                               SEQUENCE LISTING

<110> AMGEN INC.
 
<120> BISPECIFIC-FC MOLECULES

<130> A-1883-WO-PCT

<140> --to be assigned--
<141> 2014-03-14

<150> 61/791,424
<151> 2013-03-15

<160> 92    

<170> PatentIn version 3.5

<210> 1
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence immediately preceding HC CDR1"


<220>
<221> MOD_RES
<222> (2)..(9)
<223> Any amino acid

<400> 1
Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence preceding HC CDR2"

<400> 2
Leu Glu Trp Ile Gly 
1               5   


<210> 3
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence following HC CDR3"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 3
Trp Gly Xaa Gly 
1               


<210> 4
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence following LC CDR3"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 4
Phe Gly Xaa Gly 
1               


<210> 5
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of anti-HER2 VH region"

<400> 5
Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Lys Ile Lys Asp 
            20                  25                  30          


Tyr Phe Val Asn Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr Gly Pro Asn 
    50                  55                  60                  


Phe Gln Asp Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Gly 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val 
        115                 


<210> 6
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of anti-HER2 VL region"

<400> 6
Glu Leu Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 7
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of anti-CD3 VH region"

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 8
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of anti-CD3 VL region"

<400> 8
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 9
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a single chain anti-HER2/CD3 
      (P136629.3) P136629.3 aHer2(D3)scFv-aCD3(F12Q)scFv"

<400> 9
Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Lys Ile Lys Asp 
            20                  25                  30          


Tyr Phe Val Asn Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr Gly Pro Asn 
    50                  55                  60                  


Phe Gln Asp Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Gly 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Gln Gln Gly Asn Thr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Ser Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu Ala Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser 
            500                 505                 510         


His His His His His His 
        515             


<210> 10
<211> 742
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an anti-HER2/CD3 Bi-Fc (P136632.3)
      D356K, D399K, L234A, L235A P136632.3 (aHer2(D3)scFv-aCD3
      (F12Q)scFv-FcAAKK)"

<400> 10
Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Lys Ile Lys Asp 
            20                  25                  30          


Tyr Phe Val Asn Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr Gly Pro Asn 
    50                  55                  60                  


Phe Gln Asp Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Gly 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Gln Gln Gly Asn Thr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Ser Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu Ala Ala Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
            500                 505                 510         


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
        515                 520                 525             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    530                 535                 540                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
545                 550                 555                 560 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                565                 570                 575     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            580                 585                 590         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        595                 600                 605             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    610                 615                 620                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
625                 630                 635                 640 


Arg Lys Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                645                 650                 655     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            660                 665                 670         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly 
        675                 680                 685             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    690                 695                 700                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
705                 710                 715                 720 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala 
                725                 730                 735     


His His His His His His 
            740         


<210> 11
<211> 2226
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:10 aHer2(D3)
      scFv-aCD3(F12Q)scFv-FcAAKK)"

<400> 11
gaggtgcagc tgctcgagca gtctggagct gagcttgtga ggccaggggc cttagtcaag       60

ttgtcctgca aagcttctgg cttcaaaatt aaagactact ttgtgaactg ggtgaagcag      120

aggcctgaac agggcctgga gtggattgga tggattgatc ctgagaatga taatagttta      180

tatggcccga acttccagga caaggccagt atcacagcag acacatcctc caacacaggc      240

tacctgcagc tcagcggcct gacatctgag gacactgccg tctattactg tgctctttat      300

tacggaagta ggggggatgc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga gctcgtgatg      420

acccagactc catcctccct gtctgcctct ctgggagaca gagtcaccat cagttgcagg      480

gcaagtcagg acattagcaa ttatttaaac tggtatcagc agaaaccaga tggaactgtt      540

aaactcctga tctactacac atcaagatta cactcaggag tcccatcaag gttcagtggc      600

agtgggtctg gaacagatta ttctctcacc attagcaacc tggagcaaga agatattgcc      660

acttactttt gccaacaggg taatacgctt ccgctcacgt tcggtgctgg gaccaagctt      720

gagatcaaat ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaatagc      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaagg caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta cgtttcctgg     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt cctagcggcc     1500

gcagagccca aatcttctga caaaactcac acatgccccc cgtgcccagc acctgaagca     1560

gctgggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1620

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1680

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgagaggag     1740

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1800

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1860

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1920

cggaaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1980

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     2040

cctcccgtgc tgaagtccga cggctccttc ttcctctata gcaagctcac cgtggacaag     2100

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     2160

cactacacgc agaagagcct ctccctgtct ccgggtaaag ctgcagcgca tcaccaccac     2220

catcac                                                                2226


<210> 12
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence encoding a human IgG1 Fc polypeptide
      containing alterations K392D and K409D, plus L234A and
      L235A"

<400> 12
His Met Ser Ser Val Ser Ala Gln Ala Ala Ala Glu Pro Lys Ser Ser 
1               5                   10                  15      


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            20                  25                  30          


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro 
            180                 185                 190         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val 
        195                 200                 205             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 


Pro Gly Lys 
            


<210> 13
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:12"

<400> 13
cacatgtctt cggtaagtgc acaggcggcc gcagagccca aatcttctga caaaactcac       60

acatgcccac cgtgcccagc acctgaagca gctgggggac cgtcagtctt cctcttcccc      120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      420

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc      480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat      540

gggcagccgg agaacaacta cgacaccacg cctcccgtgc tggactccga cggctccttc      600

ttcctctata gcgacctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct      720

ccgggtaaa                                                              729


<210> 14
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a single chain anti-FOLR1/CD3
      molecule P136637.3 aFOLR1(5G1)scFv-aCD3(F12Q)scFv"

<400> 14
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ala Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ser Ser Ser Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
    130                 135                 140                 


Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
145                 150                 155                 160 


Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Met Leu Ser Ser Gly Val 
            180                 185                 190         


Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
        195                 200                 205             


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Thr Val Leu Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Ser Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu Ala Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser 
            500                 505                 510         


His His His His His His 
        515             


<210> 15
<211> 742
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an anti-FOLR1/CD3 Bi-Fc P136635.4
      (aFOLR1(5G1)scFv-aCD3(F12Q)scFv-FcAAKK)"

<400> 15
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ala Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ser Ser Ser Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
    130                 135                 140                 


Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
145                 150                 155                 160 


Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Met Leu Ser Ser Gly Val 
            180                 185                 190         


Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
        195                 200                 205             


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Thr Val Leu Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Ser Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu Ala Ala Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
            500                 505                 510         


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
        515                 520                 525             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    530                 535                 540                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
545                 550                 555                 560 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                565                 570                 575     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            580                 585                 590         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        595                 600                 605             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    610                 615                 620                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
625                 630                 635                 640 


Arg Lys Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                645                 650                 655     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            660                 665                 670         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly 
        675                 680                 685             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    690                 695                 700                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
705                 710                 715                 720 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala 
                725                 730                 735     


His His His His His His 
            740         


<210> 16
<211> 2226
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:15 (aFOLR1(5G1)
      scFv-aCD3(F12Q)scFv-FcAAKK)"

<400> 16
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtgctt actactggac ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttagc atatcaatag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgcgaggc      300

agcagcagct ggttcgacta ctggggccag ggaaccctgg tcaccgtctc ctcaggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtc agtctgtgct gactcagcca      420

ccctcggtgt ctgaagcccc caggcagagg gtcaccatct cctgttctgg aagcagctcc      480

aacatcggaa ataatgctgt aaactggtac cagcagctcc caggaaaggc tcccaaactc      540

ctcatctatt atgatgatat gttgtcttca ggggtctcgg accgattttc tggctccaag      600

tctggcacct cagcctccct ggccatcagt gggctccagt ctgaggatga ggctgattat      660

tactgtgcag catgggatga cagcctgaat ggtgtggtat tcggcggagg gaccaagctg      720

accgtcctat ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaatagc      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcata      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaagg caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaaaactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta cgtttcctgg     1080

tgggcttact ggggccaagg gactctggtc accgtctcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaataggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcagaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt cctagcggcc     1500

gcagagccca aatcttctga caaaactcac acatgccccc cgtgcccagc acctgaagca     1560

gctgggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1620

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1680

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgagaggag     1740

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1800

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1860

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1920

cggaaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1980

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     2040

cctcccgtgc tgaagtccga cggctccttc ttcctctata gcaagctcac cgtggacaag     2100

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     2160

cactacacgc agaagagcct ctccctgtct ccgggtaaag ctgcagcgca tcaccaccac     2220

catcac                                                                2226


<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker peptide"

<400> 17
Thr Val Ala Ala Pro 
1               5   


<210> 18
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker peptide"

<400> 18
Ala Ser Thr Lys Gly Pro 
1               5       


<210> 19
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker peptide"

<400> 19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker peptide"

<400> 20
Gly Gly Gly Gly Ser Ala Ala Ala 
1               5               


<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      linker peptide"

<400> 21
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 22
<211> 186
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Mature amino acid sequence of CD3 epsilon chain of 
      Homo sapiens"

<400> 22
Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile 
            100                 105                 110         


Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr 
        115                 120                 125             


Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly 
    130                 135                 140                 


Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro 
145                 150                 155                 160 


Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp 
                165                 170                 175     


Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
            180                 185     


<210> 23
<211> 177
<212> PRT
<213> Macaca fascicularis

<220>
<221> source
<223> /note="Mature amino acid sequence of CD3 epsilon chain of
      Macaca fascicularis"

<400> 23
Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr Gln Thr Pro Tyr Gln 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Ser Gln His Leu 
            20                  25                  30          


Gly Ser Glu Ala Gln Trp Gln His Asn Gly Lys Asn Lys Gly Asp Ser 
        35                  40                  45              


Gly Asp Gln Leu Phe Leu Pro Glu Phe Ser Glu Met Glu Gln Ser Gly 
    50                  55                  60                  


Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Asn Pro Glu Asp Ala Ser His 
65                  70                  75                  80  


His Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
                85                  90                  95      


Val Met Ala Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Leu 
            100                 105                 110         


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys 
        115                 120                 125             


Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly 
    130                 135                 140                 


Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro 
145                 150                 155                 160 


Ile Arg Lys Gly Gln Gln Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg 
                165                 170                 175     


Ile 
    


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide which is a portion of an epitope of CD3 epsilon"

<400> 24
Gln Asp Gly Asn Glu 
1               5   


<210> 25
<211> 232
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="amino acid sequence of human IgG1 Fc region"

<400> 25
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 26
<211> 228
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="amino acid sequence of human IgG2 Fc region"

<400> 26
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210> 27
<211> 279
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="amino acid sequence of human IgG3 Fc region"

<400> 27
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
65                  70                  75                  80  


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                85                  90                  95      


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp 
            100                 105                 110         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        115                 120                 125             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    130                 135                 140                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
145                 150                 155                 160 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                165                 170                 175     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            180                 185                 190         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        195                 200                 205             


Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn 
    210                 215                 220                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
225                 230                 235                 240 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser 
                245                 250                 255     


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
            260                 265                 270         


Leu Ser Leu Ser Pro Gly Lys 
        275                 


<210> 28
<211> 229
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="amino acid sequence of human IgG4 Fc region"

<400> 28
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 29
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an anti-CD3-epsilon VH region
      (12C)"

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 30
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:29"

<400> 30
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210> 31
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an anti-CD3-epsilon VL region 
      (12C)"

<400> 31
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 32
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:31"

<400> 32
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210> 33
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an anti-CD33/CD3 bispecific single 
      chain molecule"

<400> 33
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu His His His His His His 
            500                 505                 510     


<210> 34
<211> 728
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of monomeric anti-CD33/CD3 Bi-Fc"

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Pro Glu Leu Leu Gly Gly 
            500                 505                 510         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        515                 520                 525             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    530                 535                 540                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
545                 550                 555                 560 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
                565                 570                 575     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            580                 585                 590         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        595                 600                 605             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Thr 
    610                 615                 620                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
625                 630                 635                 640 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                645                 650                 655     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val 
            660                 665                 670         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp 
        675                 680                 685             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    690                 695                 700                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
705                 710                 715                 720 


Gly Lys His His His His His His 
                725             


<210> 35
<211> 1643
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:34"

<400> 35
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagagtc tgtcaaagtc       60

agctgcaagg cctccggcta caccttcacc aactacggca tgaactgggt gaaacaggct      120

ccaggacagg gactcgagtg gatgggctgg atcaacacct acaccggcga gcctacctac      180

gccgacaagt tccagggcag agtgaccatg accaccgaca catctaccag cacagcttac      240

atggaaatcc ggaacctggg cggcgacgac accgccgtgt actactgcgc ccggtggtct      300

tggtccgacg gctactacgt gtacttcgac tactggggcc agggcacctc cgtgacagtg      360

tccagcggag ggggaggaag tggcggaggg ggctctggag gtggcggctc cgacatcgtg      420

atgacccagt cccccgactc cctgaccgtg tccctgggcg agcggaccac catcaactgc      480

aagtcctccc agtccgtgct ggactcctcc accaacaaga actccctggc ctggtatcag      540

cagaagcctg gccagcctcc taagctgctg ctctcttggg cttccaccag agagagcggg      600

attcccgata ggttctccgg ctctggctcc ggcaccgact tcaccctgac catcgactcc      660

cctcagcctg aggactccgc cacctactac tgccagcagt ccgcccactt ccctatcacc      720

ttcggccagg gaacccggct ggaaatcaag tctggcggcg gtggctctga agtgcagctc      780

gtggagagtg gcggaggact ggtgcagcca ggcggctccc tgaagctgtc ttgcgccgcc      840

agcggcttca ccttcaataa gtacgctatg aattgggtcc ggcaggcacc tggaaaaggg      900

ctcgaatggg tcgcaaggat taggtctaag tacaacaact acgccaccta ttacgccgac      960

tctgtgaagg accggttcac catctcccgg gacgactcta agaacaccgc ttacctgcag     1020

atgaacaacc tgaaaaccga ggataccgct gtgtactatt gtgtgcggca cggcaacttc     1080

ggcaactcct acatctccta ctgggcctat tggggacagg gcacactggt caccgtgtcc     1140

tctggcggtg gaggatctgg tggcggcgga tctggcggcg gaggttccca gaccgtggtc     1200

acccaggaac cttctctgac cgtcagtccc ggcggaaccg tgaccctgac ctgtggctcc     1260

tctaccggcg ctgtgacctc cggcaactac cctaactggg tgcagcagaa acccggccag     1320

gctcccagag gactcatcgg cggcaccaag tttctggccc ctggcacccc tgccagattc     1380

tctggctccc tgctgggcgg caaggctgct ctgaccctga gcggagtcca gccagaggac     1440

gaggccgagt actactgtgt gctgtggtac tccaacagat gggtgttcgg cggtggcacc     1500

aagctgaccg tgctggcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1560

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1620

gtgagccacg aagaccctga ggt                                             1643


<210> 36
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half
      life"

<400> 36
Gly Gly Cys Val Phe Asn Met Phe Asn Cys Gly Gly 
1               5                   10          


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 37
Gly Gly Cys His Leu Pro Phe Ala Val Cys Gly Gly 
1               5                   10          


<210> 38
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 38
Gly Gly Cys Gly His Glu Tyr Met Trp Cys Gly Gly 
1               5                   10          


<210> 39
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 39
Gly Gly Cys Trp Pro Leu Gln Asp Tyr Cys Gly Gly 
1               5                   10          


<210> 40
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 40
Gly Gly Cys Met Gln Met Asn Lys Trp Cys Gly Gly 
1               5                   10          


<210> 41
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 41
Gly Gly Cys Asp Gly Arg Thr Lys Tyr Cys Gly Gly 
1               5                   10          


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 42
Gly Gly Cys Ala Leu Tyr Pro Thr Asn Cys Gly Gly 
1               5                   10          


<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 43
Gly Gly Cys Gly Lys His Trp His Gln Cys Gly Gly 
1               5                   10          


<210> 44
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 44
Gly Gly Cys His Ser Phe Lys His Phe Cys Gly Gly 
1               5                   10          


<210> 45
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 45
Gly Gly Cys Gln Gly Met Trp Thr Trp Cys Gly Gly 
1               5                   10          


<210> 46
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 46
Gly Gly Cys Ala Gln Gln Trp His His Glu Tyr Cys Gly Gly 
1               5                   10                  


<210> 47
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an insertion that prolongs half 
      life"

<400> 47
Gly Gly Cys Glu Arg Phe His His Ala Cys Gly Gly 
1               5                   10          


<210> 48
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR1 which is part
      of SEQ ID NO:7"

<400> 48
Ser Tyr Ala Met Asn 
1               5   


<210> 49
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR2 which is part
      of SEQ ID NO:7"

<400> 49
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 50
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR3 which is part
      of SEQ ID NO:7"

<400> 50
His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr 
1               5                   10                  


<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR1 which is part
      of SEQ ID NO:8"

<400> 51
Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR2 which is part
      of SEQ ID NO:8"

<400> 52
Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210> 53
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR3 which is part
      of SEQ ID NO:8"

<400> 53
Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR1 which is part
      of SEQ ID NO:29"

<400> 54
Lys Tyr Ala Met Asn 
1               5   


<210> 55
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR2 which is part
      of SEQ ID NO:29"

<400> 55
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 56
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR3 which is part
      of SEQ ID NO:29"

<400> 56
His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210> 57
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR1 which is part
      of SEQ ID NO:31"

<400> 57
Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR2 which is part
      of SEQ ID NO:31"

<400> 58
Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210> 59
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR3 which is part
      of SEQ ID NO:31"

<400> 59
Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210> 60
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH CDR1 of SEQ ID NO:5"

<400> 60
Asp Tyr Phe Val Asn 
1               5   


<210> 61
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH CDR2 of SEQ ID NO:5"

<400> 61
Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr Gly Pro Asn Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 62
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH CDR3 of SEQ ID NO:5"

<400> 62
Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp Tyr 
1               5                   10      


<210> 63
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL CDR1 of SEQ ID NO:6"

<400> 63
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210> 64
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL CDR2 of SEQ ID NO:6"

<400> 64
Tyr Thr Ser Arg Leu His Ser 
1               5           


<210> 65
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL CDR3 of SEQ ID NO:6"

<400> 65
Gln Gln Gly Asn Thr Leu Pro Leu Thr 
1               5                   


<210> 66
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR1 of SEQ ID NO:15"

<400> 66
Ser Gly Ala Tyr Tyr 
1               5   


<210> 67
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR2 of SEQ ID NO:15"

<400> 67
Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR2 of SEQ ID NO:15"

<400> 68
Gly Ser Ser Ser Trp Phe Asp Tyr 
1               5               


<210> 69
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR1 of SEQ ID NO:15"

<400> 69
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210> 70
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR2 of SEQ ID NO:15"

<400> 70
Tyr Asp Asp Met Leu Ser Ser 
1               5           


<210> 71
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR3 of SEQ ID NO:15"

<400> 71
Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210> 72
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR1 of SEQ ID NO:34"

<400> 72
Asn Tyr Gly Met Asn 
1               5   


<210> 73
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR2 of SEQ ID NO:34"

<400> 73
Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 74
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VH region CDR3 of SEQ ID NO:34"

<400> 74
Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr 
1               5                   10              


<210> 75
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR1 of SEQ ID NO:34"

<400> 75
Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR2 of SEQ ID NO:34"

<400> 76
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a VL region CDR3 of SEQ ID NO:34"

<400> 77
Gln Gln Ser Ala His Phe Pro Ile Thr 
1               5                   


<210> 78
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an anti-Mec/CD3-epsilon single
      chain bispecific (P137424.7)"

<400> 78
Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly Thr 
1               5                   10                  15      


Val Thr Ile Asn Cys Gln Ser Ser Pro Ser Leu Ile Tyr Asp Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser His Asp Thr Asn Pro Gly 
                85                  90                  95      


Ser Ser Thr Tyr Gly Ala Pro Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 
    130                 135                 140                 


Ser Leu Thr Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Thr Ser 
145                 150                 155                 160 


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Pro Glu Trp Ile 
                165                 170                 175     


Ala Gly Ile Tyr Asn Gly Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Val 
            180                 185                 190         


Asn Gly Arg Phe Ser Ile Ser Arg Ser Thr Ser Leu Asn Thr Val Thr 
        195                 200                 205             


Leu Gln Met Thr Arg Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Trp Ile Arg Ile His Tyr Ser Phe Asp Leu Trp Gly Pro Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 


Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     


Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         


Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
385                 390                 395                 400 


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
                405                 410                 415     


Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
        435                 440                 445             


Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
    450                 455                 460                 


Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
465                 470                 475                 480 


Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Thr Val Leu His His His His His His 
            500                 505             


<210> 79
<211> 1527
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Polynucleotide sequence encoding the amino acid sequence
      of the anti-Mec/CD3-epsilon single chain bispecific 
     (P137424.7)"

<400> 79
gtcctcactc agaccccttc tccggtctcc gcggccgtcg gcggaactgt cactatcaat       60

tgccagagtt ccccaagtct gatctatgac agtagattag cctggtatca gcaaaaacca      120

gggcaaccac ctaagctcct gatctataaa gcatccactt tggccagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacacag ttcactctca caatcagcga cgtccagtct      240

gacgatgccg caacttatta ctgtcaaagt catgacacta atcctgggtc tagtacttat      300

ggcgccccat tcggaggagg cactgaagtc gtagtccagg gtggtggtgg ttctggcggc      360

ggcggctcca gtggtggtgg ttctgaggtg cagctgatgg agtctggggg aggcttggta      420

aagcccgagg ggtccctgac cctcacctgc aaggtctctg gattctcctt ttcaacgagt      480

gccattagct gggtccgcca ggctccaggg aagagaccag agtggatcgc cgggatttat      540

aacggaggtg gtagcacata ctacgcatcc tgggtgaacg gccggttcag catctccaga      600

tccacgtcct tgaacacggt gacgctgcaa atgaccagac tgacggccgc tgacacggcc      660

acatatttct gtgcgagatg gattcggatc cattattcct tcgacctgtg gggacctggc      720

acgttggtca ccgtctcctc atccggaggt ggtggctccg aggtgcagct ggtcgagtct      780

ggaggaggat tggtgcagcc tggagggtca ttgaaactct catgtgcagc ctctggattc      840

accttcaata agtacgccat gaactgggtc cgccaggctc caggaaaggg tttggaatgg      900

gttgctcgca taagaagtaa atataataat tatgcaacat attatgccga ttcagtgaaa      960

gacaggttca ccatctccag agatgattca aaaaacactg cctatctaca aatgaacaac     1020

ttgaaaactg aggacactgc cgtgtactac tgtgtgagac atgggaactt cggtaatagc     1080

tacatatcct actgggctta ctggggccaa gggactctgg tcaccgtctc ctcaggtggt     1140

ggtggttctg gcggcggcgg ctccggtggt ggtggttctc agactgttgt gactcaggaa     1200

ccttcactca ccgtatcacc tggtggaaca gtcacactca cttgtggctc ctcgactggg     1260

gctgttacat ctggcaacta cccaaactgg gtccaacaaa aaccaggtca ggcaccccgt     1320

ggtctaatag gtgggactaa gttcctcgcc cccggtactc ctgccagatt ctcaggctcc     1380

ctgcttggag gcaaggctgc cctcaccctc tcaggggtac agccagagga tgaggcagaa     1440

tattactgtg ttctatggta cagcaaccgc tgggtgttcg gtggaggaac caaactgact     1500

gtcctacatc atcaccatca tcattag                                         1527


<210> 80
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of the first polypeptide chain of
      a heterodimeric anti-CD33/CD3-epsilon Bi-Fc aCD33(AMG330)
      -scFv-aCD3(I2C)-scFv-Fc(L234A, L235A, E356K, D399K (PL-31769)"

<400> 80
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Lys Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys His His His His His His 
            740             


<210> 81
<211> 2232
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:80"

<400> 81
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagagtc tgtcaaagtc       60

agctgcaagg cctccggcta caccttcacc aactacggca tgaactgggt gaaacaggct      120

ccaggacagg gactcgagtg gatgggctgg atcaacacct acaccggcga gcctacctac      180

gccgacaagt tccagggcag agtgaccatg accaccgaca catctaccag cacagcttac      240

atggaaatcc ggaacctggg cggcgacgac accgccgtgt actactgcgc ccggtggtct      300

tggtccgacg gctactacgt gtacttcgac tactggggcc agggcacctc cgtgacagtg      360

tccagcggag ggggaggaag tggcggaggg ggctctggag gtggcggctc cgacatcgtg      420

atgacccagt cccccgactc cctgaccgtg tccctgggcg agcggaccac catcaactgc      480

aagtcctccc agtccgtgct ggactcctcc accaacaaga actccctggc ctggtatcag      540

cagaagcctg gccagcctcc taagctgctg ctctcttggg cttccaccag agagagcggg      600

attcccgata ggttctccgg ctctggctcc ggcaccgact tcaccctgac catcgactcc      660

cctcagcctg aggactccgc cacctactac tgccagcagt ccgcccactt ccctatcacc      720

ttcggccagg gaacccggct ggaaatcaag tctggcggcg gtggctctga agtgcagctc      780

gtggagagtg gcggaggact ggtgcagcca ggcggctccc tgaagctgtc ttgcgccgcc      840

agcggcttca ccttcaataa gtacgctatg aattgggtcc ggcaggcacc tggaaaaggg      900

ctcgaatggg tcgcaaggat taggtctaag tacaacaact acgccaccta ttacgccgac      960

tctgtgaagg accggttcac catctcccgg gacgactcta agaacaccgc ttacctgcag     1020

atgaacaacc tgaaaaccga ggataccgct gtgtactatt gtgtgcggca cggcaacttc     1080

ggcaactcct acatctccta ctgggcctat tggggacagg gcacactggt caccgtgtcc     1140

tctggcggtg gaggatctgg tggcggcgga tctggcggcg gaggttccca gaccgtggtc     1200

acccaggaac cttctctgac cgtcagtccc ggcggaaccg tgaccctgac ctgtggctcc     1260

tctaccggcg ctgtgacctc cggcaactac cctaactggg tgcagcagaa acccggccag     1320

gctcccagag gactcatcgg cggcaccaag tttctggccc ctggcacccc tgccagattc     1380

tctggctccc tgctgggcgg caaggctgct ctgaccctga gcggagtcca gccagaggac     1440

gaggccgagt actactgtgt gctgtggtac tccaacagat gggtgttcgg cggtggcacc     1500

aagctgaccg tgctggagcc caaatcttct gacaaaactc acacatgccc cccgtgccca     1560

gcacctgaag cagctggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1620

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1680

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1740

ccgcgagagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1800

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1860

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1920

ctgcccccat cccggaagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1980

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     2040

tacaagacca cgcctcccgt gctgaagtcc gacggctcct tcttcctcta tagcaagctc     2100

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     2160

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa acatcatcat     2220

catcatcatt aa                                                         2232


<210> 82
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of an Fc polypeptide chain dummyFc-AADD"

<400> 82
His Met Ser Ser Val Ser Ala Gln Ala Ala Ala Glu Pro Lys Ser Ser 
1               5                   10                  15      


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            20                  25                  30          


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro 
            180                 185                 190         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val 
        195                 200                 205             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 


Pro Gly Lys 
            


<210> 83
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:82"

<400> 83
cacatgtctt cggtaagtgc acaggcggcc gcagagccca aatcttctga caaaactcac       60

acatgcccac cgtgcccagc acctgaagca gctgggggac cgtcagtctt cctcttcccc      120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      420

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc      480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat      540

gggcagccgg agaacaacta cgacaccacg cctcccgtgc tggactccga cggctccttc      600

ttcctctata gcgacctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct      720

ccgggtaaa                                                              729


<210> 84
<211> 728
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of a monomeric anti-CD33/CD3 Bi-Fc having
      the wild type sequence at residue N297 in the Fc portion
      of the molecule aCD33(AMF330)scFv-aCD3(I2C)scFv-Fc-mono"

<400> 84
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Pro Glu Leu Leu Gly Gly 
            500                 505                 510         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        515                 520                 525             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    530                 535                 540                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
545                 550                 555                 560 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                565                 570                 575     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            580                 585                 590         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        595                 600                 605             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Thr 
    610                 615                 620                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
625                 630                 635                 640 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                645                 650                 655     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val 
            660                 665                 670         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp 
        675                 680                 685             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    690                 695                 700                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
705                 710                 715                 720 


Gly Lys His His His His His His 
                725             


<210> 85
<211> 2187
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:84"

<400> 85
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagagtc tgtcaaagtc       60

agctgcaagg cctccggcta caccttcacc aactacggca tgaactgggt gaaacaggct      120

ccaggacagg gactcgagtg gatgggctgg atcaacacct acaccggcga gcctacctac      180

gccgacaagt tccagggcag agtgaccatg accaccgaca catctaccag cacagcttac      240

atggaaatcc ggaacctggg cggcgacgac accgccgtgt actactgcgc ccggtggtct      300

tggtccgacg gctactacgt gtacttcgac tactggggcc agggcacctc cgtgacagtg      360

tccagcggag ggggaggaag tggcggaggg ggctctggag gtggcggctc cgacatcgtg      420

atgacccagt cccccgactc cctgaccgtg tccctgggcg agcggaccac catcaactgc      480

aagtcctccc agtccgtgct ggactcctcc accaacaaga actccctggc ctggtatcag      540

cagaagcctg gccagcctcc taagctgctg ctctcttggg cttccaccag agagagcggg      600

attcccgata ggttctccgg ctctggctcc ggcaccgact tcaccctgac catcgactcc      660

cctcagcctg aggactccgc cacctactac tgccagcagt ccgcccactt ccctatcacc      720

ttcggccagg gaacccggct ggaaatcaag tctggcggcg gtggctctga agtgcagctc      780

gtggagagtg gcggaggact ggtgcagcca ggcggctccc tgaagctgtc ttgcgccgcc      840

agcggcttca ccttcaataa gtacgctatg aattgggtcc ggcaggcacc tggaaaaggg      900

ctcgaatggg tcgcaaggat taggtctaag tacaacaact acgccaccta ttacgccgac      960

tctgtgaagg accggttcac catctcccgg gacgactcta agaacaccgc ttacctgcag     1020

atgaacaacc tgaaaaccga ggataccgct gtgtactatt gtgtgcggca cggcaacttc     1080

ggcaactcct acatctccta ctgggcctat tggggacagg gcacactggt caccgtgtcc     1140

tctggcggtg gaggatctgg tggcggcgga tctggcggcg gaggttccca gaccgtggtc     1200

acccaggaac cttctctgac cgtcagtccc ggcggaaccg tgaccctgac ctgtggctcc     1260

tctaccggcg ctgtgacctc cggcaactac cctaactggg tgcagcagaa acccggccag     1320

gctcccagag gactcatcgg cggcaccaag tttctggccc ctggcacccc tgccagattc     1380

tctggctccc tgctgggcgg caaggctgct ctgaccctga gcggagtcca gccagaggac     1440

gaggccgagt actactgtgt gctgtggtac tccaacagat gggtgttcgg cggtggcacc     1500

aagctgaccg tgctggcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1560

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1620

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1680

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1740

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1800

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1860

ccacaggtga ctaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1920

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1980

cagccggaga acaactacga caccacgcct cccgtgctgg actccgacgg ctccttcttc     2040

ctctatagcg acctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2100

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2160

ggtaaacatc atcatcatca tcattga                                         2187


<210> 86
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of anti-FOLR1/CD3-epsilon Bi-Fc 
      (PL-30058) ahuFolateR-1(5G1)-scFv-ahuCD3(I2C)scFv-FcAAKK"

<400> 86
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ala Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ser Ser Ser Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
    130                 135                 140                 


Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
145                 150                 155                 160 


Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Met Leu Ser Ser Gly Val 
            180                 185                 190         


Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
        195                 200                 205             


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Thr Val Leu Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            500                 505                 510         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        515                 520                 525             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    530                 535                 540                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
545                 550                 555                 560 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                565                 570                 575     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            580                 585                 590         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        595                 600                 605             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    610                 615                 620                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu 
625                 630                 635                 640 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                645                 650                 655     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            660                 665                 670         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe 
        675                 680                 685             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    690                 695                 700                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
705                 710                 715                 720 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His His His 
                725                 730                 735     


<210> 87
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:86"

<400> 87
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtgctt actactggac ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttagc atatcaatag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgcgaggc      300

agcagcagct ggttcgacta ctggggccag ggaaccctgg tcaccgtctc ctcaggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtc agtctgtgct gactcagcca      420

ccctcggtgt ctgaagcccc caggcagagg gtcaccatct cctgttctgg aagcagctcc      480

aacatcggaa ataatgctgt aaactggtac cagcagctcc caggaaaggc tcccaaactc      540

ctcatctatt atgatgatat gttgtcttca ggggtctcgg accgattttc tggctccaag      600

tctggcacct cagcctccct ggccatcagt gggctccagt ctgaggatga ggctgattat      660

tactgtgcag catgggatga cagcctgaat ggtgtggtat tcggcggagg gaccaagctg      720

accgtcctat ccggaggtgg tggatccgaa gtgcagctcg tggagagtgg cggaggactg      780

gtgcagccag gcggctccct gaagctgtct tgcgccgcca gcggcttcac cttcaataag      840

tacgctatga attgggtccg gcaggcacct ggaaaagggc tcgaatgggt cgcaaggatt      900

aggtctaagt acaacaacta cgccacctat tacgccgact ctgtgaagga ccggttcacc      960

atctcccggg acgactctaa gaacaccgct tacctgcaga tgaacaacct gaaaaccgag     1020

gataccgctg tgtactattg tgtgcggcac ggcaacttcg gcaactccta catctcctac     1080

tgggcctatt ggggacaggg cacactggtc accgtgtcct ctggcggtgg aggatctggt     1140

ggcggcggat ctggcggcgg aggttcccag accgtggtca cccaggaacc ttctctgacc     1200

gtcagtcccg gcggaaccgt gaccctgacc tgtggctcct ctaccggcgc tgtgacctcc     1260

ggcaactacc ctaactgggt gcagcagaaa cccggccagg ctcccagagg actcatcggc     1320

ggcaccaagt ttctggcccc tggcacccct gccagattct ctggctccct gctgggcggc     1380

aaggctgctc tgaccctgag cggagtccag ccagaggacg aggccgagta ctactgtgtg     1440

ctgtggtact ccaacagatg ggtgttcggc ggtggcacca agctgaccgt gctggagccc     1500

aaatcttctg acaaaactca cacatgcccc ccgtgcccag cacctgaagc agctggggga     1560

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1620

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1680

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgagagga gcagtacaac     1740

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1800

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1860

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccggaaggag     1920

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1980

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     2040

ctgaagtccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     2100

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2160

cagaagagcc tctccctgtc tccgggtaaa catcaccacc accatcactg a              2211


<210> 88
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence encoding an Fc polypeptide chain"

<400> 88
His Met Ser Ser Val Ser Ala Gln Ala Ala Ala Glu Pro Lys Ser Ser 
1               5                   10                  15      


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            20                  25                  30          


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro 
            180                 185                 190         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val 
        195                 200                 205             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 


Pro Gly Lys 
            


<210> 89
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:88"

<400> 89
cacatgtctt cggtaagtgc acaggcggcc gcagagccca aatcttctga caaaactcac       60

acatgcccac cgtgcccagc acctgaagca gctgggggac cgtcagtctt cctcttcccc      120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      420

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc      480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat      540

gggcagccgg agaacaacta cgacaccacg cctcccgtgc tggactccga cggctccttc      600

ttcctctata gcgacctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct      720

ccgggtaaa                                                              729


<210> 90
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Amino acid sequence of a single chain anti-FOLR1/CD3-epsilon
      Bispecific PL-30055 aFOLR1(5G1)scFv-aCD3(I2C)scFv"

<400> 90
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ala Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ser Ser Ser Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
    130                 135                 140                 


Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
145                 150                 155                 160 


Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Met Leu Ser Ser Gly Val 
            180                 185                 190         


Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
        195                 200                 205             


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
    210                 215                 220                 


Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Thr Val Leu Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu His His His His His His 
            500                 


<210> 91
<211> 1515
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      nucleic acid sequence encoding SEQ ID NO:90"

<400> 91
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtgctt actactggac ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttagc atatcaatag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgcgaggc      300

agcagcagct ggttcgacta ctggggccag ggaaccctgg tcaccgtctc ctcaggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtc agtctgtgct gactcagcca      420

ccctcggtgt ctgaagcccc caggcagagg gtcaccatct cctgttctgg aagcagctcc      480

aacatcggaa ataatgctgt aaactggtac cagcagctcc caggaaaggc tcccaaactc      540

ctcatctatt atgatgatat gttgtcttca ggggtctcgg accgattttc tggctccaag      600

tctggcacct cagcctccct ggccatcagt gggctccagt ctgaggatga ggctgattat      660

tactgtgcag catgggatga cagcctgaat ggtgtggtat tcggcggagg gaccaagctg      720

accgtcctat ccggaggtgg tggatccgaa gtgcagctcg tggagagtgg cggaggactg      780

gtgcagccag gcggctccct gaagctgtct tgcgccgcca gcggcttcac cttcaataag      840

tacgctatga attgggtccg gcaggcacct ggaaaagggc tcgaatgggt cgcaaggatt      900

aggtctaagt acaacaacta cgccacctat tacgccgact ctgtgaagga ccggttcacc      960

atctcccggg acgactctaa gaacaccgct tacctgcaga tgaacaacct gaaaaccgag     1020

gataccgctg tgtactattg tgtgcggcac ggcaacttcg gcaactccta catctcctac     1080

tgggcctatt ggggacaggg cacactggtc accgtgtcct ctggcggtgg aggatctggt     1140

ggcggcggat ctggcggcgg aggttcccag accgtggtca cccaggaacc ttctctgacc     1200

gtcagtcccg gcggaaccgt gaccctgacc tgtggctcct ctaccggcgc tgtgacctcc     1260

ggcaactacc ctaactgggt gcagcagaaa cccggccagg ctcccagagg actcatcggc     1320

ggcaccaagt ttctggcccc tggcacccct gccagattct ctggctccct gctgggcggc     1380

aaggctgctc tgaccctgag cggagtccag ccagaggacg aggccgagta ctactgtgtg     1440

ctgtggtact ccaacagatg ggtgttcggc ggtggcacca agctgaccgt gctgcatcac     1500

caccaccatc actga                                                      1515


<210> 92
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 92
His His His His His His 
1               5       


