgtaaa taagtaaaat     2400

gacaatatga atcctcaaac catgaaaaaa aaaaaaaaaa aa                        2442


<210> 10
<211> 529
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Val Ala Thr Ala Lys 
1               5                   10                  15      


Glu Asp Ala Gly Leu Glu Gly Asp Phe Arg Ser Tyr Gly Ala Ala Asp 
            20                  25                  30          


His Tyr Gly Pro Asp Pro Thr Lys Ala Arg Pro Ala Ser Ser Phe Ala 
        35                  40                  45              


His Ile Pro Asn Tyr Ser Asn Phe Ser Ser Gln Ala Ile Asn Pro Gly 
    50                  55                  60                  


Phe Leu Asp Ser Gly Thr Ile Arg Gly Val Ser Gly Ile Gly Val Thr 
65                  70                  75                  80  


Leu Phe Ile Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Glu Asp Asp Leu 
                85                  90                  95      


Thr Phe Thr Lys Gly Glu Lys Phe His Ile Leu Asn Asn Thr Glu Gly 
            100                 105                 110         


Asp Trp Trp Glu Ala Arg Ser Leu Ser Ser Gly Lys Thr Gly Cys Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln Ala Glu Glu Trp 
    130                 135                 140                 


Tyr Phe Gly Lys Ile Gly Arg Lys Asp Ala Glu Arg Gln Leu Leu Ser 
145                 150                 155                 160 


Pro Gly Asn Pro Gln Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Gln Thr Arg Gly 
            180                 185                 190         


Asp His Val Lys His Tyr Lys Ile Arg Lys Leu Asp Met Gly Gly Tyr 
        195                 200                 205             


Tyr Ile Thr Thr Arg Val Gln Phe Asn Ser Val Gln Glu Leu Val Gln 
    210                 215                 220                 


His Tyr Met Glu Val Asn Asp Gly Leu Cys Asn Leu Leu Ile Ala Pro 
225                 230                 235                 240 


Cys Thr Ile Met Lys Pro Gln Thr Leu Gly Leu Ala Lys Asp Ala Trp 
                245                 250                 255     


Glu Ile Ser Arg Ser Ser Ile Thr Leu Glu Arg Arg Leu Gly Thr Gly 
            260                 265                 270         


Cys Phe Gly Asp Val Trp Leu Gly Thr Trp Asn Gly Ser Thr Lys Val 
        275                 280                 285             


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Lys Ala Phe Leu 
    290                 295                 300                 


Glu Glu Ala Gln Val Met Lys Leu Leu Arg His Asp Lys Leu Val Gln 
305                 310                 315                 320 


Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe 
                325                 330                 335     


Met Cys His Gly Ser Leu Leu Asp Phe Leu Lys Asn Pro Glu Gly Gln 
            340                 345                 350         


Asp Leu Arg Leu Pro Gln Leu Val Asp Met Ala Ala Gln Val Ala Glu 
        355                 360                 365             


Gly Met Ala Tyr Met Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg 
    370                 375                 380                 


Ala Ala Asn Ile Leu Val Gly Glu Arg Leu Ala Cys Lys Ile Ala Asp 
385                 390                 395                 400 


Phe Gly Leu Ala Arg Leu Ile Lys Asp Asp Glu Tyr Asn Pro Cys Gln 
                405                 410                 415     


Gly Ser Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Phe 
            420                 425                 430         


Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu 
        435                 440                 445             


Thr Glu Leu Ile Thr Lys Gly Arg Ile Pro Tyr Pro Gly Met Asn Lys 
    450                 455                 460                 


Arg Glu Val Leu Glu Gln Val Glu Gln Gly Tyr His Met Pro Cys Pro 
465                 470                 475                 480 


Pro Gly Cys Pro Ala Ser Leu Tyr Glu Ala Met Glu Gln Thr Trp Arg 
                485                 490                 495     


Leu Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu 
            500                 505                 510         


Glu Asp Tyr Phe Thr Ser Ala Glu Pro Gln Tyr Gln Pro Gly Asp Gln 
        515                 520                 525             


Thr 
    


<210> 11
<211> 2118
<212> DNA
<213> Homo sapiens

<400> 11
gtgtgaattt acttgtagcc tgagggctca gagggagcac cggtttggag ctgggacccc       60

ctattttagc ttttctgtgg ctggtgaatg gggatcccag gatctcacaa tctcagggac      120

catgggctgt ggctgcagct cacacccgga agatgactgg atggaaaaca tcgatgtgtg      180

tgagaactgc cattatccca tagtcccact ggatggcaag ggcacgctgc tcatccgaaa      240

tggctctgag gtgcgggacc cactggttac ctacgaaggc tccaatccgc cggcttcccc      300

actgcaagac aacctggtta tcgctctgca cagctatgag ccctctcacg acggagatct      360

gggctttgag aagggggaac agctccgcat cctggagcag agcggcgagt ggtggaaggc      420

gcagtccctg accacgggcc aggaaggctt catccccttc aattttgtgg ccaaagcgaa      480

cagcctggag cccgaaccct ggttcttcaa gaacctgagc cgcaaggacg cggagcggca      540

gctcctggcg cccgggaaca ctcacggctc cttcctcatc cgggagagcg agagcaccgc      600

gggatcgttt tcactgtcgg tccgggactt cgaccagaac cagggagagg tggtgaaaca      660

ttacaagatc cgtaatctgg acaacggtgg cttctacatc tcccctcgaa tcacttttcc      720

cggcctgcat gaactggtcc gccattacac caatgcttca gatgggctgt gcacacggtt      780

gagccgcccc tgccagaccc agaagcccca gaagccgtgg tgggaggacg agtgggaggt      840

tcccagggag acgctgaagc tggtggagcg gctgggggct ggacagttcg gggaggtgtg      900

gatggggtac tacaacgggc acacgaaggt ggcggtgaag agcctgaagc agggcagcat      960

gtccccggac gccttcctgg ccgaggccaa cctcatgaag cagctgcaac accagcggct     1020

ggttcggctc tacgctgtgg tcacccagga gcccatctac atcatcactg aatacatgga     1080

gaatgggagt ctagtggatt ttctcaagac cccttcaggc atcaagttga ccatcaacaa     1140

actcctggac atggcagccc aaattgcaga aggcatggca ttcattgaag agcggaatta     1200

tattcatcgt gaccttcggg ctgccaacat tctggtgtct gacaccctga gctgcaagat     1260

tgcagacttt ggcctagcac gcctcattga ggacaacgag tacacagcca gggagggggc     1320

caagtttccc attaagtgga cagcgccaga agccattaac tacgggacat tcaccatcaa     1380

gtcagatgtg tggtcttttg ggatcctgct gacggaaatt gtcacccacg gccgcatccc     1440

ttacccaggg atgaccaacc cggaggtgat tcagaacctg gagcgaggct accgcatggt     1500

gcgccctgac aactgtccag aggagctgta ccaactcatg aggctgtgct ggaaggagcg     1560

cccagaggac cggcccacct ttgactacct gcgcagtgtg ctggaggact tcttcacggc     1620

cacagagggc cagtaccagc ctcagccttg agaggccttg agaggccctg gggttctccc     1680

cctttctctc cagcctgact tggggagatg gagttcttgt gccatagtca catggcctat     1740

gcacatatgg actctgcaca tgaatcccac ccacatgtga cacatatgca ccttgtgtct     1800

gtacacgtgt cctgtagttg cgtggactct gcacatgtct tgtacatgtg tagcctgtgc     1860

atgtatgtct tggacactgt acaaggtacc cctttctggc tctcccattt cctgagacca     1920

cagagagagg ggagaagcct gggattgaca gaagcttctg cccacctact tttctttcct     1980

cagatcatcc agaagttcct caagggccag gactttatct aatacctctg tgtgctcctc     2040

cttggtgcct ggcctggcac acatcaggag ttcaataaat gtctgttgat gactgttgta     2100

aaaaaaaaaa aaaaaaaa                                                   2118


<210> 12
<211> 509
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210> 13
<211> 2168
<212> DNA
<213> Homo sapiens

<400> 13
ggagttagcc tcgctcaggg cgcggctaag gcgcccagat ggcctgcggg cgccaccacg       60

tccctggtcc cagctcggga gcacatcaga ggcttagagg cgagtgggaa gggactcaga      120

cagtgcagga cgagaaacgc ccgcggcacc aaagcccctc agagcgtcgc ccccgcctct      180

agttctagaa agtcagtttc ccggcactgg caccccggaa cctcaggggc tgccgagctg      240

ggggggcgct caagctgcga ggatccgggc tgcccgcgag acgaggagcg ggcgcccagg      300

atggggtgca tgaagtccaa gttcctccag gtcggaggca atacattctc aaaaactgaa      360

accagcgcca gcccacactg tcctgtgtac gtgccggatc ccacatccac catcaagccg      420

gggcctaata gccacaacag caacacacca ggaatcaggg aggcaggctc tgaggacatc      480

atcgtggttg ccctgtatga ttacgaggcc attcaccacg aagacctcag cttccagaag      540

ggggaccaga tggtggtcct agaggaatcc ggggagtggt ggaaggctcg atccctggcc      600

acccggaagg agggctacat cccaagcaac tatgtcgccc gcgttgactc tctggagaca      660

gaggagtggt ttttcaaggg catcagccgg aaggacgcag agcgccaact gctggctccc      720

ggcaacatgc tgggctcctt catgatccgg gatagcgaga ccactaaagg aagctactct      780

ttgtccgtgc gagactacga ccctcggcag ggagataccg tgaaacatta caagatccgg      840

accctggaca acgggggctt ctacatatcc ccccgaagca ccttcagcac tctgcaggag      900

ctggtggacc actacaagaa ggggaacgac gggctctgcc agaaactgtc ggtgccctgc      960

atgtcttcca agccccagaa gccttgggag aaagatgcct gggagatccc tcgggaatcc     1020

ctcaagctgg agaagaaact tggagctggg cagtttgggg aagtctggat ggccacctac     1080

aacaagcaca ccaaggtggc agtgaagacg atgaagccag ggagcatgtc ggtggaggcc     1140

ttcctggcag aggccaacgt gatgaaaact ctgcagcatg acaagctggt caaacttcat     1200

gcggtggtca ccaaggagcc catctacatc atcacggagt tcatggccaa aggaagcttg     1260

ctggactttc tgaaaagtga tgagggcagc aagcagccat tgccaaaact cattgacttc     1320

tcagcccaga ttgcagaagg catggccttc atcgagcaga ggaactacat ccaccgagac     1380

ctccgagctg ccaacatctt ggtctctgca tccctggtgt gtaagattgc tgactttggc     1440

ctggcccggg tcattgagga caacgagtac acggctcggg aaggggccaa gttccccatc     1500

aagtggacag ctcctgaagc catcaacttt ggctccttca ccatcaagtc agacgtctgg     1560

tcctttggta tcctgctgat ggagatcgtc acctacggcc ggatccctta cccagggatg     1620

tcaaaccctg aagtgatccg agctctggag cgtggatacc ggatgcctcg cccagagaac     1680

tgcccagagg agctctacaa catcatgatg cgctgctgga aaaaccgtcc ggaggagcgg     1740

ccgaccttcg aatacatcca gagtgtgctg gatgacttct acacggccac agagagccag     1800

taccaacagc agccatgata gggaggacca gggcagggcc agggggtgcc caggtggtgg     1860

ctgcaaggtg gctccagcac catccgccag ggcccacacc cccttcctac tcccagacac     1920

ccaccctcgc ttcagccaca gtttcctcat ctgtccagtg ggtaggttgg actggaaaat     1980

ctctttttga ctcttgcaat ccacaatctg acattctcag gaagccccca agttgatatt     2040

tctatttcct ggaatggttg gattttagtt acagctgtga tttggaaggg aaactttcaa     2100

aatagtgaaa tgaatattta aataaaagat ataaatgcca aagtctttac caaaaaaaaa     2160

aaaaaaaa                                                              2168


<210> 14
<211> 505
<212> PRT
<213> Homo sapiens

<400> 14
Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val Gly Gly Asn Thr Phe 
1               5                   10                  15      


Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys Pro Val Tyr Val Pro 
            20                  25                  30          


Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn Ser His Asn Ser Asn 
        35                  40                  45              


Thr Pro Gly Ile Arg Glu Ala Gly Ser Glu Asp Ile Ile Val Val Ala 
    50                  55                  60                  


Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp Leu Ser Phe Gln Lys 
65                  70                  75                  80  


Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly Glu Trp Trp Lys Ala 
                85                  90                  95      


Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile Pro Ser Asn Tyr Val 
            100                 105                 110         


Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp Phe Phe Lys Gly Ile 
        115                 120                 125             


Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Met Leu 
    130                 135                 140                 


Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr Lys Gly Ser Tyr Ser 
145                 150                 155                 160 


Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly Asp Thr Val Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp His Tyr Lys Lys Gly 
        195                 200                 205             


Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro Cys Met Ser Ser Lys 
    210                 215                 220                 


Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser 
225                 230                 235                 240 


Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala Val Lys Thr Met Lys 
            260                 265                 270         


Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala Glu Ala Asn Val Met 
        275                 280                 285             


Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu His Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met Ala Lys Gly Ser Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys Gln Pro Leu Pro Lys 
                325                 330                 335     


Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Phe Ile Glu 
            340                 345                 350         


Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Val 
    370                 375                 380                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile 
385                 390                 395                 400 


Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser Phe Thr Ile Lys 
                405                 410                 415     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met Glu Ile Val Thr Tyr 
            420                 425                 430         


Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Ala 
        435                 440                 445             


Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu Asn Cys Pro Glu Glu 
    450                 455                 460                 


Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
            500                 505 


<210> 15
<211> 2642
<212> DNA
<213> Homo sapiens

<400> 15
cacacagatg gcacatggca gagcccaagc cctctccatg agatctgcag cgtttgtcca       60

cacggcaggg caaattacct tgtagagtca gcatggaggt ttgctaactc tgccggactt      120

ggtgcagaaa aaataccagc cgtgctgtta aaccaaaacc ccaggagaaa actttctggt      180

gacagaaggg cattgtgacc cacgttgccc agggccaggg acagggcagc tgctcatggt      240

ccttcctcac gagttttcct ggagcagagg gataccccca aacccaggga gcccacagga      300

gcttcagaag ggctcggctg gagggcgggg cccctgttgc acttgctcac tggggactgg      360

ggaggctctg atcgcagacc gggggtgctg ccacctctgt ctgctgccgg cagaaagcca      420

caagccatga aaactgattg agatgagaag aattcatctg ggactggctt ttgctttagg      480

atggtgttgg aagttgctcg ttgtcgctag gagcctgctc cactgtaagg gtgtcaggat      540

ctgaagagct atggtgaaac accactgaag cattgccaag gatggggctg gtaagtagca      600

aaaagccgga caaggaaaag ccgatcaaag agaaggacaa gggccaatgg agccccctga      660

aggtcagcgc ccaagacaag gacgccccgc cactgccgcc cctggttgtc ttcaaccacc      720

ttactcctcc accgcccgat gaacacctgg atgaagacaa gcatttcgtg gtggctctgt      780

atgactacac cgctatgaat gatcgggacc tgcagatgct gaagggggag aagctacagg      840

tcctgaaggg aactggagac tggtggctgg ccaggtcact cgtcacagga agagaaggct      900

atgtgcccag taactttgtg gcccgagtgg agagcctgga aatggaaagg tggttcttta      960

gatcacaggg tcggaaggag gctgagaggc agcttcttgc tccaatcaac aaggccggct     1020

cctttcttat cagagagagt gaaaccaaca aaggtgcctt ctccctgtct gtgaaggatg     1080

tcaccaccca gggggagctg atcaagcact ataagatccg ctgcctggat gaagggggct     1140

actacatctc cccccggatc accttcccct cgctccaggc cctggtgcag cactattcta     1200

agaaggggga tggtctatgc cagaggctga ccctgccctg tgtgcgcccg gccccgcaga     1260

atccctgggc ccaggatgaa tgggagatcc cccggcagtc tctcaggctg gtcaggaaac     1320

tcgggtctgg acaattcggc gaagtctgga tgggttacta caaaaacaac atgaaggtgg     1380

ccattaagac gctgaaggag ggaaccatgt ctccagaagc ctttctgggt gaggccaacg     1440

tgatgaaggc tctgcagcac gagcggctgg tccgactcta cgcagtggtc accaaggagc     1500

ccatctacat tgtcaccgag tacatggcca gaggatgcct gctggatttc ctgaagacag     1560

atgaagggag cagattgtca ctcccaaggc tgattgacat gtcggcgcag attgctgaag     1620

ggatggcata cattgagcgc atgaattcca tccaccgcga cctgcgggcg gccaacatcc     1680

tggtgtctga ggccttgtgc tgcaaaattg ctgattttgg cttggctcga atcatcgaca     1740

gtgaatacac ggcccaagag ggggccaagt tccccatcaa gtggacagcc ccggaagcca     1800

tccacttcgg ggtcttcacc atcaaagcag acgtgtggtc gtttggagtc ctcctgatgg     1860

aagttgtcac ttatgggcgg gtgccatacc cagggatgag caaccccgag gtcatccgca     1920

acctggagcg cggctaccgc atgccgcgcc ccgacacctg cccgcccgag ctgtaccgcg     1980

gcgtcatcgc cgagtgctgg cgcagccggc ccgaggagcg gcccaccttc gagttcctgc     2040

agtcggtgct ggaggacttc tacacggcca ccgagcggca gtacgagctg cagccctagc     2100

cggccgcgcc cgcctgcgcc ccgtgcccac ctctgcgcgg acgaccccga cttccgtgcc     2160

atcccagacg ggccgcgaag gcggggtgtc gcctgtgccc ttttctcaga cccggaatcc     2220

agtgggcaga ggcagcttcg cagggggtcc ccggacggac tccttcaccg actgcacccc     2280

cgggcgagtt acgcggcctc tctgtgccgc ttcatttgta gagggctgta acagtgacct     2340

cgcacggtca tccggagtac taagccccag taaggtgttc aggactggta agcgactgtc     2400

atcaagtaag gcccccgtgc tgggcacccc ccgtgctggc cgcgtccccg cctctgcgcc     2460

ctgcgtggac cccgccctgc cccgctacag aagccagact gggtcccgcg gacgccagca     2520

ggggcagccc cagcctaggc tgcgctccag cactgcgggg cttttctgca ataaagtcac     2580

gagcgttcga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2640

aa                                                                    2642


<210> 16
<211> 505
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Leu Val Ser Ser Lys Lys Pro Asp Lys Glu Lys Pro Ile Lys 
1               5                   10                  15      


Glu Lys Asp Lys Gly Gln Trp Ser Pro Leu Lys Val Ser Ala Gln Asp 
            20                  25                  30          


Lys Asp Ala Pro Pro Leu Pro Pro Leu Val Val Phe Asn His Leu Thr 
        35                  40                  45              


Pro Pro Pro Pro Asp Glu His Leu Asp Glu Asp Lys His Phe Val Val 
    50                  55                  60                  


Ala Leu Tyr Asp Tyr Thr Ala Met Asn Asp Arg Asp Leu Gln Met Leu 
65                  70                  75                  80  


Lys Gly Glu Lys Leu Gln Val Leu Lys Gly Thr Gly Asp Trp Trp Leu 
                85                  90                  95      


Ala Arg Ser Leu Val Thr Gly Arg Glu Gly Tyr Val Pro Ser Asn Phe 
            100                 105                 110         


Val Ala Arg Val Glu Ser Leu Glu Met Glu Arg Trp Phe Phe Arg Ser 
        115                 120                 125             


Gln Gly Arg Lys Glu Ala Glu Arg Gln Leu Leu Ala Pro Ile Asn Lys 
    130                 135                 140                 


Ala Gly Ser Phe Leu Ile Arg Glu Ser Glu Thr Asn Lys Gly Ala Phe 
145                 150                 155                 160 


Ser Leu Ser Val Lys Asp Val Thr Thr Gln Gly Glu Leu Ile Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Cys Leu Asp Glu Gly Gly Tyr Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ile Thr Phe Pro Ser Leu Gln Ala Leu Val Gln His Tyr Ser Lys Lys 
        195                 200                 205             


Gly Asp Gly Leu Cys Gln Arg Leu Thr Leu Pro Cys Val Arg Pro Ala 
    210                 215                 220                 


Pro Gln Asn Pro Trp Ala Gln Asp Glu Trp Glu Ile Pro Arg Gln Ser 
225                 230                 235                 240 


Leu Arg Leu Val Arg Lys Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Gly Tyr Tyr Lys Asn Asn Met Lys Val Ala Ile Lys Thr Leu Lys 
            260                 265                 270         


Glu Gly Thr Met Ser Pro Glu Ala Phe Leu Gly Glu Ala Asn Val Met 
        275                 280                 285             


Lys Ala Leu Gln His Glu Arg Leu Val Arg Leu Tyr Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Ala Arg Gly Cys Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Thr Asp Glu Gly Ser Arg Leu Ser Leu Pro Arg 
                325                 330                 335     


Leu Ile Asp Met Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile Glu 
            340                 345                 350         


Arg Met Asn Ser Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Glu Ala Leu Cys Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile 
    370                 375                 380                 


Ile Asp Ser Glu Tyr Thr Ala Gln Glu Gly Ala Lys Phe Pro Ile Lys 
385                 390                 395                 400 


Trp Thr Ala Pro Glu Ala Ile His Phe Gly Val Phe Thr Ile Lys Ala 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Val Leu Leu Met Glu Val Val Thr Tyr Gly 
            420                 425                 430         


Arg Val Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Asn Leu 
        435                 440                 445             


Glu Arg Gly Tyr Arg Met Pro Arg Pro Asp Thr Cys Pro Pro Glu Leu 
    450                 455                 460                 


Tyr Arg Gly Val Ile Ala Glu Cys Trp Arg Ser Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Phe Leu Gln Ser Val Leu Glu Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Arg Gln Tyr Glu Leu Gln Pro 
            500                 505 


<210> 17
<211> 4095
<212> DNA
<213> Homo sapiens

<400> 17
agacagccag ttcctctccc gccgcgccgg gccgcgctgc cgctcgctcc ccggccgtgg       60

cgcctccggg ccagacgcgc tgcagcctcc agcccgcggc aagcggggcg gccgcgccac      120

ccccggcccc gcgccagcag cccctcgccg cgcgtccagc gttcccggcc agcagcctcc      180

ccatacgcag gtcctgctgg gccgccccgt cgcgcccccc actctgaact caagtcaccg      240

tggagctccg ccgccccgaa actttcaccg cgagcgggaa atatgggatg tataaaatca      300

aaagggaaag acagcttgag tgacgatgga gtagatttga agactcaacc agttccagaa      360

tctcagcttt tacctggaca gaggtttcaa actaaagatc cagaggaaca aggagacatt      420

gtggtagcct tgtaccccta tgatggcatc cacccggacg acttgtcttt caagaaagga      480

gagaagatga aagtcctgga ggagcatgga gaatggtgga aagcaaagtc ccttttaaca      540

aaaaaagaag gcttcatccc cagcaactat gtggccaaac tcaacacctt agaaacagaa      600

gagtggtttt tcaaggatat aaccaggaag gacgcagaaa ggcagctttt ggcaccagga      660

aatagcgctg gagctttcct tattagagaa agtgaaacat taaaaggaag cttctctctg      720

tctgtcagag actttgaccc tgtgcatggt gatgttatta agcactacaa aattagaagt      780

ctggataatg ggggctatta catctctcca cgaatcactt ttccctgtat cagcgacatg      840

attaaacatt accaaaagca ggcagatggc ttgtgcagaa gattggagaa ggcttgtatt      900

agtcccaagc cacagaagcc atgggataaa gatgcctggg agatcccccg ggagtccatc      960

aagttggtga aaaggcttgg cgctgggcag tttggggaag tctggatggg ttactataac     1020

aacagtacca aggtggctgt gaaaaccctg aagccaggaa ctatgtctgt gcaagccttc     1080

ctggaagaag ccaacctcat gaagaccctg cagcatgaca agctcgtgag gctctacgct     1140

gtggtcacca gggaggagcc catttacatc atcaccgagt acatggccaa gggcagtttg     1200

ctggatttcc tgaagagcga tgaaggtggc aaagtgctgc ttccaaagct cattgacttt     1260

tctgctcaga ttgcagaggg aatggcatac atcgagcgga agaactacat tcaccgggac     1320

ctgcgagcag ctaatgttct ggtctccgag tcactcatgt gcaaaattgc agattttggc     1380

cttgctagag taattgaaga taatgagtac acagcaaggg aaggtgctaa gttccctatt     1440

aagtggacgg ctccagaagc aatcaacttt ggatgtttca ctattaagtc tgatgtgtgg     1500

tcctttggaa tcctcctata cgaaattgtc acctatggga aaattcccta cccagggaga     1560

actaatgccg acgtgatgac cgccctgtcc cagggctaca ggatgccccg tgtggagaac     1620

tgcccagatg agctctatga cattatgaaa atgtgctgga aagaaaaggc agaagagaga     1680

ccaacgtttg actacttaca gagcgtcctg gatgatttct acacagccac ggaagggcaa     1740

taccagcagc agccttagag cacagggaga cccgtccatt tggcaggggt ggctgcctca     1800

tttagagagg aaaagtaacc atcactggtt gcacttatga tttcatgtgc ggggatcatc     1860

tgccgtgcct ggatcctgaa atagaggcta aattactcag gaagaacacc ctctaaatgg     1920

gaaagtattc tgtactctta gatggattct ccactcagtt gcaacttgga cttgtcctca     1980

gcagctggta atcttgctct gcttgacaac atctgagtgc agccgtttga gaagaaaaca     2040

tctattctct ccaaaaatgc acccaactag ctctatgttt acaaatggac ataggactca     2100

aagtttcaga gaccattgca atgaatcccc aataattgca gaactaaact catttataaa     2160

gctaaaataa ccggatatat acatagcatg acatttcttt gtgctttggc ttacttgttt     2220

aaaaaaaaaa aaaaactaat ccaacctgtt agattttgca ggtgaagtca gcagcttaaa     2280

aatgtctttc ccagatttca atgatttttt tccccctacc tcccaaaatc tgagactgtt     2340

aaaacatttt tcttctatga acactgctca gacctgctag acatgccata ggagtggcgt     2400

gcacatctct ctctcttcca gcaggaggag cccgtgagca cgcacagctg ccctgtctgc     2460

tcacccgaag gcaccgggct cacctggacc tcccaggaaa gggagaagag cctcagaaac     2520

tgctctgtgt ttagaaggaa tatttttaag agtccagctt tttcatttcc acaatttcct     2580

atatccagat ttgttttgac aatgtagttt ggaagaacta agattctaat ctctgaagaa     2640

ccttataggg ccttctaaaa cataagagtt tcctttgttg cttcaaatat ttgaacatta     2700

tgttaaagat caagtattaa ttttagttgt actctagaaa gctaaagtgc cacattcggg     2760

gctattttta tgattcagca atcttttcta aattgtgtag catgtgtatg agactattta     2820

tacccaagga tatgaaggaa cataagtgac tacaaggctc taataagcca cggtggcagg     2880

aggttcaagc ggttctgttc actaaatttt tctcctgtaa gctttgaatg gaaacttctg     2940

tatcacatga tgtgtttcac ttatgctgtt gtgtatatac ctaatatttc tatttttgat     3000

tttattttaa tacacctcgt ccaataacat ctcaagcttt ttatttgcat ttacattttc     3060

agctgtggtc agtgtaaaaa ttggtcatca gctgggggcg gggtggttag aagtgattca     3120

acagagctac atgctttaaa cttgcccaag ttctacctcc ttcctttgaa catttcagat     3180

tggagaacca aggagttgat tgcctgaaca cctgaacatc cgtttatggg ggccagatag     3240

aatttgtttt caaataggct taacaggcat cattaaaatt tcattctgtg tgttttgttt     3300

aggcttgagg tgcttagaag atgggataaa atattctact tttttctaaa ttttaacttt     3360

gtttcctatg tgattttttt aaatgtcctt tctaaaatat tctaaaatta ttgattcaca     3420

agtgccatgt tcagaactat agaatattac tgttacataa tgtctgcaca gctggtccct     3480

tgattcagtg gtaaggtttt tgtgtacacc cccctgcttg cattttattt cagaaccaca     3540

agtattaccc aatatgttac atggagagga actataaaga atccctaagg caaaaagaag     3600

tctctagaaa atgactagag gttttttttt tagcataaca aatttattta aagaaaatta     3660

ttaaatttat cttcgccttg ttttgcttct cccagttcct cctcttcttg ccattttcca     3720

cttgtctttc cctcccaatc aagcctgtga tccttacctc catgtgggcc cttcaccagc     3780

ttgggcctca tctctggtgt ccagcatgtg tggaagtcac acgttccctt gatgaacagc     3840

acacacagtc tccttactta gctataggtt tccagcctcc ctgtgacaga caggcataat     3900

gaggggctga ataggtgttt gtagcatttt cgggtatcca gtggtgtgca aaatggctca     3960

tgtcatcaca cctcaggtta ttgtagagaa ctggaaagac agaatccata ctccctaccg     4020

ccaagattct gacttagctg ttgtgcagcg ggagatgtat gtcagtctat tttaaaagct     4080

tctccagtca gctag                                                      4095


<210> 18
<211> 491
<212> PRT
<213> Homo sapiens

<400> 18
Met Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Leu Ser Asp Asp Gly 
1               5                   10                  15      


Val Asp Leu Lys Thr Gln Pro Val Pro Glu Ser Gln Leu Leu Pro Gly 
            20                  25                  30          


Gln Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln Gly Asp Ile Val Val 
        35                  40                  45              


Ala Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp Asp Leu Ser Phe Lys 
    50                  55                  60                  


Lys Gly Glu Lys Met Lys Val Leu Glu Glu His Gly Glu Trp Trp Lys 
65                  70                  75                  80  


Ala Lys Ser Leu Leu Thr Lys Lys Glu Gly Phe Ile Pro Ser Asn Tyr 
                85                  90                  95      


Val Ala Lys Leu Asn Thr Leu Glu Thr Glu Glu Trp Phe Phe Lys Asp 
            100                 105                 110         


Ile Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Ser 
        115                 120                 125             


Ala Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Leu Lys Gly Ser Phe 
    130                 135                 140                 


Ser Leu Ser Val Arg Asp Phe Asp Pro Val His Gly Asp Val Ile Lys 
145                 150                 155                 160 


His Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly Tyr Tyr Ile Ser Pro 
                165                 170                 175     


Arg Ile Thr Phe Pro Cys Ile Ser Asp Met Ile Lys His Tyr Gln Lys 
            180                 185                 190         


Gln Ala Asp Gly Leu Cys Arg Arg Leu Glu Lys Ala Cys Ile Ser Pro 
        195                 200                 205             


Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp Glu Ile Pro Arg Glu 
    210                 215                 220                 


Ser Ile Lys Leu Val Lys Arg Leu Gly Ala Gly Gln Phe Gly Glu Val 
225                 230                 235                 240 


Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val Ala Val Lys Thr Leu 
                245                 250                 255     


Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu Glu Glu Ala Asn Leu 
            260                 265                 270         


Met Lys Thr Leu Gln His Asp Lys Leu Val Arg Leu Tyr Ala Val Val 
        275                 280                 285             


Thr Arg Glu Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Ala Lys Gly 
    290                 295                 300                 


Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Gly Lys Val Leu Leu 
305                 310                 315                 320 


Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr 
                325                 330                 335     


Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Val 
            340                 345                 350         


Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala Asp Phe Gly Leu Ala 
        355                 360                 365             


Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe 
    370                 375                 380                 


Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Cys Phe Thr 
385                 390                 395                 400 


Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Val 
                405                 410                 415     


Thr Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr Asn Ala Asp Val Met 
            420                 425                 430         


Thr Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg Val Glu Asn Cys Pro 
        435                 440                 445             


Asp Glu Leu Tyr Asp Ile Met Lys Met Cys Trp Lys Glu Lys Ala Glu 
    450                 455                 460                 


Glu Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val Leu Asp Asp Phe Tyr 
465                 470                 475                 480 


Thr Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
                485                 490     


<210> 19
<211> 2864
<212> DNA
<213> Homo sapiens

<400> 19
cctggcgaaa gcaagacgtg gaggttttac caggggttag tagcttcctc ttgctaactt       60

tttattggga caaaaggcaa gatggcacca ttctgttctc agatatttgt ctaaataaag      120

cccttttaat tttattttat ttttgttgtg ggattcttaa gcagataaga agaaaagaca      180

ccttcctagt gagcagctgc ccagctcctg ctcagttttg cctcggggta gcacctccag      240

ccacagaaag caagccggta agtctctcca ggtaggactt gctgcaaccc agctgctgga      300

ctgatctgaa acgggacttt gcatactctc cgaagtatgg tgagttggtg ctgacttcaa      360

agttgcctgg tgaaggaaga taaggtggat cgcagagact aaggggagag ggagaagccc      420

tgctcctctt ctccccacca aggcacaatg agcaacatct gtcagaggct ctgggagtac      480

ctagaaccct atctcccctg tttgtccacg gaggcagaca agtcaaccgt gattgaaaat      540

ccaggggccc tttgctctcc ccagtcacag aggcatggcc actactttgt ggctttgttt      600

gattaccagg ctcggactgc tgaggacttg agcttccgag caggtgacaa acttcaagtt      660

ctggacactt tgcatgaggg ctggtggttt gccagacact tggagaaaag acgagatggc      720

tccagtcagc aactacaagg ctatattcct tctaactacg tggctgagga cagaagccta      780

caggcagagc cgtggttctt tggagcaatc ggaagatcag atgcagagaa acaactatta      840

tattcagaaa acaagaccgg ttcctttcta atcagagaaa gtgaaagcca aaaaggagaa      900

ttctctcttt cagttttaga tggagcagtt gtaaaacact acagaattaa aagactggat      960

gaagggggat tttttctcac gcgaagaaga atcttttcaa cactgaacga atttgtgagc     1020

cactacacca agacaagtga cggcctgtgt gtcaagctgg ggaaaccatg cttaaagatc     1080

caggtcccag ctccatttga tttgtcgtat aaaaccgtgg accaatggga gatagaccgc     1140

aactccatac agcttctgaa gcgattggga tctggtcagt ttggcgaagt atgggaaggt     1200

ctgtggaaca ataccactcc agtagcagtg aaaacattaa aaccaggttc aatggatcca     1260

aatgacttcc tgagggaggc acagataatg aagaacctaa gacatccaaa gcttatccag     1320

ctttatgctg tttgcacttt agaagatcca atttatatta ttacagagtt gatgagacat     1380

ggaagtctgc aagaatatct ccaaaatgac actggatcaa aaatccatct gactcaacag     1440

gtagacatgg cggcacaggt tgcctctgga atggcctatc tggagtctcg gaactacatt     1500

cacagagatc tggctgccag aaatgtcctc gttggtgaac ataatatcta caaagtagca     1560

gattttggac ttgccagagt ttttaaggta gataatgaag acatctatga atctagacac     1620

gaaataaagc tgccggtgaa gtggactgcg cccgaagcca ttcgtagtaa taaattcagc     1680

attaagtccg atgtatggtc atttggaatc cttctttatg aaatcattac ttatggcaaa     1740

atgccttaca gtggtatgac aggtgcccag gtaatccaga tgttggctca aaactataga     1800

cttccgcaac catccaactg tccacagcaa ttttacaaca tcatgttgga gtgctggaat     1860

gcagagccta aggaacgacc tacatttgag acactgcgtt ggaaacttga agactatttt     1920

gaaacagact cttcatattc agatgcaaat aacttcataa gatgaacact ggagaagaat     1980

atcaaataat aaagtagcaa aacaaattca aataatccat tccaaaatac aatgttatca     2040

accaactgca caatcagttt atcctgacat attcaagtga taggataaag ttggccatgt     2100

attatgaaaa agattatttg tgcattttat tgactgggca acactgcagg acagtcaagg     2160

tgatatataa tttcctcact gcctggtaaa attaagcaca ctaaaccaag ttatttttct     2220

ttttaagaga tacttacatt tccatttatt gtttgaaatg tcgatcaaga gaatcaacag     2280

atgatagtcc aatttttact cagtgactgt tgtagcattt tcctgtttac tgattagagt     2340

ggttattcat tattcctcag attgctgaat cccatcaggc tgttattatg aaggaatttg     2400

attgctttgc tgcacagcag gacctgtgct ttgagatttt tttttctctt ttaaaatatc     2460

ctgtaactac aatgatggta aagccatgtt aaatgacttg attgtacttg gagtaattgc     2520

acattttttt ctatgcataa aaaaatgatg cagctgttga gaaaacgaag tctttttcat     2580

tttgcagaag gaaatgatgg aatttttctg tacttcagta tgtgtcaact gagagtcata     2640

tacattagtt ttaatctctt aatattgaga atcaggttgc aaaacggatg agttattatc     2700

tatggaaatg tgagaaatgt ctaatagccc ataaagtctg agaaataggt atcaaaatag     2760

tttaggaaaa tgagaggaga acagtaggat tgctgtggcc tagacttctg agtaattaat     2820

aaagaaaaag aagtaccctt tggcctacaa aaaaaaaaaa aaaa                      2864


<210> 20
<211> 505
<212> PRT
<213> Homo sapiens

<400> 20
Met Ser Asn Ile Cys Gln Arg Leu Trp Glu Tyr Leu Glu Pro Tyr Leu 
1               5                   10                  15      


Pro Cys Leu Ser Thr Glu Ala Asp Lys Ser Thr Val Ile Glu Asn Pro 
            20                  25                  30          


Gly Ala Leu Cys Ser Pro Gln Ser Gln Arg His Gly His Tyr Phe Val 
        35                  40                  45              


Ala Leu Phe Asp Tyr Gln Ala Arg Thr Ala Glu Asp Leu Ser Phe Arg 
    50                  55                  60                  


Ala Gly Asp Lys Leu Gln Val Leu Asp Thr Leu His Glu Gly Trp Trp 
65                  70                  75                  80  


Phe Ala Arg His Leu Glu Lys Arg Arg Asp Gly Ser Ser Gln Gln Leu 
                85                  90                  95      


Gln Gly Tyr Ile Pro Ser Asn Tyr Val Ala Glu Asp Arg Ser Leu Gln 
            100                 105                 110         


Ala Glu Pro Trp Phe Phe Gly Ala Ile Gly Arg Ser Asp Ala Glu Lys 
        115                 120                 125             


Gln Leu Leu Tyr Ser Glu Asn Lys Thr Gly Ser Phe Leu Ile Arg Glu 
    130                 135                 140                 


Ser Glu Ser Gln Lys Gly Glu Phe Ser Leu Ser Val Leu Asp Gly Ala 
145                 150                 155                 160 


Val Val Lys His Tyr Arg Ile Lys Arg Leu Asp Glu Gly Gly Phe Phe 
                165                 170                 175     


Leu Thr Arg Arg Arg Ile Phe Ser Thr Leu Asn Glu Phe Val Ser His 
            180                 185                 190         


Tyr Thr Lys Thr Ser Asp Gly Leu Cys Val Lys Leu Gly Lys Pro Cys 
        195                 200                 205             


Leu Lys Ile Gln Val Pro Ala Pro Phe Asp Leu Ser Tyr Lys Thr Val 
    210                 215                 220                 


Asp Gln Trp Glu Ile Asp Arg Asn Ser Ile Gln Leu Leu Lys Arg Leu 
225                 230                 235                 240 


Gly Ser Gly Gln Phe Gly Glu Val Trp Glu Gly Leu Trp Asn Asn Thr 
                245                 250                 255     


Thr Pro Val Ala Val Lys Thr Leu Lys Pro Gly Ser Met Asp Pro Asn 
            260                 265                 270         


Asp Phe Leu Arg Glu Ala Gln Ile Met Lys Asn Leu Arg His Pro Lys 
        275                 280                 285             


Leu Ile Gln Leu Tyr Ala Val Cys Thr Leu Glu Asp Pro Ile Tyr Ile 
    290                 295                 300                 


Ile Thr Glu Leu Met Arg His Gly Ser Leu Gln Glu Tyr Leu Gln Asn 
305                 310                 315                 320 


Asp Thr Gly Ser Lys Ile His Leu Thr Gln Gln Val Asp Met Ala Ala 
                325                 330                 335     


Gln Val Ala Ser Gly Met Ala Tyr Leu Glu Ser Arg Asn Tyr Ile His 
            340                 345                 350         


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu His Asn Ile Tyr 
        355                 360                 365             


Lys Val Ala Asp Phe Gly Leu Ala Arg Val Phe Lys Val Asp Asn Glu 
    370                 375                 380                 


Asp Ile Tyr Glu Ser Arg His Glu Ile Lys Leu Pro Val Lys Trp Thr 
385                 390                 395                 400 


Ala Pro Glu Ala Ile Arg Ser Asn Lys Phe Ser Ile Lys Ser Asp Val 
                405                 410                 415     


Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Ile Thr Tyr Gly Lys Met 
            420                 425                 430         


Pro Tyr Ser Gly Met Thr Gly Ala Gln Val Ile Gln Met Leu Ala Gln 
        435                 440                 445             


Asn Tyr Arg Leu Pro Gln Pro Ser Asn Cys Pro Gln Gln Phe Tyr Asn 
    450                 455                 460                 


Ile Met Leu Glu Cys Trp Asn Ala Glu Pro Lys Glu Arg Pro Thr Phe 
465                 470                 475                 480 


Glu Thr Leu Arg Trp Lys Leu Glu Asp Tyr Phe Glu Thr Asp Ser Ser 
                485                 490                 495     


Tyr Ser Asp Ala Asn Asn Phe Ile Arg 
            500                 505 


<210> 21
<211> 2794
<212> DNA
<213> Homo sapiens

<400> 21
cggcaggacc gagcgcggca ggcggctggc ccagcgcagc cagcgcggcc cgaaggacgg       60

gagcaggcgg ccgagcaccg agcgctgggc accgggcacc gagcggcggc ggcacgcgag      120

gcccggcccc gagcagcgcc cccgcccgcc gcggcctcca gcccggcccc gcccagcgcc      180

ggcccgcggg gatgcggagc ggcgggcgcc ggaggccgcg gcccggctag gcccgcgctc      240

gcgcccggac gcggcggccc gaggctgtgg ccaggccagc tgggctcggg gagcgccagc      300

ctgagaggag cgcgtgagcg tcgcgggagc ctcgggcacc atgagcgacg tggctattgt      360

gaaggagggt tggctgcaca aacgagggga gtacatcaag acctggcggc cacgctactt      420

cctcctcaag aatgatggca ccttcattgg ctacaaggag cggccgcagg atgtggacca      480

acgtgaggct cccctcaaca acttctctgt ggcgcagtgc cagctgatga agacggagcg      540

gccccggccc aacaccttca tcatccgctg cctgcagtgg accactgtca tcgaacgcac      600

cttccatgtg gagactcctg aggagcggga ggagtggaca accgccatcc agactgtggc      660

tgacggcctc aagaagcagg aggaggagga gatggacttc cggtcgggct cacccagtga      720

caactcaggg gctgaagaga tggaggtgtc cctggccaag cccaagcacc gcgtgaccat      780

gaacgagttt gagtacctga agctgctggg caagggcact ttcggcaagg tgatcctggt      840

gaaggagaag gccacaggcc gctactacgc catgaagatc ctcaagaagg aagtcatcgt      900

ggccaaggac gaggtggccc acacactcac cgagaaccgc gtcctgcaga actccaggca      960

ccccttcctc acagccctga agtactcttt ccagacccac gaccgcctct gctttgtcat     1020

ggagtacgcc aacgggggcg agctgttctt ccacctgtcc cgggagcgtg tgttctccga     1080

ggaccgggcc cgcttctatg gcgctgagat tgtgtcagcc ctggactacc tgcactcgga     1140

gaagaacgtg gtgtaccggg acctcaagct ggagaacctc atgctggaca aggacgggca     1200

cattaagatc acagacttcg ggctgtgcaa ggaggggatc aaggacggtg ccaccatgaa     1260

gaccttttgc ggcacacctg agtacctggc ccccgaggtg ctggaggaca atgactacgg     1320

ccgtgcagtg gactggtggg ggctgggcgt ggtcatgtac gagatgatgt gcggtcgcct     1380

gcccttctac aaccaggacc atgagaagct ttttgagctc atcctcatgg aggagatccg     1440

cttcccgcgc acgcttggtc ccgaggccaa gtccttgctt tcagggctgc tcaagaagga     1500

ccccaagcag aggcttggcg ggggctccga ggacgccaag gagatcatgc agcatcgctt     1560

ctttgccggt atcgtgtggc agcacgtgta cgagaagaag ctcagcccac ccttcaagcc     1620

ccaggtcacg tcggagactg acaccaggta ttttgatgag gagttcacgg cccagatgat     1680

caccatcaca ccacctgacc aagatgacag catggagtgt gtggacagcg agcgcaggcc     1740

ccacttcccc cagttctcct actcggccag cggcacggcc tgaggcggcg gtggactgcg     1800

ctggacgata gcttggaggg atggagaggc ggcctcgtgc catgatctgt atttaatggt     1860

ttttatttct cgggtgcatt tgagagaagc cacgctgtcc tctcgagccc agatggaaag     1920

acgtttttgt gctgtgggca gcaccctccc ccgcagcggg gtagggaaga aaactatcct     1980

gcgggtttta atttatttca tccagtttgt tctccgggtg tggcctcagc cctcagaaca     2040

atccgattca cgtagggaaa tgttaaggac ttctgcagct atgcgcaatg tggcattggg     2100

gggccgggca ggtcctgccc atgtgtcccc tcactctgtc agccagccgc cctgggctgt     2160

ctgtcaccag ctatctgtca tctctctggg gccctgggcc tcagttcaac ctggtggcac     2220

cagatgcaac ctcactatgg tatgctggcc agcaccctct cctgggggtg gcaggcacac     2280

agcagccccc cagcactaag gccgtgtctc tgaggacgtc atcggaggct gggcccctgg     2340

gatgggacca gggatggggg atgggccagg gtttacccag tgggacagag gagcaaggtt     2400

taaatttgtt attgtgtatt atgttgttca aatgcatttt gggggttttt aatctttgtg     2460

acaggaaagc cctccccctt ccccttctgt gtcacagttc ttggtgactg tcccaccggg     2520

agcctccccc tcagatgatc tctccacggt agcacttgac cttttcgacg cttaaccttt     2580

ccgctgtcgc cccaggccct ccctgactcc ctgtgggggt ggccatccct gggcccctcc     2640

acgcctcctg gccagacgct gccgctgccg ctgcaccacg gcgttttttt acaacattca     2700

actttagtat ttttactatt ataatataat atggaacctt ccctccaaat tcttcaataa     2760

aagttgcttt tcaaaaaaaa aaaaaaaaaa aaaa                                 2794


<210> 22
<211> 480
<212> PRT
<213> Homo sapiens

<400> 22
Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210> 23
<211> 5388
<212> DNA
<213> Homo sapiens

<400> 23
aaaatgttgg agatctgcct gaagctggtg ggctgcaaat ccaagaaggg gctgtcctcg       60

tcctccagct gttatctgga agaagccctt cagcggccag tagcatctga ctttgagcct      120

cagggtctga gtgaagccgc tcgttggaac tccaaggaaa accttctcgc tggacccagt      180

gaaaatgacc ccaacctttt cgttgcactg tatgattttg tggccagtgg agataacact      240

ctaagcataa ctaaaggtga aaagctccgg gtcttaggct ataatcacaa tggggaatgg      300

tgtgaagccc aaaccaaaaa tggccaaggc tgggtcccaa gcaactacat cacgccagtc      360

aacagtctgg agaaacactc ctggtaccat gggcctgtgt cccgcaatgc cgctgagtat      420

ctgctgagca gcgggatcaa tggcagcttc ttggtgcgtg agagtgagag cagtcctggc      480

cagaggtcca tctcgctgag atacgaaggg agggtgtacc attacaggat caacactgct      540

tctgatggca agctctacgt ctcctccgag agccgcttca acaccctggc cgagttggtt      600

catcatcatt caacggtggc cgacgggctc atcaccacgc tccattatcc agccccaaag      660

cgcaacaagc ccactgtcta tggtgtgtcc cccaactacg acaagtggga gatggaacgc      720

acggacatca ccatgaagca caagctgggc gggggccagt acggggaggt gtacgagggc      780

gtgtggaaga aatacagcct gacggtggcc gtgaagacct tgaaggagga caccatggag      840

gtggaagagt tcttgaaaga agctgcagtc atgaaagaga tcaaacaccc taacctggtg      900

cagctccttg gggtctgcac ccgggagccc ccgttctata tcatcactga gttcatgacc      960

tacgggaacc tcctggacta cctgagggag tgcaaccggc aggaggtgaa cgccgtggtg     1020

ctgctgtaca tggccactca gatctcgtca gccatggagt acctggagaa gaaaaacttc     1080

atccacagag atcttgctgc ccgaaactgc ctggtagggg agaaccactt ggtgaaggta     1140

gctgattttg gcctgagcag gttgatgaca ggggacacct acacagccca tgctggagcc     1200

aagttcccca tcaaatggac tgcacccgag agcctggcct acaacaagtt ctccatcaag     1260

tccgacgtct gggcatttgg agtattgctt tgggaaattg ctacctatgg catgtcccct     1320

tacccgggaa ttgacctgtc ccaggtgtat gagctgctag agaaggacta ccgcatggag     1380

cgcccagaag gctgcccaga gaaggtctat gaactcatgc gagcatgttg gcagtggaat     1440

ccctctgacc ggccctcctt tgctgaaatc caccaagcct ttgaaacaat gttccaggaa     1500

tccagtatct cagacgaagt ggaaaaggag ctggggaaac aaggcgtccg tggggctgtg     1560

agtaccttgc tgcaggcccc agagctgccc accaagacga ggacctccag gagagctgca     1620

gagcacagag acaccactga cgtgcctgag atgcctcact ccaagggcca gggagagagc     1680

gatcctctgg accatgagcc tgccgtgtct ccattgctcc ctcgaaaaga gcgaggtccc     1740

ccggagggcg gcctgaatga agatgagcgc cttctcccca aagacaaaaa gaccaacttg     1800

ttcagcgcct tgatcaagaa gaagaagaag acagccccaa cccctcccaa acgcagcagc     1860

tccttccggg agatggacgg ccagccggag cgcagagggg ccggcgagga agagggccga     1920

gacatcagca acggggcact ggctttcacc cccttggaca cagctgaccc agccaagtcc     1980

ccaaagccca gcaatggggc tggggtcccc aatggagccc tccgggagtc cgggggctca     2040

ggcttccggt ctccccacct gtggaagaag tccagcacgc tgaccagcag ccgcctagcc     2100

accggcgagg aggagggcgg tggcagctcc agcaagcgct tcctgcgctc ttgctccgcc     2160

tcctgcgttc cccatggggc caaggacacg gagtggaggt cagtcacgct gcctcgggac     2220

ttgcagtcca cgggaagaca gtttgactcg tccacatttg gagggcacaa aagtgagaag     2280

ccggctctgc ctcggaagag ggcaggggag aacaggtctg accaggtgac ccgaggcaca     2340

gtaacgcctc cccccaggct ggtgaaaaag aatgaggaag ctgctgatga ggtcttcaaa     2400

gacatcatgg agtccagccc gggctccagc ccgcccaacc tgactccaaa acccctccgg     2460

cggcaggtca ccgtggcccc tgcctcgggc ctcccccaca aggaagaagc tggaaagggc     2520

agtgccttag ggacccctgc tgcagctgag ccagtgaccc ccaccagcaa agcaggctca     2580

ggtgcaccag ggggcaccag caagggcccc gccgaggagt ccagagtgag gaggcacaag     2640

cactcctctg agtcgccagg gagggacaag gggaaattgt ccaggctcaa acctgccccg     2700

ccgcccccac cagcagcctc tgcagggaag gctggaggaa agccctcgca gagcccgagc     2760

caggaggcgg ccggggaggc agtcctgggc gcaaagacaa aagccacgag tctggttgat     2820

gctgtgaaca gtgacgctgc caagcccagc cagccgggag agggcctcaa aaagcccgtg     2880

ctcccggcca ctccaaagcc acagtccgcc aagccgtcgg ggacccccat cagcccagcc     2940

cccgttccct ccacgttgcc atcagcatcc tcggccctgg caggggacca gccgtcttcc     3000

accgccttca tccctctcat atcaacccga gtgtctcttc ggaaaacccg ccagcctcca     3060

gagcggatcg ccagcggcgc catcaccaag ggcgtggtcc tggacagcac cgaggcgctg     3120

tgcctcgcca tctctaggaa ctccgagcag atggccagcc acagcgcagt gctggaggcc     3180

ggcaaaaacc tctacacgtt ctgcgtgagc tatgtggatt ccatccagca aatgaggaac     3240

aagtttgcct tccgagaggc catcaacaaa ctggagaata atctccggga gcttcagatc     3300

tgcccggcga cagcaggcag tggtccagcg gccactcagg acttcagcaa gctcctcagt     3360

tcggtgaagg aaatcagtga catagtgcag aggtagcagc agtcaggggt caggtgtcag     3420

gcccgtcgga gctgcctgca gcacatgcgg gctcgcccat acccgtgaca gtggctgaca     3480

agggactagt gagtcagcac cttggcccag gagctctgcg ccaggcagag ctgagggccc     3540

tgtggagtcc agctctacta cctacgtttg caccgcctgc cctcccgcac cttcctcctc     3600

cccgctccgt ctctgtcctc gaattttatc tgtggagttc ctgctccgtg gactgcagtc     3660

ggcatgccag gacccgccag ccccgctccc acctagtgcc ccagactgag ctctccaggc     3720

caggtgggaa cggctgatgt ggactgtctt tttcattttt ttctctctgg agcccctcct     3780

cccccggctg ggcctccttc ttccacttct ccaagaatgg aagcctgaac tgaggccttg     3840

tgtgtcaggc cctctgcctg cactccctgg ccttgcccgt cgtgtgctga agacatgttt     3900

caagaaccgc atttcgggaa gggcatgcac gggcatgcac acggctggtc actctgccct     3960

ctgctgctgc ccggggtggg gtgcactcgc catttcctca cgtgcaggac agctcttgat     4020

ttgggtggaa aacagggtgc taaagccaac cagcctttgg gtcctgggca ggtgggagct     4080

gaaaaggatc gaggcatggg gcatgtcctt tccatctgtc cacatcccca gagcccagct     4140

cttgctctct tgtgacgtgc actgtgaatc ctggcaagaa agcttgagtc tcaagggtgg     4200

caggtcactg tcactgccga catccctccc ccagcagaat ggaggcaggg gacaagggag     4260

gcagtggcta gtggggtgaa cagctggtgc caaatagccc cagactgggc ccaggcaggt     4320

ctgcaagggc ccagagtgaa ccgtcctttc acacatctgg gtgccctgaa agggcccttc     4380

ccctccccca ctcctctaag acaaagtaga ttcttacaag gccctttcct ttggaacaag     4440

acagccttca cttttctgag ttcttgaagc atttcaaagc cctgcctctg tgtagccgcc     4500

ctgagagaga atagagctgc cactgggcac ctgcgcacag gtgggaggaa agggcctggc     4560

cagtcctggt cctggctgca ctcttgaact gggcgaatgt cttatttaat taccgtgagt     4620

gacatagcct catgttctgt gggggtcatc agggagggtt aggaaaacca caaacggagc     4680

ccctgaaagc ctcacgtatt tcacagagca cgcctgccat cttctccccg aggctgcccc     4740

aggccggagc ccagatacgg gggctgtgac tctgggcagg gacccggggt ctcctggacc     4800

ttgacagagc agctaactcc gagagcagtg ggcaggtggc cgcccctgag gcttcacgcc     4860

gggagaagcc accttcccac cccttcatac cgcctcgtgc cagcagcctc gcacaggccc     4920

tagctttacg ctcatcacct aaacttgtac tttatttttc tgatagaaat ggtttcctct     4980

ggatcgtttt atgcggttct tacagcacat cacctctttg cccccgacgg ctgtgacgca     5040

gccggaggga ggcactagtc accgacagcg gccttgaaga cagagcaaag cgcccaccca     5100

ggtcccccga ctgcctgtct ccatgaggta ctggtccctt ccttttgtta acgtgatgtg     5160

ccactatatt ttacacgtat ctcttggtat gcatctttta tagacgctct tttctaagtg     5220

gcgtgtgcat agcgtcctgc cctgccccct cgggggcctg tggtggctcc ccctctgctt     5280

ctcggggtcc agtgcatttt gtttctgtat atgattctct gtggtttttt ttgaatccaa     5340

atctgtcctc tgtagtattt tttaaataaa tcagtgttta cattagaa                  5388


<210> 24
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 24
Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210> 25
<211> 2033
<212> DNA
<213> Homo sapiens

<400> 25
atattgtata ctggaattga agccaaggag gtaccatttt gctcgagggc atggcctaag       60

ccggtcagct aaggccatgt taatacgggg ctgtcccatc tctctgcggg gcgcgacagc      120

tggaagagcc gaacggataa gagaagagga ggtgagagga gctgtacacc acaagaggca      180

ctgagggact caggataacg ggatgaagcc gtcagtgccc ccagaaacga agcggccccg      240

gacgaatttc tgagtcaccg tcgcgagaaa gcgggctgag ccgccatttt gaagcctggc      300

aaaccgaagc aagaaatgct gccgtgttgg atctttgcca gccttcgtgc cgaatgggag      360

cagggcgcgg atggcgtcgg ggcgccccga ggagctgtgg gaggccgtgg tgggggccgc      420

tgagcgcttc cgggcccgga ctggcacgga gctggtgctg ctgaccgcgg ccccgccgcc      480

accaccccgc ccgggcccct gtgcctatgc tgcccatggt cgaggagccc tggcggaggc      540

agcgcgccgt tgcctccacg acatcgcact ggcccacagg gctgccactg ctgctcggcc      600

tcctgcgccc ccaccagcac cacagccacc cagtcccaca cccagcccac cccggcctac      660

cctggccaga gaggacaacg aggaggacga ggatgagccc acagagacag agacctccgg      720

ggagcagctg ggcattagtg ataatggagg gctctttgtg atggatgagg acgccaccct      780

ccaggacctt ccccccttct gtgagtcaga ccccgagagt acagatgatg gcagcctgag      840

cgaggagacc cccgccggcc cccccacctg ctcagtgccc ccagcctcag ccctacccac      900

acagcagtac gccaagtccc tgcctgtgtc tgtgcccgtc tggggcttca aggagaagag      960

gacagaggcg cggtcatcag atgaggagaa tgggccgccc tcttcgcccg acctggaccg     1020

catcgcggcg agcatgcgcg cgctggtgct gcgagaggcc gaggacaccc aggtcttcgg     1080

ggacctgcca cggccgcggc ttaacaccag cgacttccag aagctgaagc ggaaatattg     1140

aagtccaggg agggagcgcc ccgggccgcg tccgccccgt cccacactac gcccccgccc     1200

cactcccggg gcctgctaat ctgaggccga tccgggaccg gcctccttgc gtctcccatt     1260

cccaagattg tcccgcctct gccaatcccc gccgtccttc cagcccacga cctgccgcgc     1320

cgaggagcgg catctgtccc gtttcccgat tgggtctgtc gtctctctcc gcctagcgac     1380

agattccttc tattaaggga ttggctcgct gagttctaag ctctaaatgg gtcaactcct     1440

ttgttttccg cctagcgaca agggatttgc tcgcacggca ttggctccat cccctagtcg     1500

ctggacagct ctttttttga ttggctcaaa tcctgtaaag ggcttgacca gtctctacat     1560

agtcaccgtc cgcttttcct gagttctccc tcccaattgg ctccagcttc ctgggggcgt     1620

ggccaagccc tcctcttccc agaattggcc cggggccttc aatttacgtt ctttacacta     1680

cggggactgg ggtcgtcttt gcccacgtcc cgacaacttg ttccctgacc ccctcaggga     1740

tggccccaaa ctgtccctgc ctctggcacc ccctttcatt ggttccatcc atccccacaa     1800

cagcctgcca atcgaagccc gtccctgcat ccaggatggt accagctccc gcccctcgcc     1860

ccccacctcc acaggtgcct taaagggccc tcgtccaccc aaggtggggg gcaggggccc     1920

tcactctccg gccctggtgt gggggagaga gtgaggggtt gggggatcgg cagttgggag     1980

gggcgctctg agattaaaga gttttacctc tgagataaaa aaaaaaaaaa aaa            2033


<210> 26
<211> 256
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210> 27
<211> 8733
<212> DNA
<213> Homo sapiens

<400> 27
gctcccggct tagaggacag cggggaaggc gggcggtggg gcagggggcc tgaagcggcg       60

gtaccggtgc tggcggcggc agctgaggcc ttggccgaag ccgcgcgaac ctcagggcaa      120

gatgcttgga accggacctg ccgccgccac caccgctgcc accacatcta gcaatgtgag      180

cgtcctgcag cagtttgcca gtggcctaaa gagccggaat gaggaaacca gggccaaagc      240

cgccaaggag ctccagcact atgtcaccat ggaactccga gagatgagtc aagaggagtc      300

tactcgcttc tatgaccaac tgaaccatca catttttgaa ttggtttcca gctcagatgc      360

caatgagagg aaaggtggca tcttggccat agctagcctc ataggagtgg aaggtgggaa      420

tgccacccga attggcagat ttgccaacta tcttcggaac ctcctcccct ccaatgaccc      480

agttgtcatg gaaatggcat ccaaggccat tggccgtctt gccatggcag gggacacttt      540

taccgctgag tacgtggaat ttgaggtgaa gcgagccctg gaatggctgg gtgctgaccg      600

caatgagggc cggagacatg cagctgtcct ggttctccgt gagctggcca tcagcgtccc      660

taccttcttc ttccagcaag tgcaaccctt ctttgacaac atttttgtgg ccgtgtggga      720

ccccaaacag gccatccgtg agggagctgt agccgccctt cgtgcctgtc tgattctcac      780

aacccagcgt gagccgaagg agatgcagaa gcctcagtgg tacaggcaca catttgaaga      840

agcagagaag ggatttgatg agaccttggc caaagagaag ggcatgaatc gggatgatcg      900

gatccatgga gccttgttga tccttaacga gctggtccga atcagcagca tggagggaga      960

gcgtctgaga gaagaaatgg aagaaatcac acagcagcag ctggtacacg acaagtactg     1020

caaagatctc atgggcttcg gaacaaaacc tcgtcacatt acccccttca ccagtttcca     1080

ggctgtacag ccccagcagt caaatgcctt ggtggggctg ctggggtaca gctctcacca     1140

aggcctcatg ggatttggga cctcccccag tccagctaag tccaccctgg tggagagccg     1200

gtgttgcaga gacttgatgg aggagaaatt tgatcaggtg tgccagtggg tgctgaaatg     1260

caggaatagc aagaactcgc tgatccaaat gacaatcctt aatttgttgc cccgcttggc     1320

tgcattccga ccttctgcct tcacagatac ccagtatctc caagatacca tgaaccatgt     1380

cctaagctgt gtcaagaagg agaaggaacg tacagcggcc ttccaagccc tggggctact     1440

ttctgtggct gtgaggtctg agtttaaggt ctatttgcct cgcgtgctgg acatcatccg     1500

agcggccctg cccccaaagg acttcgccca taagaggcag aaggcaatgc aggtggatgc     1560

cacagtcttc acttgcatca gcatgctggc tcgagcaatg gggccaggca tccagcagga     1620

tatcaaggag ctgctggagc ccatgctggc agtgggacta agccctgccc tcactgcagt     1680

gctctacgac ctgagccgtc agattccaca gctaaagaag gacattcaag atgggctact     1740

gaaaatgctg tccctggtcc ttatgcacaa accccttcgc cacccaggca tgcccaaggg     1800

cctggcccat cagctggcct ctcctggcct cacgaccctc cctgaggcca gcgatgtggg     1860

cagcatcact cttgccctcc gaacgcttgg cagctttgaa tttgaaggcc actctctgac     1920

ccaatttgtt cgccactgtg cggatcattt cctgaacagt gagcacaagg agatccgcat     1980

ggaggctgcc cgcacctgct cccgcctgct cacaccctcc atccacctca tcagtggcca     2040

tgctcatgtg gttagccaga ccgcagtgca agtggtggca gatgtgctta gcaaactgct     2100

cgtagttggg ataacagatc ctgaccctga cattcgctac tgtgtcttgg cgtccctgga     2160

cgagcgcttt gatgcacacc tggcccaggc ggagaacttg caggccttgt ttgtggctct     2220

gaatgaccag gtgtttgaga tccgggagct ggccatctgc actgtgggcc gactcagtag     2280

catgaaccct gcctttgtca tgcctttcct gcgcaagatg ctcatccaga ttttgacaga     2340

gttggagcac agtgggattg gaagaatcaa agagcagagt gcccgcatgc tggggcacct     2400

ggtctccaat gccccccgac tcatccgccc ctacatggag cctattctga aggcattaat     2460

tttgaaactg aaagatccag accctgatcc aaacccaggt gtgatcaata atgtcctggc     2520

aacaatagga gaattggcac aggttagtgg cctggaaatg aggaaatggg ttgatgaact     2580

ttttattatc atcatggaca tgctccagga ttcctctttg ttggccaaaa ggcaggtggc     2640

tctgtggacc ctgggacagt tggtggccag cactggctat gtagtagagc cctacaggaa     2700

gtaccctact ttgcttgagg tgctactgaa ttttctgaag actgagcaga accagggtac     2760

acgcagagag gccatccgtg tgttagggct tttaggggct ttggatcctt acaagcacaa     2820

agtgaacatt ggcatgatag accagtcccg ggatgcctct gctgtcagcc tgtcagaatc     2880

caagtcaagt caggattcct ctgactatag cactagtgaa atgctggtca acatgggaaa     2940

cttgcctctg gatgagttct acccagctgt gtccatggtg gccctgatgc ggatcttccg     3000

agaccagtca ctctctcatc atcacaccat ggttgtccag gccatcacct tcatcttcaa     3060

gtccctggga ctcaaatgtg tgcagttcct gccccaggtc atgcccacgt tccttaacgt     3120

cattcgagtc tgtgatgggg ccatccggga atttttgttc cagcagctgg gaatgttggt     3180

gtcctttgtg aagagccaca tcagacctta tatggatgaa atagtcaccc tcatgagaga     3240

attctgggtc atgaacacct caattcagag cacgatcatt cttctcattg agcaaattgt     3300

ggtagctctt gggggtgaat ttaagctcta cctgccccag ctgatcccac acatgctgcg     3360

tgtcttcatg catgacaaca gcccaggccg cattgtctct atcaagttac tggctgcaat     3420

ccagctgttt ggcgccaacc tggatgacta cctgcattta ctgctgcctc ctattgttaa     3480

gttgtttgat gcccctgaag ctccactgcc atctcgaaag gcagcgctag agactgtgga     3540

ccgcctgacg gagtccctgg atttcactga ctatgcctcc cggatcattc accctattgt     3600

tcgaacactg gaccagagcc cagaactgcg ctccacagcc atggacacgc tgtcttcact     3660

tgtttttcag ctggggaaga agtaccaaat tttcattcca atggtgaata aagttctggt     3720

gcgacaccga atcaatcatc agcgctatga tgtgctcatc tgcagaattg tcaagggata     3780

cacacttgct gatgaagagg aggatccttt gatttaccag catcggatgc ttaggagtgg     3840

ccaaggggat gcattggcta gtggaccagt ggaaacagga cccatgaaga aactgcacgt     3900

cagcaccatc aacctccaaa aggcctgggg cgctgccagg agggtctcca aagatgactg     3960

gctggaatgg ctgagacggc tgagcctgga gctgctgaag gactcatcat cgccctccct     4020

gcgctcctgc tgggccctgg cacaggccta caacccgatg gccagggatc tcttcaatgc     4080

tgcatttgtg tcctgctggt ctgaactgaa tgaagatcaa caggatgagc tcatcagaag     4140

catcgagttg gccctcacct cacaagacat cgctgaagtc acacagaccc tcttaaactt     4200

ggctgaattc atggaacaca gtgacaaggg ccccctgcca ctgagagatg acaatggcat     4260

tgttctgctg ggtgagagag ctgccaagtg ccgagcatat gccaaagcac tacactacaa     4320

agaactggag ttccagaaag gccccacccc tgccattcta gaatctctca tcagcattaa     4380

taataagcta cagcagccgg aggcagcggc cggagtgtta gaatatgcca tgaaacactt     4440

tggagagctg gagatccagg ctacctggta tgagaaactg cacgagtggg aggatgccct     4500

tgtggcctat gacaagaaaa tggacaccaa caaggacgac ccagagctga tgctgggccg     4560

catgcgctgc ctcgaggcct tgggggaatg gggtcaactc caccagcagt gctgtgaaaa     4620

gtggaccctg gttaatgatg agacccaagc caagatggcc cggatggctg ctgcagctgc     4680

atggggttta ggtcagtggg acagcatgga agaatacacc tgtatgatcc ctcgggacac     4740

ccatgatggg gcattttata gagctgtgct ggcactgcat caggacctct tctccttggc     4800

acaacagtgc attgacaagg ccagggacct gctggatgct gaattaactg cgatggcagg     4860

agagagttac agtcgggcat atggggccat ggtttcttgc cacatgctgt ccgagctgga     4920

ggaggttatc cagtacaaac ttgtccccga gcgacgagag atcatccgcc agatctggtg     4980

ggagagactg cagggctgcc agcgtatcgt agaggactgg cagaaaatcc ttatggtgcg     5040

gtcccttgtg gtcagccctc atgaagacat gagaacctgg ctcaagtatg caagcctgtg     5100

cggcaagagt ggcaggctgg ctcttgctca taaaacttta gtgttgctcc tgggagttga     5160

tccgtctcgg caacttgacc atcctctgcc aacagttcac cctcaggtga cctatgccta     5220

catgaaaaac atgtggaaga gtgcccgcaa gatcgatgcc ttccagcaca tgcagcattt     5280

tgtccagacc atgcagcaac aggcccagca tgccatcgct actgaggacc agcagcataa     5340

gcaggaactg cacaagctca tggcccgatg cttcctgaaa cttggagagt ggcagctgaa     5400

tctacagggc atcaatgaga gcacaatccc caaagtgctg cagtactaca gcgccgccac     5460

agagcacgac cgcagctggt acaaggcctg gcatgcgtgg gcagtgatga acttcgaagc     5520

tgtgctacac tacaaacatc agaaccaagc ccgcgatgag aagaagaaac tgcgtcatgc     5580

cagcggggcc aacatcacca acgccaccac tgccgccacc acggccgcca ctgccaccac     5640

cactgccagc accgagggca gcaacagtga gagcgaggcc gagagcaccg agaacagccc     5700

caccccatcg ccgctgcaga agaaggtcac tgaggatctg tccaaaaccc tcctgatgta     5760

cacggtgcct gccgtccagg gcttcttccg ttccatctcc ttgtcacgag gcaacaacct     5820

ccaggataca ctcagagttc tcaccttatg gtttgattat ggtcactggc cagatgtcaa     5880

tgaggcctta gtggaggggg tgaaagccat ccagattgat acctggctac aggttatacc     5940

tcagctcatt gcaagaattg atacgcccag acccttggtg ggacgtctca ttcaccagct     6000

tctcacagac attggtcggt accaccccca ggccctcatc tacccactga cagtggcttc     6060

taagtctacc acgacagccc ggcacaatgc agccaacaag attctgaaga acatgtgtga     6120

gcacagcaac accctggtcc agcaggccat gatggtgagc gaggagctga tccgagtggc     6180

catcctctgg catgagatgt ggcatgaagg cctggaagag gcatctcgtt tgtactttgg     6240

ggaaaggaac gtgaaaggca tgtttgaggt gctggagccc ttgcatgcta tgatggaacg     6300

gggcccccag actctgaagg aaacatcctt taatcaggcc tatggtcgag atttaatgga     6360

ggcccaagag tggtgcagga agtacatgaa atcagggaat gtcaaggacc tcacccaagc     6420

ctgggacctc tattatcatg tgttccgacg aatctcaaag cagctgcctc agctcacatc     6480

cttagagctg caatatgttt ccccaaaact tctgatgtgc cgggaccttg aattggctgt     6540

gccaggaaca tatgacccca accagccaat cattcgcatt cagtccatag caccgtcttt     6600

gcaagtcatc acatccaagc agaggccccg gaaattgaca cttatgggca gcaacggaca     6660

tgagtttgtt ttccttctaa aaggccatga agatctgcgc caggatgagc gtgtgatgca     6720

gctcttcggc ctggttaaca cccttctggc caatgaccca acatctcttc ggaaaaacct     6780

cagcatccag agatacgctg tcatcccttt atcgaccaac tcgggcctca ttggctgggt     6840

tccccactgt gacacactgc acgccctcat ccgggactac agggagaaga agaagatcct     6900

tctcaacatc gagcatcgca tcatgttgcg gatggctccg gactatgacc acttgactct     6960

gatgcagaag gtggaggtgt ttgagcatgc cgtcaataat acagctgggg acgacctggc     7020

caagctgctg tggctgaaaa gccccagctc cgaggtgtgg tttgaccgaa gaaccaatta     7080

tacccgttct ttagcggtca tgtcaatggt tgggtatatt ttaggcctgg gagatagaca     7140

cccatccaac ctgatgctgg accgtctgag tgggaagatc ctgcacattg actttgggga     7200

ctgctttgag gttgctatga cccgagagaa gtttccagag aagattccat ttagactaac     7260

aagaatgttg accaatgcta tggaggttac aggcctggat ggcaactaca gaatcacatg     7320

ccacacagtg atggaggtgc tgcgagagca caaggacagt gtcatggccg tgctggaagc     7380

ctttgtctat gaccccttgc tgaactggag gctgatggac acaaatacca aaggcaacaa     7440

gcgatcccga acgaggacgg attcctactc tgctggccag tcagtcgaaa ttttggacgg     7500

tgtggaactt ggagagccag cccataagaa aacggggacc acagtgccag aatctattca     7560

ttctttcatt ggagacggtt tggtgaaacc agaggcccta aataagaaag ctatccagat     7620

tattaacagg gttcgagata agctcactgg tcgggacttc tctcatgatg acactttgga     7680

tgttccaacg caagttgagc tgctcatcaa acaagcgaca tcccatgaaa acctctgcca     7740

gtgctatatt ggctggtgcc ctttctggta actggaggcc cagatgtgcc catcacgttt     7800

tttctgaggc ttttgtactt tagtaaatgc ttccactaaa ctgaaaccat ggtgagaaag     7860

tttgactttg ttaaatattt tgaaatgtaa atgaaaagaa ctactgtata ttaaaagttg     7920

gtttgaacca actttctagc tgctgttgaa gaatatattg tcagaaacac aaggcttgat     7980

ttggttccca ggacagtgaa acatagtaat accacgtaaa tcaagccatt cattttgggg     8040

aacagaagat ccataacttt agaaatacgg gttttgactt aactcacaag agaactcatc     8100

ataagtactt gctgatggaa gaatgaccta gttgctcctc tcaacatggg tacagcaaac     8160

tcagcacagc caagaagcct caggtcgtgg agaacatgga ttaggatcct agactgtaaa     8220

gacacagaag atgctgacct cacccctgcc acctatccca agacctcact ggtctgtgga     8280

cagcagcaga aatgtttgca agataggcca aaatgagtac aaaaggtctg tcttccatca     8340

gacccagtga tgctgcgact cacacgcttc aattcaagac ctgaccgcta gtagggaggt     8400

ttattcagat cgctggcagc ctcggctgag cagatgcaca gaggggatca ctgtgcagtg     8460

ggaccaccct cactggcctt ctgcagcagg gttctgggat gttttcagtg gtcaaaatac     8520

tctgtttaga gcaagggctc agaaaacaga aatactgtca tggaggtgct gaacacaggg     8580

aaggtctggt acatattgga aattatgagc agaacaaata ctcaactaaa tgcacaaagt     8640

ataaagtgta gccatgtcta gacaccatgt tgtatcagaa taatttttgt gccaataaat     8700

gacatcagaa ttttaaacat atgtaaaaaa aaa                                  8733


<210> 28
<211> 2549
<212> PRT
<213> Homo sapiens

<400> 28
Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210> 29
<211> 5299
<212> DNA
<213> Homo sapiens

<400> 29
gtttggcttc acggaaccct gtacgcatgc tcctacgctg aactttagga gccagtctaa       60

ggcctaggcg cagacgcact gagcctaagc agccggtgat ggcggcagcg gctgtggtgg      120

ctgcggcggg tccgggccca tgaggcgacg aaggaggcgg gacggctttt acccagcccc      180

ggacttccga gacagggaag ctgaggacat ggcaggagtg tttgacatag acctggacca      240

gccagaggac gcgggctctg aggatgagct ggaggagggg ggtcagttaa atgaaagcat      300

ggaccatggg ggagttggac catatgaact tggcatggaa cattgtgaga aatttgaaat      360

ctcagaaact agtgtgaaca gagggccaga aaaaatcaga ccagaatgtt ttgagctact      420

tcgggtactt ggtaaagggg gctatggaaa ggcaatgata gtaagaaatg ctaaagatac      480

agctcataca aaagcagaac ggaatattct ggaggaagta aagcatccct tcatcgtgga      540

tttaatttat gcctttcaga ctggtggaaa actctacctc atccttgagt atctcagtgg      600

aggagaacta tttatgcagt tagaaagaga gggaatattt atggaagaca ctgcctgctt      660

ttacttggca gaaatctcca tggctttggg gcatttacat caaaagggga tcatctacag      720

agacctgaag ccggagaata tcatgcttaa tcaccaaggt catgtgaaac taacagactt      780

tggactatgc aaagaatcta ttcatgatgg aacagtcaca cacacatttt gtggaacaat      840

agaatacatg gcccctgaaa tcttgatgag aagtggccac aatcgtgctg tggattggtg      900

gagtttggga gcattaatgt atgacatgct gactggagca cccccattca ctggggagaa      960

tagaaagaaa acaattgaca aaatcctcaa atgtaaactc aatttgcctc cctacctcac     1020

acaagaagcc agagatctgc ttaaaaagct gctgaaaaga aatgctgctt ctcgtctggg     1080

agctggtcct ggggacgctg gagaagttca agctcatcca ttctttagac acattaactg     1140

ggaagaactt ctggctcgaa aggtggagcc cccctttaaa cctctgttgc aatctgaaga     1200

ggatgtaagt cagtttgatt ccaagtttac acgtcagaca cctgtcgaca gcccagatga     1260

ctcaactctc agtgaaagtg ccaatcaggt ctttctgggt tttacatatg tggctccatc     1320

tgtacttgaa agtgtgaaag aaaagttttc ctttgaacca aaaatccgat cacctcgaag     1380

atttattggc agcccacgaa cacctgtcag cccagtcaaa ttttctcctg gggatttctg     1440

gggaagaggt gcttcggcca gcacagcaaa tcctcagaca cctgtggaat acccaatgga     1500

aacaagtggc atagagcaga tggatgtgac aatgagtggg gaagcatcgg caccacttcc     1560

aatacgacag ccgaactctg ggccatacaa aaaacaagct tttcccatga tctccaaacg     1620

gccagagcac ctgcgtatga atctatgaca gagcaatgct tttaatgaat ttaaggcaaa     1680

aaaggtggag agggagatgt gtgagcatcc tgcaaggtga aacgactcaa aatgacagtt     1740

tcagagagtc aatgtcatta catagaacac ttcagacaca ggaaaaataa acgtggattt     1800

taaaaaatca atcaatggtg caaaaaaaaa cttaaagcaa aatagtattg ctgaactctt     1860

aggcacatca attaattgat tcctcgcgac atcttctcaa ccttatcaag gattttcatg     1920

ttgatgactc gaaactgaca gtattaaggg taggatgttg cttctgaatc actgttgagt     1980

tctgattgtg ttgaagaagg gttatccttt cattaggcaa agtacaaaat tgcctataat     2040

acttgcaact aaggacaaat tagcatgcaa gcttggtcaa actttttcca gcaaaatgga     2100

agcaaagaca aaagaaactt accaattgat gttttacgtg caaacaacct gaatcttttt     2160

tttatataaa tatatatttt tcaaatagat ttttgattca gctcattatg aaaaacatcc     2220

caaactttaa aatgcgaaat tattggttgg tgtgaagaaa gccagacaac ttctgtttct     2280

tctcttggtg aaataataaa atgcaaatga atcattgtta accacagctg tggctcgttt     2340

gagggattgg ggtggacctg gggtttattt tcagtaaccc agctgcaata cctgtctgta     2400

atatgagaaa aaaaaaatga atctatttaa tcatttctac ttgcagtact gctatgtgct     2460

aagcttaact ggaagccttg gaatgggcat aagttgtatg tcctacattt catcattgtc     2520

ccgggcctgc attgcactgg aaaaaaaaat cgccacctgt tcttacacca gtatttggtt     2580

caagacacca aatgtcttca gcccatggct gaagaacaac agaagagagt caggataaaa     2640

aatacatact gtggtcggca aggtgaggga gatagggata tccaggggaa gagggtgttg     2700

ctgtggccca ctctctgtct aatctcttta cagcaaattg gtaagatttt cagttttact     2760

tctttctact gtttctgctg tctaccttcc ttatattttt ttcctcaaca gttttaaaaa     2820

gaaaaaaagg tctatttttt tttctcctat acttgggcta cattttttga ttgtaaaaat     2880

atttgatggc cttttgatga atgtcttcca cagtaaagaa aacttagtgg cttaatttag     2940

gaaacatgtt aacaggacac tatgtttttg aaattgtaac aaaatctaca taaatgattt     3000

acaggttaaa agaataaaaa taaaggtaac tttacctttc ttaaatattt cctgccttaa     3060

agagagcatt tccatgactt tagctggtga aagggtttaa tatctgcaga gctttataaa     3120

aatatatttc agtgcatact ggtataatag atgatcatgc agttgcagtt gagttgtatc     3180

accttttttg tttgtctttt ataatgtctt cagtctgagt gtgcaaagtc aatttgtaat     3240

attttgcaac cctaggattt ttttaaatag atgctgcttg ctatgttttc aaaccttttt     3300

gagccatagg atccaagcca taaaattctt tatgcatgtt gaattcagtc agaaaagagc     3360

aaggctttgc tttttgaaat tgcaactcaa atgagatggg atgaaatcct atgacagtaa     3420

gcaaaaacag aaccatgaaa aatgattgga catacacctt ttcaattgtg gcaataattg     3480

aaagaatcga taaaagttca tctttggaca gaaagccttt aaaaaaaaaa tcactccctc     3540

ttccccctcc tcccttattg cagcagccta ctgagaactt tgactgttgc tggtaaatta     3600

gaagctacaa taataattaa gggcagaaat tatacttaaa aagtgcagat ccttgttctt     3660

tgacaatttg tgatgtctga aaaaacagaa cccgaaaagc tatggtgata tgtacaggca     3720

ttatttcaga ctgtaaatgg cttgtgatac tcttgatact tgttttcaaa tatgtttact     3780

aactgtagtg ttgactgcct gaccaaattc cagtgaaact tatacaccaa aatattcttc     3840

ctaggtccta tttgctagta acatgagcac tgtgattggc tggctataac caccccagtt     3900

aaaccatttt cataattagt agtgccagca atagtggcaa acactgcaac ttttctgcat     3960

aaaaagcatt aattgcacag ctaccatcca cacaaataca tagtttttct gacttcacat     4020

ttattaagtg aaatttattt cccatgctgt ggaaagttta ttgagaactt gtttcataaa     4080

tggatatccc tactatgact gtgaaaacat gtcaagtgtc acattagtgt cacagacaga     4140

aagcacacac ctatgcaata tggcttatct atatttattt gtaaaaatcc aagcatagtt     4200

taaaatatga tgtcgatatt actagtcttg agtttctaag agggttcttt atgttatacc     4260

aggtaagtgt ataaaagaga ttaagtgctt ttttttcatc acttgattat tttctttaaa     4320

atcagctatt acaggatatt tttttatttt atacatgctg ttttttaatt aaaatataat     4380

cactgaagtt tactaatttg attttataag gtttgtagca ttacagaata actaaactgg     4440

gatttataaa ccagctgtga ttaacaatgt aaagtattaa ttattgaact ttgaaccaga     4500

tttttaggaa aattatgttc tttttccccc tttatggtct taactaattt gaatccttca     4560

agaaggattt ttccatacta ttttttaaga tagaagataa tttgtgggca ggggtggagg     4620

atgcatgtat gatactccat aaattcaaca ttctttacta taggtaatga atgattataa     4680

acaagatgca tcttagatag tattaatata ctgagccttg gattatatat ttaatatagg     4740

acctattttg aatattcagt taatcatatg gttcctagct tacaagggct agatctaaga     4800

ttattcccat gagaaatgtt gaatttatga agaatagatt ttaaggcttt gaaaatggtt     4860

aatttctcaa aaacatcaat gtccaaacat ctaccttttt tcataggagt agacactagc     4920

aagctggaca aactatcaca aaagtatttg tcacacataa cctgtggtct gttgctgatt     4980

aatacagtac tttttcttgt gtgattctta acattatagc acaagtatta tctcagtgga     5040

ttatccggaa taacatctga aagatgggtt catctatgtt tgtgtttgct ctttaaacta     5100

ttgtttctcc tatcccaagt tcgctttgca tctatcagta aataaaattc ttcagctgcc     5160

ttattaggag tgctatgagg gtaacacctg ttctgctttt catcttgtat ttagttgact     5220

gtattatttg atttcggatt gaatgaatgt aaatagaaat taaatgcaaa tttgaatgaa     5280

cataaaaaaa aaaaaaaaa                                                  5299


<210> 30
<211> 502
<212> PRT
<213> Homo sapiens

<400> 30
Met Arg Arg Arg Arg Arg Arg Asp Gly Phe Tyr Pro Ala Pro Asp Phe 
1               5                   10                  15      


Arg Asp Arg Glu Ala Glu Asp Met Ala Gly Val Phe Asp Ile Asp Leu 
            20                  25                  30          


Asp Gln Pro Glu Asp Ala Gly Ser Glu Asp Glu Leu Glu Glu Gly Gly 
        35                  40                  45              


Gln Leu Asn Glu Ser Met Asp His Gly Gly Val Gly Pro Tyr Glu Leu 
    50                  55                  60                  


Gly Met Glu His Cys Glu Lys Phe Glu Ile Ser Glu Thr Ser Val Asn 
65                  70                  75                  80  


Arg Gly Pro Glu Lys Ile Arg Pro Glu Cys Phe Glu Leu Leu Arg Val 
                85                  90                  95      


Leu Gly Lys Gly Gly Tyr Gly Lys Ala Met Ile Val Arg Asn Ala Lys 
            100                 105                 110         


Asp Thr Ala His Thr Lys Ala Glu Arg Asn Ile Leu Glu Glu Val Lys 
        115                 120                 125             


His Pro Phe Ile Val Asp Leu Ile Tyr Ala Phe Gln Thr Gly Gly Lys 
    130                 135                 140                 


Leu Tyr Leu Ile Leu Glu Tyr Leu Ser Gly Gly Glu Leu Phe Met Gln 
145                 150                 155                 160 


Leu Glu Arg Glu Gly Ile Phe Met Glu Asp Thr Ala Cys Phe Tyr Leu 
                165                 170                 175     


Ala Glu Ile Ser Met Ala Leu Gly His Leu His Gln Lys Gly Ile Ile 
            180                 185                 190         


Tyr Arg Asp Leu Lys Pro Glu Asn Ile Met Leu Asn His Gln Gly His 
        195                 200                 205             


Val Lys Leu Thr Asp Phe Gly Leu Cys Lys Glu Ser Ile His Asp Gly 
    210                 215                 220                 


Thr Val Thr His Thr Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu 
225                 230                 235                 240 


Ile Leu Met Arg Ser Gly His Asn Arg Ala Val Asp Trp Trp Ser Leu 
                245                 250                 255     


Gly Ala Leu Met Tyr Asp Met Leu Thr Gly Ala Pro Pro Phe Thr Gly 
            260                 265                 270         


Glu Asn Arg Lys Lys Thr Ile Asp Lys Ile Leu Lys Cys Lys Leu Asn 
        275                 280                 285             


Leu Pro Pro Tyr Leu Thr Gln Glu Ala Arg Asp Leu Leu Lys Lys Leu 
    290                 295                 300                 


Leu Lys Arg Asn Ala Ala Ser Arg Leu Gly Ala Gly Pro Gly Asp Ala 
305                 310                 315                 320 


Gly Glu Val Gln Ala His Pro Phe Phe Arg His Ile Asn Trp Glu Glu 
                325                 330                 335     


Leu Leu Ala Arg Lys Val Glu Pro Pro Phe Lys Pro Leu Leu Gln Ser 
            340                 345                 350         


Glu Glu Asp Val Ser Gln Phe Asp Ser Lys Phe Thr Arg Gln Thr Pro 
        355                 360                 365             


Val Asp Ser Pro Asp Asp Ser Thr Leu Ser Glu Ser Ala Asn Gln Val 
    370                 375                 380                 


Phe Leu Gly Phe Thr Tyr Val Ala Pro Ser Val Leu Glu Ser Val Lys 
385                 390                 395                 400 


Glu Lys Phe Ser Phe Glu Pro Lys Ile Arg Ser Pro Arg Arg Phe Ile 
                405                 410                 415     


Gly Ser Pro Arg Thr Pro Val Ser Pro Val Lys Phe Ser Pro Gly Asp 
            420                 425                 430         


Phe Trp Gly Arg Gly Ala Ser Ala Ser Thr Ala Asn Pro Gln Thr Pro 
        435                 440                 445             


Val Glu Tyr Pro Met Glu Thr Ser Gly Ile Glu Gln Met Asp Val Thr 
    450                 455                 460                 


Met Ser Gly Glu Ala Ser Ala Pro Leu Pro Ile Arg Gln Pro Asn Ser 
465                 470                 475                 480 


Gly Pro Tyr Lys Lys Gln Ala Phe Pro Met Ile Ser Lys Arg Pro Glu 
                485                 490                 495     


His Leu Arg Met Asn Leu 
            500         


<210> 31
<211> 3112
<212> DNA
<213> Homo sapiens

<400> 31
ccccggactc tgcctgctcc tgccatggtg ccgtggccct gctgggcgga tggagcagga       60

tcccaagccg ccccgtctgc ggctctgggc cctgatcccc tggcttccca ggaagcagcg      120

gcccaggatc agccagacct ctctgcctgt ccctggccct ggctctggcc cccagcggga      180

ctcggatgag ggcgtcctca aggagatctc catcacgcac cacgtcaagg ctggctctga      240

gaaggctgat ccatcccatt tcgagctcct caaggttctg ggccagggat cctttggcaa      300

agtcttcctg gtgcggaaag tcacccggcc tgacagtggg cacctgtatg ctatgaaggt      360

gctgaagaag gcaacgctga aagtacgtga ccgcgtccgg accaagatgg agagagacat      420

cctggctgat gtaaatcacc cattcgtggt gaagctgcac tatgccttcc agaccgaggg      480

caagctctat ctcattctgg acttcctgcg tggtggggac ctcttcaccc ggctctcaaa      540

agaggtgatg ttcacggagg aggatgtgaa gttttacctg gccgagctgg ctctgggcct      600

ggatcacctg cacagcctgg gtatcattta cagagacctc aagcctgaga acatccttct      660

ggatgaggag ggccacatca aactcactga ctttggcctg agcaaagagg ccattgacca      720

cgagaagaag gcctattctt tctgcgggac agtggagtac atggcccctg aggtcgtcaa      780

ccgccagggc cactcccata gtgcggactg gtggtcctat ggggtgttga tgtttgagat      840

gctgacgggc tccctgccct tccaggggaa ggaccggaag gagaccatga cactgattct      900

gaaggcgaag ctaggcatgc cccagtttct gagcactgaa gcccagagcc tcttgcgggc      960

cctgttcaag cggaatcctg ccaaccggct cggctccggc cctgatgggg cagaggaaat     1020

caagcggcat gtcttctact ccaccattga ctggaataag ctataccgtc gtgagatcaa     1080

gccacccttc aagccagcag tggctcagcc tgatgacacc ttctactttg acaccgagtt     1140

cacgtcccgc acacccaagg attccccagg catccccccc agcgctgggg cccatcagct     1200

gttccggggc ttcagcttcg tggccaccgg cctgatggaa gacgacggca agcctcgtgc     1260

cccgcaggca cccctgcact cggtggtaca gcaactccat gggaagaacc tggtttttag     1320

tgacggctac gtggtaaagg agacaattgg tgtgggctcc tactctgagt gcaagcgctg     1380

tgtccacaag gccaccaaca tggagtatgc tgtcaaggtc attgataaga gcaagcggga     1440

tccttcagaa gagattgaga ttcttctgcg gtatggccag caccccaaca tcatcactct     1500

gaaagatgtg tatgatgatg gcaaacacgt gtacctggtg acagagctga tgcggggtgg     1560

ggagctgctg gacaagatcc tgcggcagaa gttcttctca gagcgggagg ccagctttgt     1620

cctgcacacc attggcaaaa ctgtggagta tctgcactca cagggggttg tgcacaggga     1680

cctgaagccc agcaacatcc tgtatgtgga cgagtccggg aatcccgagt gcctgcgcat     1740

ctgtgacttt ggttttgcca aacagctgcg ggctgagaat gggctcctca tgacaccttg     1800

ctacacagcc aactttgtgg cgcctgaggt gctgaagcgc cagggctacg atgaaggctg     1860

cgacatctgg agcctgggca ttctgctgta caccatgctg gcaggatata ctccatttgc     1920

caacggtccc agtgacacac cagaggaaat cctaacccgg atcggcagtg ggaagtttac     1980

cctcagtggg ggaaattgga acacagtttc agagacagcc aaggacctgg tgtccaagat     2040

gctacacgtg gatccccacc agcgcctcac agctaagcag gttctgcagc atccatgggt     2100

cacccagaaa gacaagcttc cccaaagcca gctgtcccac caggacctac agcttgtgaa     2160

gggagccatg gctgccacgt actccgcact caacagctcc aagcccaccc cccagctgaa     2220

gcccatcgag tcatccatcc tggcccagcg gcgagtgagg aagttgccat ccaccaccct     2280

gtgaggcacc agggcattcg ggccacaggg cggtgctagc ttgacacagt cagcatgctt     2340

cccagaggga gcaggccgga accacagggc cagagggagc tggaacccga ggggccgggg     2400

aagctgccag cccagaacac ccctaatgag ggtgtgagaa gtgccttctc cttccccagg     2460

atggactctt ctcggctcag gctctgctgg tggaaagcga ttcactgtat aaactttttt     2520

ttatgaaaaa aatggcatca accaccatgg atttttacaa gatccatttg cctttctggg     2580

agcagaaaca gccattgcgg ccccaggagg ggaactgagt cacgctgggg ctctctgaga     2640

ctctttagag cagctttggg atcccaccct ggggaccccc acgattggcc acctgtagcc     2700

atctgcacac acctccgaga cagtccagtg tcacctctct cagagcatct ggctgtttag     2760

cagaactcat tctatcccca atcagctcct tttccgttct gttctgctgg gagttctaga     2820

accacttcct gctacaggag gggtctcatg tcctgctggc ttccagcttc aggcaccagc     2880

atccaccttg gctctgccag tggatcccct gcggtcaggc tgggcagccc cagagagagg     2940

atgtggaaag cactttttgg ctgacttcat ctggggttgg caacaggaca gagttcacag     3000

gaggccagtg ggcgggccat gagggacagg gtcttttttc atttcttcct cagctggtta     3060

ctcagggttc atctgtccat ggcctttcta ataaactgtt gagttgaagc ac             3112


<210> 32
<211> 744
<212> PRT
<213> Homo sapiens

<400> 32
Met Glu Gln Asp Pro Lys Pro Pro Arg Leu Arg Leu Trp Ala Leu Ile 
1               5                   10                  15      


Pro Trp Leu Pro Arg Lys Gln Arg Pro Arg Ile Ser Gln Thr Ser Leu 
            20                  25                  30          


Pro Val Pro Gly Pro Gly Ser Gly Pro Gln Arg Asp Ser Asp Glu Gly 
        35                  40                  45              


Val Leu Lys Glu Ile Ser Ile Thr His His Val Lys Ala Gly Ser Glu 
    50                  55                  60                  


Lys Ala Asp Pro Ser His Phe Glu Leu Leu Lys Val Leu Gly Gln Gly 
65                  70                  75                  80  


Ser Phe Gly Lys Val Phe Leu Val Arg Lys Val Thr Arg Pro Asp Ser 
                85                  90                  95      


Gly His Leu Tyr Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val 
            100                 105                 110         


Arg Asp Arg Val Arg Thr Lys Met Glu Arg Asp Ile Leu Ala Asp Val 
        115                 120                 125             


Asn His Pro Phe Val Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly 
    130                 135                 140                 


Lys Leu Tyr Leu Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr 
145                 150                 155                 160 


Arg Leu Ser Lys Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr 
                165                 170                 175     


Leu Ala Glu Leu Ala Leu Gly Leu Asp His Leu His Ser Leu Gly Ile 
            180                 185                 190         


Ile Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly 
        195                 200                 205             


His Ile Lys Leu Thr Asp Phe Gly Leu Ser Lys Glu Ala Ile Asp His 
    210                 215                 220                 


Glu Lys Lys Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met Ala Pro 
225                 230                 235                 240 


Glu Val Val Asn Arg Gln Gly His Ser His Ser Ala Asp Trp Trp Ser 
                245                 250                 255     


Tyr Gly Val Leu Met Phe Glu Met Leu Thr Gly Ser Leu Pro Phe Gln 
            260                 265                 270         


Gly Lys Asp Arg Lys Glu Thr Met Thr Leu Ile Leu Lys Ala Lys Leu 
        275                 280                 285             


Gly Met Pro Gln Phe Leu Ser Thr Glu Ala Gln Ser Leu Leu Arg Ala 
    290                 295                 300                 


Leu Phe Lys Arg Asn Pro Ala Asn Arg Leu Gly Ser Gly Pro Asp Gly 
305                 310                 315                 320 


Ala Glu Glu Ile Lys Arg His Val Phe Tyr Ser Thr Ile Asp Trp Asn 
                325                 330                 335     


Lys Leu Tyr Arg Arg Glu Ile Lys Pro Pro Phe Lys Pro Ala Val Ala 
            340                 345                 350         


Gln Pro Asp Asp Thr Phe Tyr Phe Asp Thr Glu Phe Thr Ser Arg Thr 
        355                 360                 365             


Pro Lys Asp Ser Pro Gly Ile Pro Pro Ser Ala Gly Ala His Gln Leu 
    370                 375                 380                 


Phe Arg Gly Phe Ser Phe Val Ala Thr Gly Leu Met Glu Asp Asp Gly 
385                 390                 395                 400 


Lys Pro Arg Ala Pro Gln Ala Pro Leu His Ser Val Val Gln Gln Leu 
                405                 410                 415     


His Gly Lys Asn Leu Val Phe Ser Asp Gly Tyr Val Val Lys Glu Thr 
            420                 425                 430         


Ile Gly Val Gly Ser Tyr Ser Glu Cys Lys Arg Cys Val His Lys Ala 
        435                 440                 445             


Thr Asn Met Glu Tyr Ala Val Lys Val Ile Asp Lys Ser Lys Arg Asp 
    450                 455                 460                 


Pro Ser Glu Glu Ile Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn 
465                 470                 475                 480 


Ile Ile Thr Leu Lys Asp Val Tyr Asp Asp Gly Lys His Val Tyr Leu 
                485                 490                 495     


Val Thr Glu Leu Met Arg Gly Gly Glu Leu Leu Asp Lys Ile Leu Arg 
            500                 505                 510         


Gln Lys Phe Phe Ser Glu Arg Glu Ala Ser Phe Val Leu His Thr Ile 
        515                 520                 525             


Gly Lys Thr Val Glu Tyr Leu His Ser Gln Gly Val Val His Arg Asp 
    530                 535                 540                 


Leu Lys Pro Ser Asn Ile Leu Tyr Val Asp Glu Ser Gly Asn Pro Glu 
545                 550                 555                 560 


Cys Leu Arg Ile Cys Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Glu 
                565                 570                 575     


Asn Gly Leu Leu Met Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro 
            580                 585                 590         


Glu Val Leu Lys Arg Gln Gly Tyr Asp Glu Gly Cys Asp Ile Trp Ser 
        595                 600                 605             


Leu Gly Ile Leu Leu Tyr Thr Met Leu Ala Gly Tyr Thr Pro Phe Ala 
    610                 615                 620                 


Asn Gly Pro Ser Asp Thr Pro Glu Glu Ile Leu Thr Arg Ile Gly Ser 
625                 630                 635                 640 


Gly Lys Phe Thr Leu Ser Gly Gly Asn Trp Asn Thr Val Ser Glu Thr 
                645                 650                 655     


Ala Lys Asp Leu Val Ser Lys Met Leu His Val Asp Pro His Gln Arg 
            660                 665                 670         


Leu Thr Ala Lys Gln Val Leu Gln His Pro Trp Val Thr Gln Lys Asp 
        675                 680                 685             


Lys Leu Pro Gln Ser Gln Leu Ser His Gln Asp Leu Gln Leu Val Lys 
    690                 695                 700                 


Gly Ala Met Ala Ala Thr Tyr Ser Ala Leu Asn Ser Ser Lys Pro Thr 
705                 710                 715                 720 


Pro Gln Leu Lys Pro Ile Glu Ser Ser Ile Leu Ala Gln Arg Arg Val 
                725                 730                 735     


Arg Lys Leu Pro Ser Thr Thr Leu 
            740                 


<210> 33
<211> 7723
<212> DNA
<213> Homo sapiens

<400> 33
atgccgctgg cgcagctggc ggacccgtgg cagaagatgg ctgtggagag cccgtccgac       60

agcgctgaga atggacagca aattatggat gaacctatgg gagaggagga gattaaccca      120

caaactgaag aagtcagtat caaagaaatt gcaatcacac atcatgtaaa ggaaggacat      180

gaaaaggcag atccttccca gtttgaactt ttaaaagtat tagggcaggg atcatttgga      240

aaggttttct tagttaaaaa aatctcaggc tctgatgcta ggcagcttta tgccatgaag      300

gtattgaaga aggccacact gaaagttcga gaccgagttc ggacaaaaat ggaacgtgat      360

atcttggtag aggttaatca tccttttatt gtcaagttgc attatgcttt tcaaactgaa      420

gggaagttgt atcttatttt ggattttctc aggggaggag atttgtttac acgcttatcc      480

aaagaggtga tgttcacaga agaagatgtc aaattctact tggctgaact tgcacttgct      540

ttagaccatc tacatagcct gggaataatt tatagagact taaaaccaga aaatatactt      600

cttgatgaag aaggtcacat caagttaaca gatttcggcc taagtaaaga gtctattgac      660

catgaaaaga aggcatattc tttttgtgga actgtggagt atatggctcc agaagtagtt      720

aatcgtcgag gtcatactca gagtgctgac tggtggtctt ttggtgtgtt aatgtttgaa      780

atgcttactg gtacactccc tttccaagga aaagatcgaa aagaaacaat gactatgatt      840

cttaaagcca aacttggaat gccacagttt ttgagtcctg aagcgcagag tcttttacga      900

atgcttttca agcgaaatcc tgcaaacaga ttaggtgcag gaccagatgg agttgaagaa      960

attaaaagac attcattttt ctcaacgata gactggaata aactgtatag aagagaaatt     1020

catccgccat ttaaacctgc aacgggcagg cctgaagata cattctattt tgatcctgag     1080

tttactgcaa aaactcccaa agattcacct ggcattccac ctagtgctaa tgcacatcag     1140

ctttttcggg ggtttagttt tgttgctatt acctcagatg atgaaagcca agctatgcag     1200

acagttggtg tacattcaat tgttcagcag ttacacagga acagtattca gtttactgat     1260

ggatatgaag taaaagaaga tattggagtt ggctcctact ctgtttgcaa gagatgtata     1320

cataaagcta caaacatgga gtttgcagtg aagattattg ataaaagcaa gagagaccca     1380

acagaagaaa ttgaaattct tcttcgttat ggacagcatc caaacattat cactctaaag     1440

gatgtatatg atgatggaaa gtatgtgtat gtagtaacag aacttatgaa aggaggtgaa     1500

ttgctggata aaattcttag acaaaaattt ttctctgaac gagaggccag tgctgtcctg     1560

ttcactataa ctaaaaccgt tgaatatctt cacgcacaag gggtggttca tagagacttg     1620

aaacctagca acattcttta tgtggatgaa tctggtaatc cggaatctat tcgaatttgt     1680

gattttggct ttgcaaaaca gctgagagcg gaaaatggtc ttctcatgac tccttgttac     1740

actgcaaatt ttgttgcacc agaggtttta aaaagacaag gctatgatgc tgcttgtgat     1800

atatggagtc ttggtgtcct actctataca atgcttaccg gttacactcc atttgcaaat     1860

ggtcctgatg atacaccaga ggaaatattg gcacgaatag gtagcggaaa attctcactc     1920

agtggtggtt actggaattc tgtttcagac acagcaaagg acctggtgtc aaagatgctt     1980

catgtagacc ctcatcagag actgactgct gctcttgtgc tcagacatcc ttggatcgtc     2040

cactgggacc aactgccaca ataccaacta aacagacagg atgcaccaca tctagtaaag     2100

ggtgccatgg cagctacata ttctgctttg aaccgtaatc agtcaccagt tttggaacca     2160

gtaggccgct ctactcttgc tcagcggaga ggtattaaaa aaatcacctc aacagccctg     2220

tgaagtgacc tcagtgagat atttggtacc atggtgtaag ctgatagcac aagttctggc     2280

gacaggtagc acgtatctga gagacacctg caagcacaca ctgtcccagc tggtacccat     2340

aatgctgctg ttcctgctgc tgctcctgct ttcctctctt ctcgctttaa atgattgtta     2400

gcaagttaga ttttcctgga gcttcggaag aaatgaaaat ggaaacatga tgaagatata     2460

gtcactgaat caatgagaaa aataatgaac atatgaatac cacctaaaaa tacactgaat     2520

aaagtacacc atatagcatt atttttatag gaaatatttc atgtccctta aatattcttt     2580

gttagttata gggatggaca gtttatgtta agcacttagc ttaaacaatc cgtttatatt     2640

agcactgtat cccttgtgcc atccaacatt ttgtatgttt ttgtaaacag ttcatataca     2700

gtacatttct gtactgcttt ctttaatgta tacatgcctt gtttaacttg gaatctatta     2760

ttattaatca attgactatt aaatctggtt aaatagttca cctggattaa cagtattgtt     2820

ggacagtcct aaaaatggcc agattgtgga acagctgttg aatgtaatac ttccaaaatg     2880

tacatatctt tccccacgtc tgtttcactg gttcgttcat ttgtttgttt cttaaagtca     2940

ggtgctctgt cagactaacc tagagagctg ttatggtaga gaaagttatc atatgtgtgt     3000

ggcatgaaat caagaataca cctatgaagt tagtccatat actttgcaac tccttagagt     3060

acttttttcc ttaattaagg aagtagtcct tgcacttcta atcttacata gcatccatac     3120

ttagaatttg gcatatcatc tgggattttg ccaatatacg tcaaagccct ttaagagtca     3180

tggtaaggag atgggtgaag gaaaatttag caacaggtaa ttgaagtcct attggatatt     3240

tcatgtttaa atagatattc tatattaaac actaatttaa atgtaataaa ggccaaaggc     3300

ctctgtatga aattggattt aaactttctt attttaggga ataaaacatt attgatcaaa     3360

cagtatctgt tctaacctaa aattataggt agggcaggct aagtgaacag cattgagtat     3420

tttctgaatc cctcatgata atttatagcc acatactgct tcctttgact tcaggaatga     3480

tcagttttca taatggccac tgggcctgct tagattgcag tattcattat ctgcatctaa     3540

tttggtagtt tccacaatcg tatttgatga aagaaacttc agtccccatt attacctgtg     3600

tctttgccaa gctgcctagc atacatcagt atgtaatgta aaagacatat gagcaagaaa     3660

aaagtgattt aacttacctc atcaagaatg tgcccctaca ggccgggcgc agtggctcac     3720

gcctgtaatc ccagcatttt gggaggccga ggcaggtgga tcacctgagg tcaggagttt     3780

gagaccagcc tggccaacat ggtgaaaccc cgtctctact aaaaaataca aaaattagct     3840

gggcatggtg gcgtgcacct gtaatcctag ctactcagga ggctgaggca ggagaatcgc     3900

ttgaacctgg gaggtggtgg ttgcagtgag ccaagatcac accattgcac tccagcctgg     3960

gtgacagagt gagactctgt ctcaagaagg aaaaaaaaaa aaaagaatgt actcatacag     4020

atttttgtta gtcatcatgt aataagccat ttatatcaga aacctttttt cctgccacag     4080

aagctttaaa ttttccccta agagtacaaa gccaagagag tgtggtttat ctaaatgtcc     4140

tgaaatccac ttgtcattcc ttaatttctc ctctatgcaa ttaaagagaa aggggaaatc     4200

tataacattt cttttgccca agtgacacaa aaatgattac tgcatagaaa tcaaatgtaa     4260

gtttagcttc taaatgaaat aatatatagg agggatatca gaatgtctag atagagaaag     4320

tattttcaaa ttcttgaata tatggatgct attaaaagct gctttccatt gcctggaaag     4380

agagcttttt tccctcctct attcagtgtt tcaaactttg gtcatctcaa attattgtca     4440

cttttaaaat gttaatgtca ttctgagcag aaatagatat attttcagat ttttttacac     4500

tgatgctact ccgtaattgc ttaggagtat tgtccatcat agtattttag aactagaagt     4560

aaacacataa atccttataa attacccaat ccaactttct catattgcat gtagagaacc     4620

tgagacacat atcaaagtct agaatcctta acttctcccc attttgtttt tttccgcctc     4680

atcacaccat gctgcctttc cctcatatga tcaccaacca gtagctgagt tcaaaaacta     4740

catatttctt gggcagtcct ctactggtat gtgatgccaa cttttatttc tttcgaagat     4800

aattgccttc tttgcctagc caagcagcca attttattgg agaaaagcaa gttatatgtt     4860

cacaaaatgg aaggctttct acctaaattt atttcatctg tggtcctctt attctcttcc     4920

attgcttttg acatacagtg gaaaaacttg gccaacgatg tgctctaaat atagtgcttg     4980

tgttgggtta acttttccat taatttctca acatcaatta ttcaggcccc tacagttgtg     5040

gtattgaggc ccctaaaggc ttctgccttt caccaattag tgctgccagt tactgaggct     5100

tctcccaaaa ggtatcagtc cagtcttaaa gatatttcat tgtgaaagaa gaaactaaac     5160

tatcaggcct cttttacaaa atgagagatt gaatttaagc ttgtcaagca cgtactggaa     5220

ggtatgaatt acactaccat gtgttttgta tcttcccttt caagtgatga tgttaaatga     5280

aggtaagttt ttcatccttt tttaattttt gttttttata aatcatttca gctttttctg     5340

gtttatagag gtgtcttatt tctaatgcaa cagaccccca actttaacag atttgatatg     5400

gatgcattta ttcacaagca accccaaaag tccaaaaatg taataatttt gacaaggccc     5460

aaagttgaga tgctatgaag cttgtgtgtg tgaaaagtca gttatgattg tctggagaga     5520

agctgtggtg tgtatgctgt agagtttcca catttcacat gcagtgtact ccaaaaagcg     5580

ggtttgggtc aaccatttcc catctctttt taagaagtga ctgctgttgg ggccagggga     5640

catcatggga ggtggggctg tccagttagc tgtgccctgc accttcagcc caggaaagat     5700

ttgaacagag caaaggcttc aagagagggc agaatgtatt cggcagaaaa gggactcagg     5760

taagcccagc ctgggatgag agcagaaaag cattcaagat ttgcaggcct tgctatggat     5820

gcgcttaatc accatggagg ccagcaatac ccatctcagc atggctttga tattctctac     5880

ttcctggcct ttaaaaatga cctataattt ttcagtttgc tttactatat tttataaaga     5940

aaattctatc ttatggttga ttgagcattg agacttatga aggcattagg atagatagct     6000

caggaatgta aaggttcaga aaaggtctgt tttctcagat taacaaatat gatggattcc     6060

atggctgacc ttggtgctta aaccaggagg tttcaatcta gtcctagagt tgtgtccctc     6120

tgaaaggccc aatgccatgt aactaacttt aaactggata tatactttga gccttactta     6180

attcacagat aagttgactt aactcagtat ttttatttca attaatgaaa acagtcctct     6240

tttcaacccc aggttgctta cattttgctg gtctccccaa gtgaccattg gtggagacca     6300

attaatgaag gaatgaaatt cactttattg ggactgtggt attcaacaga gccacactta     6360

accacttttt ccaatgaaga atctccagaa tgataatgcc caaatatgga tggccaagaa     6420

gaatttgtat ctacggtgtg ctttatgtgt ttttgacact gctgtattct gtgtgatcaa     6480

gtgatttgca gctggttcca atgtgactga gtgttctcaa agatttctag taactaagtc     6540

aacttaattt tcttaagcct ggtattacta tcagcctcac atttaccact ttgattctag     6600

ttttttaact gttcataaca gggcataccg agggttggga tgagagccta cttcctacct     6660

cttaaggcac tttcctcatt attttgccat ataatcttga actgcatgat aagctgttta     6720

aatgtccatg acttctccca gagcaactag caaagtatat gacattttga atagagatta     6780

gtggaaagga aaatgtagag atttaagttc agaggtacaa acctcaataa aacctcctta     6840

gagcacatac catgagtaga gtatatgtaa acgtatatga gaagagagtc gctataatag     6900

tcctctctaa gtagattagt tcattgtcta atggaagtga acatctttac tcctgttatc     6960

accatagtac tgaatgaact gtataatgag tttttcaaac aagtatttaa aatagaactt     7020

tcacgtacaa agcaagggca taaagatttt ggtttgtgtt tctgtaagtg tagtttacca     7080

tctaaagctt tggtttttaa ttttaaaaaa agcttcaagg tattgccatt ccttagcatc     7140

cttattgatt atgggtgatg agtttttaac tcttaaaatc atatacgtgt attagtttat     7200

cttaactgtt gccctaagca aaagggaagg tatacaccta agggatgtac ttattttgca     7260

tttttggtca tgggtgggaa tggggtgggt gcctacttaa atagttttta aaaaagaaaa     7320

aaatcacaaa tatttttcta ctgttatata tgatcttcct ttatactagt ttctctctag     7380

taaggcatgc cagaagccca agataccata tcatgaattc ttacatattg taccttttgt     7440

tggtggttaa atcgcatcag atgcttggca ttgctgccat aattataaaa tgcttgtaaa     7500

ggatcaaata tcactaaata ctttaaattg ttttacttaa gagtctaatc tgggaagttt     7560

tcaaatcata ctattaatgt gtaatctaag ctcttcagat gtatccatga ataatcctgg     7620

aacaatattg cttgtattcc tgtcatagaa caggttttgt aatctttaaa agaaatgaaa     7680

atttatataa taaagtttca aatcaatgca aaaaaaaaaa aaa                       7723


<210> 34
<211> 740
<212> PRT
<213> Homo sapiens

<400> 34
Met Pro Leu Ala Gln Leu Ala Asp Pro Trp Gln Lys Met Ala Val Glu 
1               5                   10                  15      


Ser Pro Ser Asp Ser Ala Glu Asn Gly Gln Gln Ile Met Asp Glu Pro 
            20                  25                  30          


Met Gly Glu Glu Glu Ile Asn Pro Gln Thr Glu Glu Val Ser Ile Lys 
        35                  40                  45              


Glu Ile Ala Ile Thr His His Val Lys Glu Gly His Glu Lys Ala Asp 
    50                  55                  60                  


Pro Ser Gln Phe Glu Leu Leu Lys Val Leu Gly Gln Gly Ser Phe Gly 
65                  70                  75                  80  


Lys Val Phe Leu Val Lys Lys Ile Ser Gly Ser Asp Ala Arg Gln Leu 
                85                  90                  95      


Tyr Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val Arg Asp Arg 
            100                 105                 110         


Val Arg Thr Lys Met Glu Arg Asp Ile Leu Val Glu Val Asn His Pro 
        115                 120                 125             


Phe Ile Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly Lys Leu Tyr 
    130                 135                 140                 


Leu Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr Leu Ala Glu 
                165                 170                 175     


Leu Ala Leu Ala Leu Asp His Leu His Ser Leu Gly Ile Ile Tyr Arg 
            180                 185                 190         


Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly His Ile Lys 
        195                 200                 205             


Leu Thr Asp Phe Gly Leu Ser Lys Glu Ser Ile Asp His Glu Lys Lys 
    210                 215                 220                 


Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met Ala Pro Glu Val Val 
225                 230                 235                 240 


Asn Arg Arg Gly His Thr Gln Ser Ala Asp Trp Trp Ser Phe Gly Val 
                245                 250                 255     


Leu Met Phe Glu Met Leu Thr Gly Thr Leu Pro Phe Gln Gly Lys Asp 
            260                 265                 270         


Arg Lys Glu Thr Met Thr Met Ile Leu Lys Ala Lys Leu Gly Met Pro 
        275                 280                 285             


Gln Phe Leu Ser Pro Glu Ala Gln Ser Leu Leu Arg Met Leu Phe Lys 
    290                 295                 300                 


Arg Asn Pro Ala Asn Arg Leu Gly Ala Gly Pro Asp Gly Val Glu Glu 
305                 310                 315                 320 


Ile Lys Arg His Ser Phe Phe Ser Thr Ile Asp Trp Asn Lys Leu Tyr 
                325                 330                 335     


Arg Arg Glu Ile His Pro Pro Phe Lys Pro Ala Thr Gly Arg Pro Glu 
            340                 345                 350         


Asp Thr Phe Tyr Phe Asp Pro Glu Phe Thr Ala Lys Thr Pro Lys Asp 
        355                 360                 365             


Ser Pro Gly Ile Pro Pro Ser Ala Asn Ala His Gln Leu Phe Arg Gly 
    370                 375                 380                 


Phe Ser Phe Val Ala Ile Thr Ser Asp Asp Glu Ser Gln Ala Met Gln 
385                 390                 395                 400 


Thr Val Gly Val His Ser Ile Val Gln Gln Leu His Arg Asn Ser Ile 
                405                 410                 415     


Gln Phe Thr Asp Gly Tyr Glu Val Lys Glu Asp Ile Gly Val Gly Ser 
            420                 425                 430         


Tyr Ser Val Cys Lys Arg Cys Ile His Lys Ala Thr Asn Met Glu Phe 
        435                 440                 445             


Ala Val Lys Ile Ile Asp Lys Ser Lys Arg Asp Pro Thr Glu Glu Ile 
    450                 455                 460                 


Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu Lys 
465                 470                 475                 480 


Asp Val Tyr Asp Asp Gly Lys Tyr Val Tyr Val Val Thr Glu Leu Met 
                485                 490                 495     


Lys Gly Gly Glu Leu Leu Asp Lys Ile Leu Arg Gln Lys Phe Phe Ser 
            500                 505                 510         


Glu Arg Glu Ala Ser Ala Val Leu Phe Thr Ile Thr Lys Thr Val Glu 
        515                 520                 525             


Tyr Leu His Ala Gln Gly Val Val His Arg Asp Leu Lys Pro Ser Asn 
    530                 535                 540                 


Ile Leu Tyr Val Asp Glu Ser Gly Asn Pro Glu Ser Ile Arg Ile Cys 
545                 550                 555                 560 


Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Glu Asn Gly Leu Leu Met 
                565                 570                 575     


Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys Arg 
            580                 585                 590         


Gln Gly Tyr Asp Ala Ala Cys Asp Ile Trp Ser Leu Gly Val Leu Leu 
        595                 600                 605             


Tyr Thr Met Leu Thr Gly Tyr Thr Pro Phe Ala Asn Gly Pro Asp Asp 
    610                 615                 620                 


Thr Pro Glu Glu Ile Leu Ala Arg Ile Gly Ser Gly Lys Phe Ser Leu 
625                 630                 635                 640 


Ser Gly Gly Tyr Trp Asn Ser Val Ser Asp Thr Ala Lys Asp Leu Val 
                645                 650                 655     


Ser Lys Met Leu His Val Asp Pro His Gln Arg Leu Thr Ala Ala Leu 
            660                 665                 670         


Val Leu Arg His Pro Trp Ile Val His Trp Asp Gln Leu Pro Gln Tyr 
        675                 680                 685             


Gln Leu Asn Arg Gln Asp Ala Pro His Leu Val Lys Gly Ala Met Ala 
    690                 695                 700                 


Ala Thr Tyr Ser Ala Leu Asn Arg Asn Gln Ser Pro Val Leu Glu Pro 
705                 710                 715                 720 


Val Gly Arg Ser Thr Leu Ala Gln Arg Arg Gly Ile Lys Lys Ile Thr 
                725                 730                 735     


Ser Thr Ala Leu 
            740 


<210> 35
<211> 5735
<212> DNA
<213> Homo sapiens

<400> 35
gcgtcccttg gcttccgaca tcccgtctgg ccgtccccct gtgccggtcc gagcctctgt       60

ttatttcctt tcctactatc aatactcgac cagcagaaaa ggaaagttta aaaatgccaa      120

tcgcacagtt gctggaacta tggaaaaaga tcgaggtgga gcctatggaa atagagacca      180

cagaggagga tctcaacctg gatgtggagc ccaccacaga agacactgca gaagaagaag      240

aaggcgtcgt gaaggagata gacatcagcc atcatgtgaa ggagggcttt gagaaggcag      300

atccttccca gtttgagctg ctgaaggttt taggacaagg atcctatgga aaggtgttcc      360

tggtgaggaa ggtgaagggg tccgacgctg ggcagctcta cgccatgaag gtccttaaga      420

aagccaccct aaaagttcgg gaccgagtga gatcgaagat ggagagagac atcttggcag      480

aagtgaatca ccccttcatt gtgaagcttc attatgcctt tcagacggaa ggaaagctct      540

acctgatcct ggacttcctg cggggagggg acctcttcac ccggctctcc aaagaggtca      600

tgttcacgga ggaggatgtc aagttctacc tggctgagct ggccttggct ttagaccatc      660

tccacagcct ggggatcatc tacagagatc tgaagcctga gaacatcctc ctggatgaag      720

aggggcacat taagatcaca gatttcggcc tgagtaagga ggccattgac cacgacaaga      780

gagcgtactc cttctgcggg acgatcgagt acatggcgcc cgaggtggtg aaccggcgag      840

gacacacgca gagtgccgac tggtggtcct tcggcgtgct catgtttgag atgctcacgg      900

ggtccctgcc gttccagggg aaggacagga aggagaccat ggctctcatc ctcaaagcca      960

agctggggat gccgcagttc ctcagtgggg aggcacagag tttgctgcga gctctcttca     1020

aacggaaccc ctgcaaccgg ctgggtgctg gcattgacgg agtggaggaa attaagcgcc     1080

atcccttctt tgtgaccata gactggaaca cgctgtaccg gaaggagatc aagccaccgt     1140

tcaaaccagc agtgggcagg cctgaggaca ccttccactt tgaccccgag ttcacagcgc     1200

ggacgcccac agactctcct ggcgtccccc cgagtgcaaa cgctcatcac ctgtttagag     1260

gattcagctt tgtggcctca agcctgatcc aggagccctc acagcaagat ctgcacaaag     1320

tcccagttca cccaatcgtg cagcagttac acgggaacaa catccacttc accgatggct     1380

acgagatcaa ggaggacatc ggggtgggct cctactcagt gtgcaagcga tgtgtgcata     1440

aagccacaga caccgagtat gccgtgaaga tcattgataa gagcaagaga gacccctcgg     1500

aagagattga gatcctcctg cggtacggcc agcacccgaa catcatcacc ctcaaggatg     1560

tctatgatga tggcaagttt gtgtacctgg taatggagct gatgcgtggt ggggagctcc     1620

tggaccgcat cctccggcag agatacttct cggagcgcga agccagtgac gtcctgtgca     1680

ccatcaccaa gaccatggac tacctccatt cccagggggt tgttcatcga gacctgaagc     1740

cgagtaacat cctgtacagg gatgagtcgg ggagcccaga atccatccga gtctgcgact     1800

tcggctttgc caagcagctg cgcgcgggga acgggctgct catgacaccc tgctacacgg     1860

ccaatttcgt ggccccggag gtcctgaagc gtcaaggcta tgatgcggcg tgtgacatct     1920

ggagtttggg gatcctgttg tacaccatgc tggcaggatt tacccctttt gcaaatgggc     1980

cagacgatac ccctgaggag attctggcgc ggatcggcag tgggaagtat gccctttctg     2040

ggggaaactg ggactcgata tctgacgcag ctaaagacgt cgtgtccaag atgctccacg     2100

tggaccctca tcagcgcctg acggcgatgc aagtgctcaa acacccgtgg gtggtcaaca     2160

gagagtacct gtccccaaac cagctcagcc gacaggacgt gcacctggtg aagggcgcga     2220

tggccgccac ctactttgct ctaaacagaa cacctcaggc cccgcggctg gagcccgtgc     2280

tgtcatccaa cctggctcag cgcagaggca tgaagagact cacgtccacg cggctgtagc     2340

gggtgggacc ctggccccag cgtcccctgc cagcatcctc gtgggctcac agaccccggc     2400

ctcggagccc gtctggcacc cagagtgacc acaagtccag cagggaggcg gcgcccgccc     2460

tcgccgtgtc cgtgttttct ttttcagccc cggagagggt cctgacctgg gggcttctcc     2520

aagcctcact gcgccagcct ccccgcccgc tctcttttct cccaagcgaa accaaatgcg     2580

ccccttcacc tcgcgtgccc gtgcgaggcc gggggcttct ttcagagccc gcgggtcctc     2640

tcatacatgg cttctgtttc tgccgagaga tctgttttcc aattatgaag ccggtcggtt     2700

tggtcagact cccgacaccc acgtcccagg tacccggtgg gaaagtggca gtgcgagggc     2760

gcagccattg gtggttgcag ggccccagag ggctggggtg acctggcatc ccggggctcc     2820

ccacgggctg gatgacgggg ttggcactgt ggcgtccagg aggagatgcc tggttctgcc     2880

caaaataatc caaagagccg tttcctcctc gcccttcagt ttttgcctga ggtgctgggt     2940

agcccatcct ttcctctgtc ccagattcaa atgaggagta agagcccaga cgagaggaag     3000

gcaggctgga tctttgcctt gagagctccg tgtcaccagg atggaagggg gtgcctctcg     3060

gaggagcctg tgtccacctc cagtctcggc tttccccggg gggccaagcg cactgggctg     3120

ccgtctgtcc ccagctcccg tggccacaca gctatctgga ggctttgcag ggagtcgtgg     3180

gttctcgcac ctgctcagcc ctgtgtcggc ttcctgtgtg ctcacctaaa gctgtggttt     3240

tgctgtgttc acttcgattt ttctggtctg tggagaaact gtgaattgga gaaatggagc     3300

tctgtggctt cccacccaaa ccttctcagt ccagctggag gctggaggga gacacaggcc     3360

ccacccagca gactgagggg cagaggcaca ggtgggaggg cagcggagat cagcgtggac     3420

aggagcgatg cactttgtag atgctgtggc tttgtgttgc gttttgtgtc tctgttgcac     3480

agatctgttt tttcacactg atccgtattc ccctgggtgt gcacacaggg cgggtgtggg     3540

gcatttaggc catgctgtgc tctacttcat tgagtaaaat cgagtgagag gttccgggca     3600

gcaggatcga cgcccagtcc agccggcaga gggaacacac gggtccttca ttgtcctgta     3660

agggtgttga agatgctccc tggcggcccc caagcagact agatgggagg aggcgccgct     3720

cagcccctca ccctgcatca ctgaagagcg gcgcctctgc agcaagcagg gcttcaggag     3780

gtgcccgctg gccacagcca ggttttccct aagaagatgt tattttgttg ggttttgttc     3840

cccctccatc tcgattctcg tacccaacta aaaaaaaaaa aataaagaaa aaatgtgctg     3900

cgttctgaaa aataactcct tagcttggtc tgattgtttt cagaccttaa aatataaact     3960

tgtttcacaa gctttaatcc atgtggattt tttttttctt agagaaccac aaaacataaa     4020

aggagcaagt cggactgaat acctgtttcc atagtgccca cagggtattc ctcacatttt     4080

ctccatagaa gatgcttttt cccaaggcta gaacgacttc caccatgatg aatttgcttt     4140

ttaggtctta attatttcac ttctttttag aaacttagga agaagtggat aatcctgagg     4200

tcacacaatc tgtcctccca gaaatgaaca aaagtcatca ccttttctgc ttgctacaca     4260

ggcaacgatt cccccatcag ctgcccggac cctttggcct ggcttggtgt gcaggcctgt     4320

ctgtttgctt aaagtcagtg ggttctggtg cagggagtga gaagtggggg aagtgaaagg     4380

gaaagcatcc gtgagaaagc ggccacggtt ttccctcctt gtgtgcccat ggggcaccag     4440

ctcatggtct ttttcagtca tcccagtttg tacagactta gcttctgaac tctaagaatg     4500

ccaaagggac cgacgagact ccccatcaca gcgagctctg tccttacatg tatttgatgt     4560

gcatcagcgg aggagaacac tggcttggcc ctgctccgct gagtgtctgt gaaatacctc     4620

tactttccct cccatatcca gaacaaaatg atacttgaca tccttccaca aaagtcagcc     4680

taaagaagtt atggtatcat atgttaaact aagctttcaa aaaccttagt gaaatagcaa     4740

gtgactgctt tcaagcagca gtcgacatgt aaatgaaggt gttcttagaa ttcgcatttt     4800

gccagctcag cgcacctcca caacgaatga aatgctccgt atgatttgca caaatgacat     4860

agacctcccc aaaagttaac tggctctcct tcctcacaca gttcatcata acccaacccc     4920

ccacccccgg gtcatgaaaa tcacagaact tataaacaca ttgaacccta gatctcaggc     4980

ttcctgacct accgccagtg gccccttgct ggccacccta tagggtcctc cttccctggc     5040

agccccccat gtgggagaaa tacctgattc tcccaatctg cagtgggaga gctttgctga     5100

attccatccc aaagtcaaac atgggcaaga ggtgaggatt tcacttttac cctcaagtcc     5160

gatttgtctg tgattttaaa ctaactgtgt atgtattgat gtttggaaga ttgtttgaat     5220

tttaaagtga taatagtact taatgttatc cagtattgtt cattaaatgg tgttatccta     5280

aagctgcact tgggattttt acctaacgct ttactgattc tctcaagcac atggcaaagt     5340

ttgatttgca ctccgttcat ttctgacacg ttttgctgcc tcctaccttt ctaagcgtca     5400

tgcaaattcg agaatggaga aggacgctgc cggtccctga gcggtgtgga gagggcggaa     5460

ggtggactcc agcgcagctt gaggggctga ggacggaggc tgcagcatct gtgtcgttct     5520

actgagcacg cttctctgcc tcgctcctga ctcagcactt tgttcactgg ctcagcagtt     5580

atgtttacac atcattttta tgttcctgct ttgtaattca tgtttgagat gggtggccac     5640

tgtacagata tttattacgc tttccagact ttctgaatag atttttttga ataaacatgg     5700

ttttatgaag tgtaatcttt ttctagccta acaat                                5735


<210> 36
<211> 741
<212> PRT
<213> Homo sapiens

<400> 36
Met Pro Ile Ala Gln Leu Leu Glu Leu Trp Lys Lys Ile Glu Val Glu 
1               5                   10                  15      


Pro Met Glu Ile Glu Thr Thr Glu Glu Asp Leu Asn Leu Asp Val Glu 
            20                  25                  30          


Pro Thr Thr Glu Asp Thr Ala Glu Glu Glu Glu Gly Val Val Lys Glu 
        35                  40                  45              


Ile Asp Ile Ser His His Val Lys Glu Gly Phe Glu Lys Ala Asp Pro 
    50                  55                  60                  


Ser Gln Phe Glu Leu Leu Lys Val Leu Gly Gln Gly Ser Tyr Gly Lys 
65                  70                  75                  80  


Val Phe Leu Val Arg Lys Val Lys Gly Ser Asp Ala Gly Gln Leu Tyr 
                85                  90                  95      


Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val Arg Asp Arg Val 
            100                 105                 110         


Arg Ser Lys Met Glu Arg Asp Ile Leu Ala Glu Val Asn His Pro Phe 
        115                 120                 125             


Ile Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly Lys Leu Tyr Leu 
    130                 135                 140                 


Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr Arg Leu Ser Lys 
145                 150                 155                 160 


Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr Leu Ala Glu Leu 
                165                 170                 175     


Ala Leu Ala Leu Asp His Leu His Ser Leu Gly Ile Ile Tyr Arg Asp 
            180                 185                 190         


Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly His Ile Lys Ile 
        195                 200                 205             


Thr Asp Phe Gly Leu Ser Lys Glu Ala Ile Asp His Asp Lys Arg Ala 
    210                 215                 220                 


Tyr Ser Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu Val Val Asn 
225                 230                 235                 240 


Arg Arg Gly His Thr Gln Ser Ala Asp Trp Trp Ser Phe Gly Val Leu 
                245                 250                 255     


Met Phe Glu Met Leu Thr Gly Ser Leu Pro Phe Gln Gly Lys Asp Arg 
            260                 265                 270         


Lys Glu Thr Met Ala Leu Ile Leu Lys Ala Lys Leu Gly Met Pro Gln 
        275                 280                 285             


Phe Leu Ser Gly Glu Ala Gln Ser Leu Leu Arg Ala Leu Phe Lys Arg 
    290                 295                 300                 


Asn Pro Cys Asn Arg Leu Gly Ala Gly Ile Asp Gly Val Glu Glu Ile 
305                 310                 315                 320 


Lys Arg His Pro Phe Phe Val Thr Ile Asp Trp Asn Thr Leu Tyr Arg 
                325                 330                 335     


Lys Glu Ile Lys Pro Pro Phe Lys Pro Ala Val Gly Arg Pro Glu Asp 
            340                 345                 350         


Thr Phe His Phe Asp Pro Glu Phe Thr Ala Arg Thr Pro Thr Asp Ser 
        355                 360                 365             


Pro Gly Val Pro Pro Ser Ala Asn Ala His His Leu Phe Arg Gly Phe 
    370                 375                 380                 


Ser Phe Val Ala Ser Ser Leu Ile Gln Glu Pro Ser Gln Gln Asp Leu 
385                 390                 395                 400 


His Lys Val Pro Val His Pro Ile Val Gln Gln Leu His Gly Asn Asn 
                405                 410                 415     


Ile His Phe Thr Asp Gly Tyr Glu Ile Lys Glu Asp Ile Gly Val Gly 
            420                 425                 430         


Ser Tyr Ser Val Cys Lys Arg Cys Val His Lys Ala Thr Asp Thr Glu 
        435                 440                 445             


Tyr Ala Val Lys Ile Ile Asp Lys Ser Lys Arg Asp Pro Ser Glu Glu 
    450                 455                 460                 


Ile Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu 
465                 470                 475                 480 


Lys Asp Val Tyr Asp Asp Gly Lys Phe Val Tyr Leu Val Met Glu Leu 
                485                 490                 495     


Met Arg Gly Gly Glu Leu Leu Asp Arg Ile Leu Arg Gln Arg Tyr Phe 
            500                 505                 510         


Ser Glu Arg Glu Ala Ser Asp Val Leu Cys Thr Ile Thr Lys Thr Met 
        515                 520                 525             


Asp Tyr Leu His Ser Gln Gly Val Val His Arg Asp Leu Lys Pro Ser 
    530                 535                 540                 


Asn Ile Leu Tyr Arg Asp Glu Ser Gly Ser Pro Glu Ser Ile Arg Val 
545                 550                 555                 560 


Cys Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Gly Asn Gly Leu Leu 
                565                 570                 575     


Met Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys 
            580                 585                 590         


Arg Gln Gly Tyr Asp Ala Ala Cys Asp Ile Trp Ser Leu Gly Ile Leu 
        595                 600                 605             


Leu Tyr Thr Met Leu Ala Gly Phe Thr Pro Phe Ala Asn Gly Pro Asp 
    610                 615                 620                 


Asp Thr Pro Glu Glu Ile Leu Ala Arg Ile Gly Ser Gly Lys Tyr Ala 
625                 630                 635                 640 


Leu Ser Gly Gly Asn Trp Asp Ser Ile Ser Asp Ala Ala Lys Asp Val 
                645                 650                 655     


Val Ser Lys Met Leu His Val Asp Pro His Gln Arg Leu Thr Ala Met 
            660                 665                 670         


Gln Val Leu Lys His Pro Trp Val Val Asn Arg Glu Tyr Leu Ser Pro 
        675                 680                 685             


Asn Gln Leu Ser Arg Gln Asp Val His Leu Val Lys Gly Ala Met Ala 
    690                 695                 700                 


Ala Thr Tyr Phe Ala Leu Asn Arg Thr Pro Gln Ala Pro Arg Leu Glu 
705                 710                 715                 720 


Pro Val Leu Ser Ser Asn Leu Ala Gln Arg Arg Gly Met Lys Arg Leu 
                725                 730                 735     


Thr Ser Thr Arg Leu 
            740     


<210> 37
<211> 742
<212> PRT
<213> Homo sapiens

<400> 37
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 38
uauuccacgu ggagaaaaat t                                                 21


<210> 39
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 39
cgugggaugc ucaaagauat t                                                 21



