                         SEQUENCE LISTING

<110>  MODERNA THERAPEUTICS, INC.
 
<120>  FORMULATION AND DELIVERY OF MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND 
       NUCLEIC ACID COMPOSITIONS

<130>  M030.20/2030.1030PCT

<140>  PCT/US2014/XXXXXX
<141>  2014-03-14

<150>  US 61/782,716
<151>  2013-03-14

<150>  US 61/821,406
<151>  2013-05-09

<150>  US 61/840,510
<151>  2013-06-28

<150>  US 61/877,485
<151>  2013-09-13

<150>  US 61/942,894
<151>  2014-02-21

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  1
atggctggac ctgccaccca gagccccatg aagctgatgg ccctgcagct gctgctgtgg       60

cacagtgcac tctggacagt gcaggaagcc acccccctgg gccctgccag ctccctgccc      120

cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg      180

ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc      240

ggacactctc tgggcatccc ctgggctccc ctgagcagct gccccagcca ggccctgcag      300

ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag      360

gccctggaag ggatctcccc cgagttgggt cccaccttgg acacactgca gctggacgtc      420

gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg      480

cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg      540

gtcctggttg cctcccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac      600

cttgcccagc cctga                                                       615


<210>  2
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  2
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggct ggacctgcca cccagagccc catgaagctg atggccctgc agctgctgct      120

gtggcacagt gcactctgga cagtgcagga agccaccccc ctgggccctg ccagctccct      180

gccccagagc ttcctgctca agtgcttaga gcaagtgagg aagatccagg gcgatggcgc      240

agcgctccag gagaagctgt gtgccaccta caagctgtgc caccccgagg agctggtgct      300

gctcggacac tctctgggca tcccctgggc tcccctgagc agctgcccca gccaggccct      360

gcagctggca ggctgcttga gccaactcca tagcggcctt ttcctctacc aggggctcct      420

gcaggccctg gaagggatct cccccgagtt gggtcccacc ttggacacac tgcagctgga      480

cgtcgccgac tttgccacca ccatctggca gcagatggaa gaactgggaa tggcccctgc      540

cctgcagccc acccagggtg ccatgccggc cttcgcctct gctttccagc gccgggcagg      600

aggggtcctg gttgcctccc atctgcagag cttcctggag gtgtcgtacc gcgttctacg      660

ccaccttgcc cagccctgaa gcgctgcctt ctgcggggct tgccttctgg ccatgccctt      720

cttctctccc ttgcacctgt acctcttggt ctttgaataa agcctgagta ggaaggcggc      780

cgctcgagca tgcatctaga                                                  800


<210>  3
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  3
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggcc ggtcccgcga cccaaagccc catgaaactt atggccctgc agttgctgct      120

ttggcactcg gccctctgga cagtccaaga agcgactcct ctcggacctg cctcatcgtt      180

gccgcagtca ttccttttga agtgtctgga gcaggtgcga aagattcagg gcgatggagc      240

cgcactccaa gagaagctct gcgcgacata caaactttgc catcccgagg agctcgtact      300

gctcgggcac agcttgggga ttccctgggc tcctctctcg tcctgtccgt cgcaggcttt      360

gcagttggca gggtgccttt cccagctcca ctccggtttg ttcttgtatc agggactgct      420

gcaagccctt gagggaatct cgccagaatt gggcccgacg ctggacacgt tgcagctcga      480

cgtggcggat ttcgcaacaa ccatctggca gcagatggag gaactgggga tggcacccgc      540

gctgcagccc acgcaggggg caatgccggc ctttgcgtcc gcgtttcagc gcagggcggg      600

tggagtcctc gtagcgagcc accttcaatc atttttggaa gtctcgtacc gggtgctgag      660

acatcttgcg cagccgtgaa gcgctgcctt ctgcggggct tgccttctgg ccatgccctt      720

cttctctccc ttgcacctgt acctcttggt ctttgaataa agcctgagta ggaaggcggc      780

cgctcgagca tgcatctaga                                                  800


<210>  4
<211>  758
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  4
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gccggucccg       60

cgacccaaag ccccaugaaa cuuauggccc ugcaguugcu gcuuuggcac ucggcccucu      120

ggacagucca agaagcgacu ccucucggac cugccucauc guugccgcag ucauuccuuu      180

ugaagugucu ggagcaggug cgaaagauuc agggcgaugg agccgcacuc caagagaagc      240

ucugcgcgac auacaaacuu ugccaucccg aggagcucgu acugcucggg cacagcuugg      300

ggauucccug ggcuccucuc ucguccuguc cgucgcaggc uuugcaguug gcagggugcc      360

uuucccagcu ccacuccggu uuguucuugu aucagggacu gcugcaagcc cuugagggaa      420

ucucgccaga auugggcccg acgcuggaca cguugcagcu cgacguggcg gauuucgcaa      480

caaccaucug gcagcagaug gaggaacugg ggauggcacc cgcgcugcag cccacgcagg      540

gggcaaugcc ggccuuugcg uccgcguuuc agcgcagggc ggguggaguc cucguagcga      600

gccaccuuca aucauuuuug gaagucucgu accgggugcu gagacaucuu gcgcagccgu      660

gaagcgcugc cuucugcggg gcuugccuuc uggccaugcc cuucuucucu cccuugcacc      720

uguaccucuu ggucuuugaa uaaagccuga guaggaag                              758


<210>  5
<211>  854
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  5
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug guauccaagg       60

gggaggagga caacauggcg aucaucaagg aguucaugcg auucaaggug cacauggaag      120

guucggucaa cggacacgaa uuugaaaucg aaggagaggg ugaaggaagg cccuaugaag      180

ggacacagac cgcgaaacuc aaggucacga aagggggacc acuuccuuuc gccugggaca      240

uucuuucgcc ccaguuuaug uacgggucca aagcauaugu gaagcauccc gccgauauuc      300

cugacuaucu gaaacucagc uuucccgagg gauucaagug ggagcggguc augaacuuug      360

aggacggggg uguagucacc guaacccaag acucaagccu ccaagacggc gaguucaucu      420

acaaggucaa acugcggggg acuaacuuuc cgucggaugg gccggugaug cagaagaaaa      480

cgaugggaug ggaagcguca ucggagagga uguacccaga agauggugca uugaaggggg      540

agaucaagca gagacugaag uugaaagaug ggggacauua ugaugccgag gugaaaacga      600

cauacaaagc gaaaaagccg gugcagcuuc ccggagcgua uaaugugaau aucaaguugg      660

auauuacuuc acacaaugag gacuacacaa uugucgaaca guacgaacgc gcugagggua      720

gacacucgac gggaggcaug gacgaguugu acaaaugaua agcugccuuc ugcggggcuu      780

gccuucuggc caugcccuuc uucucucccu ugcaccugua ccucuugguc uuugaauaaa      840

gccugaguag gaag                                                        854


<210>  6
<211>  896
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  6
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggta tccaaggggg aggaggacaa catggcgatc atcaaggagt tcatgcgatt      120

caaggtgcac atggaaggtt cggtcaacgg acacgaattt gaaatcgaag gagagggtga      180

aggaaggccc tatgaaggga cacagaccgc gaaactcaag gtcacgaaag ggggaccact      240

tcctttcgcc tgggacattc tttcgcccca gtttatgtac gggtccaaag catatgtgaa      300

gcatcccgcc gatattcctg actatctgaa actcagcttt cccgagggat tcaagtggga      360

gcgggtcatg aactttgagg acgggggtgt agtcaccgta acccaagact caagcctcca      420

agacggcgag ttcatctaca aggtcaaact gcgggggact aactttccgt cggatgggcc      480

ggtgatgcag aagaaaacga tgggatggga agcgtcatcg gagaggatgt acccagaaga      540

tggtgcattg aagggggaga tcaagcagag actgaagttg aaagatgggg gacattatga      600

tgccgaggtg aaaacgacat acaaagcgaa aaagccggtg cagcttcccg gagcgtataa      660

tgtgaatatc aagttggata ttacttcaca caatgaggac tacacaattg tcgaacagta      720

cgaacgcgct gagggtagac actcgacggg aggcatggac gagttgtaca aatgataagc      780

tgccttctgc ggggcttgcc ttctggccat gcccttcttc tctcccttgc acctgtacct      840

cttggtcttt gaataaagcc tgagtaggaa ggcggccgct cgagcatgca tctaga          896


<210>  7
<211>  725
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  7
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug ggagugcacg       60

agugucccgc gugguugugg uugcugcugu cgcucuugag ccucccacug ggacugccug      120

ugcugggggc accacccaga uugaucugcg acucacgggu acuugagagg uaccuucuug      180

aagccaaaga agccgaaaac aucacaaccg gaugcgccga gcacugcucc cucaaugaga      240

acauuacugu accggauaca aaggucaauu ucuaugcaug gaagagaaug gaaguaggac      300

agcaggccgu cgaagugugg caggggcucg cgcuuuuguc ggaggcggug uugcgggguc      360

aggcccuccu cgucaacuca ucacagccgu gggagccccu ccaacuucau gucgauaaag      420

cggugucggg gcuccgcagc uugacgacgu ugcuucgggc ucugggcgca caaaaggagg      480

cuauuucgcc gccugacgcg gccuccgcgg caccccuccg aacgaucacc gcggacacgu      540

uuaggaagcu uuuuagagug uacagcaauu uccuccgcgg aaagcugaaa uuguauacug      600

gugaagcgug uaggacaggg gaucgcugau aagcugccuu cugcggggcu ugccuucugg      660

ccaugcccuu cuucucuccc uugcaccugu accucuuggu cuuugaauaa agccugagua      720

ggaag                                                                  725


<210>  8
<211>  1536
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  8
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaau gcagcgcguc       60

aacaugauua uggccgaauc gccgggacuc aucacaaucu gccucuuggg uuaucucuug      120

ucggcagaau guaccguguu cuuggaucac gaaaacgcga acaaaauucu uaaucgcccg      180

aagcgguaua acuccgggaa acuugaggag uuugugcagg gcaaucuuga acgagagugc      240

auggaggaga aaugcuccuu ugaggaggcg agggaagugu uugaaaacac agagcgaaca      300

acggaguuuu ggaagcaaua cguagauggg gaccagugug agucgaaucc gugccucaau      360

gggggaucau guaaagauga caucaauagc uaugaaugcu ggugcccguu uggguuugaa      420

gggaagaacu gugagcugga ugugacgugc aacaucaaaa acggacgcug ugagcaguuu      480

uguaagaacu cggcugacaa uaagguagua ugcucgugca cagagggaua ccggcuggcg      540

gagaaccaaa aaucgugcga gcccgcaguc ccguucccuu gugggagggu gagcguguca      600

cagacuagca aguugacgag agcggagacu guauuccccg acguggacua cgucaacagc      660

accgaagccg aaacaauccu cgauaacauc acgcagagca cucaguccuu caaugacuuu      720

acgagggucg uaggugguga ggacgcgaaa cccggucagu uccccuggca ggugguauug      780

aacggaaaag ucgaugccuu uuguggaggu uccauuguca acgagaagug gauugucaca      840

gcggcacacu gcguagaaac aggagugaaa aucacgguag uggcgggaga gcauaacauu      900

gaagagacag agcacacgga acaaaagcga aaugucauca gaaucauucc acaccauaac      960

uauaacgcgg caaucaauaa guacaaucac gacaucgcac uuuuggagcu ugacgaaccu     1020

uuggugcuua auucguacgu caccccuauu uguauugccg acaaagagua uacaaacauc     1080

uucuugaaau ucggcuccgg guacguaucg ggcuggggca gaguguucca uaaggguaga     1140

uccgcacugg uguugcaaua ccucagggug ccccucgugg aucgagccac uugucugcgg     1200

uccaccaaau ucacaaucua caacaauaug uucugugcgg gauuccauga aggugggaga     1260

gauagcugcc agggagacuc aggggguccc cacgugacgg aagucgaggg gacgucauuu     1320

cugacgggaa uuaucucaug gggagaggaa ugugcgauga aggggaaaua uggcaucuac     1380

acuaaagugu cacgguaugu caauuggauc aaggaaaaga cgaaacucac gugaucagcc     1440

agcgcugccu ucugcggggc uugccuucug gccaugcccu ucuucucucc cuugcaccug     1500

uaccucuugg ucuuugaaua aagccugagu aggaag                               1536


<210>  9
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  9
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggga gtgcacgagt gtcccgcgtg gttgtggttg ctgctgtcgc tcttgagcct      120

cccactggga ctgcctgtgc tgggggcacc acccagattg atctgcgact cacgggtact      180

tgagaggtac cttcttgaag ccaaagaagc cgaaaacatc acaaccggat gcgccgagca      240

ctgctccctc aatgagaaca ttactgtacc ggatacaaag gtcaatttct atgcatggaa      300

gagaatggaa gtaggacagc aggccgtcga agtgtggcag gggctcgcgc ttttgtcgga      360

ggcggtgttg cggggtcagg ccctcctcgt caactcatca cagccgtggg agcccctcca      420

acttcatgtc gataaagcgg tgtcggggct ccgcagcttg acgacgttgc ttcgggctct      480

gggcgcacaa aaggaggcta tttcgccgcc tgacgcggcc tccgcggcac ccctccgaac      540

gatcaccgcg gacacgttta ggaagctttt tagagtgtac agcaatttcc tccgcggaaa      600

gctgaaattg tatactggtg aagcgtgtag gacaggggat cgctgataag ctgccttctg      660

cggggcttgc cttctggcca tgcccttctt ctctcccttg cacctgtacc tcttggtctt      720

tgaataaagc ctgagtagga aggcggccgc tcgagcatgc atctaga                    767


<210>  10
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  10
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggga gtgcacgagt gtcccgcgtg gttgtggttg ctgctgtcgc tcttgagcct      120

cccactggga ctgcctgtgc tgggggcacc acccagattg atctgcgact cacgggtact      180

tgagaggtac cttcttgaag ccaaagaagc cgaaaacatc acaaccggat gcgccgagca      240

ctgctccctc aatgagaaca ttactgtacc ggatacaaag gtcaatttct atgcatggaa      300

gagaatggaa gtaggacagc aggccgtcga agtgtggcag gggctcgcgc ttttgtcgga      360

ggcggtgttg cggggtcagg ccctcctcgt caactcatca cagccgtggg agcccctcca      420

acttcatgtc gataaagcgg tgtcggggct ccgcagcttg acgacgttgc ttcgggctct      480

gggcgcacaa aaggaggcta tttcgccgcc tgacgcggcc tccgcggcac ccctccgaac      540

gatcaccgcg gacacgttta ggaagctttt tagagtgtac agcaatttcc tccgcggaaa      600

gctgaaattg tatactggtg aagcgtgtag gacaggggat cgctgataag ctgccttctg      660

cggggcttgc cttctggcca tgcccttctt ctctcccttg cacctgtacc tcttggtctt      720

tgaataaagc ctgagtagga aggcggccgc                                       750


<210>  11
<211>  1578
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  11
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccaatgca gcgcgtcaac atgattatgg ccgaatcgcc gggactcatc acaatctgcc      120

tcttgggtta tctcttgtcg gcagaatgta ccgtgttctt ggatcacgaa aacgcgaaca      180

aaattcttaa tcgcccgaag cggtataact ccgggaaact tgaggagttt gtgcagggca      240

atcttgaacg agagtgcatg gaggagaaat gctcctttga ggaggcgagg gaagtgtttg      300

aaaacacaga gcgaacaacg gagttttgga agcaatacgt agatggggac cagtgtgagt      360

cgaatccgtg cctcaatggg ggatcatgta aagatgacat caatagctat gaatgctggt      420

gcccgtttgg gtttgaaggg aagaactgtg agctggatgt gacgtgcaac atcaaaaacg      480

gacgctgtga gcagttttgt aagaactcgg ctgacaataa ggtagtatgc tcgtgcacag      540

agggataccg gctggcggag aaccaaaaat cgtgcgagcc cgcagtcccg ttcccttgtg      600

ggagggtgag cgtgtcacag actagcaagt tgacgagagc ggagactgta ttccccgacg      660

tggactacgt caacagcacc gaagccgaaa caatcctcga taacatcacg cagagcactc      720

agtccttcaa tgactttacg agggtcgtag gtggtgagga cgcgaaaccc ggtcagttcc      780

cctggcaggt ggtattgaac ggaaaagtcg atgccttttg tggaggttcc attgtcaacg      840

agaagtggat tgtcacagcg gcacactgcg tagaaacagg agtgaaaatc acggtagtgg      900

cgggagagca taacattgaa gagacagagc acacggaaca aaagcgaaat gtcatcagaa      960

tcattccaca ccataactat aacgcggcaa tcaataagta caatcacgac atcgcacttt     1020

tggagcttga cgaacctttg gtgcttaatt cgtacgtcac ccctatttgt attgccgaca     1080

aagagtatac aaacatcttc ttgaaattcg gctccgggta cgtatcgggc tggggcagag     1140

tgttccataa gggtagatcc gcactggtgt tgcaatacct cagggtgccc ctcgtggatc     1200

gagccacttg tctgcggtcc accaaattca caatctacaa caatatgttc tgtgcgggat     1260

tccatgaagg tgggagagat agctgccagg gagactcagg gggtccccac gtgacggaag     1320

tcgaggggac gtcatttctg acgggaatta tctcatgggg agaggaatgt gcgatgaagg     1380

ggaaatatgg catctacact aaagtgtcac ggtatgtcaa ttggatcaag gaaaagacga     1440

aactcacgtg atcagccagc gctgccttct gcggggcttg ccttctggcc atgcccttct     1500

tctctccctt gcacctgtac ctcttggtct ttgaataaag cctgagtagg aaggcggccg     1560

ctcgagcatg catctaga                                                   1578


<210>  12
<211>  848
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  12
aaauaagaga gaaaagaaga guaagaagaa auauaagagc caccauggug agcaagggcg       60

aggaggauaa cauggccauc aucaaggagu ucaugcgcuu caaggugcac auggagggcu      120

ccgugaacgg ccacgaguuc gagaucgagg gcgagggcga gggccgcccc uacgagggca      180

cccagaccgc caagcugaag gugaccaagg guggcccccu gcccuucgcc ugggacaucc      240

uguccccuca guucauguac ggcuccaagg ccuacgugaa gcaccccgcc gacauccccg      300

acuacuugaa gcuguccuuc cccgagggcu ucaaguggga gcgcgugaug aacuucgagg      360

acggcggcgu ggugaccgug acccaggacu ccucccugca ggacggcgag uucaucuaca      420

aggugaagcu gcgcggcacc aacuuccccu ccgacggccc cguaaugcag aagaagacca      480

ugggcuggga ggccuccucc gagcggaugu accccgagga cggcgcccug aagggcgaga      540

ucaagcagag gcugaagcug aaggacggcg gccacuacga cgcugagguc aagaccaccu      600

acaaggccaa gaagcccgug cagcugcccg gcgccuacaa cgucaacauc aaguuggaca      660

ucaccuccca caacgaggac uacaccaucg uggaacagua cgaacgcgcc gagggccgcc      720

acuccaccgg cggcauggac gagcuguaca agugagcugc cuucugcggg gcuugccuuc      780

uggccaugcc cuucuucucu cccuugcacc uguaccucuu ggucuuugaa uaaagccuga      840

guaggaag                                                               848


<210>  13
<211>  1838
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  13
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggaa gatgcgaaga acatcaagaa gggacctgcc ccgttttacc ctttggagga      120

cggtacagca ggagaacagc tccacaaggc gatgaaacgc tacgccctgg tccccggaac      180

gattgcgttt accgatgcac atattgaggt agacatcaca tacgcagaat acttcgaaat      240

gtcggtgagg ctggcggaag cgatgaagag atatggtctt aacactaatc accgcatcgt      300

ggtgtgttcg gagaactcat tgcagttttt catgccggtc cttggagcac ttttcatcgg      360

ggtcgcagtc gcgccagcga acgacatcta caatgagcgg gaactcttga atagcatggg      420

aatctcccag ccgacggtcg tgtttgtctc caaaaagggg ctgcagaaaa tcctcaacgt      480

gcagaagaag ctccccatta ttcaaaagat catcattatg gatagcaaga cagattacca      540

agggttccag tcgatgtata cctttgtgac atcgcatttg ccgccagggt ttaacgagta      600

tgacttcgtc cccgagtcat ttgacagaga taaaaccatc gcgctgatta tgaattcctc      660

gggtagcacc ggtttgccaa agggggtggc gttgccccac cgcactgctt gtgtgcggtt      720

ctcgcacgct agggatccta tctttggtaa tcagatcatt cccgacacag caatcctgtc      780

cgtggtacct tttcatcacg gttttggcat gttcacgact ctcggctatt tgatttgcgg      840

tttcagggtc gtacttatgt atcggttcga ggaagaactg tttttgagat ccttgcaaga      900

ttacaagatc cagtcggccc tccttgtgcc aacgcttttc tcattctttg cgaaatcgac      960

acttattgat aagtatgacc tttccaatct gcatgagatt gcctcagggg gagcgccgct     1020

tagcaaggaa gtcggggagg cagtggccaa gcgcttccac cttcccggaa ttcggcaggg     1080

atacgggctc acggagacaa catccgcgat ccttatcacg cccgagggtg acgataagcc     1140

gggagccgtc ggaaaagtgg tccccttctt tgaagccaag gtcgtagacc tcgacacggg     1200

aaaaaccctc ggagtgaacc agaggggcga gctctgcgtg agagggccga tgatcatgtc     1260

aggttacgtg aataaccctg aagcgacgaa tgcgctgatc gacaaggatg ggtggttgca     1320

ttcgggagac attgcctatt gggatgagga tgagcacttc tttatcgtag atcgacttaa     1380

gagcttgatc aaatacaaag gctatcaggt agcgcctgcc gagctcgagt caatcctgct     1440

ccagcacccc aacattttcg acgccggagt ggccgggttg cccgatgacg acgcgggtga     1500

gctgccagcg gccgtggtag tcctcgaaca tgggaaaaca atgaccgaaa aggagatcgt     1560

ggactacgta gcatcacaag tgacgactgc gaagaaactg aggggagggg tagtctttgt     1620

ggacgaggtc ccgaaaggct tgactgggaa gcttgacgct cgcaaaatcc gggaaatcct     1680

gattaaggca aagaaaggcg ggaaaatcgc tgtctgataa gctgccttct gcggggcttg     1740

ccttctggcc atgcccttct tctctccctt gcacctgtac ctcttggtct ttgaataaag     1800

cctgagtagg aaggcggccg ctcgagcatg catctaga                             1838


<210>  14
<211>  1796
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  14
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gaagaugcga       60

agaacaucaa gaagggaccu gccccguuuu acccuuugga ggacgguaca gcaggagaac      120

agcuccacaa ggcgaugaaa cgcuacgccc ugguccccgg aacgauugcg uuuaccgaug      180

cacauauuga gguagacauc acauacgcag aauacuucga aaugucggug aggcuggcgg      240

aagcgaugaa gagauauggu cuuaacacua aucaccgcau cguggugugu ucggagaacu      300

cauugcaguu uuucaugccg guccuuggag cacuuuucau cggggucgca gucgcgccag      360

cgaacgacau cuacaaugag cgggaacucu ugaauagcau gggaaucucc cagccgacgg      420

ucguguuugu cuccaaaaag gggcugcaga aaauccucaa cgugcagaag aagcucccca      480

uuauucaaaa gaucaucauu auggauagca agacagauua ccaaggguuc cagucgaugu      540

auaccuuugu gacaucgcau uugccgccag gguuuaacga guaugacuuc guccccgagu      600

cauuugacag agauaaaacc aucgcgcuga uuaugaauuc cucggguagc accgguuugc      660

caaagggggu ggcguugccc caccgcacug cuugugugcg guucucgcac gcuagggauc      720

cuaucuuugg uaaucagauc auucccgaca cagcaauccu guccguggua ccuuuucauc      780

acgguuuugg cauguucacg acucucggcu auuugauuug cgguuucagg gucguacuua      840

uguaucgguu cgaggaagaa cuguuuuuga gauccuugca agauuacaag auccagucgg      900

cccuccuugu gccaacgcuu uucucauucu uugcgaaauc gacacuuauu gauaaguaug      960

accuuuccaa ucugcaugag auugccucag ggggagcgcc gcuuagcaag gaagucgggg     1020

aggcaguggc caagcgcuuc caccuucccg gaauucggca gggauacggg cucacggaga     1080

caacauccgc gauccuuauc acgcccgagg gugacgauaa gccgggagcc gucggaaaag     1140

ugguccccuu cuuugaagcc aaggucguag accucgacac gggaaaaacc cucggaguga     1200

accagagggg cgagcucugc gugagagggc cgaugaucau gucagguuac gugaauaacc     1260

cugaagcgac gaaugcgcug aucgacaagg augggugguu gcauucggga gacauugccu     1320

auugggauga ggaugagcac uucuuuaucg uagaucgacu uaagagcuug aucaaauaca     1380

aaggcuauca gguagcgccu gccgagcucg agucaauccu gcuccagcac cccaacauuu     1440

ucgacgccgg aguggccggg uugcccgaug acgacgcggg ugagcugcca gcggccgugg     1500

uaguccucga acaugggaaa acaaugaccg aaaaggagau cguggacuac guagcaucac     1560

aagugacgac ugcgaagaaa cugaggggag ggguagucuu uguggacgag gucccgaaag     1620

gcuugacugg gaagcuugac gcucgcaaaa uccgggaaau ccugauuaag gcaaagaaag     1680

gcgggaaaau cgcugucuga uaagcugccu ucugcggggc uugccuucug gccaugcccu     1740

ucuucucucc cuugcaccug uaccucuugg ucuuugaaua aagccugagu aggaag         1796


<210>  15
<211>  902
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  15
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct      120

ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac      180

ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc      240

caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc ccgaccacat      300

gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat      360

cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac      420

cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg      480

gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg acaagcagaa      540

gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca gcgtgcagct      600

cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa      660

ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat      720

ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa      780

gtaagctgcc ttctgcgggg cttgccttct ggccatgccc ttcttctctc ccttgcacct      840

gtacctcttg gtctttgaat aaagcctgag taggaaggcg gccgctcgag catgcatcta      900

ga                                                                     902


<210>  16
<211>  863
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  16
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug guguccaagg       60

gugaggaauu guuuaccggg guggugccua uucucgucga acuugacggg gaugugaaug      120

gacacaaguu uucgguaucc ggagaaggag agggugacgc cacauacgga aagcuuacac      180

ucaaauucau cuguacgacg gggaaacugc ccguacccug gccuacgcuc guaaccacgc      240

ugacuuaugg agugcagugc uuuagcagau accccgacca uaugaagcag cacgacuucu      300

ucaagucggc gaugcccgag ggguacgugc aagagaggac cauuuucuuc aaagacgaug      360

gcaauuacaa aacacgcgca gaagucaagu uugagggcga uacucugguc aaucggaucg      420

aauugaaggg aaucgauuuc aaagaagaug gaaacauccu uggccauaag cucgaguaca      480

acuauaacuc gcauaauguc uauaucaugg cugacaagca gaaaaacggu aucaaaguca      540

acuuuaagau ccgacacaau auugaggacg guucggugca gcuugcggac cacuaucaac      600

agaauacgcc gauuggggau gguccggucc uuuugccgga uaaccauuau cucucaaccc      660

agucagcccu gagcaaagau ccaaacgaga agagggacca cauggucuug cucgaauucg      720

ugacagcggc agggaucacu cugggaaugg acgaguugua caagugauaa gcugccuucu      780

gcggggcuug ccuucuggcc augcccuucu ucucucccuu gcaccuguac cucuuggucu      840

uugaauaaag ccugaguagg aag                                              863


<210>  17
<211>  716
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Descrption of Artificial Sequence: Synthetic transcript sequence

<400>  17
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug aacuuucucu       60

ugucaugggu gcacuggagc cuugcgcugc ugcuguaucu ucaucacgcu aaguggagcc      120

aggccgcacc cauggcggag gguggcggac agaaucacca cgaaguaguc aaauucaugg      180

acguguacca gaggucguau ugccauccga uugaaacucu uguggauauc uuucaagaau      240

accccgauga aaucgaguac auuuucaaac cgucgugugu cccucucaug aggugcgggg      300

gaugcugcaa ugaugaaggg uuggagugug uccccacgga ggagucgaau aucacaaugc      360

aaaucaugcg caucaaacca caucaggguc agcauauugg agagaugucc uuucuccagc      420

acaacaaaug ugaguguaga ccgaagaagg accgagcccg acaggaaaac ccaugcggac      480

cgugcuccga gcggcgcaaa cacuuguucg uacaagaccc ccagacaugc aagugcucau      540

guaagaauac cgauucgcgg uguaaggcga gacagcugga auugaacgag cgcacgugua      600

ggugcgacaa gccuagacgg ugagcugccu ucugcggggc uugccuucug gccaugcccu      660

ucuucucucc cuugcaccug uaccucuugg ucuuugaaua aagccugagu aggaag          716


<210>  18
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  18
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatgaac tttctcttgt catgggtgca ctggagcctt gcgctgctgc tgtatcttca      120

tcacgctaag tggagccagg ccgcacccat ggcggagggt ggcggacaga atcaccacga      180

agtagtcaaa ttcatggacg tgtaccagag gtcgtattgc catccgattg aaactcttgt      240

ggatatcttt caagaatacc ccgatgaaat cgagtacatt ttcaaaccgt cgtgtgtccc      300

tctcatgagg tgcgggggat gctgcaatga tgaagggttg gagtgtgtcc ccacggagga      360

gtcgaatatc acaatgcaaa tcatgcgcat caaaccacat cagggtcagc atattggaga      420

gatgtccttt ctccagcaca acaaatgtga gtgtagaccg aagaaggacc gagcccgaca      480

ggaaaaccca tgcggaccgt gctccgagcg gcgcaaacac ttgttcgtac aagaccccca      540

gacatgcaag tgctcatgta agaataccga ttcgcggtgt aaggcgagac agctggaatt      600

gaacgagcgc acgtgtaggt gcgacaagcc tagacggtga gctgccttct gcggggcttg      660

ccttctggcc atgcccttct tctctccctt gcacctgtac ctcttggtct ttgaataaag      720

cctgagtagg aaggcggccg ctcgagcatg catctaga                              758


<210>  19
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala 
            20                  25                  30  


<210>  20
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu 
1               5                   10                  15      


Cys Cys Leu Val Pro Val Ser Leu Ala 
            20                  25  


<210>  21
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Ser Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg 
        35                  40                  45      


<210>  22
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Gly Ser Leu Leu Leu Leu Leu Val Ser Asn Leu Leu Leu Cys 
1               5                   10                  15      


Gln Ser Val Ala Pro 
            20      


<210>  23
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg 
            20                  


<210>  24
<211>  793
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  24
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gacucggacg       60

agaccggguu cgagcacuca ggacuguggg uuucugugcu ggcuggucuu cugcugggag      120

ccugccaggc acaccccauc ccugacucca guccucuccu gcaauucggg ggccaagucc      180

ggcagcggua ccucuacaca gaugaugccc agcagacaga agcccaccug gagaucaggg      240

aggaugggac gguggggggc gcugcugacc agagccccga aagucuccug cagcugaaag      300

ccuugaagcc gggaguuauu caaaucuugg gagucaagac auccagguuc cugugccagc      360

ggccagaugg ggcccuguau ggaucgcucc acuuugaccc ugaggccugc agcuuccggg      420

agcugcuucu ugaggacgga uacaauguuu accaguccga agcccacggc cucccgcugc      480

accugccagg gaacaagucc ccacaccggg acccugcacc ccgaggacca gcucgcuucc      540

ugccacuacc aggccugccc cccgcacccc cggagccacc cggaauccug gccccccagc      600

cccccgaugu gggcuccucg gacccucuga gcaugguggg accuucccag ggccgaagcc      660

ccagcuacgc uuccugauaa uaggcuggag ccucgguggc caugcuucuu gccccuuggg      720

ccucccccca gccccuccuc cccuuccugc acccguaccc ccguggucuu ugaauaaagu      780

cugagugggc ggc                                                         793


<210>  25
<211>  761
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  25
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug ggggugcccg       60

aacgucccac ccugcugcuu uuacucuccu ugcuacugau uccucugggc cucccagucc      120

ucugugcucc cccacgccuc aucugcgaca gucgaguucu ggagagguac aucuuagagg      180

ccaaggaggc agaaaauguc acgauggguu gugcagaagg ucccagacug agugaaaaua      240

uuacaguccc agauaccaaa gucaacuucu augcuuggaa aagaauggag guggaagaac      300

aggccauaga aguuuggcaa ggccuguccc ugcucucaga agccauccug caggcccagg      360

cccugcuagc caauuccucc cagccaccag agacccuuca gcuucauaua gacaaagcca      420

ucaguggucu acguagccuc acuucacugc uucggguacu gggagcucag aaggaauuga      480

ugucgccucc agauaccacc ccaccugcuc cacuccgaac acucacagug gauacuuucu      540

gcaagcucuu ccgggucuac gccaacuucc uccgggggaa acugaagcug uacacgggag      600

aggucugcag gagaggggac aggugauaau aggagccucg guggccaugc uucuugcccc      660

uugggccucc ccccagcccc uccuccccuu ccugcacccg uacccccucc auaaaguagg      720

aaacacuaca guggucuuug aauaaagucu gagugggcgg c                          761


<210>  26
<211>  742
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  26
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug ggggugcccg       60

aacgucccac ccugcugcuu uuacucuccu ugcuacugau uccucugggc cucccagucc      120

ucugugcucc cccacgccuc aucugcgaca gucgaguucu ggagagguac aucuuagagg      180

ccaaggaggc agaaaauguc acgauggguu gugcagaagg ucccagacug agugaaaaua      240

uuacaguccc agauaccaaa gucaacuucu augcuuggaa aagaauggag guggaagaac      300

aggccauaga aguuuggcaa ggccuguccc ugcucucaga agccauccug caggcccagg      360

cccugcuagc caauuccucc cagccaccag agacccuuca gcuucauaua gacaaagcca      420

ucaguggucu acguagccuc acuucacugc uucggguacu gggagcucag aaggaauuga      480

ugucgccucc agauaccacc ccaccugcuc cacuccgaac acucacagug gauacuuucu      540

gcaagcucuu ccgggucuac gccaacuucc uccgggggaa acugaagcug uacacgggag      600

aggucugcag gagaggggac aggugauaau aggcuggagc cucgguggcc augcuucuug      660

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      720

gaauaaaguc ugagugggcg gc                                               742


<210>  27
<211>  768
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  27
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug ggagugcacg       60

agugucccgc gugguugugg uugcugcugu cgcucuugag ccucccacug ggacugccug      120

ugcugggggc accacccaga uugaucugcg acucacgggu acuugagagg uaccuucuug      180

aagccaaaga agccgaaaac aucacaaccg gaugcgccga gcacugcucc cucaaugaga      240

acauuacugu accggauaca aaggucaauu ucuaugcaug gaagagaaug gaaguaggac      300

agcaggccgu cgaagugugg caggggcucg cgcuuuuguc ggaggcggug uugcgggguc      360

aggcccuccu cgucaacuca ucacagccgu gggagccccu ccaacuucau gucgauaaag      420

cggugucggg gcuccgcagc uugacgacgu ugcuucgggc ucugggcgca caaaaggagg      480

cuauuucgcc gccugacgcg gccuccgcgg caccccuccg aacgaucacc gcggacacgu      540

uuaggaagcu uuuuagagug uacagcaauu uccuccgcgg aaagcugaaa uuguauacug      600

gugaagcgug uaggacaggg gaucgcugau aauaggcugg agccucggug gccaugcuuc      660

uugccccuug ggccuccccc cagccccucc uccccuuccu gcacccguac ccccuccaua      720

aaguaggaaa cacuacagug gucuuugaau aaagucugag ugggcggc                   768


<210>  28
<211>  745
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic transcript sequence

<400>  28
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug ggagugcacg       60

agugucccgc gugguugugg uugcugcugu cgcucuugag ccucccacug ggacugccug      120

ugcugggggc accacccaga uugaucugcg acucacgggu acuugagagg uaccuucuug      180

aagccaaaga agccgaaaac aucacaaccg gaugcgccga gcacugcucc cucaaugaga      240

acauuacugu accggauaca aaggucaauu ucuaugcaug gaagagaaug gaaguaggac      300

agcaggccgu cgaagugugg caggggcucg cgcuuuuguc ggaggcggug uugcgggguc      360

aggcccuccu cgucaacuca ucacagccgu gggagccccu ccaacuucau gucgauaaag      420

cggugucggg gcuccgcagc uugacgacgu ugcuucgggc ucugggcgca caaaaggagg      480

cuauuucgcc gccugacgcg gccuccgcgg caccccuccg aacgaucacc gcggacacgu      540

uuaggaagcu uuuuagagug uacagcaauu uccuccgcgg aaagcugaaa uuguauacug      600

gugaagcgug uaggacaggg gaucgcugau aauaggcugg agccucggug gccaugcuuc      660

uugccccuug ggccuccccc cagccccucc uccccuuccu gcacccguac ccccgugguc      720

uuugaauaaa gucugagugg gcggc                                            745


