                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
	 Chi, Ellen
       Connor, Judith
       Huang, Chichi
       Jordan, Jarrat
       Lin-Schmidt, Xiefang
	 Luo, Jinquan
       Lu, Lu
       Martinez, Christian
       Obmolova, Galina
       Swanson, Ronald
 
<120>  Interferon Alpha and Omega Antibody Antagonists

<130>  JBI5025WOPCT

<140>  To Be Assigned
<141>  2014-03-13

<150>  61788302
<151>  2013-03-15

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  1

Cys Asp Leu Pro Gln Asn His Gly Leu Leu Ser Arg Asn Thr Leu Val 
1               5                   10                  15      


Leu Leu His Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Arg Phe Pro Gln Glu Met Val Lys Gly Ser Gln Leu 
        35                  40                  45              


Gln Lys Ala His Val Met Ser Val Leu His Glu Met Leu Gln Gln Ile 
    50                  55                  60                  


Phe Ser Leu Phe His Thr Glu Arg Ser Ser Ala Ala Trp Asn Met Thr 
65                  70                  75                  80  


Leu Leu Asp Gln Leu His Thr Gly Leu His Gln Gln Leu Gln His Leu 
                85                  90                  95      


Glu Thr Cys Leu Leu Gln Val Val Gly Glu Gly Glu Ser Ala Gly Ala 
            100                 105                 110         


Ile Ser Ser Pro Ala Leu Thr Leu Arg Arg Tyr Phe Gln Gly Ile Arg 
        115                 120                 125             


Val Tyr Leu Lys Glu Lys Lys Tyr Ser Asp Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Met Glu Ile Met Lys Ser Leu Phe Leu Ser Thr Asn Met Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Ser Lys Asp Arg Asp Leu Gly Ser Ser 
                165                 170         


<210>  2
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Asp Leu Pro Gln Asn His Gly Leu Leu Ser Arg Asn Thr Leu Val 
1               5                   10                  15      


Leu Leu His Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Arg Phe Pro Gln Glu Met Val Lys Gly Ser Gln Leu 
        35                  40                  45              


Gln Lys Ala His Val Met Ser Val Leu His Glu Met Leu Gln Gln Ile 
    50                  55                  60                  


Phe Ser Leu Phe His Thr Glu Arg Ser Ser Ala Ala Trp Asn Met Glu 
65                  70                  75                  80  


Leu Leu Asp Gln Leu His Thr Gly Leu His Gln Gln Leu Gln His Leu 
                85                  90                  95      


Glu Thr Cys Leu Leu Gln Val Val Gly Glu Gly Glu Ser Ala Gly Ala 
            100                 105                 110         


Ile Ser Ser Pro Ala Leu Thr Leu Arg Arg Tyr Phe Gln Gly Ile Arg 
        115                 120                 125             


Val Tyr Leu Lys Glu Lys Lys Tyr Ser Asp Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Met Glu Ile Met Lys Ser Leu Phe Leu Ser Thr Asn Met Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Ser Lys Asp Arg Asp Leu Gly Ser Ser 
                165                 170         


<210>  3
<211>  177
<212>  PRT
<213>  Pan troglodytes

<400>  3

Cys Asp Leu Pro Gln Asn His Gly Leu Leu Ser Arg Asn Thr Leu Val 
1               5                   10                  15      


Leu Leu His Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Arg Phe Pro Gln Glu Met Val Lys Gly Ser Gln Leu 
        35                  40                  45              


Gln Lys Ala Gln Val Met Ser Val Leu His Glu Met Leu Gln Gln Ile 
    50                  55                  60                  


Phe Ser Leu Phe His Thr Glu Arg Ser Ser Ala Ala Trp Asn Met Thr 
65                  70                  75                  80  


Leu Leu Asp Gln Leu His Thr Gly Leu His Gln Gln Leu Gln His Leu 
                85                  90                  95      


Glu Thr Cys Leu Leu Gln Val Met Gly Glu Gly Glu Ser Ala Gly Ala 
            100                 105                 110         


Ile Ser Ser Pro Ala Leu Thr Leu Arg Arg Tyr Phe Gln Gly Ile Arg 
        115                 120                 125             


Val Tyr Leu Lys Glu Lys Lys Tyr Ser Asp Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Met Glu Ile Met Lys Ser Leu Phe Leu Ser Thr Asn Met Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Ser Lys Asp Arg Asp Leu Gly Ser Ser Arg Asn Asp Ser 
                165                 170                 175     


His 
    


<210>  4
<211>  172
<212>  PRT
<213>  Macaca fascicularis

<400>  4

Cys Asp Leu Pro Gln Asn His Gly Leu Leu Ser Arg Asn Thr Leu Val 
1               5                   10                  15      


Leu Leu His Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Arg Phe Pro Gln Glu Met Val Glu Gly Ser Gln Leu 
        35                  40                  45              


Gln Lys Ala Gln Val Met Ser Val Leu His Glu Met Leu Gln Gln Ile 
    50                  55                  60                  


Phe Ser Leu Phe His Thr Glu His Ser Ser Ala Ala Trp Asn Thr Thr 
65                  70                  75                  80  


Leu Leu Asp His Leu His Thr Gly Leu His Arg Gln Leu Glu His Leu 
                85                  90                  95      


Glu Thr Cys Leu Val Gln Val Met Arg Glu Gly Glu Ser Ala Gly Ala 
            100                 105                 110         


Ile Arg Ser Pro Ala Leu Thr Leu Arg Arg Tyr Phe Gln Gly Ile Arg 
        115                 120                 125             


Val Tyr Leu Lys Glu Lys Lys Tyr Ser Asp Cys Ala Trp Val Val Val 
    130                 135                 140                 


Arg Met Glu Ile Met Lys Ser Leu Phe Leu Ser Thr Asn Met Gln Glu 
145                 150                 155                 160 


Arg Leu Lys Ser Lys Asp Gly Asp Leu Gly Ser Ser 
                165                 170         


<210>  5
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  5

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  6
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Glu Phe Pro Gln Glu Glu Phe Asp Asp Lys Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Leu Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Glu Phe Tyr Ile Glu Leu Asp Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ser Cys Val Met Gln Glu Val Gly Val Ile Glu Ser Pro Leu Met 
            100                 105                 110         


Tyr Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Ser Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Ile Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Lys Ser Lys Glu 
                165     


<210>  7
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Gly Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Arg Ile Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Glu Asp Ser Ser Ala Ala Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Ile Glu Arg Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Asp 
                165     


<210>  8
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Asp Leu Pro Glu Thr His Ser Leu Asp Asn Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Ser Arg Ile Ser Pro Ser Ser Cys Leu Met Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Pro Ala Ile Ser Val Leu His Glu Leu Ile Gln Gln Ile 
    50                  55                  60                  


Phe Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Asp 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Glu Arg Val Gly Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Val Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Arg Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Leu Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  9
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  9

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Thr Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Asn Gln Gln Leu Asn Asp Met 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Val Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Lys Ile Phe Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  10
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Asp Leu Pro Gln Thr His Ser Leu Ser Asn Arg Arg Thr Leu Met 
1               5                   10                  15      


Ile Met Ala Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Thr Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Met Met Gln Glu Val Gly Val Glu Asp Thr Pro Leu Met 
            100                 105                 110         


Asn Val Asp Ser Ile Leu Thr Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Ala Asn Leu Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  11
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Asn Leu Ser Gln Thr His Ser Leu Asn Asn Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Met Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Glu Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Met Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asn Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Tyr Ile Glu Leu Phe Gln Gln Met Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Met Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Asp 
                165     


<210>  12
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Leu Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Thr Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Glu Asp Ser Ser Ala Ala Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Tyr Gln Gln Leu Asn Asn Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Met Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Ile Leu Arg Arg Lys Asp 
                165     


<210>  13
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Asp Leu Pro Gln Thr His Ser Leu Arg Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Glu Phe Arg Phe Pro Glu Glu Glu Phe Asp Gly His Gln Phe 
        35                  40                  45              


Gln Lys Thr Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Glu Asp Ser Ser Ala Ala Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Phe Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Met Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Phe Ser Thr Asn Leu Lys Lys 
145                 150                 155                 160 


Gly Leu Arg Arg Lys Asp 
                165     


<210>  14
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Asp Leu Pro Gln Thr His Ser Leu Gly His Arg Arg Thr Met Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Arg Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Glu Ala Ile Ser Val Leu His Glu Val Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Val Ala Trp Asp Glu Arg 
65                  70                  75                  80  


Leu Leu Asp Lys Leu Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Val Trp Val Gly Gly Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  15
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser His Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Glu Glu Glu Phe Asp Gly His Gln Phe 
        35                  40                  45              


Gln Lys Thr Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Glu Asp Ser Ser Ala Ala Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Val Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Asp 
                165     


<210>  16
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser His Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Tyr Asp Phe Gly Phe Pro Gln Glu Val Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Ala Phe His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Tyr Ile Glu Leu Phe Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu Glu Ile Ala Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Met Gly Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Gly Leu Arg Arg Lys Asp 
                165     


<210>  17
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  17

Met Ala Leu Thr Phe Tyr Leu Leu Val Ala Leu Val Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Phe Ser Ser Leu Gly 
            20              


<210>  18
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  18

Met Ala Arg Ser Phe Ser Leu Leu Met Val Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly 
            20              


<210>  19
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  19

Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Asp 
            20              


<210>  20
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  20

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly 
            20              


<210>  21
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  21

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly 
            20              


<210>  22
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln 
1               5                   10                  15      


Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu 
            20                  25                  30          


Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln 
        35                  40                  45              


Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln 
    50                  55                  60                  


Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn 
65                  70                  75                  80  


Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn 
                85                  90                  95      


His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr 
            100                 105                 110         


Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg 
        115                 120                 125             


Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr 
    130                 135                 140                 


Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu 
145                 150                 155                 160 


Thr Gly Tyr Leu Arg Asn 
                165     


<210>  23
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Trp Gly Ser Tyr Tyr Ala Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  24
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Phe Asp Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  25
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Leu Glu Tyr Ala Phe Pro Asp Lys Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  123
<212>  PRT
<213>  Mus musculus

<400>  27

Glu Val Gln Leu Gln Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Asp Trp Val 
        35                  40                  45              


Ser Ile Ile Thr Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ala Glu Gly Gly Gly Asn Tyr Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  28
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  28

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Ile Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ala Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  29

Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Asn Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Trp Val Val Ala Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  30
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  30

Asp Ile Val Leu Thr Gln Ser Pro Val Ile Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Thr Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
            260                 265                 270         


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
        275                 280                 285             


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
    290                 295                 300                 


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
                325                 330                 335     


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
            340                 345                 350         


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
        355                 360                 365             


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
    370                 375                 380                 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
385                 390                 395                 400 


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
                405                 410                 415     


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
            420                 425                 430         


Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe 
        435                 440                 445             


Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile 
    450                 455                 460                 


Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
465                 470                 475                 480 


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
                485                 490                 495     


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala 
            500                 505                 510         


Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser 
        515                 520                 525             


Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser 
    530                 535                 540                 


Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val 
545                 550                 555         


<210>  32
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val 
1               5                   10                  15      


Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro 
            20                  25                  30          


Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe 
        35                  40                  45              


Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr 
    50                  55                  60                  


His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys 
65                  70                  75                  80  


Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr 
                85                  90                  95      


Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly 
            100                 105                 110         


Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu 
        115                 120                 125             


Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe 
    130                 135                 140                 


Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu 
145                 150                 155                 160 


Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly 
                165                 170                 175     


Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn 
            180                 185                 190         


Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val 
        195                 200                 205             


Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro 
    210                 215                 220                 


Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu 
225                 230                 235                 240 


Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val 
                245                 250                 255     


Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu 
            260                 265                 270         


Arg Asn Ser Leu Pro Lys Val Leu Arg Gln Gly Leu Ala Lys Gly Trp 
        275                 280                 285             


Asn Ala Val Ala Ile His Arg Cys Ser His Asn Ala Leu Gln Ser Glu 
    290                 295                 300                 


Thr Pro Glu Leu Lys Gln Ser Ser Cys Leu Ser Phe Pro Ser Ser Trp 
305                 310                 315                 320 


Asp Tyr Lys Arg Ala Ser Leu Cys Pro Ser Asp 
                325                 330     


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 fragment of M43 antibody

<400>  33

Gly Gly Thr Phe 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of IFNalpha

<400>  34

Asp Arg His Asp 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of IFNomega

<400>  35

Asp Arg Arg Asp 
1               


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of IFNa


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is any amino acid

<400>  36

Tyr Leu Xaa Glu Lys 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of IFNw

<400>  37

Tyr Leu Lys Glu Lys 
1               5   


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M88 LCDR1 fragment

<400>  38

Ser Gln Ser Ile Ser Ser Tyr Leu 
1               5               


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M43extendedLCDR1

<400>  39

Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 library


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X1 is any amino acid

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X2 is any amino acid

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X3 is any amino acid

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X4 is any amino acid

<400>  40

Ser Gln Ser Val Leu Xaa Ser Xaa Xaa Asn Xaa Asn Tyr Leu 
1               5                   10                  


