                         SEQUENCE LISTING

<110>  Biocrine AB
 
<120>  Methods for treating and/or limiting development of diabetes

<130>  150-334 PCT

<150>  61/779508
<151>  2013-03-13

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  2

<400>  2
000

<210>  3
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Val Phe Val Arg Arg Pro Trp Pro Ala Leu Thr Thr Val Leu Leu 
1               5                   10                  15      


Ala Leu Leu Val Cys Leu Gly Ala Leu Val Asp Ala Tyr Pro Ile Lys 
            20                  25                  30          


Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu Asn Arg Tyr 
        35                  40                  45              


Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Asp Gly Pro Asp Thr Leu Leu Ser Lys Thr Phe Phe Pro 
65                  70                  75                  80  


Asp Gly Glu Asp Arg Pro Val Arg Ser Arg Ser Glu Gly Pro Asp Leu 
                85                  90                  95      


Trp 
    


<210>  4
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Leu Gly Asn Lys Arg Leu Gly Leu Ser Gly Leu Thr Leu Ala Leu 
1               5                   10                  15      


Ser Leu Leu Val Cys Leu Gly Ala Leu Ala Glu Ala Tyr Pro Ser Lys 
            20                  25                  30          


Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp Met Ala Arg Tyr 
        35                  40                  45              


Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Ser Ser Pro Glu Thr Leu Ile Ser Asp Leu Leu Met Arg 
65                  70                  75                  80  


Glu Ser Thr Glu Asn Val Pro Arg Thr Arg Leu Glu Asp Pro Ala Met 
                85                  90                  95      


Trp 
    


<210>  5
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Ala Ala Ala Arg Leu Cys Leu Ser Leu Leu Leu Leu Ser Thr Cys 
1               5                   10                  15      


Val Ala Leu Leu Leu Gln Pro Leu Leu Gly Ala Gln Gly Ala Pro Leu 
            20                  25                  30          


Glu Pro Val Tyr Pro Gly Asp Asn Ala Thr Pro Glu Gln Met Ala Gln 
        35                  40                  45              


Tyr Ala Ala Asp Leu Arg Arg Tyr Ile Asn Met Leu Thr Arg Pro Arg 
    50                  55                  60                  


Tyr Gly Lys Arg His Lys Glu Asp Thr Leu Ala Phe Ser Glu Trp Gly 
65                  70                  75                  80  


Ser Pro His Ala Ala Val Pro Arg Glu Leu Ser Pro Leu Asp Leu 
                85                  90                  95  


<210>  6
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Lys Ile Ile Leu Trp Leu Cys Val Phe Gly Leu Phe Leu Ala Thr 
1               5                   10                  15      


Leu Phe Pro Ile Ser Trp Gln Met Pro Val Glu Ser Gly Leu Ser Ser 
            20                  25                  30          


Glu Asp Ser Ala Ser Ser Glu Ser Phe Ala Ser Lys Ile Lys Arg His 
        35                  40                  45              


Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu Glu 
    50                  55                  60                  


Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Ser 
65                  70                  75                  80  


Gly Ala Pro Pro Pro Ser Gly 
                85          


<210>  7
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Val Pro Lys Ala Asp Ser Gly Ala Phe Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Val Leu Thr Val Thr Glu Pro Leu Arg Pro Glu Leu Arg Cys Asn Pro 
            20                  25                  30          


Gly Gln Phe Ala Cys Arg Ser Gly Thr Ile Gln Cys Ile Pro Leu Pro 
        35                  40                  45              


Trp Gln Cys Asp Gly Trp Ala Thr Cys Glu Asp Glu Ser Asp Glu Ala 
    50                  55                  60                  


Asn Cys Pro Glu Val Thr Gly Glu Val Arg Pro His His Gly Lys Glu 
65                  70                  75                  80  


Ala Val Asp Pro Arg Gln Gly Arg Ala Arg Gly Gly Asp Pro Ser His 
                85                  90                  95      


Phe His Ala Val Asn Val Ala Gln Pro Val Arg Phe Ser Ser Phe Leu 
            100                 105                 110         


Gly Lys Cys Pro Thr Gly Trp His His Tyr Glu Gly Thr Ala Ser Cys 
        115                 120                 125             


Tyr Arg Val Tyr Leu Ser Gly Glu Asn Tyr Trp Asp Ala Ala Gln Thr 
    130                 135                 140                 


Cys Gln Arg Leu Asn Gly Ser Leu Ala Thr Phe Ser Thr Asp Gln Glu 
145                 150                 155                 160 


Leu Arg Phe Val Leu Ala Gln Glu Trp Asp Gln Pro Glu Arg Ser Phe 
                165                 170                 175     


Gly Trp Lys Asp Gln Arg Lys Leu Trp Val Gly Tyr Gln Tyr Val Ile 
            180                 185                 190         


Thr Gly Arg Asn Arg Ser Leu Glu Gly Arg Trp Glu Val Ala Phe Lys 
        195                 200                 205             


Gly Ser Ser Glu Val Phe Leu Pro Pro Asp Pro Ile Phe Ala Ser Ala 
    210                 215                 220                 


Met Ser Glu Asn Asp Asn Val Phe Cys Ala Gln Leu Gln Cys Phe His 
225                 230                 235                 240 


Phe Pro Thr Leu Arg His His Asp Leu His Ser Trp His Ala Glu Ser 
                245                 250                 255     


Cys Tyr Glu Lys Ser Ser Phe Leu Cys Lys Arg Ser Gln Thr Cys Val 
            260                 265                 270         


Asp Ile Lys Asp Asn Val Val Asp Glu Gly Phe Tyr Phe Thr Pro Lys 
        275                 280                 285             


Gly Asp Asp Pro Cys Leu Ser Cys Thr Cys His Gly Gly Glu Pro Glu 
    290                 295                 300                 


Met Cys Val Ala Ala Leu Cys Glu Arg Pro Gln Gly Cys Gln Gln Tyr 
305                 310                 315                 320 


Arg Lys Asp Pro Lys Glu Cys Cys Lys Phe Met Cys Leu Asp Pro Asp 
                325                 330                 335     


Gly Asn Ser Leu Phe Asp Ser Met Ala Ser Gly Met Arg Leu Val Val 
            340                 345                 350         


Ser Cys Ile Ser Ser Phe Leu Ile Leu Ser Leu Leu Leu Phe Met Val 
        355                 360                 365             


His Arg Leu Arg Gln Arg Arg Arg Glu Arg Ile Glu Ser Leu Ile Gly 
    370                 375                 380                 


Ala Asn Leu His His Phe Asn Leu Gly Arg Arg Ile Pro Gly Phe Asp 
385                 390                 395                 400 


Tyr Gly Pro Asp Gly Phe Gly Thr Gly Leu Thr Pro Leu His Leu Ser 
                405                 410                 415     


Asp Asp Gly Glu Gly Gly Thr Phe His Phe His Asp Pro Pro Pro Pro 
            420                 425                 430         


Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile Gly Gln Pro Asp Asp Pro Pro 
        435                 440                 445             


Pro Pro Tyr Glu Ala Ser Ile His Pro Asp Ser Val Phe Tyr Asp Pro 
    450                 455                 460                 


Ala Asp Asp Asp Ala Phe Glu Pro Val Glu Val Ser Leu Pro Ala Pro 
465                 470                 475                 480 


Gly Asp Gly Gly Ser Glu Gly Ala Leu Leu Arg Arg Leu Glu Gln Pro 
                485                 490                 495     


Leu Pro Thr Ala Gly Ala Ser Leu Ala Asp Leu Glu Asp Ser Ala Asp 
            500                 505                 510         


Ser Ser Ser Ala Leu Leu Val Pro Pro Asp Pro Ala Gln Ser Gly Ser 
        515                 520                 525             


Thr Pro Ala Ala Glu Ala Leu Pro Gly Gly Gly Arg His Ser Arg Ser 
    530                 535                 540                 


Ser Leu Asn Thr Val Val 
545                 550 


<210>  8
<211>  1859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Val Asp Lys Asn Ile Tyr Ile Ile Gln Gly Glu Ile Asn Ile Val 
1               5                   10                  15      


Val Gly Ala Ile Lys Arg Asn Ala Arg Trp Ser Thr His Thr Pro Leu 
            20                  25                  30          


Asp Glu Glu Arg Asp Pro Leu Leu His Ser Phe Gly His Leu Lys Glu 
        35                  40                  45              


Val Leu Asn Ser Ile Thr Glu Leu Ser Glu Ile Glu Pro Asn Val Phe 
    50                  55                  60                  


Leu Arg Pro Phe Leu Glu Val Ile Arg Ser Glu Asp Thr Thr Gly Pro 
65                  70                  75                  80  


Ile Thr Gly Leu Ala Leu Thr Ser Val Asn Lys Phe Leu Ser Tyr Ala 
                85                  90                  95      


Leu Ile Asp Pro Thr His Glu Gly Thr Ala Glu Gly Met Glu Asn Met 
            100                 105                 110         


Ala Asp Ala Val Thr His Ala Arg Phe Val Gly Thr Asp Pro Ala Ser 
        115                 120                 125             


Asp Glu Val Val Leu Met Lys Ile Leu Gln Val Leu Arg Thr Leu Leu 
    130                 135                 140                 


Leu Thr Pro Val Gly Ala His Leu Thr Asn Glu Ser Val Cys Glu Ile 
145                 150                 155                 160 


Met Gln Ser Cys Phe Arg Ile Cys Phe Glu Met Arg Leu Ser Glu Leu 
                165                 170                 175     


Leu Arg Lys Ser Ala Glu His Thr Leu Val Asp Met Val Gln Leu Leu 
            180                 185                 190         


Phe Thr Arg Leu Pro Gln Phe Lys Glu Glu Pro Lys Asn Tyr Val Gly 
        195                 200                 205             


Thr Asn Met Lys Lys Leu Lys Met Arg Ala Gly Gly Met Ser Asp Ser 
    210                 215                 220                 


Ser Lys Trp Lys Lys Gln Lys Arg Ser Pro Arg Pro Pro Arg His Met 
225                 230                 235                 240 


Thr Lys Val Thr Pro Gly Ser Glu Leu Pro Thr Pro Asn Gly Thr Thr 
                245                 250                 255     


Leu Ser Ser Asn Leu Thr Gly Gly Met Pro Phe Ile Asp Val Pro Thr 
            260                 265                 270         


Pro Ile Ser Ser Ala Ser Ser Glu Ala Ala Ser Ala Val Val Ser Pro 
        275                 280                 285             


Ser Thr Asp Ser Gly Leu Glu Phe Ser Ser Gln Thr Thr Ser Lys Glu 
    290                 295                 300                 


Asp Leu Thr Asp Leu Glu Gln Pro Gly Ser Pro Gly Tyr Ser Thr Ala 
305                 310                 315                 320 


Thr Glu Pro Gly Ser Ser Glu Leu Gly Val Pro Glu Gln Pro Asp Leu 
                325                 330                 335     


Gln Glu Gly Thr His Val Glu Lys Ser Gln Ser Ala Ser Val Glu Ser 
            340                 345                 350         


Ile Pro Glu Val Leu Glu Glu Cys Thr Ser Pro Ala Asp His Ser Asp 
        355                 360                 365             


Ser Ala Ser Val His Asp Met Asp Tyr Val Asn Pro Arg Gly Val Arg 
    370                 375                 380                 


Phe Thr Gln Ser Ser Gln Lys Glu Gly Thr Ala Leu Val Pro Tyr Gly 
385                 390                 395                 400 


Leu Pro Cys Ile Arg Glu Leu Phe Arg Phe Leu Ile Ser Leu Thr Asn 
                405                 410                 415     


Pro His Asp Arg His Asn Ser Glu Val Met Ile His Met Gly Leu His 
            420                 425                 430         


Leu Leu Thr Val Ala Leu Glu Ser Ala Pro Val Ala Gln Cys Gln Thr 
        435                 440                 445             


Leu Leu Gly Leu Ile Lys Asp Glu Met Cys Arg His Leu Phe Gln Leu 
    450                 455                 460                 


Leu Ser Ile Glu Arg Leu Asn Leu Tyr Ala Ala Ser Leu Arg Val Cys 
465                 470                 475                 480 


Phe Leu Leu Phe Glu Ser Met Arg Glu His Leu Lys Phe Gln Met Glu 
                485                 490                 495     


Met Tyr Ile Lys Lys Leu Met Glu Ile Ile Thr Val Glu Asn Pro Lys 
            500                 505                 510         


Met Pro Tyr Glu Met Lys Glu Met Ala Leu Glu Ala Ile Val Gln Leu 
        515                 520                 525             


Trp Arg Ile Pro Ser Phe Val Thr Glu Leu Tyr Ile Asn Tyr Asp Cys 
    530                 535                 540                 


Asp Tyr Tyr Cys Ser Asn Leu Phe Glu Glu Leu Thr Lys Leu Leu Ser 
545                 550                 555                 560 


Lys Asn Ala Phe Pro Val Ser Gly Gln Leu Tyr Thr Thr His Leu Leu 
                565                 570                 575     


Ser Leu Asp Ala Leu Leu Thr Val Ile Asp Ser Thr Glu Ala His Cys 
            580                 585                 590         


Gln Ala Lys Val Leu Asn Ser Leu Thr Gln Gln Glu Lys Lys Glu Thr 
        595                 600                 605             


Ala Arg Pro Ser Cys Glu Ile Val Asp Gly Thr Arg Glu Ala Ser Asn 
    610                 615                 620                 


Thr Glu Arg Thr Ala Ser Asp Gly Lys Ala Val Gly Met Ala Ser Asp 
625                 630                 635                 640 


Ile Pro Gly Leu His Leu Pro Gly Gly Gly Arg Leu Pro Pro Glu His 
                645                 650                 655     


Gly Lys Ser Gly Cys Ser Asp Leu Glu Glu Ala Val Asp Ser Gly Ala 
            660                 665                 670         


Asp Lys Lys Phe Ala Arg Lys Pro Pro Arg Phe Ser Cys Leu Leu Pro 
        675                 680                 685             


Asp Pro Arg Glu Leu Ile Glu Ile Lys Asn Lys Lys Lys Leu Leu Ile 
    690                 695                 700                 


Thr Gly Thr Glu Gln Phe Asn Gln Lys Pro Lys Lys Gly Ile Gln Phe 
705                 710                 715                 720 


Leu Gln Glu Lys Gly Leu Leu Thr Ile Pro Met Asp Asn Thr Glu Val 
                725                 730                 735     


Ala Gln Trp Leu Arg Glu Asn Pro Arg Leu Asp Lys Lys Met Ile Gly 
            740                 745                 750         


Glu Phe Val Ser Asp Arg Lys Asn Ile Asp Leu Leu Glu Ser Phe Val 
        755                 760                 765             


Ser Thr Phe Ser Phe Gln Gly Leu Arg Leu Asp Glu Ala Leu Arg Leu 
    770                 775                 780                 


Tyr Leu Glu Ala Phe Arg Leu Pro Gly Glu Ala Pro Val Ile Gln Arg 
785                 790                 795                 800 


Leu Leu Glu Ala Phe Thr Glu Arg Trp Met Asn Cys Asn Gly Ser Pro 
                805                 810                 815     


Phe Ala Asn Ser Asp Ala Cys Phe Ser Leu Ala Tyr Ala Val Ile Met 
            820                 825                 830         


Leu Asn Thr Asp Gln His Asn His Asn Val Arg Lys Gln Asn Ala Pro 
        835                 840                 845             


Met Thr Leu Glu Glu Phe Arg Lys Asn Leu Lys Gly Val Asn Gly Gly 
    850                 855                 860                 


Lys Asp Phe Glu Gln Asp Ile Leu Glu Asp Met Tyr His Ala Ile Lys 
865                 870                 875                 880 


Asn Glu Glu Ile Val Met Pro Glu Glu Gln Thr Gly Leu Val Arg Glu 
                885                 890                 895     


Asn Tyr Val Trp Asn Val Leu Leu His Arg Gly Ala Thr Pro Glu Gly 
            900                 905                 910         


Ile Phe Leu Arg Val Pro Thr Ala Ser Tyr Asp Leu Asp Leu Phe Thr 
        915                 920                 925             


Met Thr Trp Gly Pro Thr Ile Ala Ala Leu Ser Tyr Val Phe Asp Lys 
    930                 935                 940                 


Ser Leu Glu Glu Thr Ile Ile Gln Lys Ala Ile Ser Gly Phe Arg Lys 
945                 950                 955                 960 


Cys Ala Met Ile Ser Ala His Tyr Gly Leu Ser Asp Val Phe Asp Asn 
                965                 970                 975     


Leu Ile Ile Ser Leu Cys Lys Phe Thr Ala Leu Ser Ser Glu Ser Ile 
            980                 985                 990         


Glu Asn Leu Pro Ser Val Phe Gly  Ser Asn Pro Lys Ala  His Ile Ala 
        995                 1000                 1005             


Ala Lys  Thr Val Phe His Leu  Ala His Arg His Gly  Asp Ile Leu 
    1010                 1015                 1020             


Arg Glu  Gly Trp Lys Asn Ile  Met Glu Ala Met Leu  Gln Leu Phe 
    1025                 1030                 1035             


Arg Ala  Gln Leu Leu Pro Lys  Ala Met Ile Glu Val  Glu Asp Phe 
    1040                 1045                 1050             


Val Asp  Pro Asn Gly Lys Ile  Ser Leu Gln Arg Glu  Glu Thr Pro 
    1055                 1060                 1065             


Ser Asn  Arg Gly Glu Ser Thr  Val Leu Ser Phe Val  Ser Trp Leu 
    1070                 1075                 1080             


Thr Leu  Ser Gly Pro Glu Gln  Ser Ser Val Arg Gly  Pro Ser Thr 
    1085                 1090                 1095             


Glu Asn  Gln Glu Ala Lys Arg  Val Ala Leu Glu Cys  Ile Lys Gln 
    1100                 1105                 1110             


Cys Asp  Pro Glu Lys Met Ile  Thr Glu Ser Lys Phe  Leu Gln Leu 
    1115                 1120                 1125             


Glu Ser  Leu Gln Glu Leu Met  Lys Ala Leu Val Ser  Val Thr Pro 
    1130                 1135                 1140             


Asp Glu  Glu Thr Tyr Asp Glu  Glu Asp Ala Ala Phe  Cys Leu Glu 
    1145                 1150                 1155             


Met Leu  Leu Arg Ile Val Leu  Glu Asn Arg Asp Arg  Val Gly Cys 
    1160                 1165                 1170             


Val Trp  Gln Thr Val Arg Asp  His Leu Tyr His Leu  Cys Val Gln 
    1175                 1180                 1185             


Ala Gln  Asp Phe Cys Phe Leu  Val Glu Arg Ala Val  Val Gly Leu 
    1190                 1195                 1200             


Leu Arg  Leu Ala Ile Arg Leu  Leu Arg Arg Glu Glu  Ile Ser Ala 
    1205                 1210                 1215             


Gln Val  Leu Leu Ser Leu Arg  Ile Leu Leu Leu Met  Lys Pro Ser 
    1220                 1225                 1230             


Val Leu  Ser Arg Val Ser His  Gln Val Ala Tyr Gly  Leu His Glu 
    1235                 1240                 1245             


Leu Leu  Lys Thr Asn Ala Ala  Asn Ile His Ser Gly  Asp Asp Trp 
    1250                 1255                 1260             


Ala Thr  Leu Phe Thr Leu Leu  Glu Cys Ile Gly Ser  Gly Val Lys 
    1265                 1270                 1275             


Pro Pro  Ala Ala Leu Gln Ala  Thr Ala Arg Ala Asp  Ala Pro Asp 
    1280                 1285                 1290             


Ala Gly  Ala Gln Ser Asp Ser  Glu Leu Pro Ser Tyr  His Gln Asn 
    1295                 1300                 1305             


Asp Val  Ser Leu Asp Arg Gly  Tyr Thr Ser Asp Ser  Glu Val Tyr 
    1310                 1315                 1320             


Thr Asp  His Gly Arg Pro Gly  Lys Ile His Arg Ser  Ala Thr Asp 
    1325                 1330                 1335             


Ala Asp  Val Val Asn Ser Gly  Trp Leu Val Val Gly  Lys Asp Asp 
    1340                 1345                 1350             


Val Asp  Asn Ser Lys Pro Gly  Pro Ser Arg Pro Gly  Pro Ser Pro 
    1355                 1360                 1365             


Leu Ile  Asn Gln Tyr Ser Leu  Thr Val Gly Leu Asp  Leu Gly Pro 
    1370                 1375                 1380             


His Asp  Thr Lys Ser Leu Leu  Lys Cys Val Glu Ser  Leu Ser Phe 
    1385                 1390                 1395             


Ile Val  Arg Asp Ala Ala His  Ile Thr Pro Asp Asn  Phe Glu Leu 
    1400                 1405                 1410             


Cys Val  Lys Thr Leu Arg Ile  Phe Val Glu Ala Ser  Leu Asn Gly 
    1415                 1420                 1425             


Gly Cys  Lys Ser Gln Glu Lys  Arg Gly Lys Ser His  Lys Tyr Asp 
    1430                 1435                 1440             


Ser Lys  Gly Asn Arg Phe Lys  Lys Lys Ser Lys Glu  Gly Ser Met 
    1445                 1450                 1455             


Leu Arg  Arg Pro Arg Thr Ser  Ser Gln His Ala Ser  Arg Gly Gly 
    1460                 1465                 1470             


Gln Ser  Asp Asp Asp Glu Asp  Glu Gly Val Pro Ala  Ser Tyr His 
    1475                 1480                 1485             


Thr Val  Ser Leu Gln Val Ser  Gln Asp Leu Leu Asp  Leu Met His 
    1490                 1495                 1500             


Thr Leu  His Thr Arg Ala Ala  Ser Ile Tyr Ser Ser  Trp Ala Glu 
    1505                 1510                 1515             


Glu Gln  Arg His Leu Glu Thr  Gly Gly Gln Lys Ile  Glu Ala Asp 
    1520                 1525                 1530             


Ser Arg  Thr Leu Trp Ala His  Cys Trp Cys Pro Leu  Leu Gln Gly 
    1535                 1540                 1545             


Ile Ala  Cys Leu Cys Cys Asp  Ala Arg Arg Gln Val  Arg Met Gln 
    1550                 1555                 1560             


Ala Leu  Thr Tyr Leu Gln Arg  Ala Leu Leu Val His  Asp Leu Gln 
    1565                 1570                 1575             


Lys Leu  Asp Ala Leu Glu Trp  Glu Ser Cys Phe Asn  Lys Val Leu 
    1580                 1585                 1590             


Phe Pro  Leu Leu Thr Lys Leu  Leu Glu Asn Ile Ser  Pro Ala Asp 
    1595                 1600                 1605             


Val Gly  Gly Met Glu Glu Thr  Arg Met Arg Ala Ser  Thr Leu Leu 
    1610                 1615                 1620             


Ser Lys  Val Phe Leu Gln His  Leu Ser Pro Leu Leu  Ser Leu Ser 
    1625                 1630                 1635             


Thr Phe  Ala Ala Leu Trp Leu  Thr Ile Leu Asp Phe  Met Asp Lys 
    1640                 1645                 1650             


Tyr Met  His Ala Gly Ser Ser  Asp Leu Leu Ser Glu  Ala Ile Pro 
    1655                 1660                 1665             


Glu Ser  Leu Lys Asn Met Leu  Leu Val Met Asp Thr  Ala Glu Ile 
    1670                 1675                 1680             


Phe His  Ser Ala Asp Ala Arg  Gly Gly Gly Pro Ser  Ala Leu Trp 
    1685                 1690                 1695             


Glu Ile  Thr Trp Glu Arg Ile  Asp Cys Phe Leu Pro  His Leu Arg 
    1700                 1705                 1710             


Asp Glu  Leu Phe Lys Gln Thr  Val Ile Gln Asp Pro  Met Pro Met 
    1715                 1720                 1725             


Glu Pro  Gln Gly Gln Lys Pro  Leu Ala Ser Ala His  Leu Thr Ser 
    1730                 1735                 1740             


Ala Ala  Gly Asp Thr Arg Thr  Pro Gly His Pro Pro  Pro Pro Glu 
    1745                 1750                 1755             


Ile Pro  Ser Glu Leu Gly Ala  Cys Asp Phe Glu Lys  Pro Glu Ser 
    1760                 1765                 1770             


Pro Arg  Ala Ala Ser Ser Ser  Ser Pro Gly Ser Pro  Val Ala Ser 
    1775                 1780                 1785             


Ser Pro  Ser Arg Leu Ser Pro  Thr Pro Asp Gly Pro  Pro Pro Leu 
    1790                 1795                 1800             


Ala Gln  Pro Pro Leu Ile Leu  Gln Pro Leu Ala Ser  Pro Leu Gln 
    1805                 1810                 1815             


Val Gly  Val Pro Pro Met Thr  Leu Pro Ile Ile Leu  Asn Pro Ala 
    1820                 1825                 1830             


Leu Ile  Glu Ala Thr Ser Pro  Val Pro Leu Leu Ala  Thr Pro Arg 
    1835                 1840                 1845             


Pro Thr  Asp Pro Ile Pro Thr  Ser Glu Val Asn 
    1850                 1855                 


<210>  9
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Thr Asp Ile Gln Val Ser Glu Ala Glu Lys Gly Ser Gly Arg Leu 
1               5                   10                  15      


Asn Asp Leu Pro Lys His Ser Asn Ala Gly Ile Leu Phe Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Asn Ile Phe Val Gly His Ile Gly Ile Ser Trp Ala Gly 
        35                  40                  45              


Ser His Ser Gly Pro Leu Ser Trp Phe Pro Gly Gly Leu Cys Thr Ser 
    50                  55                  60                  


Asn Leu Gly Ala Ser Phe Pro Pro Leu Gln Ser Pro Thr Met Ser Ala 
65                  70                  75                  80  


Asn Ala Thr Leu Lys Pro Leu Cys Pro Ile Leu Glu Gln Met Ser Arg 
                85                  90                  95      


Leu Gln Ser His Ser Asn Thr Ser Ile Arg Tyr Ile Asp His Ala Ala 
            100                 105                 110         


Val Leu Leu His Gly Leu Ala Ser Leu Leu Gly Leu Val Glu Asn Gly 
        115                 120                 125             


Val Ile Leu Phe Val Val Gly Cys Arg Met Arg Gln Thr Val Val Thr 
    130                 135                 140                 


Thr Trp Val Leu His Leu Ala Leu Ser Asp Leu Leu Ala Ser Ala Ser 
145                 150                 155                 160 


Leu Pro Phe Phe Thr Tyr Phe Leu Ala Val Gly His Ser Trp Glu Leu 
                165                 170                 175     


Gly Thr Thr Phe Cys Lys Leu His Ser Ser Ile Phe Phe Leu Asn Met 
            180                 185                 190         


Phe Ala Ser Gly Phe Leu Leu Ser Ala Ile Ser Leu Asp Arg Cys Leu 
        195                 200                 205             


Gln Val Val Arg Pro Val Trp Ala Gln Asn His Arg Thr Val Ala Ala 
    210                 215                 220                 


Ala His Lys Val Cys Leu Val Leu Trp Ala Leu Ala Val Leu Asn Thr 
225                 230                 235                 240 


Val Pro Tyr Phe Val Phe Arg Asp Thr Ile Ser Arg Leu Asp Gly Arg 
                245                 250                 255     


Ile Met Cys Tyr Tyr Asn Val Leu Leu Leu Asn Pro Gly Pro Asp Arg 
            260                 265                 270         


Asp Ala Thr Cys Asn Ser Arg Gln Ala Ala Leu Ala Val Ser Lys Phe 
        275                 280                 285             


Leu Leu Ala Phe Leu Val Pro Leu Ala Ile Ile Ala Ser Ser His Ala 
    290                 295                 300                 


Ala Val Ser Leu Arg Leu Gln His Arg Gly Arg Arg Arg Pro Gly Arg 
305                 310                 315                 320 


Phe Val Arg Leu Val Ala Ala Val Val Ala Ala Phe Ala Leu Cys Trp 
                325                 330                 335     


Gly Pro Tyr His Val Phe Ser Leu Leu Glu Ala Arg Ala His Ala Asn 
            340                 345                 350         


Pro Gly Leu Arg Pro Leu Val Trp Arg Gly Leu Pro Phe Val Thr Ser 
        355                 360                 365             


Leu Ala Phe Phe Asn Ser Val Ala Asn Pro Val Leu Tyr Val Leu Thr 
    370                 375                 380                 


Cys Pro Asp Met Leu Arg Lys Leu Arg Arg Ser Leu Arg Thr Val Leu 
385                 390                 395                 400 


Glu Ser Val Leu Val Asp Asp Ser Glu Leu Gly Gly Ala Gly Ser Ser 
                405                 410                 415     


Arg Arg Arg Arg Thr Ser Ser Thr Ala Arg Ser Ala Ser Pro Leu Ala 
            420                 425                 430         


Leu Cys Ser Arg Pro Glu Glu Pro Arg Gly Pro Ala Arg Leu Leu Gly 
        435                 440                 445             


Trp Leu Leu Val Gln Leu Arg Ser Val Pro Ala Asp Gly Pro Pro Glu 
    450                 455                 460                 


Pro Gly Ala Glu Gln His Leu Glu Leu Glu Pro Gly Pro Arg Arg Ala 
465                 470                 475                 480 


Ala Leu Thr Arg Glu Ser Ile Thr Arg Val Pro Arg Phe Asn Ser Ile 
                485                 490                 495     


Ser Gly Leu Leu Pro Gln 
            500         


<210>  10
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Asp Ser Leu Ala Thr Ser Ile Asn Gln Phe Ala Leu Glu Leu Ser 
1               5                   10                  15      


Lys Lys Leu Ala Glu Ser Ala Gln Gly Lys Asn Ile Phe Phe Ser Ser 
            20                  25                  30          


Trp Ser Ile Ser Thr Ser Leu Thr Ile Val Tyr Leu Gly Ala Lys Gly 
        35                  40                  45              


Thr Thr Ala Ala Gln Met Ala Gln Val Leu Gln Phe Asn Arg Asp Gln 
    50                  55                  60                  


Gly Val Lys Cys Asp Pro Glu Ser Glu Lys Lys Arg Lys Met Glu Phe 
65                  70                  75                  80  


Asn Leu Ser Asn Ser Glu Glu Ile His Ser Asp Phe Gln Thr Leu Ile 
                85                  90                  95      


Ser Glu Ile Leu Lys Pro Asn Asp Asp Tyr Leu Leu Lys Thr Ala Asn 
            100                 105                 110         


Ala Ile Tyr Gly Glu Lys Thr Tyr Ala Phe His Asn Lys Tyr Leu Glu 
        115                 120                 125             


Asp Met Lys Thr Tyr Phe Gly Ala Glu Pro Gln Pro Val Asn Phe Val 
    130                 135                 140                 


Glu Ala Ser Asp Gln Ile Arg Lys Asp Ile Asn Ser Trp Val Glu Arg 
145                 150                 155                 160 


Gln Thr Glu Gly Lys Ile Gln Asn Leu Leu Pro Asp Asp Ser Val Asp 
                165                 170                 175     


Ser Thr Thr Arg Met Ile Leu Val Asn Ala Leu Tyr Phe Lys Gly Ile 
            180                 185                 190         


Trp Glu His Gln Phe Leu Val Gln Asn Thr Thr Glu Lys Pro Phe Arg 
        195                 200                 205             


Ile Asn Glu Thr Thr Ser Lys Pro Val Gln Met Met Phe Met Lys Lys 
    210                 215                 220                 


Lys Leu His Ile Phe His Ile Glu Lys Pro Lys Ala Val Gly Leu Gln 
225                 230                 235                 240 


Leu Tyr Tyr Lys Ser Arg Asp Leu Ser Leu Leu Ile Leu Leu Pro Glu 
                245                 250                 255     


Asp Ile Asn Gly Leu Glu Gln Leu Glu Lys Ala Ile Thr Tyr Glu Lys 
            260                 265                 270         


Leu Asn Glu Trp Thr Ser Ala Asp Met Met Glu Leu Tyr Glu Val Gln 
        275                 280                 285             


Leu His Leu Pro Lys Phe Lys Leu Glu Asp Ser Tyr Asp Leu Lys Ser 
    290                 295                 300                 


Thr Leu Ser Ser Met Gly Met Ser Asp Ala Phe Ser Gln Ser Lys Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Met Ser Ser Ala Arg Asn Leu Phe Leu Ser Asn Val 
                325                 330                 335     


Phe His Lys Ala Phe Val Glu Ile Asn Glu Gln Gly Thr Glu Ala Ala 
            340                 345                 350         


Ala Gly Ser Gly Ser Glu Ile Asp Ile Arg Ile Arg Val Pro Ser Ile 
        355                 360                 365             


Glu Phe Asn Ala Asn His Pro Phe Leu Phe Phe Ile Arg His Asn Lys 
    370                 375                 380                 


Thr Asn Thr Ile Leu Phe Tyr Gly Arg Leu Cys Ser Pro 
385                 390                 395         


<210>  11
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Thr Gly Leu Ser Met Asp Gly Gly Gly Ser Pro Lys Gly Asp Val 
1               5                   10                  15      


Asp Pro Phe Tyr Tyr Asp Tyr Glu Thr Val Arg Asn Gly Gly Leu Ile 
            20                  25                  30          


Phe Ala Gly Leu Ala Phe Ile Val Gly Leu Leu Ile Leu Leu Ser Arg 
        35                  40                  45              


Arg Phe Arg Cys Gly Gly Asn Lys Lys Arg Arg Gln Ile Asn Glu Asp 
    50                  55                  60                  


Glu Pro 
65      


<210>  12
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Ala Ser Arg Arg Met Glu Thr Lys Pro Val Ile Thr Cys Leu Lys 
1               5                   10                  15      


Thr Leu Leu Ile Ile Tyr Ser Phe Val Phe Trp Ile Thr Gly Val Ile 
            20                  25                  30          


Leu Leu Ala Val Gly Val Trp Gly Lys Leu Thr Leu Gly Thr Tyr Ile 
        35                  40                  45              


Ser Leu Ile Ala Glu Asn Ser Thr Asn Ala Pro Tyr Val Leu Ile Gly 
    50                  55                  60                  


Thr Gly Thr Thr Ile Val Val Phe Gly Leu Phe Gly Cys Phe Ala Thr 
65                  70                  75                  80  


Cys Arg Gly Ser Pro Trp Met Leu Lys Leu Tyr Ala Met Phe Leu Ser 
                85                  90                  95      


Leu Val Phe Leu Ala Glu Leu Val Ala Gly Ile Ser Gly Phe Val Phe 
            100                 105                 110         


Arg His Glu Ile Lys Asp Thr Phe Leu Arg Thr Tyr Thr Asp Ala Met 
        115                 120                 125             


Gln Thr Tyr Asn Gly Asn Asp Glu Arg Ser Arg Ala Val Asp His Val 
    130                 135                 140                 


Gln Arg Ser Leu Ser Cys Cys Gly Val Gln Asn Tyr Thr Asn Trp Ser 
145                 150                 155                 160 


Thr Ser Pro Tyr Phe Leu Glu His Gly Ile Pro Pro Ser Cys Cys Met 
                165                 170                 175     


Asn Glu Thr Asp Cys Asn Pro Gln Asp Leu His Asn Leu Thr Val Ala 
            180                 185                 190         


Ala Thr Lys Val Asn Gln Lys Gly Cys Tyr Asp Leu Val Thr Ser Phe 
        195                 200                 205             


Met Glu Thr Asn Met Gly Ile Ile Ala Gly Val Ala Phe Gly Ile Ala 
    210                 215                 220                 


Phe Ser Gln Leu Ile Gly Met Leu Leu Ala Cys Cys Leu Ser Arg Phe 
225                 230                 235                 240 


Ile Thr Ala Asn Gln Tyr Glu Met Val 
                245                 


<210>  13
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Gly Glu Trp Thr Ile Leu Glu Arg Leu Leu Glu Ala Ala Val Gln 
1               5                   10                  15      


Gln His Ser Thr Met Ile Gly Arg Ile Leu Leu Thr Val Val Val Ile 
            20                  25                  30          


Phe Arg Ile Leu Ile Val Ala Ile Val Gly Glu Thr Val Tyr Asp Asp 
        35                  40                  45              


Glu Gln Thr Met Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Asn Gln 
    50                  55                  60                  


Ala Cys Tyr Asp Arg Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val 
65                  70                  75                  80  


Phe Gln Ile Ile Met Val Cys Thr Pro Ser Leu Cys Phe Ile Thr Tyr 
                85                  90                  95      


Ser Val His Gln Ser Ala Lys Gln Arg Glu Arg Arg Tyr Ser Thr Val 
            100                 105                 110         


Phe Leu Ala Leu Asp Arg Asp Pro Pro Glu Ser Ile Gly Gly Pro Gly 
        115                 120                 125             


Gly Thr Gly Gly Gly Gly Ser Gly Gly Gly Lys Arg Glu Asp Lys Lys 
    130                 135                 140                 


Leu Gln Asn Ala Ile Val Asn Gly Val Leu Gln Asn Thr Glu Asn Thr 
145                 150                 155                 160 


Ser Lys Glu Thr Glu Pro Asp Cys Leu Glu Val Lys Glu Leu Thr Pro 
                165                 170                 175     


His Pro Ser Gly Leu Arg Thr Ala Ser Lys Ser Lys Leu Arg Arg Gln 
            180                 185                 190         


Glu Gly Ile Ser Arg Phe Tyr Ile Ile Gln Val Val Phe Arg Asn Ala 
        195                 200                 205             


Leu Glu Ile Gly Phe Leu Val Gly Gln Tyr Phe Leu Tyr Gly Phe Ser 
    210                 215                 220                 


Val Pro Gly Leu Tyr Glu Cys Asn Arg Tyr Pro Cys Ile Lys Glu Val 
225                 230                 235                 240 


Glu Cys Tyr Val Ser Arg Pro Thr Glu Lys Thr Val Phe Leu Val Phe 
                245                 250                 255     


Met Phe Ala Val Ser Gly Ile Cys Val Val Leu Asn Leu Ala Glu Leu 
            260                 265                 270         


Asn His Leu Gly Trp Arg Lys Ile Lys Leu Ala Val Arg Gly Ala Gln 
        275                 280                 285             


Ala Lys Arg Lys Ser Ile Tyr Glu Ile Arg Asn Lys Asp Leu Pro Arg 
    290                 295                 300                 


Val Ser Val Pro Asn Phe Gly Arg Thr Gln Ser Ser Asp Ser Ala Tyr 
305                 310                 315                 320 


Val 
    


<210>  14
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Ala Leu Ser Glu Leu Ala Leu Val Arg Trp Leu Gln Glu Ser Arg 
1               5                   10                  15      


Arg Ser Arg Lys Leu Ile Leu Phe Ile Val Phe Leu Ala Leu Leu Leu 
            20                  25                  30          


Asp Asn Met Leu Leu Thr Val Val Val Pro Ile Ile Pro Ser Tyr Leu 
        35                  40                  45              


Tyr Ser Ile Lys His Glu Lys Asn Ala Thr Glu Ile Gln Thr Ala Arg 
    50                  55                  60                  


Pro Val His Thr Ala Ser Ile Ser Asp Ser Phe Gln Ser Ile Phe Ser 
65                  70                  75                  80  


Tyr Tyr Asp Asn Ser Thr Met Val Thr Gly Asn Ala Thr Arg Asp Leu 
                85                  90                  95      


Thr Leu His Gln Thr Ala Thr Gln His Met Val Thr Asn Ala Ser Ala 
            100                 105                 110         


Val Pro Ser Asp Cys Pro Ser Glu Asp Lys Asp Leu Leu Asn Glu Asn 
        115                 120                 125             


Val Gln Val Gly Leu Leu Phe Ala Ser Lys Ala Thr Val Gln Leu Ile 
    130                 135                 140                 


Thr Asn Pro Phe Ile Gly Leu Leu Thr Asn Arg Ile Gly Tyr Pro Ile 
145                 150                 155                 160 


Pro Ile Phe Ala Gly Phe Cys Ile Met Phe Val Ser Thr Ile Met Phe 
                165                 170                 175     


Ala Phe Ser Ser Ser Tyr Ala Phe Leu Leu Ile Ala Arg Ser Leu Gln 
            180                 185                 190         


Gly Ile Gly Ser Ser Cys Ser Ser Val Ala Gly Met Gly Met Leu Ala 
        195                 200                 205             


Ser Val Tyr Thr Asp Asp Glu Glu Arg Gly Asn Val Met Gly Ile Ala 
    210                 215                 220                 


Leu Gly Gly Leu Ala Met Gly Val Leu Val Gly Pro Pro Phe Gly Ser 
225                 230                 235                 240 


Val Leu Tyr Glu Phe Val Gly Lys Thr Ala Pro Phe Leu Val Leu Ala 
                245                 250                 255     


Ala Leu Val Leu Leu Asp Gly Ala Ile Gln Leu Phe Val Leu Gln Pro 
            260                 265                 270         


Ser Arg Val Gln Pro Glu Ser Gln Lys Gly Thr Pro Leu Thr Thr Leu 
        275                 280                 285             


Leu Lys Asp Pro Tyr Ile Leu Ile Ala Ala Gly Ser Ile Cys Phe Ala 
    290                 295                 300                 


Asn Met Gly Ile Ala Met Leu Glu Pro Ala Leu Pro Ile Trp Met Met 
305                 310                 315                 320 


Glu Thr Met Cys Ser Arg Lys Trp Gln Leu Gly Val Ala Phe Leu Pro 
                325                 330                 335     


Ala Ser Ile Ser Tyr Leu Ile Gly Thr Asn Ile Phe Gly Ile Leu Ala 
            340                 345                 350         


His Lys Met Gly Arg Trp Leu Cys Ala Leu Leu Gly Met Ile Ile Val 
        355                 360                 365             


Gly Val Ser Ile Leu Cys Ile Pro Phe Ala Lys Asn Ile Tyr Gly Leu 
    370                 375                 380                 


Ile Ala Pro Asn Phe Gly Val Gly Phe Ala Ile Gly Met Val Asp Ser 
385                 390                 395                 400 


Ser Met Met Pro Ile Met Gly Tyr Leu Val Asp Leu Arg His Val Ser 
                405                 410                 415     


Val Tyr Gly Ser Val Tyr Ala Ile Ala Asp Val Ala Phe Cys Met Gly 
            420                 425                 430         


Tyr Ala Ile Gly Pro Ser Ala Gly Gly Ala Ile Ala Lys Ala Ile Gly 
        435                 440                 445             


Phe Pro Trp Leu Met Thr Ile Ile Gly Ile Ile Asp Ile Leu Phe Ala 
    450                 455                 460                 


Pro Leu Cys Phe Phe Leu Arg Ser Pro Pro Ala Lys Glu Glu Lys Met 
465                 470                 475                 480 


Ala Ile Leu Met Asp His Asn Cys Pro Ile Lys Thr Lys Met Tyr Thr 
                485                 490                 495     


Gln Asn Asn Ile Gln Ser Tyr Pro Ile Gly Glu Asp Glu Glu Ser Glu 
            500                 505                 510         


Ser Asp 
        


<210>  15
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Glu Thr Thr Met Gly Phe Met Asp Asp Asn Ala Thr Asn Thr Ser 
1               5                   10                  15      


Thr Ser Phe Leu Ser Val Leu Asn Pro His Gly Ala His Ala Thr Ser 
            20                  25                  30          


Phe Pro Phe Asn Phe Ser Tyr Ser Asp Tyr Asp Met Pro Leu Asp Glu 
        35                  40                  45              


Asp Glu Asp Val Thr Asn Ser Arg Thr Phe Phe Ala Ala Lys Ile Val 
    50                  55                  60                  


Ile Gly Met Ala Leu Val Gly Ile Met Leu Val Cys Gly Ile Gly Asn 
65                  70                  75                  80  


Phe Ile Phe Ile Ala Ala Leu Val Arg Tyr Lys Lys Leu Arg Asn Leu 
                85                  90                  95      


Thr Asn Leu Leu Ile Ala Asn Leu Ala Ile Ser Asp Phe Leu Val Ala 
            100                 105                 110         


Ile Val Cys Cys Pro Phe Glu Met Asp Tyr Tyr Val Val Arg Gln Leu 
        115                 120                 125             


Ser Trp Glu His Gly His Val Leu Cys Thr Ser Val Asn Tyr Leu Arg 
    130                 135                 140                 


Thr Val Ser Leu Tyr Val Ser Thr Asn Ala Leu Leu Ala Ile Ala Ile 
145                 150                 155                 160 


Asp Arg Tyr Leu Ala Ile Val His Pro Leu Arg Pro Arg Met Lys Cys 
                165                 170                 175     


Gln Thr Ala Thr Gly Leu Ile Ala Leu Val Trp Thr Val Ser Ile Leu 
            180                 185                 190         


Ile Ala Ile Pro Ser Ala Tyr Phe Thr Thr Glu Thr Val Leu Val Ile 
        195                 200                 205             


Val Lys Ser Gln Glu Lys Ile Phe Cys Gly Gln Ile Trp Pro Val Asp 
    210                 215                 220                 


Gln Gln Leu Tyr Tyr Lys Ser Tyr Phe Leu Phe Ile Phe Gly Ile Glu 
225                 230                 235                 240 


Phe Val Gly Pro Val Val Thr Met Thr Leu Cys Tyr Ala Arg Ile Ser 
                245                 250                 255     


Arg Glu Leu Trp Phe Lys Ala Val Pro Gly Phe Gln Thr Glu Gln Ile 
            260                 265                 270         


Arg Lys Arg Leu Arg Cys Arg Arg Lys Thr Val Leu Val Leu Met Cys 
        275                 280                 285             


Ile Leu Thr Ala Tyr Val Leu Cys Trp Ala Pro Phe Tyr Gly Phe Thr 
    290                 295                 300                 


Ile Val Arg Asp Phe Phe Pro Thr Val Phe Val Lys Glu Lys His Tyr 
305                 310                 315                 320 


Leu Thr Ala Phe Tyr Ile Val Glu Cys Ile Ala Met Ser Asn Ser Met 
                325                 330                 335     


Ile Asn Thr Leu Cys Phe Val Thr Val Lys Asn Asp Thr Val Lys Tyr 
            340                 345                 350         


Phe Lys Lys Ile Met Leu Leu His Trp Lys Ala Ser Tyr Asn Gly Gly 
        355                 360                 365             


Lys Ser Ser Ala Asp Leu Asp Leu Lys Thr Ile Gly Met Pro Ala Thr 
    370                 375                 380                 


Glu Glu Val Asp Cys Ile Arg Leu Lys 
385                 390             


<210>  16
<211>  1212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Arg Tyr Lys Asp 
865                 870                 875                 880 


Arg Arg Leu Ala Gln His Lys Ser Glu Ile Glu Cys Phe Thr Pro Lys 
                885                 890                 895     


Gly Ser Met Gly Asn Gly Gly Arg Ala Thr Met Ser Ser Ser Asn Gly 
            900                 905                 910         


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
        915                 920                 925             


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
    930                 935                 940                 


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
945                 950                 955                 960 


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
                965                 970                 975     


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
            980                 985                 990         


Pro Asp Ala Gly Pro Lys Ala Leu  Tyr Asp Val Ala Glu  Ala Glu Glu 
        995                 1000                 1005             


His Phe  Pro Ala Pro Ala Arg  Pro Arg Ser Pro Ser  Pro Ile Ser 
    1010                 1015                 1020             


Thr Leu  Ser His Arg Ala Gly  Ser Ala Ser Arg Thr  Asp Asp Asp 
    1025                 1030                 1035             


Val Pro  Ser Leu His Ser Glu  Pro Val Ala Arg Ser  Ser Ser Ser 
    1040                 1045                 1050             


Gln Gly  Ser Leu Met Glu Gln  Ile Ser Ser Val Val  Thr Arg Phe 
    1055                 1060                 1065             


Thr Ala  Asn Ile Ser Glu Leu  Asn Ser Met Met Leu  Ser Thr Ala 
    1070                 1075                 1080             


Ala Pro  Ser Pro Gly Val Gly  Ala Pro Leu Cys Ser  Ser Tyr Leu 
    1085                 1090                 1095             


Ile Pro  Lys Glu Ile Gln Leu  Pro Thr Thr Met Thr  Thr Phe Ala 
    1100                 1105                 1110             


Glu Ile  Gln Pro Leu Pro Ala  Ile Glu Val Thr Gly  Gly Ala Gln 
    1115                 1120                 1125             


Pro Ala  Ala Gly Ala Gln Ala  Ala Gly Asp Ala Ala  Arg Glu Ser 
    1130                 1135                 1140             


Pro Ala  Ala Gly Pro Glu Ala  Ala Ala Ala Lys Pro  Asp Leu Glu 
    1145                 1150                 1155             


Glu Leu  Val Ala Leu Thr Pro  Pro Ser Pro Phe Arg  Asp Ser Val 
    1160                 1165                 1170             


Asp Ser  Gly Ser Thr Thr Pro  Asn Ser Pro Val Ser  Glu Ser Ala 
    1175                 1180                 1185             


Leu Cys  Ile Pro Ser Ser Pro  Lys Tyr Asp Thr Leu  Ile Ile Arg 
    1190                 1195                 1200             


Asp Tyr  Thr Gln Ser Ser Ser  Ser Leu 
    1205                 1210         


<210>  17
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Gly Pro Ile Gly Ala Glu Ala Asp Glu Asn Gln Thr Val Glu Glu 
1               5                   10                  15      


Met Lys Val Glu Gln Tyr Gly Pro Gln Thr Thr Pro Arg Gly Glu Leu 
            20                  25                  30          


Val Pro Asp Pro Glu Pro Glu Leu Ile Asp Ser Thr Lys Leu Ile Glu 
        35                  40                  45              


Val Gln Val Val Leu Ile Leu Ala Tyr Cys Ser Ile Ile Leu Leu Gly 
    50                  55                  60                  


Val Ile Gly Asn Ser Leu Val Ile His Val Val Ile Lys Phe Lys Ser 
65                  70                  75                  80  


Met Arg Thr Val Thr Asn Phe Phe Ile Ala Asn Leu Ala Val Ala Asp 
                85                  90                  95      


Leu Leu Val Asn Thr Leu Cys Leu Pro Phe Thr Leu Thr Tyr Thr Leu 
            100                 105                 110         


Met Gly Glu Trp Lys Met Gly Pro Val Leu Cys His Leu Val Pro Tyr 
        115                 120                 125             


Ala Gln Gly Leu Ala Val Gln Val Ser Thr Ile Thr Leu Thr Val Ile 
    130                 135                 140                 


Ala Leu Asp Arg His Arg Cys Ile Val Tyr His Leu Glu Ser Lys Ile 
145                 150                 155                 160 


Ser Lys Arg Ile Ser Phe Leu Ile Ile Gly Leu Ala Trp Gly Ile Ser 
                165                 170                 175     


Ala Leu Leu Ala Ser Pro Leu Ala Ile Phe Arg Glu Tyr Ser Leu Ile 
            180                 185                 190         


Glu Ile Ile Pro Asp Phe Glu Ile Val Ala Cys Thr Glu Lys Trp Pro 
        195                 200                 205             


Gly Glu Glu Lys Ser Ile Tyr Gly Thr Val Tyr Ser Leu Ser Ser Leu 
    210                 215                 220                 


Leu Ile Leu Tyr Val Leu Pro Leu Gly Ile Ile Ser Phe Ser Tyr Thr 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Leu Lys Asn His Val Ser Pro Gly Ala Ala Asn 
                245                 250                 255     


Asp His Tyr His Gln Arg Arg Gln Lys Thr Thr Lys Met Leu Val Cys 
            260                 265                 270         


Val Val Val Val Phe Ala Val Ser Trp Leu Pro Leu His Ala Phe Gln 
        275                 280                 285             


Leu Ala Val Asp Ile Asp Ser Gln Val Leu Asp Leu Lys Glu Tyr Lys 
    290                 295                 300                 


Leu Ile Phe Thr Val Phe His Ile Ile Ala Met Cys Ser Thr Phe Ala 
305                 310                 315                 320 


Asn Pro Leu Leu Tyr Gly Trp Met Asn Ser Asn Tyr Arg Lys Ala Phe 
                325                 330                 335     


Leu Ser Ala Phe Arg Cys Glu Gln Arg Leu Asp Ala Ile His Ser Glu 
            340                 345                 350         


Val Ser Val Thr Phe Lys Ala Lys Lys Asn Leu Glu Val Arg Lys Asn 
        355                 360                 365             


Ser Gly Pro Asn Asp Ser Phe Thr Glu Ala Thr Asn Val 
    370                 375                 380     


<210>  18
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Leu Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Ala Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser 
    450                 455                 460             


<210>  19
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Leu Trp Leu Leu Phe Phe Leu Val Thr Ala Ile His Ala Glu Leu 
1               5                   10                  15      


Cys Gln Pro Gly Ala Glu Asn Ala Phe Lys Val Arg Leu Ser Ile Arg 
            20                  25                  30          


Thr Ala Leu Gly Asp Lys Ala Tyr Ala Trp Asp Thr Asn Glu Glu Tyr 
        35                  40                  45              


Leu Phe Lys Ala Met Val Ala Phe Ser Met Arg Lys Val Pro Asn Arg 
    50                  55                  60                  


Glu Ala Thr Glu Ile Ser His Val Leu Leu Cys Asn Val Thr Gln Arg 
65                  70                  75                  80  


Val Ser Phe Trp Phe Val Val Thr Asp Pro Ser Lys Asn His Thr Leu 
                85                  90                  95      


Pro Ala Val Glu Val Gln Ser Ala Ile Arg Met Asn Lys Asn Arg Ile 
            100                 105                 110         


Asn Asn Ala Phe Phe Leu Asn Asp Gln Thr Leu Glu Phe Leu Lys Ile 
        115                 120                 125             


Pro Ser Thr Leu Ala Pro Pro Met Asp Pro Ser Val Pro Ile Trp Ile 
    130                 135                 140                 


Ile Ile Phe Gly Val Ile Phe Cys Ile Ile Ile Val Ala Ile Ala Leu 
145                 150                 155                 160 


Leu Ile Leu Ser Gly Ile Trp Gln Arg Arg Arg Lys Asn Lys Glu Pro 
                165                 170                 175     


Ser Glu Val Asp Asp Ala Glu Asp Lys Cys Glu Asn Met Ile Thr Ile 
            180                 185                 190         


Glu Asn Gly Ile Pro Ser Asp Pro Leu Asp Met Lys Gly Gly His Ile 
        195                 200                 205             


Asn Asp Ala Phe Met Thr Glu Asp Glu Arg Leu Thr Pro Leu 
    210                 215                 220         


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Arg Arg Ala Ser Ala Pro 
1               5       


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Leu Arg Arg Ala Ser Ala Pro 
1               5           


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Trp Leu Arg Arg Ala Ser Ala Pro 
1               5               


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Arg Arg Ala Thr Ala Pro 
1               5       


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Leu Arg Arg Ala Thr Ala Pro 
1               5           


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Trp Leu Arg Arg Ala Thr Ala Pro 
1               5               


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Arg Arg Ala Tyr Ala Pro 
1               5       


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Leu Arg Arg Ala Tyr Ala Pro 
1               5           


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Trp Leu Arg Arg Ala Tyr Ala Pro 
1               5               


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Arg Arg Ala Asp Ala Pro 
1               5       


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Leu Arg Arg Ala Asp Ala Pro 
1               5           


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Trp Leu Arg Arg Ala Asp Ala Pro 
1               5               


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Arg Arg Ala Glu Ala Pro 
1               5       


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Leu Arg Arg Ala Glu Ala Pro 
1               5           


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Trp Leu Arg Arg Ala Glu Ala Pro 
1               5               


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Arg Arg Ala Ser Ala Pro Arg Arg Ala Ser Ala Pro 
1               5                   10          


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Leu Arg Arg Ala Ser Ala Pro Leu Arg Arg Ala Ser Ala Pro 
1               5                   10                  


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Trp Leu Arg Arg Ala Ser Ala Pro Trp Leu Arg Arg Ala Ser Ala Pro 
1               5                   10                  15      


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Arg Arg Ala Thr Ala Pro Arg Arg Ala Thr Ala Pro 
1               5                   10          


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Leu Arg Arg Ala Thr Ala Pro Leu Arg Arg Ala Thr Ala Pro 
1               5                   10                  


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Trp Leu Arg Arg Ala Thr Ala Pro Trp Leu Arg Arg Ala Thr Ala Pro 
1               5                   10                  15      


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Arg Arg Ala Tyr Ala Pro Arg Arg Ala Tyr Ala Pro 
1               5                   10          


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Leu Arg Arg Ala Tyr Ala Pro Leu Arg Arg Ala Tyr Ala Pro 
1               5                   10                  


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Trp Leu Arg Arg Ala Tyr Ala Pro Trp Leu Arg Arg Ala Tyr Ala Pro 
1               5                   10                  15      


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Arg Arg Ala Asp Ala Pro Arg Arg Ala Asp Ala Pro 
1               5                   10          


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Leu Arg Arg Ala Asp Ala Pro Leu Arg Arg Ala Asp Ala Pro 
1               5                   10                  


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Trp Leu Arg Arg Ala Asp Ala Pro Trp Leu Arg Arg Ala Asp Ala Pro 
1               5                   10                  15      


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Arg Arg Ala Glu Ala Pro Arg Arg Ala Glu Ala Pro 
1               5                   10          


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Leu Arg Arg Ala Glu Ala Pro Leu Arg Arg Ala Glu Ala Pro 
1               5                   10                  


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Trp Leu Arg Arg Ala Glu Ala Pro Trp Leu Arg Arg Ala Glu Ala Pro 
1               5                   10                  15      


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Ala Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10          


<210>  52
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Asp Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Glu 
        


<210>  53
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Leu Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Pro Leu Ser Ser Ile Ser Arg Ile Gly Asp Pro 
1               5                   10      


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Ala Ala Val Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10          


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Val Thr Val Leu Ala Leu Gly Ala Leu Ala Gly Val Gly Val Gly 
1               5                   10                  15  


<210>  58
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro 
            20      


<210>  59
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Leu Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  61
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Lys Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  63
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Lys Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Ala Ala Gly Cys 
1               5                   10                  15      


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Ala Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Lys Ala Phe Ala Ala Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  66
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Lys Ala Phe Ala Lys Leu Ala Ala Gln Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Ala Gly Gly Gly Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10                  15      


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
ggaggggtga agacatgaga                                                   20


<210>  71
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
tctgaagtga ttgtccatcc ag                                                22


<210>  72
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Met Asp Arg Trp Tyr Leu Gly Gly Ser Pro Lys Gly Asp Val Asp Pro 
1               5                   10                  15      


Phe Tyr Tyr Asp Tyr Glu Thr Val Arg Asn Gly Gly Leu Ile Phe Ala 
            20                  25                  30          


Gly Leu Ala Phe Ile Val Gly Leu Leu Ile Leu Leu Ser Arg Arg Phe 
        35                  40                  45              


Arg Cys Gly Gly Asn Lys Lys Arg Arg Gln Ile Asn Glu Asp Glu Pro 
    50                  55                  60                  


<210>  73
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Gly 
        35          


<210>  74
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  75
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
65                  70                  75                  80  


Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala 
                85                  90                  95      


Val Ala Ala 
            


<210>  76
<211>  533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
tgctcagttc atccctagag gcagctgctc caggaacaga ggtgccatgc agccccgggt       60

actccttgtt gttgccctcc tggcgctcct ggcctctgcc cgagcttcag aggccgagga      120

tgcctccctt ctcagcttca tgcagggtta catgaagcac gccaccaaga ccgccaagga      180

tgcactgagc agcgtgcagg agtcccaggt ggcccagcag gccaggggct gggtgaccga      240

tggcttcagt tccctgaaag actactggag caccgttaag gacaagttct ctgagttctg      300

ggatttggac cctgaggtca gaccaacttc agccgtggct gcctgagacc tcaatacccc      360

aagtccacct gcctatccat cctgcgagct ccttgggtcc tgcaatctcc agggctgccc      420

ctgtaggttg cttaaaaggg acagtattct cagtgctctc ctaccccacc tcatgcctgg      480

cccccctcca ggcatgctgg cctcccaata aagctggaca agaagctgct atg             533


