                         SEQUENCE LISTING

<110>  UNIVERSITE DE GENEVE
 
<120>  METHODS FOR INDUCING INSULIN PRODUCTION AND USES THEREOF

<130>  P1527PC00

<150>  US 61/787,054
<151>  2013-03-15

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  284
<212>  PRT
<213>  Mus musculus

<400>  1

Met Asn Ser Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Val Pro Glu Phe Ser Ala Asn Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Gln Phe Thr Ser Ser Leu Gly Ser Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Ser Asp Asp Pro Ala Gly 
65                  70                  75                  80  


Ala His Leu His His His Leu Pro Ala Gln Leu Gly Leu Ala His Pro 
                85                  90                  95      


Pro Pro Gly Pro Phe Pro Asn Gly Thr Glu Pro Gly Gly Leu Glu Glu 
            100                 105                 110         


Pro Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala 
        115                 120                 125             


His Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Thr Ala Glu Pro 
    130                 135                 140                 


Glu Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu 
145                 150                 155                 160 


Glu Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg 
                165                 170                 175     


Arg Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys 
            180                 185                 190         


Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys 
        195                 200                 205             


Lys Arg Ser Ser Gly Thr Pro Ser Gly Gly Gly Gly Gly Glu Glu Pro 
    210                 215                 220                 


Glu Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Val Pro 
225                 230                 235                 240 


Pro Leu Pro Pro Pro Gly Gly Ala Val Pro Pro Gly Val Pro Ala Ala 
                245                 250                 255     


Val Arg Glu Gly Leu Leu Pro Ser Gly Leu Ser Val Ser Pro Gln Pro 
            260                 265                 270         


Ser Ser Ile Ala Pro Leu Arg Pro Gln Glu Pro Arg 
        275                 280                 


<210>  2
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Leu His His His Leu Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro Pro Ala Ala Pro Val Ala Ala 
                245                 250                 255     


Arg Glu Gly Arg Leu Pro Pro Gly Leu Ser Ala Ser Pro Gln Pro Ser 
            260                 265                 270         


Ser Val Ala Pro Arg Arg Pro Gln Glu Pro Arg 
        275                 280             


<210>  3
<211>  365
<212>  PRT
<213>  Mus musculus

<400>  3

Met Leu Ala Val Gly Ala Met Glu Gly Pro Arg Gln Ser Ala Phe Leu 
1               5                   10                  15      


Leu Ser Ser Pro Pro Leu Ala Ala Leu His Ser Met Ala Glu Met Lys 
            20                  25                  30          


Thr Pro Leu Tyr Pro Ala Ala Tyr Pro Pro Leu Pro Thr Gly Pro Pro 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Pro Pro Leu 
    50                  55                  60                  


Gly Ser His Asn Pro Gly Gly Leu Lys Pro Pro Ala Ala Gly Gly Leu 
65                  70                  75                  80  


Ser Ser Leu Gly Ser Pro Pro Gln Gln Leu Ser Ala Ala Thr Pro His 
                85                  90                  95      


Gly Ile Asn Asp Ile Leu Ser Arg Pro Ser Met Pro Val Ala Ser Gly 
            100                 105                 110         


Ala Ala Leu Pro Ser Ala Ser Pro Ser Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Ser Ser Ala Ser Ala Thr Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Ala Gly Leu Leu Ala Gly 
145                 150                 155                 160 


Leu Pro Arg Phe Ser Ser Leu Ser Pro Pro Pro Pro Pro Pro Gly Leu 
                165                 170                 175     


Tyr Phe Ser Pro Ser Ala Ala Ala Val Ala Ala Val Gly Arg Tyr Pro 
            180                 185                 190         


Lys Pro Leu Ala Glu Leu Pro Gly Arg Thr Pro Ile Phe Trp Pro Gly 
        195                 200                 205             


Val Met Gln Ser Pro Pro Trp Arg Asp Ala Arg Leu Ala Cys Thr Pro 
    210                 215                 220                 


His Gln Gly Ser Ile Leu Leu Asp Lys Asp Gly Lys Arg Lys His Thr 
225                 230                 235                 240 


Arg Pro Thr Phe Ser Gly Gln Gln Ile Phe Ala Leu Glu Lys Thr Phe 
                245                 250                 255     


Glu Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala Arg Leu Ala Tyr 
            260                 265                 270         


Ser Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp Phe Gln Asn Arg 
        275                 280                 285             


Arg Thr Lys Trp Arg Lys Lys His Ala Ala Glu Met Ala Thr Ala Lys 
    290                 295                 300                 


Lys Lys Gln Asp Ser Glu Thr Glu Arg Leu Lys Gly Thr Ser Glu Asn 
305                 310                 315                 320 


Glu Glu Asp Asp Asp Asp Tyr Asn Lys Pro Leu Asp Pro Asn Ser Asp 
                325                 330                 335     


Asp Glu Lys Ile Thr Gln Leu Leu Lys Lys His Lys Ser Ser Gly Gly 
            340                 345                 350         


Ser Leu Leu Leu His Ala Ser Glu Ala Glu Gly Ser Ser 
        355                 360                 365 


<210>  4
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Ala Val Gly Ala Met Glu Gly Thr Arg Gln Ser Ala Phe Leu 
1               5                   10                  15      


Leu Ser Ser Pro Pro Leu Ala Ala Leu His Ser Met Ala Glu Met Lys 
            20                  25                  30          


Thr Pro Leu Tyr Pro Ala Ala Tyr Pro Pro Leu Pro Ala Gly Pro Pro 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Pro Pro Leu 
    50                  55                  60                  


Gly Thr His Asn Pro Gly Gly Leu Lys Pro Pro Ala Thr Gly Gly Leu 
65                  70                  75                  80  


Ser Ser Leu Gly Ser Pro Pro Gln Gln Leu Ser Ala Ala Thr Pro His 
                85                  90                  95      


Gly Ile Asn Asp Ile Leu Ser Arg Pro Ser Met Pro Val Ala Ser Gly 
            100                 105                 110         


Ala Ala Leu Pro Ser Ala Ser Pro Ser Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Ser Ser Ala Ser Ala Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ser Ser Pro Ala Gly Leu Leu Ala Gly Leu 
145                 150                 155                 160 


Pro Arg Phe Ser Ser Leu Ser Pro Pro Pro Pro Pro Pro Gly Leu Tyr 
                165                 170                 175     


Phe Ser Pro Ser Ala Ala Ala Val Ala Ala Val Gly Arg Tyr Pro Lys 
            180                 185                 190         


Pro Leu Ala Glu Leu Pro Gly Arg Thr Pro Ile Phe Trp Pro Gly Val 
        195                 200                 205             


Met Gln Ser Pro Pro Trp Arg Asp Ala Arg Leu Ala Cys Thr Pro His 
    210                 215                 220                 


Gln Gly Ser Ile Leu Leu Asp Lys Asp Gly Lys Arg Lys His Thr Arg 
225                 230                 235                 240 


Pro Thr Phe Ser Gly Gln Gln Ile Phe Ala Leu Glu Lys Thr Phe Glu 
                245                 250                 255     


Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala Arg Leu Ala Tyr Ser 
            260                 265                 270         


Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp Phe Gln Asn Arg Arg 
        275                 280                 285             


Thr Lys Trp Arg Lys Lys His Ala Ala Glu Met Ala Thr Ala Lys Lys 
    290                 295                 300                 


Lys Gln Asp Ser Glu Thr Glu Arg Leu Lys Gly Ala Ser Glu Asn Glu 
305                 310                 315                 320 


Glu Glu Asp Asp Asp Tyr Asn Lys Pro Leu Asp Pro Asn Ser Asp Asp 
                325                 330                 335     


Glu Lys Ile Thr Gln Leu Leu Lys Lys His Lys Ser Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Gly Leu Leu Leu His Ala Ser Glu Pro Glu Ser Ser Ser 
        355                 360                 365         


<210>  5
<211>  273
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ser Leu Thr Asn Thr Lys Thr Gly Phe Ser Val Lys Asp Ile Leu 
1               5                   10                  15      


Asp Leu Pro Asp Thr Asn Asp Glu Asp Gly Ser Val Ala Glu Gly Pro 
            20                  25                  30          


Glu Glu Glu Ser Glu Gly Pro Glu Pro Ala Lys Arg Ala Gly Pro Leu 
        35                  40                  45              


Gly Gln Gly Ala Leu Asp Ala Val Gln Ser Leu Pro Leu Lys Ser Pro 
    50                  55                  60                  


Phe Tyr Asp Ser Ser Asp Asn Pro Tyr Thr Arg Trp Leu Ala Ser Thr 
65                  70                  75                  80  


Glu Gly Leu Gln Tyr Ser Leu His Gly Leu Ala Ala Ser Ala Pro Pro 
                85                  90                  95      


Gln Asp Ser Ser Ser Lys Ser Pro Glu Pro Ser Ala Asp Glu Ser Pro 
            100                 105                 110         


Asp Asn Asp Lys Glu Thr Gln Gly Gly Gly Gly Asp Ala Gly Lys Lys 
        115                 120                 125             


Arg Lys Arg Arg Val Leu Phe Ser Lys Ala Gln Thr Tyr Glu Leu Glu 
    130                 135                 140                 


Arg Arg Phe Arg Gln Gln Arg Tyr Leu Ser Ala Pro Glu Arg Glu His 
145                 150                 155                 160 


Leu Ala Ser Leu Ile Arg Leu Thr Pro Thr Gln Val Lys Ile Trp Phe 
                165                 170                 175     


Gln Asn His Arg Tyr Lys Met Lys Arg Ala Arg Ala Glu Lys Gly Met 
            180                 185                 190         


Glu Val Thr Pro Leu Pro Ser Pro Arg Arg Val Ala Val Pro Val Leu 
        195                 200                 205             


Val Arg Asp Gly Lys Pro Cys His Ala Leu Lys Ala Gln Asp Leu Ala 
    210                 215                 220                 


Ala Ala Thr Phe Gln Ala Gly Ile Pro Phe Ser Ala Tyr Ser Ala Gln 
225                 230                 235                 240 


Ser Leu Gln His Met Gln Tyr Asn Ala Gln Tyr Ser Ser Ala Ser Thr 
                245                 250                 255     


Pro Gln Tyr Pro Thr Ala His Pro Leu Val Gln Ala Gln Gln Trp Thr 
            260                 265                 270         


Trp 
    


<210>  6
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Leu Thr Asn Thr Lys Thr Gly Phe Ser Val Lys Asp Ile Leu 
1               5                   10                  15      


Asp Leu Pro Asp Thr Asn Asp Glu Glu Gly Ser Val Ala Glu Gly Pro 
            20                  25                  30          


Glu Glu Glu Asn Glu Gly Pro Glu Pro Ala Lys Arg Ala Gly Pro Leu 
        35                  40                  45              


Gly Gln Gly Ala Leu Asp Ala Val Gln Ser Leu Pro Leu Lys Asn Pro 
    50                  55                  60                  


Phe Tyr Asp Ser Ser Asp Asn Pro Tyr Thr Arg Trp Leu Ala Ser Thr 
65                  70                  75                  80  


Glu Gly Leu Gln Tyr Ser Leu His Gly Leu Ala Ala Gly Ala Pro Pro 
                85                  90                  95      


Gln Asp Ser Ser Ser Lys Ser Pro Glu Pro Ser Ala Asp Glu Ser Pro 
            100                 105                 110         


Asp Asn Asp Lys Glu Thr Pro Gly Gly Gly Gly Asp Ala Gly Lys Lys 
        115                 120                 125             


Arg Lys Arg Arg Val Leu Phe Ser Lys Ala Gln Thr Tyr Glu Leu Glu 
    130                 135                 140                 


Arg Arg Phe Arg Gln Gln Arg Tyr Leu Ser Ala Pro Glu Arg Glu His 
145                 150                 155                 160 


Leu Ala Ser Leu Ile Arg Leu Thr Pro Thr Gln Val Lys Ile Trp Phe 
                165                 170                 175     


Gln Asn His Arg Tyr Lys Met Lys Arg Ala Arg Ala Glu Lys Gly Met 
            180                 185                 190         


Glu Val Thr Pro Leu Pro Ser Pro Arg Arg Val Ala Val Pro Val Leu 
        195                 200                 205             


Val Arg Asp Gly Lys Pro Cys His Ala Leu Lys Ala Gln Asp Leu Ala 
    210                 215                 220                 


Ala Ala Thr Phe Gln Ala Gly Ile Pro Phe Ser Ala Tyr Ser Ala Gln 
225                 230                 235                 240 


Ser Leu Gln His Met Gln Tyr Asn Ala Gln Tyr Ser Ser Ala Ser Thr 
                245                 250                 255     


Pro Gln Tyr Pro Thr Ala His Pro Leu Val Gln Ala Gln Gln Trp Thr 
            260                 265                 270         


Trp 
    


<210>  7
<211>  349
<212>  PRT
<213>  Mus musculus

<400>  7

Met Gln Gln Asp Gly Leu Ser Ser Val Asn Gln Leu Gly Gly Leu Phe 
1               5                   10                  15      


Val Asn Gly Arg Pro Leu Pro Leu Asp Thr Arg Gln Gln Ile Val Gln 
            20                  25                  30          


Leu Ala Ile Arg Gly Met Arg Pro Cys Asp Ile Ser Arg Ser Leu Lys 
        35                  40                  45              


Val Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Arg Thr 
    50                  55                  60                  


Gly Val Leu Glu Pro Lys Cys Ile Gly Gly Ser Lys Pro Arg Leu Ala 
65                  70                  75                  80  


Thr Pro Ala Val Val Ala Arg Ile Ala Gln Leu Lys Asp Glu Tyr Pro 
                85                  90                  95      


Ala Leu Phe Ala Trp Glu Ile Gln His Gln Leu Cys Thr Glu Gly Leu 
            100                 105                 110         


Cys Thr Gln Asp Lys Ala Pro Ser Val Ser Ser Ile Asn Arg Val Leu 
        115                 120                 125             


Arg Ala Leu Gln Glu Asp Gln Ser Leu His Trp Thr Gln Leu Arg Ser 
    130                 135                 140                 


Pro Ala Val Leu Ala Pro Val Leu Pro Ser Pro His Ser Asn Cys Gly 
145                 150                 155                 160 


Ala Pro Arg Gly Pro His Pro Gly Thr Ser His Arg Asn Arg Thr Ile 
                165                 170                 175     


Phe Ser Pro Gly Gln Ala Glu Ala Leu Glu Lys Glu Phe Gln Arg Gly 
            180                 185                 190         


Gln Tyr Pro Asp Ser Val Ala Arg Gly Lys Leu Ala Ala Ala Thr Ser 
        195                 200                 205             


Leu Pro Glu Asp Thr Val Arg Val Trp Phe Ser Asn Arg Arg Ala Lys 
    210                 215                 220                 


Trp Arg Arg Gln Glu Lys Leu Lys Trp Glu Ala Gln Leu Pro Gly Ala 
225                 230                 235                 240 


Ser Gln Asp Leu Thr Val Pro Lys Asn Ser Pro Gly Ile Ile Ser Ala 
                245                 250                 255     


Gln Gln Ser Pro Gly Ser Val Pro Ser Ala Ala Leu Pro Val Leu Glu 
            260                 265                 270         


Pro Leu Ser Pro Ser Phe Cys Gln Leu Cys Cys Gly Thr Ala Pro Gly 
        275                 280                 285             


Arg Cys Ser Ser Asp Thr Ser Ser Gln Ala Tyr Leu Gln Pro Tyr Trp 
    290                 295                 300                 


Asp Cys Gln Ser Leu Leu Pro Val Ala Ser Ser Ser Tyr Val Glu Phe 
305                 310                 315                 320 


Ala Trp Pro Cys Leu Thr Thr His Pro Val His His Leu Ile Gly Gly 
                325                 330                 335     


Pro Gly Gln Val Pro Ser Thr His Cys Ser Asn Trp Pro 
            340                 345                 


<210>  8
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  8

Met His Gln Asp Gly Ile Ser Ser Met Asn Gln Leu Gly Gly Leu Phe 
1               5                   10                  15      


Val Asn Gly Arg Pro Leu Pro Leu Asp Thr Arg Gln Gln Ile Val Arg 
            20                  25                  30          


Leu Ala Val Ser Gly Met Arg Pro Cys Asp Ile Ser Arg Ile Leu Lys 
        35                  40                  45              


Val Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Arg Thr 
    50                  55                  60                  


Gly Val Leu Glu Pro Lys Gly Ile Gly Gly Ser Lys Pro Arg Leu Ala 
65                  70                  75                  80  


Thr Pro Pro Val Val Ala Arg Ile Ala Gln Leu Lys Gly Glu Cys Pro 
                85                  90                  95      


Ala Leu Phe Ala Trp Glu Ile Gln Arg Gln Leu Cys Ala Glu Gly Leu 
            100                 105                 110         


Cys Thr Gln Asp Lys Thr Pro Ser Val Ser Ser Ile Asn Arg Val Leu 
        115                 120                 125             


Arg Ala Leu Gln Glu Asp Gln Gly Leu Pro Cys Thr Arg Leu Arg Ser 
    130                 135                 140                 


Pro Ala Val Leu Ala Pro Ala Val Leu Thr Pro His Ser Gly Ser Glu 
145                 150                 155                 160 


Thr Pro Arg Gly Thr His Pro Gly Thr Gly His Arg Asn Arg Thr Ile 
                165                 170                 175     


Phe Ser Pro Ser Gln Ala Glu Ala Leu Glu Lys Glu Phe Gln Arg Gly 
            180                 185                 190         


Gln Tyr Pro Asp Ser Val Ala Arg Gly Lys Leu Ala Thr Ala Thr Ser 
        195                 200                 205             


Leu Pro Glu Asp Thr Val Arg Val Trp Phe Ser Asn Arg Arg Ala Lys 
    210                 215                 220                 


Trp Arg Arg Gln Glu Lys Leu Lys Trp Glu Met Gln Leu Pro Gly Ala 
225                 230                 235                 240 


Ser Gln Gly Leu Thr Val Pro Arg Val Ala Pro Gly Ile Ile Ser Ala 
                245                 250                 255     


Gln Gln Ser Pro Gly Ser Val Pro Thr Ala Ala Leu Pro Ala Leu Glu 
            260                 265                 270         


Pro Leu Gly Pro Ser Cys Tyr Gln Leu Cys Trp Ala Thr Ala Pro Glu 
        275                 280                 285             


Arg Cys Leu Ser Asp Thr Pro Pro Lys Ala Cys Leu Lys Pro Cys Trp 
    290                 295                 300                 


Asp Cys Gly Ser Phe Leu Leu Pro Val Ile Ala Pro Ser Cys Val Asp 
305                 310                 315                 320 


Val Ala Trp Pro Cys Leu Asp Ala Ser Leu Ala His His Leu Ile Gly 
                325                 330                 335     


Gly Ala Gly Lys Ala Thr Pro Thr His Phe Ser His Trp Pro 
            340                 345                 350 


<210>  9
<211>  422
<212>  PRT
<213>  Mus musculus

<400>  9

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  10
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  11
<211>  359
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Ala Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Ala Ala Gln Ala Gly Gly Ala Pro Gly Pro Pro Ser 
                85                  90                  95      


Gly Gly Pro Gly Thr Val Gly Gly Ala Ser Gly Lys Ala Val Leu Glu 
            100                 105                 110         


Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro Glu Ala 
        115                 120                 125             


Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly Ser Gly 
    130                 135                 140                 


His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Tyr Glu Ala Phe Arg Gly Gln Ser Phe Ala Gly Gly Gly Gly Ala Asp 
                165                 170                 175     


Asp Met Gly Ala Gly His His His Gly Ala His His Thr Ala His His 
            180                 185                 190         


His His Ser Ala His His His His His His His His His His Gly Gly 
        195                 200                 205             


Ser Gly His His Gly Gly Gly Ala Gly His Gly Gly Gly Gly Ala Gly 
    210                 215                 220                 


His His Val Arg Leu Glu Glu Arg Phe Ser Asp Asp Gln Leu Val Ser 
225                 230                 235                 240 


Met Ser Val Arg Glu Leu Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu 
                245                 250                 255     


Glu Val Ile Arg Leu Lys Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly 
            260                 265                 270         


Tyr Ala Gln Ser Cys Arg Phe Lys Arg Val Gln Gln Arg His Ile Leu 
        275                 280                 285             


Glu Ser Glu Lys Cys Gln Leu Gln Ser Gln Val Glu Gln Leu Lys Leu 
    290                 295                 300                 


Glu Val Gly Arg Leu Ala Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr 
305                 310                 315                 320 


Glu Lys Leu Ala Gly Arg Gly Gly Pro Gly Gly Ala Gly Gly Ala Gly 
                325                 330                 335     


Phe Pro Arg Glu Pro Ser Pro Ala Gln Ala Gly Pro Gly Ala Ala Lys 
            340                 345                 350         


Gly Ala Pro Asp Phe Phe Leu 
        355                 


<210>  12
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Gly Gly Gly Ser Ser Gln Ala Gly Gly Ala Pro Gly Pro 
                85                  90                  95      


Pro Ser Gly Gly Pro Gly Ala Val Gly Gly Thr Ser Gly Lys Pro Ala 
            100                 105                 110         


Leu Glu Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro 
        115                 120                 125             


Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly 
    130                 135                 140                 


Ser Gly His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Tyr Glu Ala Phe Arg Gly Pro Gly Phe Ala Gly Gly Gly Gly 
                165                 170                 175     


Ala Asp Asp Met Gly Ala Gly His His His Gly Ala His His Ala Ala 
            180                 185                 190         


His His His His Ala Ala His His His His His His His His His His 
        195                 200                 205             


Gly Gly Ala Gly His Gly Gly Gly Ala Gly His His Val Arg Leu Glu 
    210                 215                 220                 


Glu Arg Phe Ser Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu 
225                 230                 235                 240 


Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu Glu Val Ile Arg Leu Lys 
                245                 250                 255     


Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg 
            260                 265                 270         


Phe Lys Arg Val Gln Gln Arg His Ile Leu Glu Ser Glu Lys Cys Gln 
        275                 280                 285             


Leu Gln Ser Gln Val Glu Gln Leu Lys Leu Glu Val Gly Arg Leu Ala 
    290                 295                 300                 


Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr Glu Lys Leu Ala Gly Arg 
305                 310                 315                 320 


Gly Gly Pro Gly Ser Ala Gly Gly Ala Gly Phe Pro Arg Glu Pro Ser 
                325                 330                 335     


Pro Pro Gln Ala Gly Pro Gly Gly Ala Lys Gly Thr Ala Asp Phe Phe 
            340                 345                 350         


Leu 
    


<210>  13
<211>  214
<212>  PRT
<213>  Mus musculus

<400>  13

Met Ala Pro His Pro Leu Asp Ala Leu Thr Ile Gln Val Ser Pro Glu 
1               5                   10                  15      


Thr Gln Gln Pro Phe Pro Gly Ala Ser Asp His Glu Val Leu Ser Ser 
            20                  25                  30          


Asn Ser Thr Pro Pro Ser Pro Thr Leu Ile Pro Arg Asp Cys Ser Glu 
        35                  40                  45              


Ala Glu Val Gly Asp Cys Arg Gly Thr Ser Arg Lys Leu Arg Ala Arg 
    50                  55                  60                  


Arg Gly Gly Arg Asn Arg Pro Lys Ser Glu Leu Ala Leu Ser Lys Gln 
65                  70                  75                  80  


Arg Arg Ser Arg Arg Lys Lys Ala Asn Asp Arg Glu Arg Asn Arg Met 
                85                  90                  95      


His Asn Leu Asn Ser Ala Leu Asp Ala Leu Arg Gly Val Leu Pro Thr 
            100                 105                 110         


Phe Pro Asp Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala 
        115                 120                 125             


His Asn Tyr Ile Trp Ala Leu Thr Gln Thr Leu Arg Ile Ala Asp His 
    130                 135                 140                 


Ser Phe Tyr Gly Pro Glu Pro Pro Val Pro Cys Gly Glu Leu Gly Ser 
145                 150                 155                 160 


Pro Gly Gly Gly Ser Asn Gly Asp Trp Gly Ser Ile Tyr Ser Pro Val 
                165                 170                 175     


Ser Gln Ala Gly Asn Leu Ser Pro Thr Ala Ser Leu Glu Glu Phe Pro 
            180                 185                 190         


Gly Leu Gln Val Pro Ser Ser Pro Ser Tyr Leu Leu Pro Gly Ala Leu 
        195                 200                 205             


Val Phe Ser Asp Phe Leu 
    210                 


<210>  14
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Pro Gln Pro Ser Gly Ala Pro Thr Val Gln Val Thr Arg Glu 
1               5                   10                  15      


Thr Glu Arg Ser Phe Pro Arg Ala Ser Glu Asp Glu Val Thr Cys Pro 
            20                  25                  30          


Thr Ser Ala Pro Pro Ser Pro Thr Arg Thr Arg Gly Asn Cys Ala Glu 
        35                  40                  45              


Ala Glu Glu Gly Gly Cys Arg Gly Ala Pro Arg Lys Leu Arg Ala Arg 
    50                  55                  60                  


Arg Gly Gly Arg Ser Arg Pro Lys Ser Glu Leu Ala Leu Ser Lys Gln 
65                  70                  75                  80  


Arg Arg Ser Arg Arg Lys Lys Ala Asn Asp Arg Glu Arg Asn Arg Met 
                85                  90                  95      


His Asn Leu Asn Ser Ala Leu Asp Ala Leu Arg Gly Val Leu Pro Thr 
            100                 105                 110         


Phe Pro Asp Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala 
        115                 120                 125             


His Asn Tyr Ile Trp Ala Leu Thr Gln Thr Leu Arg Ile Ala Asp His 
    130                 135                 140                 


Ser Leu Tyr Ala Leu Glu Pro Pro Ala Pro His Cys Gly Glu Leu Gly 
145                 150                 155                 160 


Ser Pro Gly Gly Ser Pro Gly Asp Trp Gly Ser Leu Tyr Ser Pro Val 
                165                 170                 175     


Ser Gln Ala Gly Ser Leu Ser Pro Ala Ala Ser Leu Glu Glu Arg Pro 
            180                 185                 190         


Gly Leu Leu Gly Ala Thr Phe Ser Ala Cys Leu Ser Pro Gly Ser Leu 
        195                 200                 205             


Ala Phe Ser Asp Phe Leu 
    210                 


<210>  15
<211>  357
<212>  PRT
<213>  Mus musculus

<400>  15

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Glu Leu Glu Ala Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Glu Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Pro Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Pro Gln Ser His Gly Ser Ile Phe Ser Ser 
305                 310                 315                 320 


Gly Ala Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser 
                325                 330                 335     


Phe Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn 
            340                 345                 350         


Ala Ile Phe His Asp 
        355         


<210>  16
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Thr Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                325                 330                 335     


Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
            340                 345                 350         


Ile Phe His Asp 
        355     


<210>  17
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin receptor antagonist S661


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  wherein the two Cys at positions 33 and 40 are joined by a 
       disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  wherein the two Cys at positions 33 and 40 are joined by a 
       disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  wherein Xaa is Tyr with a C-terminal carboxylic acid group 
       replaced by an amide group

<400>  17

Gly Ser Leu Asp Glu Ser Phe Tyr Asp Trp Phe Glu Arg Gln Leu Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Ser Leu Glu Glu Glu Trp Ala Gln Ile Gln 
            20                  25                  30          


Cys Glu Val Trp Gly Arg Gly Cys Pro Ser Xaa 
        35                  40              


<210>  18
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin receptor antagonist S961


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  wherein the two Cys at positions 33 and 40 are joined by a 
       disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  wherein the two Cys at positions 33 and 40 are joined by a 
       disulfide bond

<400>  18

Gly Ser Leu Asp Glu Ser Phe Tyr Asp Trp Phe Glu Arg Gln Leu Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Ser Leu Glu Glu Glu Trp Ala Gln Ile Gln 
            20                  25                  30          


Cys Glu Val Trp Gly Arg Gly Cys Pro Ser Tyr 
        35                  40              


