                         SEQUENCE LISTING

<110>  CSL Behring AG
 
<120>  Treatment and Prevention of Remote Ischemia-Reperfusion Injury

<130>  A216

<150>  EP2013158478
<151>  2013-03-08

<160>  18     

<170>  PatentIn version 3.5

<210>  1
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  1

Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln Asp Pro Glu Ser Leu Gln 
1               5                   10                  15      


Asp Arg Gly Glu Gly Lys Val Ala Thr Thr Val Ile Ser Lys Met Leu 
            20                  25                  30          


Phe Val Glu Pro Ile Leu Glu Val Ser Ser Leu Pro Thr Thr Asn Ser 
        35                  40                  45              


Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala Asn Thr Thr Asp Glu Pro 
    50                  55                  60                  


Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr Gln Pro Thr Ile Gln Pro 
65                  70                  75                  80  


Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp Ser Pro Thr Gln Pro Thr 
                85                  90                  95      


Thr Gly Ser Phe Cys Pro Gly Pro Val Thr Leu Cys Ser Asp Leu Glu 
            100                 105                 110         


Ser His Ser Thr Glu Ala Val Leu Gly Asp Ala Leu Val Asp Phe Ser 
        115                 120                 125             


Leu Lys Leu Tyr His Ala Phe Ser Ala Met Lys Lys Val Glu Thr Asn 
    130                 135                 140                 


Met Ala Phe Ser Pro Phe Ser Ile Ala Ser Leu Leu Thr Gln Val Leu 
145                 150                 155                 160 


Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn Leu Glu Ser Ile Leu Ser 
                165                 170                 175     


Tyr Pro Lys Asp Phe Thr Cys Val His Gln Ala Leu Lys Gly Phe Thr 
            180                 185                 190         


Thr Lys Gly Val Thr Ser Val Ser Gln Ile Phe His Ser Pro Asp Leu 
        195                 200                 205             


Ala Ile Arg Asp Thr Phe Val Asn Ala Ser Arg Thr Leu Tyr Ser Ser 
    210                 215                 220                 


Ser Pro Arg Val Leu Ser Asn Asn Ser Asp Ala Asn Leu Glu Leu Ile 
225                 230                 235                 240 


Asn Thr Trp Val Ala Lys Asn Thr Asn Asn Lys Ile Ser Arg Leu Leu 
                245                 250                 255     


Asp Ser Leu Pro Ser Asp Thr Arg Leu Val Leu Leu Asn Ala Ile Tyr 
            260                 265                 270         


Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp Pro Lys Lys Thr Arg Met 
        275                 280                 285             


Glu Pro Phe His Phe Lys Asn Ser Val Ile Lys Val Pro Met Met Asn 
    290                 295                 300                 


Ser Lys Lys Tyr Pro Val Ala His Phe Ile Asp Gln Thr Leu Lys Ala 
305                 310                 315                 320 


Lys Val Gly Gln Leu Gln Leu Ser His Asn Leu Ser Leu Val Ile Leu 
                325                 330                 335     


Val Pro Gln Asn Leu Lys His Arg Leu Glu Asp Met Glu Gln Ala Leu 
            340                 345                 350         


Ser Pro Ser Val Phe Lys Ala Ile Met Glu Lys Leu Glu Met Ser Lys 
        355                 360                 365             


Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg Ile Lys Val Thr Thr Ser 
    370                 375                 380                 


Gln Asp Met Leu Ser Ile Met Glu Lys Leu Glu Phe Phe Asp Phe Ser 
385                 390                 395                 400 


Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu Asp Pro Asp Leu Gln Val 
                405                 410                 415     


Ser Ala Met Gln His Gln Thr Val Leu Glu Leu Thr Glu Thr Gly Val 
            420                 425                 430         


Glu Ala Ala Ala Ala Ser Ala Ile Ser Val Ala Arg Thr Leu Leu Val 
        435                 440                 445             


Phe Glu Val Gln Gln Pro Phe Leu Phe Val Leu Trp Asp Gln Gln His 
    450                 455                 460                 


Lys Phe Pro Val Phe Met Gly Arg Val Tyr Asp Pro Arg Ala 
465                 470                 475             


<210>  2
<211>  48
<212>  PRT
<213>  Trioma infestans

<400>  2

Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn Tyr Val Pro Val Cys 
1               5                   10                  15      


Gly Ser Asp Gly Lys Thr Tyr Gly Asn Pro Cys Met Leu Asn Cys Ala 
            20                  25                  30          


Ala Gln Thr Lys Val Pro Gly Leu Lys Leu Val His Glu Gly Arg Cys 
        35                  40                  45              


<210>  3
<211>  56
<212>  PRT
<213>  Homo sapiens
<223>  SPINK-1

<400>  3

Asp Ser Leu Gly Arg Glu Ala Lys Cys Tyr Asn Glu Leu Asn Gly Cys 
1               5                   10                  15      


Thr Lys Ile Tyr Asp Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Pro 
            20                  25                  30          


Asn Glu Cys Val Leu Cys Phe Glu Asn Arg Lys Arg Gln Thr Ser Ile 
        35                  40                  45              


Leu Ile Gln Lys Ser Gly Pro Cys 
    50                  55      


<210>  4
<400>  4
000


<210>  5
<400>  5
000


<210>  6
<400>  6
000


<210>  7
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  8
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  9
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  9

Lys Tyr Ile Met Gln 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial


<220>
<223>  Heavy chain CDR2 showing variations

<220>  
<221>  V-segment
<222>  (3)..(3)
<223>  Xaa is selected from Arg, Asn, and Asp

<220>  
<221>  V-segment
<222>  (4)..(4)
<223>  Xaa is selcted from Pro, Val, Ile and Met

<220>  
<221>  V-segment
<222>  (5)..(5)
<223>  Xaa is selected from Ser, Pro and Ala

<220>  
<221>  V-segment
<222>  (6)..(6)
<223>  Xaa is selected from Gly, Leu, Val and Thr

<220>  
<221>  V-segment
<222>  (7)..(7)
<223>  Xaa is selected from Gly, Tyr, Gln, Lys, Arg, Asn and Met

<220>  
<221>  V-segment
<222>  (8)..(8)
<223>  Xaa is selected from Thr, Gly and Ser



<400>  11

Gly Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial


<220>
<223>  Heavy chain CDR3 showing variations

<220>  
<221>  V-segment
<222>  (9)..(9)
<223>  Xaa is selected from Ala, Met and Val

<220>  
<221>  V-segment
<222>  (10)..(10)
<223>  Xaa is selcted from Ser and Lys

<220>  
<221>  V-segment
<222>  (11)..(11)
<223>  Xaa is selected from Pro, Lys, Thr and His

<220>  
<221>  V-segment
<222>  (12)..(12)
<223>  Xaa is selected from His, Asn, Gly and Gln

<400>  13

Ala Leu Pro Arg Ser Gly Tyr Leu Xaa Xaa Xaa Xaa Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  14
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Tyr Val Tyr 
1               5                   10              


<210>  15
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  15

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Ala Trp Asp Ala Ser Leu Arg Gly Val 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>  
<221>  V-segment
<222>  (2)..(2)
<223>  Xaa is selected from Ala and Ser

<220>  
<221>  V-segment
<222>  (4)..(6)
<223>  Xaa can be any amino acid

<220>  
<221>  V-segment
<222>  (7)..(7)
<223>  Xaa is selected from Leu and Val

<220>  
<221>  V-segment
<222>  (9)..(10)
<223>  Xaa can be any amino acid

<400>  17

Ala Xaa Trp Xaa Xaa Xaa Xaa Arg Xaa Xaa 
1               5                   10  


<210>  18
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Gly Ser Ser Glu Met Thr Val His His Tyr Val Tyr 
1               5                   10              






