                               SEQUENCE LISTING

<110> THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120> OSTEOCALCIN AS A TREATMENT FOR COGNITIVE DISORDERS

<130> 13533/54076

<140> PCT/US2014/027404
<141> 2014-03-14

<150> 61/794,006
<151> 2013-03-15

<160> 19    

<170> PatentIn version 3.5

<210> 1
<211> 498
<212> DNA
<213> Homo sapiens

<400> 1
cgcagccacc gagacaccat gagagccctc acactcctcg ccctattggc cctggccgca       60

ctttgcatcg ctggccaggc aggtgcgaag cccagcggtg cagagtccag caaaggtgca      120

gcctttgtgt ccaagcagga gggcagcgag gtagtgaaga gacccaggcg ctacctgtat      180

caatggctgg gagccccagt cccctacccg gatcccctgg agcccaggag ggaggtgtgt      240

gagctcaatc cggactgtga cgagttggct gaccacatcg gctttcagga ggcctatcgg      300

cgcttctacg gcccggtcta gggtgtcgct ctgctggcct ggccggcaac cccagttctg      360

ctcctctcca ggcacccttc tttcctcttc cccttgccct tgccctgacc tcccagccct      420

atggatgtgg ggtccccatc atcccagctg ctcccaaata aactccagaa gaggaatctg      480

aaaaaaaaaa aaaaaaaa                                                    498


<210> 2
<211> 100
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Ala Leu Thr Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Ile Ala Gly Gln Ala Gly Ala Lys Pro Ser Gly Ala Glu Ser Ser Lys 
            20                  25                  30          


Gly Ala Ala Phe Val Ser Lys Gln Glu Gly Ser Glu Val Val Lys Arg 
        35                  40                  45              


Pro Arg Arg Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro 
    50                  55                  60                  


Asp Pro Leu Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys 
65                  70                  75                  80  


Asp Glu Leu Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe 
                85                  90                  95      


Tyr Gly Pro Val 
            100 


<210> 3
<211> 494
<212> DNA
<213> Mus musculus

<400> 3
agaacagaca agtcccacac agcagcttgg cccagaccta gcagacacca tgaggaccat       60

ctttctgctc actctgctga ccctggctgc gctctgtctc tctgacctca cagatgccaa      120

gcccagcggc cctgagtctg acaaagcctt catgtccaag caggagggca ataaggtagt      180

gaacagactc cggcgctacc ttggagcctc agtccccagc ccagatcccc tggagcccac      240

ccgggagcag tgtgagctta accctgcttg tgacgagcta tcagaccagt atggcttgaa      300

gaccgcctac aaacgcatct atggtatcac tatttaggac ctgtgctgcc ctaaagccaa      360

actctggcag ctcggctttg gctgctctcc gggacttgat cctccctgtc ctctctctct      420

gccctgcaag tatggatgtc acagcagctc caaaataaag ttcagatgag gaagtgcaaa      480

aaaaaaaaaa aaaa                                                        494


<210> 4
<211> 470
<212> DNA
<213> Mus musculus

<400> 4
gaacagacaa gtcccacaca gcagcttggt gcacacctag cagacaccat gaggaccctc       60

tctctgctca ctctgctggc cctggctgcg ctctgtctct ctgacctcac agatcccaag      120

cccagcggcc ctgagtctga caaagccttc atgtccaagc aggagggcaa taaggtagtg      180

aacagactcc ggcgctacct tggagcctca gtccccagcc cagatcccct ggagcccacc      240

cgggagcagt gtgagcttaa ccctgcttgt gacgagctat cagaccagta tggcttgaag      300

accgcctaca aacgcatcta cggtatcact atttaggacc tgtgctgccc taaagccaaa      360

ctctggcagc tcggctttgg ctgctctccg ggacttgatc ctccctgtcc tctctctctg      420

ccctgcaagt atggatgtca cagcagctcc aaaataaagt tcagatgagg                 470


<210> 5
<211> 95
<212> PRT
<213> Mus musculus

<400> 5
Met Arg Thr Leu Ser Leu Leu Thr Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Leu Ser Asp Leu Thr Asp Pro Lys Pro Ser Gly Pro Glu Ser Asp Lys 
            20                  25                  30          


Ala Phe Met Ser Lys Gln Glu Gly Asn Lys Val Val Asn Arg Leu Arg 
        35                  40                  45              


Arg Tyr Leu Gly Ala Ser Val Pro Ser Pro Asp Pro Leu Glu Pro Thr 
    50                  55                  60                  


Arg Glu Gln Cys Glu Leu Asn Pro Ala Cys Asp Glu Leu Ser Asp Gln 
65                  70                  75                  80  


Tyr Gly Leu Lys Thr Ala Tyr Lys Arg Ile Tyr Gly Ile Thr Ile 
                85                  90                  95  


<210> 6
<211> 3176
<212> DNA
<213> Homo sapiens

<400> 6
gtgacccacc tgcctcctcc gcagagcaat ggcggtgtct gccgggtccg cgcggacctc       60

gcccagctca gataaagtac agaaagacaa ggctgaactg atctcagggc ccaggcagga      120

cagccgaata gggaaactct tgggttttga gtggacagat ttgtccagtt ggcggaggct      180

ctgaatcgac caacggaccc tgcaagctta gctgtctttc gttttctttt tgggttcttg      240

atggtgctag acattcccca ggagcggggg ctcagctctc tggaccggaa gggctggatg      300

tgtgccgctt ccccttgctg gatgccctac gcccactgcc atgtatcttg tctacaccat      360

catgtttctg ggggcactgg gcatgatgct taccggataa gctgtgtgtt attcctgctg      420

ccatactggt atgtgtttct cctggacaag acatcatgga acaaccactc ctatctgtat      480

gggttgttgg cctttcagct gatgcaaacc actactggtc tgtggacggt ctgctgaatg      540

cccataggag gtgccccttt ggaactatgc agtgctccgt ggccagatct tcattgtgta      600

cttcattgcg ggtgtgaaaa agctggatgc agactgggtt gaaggctatt ccatggaata      660

tttgtcccgg cactggctct tcagtccctt caaactgctg ttgtctgagg agctgactag      720

cctgctggtc gtgcactggg gtgggctgct gcttgacctc tcagctggtt tcctgctctt      780

ttttgatgtc tcaagatcca ttggcctgtt ctttgtgtcc tacttccact gcatgaattc      840

ccagcttttc agcattggta tgttctccta cgtcatgctg gccagcagcc ctctcttctg      900

ctcccctgag tggcctcgga agctggtgtc ctactgcccc cgaaggttgc aacaactgtt      960

gcccctcaag gcagcccctc agcccagtgt ttcctgtgtg tataagagga gccggggcaa     1020

aagtggccag aagccagggc tgcgccatca gctgggagct gccttcaccc tgctctacct     1080

cctggagcag ctattcctgc cctattctca ttttctcacc cagggctata acaactggac     1140

aaatgggctg tatggctatt cctgggacat gatggtgcac tcccgctccc accagcacgt     1200

gaagatcacc taccgtgatg gccgcactgg cgaactgggc taccttaacc ctggggtatt     1260

tacacagagt cggcgatgga aggatcatgc agacatgctg aagcaatatg ccacttgcct     1320

gagccgcctg cttcccaagt ataatgtcac tgagccccag atctactttg atatttgggt     1380

ctccatcaat gaccgcttcc agcagaggat ttttgaccct cgtgtggaca tcgtgcaggc     1440

cgcttggtca ccctttcagc gcacatcctg ggtgcaacca ctcttgatgg acctgtctcc     1500

ctggagggcc aagttacagg aaatcaagag cagcctagac aaccacactg aggtggtctt     1560

cattgcagat ttccctggac tgcacttgga gaattttgtg agtgaagacc tgggcaacac     1620

tagcatccag ctgctgcagg gggaagtgac tgtggagctt gtggcagaac agaagaacca     1680

gactcttcga gagggagaaa aaatgcagtt gcctgctggt gagtaccata aggtgtatac     1740

gacatcacct agcccttctt gctacatgta cgtctatgtc aacactacag agcttgcact     1800

ggagcaagac ctggcatatc tgcaagaatt aaaggaaaag gtggagaatg gaagtgaaac     1860

agggcctcta cccccagagc tgcagcctct gttggaaggg gaagtaaaag ggggccctga     1920

gccaacacct ctggttcaga cctttcttag acgccaacaa aggctccagg agattgaacg     1980

ccggcgaaat actcctttcc atgagcgatt cttccgcttc ttgttgcgaa agctctatgt     2040

ctttcgccgc agcttcctga tgacttgtat ctcacttcga aatctgatat taggccgtcc     2100

ttccctggag cagctggccc aggaggtgac ttatgcaaac ttgagaccct ttgaggcagt     2160

tggagaactg aatccctcaa acacggattc ttcacattct aatcctcctg agtcaaatcc     2220

tgatcctgtc cactcagagt tctgaagggg gccagatgtt gggtgcagat gtagaagcag     2280

ccagtcacag acccattcta tgcaatggac atttatttga aaaaaattct caaaagtttt     2340

tttttttttt ttgggggggc ggggttctaa agctgttttt aactccgaga ttacaactta     2400

gaggaaccaa ggaaataaag caaataagat ttaacaaccc aagattaaga ggccaggaag     2460

aggttagacg caatgtgaaa ctgtcctcct aggataaggt ttaaagtggc tttttggggg     2520

ctgggtgccg tggctcacgc ctgtaatccc agcattttgg gaggctgagg tgggcagatc     2580

acttgaggcc aggagttcga gaccagcctg gccaacatgg caaaacccct tctctactaa     2640

aaatacaaaa attagccaga cgtggtggtg ggtgcctgta atccaactac ccaggaggct     2700

gaggcatgag aatcgcttgg gcccaggagg tggaggttgc agtgagccga gatcgagcca     2760

ctgcactcct gggcaacaga gcaagacttc gtctcaaaat aaataaataa agtggctctt     2820

ggggaaaagc aatttaatgt accacgatga atagctaact gttcccaagt gtttgctatg     2880

tgcaacacac cgcgtgagca gtgttacctg cattattaca ttaggctgag aggtaaaata     2940

atttgcccga agacatacag ctagtgacga atggactgat ggtttgaact taacgtctat     3000

ttgacttaag gtcctgcacc ctgccacttg taattttcag aatcactgat aatctgaaat     3060

aatgcagctt aaaacatgtt ttcttaatta aaagtataaa aaaaaaaaaa aaaaaaaaaa     3120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa         3176


<210> 7
<211> 758
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
1               5                   10                  15      


Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
            20                  25                  30          


Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
        35                  40                  45              


Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
    50                  55                  60                  


Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
65                  70                  75                  80  


Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                85                  90                  95      


Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
            100                 105                 110         


Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
        115                 120                 125             


Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
    130                 135                 140                 


Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
145                 150                 155                 160 


Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                165                 170                 175     


Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
            180                 185                 190         


Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
        195                 200                 205             


Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
    210                 215                 220                 


Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
225                 230                 235                 240 


Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                245                 250                 255     


Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
            260                 265                 270         


Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
        275                 280                 285             


Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
    290                 295                 300                 


Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
305                 310                 315                 320 


Ser Tyr Cys Pro Arg Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                325                 330                 335     


Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
            340                 345                 350         


Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
        355                 360                 365             


Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
    370                 375                 380                 


Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
385                 390                 395                 400 


Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                405                 410                 415     


Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
            420                 425                 430         


Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
        435                 440                 445             


Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
    450                 455                 460                 


Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
465                 470                 475                 480 


Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                485                 490                 495     


Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
            500                 505                 510         


Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
        515                 520                 525             


Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
    530                 535                 540                 


Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
545                 550                 555                 560 


Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                565                 570                 575     


Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
            580                 585                 590         


Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
        595                 600                 605             


Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
    610                 615                 620                 


Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
625                 630                 635                 640 


Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                645                 650                 655     


Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
            660                 665                 670         


Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
        675                 680                 685             


Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
    690                 695                 700                 


Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
705                 710                 715                 720 


Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                725                 730                 735     


Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
            740                 745                 750         


Pro Val His Ser Glu Phe 
        755             


<210> 8
<211> 2905
<212> DNA
<213> Mus musculus

<400> 8
agacagcaag tctaagtctg gaggttccac tgggtccgac ctggctgcag agaggctcac       60

ctgtccctgc agtcatggct gtgcaccgcg gctccgcact ggttgctccc gcctcagata      120

aagtacagaa aaacaagtct gcacagacat caggactgaa acagggcagc cgaatggaga      180

aaattttagg gtttgaatgg acagatttat ctagctggca gagtgtcgtg accctgctta      240

acaaaccaac ggaccctgca aacctggctg tctttcgttt tctctttgct ttcttgatgc      300

tgctggacat tccccaggaa cgcggcctta gctccctgga ccgaaaatac ttggatgggc      360

tggatgtgtg ccgtttcccc ttgctggatg ccttgcgccc actgccactg gactggatgt      420

atcttgtcta caccatcatg tttctggggg cactgggcat gatgctgggg ctatgctacc      480

ggctaagctg tgtgttattc ctgctaccgt actggtacgt gtttctcctg gacaagactt      540

cgtggaacaa tcactcctat ctgtatggtt tgttggcctt tcagttgaca ttcatggatg      600

caaaccacta ctggtctgtg gatggcttgc tgaatgcccg aaagaagaat gctcacgtgc      660

ccctttggaa ctacacagtt ctgcgtggcc agatcttcat cgtgtacttc atcgcgggtg      720

tgaagaagct cgatgctgac tgggttgggg gctactccat ggagcacctg tcccggcact      780

ggctcttcag tcccttcaag ctggtgttgt cggaggagct gacaagcctg ctggtagtac      840

actggtgtgg gcttctcctt gacctctcgg ctggcttcct gctcttcttt gatgcctcca      900

gacccgtcgg cctgttcttc gtgtcctact ttcactgcat gaactcgcag ctcttcagca      960

tcgggatgtt tccctatgtc atgctggcca gcagccctct cttctgctca gctgaatggc     1020

ctcggaagtt ggtagcccga tgcccgaaaa ggctgcaaga gctgctgccc accaaagccg     1080

ctcctcggcc tagtgcttcc tgtgtgtata agaggtcccg gggcaaagct ggcccgaagc     1140

ccgggctgcg ccaccagctg ggagccatct tcaccctgct ctacctccta gagcagctct     1200

tcctgcccta ttcccacttc ctgacccagg gttacaataa ctggacaaat gggctgtatg     1260

gctattcctg ggacatgatg gtgcactccc gctcccacca gcacgtaaag atcacctacc     1320

gcgacggcct cacgggcgag ctaggctacc ttaaccctgg ggtattcaca cagagccggc     1380

gatggaagga tcatgcagac atgctgaagc aatatgccac ttgcctgagc ctcctgcttc     1440

ccaagtacaa tgtcactgag ccccagatct actttgatat ttgggtctcc atcaatgacc     1500

gcttccagca gaggcttttt gaccctcgtg tggacatcgt gcaggctgtc tggtccccct     1560

tccagcgcac accttgggtg cagccactct tgatggattt atctccctgg aggaccaagt     1620

tacaggatat taagagcagt ctggacaacc acaccgaggt ggtcttcatt gcagatttcc     1680

ctgggcttca cttggagaat tttgtgagtg aagacctggg caacactagc atccagctgc     1740

tgcagggaga agtcaccgtg gaattggtgg cagaacagaa aaatcagact cttcaagaag     1800

gagagaaaat gcagttgcct gctggagagt accataaagt ctatactgta tcatctagtc     1860

cttcctgcta catgtacgtc tatgtcaaca ctacagaggt cgcactggag caagacctgg     1920

catatctgca agaattaaag gagaaggtgg agaacggaag tgaaacaggg cccctgcctc     1980

cagaacttca gcctcttttg gaaggggaag taaaaggggg ccctgagcca acacctctgg     2040

tccaaacttt tctcagacga cagaggaagc tccaagaaat tgaacgcagg cgaaatagcc     2100

ctttccatga gcgatttctc cgcttcgtgc tgcgaaagct ctacgtcttt cgacgcagct     2160

tcctgatgac tcgaatttca ctccgaaacc tgctattagg ccgcccttcc ctagagcaac     2220

tagcccaaga ggtgacatat gcaaacttgc gaccatttga accagttgat gagtcaagtg     2280

cttcaaacac agattcttca aatcacccgt cagagccaga ttctgagcat gttcactctg     2340

agttctgagg gatgtacaga tgctctgtgc agatgtgggg gcagcctgtt ataggcttat     2400

tgtctacgca aagaacatat ttttggagaa aaatgatatg ggacaggctt tcacagtaca     2460

gcccaggctg gcctcaaact catggttggt ccctctgctt cagcctgttt tgtaattaca     2520

tagtatcacc aaacctagtt gcttttccct ttacattttt tccccttata agttctttaa     2580

aattatagct tacatttttt cttttttctt tttttttttt ttgtattttt tctttgtcaa     2640

gacaggtctc tctctgtgta gcactggctg tcctggaact cactctgtag tccaggctgg     2700

cctccaactc agaaattctc ctgcctctgc ctcccaagtg ctgggattaa aggtgtgtgc     2760

caccacgccc cactgggctt ttagttttta tagacaagat ttctccatgt agaccagacc     2820

agctctcctg agtgctgaaa ttaaaggcac gggacatcac tacctggctt tcttattaaa     2880

cttgttttag tggtctcaac aaaaa                                           2905


<210> 9
<211> 757
<212> PRT
<213> Mus musculus

<400> 9
Met Ala Val His Arg Gly Ser Ala Leu Val Ala Pro Ala Ser Asp Lys 
1               5                   10                  15      


Val Gln Lys Asn Lys Ser Ala Gln Thr Ser Gly Leu Lys Gln Gly Ser 
            20                  25                  30          


Arg Met Glu Lys Ile Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
        35                  40                  45              


Gln Ser Val Val Thr Leu Leu Asn Lys Pro Thr Asp Pro Ala Asn Leu 
    50                  55                  60                  


Ala Val Phe Arg Phe Leu Phe Ala Phe Leu Met Leu Leu Asp Ile Pro 
65                  70                  75                  80  


Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                85                  90                  95      


Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
            100                 105                 110         


Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
        115                 120                 125             


Met Met Leu Gly Leu Cys Tyr Arg Leu Ser Cys Val Leu Phe Leu Leu 
    130                 135                 140                 


Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
145                 150                 155                 160 


Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                165                 170                 175     


Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala Arg Lys Lys Asn 
            180                 185                 190         


Ala His Val Pro Leu Trp Asn Tyr Thr Val Leu Arg Gly Gln Ile Phe 
        195                 200                 205             


Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
    210                 215                 220                 


Gly Gly Tyr Ser Met Glu His Leu Ser Arg His Trp Leu Phe Ser Pro 
225                 230                 235                 240 


Phe Lys Leu Val Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                245                 250                 255     


Trp Cys Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
            260                 265                 270         


Asp Ala Ser Arg Pro Val Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
        275                 280                 285             


Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Pro Tyr Val Met Leu 
    290                 295                 300                 


Ala Ser Ser Pro Leu Phe Cys Ser Ala Glu Trp Pro Arg Lys Leu Val 
305                 310                 315                 320 


Ala Arg Cys Pro Lys Arg Leu Gln Glu Leu Leu Pro Thr Lys Ala Ala 
                325                 330                 335     


Pro Arg Pro Ser Ala Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ala 
            340                 345                 350         


Gly Pro Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ile Phe Thr Leu 
        355                 360                 365             


Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
    370                 375                 380                 


Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
385                 390                 395                 400 


Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                405                 410                 415     


Asp Gly Leu Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
            420                 425                 430         


Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
        435                 440                 445             


Thr Cys Leu Ser Leu Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
    450                 455                 460                 


Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
465                 470                 475                 480 


Leu Phe Asp Pro Arg Val Asp Ile Val Gln Ala Val Trp Ser Pro Phe 
                485                 490                 495     


Gln Arg Thr Pro Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
            500                 505                 510         


Arg Thr Lys Leu Gln Asp Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
        515                 520                 525             


Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
    530                 535                 540                 


Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
545                 550                 555                 560 


Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Gln Glu Gly 
                565                 570                 575     


Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Val 
            580                 585                 590         


Ser Ser Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
        595                 600                 605             


Val Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
    610                 615                 620                 


Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
625                 630                 635                 640 


Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                645                 650                 655     


Gln Thr Phe Leu Arg Arg Gln Arg Lys Leu Gln Glu Ile Glu Arg Arg 
            660                 665                 670         


Arg Asn Ser Pro Phe His Glu Arg Phe Leu Arg Phe Val Leu Arg Lys 
        675                 680                 685             


Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Arg Ile Ser Leu Arg 
    690                 695                 700                 


Asn Leu Leu Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
705                 710                 715                 720 


Thr Tyr Ala Asn Leu Arg Pro Phe Glu Pro Val Asp Glu Ser Ser Ala 
                725                 730                 735     


Ser Asn Thr Asp Ser Ser Asn His Pro Ser Glu Pro Asp Ser Glu His 
            740                 745                 750         


Val His Ser Glu Phe 
        755         


<210> 10
<211> 5555
<212> DNA
<213> Mus musculus

<400> 10
ggctgtggga gagcagaaga ggagctggaa gagcagccta caacagctgt cgggagggac       60

cagggctagt tcacacttgg aagctgggat gccaggaccg gccctcctgc ctctctcggt      120

ctccatcggc ctcctggtca gctcactcca cactgagacg attctgaagt aagatgctcc      180

tggctcctca cagactctgc tacaagagac agagtgaagt gtccccaggg ctcagagcct      240

ttgactctgc tccttccctt cccacggctg agttggcaca ggagcacctg ggtgagctgc      300

accagactta agaagatgag gcccctgatt ctgttagctg ccctcctctg gctccaggac      360

tctttggccc aggaagatgt atgctcatcc ttggatggga gcccagacag gcagggtgga      420

ggtccacctc tgagtgtgaa cgtcagcagc cgcggaaagc ctaccagcct gtttctgagc      480

tgggtagctg cagagccagg tggatttgac tatgccctct gcctcagggc tatgaacttg      540

tcgggttttc cagaagggca acagctccaa gctcatacca acgagtccag ctttgagttc      600

catggcctgg tgccagggag tcgctaccag ctggaactga ctgtcctaag accctgttgg      660

cagaatgtca caattaccct cactgctcga actgccccta cagtggtccg tggactgcaa      720

ctgcatagca ctgggagccc agccagcctg gaagcctcat ggagcgatgc ctctggggat      780

caagacagct atcaacttct cctctaccac ccggaatccc acactctggc atgtaatgtc      840

tctgtgtccc ctgacaccct gtcttacaat tttggtgacc tcttgccagg tagtcagtat      900

gtcttggagg ttatcacctg ggctggcagt ctccatgcga agactagcat cctccaatgg      960

acagagcctg tccctcctga tcacctaaca ctgcgtgcct tgggtaccag tagcctgcaa     1020

gccttctgga acagctctga aggggccacc tggtttcacc tgatacttac agacctccta     1080

gagggtacca acctgaccaa agtggtcaga caaggcatct caacccacac cttccttcgc     1140

ctgtctccgg gtacacctta ccagctgaag atctgtgctg ctgctgggcc ccaccagatt     1200

tggggaccca atgccactga gtggacctat ccctcttacc catctgacct ggtgctgacc     1260

cccttatgga atgagctctg ggcaagctgg aaggcagggc agggagcccg ggatggctat     1320

gtactgaagt taagtgggcc agtggagaat acaactactc tgggtcctga ggagtgcaac     1380

gctgtcttcc cagggcccct gcctccagga cactacactt tggggctgag ggttctagct     1440

ggaccttatg atgcctgggt agagggcagt atctggctgg ctgaatctgc tgctcgtccc     1500

atggaggtcc ctggtgccag actgtggcta gaaggactgg aagctactaa gcaacctggg     1560

agacgggcgc tgctctattc tgttgatgcc ccaggcctcc tagggaacat ctctgtgtct     1620

tctggtgcca ctcatgtcac cttctgtggc ttggtacccg gagcgcacta cagggtggac     1680

attgcctcat ccatgggaga catcactcag agcctcacag gctacacaag tcccctgcca     1740

ccacagtctc tggagatcat cagccggaac agcccatctg acctgactat cggttgggct     1800

ccagcaccag ggcagatgga aggttataag gtcacctggc atcaggatgg cagccagagg     1860

tcacctggcg accttgttga cttgggccct gacatttcga gcctgactct gaaatctctg     1920

gtacctggtt cctgctacac cgtgtcagca tgggcctggt ctgggaacct cagctctgac     1980

tctcagaaga ttcacagttg cacccgtccc gctcctccca ccaacctgag cctgggcttt     2040

gcccaccagc ctgcaacact gagggcttcc tggtgtcacc caccgggtgg cagggatgcc     2100

tttcagttac ggctttacag gctgaggccc ctgacactgg aaagtgagaa gatcctatcc     2160

caggaggccc agaacttctc ctgggcccag ctgcctgcag gctatgaatt ccaggtacag     2220

ctgtctacct tgtgggggtc ggaggagagc ggcagtgcca acaccacagg ctggacaccc     2280

ccctcagctc ctacattggt aaatgtgacc agtgaagccc ccacccagct ccacgtatcc     2340

tgggtccacg ctgctgggga ccggagcagc taccaagtga ccctatacca ggagagcact     2400

cggacagcca ccagcattgt ggggcccaag gcagacagca caagcttttg gggtttgact     2460

cctggcacta agtacaaggt ggaagccatc tcctgggctg ggccccttta cactgcagca     2520

gccaacgttt ctgcttggac ctacccactc acacccaatg agctgctcgc ctctatgcag     2580

gcaggcagtg ctgtggttaa cctggcctgg cccagtggtc ccttggggca agggacatgc     2640

catgcccaac tctcagatgc tggacacctt tcatgggagc aaccgctgtc gctaggccaa     2700

gacctcctca tgctaaggaa tcttatacca ggacatacgg tttcattgtc tgtgaagtgt     2760

cgggcaggac cactccaggc ctccactcac cccctggtgc tgtctgtaga gcctggccct     2820

gtggaagatg tgttctgtca acctgaggcc acctacctgt ccctgaactg gacgatgcct     2880

actggagatg tggctgtctg tctggtggag gtagagcagc tggtgccagg agggagcgct     2940

cattttgtct tccaggtcaa cacctcggag gatgcacttc tgctgcccaa cttgacgccc     3000

accacttctt accgccttag cctcactgtg ctgggtggga atcgccagtg gagccgggcg     3060

gttaccctgg tgtgcactac ttctgctgag gtttggcacc ccccagagct agctgaggcc     3120

ccccaggtgg agctggggac agggatgggt gtgacagtca cacgtggcat gtttggtaaa     3180

gatgacgggc agatccagtg gtatggcata attgccacca tcaacatgac actggcccag     3240

ccttcccagg aagccatcaa ccacacatgg tatgaccact actatagagg acatgactcc     3300

tacctggctc tcctgttccc aaaccccttc tacccagagc cttgggctgt gccaagatcc     3360

tggacagtac ctgtgggtac agaggactgt gacaacaccc aggagatatg caatgggcat     3420

ctcaagccag gcttccagta taggttcagc attgcagcct ttagtaggct cagctctcca     3480

gagaccatcc tggccttctc cgccttctca gagcctcagg ctagcatctc tctggtggcc     3540

atgcccctga cagttatgat ggggactgtg gtgggctgca tcatcattgt gtgtgcagtg     3600

ctatgcttgt tgtgccggcg gcgcctgaag ggaccaaggt cagagaagaa tggcttttcc     3660

caggagttga tgccttacaa cctgtggcgg acccatcggc ccatccccag ccatagcttc     3720

cggcagagct atgaggccaa gagtgcacgt gcacaccagg ccttcttcca ggaatttgag     3780

gagctgaagg aggtgggcaa ggaccagccc agactagagg ctgagcatcc tgccaacatc     3840

accaagaacc ggtacccaca cgtgctacct tatgaccact ccagggtcag gctgacccag     3900

ctatcaggag agcctcattc tgactacatc aatgccaact tcatcccagg ctatagccac     3960

ccacaggaga tcattgccac ccaggggcct ctcaaaaaga cggtcgagga cttctggcgg     4020

ttggtgtggg agcagcaagt ccacgtgatc atcatgctaa ctgtgggcat ggagaatggg     4080

cgggtactgt gtgagcacta ctggccagtc aactccacgc ctgtcaccca cggtcacatc     4140

accacccacc tcctggcaga ggaatctgag gacgagtgga ccaggaggga attccagctg     4200

cagcacggtg cagagcaaaa acagaggcgc gtgaagcagc tgcagttcac gacctggcca     4260

gaccacagtg tccccgaggc tcccagctct ctgctcgctt ttgtggaact ggtgcaggag     4320

gaggtgaagg caactcaggg caaggggccc atcctggtgc attgcagtgc gggtgtgggc     4380

aggacaggca cctttgtggc tctcttaccg gctgttcgac aactagagga agaacaggtg     4440

gtcgatgtgt tcaacactgt gtacatactc cggctgcacc ggcccctcat gatccagacc     4500

ttgagtcaat acatcttcct gcacagctgc ctgctgaaca agattctgga agggccctct     4560

gacgcctcag actccggccc catccctgtg atgaattttg cacaagcttg tgccaagagg     4620

gcagccaatg ccaatgccgg tttcttgaag gagtacaggc tcctgaagca ggccatcaag     4680

gatgagactg gctctctgct gccctctcct gactataatc agaacagcat cgcctcctgt     4740

catcattctc aggagcagtt ggccctggtg gaggagagcc ctgctgataa catgctggca     4800

gcctcgctct tccctggtgg gccgtctggt cgcgaccatg tggtgctgac tggctcggcc     4860

ggaccaaagg aactctggga aatggtgtgg gaacatggcg cctatgtgct tgtctccctg     4920

ggtctgcctg ataccaagga gaagccacaa gacatctggc caatggagat gcagcctatt     4980

gtcacagaca tggtgacagt gcacagagtg gctgagagca acacagctgg ctggcccagt     5040

accctcatca gagttataca tggggacagt gggacggaaa ggcaggttca atgcctgcag     5100

tttccacact gcgagactgg gagtgagctc ccagctaaca ccctactgac cttccttgat     5160

gctgtgggcc agtgctgctc ccggggcaat agcaagaagc cagggaccct gctcagtcac     5220

tccagcaagg tcacaaacca gctgagcacc ttcttggcta tggaacagct gctacagcaa     5280

gcagggaccg agcgcacagt ggatgtcttc agtgtggccc tgaagcagac acaggcctgt     5340

ggccttaaga ccccaacgct ggagcagtat atctacctct acaactgtct gaacagcgca     5400

ttgaggaaca ggctgccccg agctaggaag tgaccttgcc ctgctaggca tcacgttcca     5460

gcaatccacc caggcctggc ttccccagga gaacagatct attcggcctc acgctgtcaa     5520

agggcagagt ctgggaataa agggtaaatc tcgag                                5555


<210> 11
<211> 1705
<212> PRT
<213> Mus musculus

<400> 11
Met Arg Pro Leu Ile Leu Leu Ala Ala Leu Leu Trp Leu Gln Asp Ser 
1               5                   10                  15      


Leu Ala Gln Glu Asp Val Cys Ser Ser Leu Asp Gly Ser Pro Asp Arg 
            20                  25                  30          


Gln Gly Gly Gly Pro Pro Leu Ser Val Asn Val Ser Ser Arg Gly Lys 
        35                  40                  45              


Pro Thr Ser Leu Phe Leu Ser Trp Val Ala Ala Glu Pro Gly Gly Phe 
    50                  55                  60                  


Asp Tyr Ala Leu Cys Leu Arg Ala Met Asn Leu Ser Gly Phe Pro Glu 
65                  70                  75                  80  


Gly Gln Gln Leu Gln Ala His Thr Asn Glu Ser Ser Phe Glu Phe His 
                85                  90                  95      


Gly Leu Val Pro Gly Ser Arg Tyr Gln Leu Glu Leu Thr Val Leu Arg 
            100                 105                 110         


Pro Cys Trp Gln Asn Val Thr Ile Thr Leu Thr Ala Arg Thr Ala Pro 
        115                 120                 125             


Thr Val Val Arg Gly Leu Gln Leu His Ser Thr Gly Ser Pro Ala Ser 
    130                 135                 140                 


Leu Glu Ala Ser Trp Ser Asp Ala Ser Gly Asp Gln Asp Ser Tyr Gln 
145                 150                 155                 160 


Leu Leu Leu Tyr His Pro Glu Ser His Thr Leu Ala Cys Asn Val Ser 
                165                 170                 175     


Val Ser Pro Asp Thr Leu Ser Tyr Asn Phe Gly Asp Leu Leu Pro Gly 
            180                 185                 190         


Ser Gln Tyr Val Leu Glu Val Ile Thr Trp Ala Gly Ser Leu His Ala 
        195                 200                 205             


Lys Thr Ser Ile Leu Gln Trp Thr Glu Pro Val Pro Pro Asp His Leu 
    210                 215                 220                 


Thr Leu Arg Ala Leu Gly Thr Ser Ser Leu Gln Ala Phe Trp Asn Ser 
225                 230                 235                 240 


Ser Glu Gly Ala Thr Trp Phe His Leu Ile Leu Thr Asp Leu Leu Glu 
                245                 250                 255     


Gly Thr Asn Leu Thr Lys Val Val Arg Gln Gly Ile Ser Thr His Thr 
            260                 265                 270         


Phe Leu Arg Leu Ser Pro Gly Thr Pro Tyr Gln Leu Lys Ile Cys Ala 
        275                 280                 285             


Ala Ala Gly Pro His Gln Ile Trp Gly Pro Asn Ala Thr Glu Trp Thr 
    290                 295                 300                 


Tyr Pro Ser Tyr Pro Ser Asp Leu Val Leu Thr Pro Leu Trp Asn Glu 
305                 310                 315                 320 


Leu Trp Ala Ser Trp Lys Ala Gly Gln Gly Ala Arg Asp Gly Tyr Val 
                325                 330                 335     


Leu Lys Leu Ser Gly Pro Val Glu Asn Thr Thr Thr Leu Gly Pro Glu 
            340                 345                 350         


Glu Cys Asn Ala Val Phe Pro Gly Pro Leu Pro Pro Gly His Tyr Thr 
        355                 360                 365             


Leu Gly Leu Arg Val Leu Ala Gly Pro Tyr Asp Ala Trp Val Glu Gly 
    370                 375                 380                 


Ser Ile Trp Leu Ala Glu Ser Ala Ala Arg Pro Met Glu Val Pro Gly 
385                 390                 395                 400 


Ala Arg Leu Trp Leu Glu Gly Leu Glu Ala Thr Lys Gln Pro Gly Arg 
                405                 410                 415     


Arg Ala Leu Leu Tyr Ser Val Asp Ala Pro Gly Leu Leu Gly Asn Ile 
            420                 425                 430         


Ser Val Ser Ser Gly Ala Thr His Val Thr Phe Cys Gly Leu Val Pro 
        435                 440                 445             


Gly Ala His Tyr Arg Val Asp Ile Ala Ser Ser Met Gly Asp Ile Thr 
    450                 455                 460                 


Gln Ser Leu Thr Gly Tyr Thr Ser Pro Leu Pro Pro Gln Ser Leu Glu 
465                 470                 475                 480 


Ile Ile Ser Arg Asn Ser Pro Ser Asp Leu Thr Ile Gly Trp Ala Pro 
                485                 490                 495     


Ala Pro Gly Gln Met Glu Gly Tyr Lys Val Thr Trp His Gln Asp Gly 
            500                 505                 510         


Ser Gln Arg Ser Pro Gly Asp Leu Val Asp Leu Gly Pro Asp Ile Ser 
        515                 520                 525             


Ser Leu Thr Leu Lys Ser Leu Val Pro Gly Ser Cys Tyr Thr Val Ser 
    530                 535                 540                 


Ala Trp Ala Trp Ser Gly Asn Leu Ser Ser Asp Ser Gln Lys Ile His 
545                 550                 555                 560 


Ser Cys Thr Arg Pro Ala Pro Pro Thr Asn Leu Ser Leu Gly Phe Ala 
                565                 570                 575     


His Gln Pro Ala Thr Leu Arg Ala Ser Trp Cys His Pro Pro Gly Gly 
            580                 585                 590         


Arg Asp Ala Phe Gln Leu Arg Leu Tyr Arg Leu Arg Pro Leu Thr Leu 
        595                 600                 605             


Glu Ser Glu Lys Ile Leu Ser Gln Glu Ala Gln Asn Phe Ser Trp Ala 
    610                 615                 620                 


Gln Leu Pro Ala Gly Tyr Glu Phe Gln Val Gln Leu Ser Thr Leu Trp 
625                 630                 635                 640 


Gly Ser Glu Glu Ser Gly Ser Ala Asn Thr Thr Gly Trp Thr Pro Pro 
                645                 650                 655     


Ser Ala Pro Thr Leu Val Asn Val Thr Ser Glu Ala Pro Thr Gln Leu 
            660                 665                 670         


His Val Ser Trp Val His Ala Ala Gly Asp Arg Ser Ser Tyr Gln Val 
        675                 680                 685             


Thr Leu Tyr Gln Glu Ser Thr Arg Thr Ala Thr Ser Ile Val Gly Pro 
    690                 695                 700                 


Lys Ala Asp Ser Thr Ser Phe Trp Gly Leu Thr Pro Gly Thr Lys Tyr 
705                 710                 715                 720 


Lys Val Glu Ala Ile Ser Trp Ala Gly Pro Leu Tyr Thr Ala Ala Ala 
                725                 730                 735     


Asn Val Ser Ala Trp Thr Tyr Pro Leu Thr Pro Asn Glu Leu Leu Ala 
            740                 745                 750         


Ser Met Gln Ala Gly Ser Ala Val Val Asn Leu Ala Trp Pro Ser Gly 
        755                 760                 765             


Pro Leu Gly Gln Gly Thr Cys His Ala Gln Leu Ser Asp Ala Gly His 
    770                 775                 780                 


Leu Ser Trp Glu Gln Pro Leu Ser Leu Gly Gln Asp Leu Leu Met Leu 
785                 790                 795                 800 


Arg Asn Leu Ile Pro Gly His Thr Val Ser Leu Ser Val Lys Cys Arg 
                805                 810                 815     


Ala Gly Pro Leu Gln Ala Ser Thr His Pro Leu Val Leu Ser Val Glu 
            820                 825                 830         


Pro Gly Pro Val Glu Asp Val Phe Cys Gln Pro Glu Ala Thr Tyr Leu 
        835                 840                 845             


Ser Leu Asn Trp Thr Met Pro Thr Gly Asp Val Ala Val Cys Leu Val 
    850                 855                 860                 


Glu Val Glu Gln Leu Val Pro Gly Gly Ser Ala His Phe Val Phe Gln 
865                 870                 875                 880 


Val Asn Thr Ser Glu Asp Ala Leu Leu Leu Pro Asn Leu Thr Pro Thr 
                885                 890                 895     


Thr Ser Tyr Arg Leu Ser Leu Thr Val Leu Gly Gly Asn Arg Gln Trp 
            900                 905                 910         


Ser Arg Ala Val Thr Leu Val Cys Thr Thr Ser Ala Glu Val Trp His 
        915                 920                 925             


Pro Pro Glu Leu Ala Glu Ala Pro Gln Val Glu Leu Gly Thr Gly Met 
    930                 935                 940                 


Gly Val Thr Val Thr Arg Gly Met Phe Gly Lys Asp Asp Gly Gln Ile 
945                 950                 955                 960 


Gln Trp Tyr Gly Ile Ile Ala Thr Ile Asn Met Thr Leu Ala Gln Pro 
                965                 970                 975     


Ser Gln Glu Ala Ile Asn His Thr Trp Tyr Asp His Tyr Tyr Arg Gly 
            980                 985                 990         


His Asp Ser Tyr Leu Ala Leu Leu  Phe Pro Asn Pro Phe  Tyr Pro Glu 
        995                 1000                 1005             


Pro Trp  Ala Val Pro Arg Ser  Trp Thr Val Pro Val  Gly Thr Glu 
    1010                 1015                 1020             


Asp Cys  Asp Asn Thr Gln Glu  Ile Cys Asn Gly His  Leu Lys Pro 
    1025                 1030                 1035             


Gly Phe  Gln Tyr Arg Phe Ser  Ile Ala Ala Phe Ser  Arg Leu Ser 
    1040                 1045                 1050             


Ser Pro  Glu Thr Ile Leu Ala  Phe Ser Ala Phe Ser  Glu Pro Gln 
    1055                 1060                 1065             


Ala Ser  Ile Ser Leu Val Ala  Met Pro Leu Thr Val  Met Met Gly 
    1070                 1075                 1080             


Thr Val  Val Gly Cys Ile Ile  Ile Val Cys Ala Val  Leu Cys Leu 
    1085                 1090                 1095             


Leu Cys  Arg Arg Arg Leu Lys  Gly Pro Arg Ser Glu  Lys Asn Gly 
    1100                 1105                 1110             


Phe Ser  Gln Glu Leu Met Pro  Tyr Asn Leu Trp Arg  Thr His Arg 
    1115                 1120                 1125             


Pro Ile  Pro Ser His Ser Phe  Arg Gln Ser Tyr Glu  Ala Lys Ser 
    1130                 1135                 1140             


Ala Arg  Ala His Gln Ala Phe  Phe Gln Glu Phe Glu  Glu Leu Lys 
    1145                 1150                 1155             


Glu Val  Gly Lys Asp Gln Pro  Arg Leu Glu Ala Glu  His Pro Ala 
    1160                 1165                 1170             


Asn Ile  Thr Lys Asn Arg Tyr  Pro His Val Leu Pro  Tyr Asp His 
    1175                 1180                 1185             


Ser Arg  Val Arg Leu Thr Gln  Leu Ser Gly Glu Pro  His Ser Asp 
    1190                 1195                 1200             


Tyr Ile  Asn Ala Asn Phe Ile  Pro Gly Tyr Ser His  Pro Gln Glu 
    1205                 1210                 1215             


Ile Ile  Ala Thr Gln Gly Pro  Leu Lys Lys Thr Val  Glu Asp Phe 
    1220                 1225                 1230             


Trp Arg  Leu Val Trp Glu Gln  Gln Val His Val Ile  Ile Met Leu 
    1235                 1240                 1245             


Thr Val  Gly Met Glu Asn Gly  Arg Val Leu Cys Glu  His Tyr Trp 
    1250                 1255                 1260             


Pro Val  Asn Ser Thr Pro Val  Thr His Gly His Ile  Thr Thr His 
    1265                 1270                 1275             


Leu Leu  Ala Glu Glu Ser Glu  Asp Glu Trp Thr Arg  Arg Glu Phe 
    1280                 1285                 1290             


Gln Leu  Gln His Gly Ala Glu  Gln Lys Gln Arg Arg  Val Lys Gln 
    1295                 1300                 1305             


Leu Gln  Phe Thr Thr Trp Pro  Asp His Ser Val Pro  Glu Ala Pro 
    1310                 1315                 1320             


Ser Ser  Leu Leu Ala Phe Val  Glu Leu Val Gln Glu  Glu Val Lys 
    1325                 1330                 1335             


Ala Thr  Gln Gly Lys Gly Pro  Ile Leu Val His Cys  Ser Ala Gly 
    1340                 1345                 1350             


Val Gly  Arg Thr Gly Thr Phe  Val Ala Leu Leu Pro  Ala Val Arg 
    1355                 1360                 1365             


Gln Leu  Glu Glu Glu Gln Val  Val Asp Val Phe Asn  Thr Val Tyr 
    1370                 1375                 1380             


Ile Leu  Arg Leu His Arg Pro  Leu Met Ile Gln Thr  Leu Ser Gln 
    1385                 1390                 1395             


Tyr Ile  Phe Leu His Ser Cys  Leu Leu Asn Lys Ile  Leu Glu Gly 
    1400                 1405                 1410             


Pro Ser  Asp Ala Ser Asp Ser  Gly Pro Ile Pro Val  Met Asn Phe 
    1415                 1420                 1425             


Ala Gln  Ala Cys Ala Lys Arg  Ala Ala Asn Ala Asn  Ala Gly Phe 
    1430                 1435                 1440             


Leu Lys  Glu Tyr Arg Leu Leu  Lys Gln Ala Ile Lys  Asp Glu Thr 
    1445                 1450                 1455             


Gly Ser  Leu Leu Pro Ser Pro  Asp Tyr Asn Gln Asn  Ser Ile Ala 
    1460                 1465                 1470             


Ser Cys  His His Ser Gln Glu  Gln Leu Ala Leu Val  Glu Glu Ser 
    1475                 1480                 1485             


Pro Ala  Asp Asn Met Leu Ala  Ala Ser Leu Phe Pro  Gly Gly Pro 
    1490                 1495                 1500             


Ser Gly  Arg Asp His Val Val  Leu Thr Gly Ser Ala  Gly Pro Lys 
    1505                 1510                 1515             


Glu Leu  Trp Glu Met Val Trp  Glu His Gly Ala Tyr  Val Leu Val 
    1520                 1525                 1530             


Ser Leu  Gly Leu Pro Asp Thr  Lys Glu Lys Pro Gln  Asp Ile Trp 
    1535                 1540                 1545             


Pro Met  Glu Met Gln Pro Ile  Val Thr Asp Met Val  Thr Val His 
    1550                 1555                 1560             


Arg Val  Ala Glu Ser Asn Thr  Ala Gly Trp Pro Ser  Thr Leu Ile 
    1565                 1570                 1575             


Arg Val  Ile His Gly Asp Ser  Gly Thr Glu Arg Gln  Val Gln Cys 
    1580                 1585                 1590             


Leu Gln  Phe Pro His Cys Glu  Thr Gly Ser Glu Leu  Pro Ala Asn 
    1595                 1600                 1605             


Thr Leu  Leu Thr Phe Leu Asp  Ala Val Gly Gln Cys  Cys Ser Arg 
    1610                 1615                 1620             


Gly Asn  Ser Lys Lys Pro Gly  Thr Leu Leu Ser His  Ser Ser Lys 
    1625                 1630                 1635             


Val Thr  Asn Gln Leu Ser Thr  Phe Leu Ala Met Glu  Gln Leu Leu 
    1640                 1645                 1650             


Gln Gln  Ala Gly Thr Glu Arg  Thr Val Asp Val Phe  Ser Val Ala 
    1655                 1660                 1665             


Leu Lys  Gln Thr Gln Ala Cys  Gly Leu Lys Thr Pro  Thr Leu Glu 
    1670                 1675                 1680             


Gln Tyr  Ile Tyr Leu Tyr Asn  Cys Leu Asn Ser Ala  Leu Arg Asn 
    1685                 1690                 1695             


Arg Leu  Pro Arg Ala Arg Lys  
    1700                 1705 


<210> 12
<211> 49
<212> PRT
<213> Homo sapiens

<400> 12
Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu 
1               5                   10                  15      


Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys Asp Glu Leu 
            20                  25                  30          


Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe Tyr Gly Pro 
        35                  40                  45              


Val 
    


<210> 13
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid or amino acid analog

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Any amino acid or amino acid analog

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Any amino acid or amino acid analog

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 13
Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu 
1               5                   10                  15      


Xaa Pro Arg Arg Xaa Val Cys Xaa Leu Asn Pro Asp Cys Asp Glu Leu 
            20                  25                  30          


Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe Tyr Gly Pro 
        35                  40                  45              


Val 
    


<210> 14
<211> 5446
<212> DNA
<213> Rattus norvegicus

<400> 14
agaacagcct acaacagctg ccttccggga gggaccaggc tagttcacac ttggaagttg       60

ggatgccagg agcagccttc tgtcttccga ggccttcctg ggtctcctgg tcagctcatt      120

ccacactgag atgattctaa agaaagatcc tcacacagac tctgctggaa gaaacaaagt      180

gaagtgtccc cagactttat caggatgagg cccctgattc tgttagctgc cctcctctgg      240

ctccagggct ttttggccga ggacgacgca tgctcatcct tggaagggag cccagacagg      300

cagggtggag gtccacttct gagtgtgaac gtcagtagcc atggaaagtc taccagcctg      360

tttctgagct gggtagctgc agagctgggc ggatttgact atgccctcag cctcaggagt      420

gtgaactcct caggttctcc agaagggcaa cagctccagg ctcacacaaa tgagtccggc      480

tttgagttcc atggcctggt gccagggagt cgctaccagc taaaactgac tgtcctaaga      540

ccctgttggc agaatgtcac aattaccctc actgcccgaa ctgccccgac agtggtccgt      600

ggactgcagc tgcatagcgc tgggagccca gccaggctgg aagcctcgtg gagtgatgcc      660

cctggagatc aagacagcta ccaacttctc ctctaccacc tggaatccca aactctggca      720

tgcaatgtct ctgtgtcccc tgacaccctg tcttacagtt ttggcgacct tttgccaggt      780

actcagtatg tcttggaggt tatcacctgg gctggcagtc tccatgcgaa gactagtatc      840

ctccagtgga cagagcctgt ccctcctgat cacctagcac tacgtgcctt gggtaccagt      900

agcctgcaag ccttctggaa cagctctgaa ggggccacct cgtttcacct gatgctcaca      960

gacctcctcg ggggcaccaa cacgactgcg gtgatcagac aaggggtctc gacccacacc     1020

tttcttcacc tatctccggg tacacctcat gagctgaaga tttgtgcttc tgctgggccc     1080

caccagatct ggggacccag tgccaccgag tggacctatc cctcttaccc atctgacctg     1140

gtgctgactc ccttacggaa tgagctctgg gccagctgga aggcagggct gggagcccgg     1200

gacggctatg tactgaagtt aagtgggcca atggagagta cgtctaccct gggcccggaa     1260

gagtgcaatg cagtcttccc agggcccctg cctccgggac actacacttt gcagctgaag     1320

gttctagctg gaccttatga tgcctgggtg gagggcagta cctggctggc tgaatctgct     1380

gcccttccca gggaggtccc tggtgccaga ctgtggctag atggactgga agcttccaag     1440

cagcctggga gacgggcgct actctattct gacgatgccc caggctccct agggaacatc     1500

tctgtgccct ctggtgccac tcacgtcatt ttctgtggcc tggtacctgg agcccactat     1560

agggtggaca ttgcctcatc cacgggggac atctctcaga gcatctcagg ctatacaagt     1620

cccctgccac cgcagtcact ggaggtcatc agcaggagca gcccatctga cctgactatt     1680

gcttggggtc cagcaccagg gcagctggaa ggttataagg ttacctggca tcaggatggc     1740

agccagaggt ctcctggcga ccttgttgac ttgggccctg acactttgag cctgactctg     1800

aaatctctgg tacccggctc ctgctacacc gtgtcagcat gggcctgggc cgggaacctc     1860

gactctgact ctcagaagat tcacagctgc acccgccccg ctcctcccac caacctgagt     1920

ctgggctttg cccaccagcc tgcggcactg aaggcttcct ggtatcaccc accgggtggc     1980

agggatgcct ttcacttacg gctttacagg ctgaggcctc tgacactgga aagtgagaag     2040

gtcctacctc gggaggccca gaacttctcc tgggcccagc tgactgcagg ctgtgagttc     2100

caggtacagc tgtctacctt gtgggggtct gagagaagca gcagtgccaa cgccacaggc     2160

tggacacccc cttcagctcc tacactggta aacgtgacca gcgatgctcc tacccagctc     2220

caagtatcct gggcccacgt tcctgggggc cggagccgct accaagtgac cctataccag     2280

gagagtaccc ggacagccac cagcatcatg gggcccaagg aagatggcac gagctttttg     2340

ggtttgactc ctggcactaa gtacaaggtg gaagtcatct cctgggctgg gcccctctac     2400

actgcagcag ccaacgtttc tgcctggacc tacccactca tacccaatga gctgctcgtg     2460

tcaatgcagg caggcagtgc tgtggttaac ctggcctggc ccagtggtcc cctggggcaa     2520

ggggcatgcc acgcccaact ctcagatgct ggacacctct catgggagca acccctgaaa     2580

ctaggccaag agctcttcat gctaagggat ctcacaccag gacataccat ctcgatgtca     2640

gtgaggtgtc gggcagggcc gctccaggcc tctacgcacc ttgtggtgct gtctgtggag     2700

cctggccctg tggaagatgt gctctgtcat ccagaggcca cctacctggc cctgaactgg     2760

acgatgcctg ctggagacgt ggatgtctgt ctggtggtgg tagagcggct ggtgccggga     2820

gggggcactc attttgtctt ccaggtcaac acctcagggg atgctcttct gttgcccaac     2880

ttgatgccca ccacttctta ccgccttagc ctcaccgttc tgggcaggaa tagtcggtgg     2940

agccgggcgg tttccctggt gtgcagtact tctgctgagg cttggcaccc cccagagcta     3000

gctgagcccc cccaggtgga gctggggaca gggatgggtg tgacagtcat gcgtggcatg     3060

tttggtaaag atgacgggca gatccagtgg tatggcataa ttgccaccat caacatgacg     3120

ctggcccagc cttcccggga agccatcaat tacacatggt atgaccacta ctatagagga     3180

tgtgagtcct tcctggctct cctgttccca aaccccttct acccagagcc ttgggctggg     3240

ccaagatcct ggacagtacc tgtgggtact gaggactgtg acaacaccca agagatatgc     3300

aatgggcgtc tcaagtcagg cttccagtat aggttcagcg ttgtggcctt tagtaggctc     3360

aacactccag agaccatcct cgccttctcg gccttctcag agccccgggc cagcatctct     3420

ctggcgatca ttcccctgac agttatgctg ggggctgtgg tgggcagcat tgtcattgtg     3480

tgtgcagtgc tatgcttgct ccgctggcgg tgcctgaagg gaccaagatc agagaaggat     3540

ggcttttcca aggagctgat gccttacaac ctgtggcgga cccatcggcc tatccccatc     3600

catagcttcc ggcagagcta tgaggccaag agcgcacatg cacaccagac cttcttccag     3660

gaatttgagg agttgaagga ggtaggcaag gaccagcccc gactagaggc tgagcatccg     3720

gacaacatca tcaagaaccg gtacccacac gtgctgccct atgaccactc cagggtcagg     3780

ctgacccagc taccaggaga gcctcattct gactacatca atgccaactt catcccaggc     3840

tatagccaca cacaggagat cattgccacc caggggcctc tcaaaaagac gctagaggac     3900

ttctggcggt tggtatggga gcagcaagtc cacgtgatca tcatgctgac tgtgggcatg     3960

gagaacgggc gggtactgtg tgagcactac tggccagcca actccacgcc tgttactcac     4020

ggtcacatca ccatccacct cctggcagag gagcctgagg atgagtggac caggagggaa     4080

ttccagctgc agcacggtac cgagcaaaaa cagaggcgag tgaagcagct gcagttcact     4140

acctggccag accacagtgt cccggaggct cccagctctc tgctcgcttt tgtagaactg     4200

gtacaggagc aggtgcaggc cactcagggc aagggaccca tcctggtgca ttgcagtgct     4260

ggcgtgggga ggacaggcac ctttgtggct ctcttgcggc tactgcgaca actagaggaa     4320

gagaaggtgg ccgatgtgtt caacactgtg tacatactcc ggttgcaccg gcccctcatg     4380

atccagaccc tgagtcaata catcttcctg cacagttgcc tgctgaacaa gattctggaa     4440

gggccccctg acagctccga ctccggcccc atctctgtga tggattttgc acaggcttgt     4500

gccaagaggg cagccaacgc caatgctggt ttcttgaagg agtacaagct cctgaagcag     4560

gccatcaagg atgggactgg ctctctgctg ccccctcctg actacaatca gaacagcatt     4620

gtctcccgtc gtcattctca ggagcagttc gccctggtgg aggagtgccc tgaggatagc     4680

atgctggaag cctcactctt ccctggtggt ccgtctggtt gtgatcatgt ggtgctgact     4740

ggctcagccg gaccaaagga actctgggaa atggtgtggg agcatgatgc ccatgtgctc     4800

gtctccctgg gcctgcctga taccaaggag aagccaccag acatctggcc agtggagatg     4860

cagcctattg tcacagacat ggtgacagtg cacagagtgt ctgagagcaa cacaacaact     4920

ggctggccca gcaccctctt cagagtcata cacggggaga gtggaaagga aaggcaggtt     4980

caatgcctgc aatttccatg ctctgagtct gggtgtgagc tcccagctaa caccctactg     5040

accttccttg atgctgtggg ccagtgctgc ttccggggca agagcaagaa gccagggacc     5100

ctgctcagcc actccagcaa aaacacaaac cagctgggca ccttcttggc tatggaacag     5160

ctgttacagc aagcagggac agagcgcaca gtggacgtct tcaatgtggc cctgaagcag     5220

tcacaggcct gcggccttat gaccccaaca ctggagcagt atatctacct ctacaactgt     5280

ctgaacagcg cactgctgaa cgggctgccc agagctggga agtggcctgc gccctgctag     5340

gcgtcatgtt ccagcaaatc cacccaggcc tgacttccct aggagagtgg atccaccggg     5400

cctcacactg tccaagggca gagtccagga ataaagagac atggtc                    5446


<210> 15
<211> 1711
<212> PRT
<213> Rattus norvegicus

<400> 15
Met Arg Pro Leu Ile Leu Leu Ala Ala Leu Leu Trp Leu Gln Gly Phe 
1               5                   10                  15      


Leu Ala Glu Asp Asp Ala Cys Ser Ser Leu Glu Gly Ser Pro Asp Arg 
            20                  25                  30          


Gln Gly Gly Gly Pro Leu Leu Ser Val Asn Val Ser Ser His Gly Lys 
        35                  40                  45              


Ser Thr Ser Leu Phe Leu Ser Trp Val Ala Ala Glu Leu Gly Gly Phe 
    50                  55                  60                  


Asp Tyr Ala Leu Ser Leu Arg Ser Val Asn Ser Ser Gly Ser Pro Glu 
65                  70                  75                  80  


Gly Gln Gln Leu Gln Ala His Thr Asn Glu Ser Gly Phe Glu Phe His 
                85                  90                  95      


Gly Leu Val Pro Gly Ser Arg Tyr Gln Leu Lys Leu Thr Val Leu Arg 
            100                 105                 110         


Pro Cys Trp Gln Asn Val Thr Ile Thr Leu Thr Ala Arg Thr Ala Pro 
        115                 120                 125             


Thr Val Val Arg Gly Leu Gln Leu His Ser Ala Gly Ser Pro Ala Arg 
    130                 135                 140                 


Leu Glu Ala Ser Trp Ser Asp Ala Pro Gly Asp Gln Asp Ser Tyr Gln 
145                 150                 155                 160 


Leu Leu Leu Tyr His Leu Glu Ser Gln Thr Leu Ala Cys Asn Val Ser 
                165                 170                 175     


Val Ser Pro Asp Thr Leu Ser Tyr Ser Phe Gly Asp Leu Leu Pro Gly 
            180                 185                 190         


Thr Gln Tyr Val Leu Glu Val Ile Thr Trp Ala Gly Ser Leu His Ala 
        195                 200                 205             


Lys Thr Ser Ile Leu Gln Trp Thr Glu Pro Val Pro Pro Asp His Leu 
    210                 215                 220                 


Ala Leu Arg Ala Leu Gly Thr Ser Ser Leu Gln Ala Phe Trp Asn Ser 
225                 230                 235                 240 


Ser Glu Gly Ala Thr Ser Phe His Leu Met Leu Thr Asp Leu Leu Gly 
                245                 250                 255     


Gly Thr Asn Thr Thr Ala Val Ile Arg Gln Gly Val Ser Thr His Thr 
            260                 265                 270         


Phe Leu His Leu Ser Pro Gly Thr Pro His Glu Leu Lys Ile Cys Ala 
        275                 280                 285             


Ser Ala Gly Pro His Gln Ile Trp Gly Pro Ser Ala Thr Glu Trp Thr 
    290                 295                 300                 


Tyr Pro Ser Tyr Pro Ser Asp Leu Val Leu Thr Pro Leu Arg Asn Glu 
305                 310                 315                 320 


Leu Trp Ala Ser Trp Lys Ala Gly Leu Gly Ala Arg Asp Gly Tyr Val 
                325                 330                 335     


Leu Lys Leu Ser Gly Pro Met Glu Ser Thr Ser Thr Leu Gly Pro Glu 
            340                 345                 350         


Glu Cys Asn Ala Val Phe Pro Gly Pro Leu Pro Pro Gly His Tyr Thr 
        355                 360                 365             


Leu Gln Leu Lys Val Leu Ala Gly Pro Tyr Asp Ala Trp Val Glu Gly 
    370                 375                 380                 


Ser Thr Trp Leu Ala Glu Ser Ala Ala Leu Pro Arg Glu Val Pro Gly 
385                 390                 395                 400 


Ala Arg Leu Trp Leu Asp Gly Leu Glu Ala Ser Lys Gln Pro Gly Arg 
                405                 410                 415     


Arg Ala Leu Leu Tyr Ser Asp Asp Ala Pro Gly Ser Leu Gly Asn Ile 
            420                 425                 430         


Ser Val Pro Ser Gly Ala Thr His Val Ile Phe Cys Gly Leu Val Pro 
        435                 440                 445             


Gly Ala His Tyr Arg Val Asp Ile Ala Ser Ser Thr Gly Asp Ile Ser 
    450                 455                 460                 


Gln Ser Ile Ser Gly Tyr Thr Ser Pro Leu Pro Pro Gln Ser Leu Glu 
465                 470                 475                 480 


Val Ile Ser Arg Ser Ser Pro Ser Asp Leu Thr Ile Ala Trp Gly Pro 
                485                 490                 495     


Ala Pro Gly Gln Leu Glu Gly Tyr Lys Val Thr Trp His Gln Asp Gly 
            500                 505                 510         


Ser Gln Arg Ser Pro Gly Asp Leu Val Asp Leu Gly Pro Asp Thr Leu 
        515                 520                 525             


Ser Leu Thr Leu Lys Ser Leu Val Pro Gly Ser Cys Tyr Thr Val Ser 
    530                 535                 540                 


Ala Trp Ala Trp Ala Gly Asn Leu Asp Ser Asp Ser Gln Lys Ile His 
545                 550                 555                 560 


Ser Cys Thr Arg Pro Ala Pro Pro Thr Asn Leu Ser Leu Gly Phe Ala 
                565                 570                 575     


His Gln Pro Ala Ala Leu Lys Ala Ser Trp Tyr His Pro Pro Gly Gly 
            580                 585                 590         


Arg Asp Ala Phe His Leu Arg Leu Tyr Arg Leu Arg Pro Leu Thr Leu 
        595                 600                 605             


Glu Ser Glu Lys Val Leu Pro Arg Glu Ala Gln Asn Phe Ser Trp Ala 
    610                 615                 620                 


Gln Leu Thr Ala Gly Cys Glu Phe Gln Val Gln Leu Ser Thr Leu Trp 
625                 630                 635                 640 


Gly Ser Glu Arg Ser Ser Ser Ala Asn Ala Thr Gly Trp Thr Pro Pro 
                645                 650                 655     


Ser Ala Pro Thr Leu Val Asn Val Thr Ser Asp Ala Pro Thr Gln Leu 
            660                 665                 670         


Gln Val Ser Trp Ala His Val Pro Gly Gly Arg Ser Arg Tyr Gln Val 
        675                 680                 685             


Thr Leu Tyr Gln Glu Ser Thr Arg Thr Ala Thr Ser Ile Met Gly Pro 
    690                 695                 700                 


Lys Glu Asp Gly Thr Ser Phe Leu Gly Leu Thr Pro Gly Thr Lys Tyr 
705                 710                 715                 720 


Lys Val Glu Val Ile Ser Trp Ala Gly Pro Leu Tyr Thr Ala Ala Ala 
                725                 730                 735     


Asn Val Ser Ala Trp Thr Tyr Pro Leu Ile Pro Asn Glu Leu Leu Val 
            740                 745                 750         


Ser Met Gln Ala Gly Ser Ala Val Val Asn Leu Ala Trp Pro Ser Gly 
        755                 760                 765             


Pro Leu Gly Gln Gly Ala Cys His Ala Gln Leu Ser Asp Ala Gly His 
    770                 775                 780                 


Leu Ser Trp Glu Gln Pro Leu Lys Leu Gly Gln Glu Leu Phe Met Leu 
785                 790                 795                 800 


Arg Asp Leu Thr Pro Gly His Thr Ile Ser Met Ser Val Arg Cys Arg 
                805                 810                 815     


Ala Gly Pro Leu Gln Ala Ser Thr His Leu Val Val Leu Ser Val Glu 
            820                 825                 830         


Pro Gly Pro Val Glu Asp Val Leu Cys His Pro Glu Ala Thr Tyr Leu 
        835                 840                 845             


Ala Leu Asn Trp Thr Met Pro Ala Gly Asp Val Asp Val Cys Leu Val 
    850                 855                 860                 


Val Val Glu Arg Leu Val Pro Gly Gly Gly Thr His Phe Val Phe Gln 
865                 870                 875                 880 


Val Asn Thr Ser Gly Asp Ala Leu Leu Leu Pro Asn Leu Met Pro Thr 
                885                 890                 895     


Thr Ser Tyr Arg Leu Ser Leu Thr Val Leu Gly Arg Asn Ser Arg Trp 
            900                 905                 910         


Ser Arg Ala Val Ser Leu Val Cys Ser Thr Ser Ala Glu Ala Trp His 
        915                 920                 925             


Pro Pro Glu Leu Ala Glu Pro Pro Gln Val Glu Leu Gly Thr Gly Met 
    930                 935                 940                 


Gly Val Thr Val Met Arg Gly Met Phe Gly Lys Asp Asp Gly Gln Ile 
945                 950                 955                 960 


Gln Trp Tyr Gly Ile Ile Ala Thr Ile Asn Met Thr Leu Ala Gln Pro 
                965                 970                 975     


Ser Arg Glu Ala Ile Asn Tyr Thr Trp Tyr Asp His Tyr Tyr Arg Gly 
            980                 985                 990         


Cys Glu Ser Phe Leu Ala Leu Leu  Phe Pro Asn Pro Phe  Tyr Pro Glu 
        995                 1000                 1005             


Pro Trp  Ala Gly Pro Arg Ser  Trp Thr Val Pro Val  Gly Thr Glu 
    1010                 1015                 1020             


Asp Cys  Asp Asn Thr Gln Glu  Ile Cys Asn Gly Arg  Leu Lys Ser 
    1025                 1030                 1035             


Gly Phe  Gln Tyr Arg Phe Ser  Val Val Ala Phe Ser  Arg Leu Asn 
    1040                 1045                 1050             


Thr Pro  Glu Thr Ile Leu Ala  Phe Ser Ala Phe Ser  Glu Pro Arg 
    1055                 1060                 1065             


Ala Ser  Ile Ser Leu Ala Ile  Ile Pro Leu Thr Val  Met Leu Gly 
    1070                 1075                 1080             


Ala Val  Val Gly Ser Ile Val  Ile Val Cys Ala Val  Leu Cys Leu 
    1085                 1090                 1095             


Leu Arg  Trp Arg Cys Leu Lys  Gly Pro Arg Ser Glu  Lys Asp Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Leu Met Pro  Tyr Asn Leu Trp Arg  Thr His Arg 
    1115                 1120                 1125             


Pro Ile  Pro Ile His Ser Phe  Arg Gln Ser Tyr Glu  Ala Lys Ser 
    1130                 1135                 1140             


Ala His  Ala His Gln Thr Phe  Phe Gln Glu Phe Glu  Glu Leu Lys 
    1145                 1150                 1155             


Glu Val  Gly Lys Asp Gln Pro  Arg Leu Glu Ala Glu  His Pro Asp 
    1160                 1165                 1170             


Asn Ile  Ile Lys Asn Arg Tyr  Pro His Val Leu Pro  Tyr Asp His 
    1175                 1180                 1185             


Ser Arg  Val Arg Leu Thr Gln  Leu Pro Gly Glu Pro  His Ser Asp 
    1190                 1195                 1200             


Tyr Ile  Asn Ala Asn Phe Ile  Pro Gly Tyr Ser His  Thr Gln Glu 
    1205                 1210                 1215             


Ile Ile  Ala Thr Gln Gly Pro  Leu Lys Lys Thr Leu  Glu Asp Phe 
    1220                 1225                 1230             


Trp Arg  Leu Val Trp Glu Gln  Gln Val His Val Ile  Ile Met Leu 
    1235                 1240                 1245             


Thr Val  Gly Met Glu Asn Gly  Arg Val Leu Cys Glu  His Tyr Trp 
    1250                 1255                 1260             


Pro Ala  Asn Ser Thr Pro Val  Thr His Gly His Ile  Thr Ile His 
    1265                 1270                 1275             


Leu Leu  Ala Glu Glu Pro Glu  Asp Glu Trp Thr Arg  Arg Glu Phe 
    1280                 1285                 1290             


Gln Leu  Gln His Gly Thr Glu  Gln Lys Gln Arg Arg  Val Lys Gln 
    1295                 1300                 1305             


Leu Gln  Phe Thr Thr Trp Pro  Asp His Ser Val Pro  Glu Ala Pro 
    1310                 1315                 1320             


Ser Ser  Leu Leu Ala Phe Val  Glu Leu Val Gln Glu  Gln Val Gln 
    1325                 1330                 1335             


Ala Thr  Gln Gly Lys Gly Pro  Ile Leu Val His Cys  Ser Ala Gly 
    1340                 1345                 1350             


Val Gly  Arg Thr Gly Thr Phe  Val Ala Leu Leu Arg  Leu Leu Arg 
    1355                 1360                 1365             


Gln Leu  Glu Glu Glu Lys Val  Ala Asp Val Phe Asn  Thr Val Tyr 
    1370                 1375                 1380             


Ile Leu  Arg Leu His Arg Pro  Leu Met Ile Gln Thr  Leu Ser Gln 
    1385                 1390                 1395             


Tyr Ile  Phe Leu His Ser Cys  Leu Leu Asn Lys Ile  Leu Glu Gly 
    1400                 1405                 1410             


Pro Pro  Asp Ser Ser Asp Ser  Gly Pro Ile Ser Val  Met Asp Phe 
    1415                 1420                 1425             


Ala Gln  Ala Cys Ala Lys Arg  Ala Ala Asn Ala Asn  Ala Gly Phe 
    1430                 1435                 1440             


Leu Lys  Glu Tyr Lys Leu Leu  Lys Gln Ala Ile Lys  Asp Gly Thr 
    1445                 1450                 1455             


Gly Ser  Leu Leu Pro Pro Pro  Asp Tyr Asn Gln Asn  Ser Ile Val 
    1460                 1465                 1470             


Ser Arg  Arg His Ser Gln Glu  Gln Phe Ala Leu Val  Glu Glu Cys 
    1475                 1480                 1485             


Pro Glu  Asp Ser Met Leu Glu  Ala Ser Leu Phe Pro  Gly Gly Pro 
    1490                 1495                 1500             


Ser Gly  Cys Asp His Val Val  Leu Thr Gly Ser Ala  Gly Pro Lys 
    1505                 1510                 1515             


Glu Leu  Trp Glu Met Val Trp  Glu His Asp Ala His  Val Leu Val 
    1520                 1525                 1530             


Ser Leu  Gly Leu Pro Asp Thr  Lys Glu Lys Pro Pro  Asp Ile Trp 
    1535                 1540                 1545             


Pro Val  Glu Met Gln Pro Ile  Val Thr Asp Met Val  Thr Val His 
    1550                 1555                 1560             


Arg Val  Ser Glu Ser Asn Thr  Thr Thr Gly Trp Pro  Ser Thr Leu 
    1565                 1570                 1575             


Phe Arg  Val Ile His Gly Glu  Ser Gly Lys Glu Arg  Gln Val Gln 
    1580                 1585                 1590             


Cys Leu  Gln Phe Pro Cys Ser  Glu Ser Gly Cys Glu  Leu Pro Ala 
    1595                 1600                 1605             


Asn Thr  Leu Leu Thr Phe Leu  Asp Ala Val Gly Gln  Cys Cys Phe 
    1610                 1615                 1620             


Arg Gly  Lys Ser Lys Lys Pro  Gly Thr Leu Leu Ser  His Ser Ser 
    1625                 1630                 1635             


Lys Asn  Thr Asn Gln Leu Gly  Thr Phe Leu Ala Met  Glu Gln Leu 
    1640                 1645                 1650             


Leu Gln  Gln Ala Gly Thr Glu  Arg Thr Val Asp Val  Phe Asn Val 
    1655                 1660                 1665             


Ala Leu  Lys Gln Ser Gln Ala  Cys Gly Leu Met Thr  Pro Thr Leu 
    1670                 1675                 1680             


Glu Gln  Tyr Ile Tyr Leu Tyr  Asn Cys Leu Asn Ser  Ala Leu Leu 
    1685                 1690                 1695             


Asn Gly  Leu Pro Arg Ala Gly  Lys Trp Pro Ala Pro  Cys 
    1700                 1705                 1710     


<210> 16
<211> 3247
<212> DNA
<213> Homo sapiens

<400> 16
gggcgggcct cggggctaag agcgcgacgc ctagagcggc agacggcgca gtgggccgag       60

aaggaggcgc agcagccgcc ctggcccgtc atggagatgg aaaaggagtt cgagcagatc      120

gacaagtccg ggagctgggc ggccatttac caggatatcc gacatgaagc cagtgacttc      180

ccatgtagag tggccaagct tcctaagaac aaaaaccgaa ataggtacag agacgtcagt      240

ccctttgacc atagtcggat taaactacat caagaagata atgactatat caacgctagt      300

ttgataaaaa tggaagaagc ccaaaggagt tacattctta cccagggccc tttgcctaac      360

acatgcggtc acttttggga gatggtgtgg gagcagaaaa gcaggggtgt cgtcatgctc      420

aacagagtga tggagaaagg ttcgttaaaa tgcgcacaat actggccaca aaaagaagaa      480

aaagagatga tctttgaaga cacaaatttg aaattaacat tgatctctga agatatcaag      540

tcatattata cagtgcgaca gctagaattg gaaaacctta caacccaaga aactcgagag      600

atcttacatt tccactatac cacatggcct gactttggag tccctgaatc accagcctca      660

ttcttgaact ttcttttcaa agtccgagag tcagggtcac tcagcccgga gcacgggccc      720

gttgtggtgc actgcagtgc aggcatcggc aggtctggaa ccttctgtct ggctgatacc      780

tgcctcctgc tgatggacaa gaggaaagac ccttcttccg ttgatatcaa gaaagtgctg      840

ttagaaatga ggaagtttcg gatggggttg atccagacag ccgaccagct gcgcttctcc      900

tacctggctg tgatcgaagg tgccaaattc atcatggggg actcttccgt gcaggatcag      960

tggaaggagc tttcccacga ggacctggag cccccacccg agcatatccc cccacctccc     1020

cggccaccca aacgaatcct ggagccacac aatgggaaat gcagggagtt cttcccaaat     1080

caccagtggg tgaaggaaga gacccaggag gataaagact gccccatcaa ggaagaaaaa     1140

ggaagcccct taaatgccgc accctacggc atcgaaagca tgagtcaaga cactgaagtt     1200

agaagtcggg tcgtgggggg aagtcttcga ggtgcccagg ctgcctcccc agccaaaggg     1260

gagccgtcac tgcccgagaa ggacgaggac catgcactga gttactggaa gcccttcctg     1320

gtcaacatgt gcgtggctac ggtcctcacg gccggcgctt acctctgcta caggttcctg     1380

ttcaacagca acacatagcc tgaccctcct ccactccacc tccacccact gtccgcctct     1440

gcccgcagag cccacgcccg actagcaggc atgccgcggt aggtaagggc cgccggaccg     1500

cgtagagagc cgggccccgg acggacgttg gttctgcact aaaacccatc ttccccggat     1560

gtgtgtctca cccctcatcc ttttactttt tgccccttcc actttgagta ccaaatccac     1620

aagccatttt ttgaggagag tgaaagagag taccatgctg gcggcgcaga gggaaggggc     1680

ctacacccgt cttggggctc gccccaccca gggctccctc ctggagcatc ccaggcggcg     1740

cacgccaaca gcccccccct tgaatctgca gggagcaact ctccactcca tatttattta     1800

aacaattttt tccccaaagg catccatagt gcactagcat tttcttgaac caataatgta     1860

ttaaaatttt ttgatgtcag ccttgcatca agggctttat caaaaagtac aataataaat     1920

cctcaggtag tactgggaat ggaaggcttt gccatgggcc tgctgcgtca gaccagtact     1980

gggaaggagg acggttgtaa gcagttgtta tttagtgata ttgtgggtaa cgtgagaaga     2040

tagaacaatg ctataatata taatgaacac gtgggtattt aataagaaac atgatgtgag     2100

attactttgt cccgcttatt ctcctccctg ttatctgcta gatctagttc tcaatcactg     2160

ctcccccgtg tgtattagaa tgcatgtaag gtcttcttgt gtcctgatga aaaatatgtg     2220

cttgaaatga gaaactttga tctctgctta ctaatgtgcc ccatgtccaa gtccaacctg     2280

cctgtgcatg acctgatcat tacatggctg tggttcctaa gcctgttgct gaagtcattg     2340

tcgctcagca atagggtgca gttttccagg aataggcatt tgctaattcc tggcatgaca     2400

ctctagtgac ttcctggtga ggcccagcct gtcctggtac agcagggtct tgctgtaact     2460

cagacattcc aagggtatgg gaagccatat tcacacctca cgctctggac atgatttagg     2520

gaagcaggga caccccccgc cccccacctt tgggatcagc ctccgccatt ccaagtcaac     2580

actcttcttg agcagaccgt gatttggaag agaggcacct gctggaaacc acacttcttg     2640

aaacagcctg ggtgacggtc ctttaggcag cctgccgccg tctctgtccc ggttcacctt     2700

gccgagagag gcgcgtctgc cccaccctca aaccctgtgg ggcctgatgg tgctcacgac     2760

tcttcctgca aagggaactg aagacctcca cattaagtgg ctttttaaca tgaaaaacac     2820

ggcagctgta gctcccgagc tactctcttg ccagcatttt cacattttgc ctttctcgtg     2880

gtagaagcca gtacagagaa attctgtggt gggaacattc gaggtgtcac cctgcagagc     2940

tatggtgagg tgtggataag gcttaggtgc caggctgtaa gcattctgag ctggcttgtt     3000

gtttttaagt cctgtatatg tatgtagtag tttgggtgtg tatatatagt agcatttcaa     3060

aatggacgta ctggtttaac ctcctatcct tggagagcag ctggctctcc accttgttac     3120

acattatgtt agagaggtag cgagctgctc tgctatatgc cttaagccaa tatttactca     3180

tcaggtcatt attttttaca atggccatgg aataaaccat ttttacaaaa ataaaaacaa     3240

aaaaagc                                                               3247


<210> 17
<211> 435
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
1               5                   10                  15      


Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Cys 
            20                  25                  30          


Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
        35                  40                  45              


Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
    50                  55                  60                  


Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
65                  70                  75                  80  


Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His Phe Trp 
                85                  90                  95      


Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
            100                 105                 110         


Val Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro Gln Lys 
        115                 120                 125             


Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
    130                 135                 140                 


Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
145                 150                 155                 160 


Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                165                 170                 175     


Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
            180                 185                 190         


Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
        195                 200                 205             


Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr 
    210                 215                 220                 


Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
225                 230                 235                 240 


Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
            260                 265                 270         


Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
        275                 280                 285             


Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
    290                 295                 300                 


His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
305                 310                 315                 320 


Asn Gly Lys Cys Arg Glu Phe Phe Pro Asn His Gln Trp Val Lys Glu 
                325                 330                 335     


Glu Thr Gln Glu Asp Lys Asp Cys Pro Ile Lys Glu Glu Lys Gly Ser 
            340                 345                 350         


Pro Leu Asn Ala Ala Pro Tyr Gly Ile Glu Ser Met Ser Gln Asp Thr 
        355                 360                 365             


Glu Val Arg Ser Arg Val Val Gly Gly Ser Leu Arg Gly Ala Gln Ala 
    370                 375                 380                 


Ala Ser Pro Ala Lys Gly Glu Pro Ser Leu Pro Glu Lys Asp Glu Asp 
385                 390                 395                 400 


His Ala Leu Ser Tyr Trp Lys Pro Phe Leu Val Asn Met Cys Val Ala 
                405                 410                 415     


Thr Val Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn 
            420                 425                 430         


Ser Asn Thr 
        435 


<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ala Gly Leu Tyr Ser Thr Val Leu Met Gly Arg Pro Ser 
1               5                   10              


<210> 19
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Leu Val Ser Thr Val Leu Met Gly Asn 
1               5                   10  


