                         SEQUENCE LISTING

<110>  UNKNOWN
 
<120>  METHODS FOR PROMOTING WOUND HEALING AND HAIR GROWTH

<130>  JLY-001PC

<150>  US 61/787,870
<151>  2013-03-15

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  3810
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens glial cell derived neurotrophic factor (GDNF)

<400>  1
ccgcctccag cgcgcccttg ctgccccgcg cgaccccagg attgcgaact cttgcccctg       60

acctgttggg cggggctccg cgctccagcc atcagcccgg atgggtctcc tggctgggac      120

ttggggcacc tggagttaat gtccaaccta gggtctgcgg agacccgatc cgaggtgccg      180

ccgccggacg ggactttaag atgaagttat gggatgtcgt ggctgtctgc ctggtgctgc      240

tccacaccgc gtccgccttc ccgctgcccg ccggtaagag gcctcccgag gcgcccgccg      300

aagaccgctc cctcggccgc cgccgcgcgc ccttcgcgct gagcagtgac tcaaatatgc      360

cagaggatta tcctgatcag ttcgatgatg tcatggattt tattcaagcc accattaaaa      420

gactgaaaag gtcaccagat aaacaaatgg cagtgcttcc tagaagagag cggaatcggc      480

aggctgcagc tgccaaccca gagaattcca gaggaaaagg tcggagaggc cagaggggca      540

aaaaccgggg ttgtgtctta actgcaatac atttaaatgt cactgacttg ggtctgggct      600

atgaaaccaa ggaggaactg atttttaggt actgcagcgg ctcttgcgat gcagctgaga      660

caacgtacga caaaatattg aaaaacttat ccagaaatag aaggctggtg agtgacaaag      720

tagggcaggc atgttgcaga cccatcgcct ttgatgatga cctgtcgttt ttagatgata      780

acctggttta ccatattcta agaaagcatt ccgctaaaag gtgtggatgt atctgactcc      840

ggctccagag actgctgtgt attgcattcc tgctacagtg caaagaaagg gaccaaggtt      900

cccaggaaat gtttgcccag aatggaagat gaggaccaag gaggcggagg aggaggaaga      960

agaagaggag gaggaggagg aggaggagga ggaggaggaa ggcagccatc atgggagcct     1020

ggtagaggga gatccagcta cagacaactg gacaggagag agagaaaaca gccctctgga     1080

ttctccagga tggcagccga tgtcactaga agctcagggc tgatgttcct ggttggctat     1140

tgccaccatt tcagctgata cagtccacca tcactgatta ccggcgcggt tgcggtggat     1200

gcacttgaac caaaccagtg tatctcctgt gatttgtttt catgtgtccg aagacaccag     1260

ggaaacagag atcctggtgt tgttccttgt tattacgttt tactgctgaa agtaagaggt     1320

ttatttttct gtcactcagt ggagacatac cctggaaagg agaggggaaa aaaaaagcaa     1380

agatacaaga gataatcacc tttgcatttg aaagttgagg cccgaggttt actacaacca     1440

gcatttttgc caacggttgg tgattgattt ccatcacggt gtgtggggtg ggaagaagtt     1500

ggctaggaac caaaaaggct gtgctcatga ttaaacacaa acctgaaggt atttccttta     1560

tgtccttgga aacaggaaac gagttgtggt tttcgccagc attcttgtag gagagaatcg     1620

gggaaggccc cgaactgccc ccgggcaggg agagcccctc aggcctgttg gtttacagag     1680

agacagatgt tacataacca gctccgttga tgcgtggtca ccagtgacca gagaagctac     1740

tcgatgcaat gcatctgttt cagatacaga aatatagaga agatatttat tgaaatttaa     1800

gttattgtta tttattaccg ttcactaatg aatttctctt ttttccctta tttattaaag     1860

tttcttttca aaggtgccaa agtatatgtg ctcgcaaaat gcaaagaaag gtgacaaaag     1920

gaaatttgaa ttgggaacaa gggtccatgc ttttcaaagt attaaaaagt tttttgccag     1980

gcaaaaatca cttactttac ctttttaaga aaatttgtca ttaattttcc ccagatttca     2040

gcatttttcc caatttttat ttgtggagca tctcaggcaa gccccctttc ctggagcagc     2100

gtgcagagac cactggcact tgactttatt tcttccttgc tccattgctg aacagaaatg     2160

tcgtgggctc cacttcctgt tgtctttaag ctcttagtcc cctccacgta tacctatctg     2220

tactatgcat aaccatatgt agaaaaggtt cagttccttt tagtaggtag tcctggattt     2280

aatgctgacc taaaagtaat gtcgacaatg ctgtcaggta gctgccgttc taccgactcc     2340

ctccatccct gcccacccac tgccctcccg agaatatgct ggctgcccag tgcagcccgg     2400

gagacacagg ggccttccag aggtagggtc taccaggtcc tgtacaaccc ctgggctgtc     2460

accgggggtc aacagctgct gctcctatat acccaaacac ctgacagctc cctggggagc     2520

agatggctga gaagggtgct gaggaagcca tattgggacc agccacagcc acacacatgg     2580

agcctcatac ttaggagcgt gctgccttta aatgaaggtg gtcggggcca gtgcagcggc     2640

tcacacccat aatcccaaca ctttggaaag ccaaggtggg aggatctctt gaacccagga     2700

gtttgagacc agcttgggca acatagggag accctgtctc tacagaaact ttaaaaatta     2760

ggcaggcatg atggtgcaca cctgtggtcc cagctactca agaggctgaa ggaggatcac     2820

ttgagtccag aaggtcgagg ctgcagtgag ctgtgatcat gccactgcac tccagcctaa     2880

gtgacagtgc ggtaccctgt ctcaaaaaaa aaaaaaaaaa aaaaaagagg ttggagcagg     2940

aggaagcata ggggcgggaa cagccacctc ctccatgccc tagattgtga atttatcggg     3000

cagccaacac atgtatgaca cactaggccc tgtattacag cttgttacgc atttcataaa     3060

agggattttc attaaggaga taatctatta ctacctacct tagtggctac tagtataaaa     3120

ctatgacaga tttagcaatt aaatgaaata ctggcctcca tcaaataatc atagtaacaa     3180

gaagcagcag ttaccagaca tctgatcccc ttcccccaaa atacccaaat tcttcatggt     3240

tctgcccttc tctgtccttt ctgctcccct tgctcgcctg ggaaatggag gaaaggcctt     3300

ccctctcaca ctgtcttggg atcttgctga gaattcagac tgctcgaaac agtgacaaac     3360

cccagccatc cagtcattcg tggagcacaa tttggatgtg gccccagggg catctgtccc     3420

attcagagaa ccttggcagt gcgatggcca ctgttcccag gcttcaacct cagtgacccc     3480

ccccaacaac tccccatgga gagtccctgc ccaaaaaagc tgtaggatcc aaggggtgtc     3540

aatagctcgt tcccggcatc acctacacac cacaagcagg ttttaatgga agcaagttgc     3600

tccaccaaat ccacaaaagg gtaaagtttg tgatttttct ttatcattgc gatcaccatc     3660

tgataccgta aggagtgcac ttgtttggaa gttctgactt ctctgatctg tcttggtcgt     3720

ttgtgttata aaaccaaagt tctctacaga ctttattttt gtacaatatc attttgtaac     3780

tttttacaaa taaaaactca tttctattgc                                      3810


<210>  2
<211>  3655
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens glial cell derived neurotrophic factor (GDNF)

<400>  2
catacaggcc aaaagtctcc aagtccctgc taacttcttg ctctcgcaac agaataccta       60

tttaggtggg aagaatgagg tgtgggcggc aggctgggtg ccgccgccgg acgggacttt      120

aagatgaagt tatgggatgt cgtggctgtc tgcctggtgc tgctccacac cgcgtccgcc      180

ttcccgctgc ccgccgcaaa tatgccagag gattatcctg atcagttcga tgatgtcatg      240

gattttattc aagccaccat taaaagactg aaaaggtcac cagataaaca aatggcagtg      300

cttcctagaa gagagcggaa tcggcaggct gcagctgcca acccagagaa ttccagagga      360

aaaggtcgga gaggccagag gggcaaaaac cggggttgtg tcttaactgc aatacattta      420

aatgtcactg acttgggtct gggctatgaa accaaggagg aactgatttt taggtactgc      480

agcggctctt gcgatgcagc tgagacaacg tacgacaaaa tattgaaaaa cttatccaga      540

aatagaaggc tggtgagtga caaagtaggg caggcatgtt gcagacccat cgcctttgat      600

gatgacctgt cgtttttaga tgataacctg gtttaccata ttctaagaaa gcattccgct      660

aaaaggtgtg gatgtatctg actccggctc cagagactgc tgtgtattgc attcctgcta      720

cagtgcaaag aaagggacca aggttcccag gaaatgtttg cccagaatgg aagatgagga      780

ccaaggaggc ggaggaggag gaagaagaag aggaggagga ggaggaggag gaggaggagg      840

aggaaggcag ccatcatggg agcctggtag agggagatcc agctacagac aactggacag      900

gagagagaga aaacagccct ctggattctc caggatggca gccgatgtca ctagaagctc      960

agggctgatg ttcctggttg gctattgcca ccatttcagc tgatacagtc caccatcact     1020

gattaccggc gcggttgcgg tggatgcact tgaaccaaac cagtgtatct cctgtgattt     1080

gttttcatgt gtccgaagac accagggaaa cagagatcct ggtgttgttc cttgttatta     1140

cgttttactg ctgaaagtaa gaggtttatt tttctgtcac tcagtggaga cataccctgg     1200

aaaggagagg ggaaaaaaaa agcaaagata caagagataa tcacctttgc atttgaaagt     1260

tgaggcccga ggtttactac aaccagcatt tttgccaacg gttggtgatt gatttccatc     1320

acggtgtgtg gggtgggaag aagttggcta ggaaccaaaa aggctgtgct catgattaaa     1380

cacaaacctg aaggtatttc ctttatgtcc ttggaaacag gaaacgagtt gtggttttcg     1440

ccagcattct tgtaggagag aatcggggaa ggccccgaac tgcccccggg cagggagagc     1500

ccctcaggcc tgttggttta cagagagaca gatgttacat aaccagctcc gttgatgcgt     1560

ggtcaccagt gaccagagaa gctactcgat gcaatgcatc tgtttcagat acagaaatat     1620

agagaagata tttattgaaa tttaagttat tgttatttat taccgttcac taatgaattt     1680

ctcttttttc ccttatttat taaagtttct tttcaaaggt gccaaagtat atgtgctcgc     1740

aaaatgcaaa gaaaggtgac aaaaggaaat ttgaattggg aacaagggtc catgcttttc     1800

aaagtattaa aaagtttttt gccaggcaaa aatcacttac tttacctttt taagaaaatt     1860

tgtcattaat tttccccaga tttcagcatt tttcccaatt tttatttgtg gagcatctca     1920

ggcaagcccc ctttcctgga gcagcgtgca gagaccactg gcacttgact ttatttcttc     1980

cttgctccat tgctgaacag aaatgtcgtg ggctccactt cctgttgtct ttaagctctt     2040

agtcccctcc acgtatacct atctgtacta tgcataacca tatgtagaaa aggttcagtt     2100

ccttttagta ggtagtcctg gatttaatgc tgacctaaaa gtaatgtcga caatgctgtc     2160

aggtagctgc cgttctaccg actccctcca tccctgccca cccactgccc tcccgagaat     2220

atgctggctg cccagtgcag cccgggagac acaggggcct tccagaggta gggtctacca     2280

ggtcctgtac aacccctggg ctgtcaccgg gggtcaacag ctgctgctcc tatataccca     2340

aacacctgac agctccctgg ggagcagatg gctgagaagg gtgctgagga agccatattg     2400

ggaccagcca cagccacaca catggagcct catacttagg agcgtgctgc ctttaaatga     2460

aggtggtcgg ggccagtgca gcggctcaca cccataatcc caacactttg gaaagccaag     2520

gtgggaggat ctcttgaacc caggagtttg agaccagctt gggcaacata gggagaccct     2580

gtctctacag aaactttaaa aattaggcag gcatgatggt gcacacctgt ggtcccagct     2640

actcaagagg ctgaaggagg atcacttgag tccagaaggt cgaggctgca gtgagctgtg     2700

atcatgccac tgcactccag cctaagtgac agtgcggtac cctgtctcaa aaaaaaaaaa     2760

aaaaaaaaaa agaggttgga gcaggaggaa gcataggggc gggaacagcc acctcctcca     2820

tgccctagat tgtgaattta tcgggcagcc aacacatgta tgacacacta ggccctgtat     2880

tacagcttgt tacgcatttc ataaaaggga ttttcattaa ggagataatc tattactacc     2940

taccttagtg gctactagta taaaactatg acagatttag caattaaatg aaatactggc     3000

ctccatcaaa taatcatagt aacaagaagc agcagttacc agacatctga tccccttccc     3060

ccaaaatacc caaattcttc atggttctgc ccttctctgt cctttctgct ccccttgctc     3120

gcctgggaaa tggaggaaag gccttccctc tcacactgtc ttgggatctt gctgagaatt     3180

cagactgctc gaaacagtga caaaccccag ccatccagtc attcgtggag cacaatttgg     3240

atgtggcccc aggggcatct gtcccattca gagaaccttg gcagtgcgat ggccactgtt     3300

cccaggcttc aacctcagtg acccccccca acaactcccc atggagagtc cctgcccaaa     3360

aaagctgtag gatccaaggg gtgtcaatag ctcgttcccg gcatcaccta cacaccacaa     3420

gcaggtttta atggaagcaa gttgctccac caaatccaca aaagggtaaa gtttgtgatt     3480

tttctttatc attgcgatca ccatctgata ccgtaaggag tgcacttgtt tggaagttct     3540

gacttctctg atctgtcttg gtcgtttgtg ttataaaacc aaagttctct acagacttta     3600

tttttgtaca atatcatttt gtaacttttt acaaataaaa actcatttct attgc          3655


<210>  3
<211>  3830
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens glial cell derived neurotrophic factor (GDNF)

<400>  3
ccaaagcgtc cgagactggg tacagtcgtc caggcgtgac gggggcgcgg ggagccagtg       60

actcctctgg gaggggaagg gattagggcc agaatctctc aaaggtgcaa aaatccagtc      120

aagagagggt tttcgggtat accacggagg attaaaactt tcaagacaaa tgcagtcttt      180

gcctaacagc aatggtgccg ccgccggacg ggactttaag atgaagttat gggatgtcgt      240

ggctgtctgc ctggtgctgc tccacaccgc gtccgccttc ccgctgcccg ccggtaagag      300

gcctcccgag gcgcccgccg aagaccgctc cctcggccgc cgccgcgcgc ccttcgcgct      360

gagcagtgac tcaaatatgc cagaggatta tcctgatcag ttcgatgatg tcatggattt      420

tattcaagcc accattaaaa gactgaaaag gtcaccagat aaacaaatgg cagtgcttcc      480

tagaagagag cggaatcggc aggctgcagc tgccaaccca gagaattcca gaggaaaagg      540

tcggagaggc cagaggggca aaaaccgggg ttgtgtctta actgcaatac atttaaatgt      600

cactgacttg ggtctgggct atgaaaccaa ggaggaactg atttttaggt actgcagcgg      660

ctcttgcgat gcagctgaga caacgtacga caaaatattg aaaaacttat ccagaaatag      720

aaggctggtg agtgacaaag tagggcaggc atgttgcaga cccatcgcct ttgatgatga      780

cctgtcgttt ttagatgata acctggttta ccatattcta agaaagcatt ccgctaaaag      840

gtgtggatgt atctgactcc ggctccagag actgctgtgt attgcattcc tgctacagtg      900

caaagaaagg gaccaaggtt cccaggaaat gtttgcccag aatggaagat gaggaccaag      960

gaggcggagg aggaggaaga agaagaggag gaggaggagg aggaggagga ggaggaggaa     1020

ggcagccatc atgggagcct ggtagaggga gatccagcta cagacaactg gacaggagag     1080

agagaaaaca gccctctgga ttctccagga tggcagccga tgtcactaga agctcagggc     1140

tgatgttcct ggttggctat tgccaccatt tcagctgata cagtccacca tcactgatta     1200

ccggcgcggt tgcggtggat gcacttgaac caaaccagtg tatctcctgt gatttgtttt     1260

catgtgtccg aagacaccag ggaaacagag atcctggtgt tgttccttgt tattacgttt     1320

tactgctgaa agtaagaggt ttatttttct gtcactcagt ggagacatac cctggaaagg     1380

agaggggaaa aaaaaagcaa agatacaaga gataatcacc tttgcatttg aaagttgagg     1440

cccgaggttt actacaacca gcatttttgc caacggttgg tgattgattt ccatcacggt     1500

gtgtggggtg ggaagaagtt ggctaggaac caaaaaggct gtgctcatga ttaaacacaa     1560

acctgaaggt atttccttta tgtccttgga aacaggaaac gagttgtggt tttcgccagc     1620

attcttgtag gagagaatcg gggaaggccc cgaactgccc ccgggcaggg agagcccctc     1680

aggcctgttg gtttacagag agacagatgt tacataacca gctccgttga tgcgtggtca     1740

ccagtgacca gagaagctac tcgatgcaat gcatctgttt cagatacaga aatatagaga     1800

agatatttat tgaaatttaa gttattgtta tttattaccg ttcactaatg aatttctctt     1860

ttttccctta tttattaaag tttcttttca aaggtgccaa agtatatgtg ctcgcaaaat     1920

gcaaagaaag gtgacaaaag gaaatttgaa ttgggaacaa gggtccatgc ttttcaaagt     1980

attaaaaagt tttttgccag gcaaaaatca cttactttac ctttttaaga aaatttgtca     2040

ttaattttcc ccagatttca gcatttttcc caatttttat ttgtggagca tctcaggcaa     2100

gccccctttc ctggagcagc gtgcagagac cactggcact tgactttatt tcttccttgc     2160

tccattgctg aacagaaatg tcgtgggctc cacttcctgt tgtctttaag ctcttagtcc     2220

cctccacgta tacctatctg tactatgcat aaccatatgt agaaaaggtt cagttccttt     2280

tagtaggtag tcctggattt aatgctgacc taaaagtaat gtcgacaatg ctgtcaggta     2340

gctgccgttc taccgactcc ctccatccct gcccacccac tgccctcccg agaatatgct     2400

ggctgcccag tgcagcccgg gagacacagg ggccttccag aggtagggtc taccaggtcc     2460

tgtacaaccc ctgggctgtc accgggggtc aacagctgct gctcctatat acccaaacac     2520

ctgacagctc cctggggagc agatggctga gaagggtgct gaggaagcca tattgggacc     2580

agccacagcc acacacatgg agcctcatac ttaggagcgt gctgccttta aatgaaggtg     2640

gtcggggcca gtgcagcggc tcacacccat aatcccaaca ctttggaaag ccaaggtggg     2700

aggatctctt gaacccagga gtttgagacc agcttgggca acatagggag accctgtctc     2760

tacagaaact ttaaaaatta ggcaggcatg atggtgcaca cctgtggtcc cagctactca     2820

agaggctgaa ggaggatcac ttgagtccag aaggtcgagg ctgcagtgag ctgtgatcat     2880

gccactgcac tccagcctaa gtgacagtgc ggtaccctgt ctcaaaaaaa aaaaaaaaaa     2940

aaaaaagagg ttggagcagg aggaagcata ggggcgggaa cagccacctc ctccatgccc     3000

tagattgtga atttatcggg cagccaacac atgtatgaca cactaggccc tgtattacag     3060

cttgttacgc atttcataaa agggattttc attaaggaga taatctatta ctacctacct     3120

tagtggctac tagtataaaa ctatgacaga tttagcaatt aaatgaaata ctggcctcca     3180

tcaaataatc atagtaacaa gaagcagcag ttaccagaca tctgatcccc ttcccccaaa     3240

atacccaaat tcttcatggt tctgcccttc tctgtccttt ctgctcccct tgctcgcctg     3300

ggaaatggag gaaaggcctt ccctctcaca ctgtcttggg atcttgctga gaattcagac     3360

tgctcgaaac agtgacaaac cccagccatc cagtcattcg tggagcacaa tttggatgtg     3420

gccccagggg catctgtccc attcagagaa ccttggcagt gcgatggcca ctgttcccag     3480

gcttcaacct cagtgacccc ccccaacaac tccccatgga gagtccctgc ccaaaaaagc     3540

tgtaggatcc aaggggtgtc aatagctcgt tcccggcatc acctacacac cacaagcagg     3600

ttttaatgga agcaagttgc tccaccaaat ccacaaaagg gtaaagtttg tgatttttct     3660

ttatcattgc gatcaccatc tgataccgta aggagtgcac ttgtttggaa gttctgactt     3720

ctctgatctg tcttggtcgt ttgtgttata aaaccaaagt tctctacaga ctttattttt     3780

gtacaatatc attttgtaac tttttacaaa taaaaactca tttctattgc                3830


<210>  4
<211>  3752
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens glial cell derived neurotrophic factor (GDNF)

<400>  4
ccaaagcgtc cgagactggg tacagtcgtc caggcgtgac gggggcgcgg ggagccagtg       60

actcctctgg gaggggaagg gattagggcc agaatctctc aaaggtgcaa aaatccagtc      120

aagagagggt tttcgggtat accacggagg attaaaactt tcaagacaaa tgcagtcttt      180

gcctaacagc aatggtgccg ccgccggacg ggactttaag atgaagttat gggatgtcgt      240

ggctgtctgc ctggtgctgc tccacaccgc gtccgccttc ccgctgcccg ccgcaaatat      300

gccagaggat tatcctgatc agttcgatga tgtcatggat tttattcaag ccaccattaa      360

aagactgaaa aggtcaccag ataaacaaat ggcagtgctt cctagaagag agcggaatcg      420

gcaggctgca gctgccaacc cagagaattc cagaggaaaa ggtcggagag gccagagggg      480

caaaaaccgg ggttgtgtct taactgcaat acatttaaat gtcactgact tgggtctggg      540

ctatgaaacc aaggaggaac tgatttttag gtactgcagc ggctcttgcg atgcagctga      600

gacaacgtac gacaaaatat tgaaaaactt atccagaaat agaaggctgg tgagtgacaa      660

agtagggcag gcatgttgca gacccatcgc ctttgatgat gacctgtcgt ttttagatga      720

taacctggtt taccatattc taagaaagca ttccgctaaa aggtgtggat gtatctgact      780

ccggctccag agactgctgt gtattgcatt cctgctacag tgcaaagaaa gggaccaagg      840

ttcccaggaa atgtttgccc agaatggaag atgaggacca aggaggcgga ggaggaggaa      900

gaagaagagg aggaggagga ggaggaggag gaggaggagg aaggcagcca tcatgggagc      960

ctggtagagg gagatccagc tacagacaac tggacaggag agagagaaaa cagccctctg     1020

gattctccag gatggcagcc gatgtcacta gaagctcagg gctgatgttc ctggttggct     1080

attgccacca tttcagctga tacagtccac catcactgat taccggcgcg gttgcggtgg     1140

atgcacttga accaaaccag tgtatctcct gtgatttgtt ttcatgtgtc cgaagacacc     1200

agggaaacag agatcctggt gttgttcctt gttattacgt tttactgctg aaagtaagag     1260

gtttattttt ctgtcactca gtggagacat accctggaaa ggagagggga aaaaaaaagc     1320

aaagatacaa gagataatca cctttgcatt tgaaagttga ggcccgaggt ttactacaac     1380

cagcattttt gccaacggtt ggtgattgat ttccatcacg gtgtgtgggg tgggaagaag     1440

ttggctagga accaaaaagg ctgtgctcat gattaaacac aaacctgaag gtatttcctt     1500

tatgtccttg gaaacaggaa acgagttgtg gttttcgcca gcattcttgt aggagagaat     1560

cggggaaggc cccgaactgc ccccgggcag ggagagcccc tcaggcctgt tggtttacag     1620

agagacagat gttacataac cagctccgtt gatgcgtggt caccagtgac cagagaagct     1680

actcgatgca atgcatctgt ttcagataca gaaatataga gaagatattt attgaaattt     1740

aagttattgt tatttattac cgttcactaa tgaatttctc ttttttccct tatttattaa     1800

agtttctttt caaaggtgcc aaagtatatg tgctcgcaaa atgcaaagaa aggtgacaaa     1860

aggaaatttg aattgggaac aagggtccat gcttttcaaa gtattaaaaa gttttttgcc     1920

aggcaaaaat cacttacttt acctttttaa gaaaatttgt cattaatttt ccccagattt     1980

cagcattttt cccaattttt atttgtggag catctcaggc aagccccctt tcctggagca     2040

gcgtgcagag accactggca cttgacttta tttcttcctt gctccattgc tgaacagaaa     2100

tgtcgtgggc tccacttcct gttgtcttta agctcttagt cccctccacg tatacctatc     2160

tgtactatgc ataaccatat gtagaaaagg ttcagttcct tttagtaggt agtcctggat     2220

ttaatgctga cctaaaagta atgtcgacaa tgctgtcagg tagctgccgt tctaccgact     2280

ccctccatcc ctgcccaccc actgccctcc cgagaatatg ctggctgccc agtgcagccc     2340

gggagacaca ggggccttcc agaggtaggg tctaccaggt cctgtacaac ccctgggctg     2400

tcaccggggg tcaacagctg ctgctcctat atacccaaac acctgacagc tccctgggga     2460

gcagatggct gagaagggtg ctgaggaagc catattggga ccagccacag ccacacacat     2520

ggagcctcat acttaggagc gtgctgcctt taaatgaagg tggtcggggc cagtgcagcg     2580

gctcacaccc ataatcccaa cactttggaa agccaaggtg ggaggatctc ttgaacccag     2640

gagtttgaga ccagcttggg caacataggg agaccctgtc tctacagaaa ctttaaaaat     2700

taggcaggca tgatggtgca cacctgtggt cccagctact caagaggctg aaggaggatc     2760

acttgagtcc agaaggtcga ggctgcagtg agctgtgatc atgccactgc actccagcct     2820

aagtgacagt gcggtaccct gtctcaaaaa aaaaaaaaaa aaaaaaaaga ggttggagca     2880

ggaggaagca taggggcggg aacagccacc tcctccatgc cctagattgt gaatttatcg     2940

ggcagccaac acatgtatga cacactaggc cctgtattac agcttgttac gcatttcata     3000

aaagggattt tcattaagga gataatctat tactacctac cttagtggct actagtataa     3060

aactatgaca gatttagcaa ttaaatgaaa tactggcctc catcaaataa tcatagtaac     3120

aagaagcagc agttaccaga catctgatcc ccttccccca aaatacccaa attcttcatg     3180

gttctgccct tctctgtcct ttctgctccc cttgctcgcc tgggaaatgg aggaaaggcc     3240

ttccctctca cactgtcttg ggatcttgct gagaattcag actgctcgaa acagtgacaa     3300

accccagcca tccagtcatt cgtggagcac aatttggatg tggccccagg ggcatctgtc     3360

ccattcagag aaccttggca gtgcgatggc cactgttccc aggcttcaac ctcagtgacc     3420

ccccccaaca actccccatg gagagtccct gcccaaaaaa gctgtaggat ccaaggggtg     3480

tcaatagctc gttcccggca tcacctacac accacaagca ggttttaatg gaagcaagtt     3540

gctccaccaa atccacaaaa gggtaaagtt tgtgattttt ctttatcatt gcgatcacca     3600

tctgataccg taaggagtgc acttgtttgg aagttctgac ttctctgatc tgtcttggtc     3660

gtttgtgtta taaaaccaaa gttctctaca gactttattt ttgtacaata tcattttgta     3720

actttttaca aataaaaact catttctatt gc                                   3752


<210>  5
<211>  485
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  cDNA encoding isoform 1

<400>  5
caaatatgcc agaggattat cctgatcagt tcgatgatgt catggatttt attcaagcca       60

ccattaaaag actgaaaagg tcaccagata aacaaatggc agtgcttcct agaagagagc      120

ggaatcggca ggctgcagct gccaacccag agaattccag aggaaaaggt cggagaggcc      180

agaggggcaa aaaccggggt tgtgtcttaa ctgcaataca tttaaatgtc actgacttgg      240

gtctgggcta tgaaaccaag gaggaactga tttttaggta ctgcagcggc tcttgcgatg      300

cagctgagac aacgtacgac aaaatattga aaaacttatc cagaaataga aggctggtga      360

gtgacaaagt agggcaggca tgttgcagac ccatcgcctt tgatgatgac ctgtcgtttt      420

tagatgataa cctggtttac catattctaa gaaagcattc cgctaaaagg tgtggatgta      480

tctga                                                                  485


<210>  6
<211>  185
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  glial cell line-derived neurotrophic factor isoform 2 
       preproprotein

<400>  6

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr Pro 
            20                  25                  30          


Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg 
        35                  40                  45              


Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu 
    50                  55                  60                  


Arg Asn Arg Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys 
65                  70                  75                  80  


Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala 
                85                  90                  95      


Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu 
            100                 105                 110         


Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr 
        115                 120                 125             


Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val 
    130                 135                 140                 


Ser Asp Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp 
145                 150                 155                 160 


Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys 
                165                 170                 175     


His Ser Ala Lys Arg Cys Gly Cys Ile 
            180                 185 


<210>  7
<211>  211
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  glial cell line-derived neurotrophic factor isoform 1 
       preproprotein

<400>  7

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  8
<211>  228
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  glial cell line-derived neurotrophic factor isoform 3 
       preproprotein

<400>  8

Met Gln Ser Leu Pro Asn Ser Asn Gly Ala Ala Ala Gly Arg Asp Phe 
1               5                   10                  15      


Lys Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His 
            20                  25                  30          


Thr Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala 
        35                  40                  45              


Pro Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu 
    50                  55                  60                  


Ser Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp 
65                  70                  75                  80  


Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro 
                85                  90                  95      


Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala 
            100                 105                 110         


Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln 
        115                 120                 125             


Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val 
    130                 135                 140                 


Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg 
145                 150                 155                 160 


Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile 
                165                 170                 175     


Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly 
            180                 185                 190         


Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu 
        195                 200                 205             


Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg 
    210                 215                 220                 


Cys Gly Cys Ile 
225             


<210>  9
<211>  202
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  glial cell line-derived neurotrophic factor isoform 4 
       preproprotein

<400>  9

Met Gln Ser Leu Pro Asn Ser Asn Gly Ala Ala Ala Gly Arg Asp Phe 
1               5                   10                  15      


Lys Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His 
            20                  25                  30          


Thr Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr 
        35                  40                  45              


Pro Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys 
    50                  55                  60                  


Arg Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg 
65                  70                  75                  80  


Glu Arg Asn Arg Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly 
                85                  90                  95      


Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr 
            100                 105                 110         


Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys 
        115                 120                 125             


Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu 
    130                 135                 140                 


Thr Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu 
145                 150                 155                 160 


Val Ser Asp Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp 
                165                 170                 175     


Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg 
            180                 185                 190         


Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
        195                 200         


<210>  10
<211>  211
<212>  PRT
<213>  Mouse sp.


<220>
<221>  misc_feature
<223>  mouse GDN sequence

<400>  10

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Leu Leu Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp His Ser Leu Gly His Arg Arg Val Pro Phe Ala Leu Thr 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Ala Ala Ala Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Ser Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Glu Ser Ala Glu Thr Met Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Ser Arg Arg Leu Thr Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Val Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  11
<211>  211
<212>  PRT
<213>  Rat sp.


<220>
<221>  misc_feature
<223>  Rat GDN sequence

<400>  11

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Leu Leu Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp His Ser Leu Gly His Arg Arg Val Pro Phe Ala Leu Thr 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Ala Ala Ala Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Ser Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Glu Ala Ala Glu Thr Met Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Ser Arg Arg Leu Thr Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Val Ala Phe Asp Asp Asp Leu Trp Phe Leu Asp 
            180                 185                 190         


Asp Ser Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  12
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from human and mouse GDN sequences

<400>  12

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Glu Ala Pro Ala Glu 
            20                  25                  30          


Asp Ser Leu Gly Arg Arg Pro Phe Ala Leu Ser Asp Ser Asn Met Pro 
        35                  40                  45              


Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala 
    50                  55                  60                  


Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp Lys Gln Ala Leu Pro Arg 
65                  70                  75                  80  


Arg Glu Arg Asn Arg Gln Ala Ala Ala Ala Pro Glu Asn Ser Arg Gly 
                85                  90                  95      


Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr 
            100                 105                 110         


Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys 
        115                 120                 125             


Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Ala Glu Thr Tyr 
    130                 135                 140                 


Asp Lys Ile Leu Lys Asn Leu Ser Arg Arg Arg Leu Ser Asp Lys Val 
145                 150                 155                 160 


Gly Gln Ala Cys Cys Arg Pro Ala Phe Asp Asp Asp Leu Ser Phe Leu 
                165                 170                 175     


Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg 
            180                 185                 190         


Cys Gly Cys Ile 
        195     


<210>  13
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from human and rat GDN sequences

<400>  13

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Glu Ala Pro Ala Glu 
            20                  25                  30          


Asp Ser Leu Gly Arg Arg Pro Phe Ala Leu Ser Asp Ser Asn Met Pro 
        35                  40                  45              


Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala 
    50                  55                  60                  


Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp Lys Gln Ala Leu Pro Arg 
65                  70                  75                  80  


Arg Glu Arg Asn Arg Gln Ala Ala Ala Ala Pro Glu Asn Ser Arg Gly 
                85                  90                  95      


Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr 
            100                 105                 110         


Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys 
        115                 120                 125             


Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Ala Ala Glu Thr 
    130                 135                 140                 


Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Arg Arg Leu Ser Asp Lys 
145                 150                 155                 160 


Val Gly Gln Ala Cys Cys Arg Pro Ala Phe Asp Asp Asp Leu Phe Leu 
                165                 170                 175     


Asp Asp Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
            180                 185                 190         


Gly Cys Ile 
        195 


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Fgfr2-Forward

<400>  14
ctctctacgt catagttgaa tatg                                              24


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Fgfr2-Reverse

<400>  15
atatccctgg ccaggccaaa gtct                                              24


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Ret-Forward

<400>  16
agatgtttat gaggaagatt ccta                                              24


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Ret-Reverse

<400>  17
tcctcgctgc agttgtctgg cctc                                              24


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Col4a1-Forward

<400>  18
atgccctttc tcttctgcaa                                                   20


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Csf1-Forward

<400>  19
gatccctgag tctgtcttcc acct                                              24


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Csf1-Reverse

<400>  20
cagttccacc tgtctgtcct catcc                                             25


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Csf1r-Forward

<400>  21
gtaaagtgga tggccccaga gagc                                              24


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Csf1r-Reverse

<400>  22
taggctccag gtcccagcag gactg                                             25


<210>  23
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: c-Myc-Forward

<400>  23
cagctcgccc aaatcctgta cctcgt                                            26


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: c-Myc- Reverse

<400>  24
cagacaccac atcaatttct tcctc                                             25


<210>  25
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Notch1 -Forward

<400>  25
tgaagaacgg agccaacaag gacatgc                                           27


<210>  26
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Notch1- Reverse

<400>  26
gcaatcggtc catgtgatcc gtgatgt                                           27


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer: Col4a1-Reverse

<400>  27
ctgcggaatc tgaatggtct                                                   20


