                         SEQUENCE LISTING

<110>  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
 
<120>  Novel Allosteric Inhibitors of Thymidylate Synthase

<130>  UF.1100XC1PCT

<150>  US 61/786,910
<151>  2013-03-15

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  1

His His His His His His Met Pro Val Ala Gly Ser Glu Leu Pro Arg 
1               5                   10                  15      


Arg Pro Leu Pro Pro Ala Ala Gln Glu Arg Asp Ala Glu Pro Arg Pro 
            20                  25                  30          


Pro His Gly Glu Leu Gln Tyr Leu Gly Gln Ile Gln His Ile Leu Arg 
        35                  40                  45              


Cys Gly Val Arg Lys Asp Asp Arg Thr Gly Thr Gly Thr Leu Ser Val 
    50                  55                  60                  


Phe Gly Met Gln Ala Arg Tyr Ser Leu Arg Asp Glu Phe Pro Leu Leu 
65                  70                  75                  80  


Thr Thr Lys Arg Val Phe Trp Lys Gly Val Leu Glu Glu Leu Leu Trp 
                85                  90                  95      


Phe Ile Lys Gly Ser Thr Asn Ala Lys Glu Leu Ser Ser Lys Gly Val 
            100                 105                 110         


Lys Ile Trp Asp Ala Asn Gly Ser Arg Asp Phe Leu Asp Ser Leu Gly 
        115                 120                 125             


Phe Ser Thr Arg Glu Glu Gly Asp Leu Gly Pro Val Tyr Gly Phe Gln 
    130                 135                 140                 


Trp Arg His Phe Gly Ala Glu Tyr Arg Asp Met Glu Ser Asp Tyr Ser 
145                 150                 155                 160 


Gly Gln Gly Val Asp Gln Leu Gln Arg Val Ile Asp Thr Ile Lys Thr 
                165                 170                 175     


Asn Pro Asp Asp Arg Arg Ile Ile Met Cys Ala Trp Asn Pro Arg Asp 
            180                 185                 190         


Leu Pro Leu Met Ala Leu Pro Pro Cys His Ala Leu Cys Gln Phe Tyr 
        195                 200                 205             


Val Val Asn Ser Glu Leu Ser Cys Gln Leu Tyr Gln Arg Ser Gly Asp 
    210                 215                 220                 


Met Gly Leu Gly Val Pro Phe Asn Ile Ala Ser Tyr Ala Leu Leu Thr 
225                 230                 235                 240 


Tyr Met Ile Ala His Ile Thr Gly Leu Lys Pro Gly Asp Phe Ile His 
                245                 250                 255     


Thr Leu Gly Asp Ala His Ile Tyr Leu Asn His Ile Glu Pro Leu Lys 
            260                 265                 270         


Ile Gln Leu Gln Arg Glu Pro Arg Pro Phe Pro Lys Leu Arg Ile Leu 
        275                 280                 285             


Arg Lys Val Glu Lys Ile Asp Asp Phe Lys Ala Glu Asp Phe Gln Ile 
    290                 295                 300                 


Glu Gly Tyr Asn Pro His Pro Thr Ile Lys Met Glu Met Ala Val 
305                 310                 315                 


