                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  Bispecific T cell activating antigen binding molecules

<130>  31447

<150>  EP 13156686.1
<151>  2013-02-26

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CD3 CH2527 (VH_3-23(12))

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  2
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527 (VL_7-46(13))

<400>  2

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  3
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CD3 CH2527 (VH_3-23(12))

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 CD3 CH2527 (VH_3-23(12))

<400>  4

Thr Tyr Ala Met Asn 
1               5   


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 CD3 CH2527 (VH_3-23(12))

<400>  5

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 CD3 CH2527 (VH_3-23(12))

<400>  6

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  7
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CD3 CH2527 (VL_7-46(13))

<400>  7

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 CD3 CH2527 (VL_7-46(13))

<400>  8

Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 CD3 CH2527 (VL_7-46(13))

<400>  9

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 CD3 CH2527 (VL_7-46(13))

<400>  10

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  11
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC MCSP M4-3 (C1)$

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Phe Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  12
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC MCSP ML2 (G3)

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH MCSP M4-3 (C1)

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Phe Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 MCSP M4-3 (C1)

<400>  14

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 MCSP M4-3 (C1)

<400>  15

Tyr Ile Thr Phe Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 MCSP M4-3 (C1)

<400>  16

Phe Asp Tyr 
1           


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL MCSP ML2 (G3)

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 MCSP ML2 (G3)

<400>  18

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 MCSP ML2 (G3)

<400>  19

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 MCSP ML2 (G3)

<400>  20

Gln Gln Tyr Ser Ala Leu Pro Trp Thr 
1               5                   


<210>  21
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CEA CH1A1A 98-99

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  22
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CEA 2F1

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  23
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CEA CH1A1A 98-99

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 CEA CH1A1A 98-99

<400>  24

Glu Phe Gly Met Asn 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 CEA CH1A1A 98-99

<400>  25

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 CEA CH1A1A 98-99

<400>  26

Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  27
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CEA 2F1

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 CEA 2F1

<400>  28

Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 CEA 2F1

<400>  29

Ser Ala Ser Tyr Arg Lys Arg 
1               5           


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 CEA 2F1

<400>  30

His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr 
1               5                   10  


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CD3 CH2527 (VL_7-43(11))

<400>  31

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser 
            100                 105                 110     


<210>  32
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CD3 CH2527 (VHcomboA49SV93A)

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CD3 CH2527 (VHcomboA49SV93AR94K)

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH MCSP M4-3 (D6)

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Phe Asp Gly Lys Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 MCSP M4-3 (D6)

<400>  35

Ile Thr Phe Asp Gly Lys Asn Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15  


<210>  36
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH MCSP M4-3 (A7)

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Asp Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Phe Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 MCSP M4-3 (A7)

<400>  37

Asp Gly Tyr Tyr Trp Asn 
1               5       


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 MCSP M4-3 (A7)

<400>  38

Ile Thr Phe Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15  


<210>  39
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH MCSP M4-3 (B7)

<400>  39

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Phe Asp Gly Ile Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 MCSP M4-3 (B7)

<400>  40

Ile Thr Phe Asp Gly Ile Asn Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15  


<210>  41
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH MCSP M4-3 (B8)

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Phe Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH MCSP M4-3

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  43
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL MCSP ML2 (E10)

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Tyr Gly Ile Arg Gly Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr His Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 MCSP ML2 (E10)

<400>  44

Arg Ala Ser Tyr Gly Ile Arg Gly Tyr Leu Asn 
1               5                   10      


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 MCSP ML2 (E10)

<400>  45

Gln Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL MCSP ML2 (E10-G3)

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Tyr Gly Ile Arg Gly Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr His Cys Gln Gln Tyr Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL MCSP ML2 (C5)

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Gly Ile Arg Glu Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Gly Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 MCSP ML2 (C5)

<400>  48

Arg Ala Ser Arg Gly Ile Arg Glu Tyr Leu Asn 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 MCSP ML2 (C5)

<400>  49

Tyr Thr Gly Ser Leu His Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 MCSP ML2 (C5)

<400>  50

Gln Gln Tyr Ser Glu Leu Pro Trp Thr 
1               5                   


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL MCSP ML2 (C5-G3)

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Gly Ile Arg Glu Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Gly Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  52
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL MCSP ML2

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  53
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527  (Crossfab, VL-CH1)

<400>  53

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Val Glu Pro Lys Ser Cys 
    210                 


<210>  54
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCSP M4-3 (C1) (VH-CH1) - CD3 CH2527 (Crossfab VH-Ck) - Fc(knob) 
       P329GLALA

<400>  54

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Phe Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
225                 230                 235                 240 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                245                 250                 255     


Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            260                 265                 270         


Trp Val Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
        275                 280                 285             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
    290                 295                 300                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
305                 310                 315                 320 


Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser 
                325                 330                 335     


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            340                 345                 350         


Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        355                 360                 365             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    370                 375                 380                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
385                 390                 395                 400 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                405                 410                 415     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            420                 425                 430         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        435                 440                 445             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys 
    450                 455                 460                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
465                 470                 475                 480 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                485                 490                 495     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            500                 505                 510         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        515                 520                 525             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    530                 535                 540                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
545                 550                 555                 560 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                565                 570                 575     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            580                 585                 590         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        595                 600                 605             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    610                 615                 620                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
625                 630                 635                 640 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                645                 650                 655     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            660                 665                 670         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680                 685 


<210>  55
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCSP M4-3 (C1) (VH-CH1) - Fc(hole) P329GLALA

<400>  55

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Phe Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  56
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527 (Crossfab, VL-CH1)

<400>  56

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Val Glu Pro Lys Ser Cys 
    210                 


<210>  57
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CH1A1A 98/99 - CD3 CH2527 (Crossfab VH-Ck) - Fc(knob) 
       P329GLALA

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                245                 250                 255     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Ala Met Asn Trp Val 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile Arg Ser 
        275                 280                 285             


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    290                 295                 300                 


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met 
305                 310                 315                 320 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
                325                 330                 335     


Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln 
            340                 345                 350         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val 
        355                 360                 365             


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
    370                 375                 380                 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
385                 390                 395                 400 


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
                405                 410                 415     


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
            420                 425                 430         


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
        435                 440                 445             


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
    450                 455                 460                 


Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
465                 470                 475                 480 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                485                 490                 495     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            500                 505                 510         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        515                 520                 525             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    530                 535                 540                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
545                 550                 555                 560 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
                565                 570                 575     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            580                 585                 590         


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
        595                 600                 605             


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    610                 615                 620                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
625                 630                 635                 640 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                645                 650                 655     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            660                 665                 670         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        675                 680                 685             


Ser Leu Ser Pro Gly Lys 
    690                 


<210>  58
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CH1A1A 98/99 (VH-CH1) - Fc(hole) P329GLALA

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  59
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC DP47 GS

<400>  59

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  60
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527 (Crossfab, VL-CH1)

<400>  60

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Val Glu Pro Lys Ser Cys 
    210                 


<210>  61
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DP47 GS (VH-CH1) - CD3 CH2527 (Crossfab VH-Ck) - Fc(knob) 
       P329GLALA

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
225                 230                 235                 240 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                245                 250                 255     


Thr Phe Ser Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            260                 265                 270         


Gly Leu Glu Trp Val Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
        275                 280                 285             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    290                 295                 300                 


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
305                 310                 315                 320 


Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
                325                 330                 335     


Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            340                 345                 350         


Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        355                 360                 365             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    370                 375                 380                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
385                 390                 395                 400 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                405                 410                 415     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            420                 425                 430         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        435                 440                 445             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr 
    450                 455                 460                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
465                 470                 475                 480 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                485                 490                 495     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            500                 505                 510         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        515                 520                 525             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    530                 535                 540                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
545                 550                 555                 560 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                565                 570                 575     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            580                 585                 590         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        595                 600                 605             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    610                 615                 620                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
625                 630                 635                 640 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                645                 650                 655     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            660                 665                 670         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680                 685             


<210>  62
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DP47 GS (VH-CH1) - Fc(hole) P329GLALA

<400>  62

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  63
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC CD3 CH2527 (VH_3-23(12))

<400>  63
gaggtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc acctacgcca tgaactgggt gcgccaggcc      120

cctggcaaag gcctggaatg ggtgtcccgg atcagaagca agtacaacaa ctacgccacc      180

tactacgccg acagcgtgaa gggccggttc accatcagcc gggacgacag caagaacacc      240

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtacta ttgtgtgcgg      300

cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcaccctc      360

gtgaccgtgt catctgctag caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1365


<210>  64
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527 (VL_7-46(13))

<400>  64
caggccgtcg tgacccagga acccagcctg acagtgtctc ctggcggcac cgtgaccctg       60

acatgtggca gttctacagg cgccgtgacc accagcaact acgccaactg ggtgcaggaa      120

aagcccggcc aggccttcag aggactgatc ggcggcacca acaagagagc ccctggcacc      180

cctgccagat tcagcggatc tctgctggga ggaaaggccg ccctgacact gtctggcgcc      240

cagccagaag atgaggccga gtactactgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggca ccaagctgac agtcctaggt caacccaagg ctgcccccag cgtgaccctg      360

ttccccccca gcagcgagga actgcaggcc aacaaggcca ccctggtctg cctgatcagc      420

gacttctacc caggcgccgt gaccgtggcc tggaaggccg acagcagccc cgtgaaggcc      480

ggcgtggaga ccaccacccc cagcaagcag agcaacaaca agtacgccgc cagcagctac      540

ctgagcctga cccccgagca gtggaagagc cacaggtcct acagctgcca ggtgacccac      600

gagggcagca ccgtggagaa aaccgtggcc cccaccgagt gcagc                      645


<210>  65
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH CD3 CH2527 (VH_3-23(12))

<400>  65
gaggtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc acctacgcca tgaactgggt gcgccaggcc      120

cctggcaaag gcctggaatg ggtgtcccgg atcagaagca agtacaacaa ctacgccacc      180

tactacgccg acagcgtgaa gggccggttc accatcagcc gggacgacag caagaacacc      240

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtacta ttgtgtgcgg      300

cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcaccctc      360

gtgaccgtgt catct                                                       375


<210>  66
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 CD3 CH2527 (VH_3-23(12))

<400>  66
acctacgcca tgaac                                                        15


<210>  67
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 CD3 CH2527 (VH_3-23(12))

<400>  67
cggatcagaa gcaagtacaa caactacgcc acctactacg ccgacagcgt gaagggc          57


<210>  68
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 CD3 CH2527 (VH_3-23(12))

<400>  68
cacggcaact tcggcaacag ctatgtgtct tggtttgcct ac                          42


<210>  69
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL CD3 CH2527 (VL_7-46(13))

<400>  69
caggccgtcg tgacccagga acccagcctg acagtgtctc ctggcggcac cgtgaccctg       60

acatgtggca gttctacagg cgccgtgacc accagcaact acgccaactg ggtgcaggaa      120

aagcccggcc aggccttcag aggactgatc ggcggcacca acaagagagc ccctggcacc      180

cctgccagat tcagcggatc tctgctggga ggaaaggccg ccctgacact gtctggcgcc      240

cagccagaag atgaggccga gtactactgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggca ccaagctgac agtccta                                          327


<210>  70
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 CD3 CH2527 (VL_7-46(13))

<400>  70
ggcagttcta caggcgccgt gaccaccagc aactacgcca ac                          42


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 CD3 CH2527 (VL_7-46(13))

<400>  71
ggcaccaaca agagagcccc t                                                 21


<210>  72
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 CD3 CH2527 (VL_7-46(13))

<400>  72
gccctgtggt acagcaacct gtgggtg                                           27


<210>  73
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC MCSP M4-3 (C1)

<400>  73
caggtgcaat tgcaggaaag cggccctggc ctggtcaagc ccagccagac cctgagcctg       60

acctgcaccg tgtccggcgg cagcatcacc agcggctatt attggaactg gattcggcag      120

caccccggca agggcctgga atggatcggc tacatcactt tcgacggctc taacaactac      180

aaccccagcc tgaagtccag agtgaccatc agccgggaca ccagcaagaa ccagttcagc      240

ctgaagctgt ccagcgtgac agccgccgac accgccgtgt actactgcgc cgacttcgac      300

tactggggcc agggcaccct ggtcaccgtg tccagcgcta gcaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaa                                                                1326


<210>  74
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC MCSP ML2 (G3)

<400>  74
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgcc gggccagcca gggcatccgg aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagcc tgcacagcgg cgtgcctagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccattagctc cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tactctgctc tgccgtggac cttcggccag      300

ggaacaaagg tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  75
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH MCSP M4-3 (C1)

<400>  75
caggtgcaat tgcaggaaag cggccctggc ctggtcaagc ccagccagac cctgagcctg       60

acctgcaccg tgtccggcgg cagcatcacc agcggctatt attggaactg gattcggcag      120

caccccggca agggcctgga atggatcggc tacatcactt tcgacggctc taacaactac      180

aaccccagcc tgaagtccag agtgaccatc agccgggaca ccagcaagaa ccagttcagc      240

ctgaagctgt ccagcgtgac agccgccgac accgccgtgt actactgcgc cgacttcgac      300

tactggggcc agggcaccct ggtcaccgtg tccagc                                336


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 MCSP M4-3 (C1)

<400>  76
agcggctatt attggaac                                                     18


<210>  77
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 MCSP M4-3 (C1)

<400>  77
tacatcactt tcgacggctc taacaactac aaccccagcc tgaagtcc                    48


<210>  78
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 MCSP M4-3 (C1)

<400>  78
ttcgactac                                                                9


<210>  79
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL MCSP ML2 (G3)

<400>  79
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgcc gggccagcca gggcatccgg aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagcc tgcacagcgg cgtgcctagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccattagctc cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tactctgctc tgccgtggac cttcggccag      300

ggaacaaagg tggagatcaa g                                                321


<210>  80
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 MCSP ML2 (G3)

<400>  80
cgggccagcc agggcatccg gaactacctg aac                                    33


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 MCSP ML2 (G3)

<400>  81
tacaccagca gcctgcacag c                                                 21


<210>  82
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 MCSP ML2 (G3)

<400>  82
cagcagtact ctgctctgcc gtggacc                                           27


<210>  83
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC CEA CH1A1A 98-99

<400>  83
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agcgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  84
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC CEA 2F1

<400>  84
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  85
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH CEA CH1A1A 98-99

<400>  85
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  86
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 CEA CH1A1A 98-99

<400>  86
gagttcggca tgaac                                                        15


<210>  87
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 CEA CH1A1A 98-99

<400>  87
tggatcaaca ccaagaccgg cgaggccacc tacgtggaag agttcaaggg c                51


<210>  88
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 CEA CH1A1A 98-99

<400>  88
tgggacttcg cctattacgt ggaagccatg gactac                                 36


<210>  89
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL CEA 2F1

<400>  89
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caag                                             324


<210>  90
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 CEA 2F1

<400>  90
aaggccagtg cggctgtggg tacgtatgtt gcg                                    33


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 CEA 2F1

<400>  91
tcggcatcct accgcaaaag g                                                 21


<210>  92
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 CEA 2F1

<400>  92
caccaatatt acacctatcc tctattcacg                                        30


<210>  93
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527 (Crossfab, VL-CH1)

<400>  93
caggccgtcg tgacccagga acccagcctg acagtgtctc ctggcggcac cgtgaccctg       60

acatgtggca gttctacagg cgccgtgacc accagcaact acgccaactg ggtgcaggaa      120

aagcccggcc aggccttcag aggactgatc ggcggcacca acaagagagc ccctggcacc      180

cctgccagat tcagcggatc tctgctggga ggaaaggccg ccctgacact gtctggcgcc      240

cagccagaag atgaggccga gtactactgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggca ccaagctgac agtgctgagc agcgcttcca ccaaaggccc ttccgtgttt      360

cctctggctc ctagctccaa gtccacctct ggaggcaccg ctgctctcgg atgcctcgtg      420

aaggattatt ttcctgagcc tgtgacagtg tcctggaata gcggagcact gacctctgga      480

gtgcatactt tccccgctgt gctgcagtcc tctggactgt acagcctgag cagcgtggtg      540

acagtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      600

agcaacacca aggtggacaa gaaggtggaa cccaagtctt gt                         642


<210>  94
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCSP M4-3 (C1) (VH-CH1) - CD3 CH2527 (Crossfab VH-Ck) - Fc(knob) 
       P329GLALA

<400>  94
caggtgcaat tgcaggaaag cggccctggc ctggtcaagc ccagccagac cctgagcctg       60

acctgcaccg tgtccggcgg cagcatcacc agcggctatt attggaactg gattcggcag      120

caccccggca agggcctgga atggatcggc tacatcactt tcgacggctc taacaactac      180

aaccccagcc tgaagtccag agtgaccatc agccgggaca ccagcaagaa ccagttcagc      240

ctgaagctgt ccagcgtgac agccgccgac accgccgtgt actactgcgc cgacttcgac      300

tactggggcc agggcaccct ggtcaccgtg tccagcgcta gcacaaaggg ccccagcgtg      360

ttccctctgg cccctagcag caagagcaca tctggcggaa cagccgccct gggctgcctc      420

gtgaaggact actttcccga gcctgtgacc gtgtcctgga actctggcgc cctgacaagc      480

ggcgtgcaca cctttccagc cgtgctgcag agcagcggcc tgtactctct gagcagcgtg      540

gtcaccgtgc ctagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      600

cccagcaaca ccaaagtgga caagaaggtg gagcccaaga gctgtgatgg cggaggaggg      660

tccggaggcg gaggatccga ggtgcagctg ctggaatctg gcggcggact ggtgcagcct      720

ggcggatctc tgagactgag ctgtgccgcc agcggcttca ccttcagcac ctacgccatg      780

aactgggtgc gccaggcccc tggcaaaggc ctggaatggg tgtcccggat cagaagcaag      840

tacaacaact acgccaccta ctacgccgac agcgtgaagg gccggttcac catcagccgg      900

gacgacagca agaacaccct gtacctgcag atgaacagcc tgcgggccga ggacaccgcc      960

gtgtactatt gtgtgcggca cggcaacttc ggcaacagct atgtgtcttg gtttgcctac     1020

tggggccagg gcaccctcgt gaccgtgtca agcgctagcg tggccgctcc ctccgtgttt     1080

atctttcccc catccgatga acagctgaaa agcggcaccg cctccgtcgt gtgtctgctg     1140

aacaattttt accctaggga agctaaagtg cagtggaaag tggataacgc actgcagtcc     1200

ggcaactccc aggaatctgt gacagaacag gactccaagg acagcaccta ctccctgtcc     1260

tccaccctga cactgtctaa ggctgattat gagaaacaca aagtctacgc ctgcgaagtc     1320

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtgacaag     1380

acccacacct gtcccccttg tcctgcccct gaagctgctg gcggcccttc tgtgttcctg     1440

ttccccccaa agcccaagga caccctgatg atcagccgga cccccgaagt gacctgcgtg     1500

gtggtggatg tgtcccacga ggaccctgaa gtgaagttca attggtacgt ggacggcgtg     1560

gaagtgcaca acgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1620

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1680

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1740

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag     1800

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1860

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1920

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1980

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     2040

ctgtctccgg gtaaa                                                      2055


<210>  95
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCSP M4-3 (C1) (VH-CH1) - Fc(hole) P329GLALA

<400>  95
caggtgcaat tgcaggaaag cggccctggc ctggtcaagc ccagccagac cctgagcctg       60

acctgcaccg tgtccggcgg cagcatcacc agcggctatt attggaactg gattcggcag      120

caccccggca agggcctgga atggatcggc tacatcactt tcgacggctc taacaactac      180

aaccccagcc tgaagtccag agtgaccatc agccgggaca ccagcaagaa ccagttcagc      240

ctgaagctgt ccagcgtgac agccgccgac accgccgtgt actactgcgc cgacttcgac      300

tactggggcc agggcaccct ggtcaccgtg tccagcgcta gcaccaaggg cccctccgtg      360

ttccccctgg cccccagcag caagagcacc agcggcggca cagccgctct gggctgcctg      420

gtcaaggact acttccccga gcccgtgacc gtgtcctgga acagcggagc cctgacctcc      480

ggcgtgcaca ccttccccgc cgtgctgcag agttctggcc tgtatagcct gagcagcgtg      540

gtcaccgtgc cttctagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      600

cccagcaaca ccaaggtgga caagaaggtg gagcccaaga gctgcgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaagctgca gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt gcaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctc     1080

tcgtgcgcag tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctcgtgagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaa                                                                1326


<210>  96
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527 (Crossfab, VL-CH1)

<400>  96
caggccgtcg tgacccagga acccagcctg acagtgtctc ctggcggcac cgtgaccctg       60

acatgtggca gttctacagg cgccgtgacc accagcaact acgccaactg ggtgcaggaa      120

aagcccggcc aggccttcag aggactgatc ggcggcacca acaagagagc ccctggcacc      180

cctgccagat tcagcggatc tctgctggga ggaaaggccg ccctgacact gtctggcgcc      240

cagccagaag atgaggccga gtactactgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggca ccaagctgac agtgctgagc agcgcttcca ccaaaggccc ttccgtgttt      360

cctctggctc ctagctccaa gtccacctct ggaggcaccg ctgctctcgg atgcctcgtg      420

aaggattatt ttcctgagcc tgtgacagtg tcctggaata gcggagcact gacctctgga      480

gtgcatactt tccccgctgt gctgcagtcc tctggactgt acagcctgag cagcgtggtg      540

acagtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      600

agcaacacca aggtggacaa gaaggtggaa cccaagtctt gt                         642


<210>  97
<211>  2082
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA CH1A1A 98/99 - CD3 CH2527 (Crossfab VH-Ck) - Fc(knob) 
       P329GLALA

<400>  97
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggcc      120

cctggacagg gcctggaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accaccgaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctact atgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agtgctagca caaagggccc cagcgtgttc cctctggccc ctagcagcaa gagcacatct      420

ggcggaacag ccgccctggg ctgcctggtc aaggactact ttcccgagcc cgtgacagtg      480

tcctggaact ctggcgccct gacaagcggc gtgcacacct ttccagccgt gctgcagagc      540

agcggcctgt actctctgag cagcgtggtc accgtgccta gctctagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa      660

cccaagagct gcgatggcgg aggcggctcc ggaggcggag gatccgaggt gcagctgctg      720

gaatctggcg gcggactggt gcagcctggc ggatctctga gactgagctg tgccgccagc      780

ggcttcacct tcagcaccta cgccatgaac tgggtgcgcc aggcccctgg caaaggcctg      840

gaatgggtgt cccggatcag aagcaagtac aacaactacg ccacctacta cgccgacagc      900

gtgaagggcc ggttcaccat cagccgggac gacagcaaga acaccctgta cctgcagatg      960

aacagcctgc gggccgagga caccgccgtg tactattgtg tgcggcacgg caacttcggc     1020

aacagctatg tgtcttggtt tgcctactgg ggccagggca ccctcgtgac cgtgtcaagc     1080

gctagcgtgg ccgctccctc cgtgtttatc tttcccccat ccgatgaaca gctgaaaagc     1140

ggcaccgcct ccgtcgtgtg tctgctgaac aatttttacc ctagggaagc taaagtgcag     1200

tggaaagtgg ataacgcact gcagtccggc aactcccagg aatctgtgac agaacaggac     1260

tccaaggaca gcacctactc cctgtcctcc accctgacac tgtctaaggc tgattatgag     1320

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag     1380

agcttcaaca ggggagagtg tgacaagacc cacacctgtc ccccttgtcc tgcccctgaa     1440

gctgctggcg gcccttctgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc     1500

agccggaccc ccgaagtgac ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg     1560

aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagacaaa gccgcgggag     1620

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1680

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcggcgc ccccatcgag     1740

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1800

tgccgggatg agctgaccaa gaaccaggtc agcctgtggt gcctggtcaa aggcttctat     1860

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1920

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1980

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     2040

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        2082


<210>  98
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA CH1A1A 98/99 (VH-CH1) - Fc(hole) P329GLALA

<400>  98
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agcgctagca ccaagggccc ctccgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgctctggg ctgcctggtc aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagt      540

tctggcctgt atagcctgag cagcgtggtc accgtgcctt ctagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag      660

cccaagagct gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtgca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctctcg tgcgcagtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  99
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DP47 GS

<400>  99
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct gacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  100
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527 (Crossfab, VL-CH1)

<400>  100
caggccgtcg tgacccagga acccagcctg acagtgtctc ctggcggcac cgtgaccctg       60

acatgtggca gttctacagg cgccgtgacc accagcaact acgccaactg ggtgcaggaa      120

aagcccggcc aggccttcag aggactgatc ggcggcacca acaagagagc ccctggcacc      180

cctgccagat tcagcggatc tctgctggga ggaaaggccg ccctgacact gtctggcgcc      240

cagccagaag atgaggccga gtactactgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggca ccaagctgac agtgctgagc agcgcttcca ccaaaggccc ttccgtgttt      360

cctctggctc ctagctccaa gtccacctct ggaggcaccg ctgctctcgg atgcctcgtg      420

aaggattatt ttcctgagcc tgtgacagtg tcctggaata gcggagcact gacctctgga      480

gtgcatactt tccccgctgt gctgcagtcc tctggactgt acagcctgag cagcgtggtg      540

acagtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      600

agcaacacca aggtggacaa gaaggtggaa cccaagtctt gt                         642


<210>  101
<211>  2064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47 GS (VH-CH1) - CD3 CH2527 (Crossfab VH-Ck) - Fc(knob) 
       P329GLALA

<400>  101
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag cacaaagggc      360

cccagcgtgt tccctctggc ccctagcagc aagagcacat ctggcggaac agccgccctg      420

ggctgcctcg tgaaggacta ctttcccgag cctgtgaccg tgtcctggaa ctctggcgcc      480

ctgacaagcg gcgtgcacac ctttccagcc gtgctgcaga gcagcggcct gtactctctg      540

agcagcgtgg tcaccgtgcc tagcagcagc ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaagtggac aagaaggtgg agcccaagag ctgtgatggc      660

ggaggagggt ccggaggcgg aggatccgag gtgcagctgc tggaatctgg cggcggactg      720

gtgcagcctg gcggatctct gagactgagc tgtgccgcca gcggcttcac cttcagcacc      780

tacgccatga actgggtgcg ccaggcccct ggcaaaggcc tggaatgggt gtcccggatc      840

agaagcaagt acaacaacta cgccacctac tacgccgaca gcgtgaaggg ccggttcacc      900

atcagccggg acgacagcaa gaacaccctg tacctgcaga tgaacagcct gcgggccgag      960

gacaccgccg tgtactattg tgtgcggcac ggcaacttcg gcaacagcta tgtgtcttgg     1020

tttgcctact ggggccaggg caccctcgtg accgtgtcaa gcgctagcgt ggccgctccc     1080

tccgtgttta tctttccccc atccgatgaa cagctgaaaa gcggcaccgc ctccgtcgtg     1140

tgtctgctga acaattttta ccctagggaa gctaaagtgc agtggaaagt ggataacgca     1200

ctgcagtccg gcaactccca ggaatctgtg acagaacagg actccaagga cagcacctac     1260

tccctgtcct ccaccctgac actgtctaag gctgattatg agaaacacaa agtctacgcc     1320

tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag     1380

tgtgacaaga cccacacctg tcccccttgt cctgcccctg aagctgctgg cggcccttct     1440

gtgttcctgt tccccccaaa gcccaaggac accctgatga tcagccggac ccccgaagtg     1500

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg     1560

gacggcgtgg aagtgcacaa cgccaagaca aagccgcggg aggagcagta caacagcacg     1620

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1680

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1740

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1800

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1860

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1920

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1980

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     2040

agcctctccc tgtctccggg taaa                                            2064


<210>  102
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47 GS (VH-CH1) - Fc(hole) P329GLALA

<400>  102
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccctccgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgctctg      420

ggctgcctgg tcaaggacta cttccccgag cccgtgaccg tgtcctggaa cagcggagcc      480

ctgacctccg gcgtgcacac cttccccgcc gtgctgcaga gttctggcct gtatagcctg      540

agcagcgtgg tcaccgtgcc ttctagcagc ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgcgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgtg caccctgccc ccatcccggg atgagctgac caagaaccag     1080

gtcagcctct cgtgcgcagt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tcgtgagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  103
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  104
<211>  198
<212>  PRT
<213>  Macaca fascicularis

<400>  104

Met Gln Ser Gly Thr Arg Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Ile Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Gln Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Ser Gln His Leu Gly Ser Glu Ala Gln Trp Gln His Asn Gly Lys 
    50                  55                  60                  


Asn Lys Glu Asp Ser Gly Asp Arg Leu Phe Leu Pro Glu Phe Ser Glu 
65                  70                  75                  80  


Met Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Asn Pro 
                85                  90                  95      


Glu Asp Ala Ser His His Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn 
            100                 105                 110         


Cys Met Glu Met Asp Val Met Ala Val Ala Thr Ile Val Ile Val Asp 
        115                 120                 125             


Ile Cys Ile Thr Leu Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys 
    130                 135                 140                 


Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly 
145                 150                 155                 160 


Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn 
                165                 170                 175     


Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Gln Asp Leu Tyr Ser Gly 
            180                 185                 190         


Leu Asn Gln Arg Arg Ile 
        195             


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  105

Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  106

Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  107
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  107

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  108
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  108

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  109
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  109
atggactgga cctggagaat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  110
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  110
atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  111
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  111

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys 
            20          


<210>  112
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  112
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgt                                                                  66


<210>  113
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  113

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  114
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  114
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcc          57


<210>  115
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  115
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccactggagt gcattcc          57


<210>  116
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader peptide

<400>  116
atgggctggt cctgcatcat cctgtttctg gtcgccacag ccaccggcgt gcactct          57


<210>  117
<211>  643
<212>  PRT
<213>  Macaca fascicularis

<400>  117

Leu Ser Leu Glu Gly Ser Arg Thr Leu Thr Val Cys Pro Gly Ser Val 
1               5                   10                  15      


Gln Pro Leu Ser Ser Gln Thr Leu Arg Ala Ser Ser Ser Ala Gly Thr 
            20                  25                  30          


Asp Pro Gln Leu Leu Leu Tyr Arg Val Val Arg Gly Pro Gln Leu Gly 
        35                  40                  45              


Arg Leu Phe His Ala Gln Gln Asp Ser Thr Gly Glu Ala Leu Val Asn 
    50                  55                  60                  


Phe Thr Gln Ala Glu Val Tyr Ala Gly Asn Ile Leu Tyr Glu His Glu 
65                  70                  75                  80  


Met Pro Thr Glu Pro Phe Trp Glu Ala His Asp Thr Leu Glu Leu Gln 
                85                  90                  95      


Leu Ser Ser Pro Pro Ala Arg Asp Val Ala Ala Thr Leu Ala Val Ala 
            100                 105                 110         


Val Ser Phe Glu Ala Ala Cys Pro Gln Arg Pro Ser His Leu Trp Lys 
        115                 120                 125             


Asn Lys Gly Leu Trp Val Pro Glu Gly Gln Arg Ala Lys Ile Thr Met 
    130                 135                 140                 


Ala Ala Leu Asp Ala Ser Asn Leu Leu Ala Ser Val Pro Ser Pro Gln 
145                 150                 155                 160 


Arg Leu Glu His Asp Val Leu Phe Gln Val Thr Gln Phe Pro Ser Arg 
                165                 170                 175     


Gly Gln Leu Leu Val Ser Glu Glu Pro Leu His Ala Gly Gln Pro His 
            180                 185                 190         


Phe Leu Gln Ser Gln Leu Ala Ala Gly Gln Leu Val Tyr Ala His Gly 
        195                 200                 205             


Gly Gly Gly Thr Gln Gln Asp Gly Phe His Phe Arg Ala His Leu Gln 
    210                 215                 220                 


Gly Pro Ala Gly Ala Thr Val Ala Gly Pro Gln Thr Ser Glu Ala Phe 
225                 230                 235                 240 


Ala Ile Thr Val Arg Asp Val Asn Glu Arg Pro Pro Gln Pro Gln Ala 
                245                 250                 255     


Ser Val Pro Leu Arg Ile Thr Arg Gly Ser Arg Ala Pro Ile Ser Arg 
            260                 265                 270         


Ala Gln Leu Ser Val Val Asp Pro Asp Ser Ala Pro Gly Glu Ile Glu 
        275                 280                 285             


Tyr Glu Val Gln Arg Ala Pro His Asn Gly Phe Leu Ser Leu Val Gly 
    290                 295                 300                 


Gly Gly Pro Gly Pro Val Thr His Phe Thr Gln Ala Asp Val Asp Ser 
305                 310                 315                 320 


Gly Arg Leu Ala Phe Val Ala Asn Gly Ser Ser Val Ala Gly Val Phe 
                325                 330                 335     


Gln Leu Ser Met Ser Asp Gly Ala Ser Pro Pro Leu Pro Met Ser Leu 
            340                 345                 350         


Ala Val Asp Ile Leu Pro Ser Ala Ile Glu Val Gln Leu Gln Ala Pro 
        355                 360                 365             


Leu Glu Val Pro Gln Ala Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln 
    370                 375                 380                 


Leu Arg Val Val Ser Asp Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu 
385                 390                 395                 400 


Ile Gln Gly Pro Lys Tyr Gly His Leu Leu Val Gly Gly Arg Pro Ala 
                405                 410                 415     


Ser Ala Phe Ser Gln Leu Gln Ile Asp Gln Gly Glu Val Val Phe Ala 
            420                 425                 430         


Phe Thr Asn Phe Ser Ser Ser His Asp His Phe Arg Val Leu Ala Leu 
        435                 440                 445             


Ala Arg Gly Val Asn Ala Ser Ala Val Val Asn Ile Thr Val Arg Ala 
    450                 455                 460                 


Leu Leu His Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu 
465                 470                 475                 480 


Arg Leu Asp Pro Thr Ile Leu Asp Ala Gly Glu Leu Ala Asn Arg Thr 
                485                 490                 495     


Gly Ser Val Pro His Phe Arg Leu Leu Glu Gly Pro Arg His Gly Arg 
            500                 505                 510         


Val Val Arg Val Pro Arg Ala Arg Thr Glu Pro Gly Gly Ser Gln Leu 
        515                 520                 525             


Val Glu Gln Phe Thr Gln Gln Asp Leu Glu Asp Gly Arg Leu Gly Leu 
    530                 535                 540                 


Glu Val Gly Arg Pro Glu Gly Arg Ala Pro Ser Pro Thr Gly Asp Ser 
545                 550                 555                 560 


Leu Thr Leu Glu Leu Trp Ala Gln Gly Val Pro Pro Ala Val Ala Ser 
                565                 570                 575     


Leu Asp Phe Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val 
            580                 585                 590         


Ala Leu Leu Ser Val Pro Glu Ala Thr Arg Met Glu Ala Gly Lys Pro 
        595                 600                 605             


Glu Ser Ser Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro 
    610                 615                 620                 


Val Pro Ala Val Ala Lys Gly Gly Phe Leu Gly Phe Leu Glu Ala Asn 
625                 630                 635                 640 


Met Phe Ser 
            


<210>  118
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  118

Leu Ser Leu Lys Gly Ser Gln Thr Leu Thr Val Cys Pro Gly Ser Val 
1               5                   10                  15      


Gln Pro Leu Ser Ser Gln Thr Leu Arg Ala Ser Ser Ser Ala Gly Thr 
            20                  25                  30          


Asp Pro Gln Leu Leu Leu Tyr Arg Val Val Arg Gly Pro Gln Leu Gly 
        35                  40                  45              


Arg Leu Phe His Ala Gln Gln Asp Ser Thr Gly Glu Ala Leu Val Asn 
    50                  55                  60                  


Phe Thr Gln Ala Glu Val Tyr Ala Gly Asn Ile Leu Tyr Glu His Glu 
65                  70                  75                  80  


Met Pro Pro Glu Pro Phe Trp Glu Ala His Asp Thr Leu Glu Leu Gln 
                85                  90                  95      


Leu Ser Ser Pro Pro Ala Arg Asp Val Ala Ala Thr Leu Ala Val Ala 
            100                 105                 110         


Val Ser Phe Glu Ala Ala Cys Pro Gln His Pro Ser His Leu Trp Lys 
        115                 120                 125             


Asn Lys Gly Leu Trp Val Pro Glu Gly Gln Arg Ala Arg Ile Thr Val 
    130                 135                 140                 


Ala Ala Leu Asp Ala Ser Asn Leu Leu Ala Ser Val Pro Ser Pro Gln 
145                 150                 155                 160 


Arg Ser Glu His Asp Val Leu Phe Gln Val Thr Gln Phe Pro Ser Arg 
                165                 170                 175     


Gly Gln Leu Leu Val Ser Glu Glu Pro Leu His Ala Gly Gln Pro His 
            180                 185                 190         


Phe Leu Gln Ser Gln Leu Ala Ala Gly Gln Leu Val Tyr Ala His Gly 
        195                 200                 205             


Gly Gly Gly Thr Gln Gln Asp Gly Phe His Phe Arg Ala His Leu Gln 
    210                 215                 220                 


Gly Pro Ala Gly Ala Ser Val Ala Gly Pro Gln Thr Ser Glu Ala Phe 
225                 230                 235                 240 


Ala Ile Thr Val Arg Asp Val Asn Glu Arg Pro Pro Gln Pro Gln Ala 
                245                 250                 255     


Ser Val Pro Leu Arg Leu Thr Arg Gly Ser Arg Ala Pro Ile Ser Arg 
            260                 265                 270         


Ala Gln Leu Ser Val Val Asp Pro Asp Ser Ala Pro Gly Glu Ile Glu 
        275                 280                 285             


Tyr Glu Val Gln Arg Ala Pro His Asn Gly Phe Leu Ser Leu Val Gly 
    290                 295                 300                 


Gly Gly Leu Gly Pro Val Thr Arg Phe Thr Gln Ala Asp Val Asp Ser 
305                 310                 315                 320 


Gly Arg Leu Ala Phe Val Ala Asn Gly Ser Ser Val Ala Gly Ile Phe 
                325                 330                 335     


Gln Leu Ser Met Ser Asp Gly Ala Ser Pro Pro Leu Pro Met Ser Leu 
            340                 345                 350         


Ala Val Asp Ile Leu Pro Ser Ala Ile Glu Val Gln Leu Arg Ala Pro 
        355                 360                 365             


Leu Glu Val Pro Gln Ala Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln 
    370                 375                 380                 


Leu Arg Val Val Ser Asp Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu 
385                 390                 395                 400 


Ile Gln Gly Pro Gln Tyr Gly His Leu Leu Val Gly Gly Arg Pro Thr 
                405                 410                 415     


Ser Ala Phe Ser Gln Phe Gln Ile Asp Gln Gly Glu Val Val Phe Ala 
            420                 425                 430         


Phe Thr Asn Phe Ser Ser Ser His Asp His Phe Arg Val Leu Ala Leu 
        435                 440                 445             


Ala Arg Gly Val Asn Ala Ser Ala Val Val Asn Val Thr Val Arg Ala 
    450                 455                 460                 


Leu Leu His Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu 
465                 470                 475                 480 


Arg Leu Asp Pro Thr Val Leu Asp Ala Gly Glu Leu Ala Asn Arg Thr 
                485                 490                 495     


Gly Ser Val Pro Arg Phe Arg Leu Leu Glu Gly Pro Arg His Gly Arg 
            500                 505                 510         


Val Val Arg Val Pro Arg Ala Arg Thr Glu Pro Gly Gly Ser Gln Leu 
        515                 520                 525             


Val Glu Gln Phe Thr Gln Gln Asp Leu Glu Asp Gly Arg Leu Gly Leu 
    530                 535                 540                 


Glu Val Gly Arg Pro Glu Gly Arg Ala Pro Gly Pro Ala Gly Asp Ser 
545                 550                 555                 560 


Leu Thr Leu Glu Leu Trp Ala Gln Gly Val Pro Pro Ala Val Ala Ser 
                565                 570                 575     


Leu Asp Phe Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val 
            580                 585                 590         


Ala Leu Leu Ser Val Pro Glu Ala Ala Arg Thr Glu Ala Gly Lys Pro 
        595                 600                 605             


Glu Ser Ser Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro 
    610                 615                 620                 


Glu Pro Ala Val Ala Lys Gly Gly Phe Leu Ser Phe Leu Glu Ala Asn 
625                 630                 635                 640 


Met Phe Ser 
            


<210>  119
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NABA-avi-his

<400>  119

Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Met Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg Ile Asn 
225                 230                 235                 240 


Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys Ile Thr 
                245                 250                 255     


Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr 
            260                 265                 270         


Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Ile Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Leu Ile Asn Val Asp Leu Glu Val Leu Phe Gln 
385                 390                 395                 400 


Gly Pro Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
                405                 410                 415     


Trp His Glu Ala Arg Ala His His His His His His 
            420                 425             


<210>  120
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3e stalk-Fc(knob)-Avi

<400>  120

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Ser Glu Asn Cys Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser 
            100                 105                 110         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        115                 120                 125             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    130                 135                 140                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
145                 150                 155                 160 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                165                 170                 175     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            180                 185                 190         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        195                 200                 205             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    210                 215                 220                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
225                 230                 235                 240 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
                245                 250                 255     


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            260                 265                 270         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        275                 280                 285             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    290                 295                 300                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
305                 310                 315                 320 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                325                 330                 335     


Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu 
            340                 345                 350         


Ala Gln Lys Ile Glu Trp His Glu 
        355                 360 


<210>  121
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3d stalk-Fc(hole)

<400>  121

Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys 
1               5                   10                  15      


Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser 
            20                  25                  30          


Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly 
        35                  40                  45              


Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr 
    50                  55                  60                  


Val Gln Val His Tyr Arg Met Cys Arg Ser Glu Gln Leu Tyr Phe Gln 
65                  70                  75                  80  


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                85                  90                  95      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            100                 105                 110         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        115                 120                 125             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    130                 135                 140                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
145                 150                 155                 160 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                165                 170                 175     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            180                 185                 190         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        195                 200                 205             


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    210                 215                 220                 


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
225                 230                 235                 240 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                245                 250                 255     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            260                 265                 270         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        275                 280                 285             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    290                 295                 300                 


Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys 
305                 310                 315                 320 


Ile Glu Trp His Glu 
                325 


<210>  122
<211>  658
<212>  PRT
<213>  Mus musculus

<400>  122

Leu Ser Leu Glu Gly Thr Arg Lys Leu Thr Val Cys Pro Glu Ser Val 
1               5                   10                  15      


Gln Pro Leu Ser Ser Gln Ser Leu Ser Ala Ser Ser Ser Thr Gly Ala 
            20                  25                  30          


Asp Pro Arg His Leu Leu Tyr Arg Val Val Arg Gly Pro Gln Leu Gly 
        35                  40                  45              


Arg Leu Leu His Ala Gln Gln Gly Ser Ala Glu Glu Val Leu Val Asn 
    50                  55                  60                  


Phe Thr Gln Ala Glu Val Asn Ala Gly Asn Ile Leu Tyr Glu His Glu 
65                  70                  75                  80  


Met Ser Ser Glu Pro Phe Trp Glu Ala His Asp Thr Ile Gly Leu Leu 
                85                  90                  95      


Leu Ser Ser Pro Pro Ala Arg Asp Leu Ala Ala Thr Leu Ala Val Met 
            100                 105                 110         


Val Ser Phe Asp Ala Ala Cys Pro Gln Arg Pro Ser Arg Leu Trp Lys 
        115                 120                 125             


Asn Lys Gly Leu Trp Val Pro Glu Gly Gln Arg Ala Lys Ile Thr Val 
    130                 135                 140                 


Ala Ala Leu Asp Ala Ala Asn Leu Leu Ala Ser Val Pro Ala Ser Gln 
145                 150                 155                 160 


Arg Ser Arg His Asp Val Leu Phe Gln Val Thr Gln Phe Pro Thr Arg 
                165                 170                 175     


Gly Gln Leu Leu Val Ser Glu Glu Pro Leu His Ala Arg Arg Pro Tyr 
            180                 185                 190         


Phe Leu Gln Ser Glu Leu Ala Ala Gly Gln Leu Val Tyr Ala His Gly 
        195                 200                 205             


Gly Gly Gly Thr Gln Gln Asp Gly Phe Arg Phe Arg Ala His Leu Gln 
    210                 215                 220                 


Gly Pro Thr Gly Thr Ser Val Ala Gly Pro Gln Thr Ser Glu Ala Phe 
225                 230                 235                 240 


Val Ile Thr Val Arg Asp Val Asn Glu Arg Pro Pro Gln Pro Gln Ala 
                245                 250                 255     


Ser Ile Pro Leu Arg Val Thr Arg Gly Ser Arg Ala Pro Val Ser Arg 
            260                 265                 270         


Ala Gln Leu Ser Val Val Asp Pro Asp Ser Ala Pro Gly Glu Ile Glu 
        275                 280                 285             


Tyr Glu Val Gln Arg Ala Pro His Asn Gly Phe Leu Ser Leu Ala Gly 
    290                 295                 300                 


Asp Asn Thr Gly Pro Val Thr His Phe Thr Gln Ala Asp Val Asp Ala 
305                 310                 315                 320 


Gly Arg Leu Ala Phe Val Ala Asn Gly Ser Ser Val Ala Gly Val Phe 
                325                 330                 335     


Gln Leu Ser Met Ser Asp Gly Ala Ser Pro Pro Ile Pro Met Ser Leu 
            340                 345                 350         


Ala Val Asp Val Leu Pro Ser Thr Ile Glu Val Gln Leu Arg Ala Pro 
        355                 360                 365             


Leu Glu Val Pro Gln Ala Leu Gly Arg Thr Ser Leu Ser Arg Gln Gln 
    370                 375                 380                 


Leu Gln Val Ile Ser Asp Arg Glu Glu Pro Asp Val Ala Tyr Arg Leu 
385                 390                 395                 400 


Thr Gln Gly Pro Leu Tyr Gly Gln Leu Leu Val Gly Gly Gln Pro Ala 
                405                 410                 415     


Ser Ala Phe Ser Gln Leu Gln Val Asp Gln Gly Asp Val Val Phe Val 
            420                 425                 430         


Phe Thr Asn Phe Ser Ser Ser Gln Asp His Phe Lys Val Val Ala Leu 
        435                 440                 445             


Ala Arg Gly Val Asn Ala Ser Ala Thr Val Asn Val Thr Val Gln Ala 
    450                 455                 460                 


Leu Leu His Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Thr Thr Leu 
465                 470                 475                 480 


Arg Leu Asp Pro Thr Val Leu Asp Ala Ser Glu Leu Ala Asn Arg Thr 
                485                 490                 495     


Gly Ser Met Pro His Phe Arg Leu Leu Ala Gly Pro Arg Tyr Gly Arg 
            500                 505                 510         


Val Val Arg Val Ser Gln Gly Arg Thr Glu Ser Arg Ser Asn Gln Leu 
        515                 520                 525             


Val Glu His Phe Thr Gln Arg Asp Leu Glu Glu Gly Gln Leu Gly Leu 
    530                 535                 540                 


Glu Val Gly Lys Pro Glu Gly Arg Ser Thr Gly Pro Ala Gly Asp Arg 
545                 550                 555                 560 


Leu Thr Leu Glu Leu Trp Ala Lys Gly Val Pro Pro Ala Val Ala Leu 
                565                 570                 575     


Leu Asp Phe Ala Thr Glu Pro Tyr His Ala Ala Lys Ser Tyr Ser Val 
            580                 585                 590         


Ala Leu Leu Ser Val Pro Glu Ala Val Arg Thr Glu Thr Glu Lys Pro 
        595                 600                 605             


Gly Arg Ser Val Pro Thr Gly Gln Pro Gly Gln Ala Ala Ser Ser Pro 
    610                 615                 620                 


Val Pro Thr Ala Ala Lys Gly Gly Val Asp Gly Leu Asn Asp Ile Phe 
625                 630                 635                 640 


Glu Ala Gln Lys Ile Glu Trp His Glu Ala Arg Ala His His His His 
                645                 650                 655     


His His 
        


