                         SEQUENCE LISTING

<110>  Van Anderl Research Institute
       Xu, Huaqiang Eric
       Ke, Jiyuan
 
<120>  Norrin Mutant Polypeptides, Methods of Making and Uses Thereof

<130>  232119-349809

<150>  US 61/767,569
<151>  2013-02-21

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(133)
<223>  Wild-type Human pre-cursor Norrin (133 a.a.)

<400>  1

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  X is any amino acid other than C and A

<400>  2

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Xaa His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  3
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  X is any amino acid other than C and A

<400>  3

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Xaa Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  4
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  X is any amino acid other than C and A

<400>  4

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Xaa Asn Ser 
    130             


<210>  5
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  X is any amino acid other than F  and  L

<400>  5

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Xaa Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  6
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  X is any amino acid other than I

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  X is any amino acid other than I

<400>  6

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Xaa Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  7
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  X is any amino acid other than R, K, T, and S

<400>  7

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Xaa His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  8
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  X is any amino acid other than H, R and Q

<400>  8

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His Xaa Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  9
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  X is any amino acid other than Y and C

<400>  9

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Xaa Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  10
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  X is any amino acid other than V, M and E

<400>  10

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Xaa Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  11
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  X is any amino acid other than H, R and Q

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  X is any amino acid other than Y and C

<400>  11

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His Xaa Xaa Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  12
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  X is any amino acid other than H, R and Q

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  X is any amino acid other than V, M and E

<400>  12

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His Xaa Tyr Xaa Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  13
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  X is any amino acid other than Y and C

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  X is any amino acid other than V, M and E

<400>  13

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Xaa Xaa Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  14
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  X is any amino acid other than H, R and Q

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  X is any amino acid other than Y and C

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  X is any amino acid other than V, M and E

<400>  14

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His Xaa Xaa Xaa Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  15
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  X is any amino acid other than M

<400>  15

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Xaa Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  16
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  X is any amino acid other than V and E

<400>  16

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Xaa Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  17
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  X is any amino acid other than L, F, I and P

<400>  17

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Xaa Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  18
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  X is any amino acid other than M

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  X is any amino acid other than V and E

<400>  18

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Xaa Xaa Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  19
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  X is any amino acid other than M

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  X is any amino acid other than L, F, I and P

<400>  19

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Xaa Val Xaa Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  20
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  X is any amino acid other than V and E

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  X is any amino acid other than L, F, I and P

<400>  20

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Xaa Xaa Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  21
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  X is any amino acid other than Y and C

<400>  21

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Xaa Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  22
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  X is any amino acid other than R, G, W, Q and L

<400>  22

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Xaa Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  23
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  X is any amino acid other than Y

<400>  23

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Xaa Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  24
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  X is any amino acid other than Y and C

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  X is any amino acid other than R, G, W, Q and L

<400>  24

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Xaa Xaa Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  25
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  X is any amino acid other than Y and C

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  X is any amino acid other than Y

<400>  25

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Xaa Arg Xaa Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  26
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  X is any amino acid other than R, G, W, Q and L

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  X is any amino acid other than Y

<400>  26

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Xaa Xaa Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  27
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  X is any amino acid other than L

<400>  27

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Xaa Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  28
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X is any amino acid other than Y

<400>  28

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Xaa Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  29
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  X is any amino acid other than K and N

<400>  29

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Xaa Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  30
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  X is any amino acid other than L

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X is any amino acid other than Y

<400>  30

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Xaa Xaa Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  31
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  X is any amino acid other than L

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  X is any amino acid other than K and N

<400>  31

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Xaa Tyr Xaa Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  32
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X is any amino acid other than Y

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  X is any amino acid other than K and N

<400>  32

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Xaa Xaa Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  33
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  X is any amino acid other than R

<400>  33

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Xaa Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  34
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  X is any amino acid other than R

<400>  34

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Xaa Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  35
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  X is any amino acid other than R and L

<400>  35

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Xaa Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  36
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  X is any amino acid other than R

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  X is any amino acid other than R and L

<400>  36

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Xaa Cys Ser Gly 
            100                 105                 110         


Gly Met Xaa Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  37
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  X is any amino acid other than K and N

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  X is any amino acid other than R

<400>  37

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Xaa Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Xaa Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  38
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  X is any amino acid other than C, R, and F

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  X is any amino acid other than C, R, G, and S

<400>  38

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Xaa Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Xaa Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  39
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(327)
<223>  Mature Human Norrin DNA sequence of SEQ ID NO:41

<400>  39
aaaacggaca gctcattcat aatggactcg gaccctcgac gctgcatgag gcaccactat       60

gtggattcta tcagtcaccc attgtacaag tgtagctcaa agatggtgct cctggccagg      120

tgcgaggggc actgcagcca ggcgtcacgc tccgagcctt tggtgtcgtt cagcactgtc      180

ctcaagcaac ccttccgttc ctcctgtcac tgctgccggc cccagacttc caagctgaag      240

gcactgcggc tgcgatgctc agggggcatg cgactcactg ccacctaccg gtacatcctc      300

tcctgtcact gcgaggaatg caattcc                                          327


<210>  40
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant MBP-Norrin protein sequence

<400>  40

Met Ala Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp 
1               5                   10                  15      


Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp 
            20                  25                  30          


Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys 
        35                  40                  45              


Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp 
    50                  55                  60                  


Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu 
65                  70                  75                  80  


Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp 
                85                  90                  95      


Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val 
            100                 105                 110         


Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro 
        115                 120                 125             


Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys 
    130                 135                 140                 


Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp 
145                 150                 155                 160 


Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly 
                165                 170                 175     


Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala 
            180                 185                 190         


Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala 
        195                 200                 205             


Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr 
    210                 215                 220                 


Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser 
225                 230                 235                 240 


Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro 
                245                 250                 255     


Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser 
            260                 265                 270         


Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr 
        275                 280                 285             


Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val 
    290                 295                 300                 


Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala 
305                 310                 315                 320 


Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro 
                325                 330                 335     


Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala 
            340                 345                 350         


Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
        355                 360                 365             


Asn Ala Ala Ala Glu Phe Lys Thr Asp Ser Ser Phe Ile Met Asp Ser 
    370                 375                 380                 


Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile Ser His 
385                 390                 395                 400 


Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg Cys Glu 
                405                 410                 415     


Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser Phe Ser 
            420                 425                 430         


Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys Arg Pro 
        435                 440                 445             


Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly Gly Met 
    450                 455                 460                 


Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys Glu Glu 
465                 470                 475                 480 


Cys Asn Ser 
            


<210>  41
<211>  109
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(109)
<223>  Mature Human Norrin protein sequence

<400>  41

Lys Thr Asp Ser Ser Phe Ile Met Asp Ser Asp Pro Arg Arg Cys Met 
1               5                   10                  15      


Arg His His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly His Cys Ser Gln Ala 
        35                  40                  45              


Ser Arg Ser Glu Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Arg Ser Ser Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Leu Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Asn Ser 
            100                 105                 


<210>  42
<211>  374
<212>  PRT
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (1)..(374)
<223>  MBP protein sequence

<400>  42

Met Ala Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp 
1               5                   10                  15      


Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp 
            20                  25                  30          


Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys 
        35                  40                  45              


Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp 
    50                  55                  60                  


Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu 
65                  70                  75                  80  


Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp 
                85                  90                  95      


Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val 
            100                 105                 110         


Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro 
        115                 120                 125             


Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys 
    130                 135                 140                 


Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp 
145                 150                 155                 160 


Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly 
                165                 170                 175     


Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala 
            180                 185                 190         


Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala 
        195                 200                 205             


Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr 
    210                 215                 220                 


Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser 
225                 230                 235                 240 


Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro 
                245                 250                 255     


Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser 
            260                 265                 270         


Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr 
        275                 280                 285             


Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val 
    290                 295                 300                 


Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala 
305                 310                 315                 320 


Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro 
                325                 330                 335     


Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala 
            340                 345                 350         


Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
        355                 360                 365             


Asn Ala Ala Ala Glu Phe 
    370                 


<210>  43
<211>  1452
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1452)
<223>  MBP-Human Norrin fusion DNA sequence

<400>  43
atggcaaaaa tcgaagaagg taaactggta atctggatta acggcgataa aggctataac       60

ggtctcgctg aagtcggtaa gaaattcgag aaagataccg gaattaaagt caccgttgag      120

catccggata aactggaaga gaaattccca caggttgcgg caactggcga tggccctgac      180

attatcttct gggcacacga ccgctttggt ggctacgctc aatctggcct gttggctgaa      240

atcaccccgg acaaagcgtt ccaggacaag ctgtatccgt ttacctggga tgccgtacgt      300

tacaacggca agctgattgc ttacccgatc gctgttgaag cgttatcgct gatttataac      360

aaagatctgc tgccgaaccc gccaaaaacc tgggaagaga tcccggcgct ggataaagaa      420

ctgaaagcga aaggtaagag cgcgctgatg ttcaacctgc aagaaccgta cttcacctgg      480

ccgctgattg ctgctgacgg gggttatgcg ttcaagtatg aaaacggcaa gtacgacatt      540

aaagacgtgg gcgtggataa cgctggcgcg aaagcgggtc tgaccttcct ggttgacctg      600

attaaaaaca aacacatgaa tgcagacacc gattactcca tcgcagaagc tgcctttaat      660

aaaggcgaaa cagcgatgac catcaacggc ccgtgggcat ggtccaacat cgacaccagc      720

aaagtgaatt atggtgtaac ggtactgccg accttcaagg gtcaaccatc caaaccgttc      780

gttggcgtgc tgagcgcagg tattaacgcc gccagtccga acaaagagct ggcgaaagag      840

ttcctcgaaa actatctgct gactgatgaa ggtctggaag cggttaataa agacaaaccg      900

ctgggtgccg tagcgctgaa gtcttacgag gaagagttgg cgaaagatcc acgtattgcc      960

gccactatgg aaaacgccca gaaaggtgaa atcatgccga acatcccgca gatgtccgct     1020

ttctggtatg ccgtgcgtac tgcggtgatc aacgccgcca gcggtcgtca gactgtcgat     1080

gaagccctga aagacgcgca gactaacgcg gcggccgaat tcaaaacgga cagctcattc     1140

ataatggact cggaccctcg acgctgcatg aggcaccact atgtggattc tatcagtcac     1200

ccattgtaca agtgtagctc aaagatggtg ctcctggcca ggtgcgaggg gcactgcagc     1260

caggcgtcac gctccgagcc tttggtgtcg ttcagcactg tcctcaagca acccttccgt     1320

tcctcctgtc actgctgccg gccccagact tccaagctga aggcactgcg gctgcgatgc     1380

tcagggggca tgcgactcac tgccacctac cggtacatcc tctcctgtca ctgcgaggaa     1440

tgcaattcct ga                                                         1452


<210>  44
<211>  1122
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1122)
<223>  MBP-DNA sequence

<400>  44
atggcaaaaa tcgaagaagg taaactggta atctggatta acggcgataa aggctataac       60

ggtctcgctg aagtcggtaa gaaattcgag aaagataccg gaattaaagt caccgttgag      120

catccggata aactggaaga gaaattccca caggttgcgg caactggcga tggccctgac      180

attatcttct gggcacacga ccgctttggt ggctacgctc aatctggcct gttggctgaa      240

atcaccccgg acaaagcgtt ccaggacaag ctgtatccgt ttacctggga tgccgtacgt      300

tacaacggca agctgattgc ttacccgatc gctgttgaag cgttatcgct gatttataac      360

aaagatctgc tgccgaaccc gccaaaaacc tgggaagaga tcccggcgct ggataaagaa      420

ctgaaagcga aaggtaagag cgcgctgatg ttcaacctgc aagaaccgta cttcacctgg      480

ccgctgattg ctgctgacgg gggttatgcg ttcaagtatg aaaacggcaa gtacgacatt      540

aaagacgtgg gcgtggataa cgctggcgcg aaagcgggtc tgaccttcct ggttgacctg      600

attaaaaaca aacacatgaa tgcagacacc gattactcca tcgcagaagc tgcctttaat      660

aaaggcgaaa cagcgatgac catcaacggc ccgtgggcat ggtccaacat cgacaccagc      720

aaagtgaatt atggtgtaac ggtactgccg accttcaagg gtcaaccatc caaaccgttc      780

gttggcgtgc tgagcgcagg tattaacgcc gccagtccga acaaagagct ggcgaaagag      840

ttcctcgaaa actatctgct gactgatgaa ggtctggaag cggttaataa agacaaaccg      900

ctgggtgccg tagcgctgaa gtcttacgag gaagagttgg cgaaagatcc acgtattgcc      960

gccactatgg aaaacgccca gaaaggtgaa atcatgccga acatcccgca gatgtccgct     1020

ttctggtatg ccgtgcgtac tgcggtgatc aacgccgcca gcggtcgtca gactgtcgat     1080

gaagccctga aagacgcgca gactaacgcg gcggccgaat tc                        1122


<210>  45
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  45

Lys Thr Asp Ser Ser Phe Ile Met Asp Ser Asp Pro Arg Arg Cys Met 
1               5                   10                  15      


Arg His His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly His Cys Ser Gln Ala 
        35                  40                  45              


Ser Arg Ser Glu Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Arg Ser Ser Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Leu Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Asn Ser 
            100                 105                 


<210>  46
<211>  109
<212>  PRT
<213>  Canis lupus

<400>  46

Lys Thr Asp Ser Ser Phe Met Met Asp Ser Asp Pro Leu Arg Cys Met 
1               5                   10                  15      


Arg His His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly His Cys Ser Gln Ala 
        35                  40                  45              


Ser Arg Ser Glu Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Arg Ser Ser Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Leu Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Ser Ser 
            100                 105                 


<210>  47
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  47

Lys Thr Asp Ser Ser Phe Leu Met Asp Ser Gln Arg Cys Met Arg His 
1               5                   10                  15      


His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser Ser Lys 
            20                  25                  30          


Met Val Leu Leu Ala Arg Cys Glu Gly His Cys Ser Gln Ala Ser Arg 
        35                  40                  45              


Ser Glu Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro Phe Arg 
    50                  55                  60                  


Ser Ser Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu 
65                  70                  75                  80  


Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr 
                85                  90                  95      


Ile Leu Ser Cys His Cys Glu Glu Cys Ser Ser 
            100                 105         


<210>  48
<211>  109
<212>  PRT
<213>  Monodelphis domestica

<400>  48

Lys Met Asp Ser Ala Phe Leu Met Asp Ser Asp Pro Gly Arg Cys Met 
1               5                   10                  15      


Arg His His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly His Cys Ser Gln Pro 
        35                  40                  45              


Ser Arg Ser Glu Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Arg Ser Thr Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Leu Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Ser Ser 
            100                 105                 


<210>  49
<211>  109
<212>  PRT
<213>  Gallus gallus

<400>  49

Lys Pro Asp Ser Ser Phe Met Ile Asp Asn Asp Pro Ser Arg Cys Met 
1               5                   10                  15      


Arg His His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly Arg Cys Ser Gln Thr 
        35                  40                  45              


Ser Arg Ser Glu Pro Met Val Ser Phe Ser Thr Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Arg Ser Thr Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Met Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Asn Ser 
            100                 105                 


<210>  50
<211>  109
<212>  PRT
<213>  Taeniopygia guttata

<400>  50

Lys Thr Glu Gly Ser Phe Leu Met Asp Ser Asp Pro Ser Arg Cys Met 
1               5                   10                  15      


Arg His His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly Arg Cys Ser Gln Thr 
        35                  40                  45              


Ser Arg Ser Glu Pro Met Val Ser Phe Ser Thr Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Arg Ser Thr Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Met Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Asn Ser 
            100                 105                 


<210>  51
<211>  110
<212>  PRT
<213>  Xenopus laevis

<400>  51

Asp Lys Lys Gly Lys Ala Phe Leu Ala Glu Ser Asp Pro Asp Arg Cys 
1               5                   10                  15      


Met Arg His His Tyr Val Asp Ser Ile Asn His Pro Gln His Lys Cys 
            20                  25                  30          


Thr Ala Lys Met Val Leu Leu Ala Arg Cys Glu Gly Arg Cys Ser Gln 
        35                  40                  45              


Thr Ser Arg Ser Asp Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln 
    50                  55                  60                  


Pro Phe Arg Ser Thr Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu 
65                  70                  75                  80  


Lys Ala Ile Arg Leu Arg Cys Ser Gly Gly Arg Arg Met Thr Ala Thr 
                85                  90                  95      


Tyr Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Asn Ser 
            100                 105                 110 


<210>  52
<211>  108
<212>  PRT
<213>  Danio rerio

<400>  52

Lys Ala Glu Ser Gly His Leu Gly Asp Asn Asp Pro Asp Arg Cys Met 
1               5                   10                  15      


Arg His His Phe Val Glu Thr Ile Thr His Pro Ile Tyr Lys Cys Asn 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly His Cys Ser His Thr 
        35                  40                  45              


Ser Arg Ser Asp Pro Leu Ile Ser Phe Ser Ser Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Lys Asn Thr Cys Phe Cys Cys Arg Pro His Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Val Arg Leu Arg Cys Ser Gly Gly Thr Arg Ile Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ala Cys Ser Cys Glu Glu Cys Ser 
            100                 105             


<210>  53
<211>  109
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  53

Lys Met Asp Arg Thr Val Arg Thr Asp Ala Asp Pro Gly Gln Cys Met 
1               5                   10                  15      


Arg His His Tyr Val Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser 
            20                  25                  30          


Ser Lys Met Val Leu Leu Ala Arg Cys Glu Gly Arg Cys Ser Gln Ser 
        35                  40                  45              


Ser Arg Ser Glu Pro Leu Val Ser Phe Ser Ala Val Leu Lys Gln Pro 
    50                  55                  60                  


Phe Arg Ser Thr Cys Tyr Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys 
65                  70                  75                  80  


Ala Leu Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr 
                85                  90                  95      


Arg Tyr Ile Leu Ser Cys His Cys Glu Gln Cys Ser Ser 
            100                 105                 


<210>  54
<211>  104
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(104)
<223>  von Willebrand factor

<400>  54

Lys Ile Pro Gly Thr Cys Cys Asp Thr Cys Glu Glu Pro Glu Cys Asn 
1               5                   10                  15      


Asp Ile Thr Ala Arg Leu Gln Tyr Val Lys Val Gly Ser Cys Lys Ser 
            20                  25                  30          


Glu Val Glu Val Asp Ile His Tyr Cys Gln Gly Lys Cys Ala Ser Lys 
        35                  40                  45              


Ala Met Tyr Ser Ile Asp Ile Asn Asp Val Gln Asp Gln Cys Ser Cys 
    50                  55                  60                  


Cys Ser Pro Thr Arg Thr Glu Pro Met Gln Val Ala Leu His Cys Thr 
65                  70                  75                  80  


Asn Gly Ser Val Val Tyr His Glu Val Leu Asn Ala Met Glu Cys Lys 
                85                  90                  95      


Cys Ser Pro Arg Lys Cys Ser Lys 
            100                 


<210>  55
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(102)
<223>  Mucin2

<400>  55

Cys Cys Lys Thr Cys Thr Pro Arg Asn Glu Thr Arg Val Pro Cys Ser 
1               5                   10                  15      


Thr Val Pro Val Thr Thr Glu Val Ser Tyr Ala Gly Cys Thr Lys Thr 
            20                  25                  30          


Val Leu Met Asn His Cys Ser Gly Ser Cys Gly Thr Phe Val Met Tyr 
        35                  40                  45              


Ser Ala Lys Ala Gln Ala Leu Asp His Ser Cys Ser Cys Cys Lys Glu 
    50                  55                  60                  


Glu Lys Thr Ser Gln Arg Glu Val Val Leu Ser Cys Pro Asn Gly Gly 
65                  70                  75                  80  


Ser Leu Thr His Thr Tyr Thr His Ile Glu Ser Cys Gln Cys Gln Asp 
                85                  90                  95      


Thr Val Cys Gly Leu Pro 
            100         


<210>  56
<211>  97
<212>  PRT
<213>  Sus scrofa


<220>
<221>  misc_feature
<222>  (1)..(97)
<223>  Mucin-pig

<400>  56

Cys Cys Tyr Thr Cys Lys Ser Ser Cys Lys Pro Ser Pro Val Asn Val 
1               5                   10                  15      


Thr Val Arg Tyr Asn Gly Cys Thr Ile Lys Val Glu Met Ala Arg Cys 
            20                  25                  30          


Val Gly Glu Cys Lys Lys Thr Val Thr Tyr Asp Tyr Asp Ile Phe Gln 
        35                  40                  45              


Leu Lys Asn Ser Cys Leu Cys Cys Gln Glu Glu Asp Tyr Glu Glu Arg 
    50                  55                  60                  


Asp Ile Val Leu Asp Cys Pro Asp Gly Ser Thr Leu Leu Pro Tyr Arg 
65                  70                  75                  80  


Tyr Arg His Ile Thr Ala Cys Ser Cys Leu Asp Asp Pro Cys Gln Gln 
                85                  90                  95      


Ser 
    


<210>  57
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(112)
<223>  TGF-beta1

<400>  57

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  58
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(112)
<223>  TGF-beta3

<400>  58

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  59
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(112)
<223>  TGF-beta2

<400>  59

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  60
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  X is any other amino acid other than C, R, and F

<400>  60

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Xaa Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  61
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  X is any other amino acid other than C, W, and Y

<400>  61

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Xaa Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  62
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  X is any other amino acid other than C, R, G, and S

<400>  62

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Xaa Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


