                         SEQUENCE LISTING

<110>  Brasier, Allan
       Wiktorowicz, John E.
       Ju, Hyunsu
       Garg, Nisha Jain
 
<120>  BIOMARKERS FOR CHAGAS DISEASE RELATED CARDIOMYOPATHY

<130>  UTMB0388WO

<150>  61775676
<151>  2013-03-10

<150>  13470209
<151>  2012-05-11

<150>  61518736
<151>  2011-05-11

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  1134
<212>  PRT
<213>  Homo sapien

<400>  1

Met Pro Val Phe His Thr Arg Thr Ile Glu Ser Ile Leu Glu Pro Val 
1               5                   10                  15      


Ala Gln Gln Ile Ser His Leu Val Ile Met His Glu Glu Gly Glu Val 
            20                  25                  30          


Asp Gly Lys Ala Ile Pro Asp Leu Thr Ala Pro Val Ala Ala Val Gln 
        35                  40                  45              


Ala Ala Val Ser Asn Leu Val Arg Val Gly Lys Glu Thr Val Gln Thr 
    50                  55                  60                  


Thr Glu Asp Gln Ile Leu Lys Arg Asp Met Pro Pro Ala Phe Ile Lys 
65                  70                  75                  80  


Val Glu Asn Ala Cys Thr Lys Leu Val Gln Ala Ala Gln Met Leu Gln 
                85                  90                  95      


Ser Asp Pro Tyr Ser Val Pro Ala Arg Asp Tyr Leu Ile Asp Gly Ser 
            100                 105                 110         


Arg Gly Ile Leu Ser Gly Thr Ser Asp Leu Leu Leu Thr Phe Asp Glu 
        115                 120                 125             


Ala Glu Val Arg Lys Ile Ile Arg Val Cys Lys Gly Ile Leu Glu Tyr 
    130                 135                 140                 


Leu Thr Val Ala Glu Val Val Glu Thr Met Glu Asp Leu Val Thr Tyr 
145                 150                 155                 160 


Thr Lys Asn Leu Gly Pro Gly Met Thr Lys Met Ala Lys Met Ile Asp 
                165                 170                 175     


Glu Arg Gln Gln Glu Leu Thr His Gln Glu His Arg Val Met Leu Val 
            180                 185                 190         


Asn Ser Met Asn Thr Val Lys Glu Leu Leu Pro Val Leu Ile Ser Ala 
        195                 200                 205             


Met Lys Ile Phe Val Thr Thr Lys Asn Ser Lys Asn Gln Gly Ile Glu 
    210                 215                 220                 


Glu Ala Leu Lys Asn Arg Asn Phe Thr Val Glu Lys Met Ser Ala Glu 
225                 230                 235                 240 


Ile Asn Glu Ile Ile Arg Val Leu Gln Leu Thr Ser Trp Asp Glu Asp 
                245                 250                 255     


Ala Trp Ala Ser Lys Asp Thr Glu Ala Met Lys Arg Ala Leu Ala Ser 
            260                 265                 270         


Ile Asp Ser Lys Leu Asn Gln Ala Lys Gly Trp Leu Arg Asp Pro Ser 
        275                 280                 285             


Ala Ser Pro Gly Asp Ala Gly Glu Gln Ala Ile Arg Gln Ile Leu Asp 
    290                 295                 300                 


Glu Ala Gly Lys Val Gly Glu Leu Cys Ala Gly Lys Glu Arg Arg Glu 
305                 310                 315                 320 


Ile Leu Gly Thr Cys Lys Met Leu Gly Gln Met Thr Asp Gln Val Ala 
                325                 330                 335     


Asp Leu Arg Ala Arg Gly Gln Gly Ser Ser Pro Val Ala Met Gln Lys 
            340                 345                 350         


Ala Gln Gln Val Ser Gln Gly Leu Asp Val Leu Thr Ala Lys Val Glu 
        355                 360                 365             


Asn Ala Ala Arg Lys Leu Glu Ala Met Thr Asn Ser Lys Gln Ser Ile 
    370                 375                 380                 


Ala Lys Lys Ile Asp Ala Ala Gln Asn Trp Leu Ala Asp Pro Asn Gly 
385                 390                 395                 400 


Gly Pro Glu Gly Glu Glu Gln Ile Arg Gly Ala Leu Ala Glu Ala Arg 
                405                 410                 415     


Lys Ile Ala Glu Leu Cys Asp Asp Pro Lys Glu Arg Asp Asp Ile Leu 
            420                 425                 430         


Arg Ser Leu Gly Glu Ile Ser Ala Leu Thr Ser Lys Leu Ala Asp Leu 
        435                 440                 445             


Arg Arg Gln Gly Lys Gly Asp Ser Pro Glu Ala Arg Ala Leu Ala Lys 
    450                 455                 460                 


Gln Val Ala Thr Ala Leu Gln Asn Leu Gln Thr Lys Thr Asn Arg Ala 
465                 470                 475                 480 


Val Ala Asn Ser Arg Pro Ala Lys Ala Ala Val His Leu Glu Gly Lys 
                485                 490                 495     


Ile Glu Gln Ala Gln Arg Trp Ile Asp Asn Pro Thr Val Asp Asp Arg 
            500                 505                 510         


Gly Val Gly Gln Ala Ala Ile Arg Gly Leu Val Ala Glu Gly His Arg 
        515                 520                 525             


Leu Ala Asn Val Met Met Gly Pro Tyr Arg Gln Asp Leu Leu Ala Lys 
    530                 535                 540                 


Cys Asp Arg Val Asp Gln Leu Thr Ala Gln Leu Ala Asp Leu Ala Ala 
545                 550                 555                 560 


Arg Gly Glu Gly Glu Ser Pro Gln Ala Arg Ala Leu Ala Ser Gln Leu 
                565                 570                 575     


Gln Asp Ser Leu Lys Asp Leu Lys Ala Arg Met Gln Glu Ala Met Thr 
            580                 585                 590         


Gln Glu Val Ser Asp Val Phe Ser Asp Thr Thr Thr Pro Ile Lys Leu 
        595                 600                 605             


Leu Ala Val Ala Ala Thr Ala Pro Pro Asp Ala Pro Asn Arg Glu Glu 
    610                 615                 620                 


Val Phe Asp Glu Arg Ala Ala Asn Phe Glu Asn His Ser Gly Lys Leu 
625                 630                 635                 640 


Gly Ala Thr Ala Glu Lys Ala Ala Ala Val Gly Thr Ala Asn Lys Ser 
                645                 650                 655     


Thr Val Glu Gly Ile Gln Ala Ser Val Lys Thr Ala Arg Glu Leu Thr 
            660                 665                 670         


Pro Gln Val Val Ser Ala Ala Arg Ile Leu Leu Arg Asn Pro Gly Asn 
        675                 680                 685             


Gln Ala Ala Tyr Glu His Phe Glu Thr Met Lys Asn Gln Trp Ile Asp 
    690                 695                 700                 


Asn Val Glu Lys Met Thr Gly Leu Val Asp Glu Ala Ile Asp Thr Lys 
705                 710                 715                 720 


Ser Leu Leu Asp Ala Ser Glu Glu Ala Ile Lys Lys Asp Leu Asp Lys 
                725                 730                 735     


Cys Lys Val Ala Met Ala Asn Ile Gln Pro Gln Met Leu Val Ala Gly 
            740                 745                 750         


Ala Thr Ser Ile Ala Arg Arg Ala Asn Arg Ile Leu Leu Val Ala Lys 
        755                 760                 765             


Arg Glu Val Glu Asn Ser Glu Asp Pro Lys Phe Arg Glu Ala Val Lys 
    770                 775                 780                 


Ala Ala Ser Asp Glu Leu Ser Lys Thr Ile Ser Pro Met Val Met Asp 
785                 790                 795                 800 


Ala Lys Ala Val Ala Gly Asn Ile Ser Asp Pro Gly Leu Gln Lys Ser 
                805                 810                 815     


Phe Leu Asp Ser Gly Tyr Arg Ile Leu Gly Ala Val Ala Lys Val Arg 
            820                 825                 830         


Glu Ala Phe Gln Pro Gln Glu Pro Asp Phe Pro Pro Pro Pro Pro Asp 
        835                 840                 845             


Leu Glu Gln Leu Arg Leu Thr Asp Glu Leu Ala Pro Pro Lys Pro Pro 
    850                 855                 860                 


Leu Pro Glu Gly Glu Val Pro Pro Pro Arg Pro Pro Pro Pro Glu Glu 
865                 870                 875                 880 


Lys Asp Glu Glu Phe Pro Glu Gln Lys Ala Gly Glu Val Ile Asn Gln 
                885                 890                 895     


Pro Met Met Met Ala Ala Arg Gln Leu His Asp Glu Ala Arg Lys Trp 
            900                 905                 910         


Ser Ser Lys Pro Gly Ile Pro Ala Ala Glu Val Gly Ile Gly Val Val 
        915                 920                 925             


Ala Glu Ala Asp Ala Ala Asp Ala Ala Gly Phe Pro Val Pro Pro Asp 
    930                 935                 940                 


Met Glu Asp Asp Tyr Glu Pro Glu Leu Leu Leu Met Pro Ser Asn Gln 
945                 950                 955                 960 


Pro Val Asn Gln Pro Ile Leu Ala Ala Ala Gln Ser Leu His Arg Glu 
                965                 970                 975     


Ala Thr Lys Trp Ser Ser Lys Gly Asn Asp Ile Ile Ala Ala Ala Lys 
            980                 985                 990         


Arg Met Ala Leu Leu Met Ala Glu  Met Ser Arg Leu Val  Arg Gly Gly 
        995                 1000                 1005             


Ser Gly  Thr Lys Arg Ala Leu  Ile Gln Cys Ala Lys  Asp Ile Ala 
    1010                 1015                 1020             


Lys Ala  Ser Asp Glu Val Thr  Arg Leu Ala Lys Glu  Val Ala Lys 
    1025                 1030                 1035             


Gln Cys  Thr Asp Lys Arg Ile  Arg Thr Asn Leu Leu  Gln Val Cys 
    1040                 1045                 1050             


Glu Arg  Ile Pro Thr Ile Ser  Thr Gln Leu Lys Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Lys  Ala Thr Met Leu Gly  Arg Thr Asn Ile Ser  Asp Glu Glu 
    1070                 1075                 1080             


Ser Glu  Gln Ala Thr Glu Met  Leu Val His Asn Ala  Gln Asn Leu 
    1085                 1090                 1095             


Met Gln  Ser Val Lys Glu Thr  Val Arg Glu Ala Glu  Ala Ala Ser 
    1100                 1105                 1110             


Ile Lys  Ile Arg Thr Asp Ala  Gly Phe Thr Leu Arg  Trp Val Arg 
    1115                 1120                 1125             


Lys Thr  Pro Trp Tyr Gln 
    1130                 


<210>  2
<211>  454
<212>  PRT
<213>  Homo sapien


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Xaa Phe Ser Lys Phe Arg Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
1               5                   10                  15      


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
            20                  25                  30          


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
        35                  40                  45              


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
65                  70                  75                  80  


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
                85                  90                  95      


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
            100                 105                 110         


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
        115                 120                 125             


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
    130                 135                 140                 


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
145                 150                 155                 160 


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
                165                 170                 175     


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
            180                 185                 190         


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
        195                 200                 205             


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
    210                 215                 220                 


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
225                 230                 235                 240 


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
                245                 250                 255     


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
            260                 265                 270         


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
        275                 280                 285             


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
    290                 295                 300                 


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
305                 310                 315                 320 


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
                325                 330                 335     


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
            340                 345                 350         


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
        355                 360                 365             


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
    370                 375                 380                 


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
385                 390                 395                 400 


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
                405                 410                 415     


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
            420                 425                 430         


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
        435                 440                 445             


Gln Ala Ala Leu Gly Leu 
    450                 


<210>  3
<211>  1039
<212>  PRT
<213>  Homo sapien

<400>  3

Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 
            20                  25                  30          


Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 
        35                  40                  45              


Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 
    50                  55                  60                  


Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 
65                  70                  75                  80  


Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 
                85                  90                  95      


Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 
            100                 105                 110         


Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 
        115                 120                 125             


Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 
    130                 135                 140                 


Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 
145                 150                 155                 160 


Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 
                165                 170                 175     


Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 
            180                 185                 190         


Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 
        195                 200                 205             


Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 
    210                 215                 220                 


Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 
225                 230                 235                 240 


Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 
                245                 250                 255     


Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 
            260                 265                 270         


Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 
        275                 280                 285             


Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 
    290                 295                 300                 


Tyr Gln Arg Leu His Arg Leu Arg Gly Glu Gln Met Ala Ser Tyr Phe 
305                 310                 315                 320 


Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 
                325                 330                 335     


Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 
            340                 345                 350         


Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 
        355                 360                 365             


His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 
    370                 375                 380                 


Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 
385                 390                 395                 400 


Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 
                405                 410                 415     


Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 
            420                 425                 430         


Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 
        435                 440                 445             


Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 
    450                 455                 460                 


Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 
465                 470                 475                 480 


Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 
                485                 490                 495     


Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 
            500                 505                 510         


Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 
        515                 520                 525             


Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 
    530                 535                 540                 


Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 
545                 550                 555                 560 


Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 
                565                 570                 575     


His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 
            580                 585                 590         


Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 
        595                 600                 605             


Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 
    610                 615                 620                 


Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 
625                 630                 635                 640 


Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 
                645                 650                 655     


Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 
            660                 665                 670         


Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 
        675                 680                 685             


His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 
    690                 695                 700                 


Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 
705                 710                 715                 720 


Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 
                725                 730                 735     


Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 
            740                 745                 750         


Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 
        755                 760                 765             


Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 
    770                 775                 780                 


Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 
785                 790                 795                 800 


Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 
                805                 810                 815     


Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 
            820                 825                 830         


His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 
        835                 840                 845             


Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 
    850                 855                 860                 


Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 
865                 870                 875                 880 


His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 
                885                 890                 895     


Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 
            900                 905                 910         


Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 
        915                 920                 925             


Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 
    930                 935                 940                 


Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 
945                 950                 955                 960 


Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 
                965                 970                 975     


Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 
            980                 985                 990         


Arg Ala Ile Pro Ile Trp Trp Val  Leu Val Gly Val Leu  Gly Gly Leu 
        995                 1000                 1005             


Leu Leu  Leu Thr Ile Leu Val  Leu Ala Met Trp Lys  Val Gly Phe 
    1010                 1015                 1020             


Phe Lys  Arg Asn Arg Pro Pro  Leu Glu Glu Asp Asp  Glu Glu Gly 
    1025                 1030                 1035             


Glu 
    


<210>  4
<211>  745
<212>  PRT
<213>  Homo sapien

<400>  4

Met Gly Val Pro Phe Phe Ser Ser Leu Arg Cys Met Val Asp Leu Gly 
1               5                   10                  15      


Pro Cys Trp Ala Gly Gly Leu Thr Ala Glu Met Lys Leu Leu Leu Ala 
            20                  25                  30          


Leu Ala Gly Leu Leu Ala Ile Leu Ala Thr Pro Gln Pro Ser Glu Gly 
        35                  40                  45              


Ala Ala Pro Ala Val Leu Gly Glu Val Asp Thr Ser Leu Val Leu Ser 
    50                  55                  60                  


Ser Met Glu Glu Ala Lys Gln Leu Val Asp Lys Ala Tyr Lys Glu Arg 
65                  70                  75                  80  


Arg Glu Ser Ile Lys Gln Arg Leu Arg Ser Gly Ser Ala Ser Pro Met 
                85                  90                  95      


Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr Ala 
            100                 105                 110         


Val Arg Ala Ala Asp Tyr Leu His Val Ala Leu Asp Leu Leu Glu Arg 
        115                 120                 125             


Lys Leu Arg Ser Leu Trp Arg Arg Pro Phe Asn Val Thr Asp Val Leu 
    130                 135                 140                 


Thr Pro Ala Gln Leu Asn Val Leu Ser Lys Ser Ser Gly Cys Ala Tyr 
145                 150                 155                 160 


Gln Asp Val Gly Val Thr Cys Pro Glu Gln Asp Lys Tyr Arg Thr Ile 
                165                 170                 175     


Thr Gly Met Cys Asn Asn Arg Arg Ser Pro Thr Leu Gly Ala Ser Asn 
            180                 185                 190         


Arg Ala Phe Val Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Phe Ser 
        195                 200                 205             


Leu Pro Tyr Gly Trp Thr Pro Gly Val Lys Arg Asn Gly Phe Pro Val 
    210                 215                 220                 


Ala Leu Ala Arg Ala Val Ser Asn Glu Ile Val Arg Phe Pro Thr Asp 
225                 230                 235                 240 


Gln Leu Thr Pro Asp Gln Glu Arg Ser Leu Met Phe Met Gln Trp Gly 
                245                 250                 255     


Gln Leu Leu Asp His Asp Leu Asp Phe Thr Pro Glu Pro Ala Ala Arg 
            260                 265                 270         


Ala Ser Phe Val Thr Gly Val Asn Cys Glu Thr Ser Cys Val Gln Gln 
        275                 280                 285             


Pro Pro Cys Phe Pro Leu Lys Ile Pro Pro Asn Asp Pro Arg Ile Lys 
    290                 295                 300                 


Asn Gln Ala Asp Cys Ile Pro Phe Phe Arg Ser Cys Pro Ala Cys Pro 
305                 310                 315                 320 


Gly Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe 
                325                 330                 335     


Val Asp Ala Ser Met Val Tyr Gly Ser Glu Glu Pro Leu Ala Arg Asn 
            340                 345                 350         


Leu Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg 
        355                 360                 365             


Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp 
    370                 375                 380                 


Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile Pro Cys Phe Leu 
385                 390                 395                 400 


Ala Gly Asp Thr Arg Ser Ser Glu Met Pro Glu Leu Thr Ser Met His 
                405                 410                 415     


Thr Leu Leu Leu Arg Glu His Asn Arg Leu Ala Thr Glu Leu Lys Ser 
            420                 425                 430         


Leu Asn Pro Arg Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala Arg Lys 
        435                 440                 445             


Ile Val Gly Ala Met Val Gln Ile Ile Thr Tyr Arg Asp Tyr Leu Pro 
    450                 455                 460                 


Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu Pro Thr Tyr Arg 
465                 470                 475                 480 


Ser Tyr Asn Asp Ser Val Asp Pro Arg Ile Ala Asn Val Phe Thr Asn 
                485                 490                 495     


Ala Phe Arg Tyr Gly His Thr Leu Ile Gln Pro Phe Met Phe Arg Leu 
            500                 505                 510         


Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser 
        515                 520                 525             


Arg Val Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp 
    530                 535                 540                 


Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln 
545                 550                 555                 560 


Asn Gln Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Val 
                565                 570                 575     


Met Arg Ile Gly Leu Asp Leu Pro Ala Leu Asn Met Gln Arg Ser Arg 
            580                 585                 590         


Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg Phe Cys Gly Leu 
        595                 600                 605             


Pro Gln Pro Glu Thr Val Gly Gln Leu Gly Thr Val Leu Arg Asn Leu 
    610                 615                 620                 


Lys Leu Ala Arg Lys Leu Met Glu Gln Tyr Gly Thr Pro Asn Asn Ile 
625                 630                 635                 640 


Asp Ile Trp Met Gly Gly Val Ser Glu Pro Leu Lys Arg Lys Gly Arg 
                645                 650                 655     


Val Gly Pro Leu Leu Ala Cys Ile Ile Gly Thr Gln Phe Arg Lys Leu 
            660                 665                 670         


Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Glu Gly Val Phe Ser Met 
        675                 680                 685             


Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile Cys 
    690                 695                 700                 


Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn Asn Ile Phe Met Ser 
705                 710                 715                 720 


Asn Ser Tyr Pro Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu 
                725                 730                 735     


Asn Leu Ala Ser Trp Arg Glu Ala Ser 
            740                 745 


<210>  5
<211>  374
<212>  PRT
<213>  Homo sapien

<400>  5

Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met Cys 
1               5                   10                  15      


Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro Ser 
            20                  25                  30          


Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly Gln 
        35                  40                  45              


Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile Leu 
    50                  55                  60                  


Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp Asp 
65                  70                  75                  80  


Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala 
                85                  90                  95      


Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro Lys 
            100                 105                 110         


Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn Thr 
        115                 120                 125             


Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala Ser 
    130                 135                 140                 


Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr His 
145                 150                 155                 160 


Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu Arg 
                165                 170                 175     


Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile Leu 
            180                 185                 190         


Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile Val 
        195                 200                 205             


Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln 
    210                 215                 220                 


Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu 
225                 230                 235                 240 


Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys 
                245                 250                 255     


Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys Gly 
            260                 265                 270         


Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp Ile 
        275                 280                 285             


Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr Met 
    290                 295                 300                 


Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu Ala 
305                 310                 315                 320 


Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys Tyr 
                325                 330                 335     


Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe Gln 
            340                 345                 350         


Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile 
        355                 360                 365             


Val His Arg Lys Cys Phe 
    370                 


<210>  6
<211>  2429
<212>  PRT
<213>  Homo sapien

<400>  6

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
1               5                   10                  15      


Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
            20                  25                  30          


Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
        35                  40                  45              


Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
    50                  55                  60                  


Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
65                  70                  75                  80  


Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                85                  90                  95      


Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
            100                 105                 110         


Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
        115                 120                 125             


Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
    130                 135                 140                 


Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
145                 150                 155                 160 


Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                165                 170                 175     


Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
            180                 185                 190         


Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
        195                 200                 205             


Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
    210                 215                 220                 


Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
225                 230                 235                 240 


Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                245                 250                 255     


Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
            260                 265                 270         


Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
        275                 280                 285             


Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
    290                 295                 300                 


Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
305                 310                 315                 320 


Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                325                 330                 335     


Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
            340                 345                 350         


Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
        355                 360                 365             


Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
    370                 375                 380                 


Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                405                 410                 415     


Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
            420                 425                 430         


Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
        435                 440                 445             


Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
    450                 455                 460                 


Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
465                 470                 475                 480 


His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                485                 490                 495     


Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
            500                 505                 510         


Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
        515                 520                 525             


Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
    530                 535                 540                 


Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
545                 550                 555                 560 


Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                565                 570                 575     


Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
            580                 585                 590         


Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
        595                 600                 605             


Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
    610                 615                 620                 


Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
625                 630                 635                 640 


Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                645                 650                 655     


Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
            660                 665                 670         


Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
        675                 680                 685             


Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
    690                 695                 700                 


Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
705                 710                 715                 720 


Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                725                 730                 735     


Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
            740                 745                 750         


Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
        755                 760                 765             


Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
    770                 775                 780                 


Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
785                 790                 795                 800 


Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                805                 810                 815     


Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
            820                 825                 830         


Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
        835                 840                 845             


Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
    850                 855                 860                 


Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
865                 870                 875                 880 


Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                885                 890                 895     


Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
            900                 905                 910         


Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
        915                 920                 925             


Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
    930                 935                 940                 


Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
945                 950                 955                 960 


Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                965                 970                 975     


Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
            980                 985                 990         


Phe Leu Gln Pro Gly Gly Lys Met  Val Ala Ala Ala Lys  Ala Ser Val 
        995                 1000                 1005             


Pro Thr  Ile Gln Asp Gln Ala  Ser Ala Met Gln Leu  Ser Gln Cys 
    1010                 1015                 1020             


Ala Lys  Asn Leu Gly Thr Ala  Leu Ala Glu Leu Arg  Thr Ala Ala 
    1025                 1030                 1035             


Gln Lys  Ala Gln Glu Ala Cys  Gly Pro Leu Glu Met  Asp Ser Ala 
    1040                 1045                 1050             


Leu Ser  Val Val Gln Asn Leu  Glu Lys Asp Leu Gln  Glu Val Lys 
    1055                 1060                 1065             


Ala Ala  Ala Arg Asp Gly Lys  Leu Lys Pro Leu Pro  Gly Glu Thr 
    1070                 1075                 1080             


Met Glu  Lys Cys Thr Gln Asp  Leu Gly Asn Ser Thr  Lys Ala Val 
    1085                 1090                 1095             


Ser Ser  Ala Ile Ala Gln Leu  Leu Gly Glu Val Ala  Gln Gly Asn 
    1100                 1105                 1110             


Glu Asn  Tyr Ala Gly Ile Ala  Ala Arg Asp Val Ala  Gly Gly Leu 
    1115                 1120                 1125             


Arg Ser  Leu Ala Gln Ala Ala  Arg Gly Val Ala Ala  Leu Thr Ser 
    1130                 1135                 1140             


Asp Pro  Ala Val Gln Ala Ile  Val Leu Asp Thr Ala  Ser Asp Val 
    1145                 1150                 1155             


Leu Asp  Lys Ala Ser Ser Leu  Ile Glu Glu Ala Lys  Lys Ala Ala 
    1160                 1165                 1170             


Gly His  Pro Gly Asp Pro Glu  Ser Gln Gln Arg Leu  Ala Gln Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Thr Gln Ala  Leu Asn Arg Cys Val  Ser Cys Leu 
    1190                 1195                 1200             


Pro Gly  Gln Arg Asp Val Asp  Asn Ala Leu Arg Ala  Val Gly Asp 
    1205                 1210                 1215             


Ala Ser  Lys Arg Leu Leu Ser  Asp Ser Leu Pro Pro  Ser Thr Gly 
    1220                 1225                 1230             


Thr Phe  Gln Glu Ala Gln Ser  Arg Leu Asn Glu Ala  Ala Ala Gly 
    1235                 1240                 1245             


Leu Asn  Gln Ala Ala Thr Glu  Leu Val Gln Ala Ser  Arg Gly Thr 
    1250                 1255                 1260             


Pro Gln  Asp Leu Ala Arg Ala  Ser Gly Arg Phe Gly  Gln Asp Phe 
    1265                 1270                 1275             


Ser Thr  Phe Leu Glu Ala Gly  Val Glu Met Ala Gly  Gln Ala Pro 
    1280                 1285                 1290             


Ser Gln  Glu Asp Arg Ala Gln  Val Val Ser Asn Leu  Lys Gly Ile 
    1295                 1300                 1305             


Ser Met  Ser Ser Ser Lys Leu  Leu Leu Ala Ala Lys  Ala Leu Ser 
    1310                 1315                 1320             


Thr Asp  Pro Ala Ala Pro Asn  Leu Lys Ser Gln Leu  Ala Ala Ala 
    1325                 1330                 1335             


Ala Arg  Ala Val Thr Asp Ser  Ile Asn Gln Leu Ile  Thr Met Cys 
    1340                 1345                 1350             


Thr Gln  Gln Ala Pro Gly Gln  Lys Glu Cys Asp Asn  Ala Leu Arg 
    1355                 1360                 1365             


Glu Leu  Glu Thr Val Arg Glu  Leu Leu Glu Asn Pro  Val Gln Pro 
    1370                 1375                 1380             


Ile Asn  Asp Met Ser Tyr Phe  Gly Cys Leu Asp Ser  Val Met Glu 
    1385                 1390                 1395             


Asn Ser  Lys Val Leu Gly Glu  Ala Met Thr Gly Ile  Ser Gln Asn 
    1400                 1405                 1410             


Ala Lys  Asn Gly Asn Leu Pro  Glu Phe Gly Asp Ala  Ile Ser Thr 
    1415                 1420                 1425             


Ala Ser  Lys Ala Leu Cys Gly  Phe Thr Glu Ala Ala  Ala Gln Ala 
    1430                 1435                 1440             


Ala Tyr  Leu Val Gly Val Ser  Asp Pro Asn Ser Gln  Ala Gly Gln 
    1445                 1450                 1455             


Gln Gly  Leu Val Glu Pro Thr  Gln Phe Ala Arg Ala  Asn Gln Ala 
    1460                 1465                 1470             


Ile Gln  Met Ala Cys Gln Ser  Leu Gly Glu Pro Gly  Cys Thr Gln 
    1475                 1480                 1485             


Ala Gln  Val Leu Ser Ala Ala  Thr Ile Val Ala Lys  His Thr Ser 
    1490                 1495                 1500             


Ala Leu  Cys Asn Ser Cys Arg  Leu Ala Ser Ala Arg  Thr Thr Asn 
    1505                 1510                 1515             


Pro Thr  Ala Lys Arg Gln Phe  Val Gln Ser Ala Lys  Glu Val Ala 
    1520                 1525                 1530             


Asn Ser  Thr Ala Asn Leu Val  Lys Thr Ile Lys Ala  Leu Asp Gly 
    1535                 1540                 1545             


Ala Phe  Thr Glu Glu Asn Arg  Ala Gln Cys Arg Ala  Ala Thr Ala 
    1550                 1555                 1560             


Pro Leu  Leu Glu Ala Val Asp  Asn Leu Ser Ala Phe  Ala Ser Asn 
    1565                 1570                 1575             


Pro Glu  Phe Ser Ser Ile Pro  Ala Gln Ile Ser Pro  Glu Gly Arg 
    1580                 1585                 1590             


Ala Ala  Met Glu Pro Ile Val  Ile Ser Ala Lys Thr  Met Leu Glu 
    1595                 1600                 1605             


Ser Ala  Gly Gly Leu Ile Gln  Thr Ala Arg Ala Leu  Ala Val Asn 
    1610                 1615                 1620             


Pro Arg  Asp Pro Pro Ser Trp  Ser Val Leu Ala Gly  His Ser Arg 
    1625                 1630                 1635             


Thr Val  Ser Asp Ser Ile Lys  Lys Leu Ile Thr Ser  Met Arg Asp 
    1640                 1645                 1650             


Lys Ala  Pro Gly Gln Leu Glu  Cys Glu Thr Ala Ile  Ala Ala Leu 
    1655                 1660                 1665             


Asn Ser  Cys Leu Arg Asp Leu  Asp Gln Ala Ser Leu  Ala Ala Val 
    1670                 1675                 1680             


Ser Gln  Gln Leu Ala Pro Leu  Gln Glu Ile Ser His  Leu Ile Glu 
    1685                 1690                 1695             


Pro Leu  Ala Asn Ala Ala Arg  Ala Glu Ala Ser Gln  Leu Gly His 
    1700                 1705                 1710             


Lys Val  Ser Gln Met Ala Gln  Tyr Phe Glu Pro Leu  Thr Leu Ala 
    1715                 1720                 1725             


Ala Val  Gly Ala Ala Ser Lys  Thr Leu Ser His Pro  Gln Gln Met 
    1730                 1735                 1740             


Ala Leu  Leu Asp Gln Thr Lys  Thr Leu Ala Glu Ser  Ala Leu Gln 
    1745                 1750                 1755             


Leu Leu  Tyr Thr Ala Lys Glu  Ala Gly Gly Asn Pro  Lys Leu Asp 
    1760                 1765                 1770             


Glu Gly  Pro Met Gly Glu Pro  Glu Gly Ser Phe Val  Asp Tyr Gln 
    1775                 1780                 1785             


Thr Thr  Met Val Arg Thr Ala  Lys Ala Ile Ala Val  Thr Val Gln 
    1790                 1795                 1800             


Glu Met  Ile Gly Ser His Ile  Lys His Arg Val Gln  Glu Leu Gly 
    1805                 1810                 1815             


His Gly  Cys Ala Ala Leu Val  Thr Lys Ala Gly Ala  Leu Gln Cys 
    1820                 1825                 1830             


Ser Pro  Ser Asp Ala Tyr Thr  Lys Lys Glu Leu Ile  Glu Cys Ala 
    1835                 1840                 1845             


Arg Arg  Val Ser Glu Lys Val  Ser His Val Leu Ala  Ala Leu Gln 
    1850                 1855                 1860             


Ala Gly  Asn Arg Gly Thr Gln  Ala Cys Ile Thr Ala  Ala Ser Ala 
    1865                 1870                 1875             


Val Ser  Gly Ile Ile Ala Asp  Leu Asp Thr Thr Ile  Met Phe Ala 
    1880                 1885                 1890             


Thr Ala  Gly Thr Leu Asn Arg  Glu Gly Thr Glu Thr  Phe Ala Asp 
    1895                 1900                 1905             


His Arg  Glu Gly Ile Leu Lys  Thr Ala Lys Val Leu  Val Glu Asp 
    1910                 1915                 1920             


Thr Lys  Val Leu Val Gln Asn  Ala Ala Gly Ser Gln  Glu Lys Leu 
    1925                 1930                 1935             


Ala Gln  Ala Ala Gln Ser Ser  Val Ala Thr Ile Thr  Arg Leu Ala 
    1940                 1945                 1950             


Asp Val  Val Lys Leu Gly Ala  Ala Ser Leu Gly Ala  Glu Asp Pro 
    1955                 1960                 1965             


Glu Thr  Gln Val Val Leu Ile  Asn Ala Val Lys Asp  Val Ala Lys 
    1970                 1975                 1980             


Ala Leu  Gly Asp Leu Ile Ser  Ala Thr Lys Ala Ala  Ala Gly Lys 
    1985                 1990                 1995             


Val Gly  Asp Asp Pro Ala Val  Trp Gln Leu Lys Asn  Ser Ala Lys 
    2000                 2005                 2010             


Val Met  Val Thr Asn Val Thr  Ser Leu Leu Lys Thr  Val Lys Ala 
    2015                 2020                 2025             


Val Glu  Asp Glu Ala Thr Lys  Gly Thr Arg Ala Leu  Glu Ala Thr 
    2030                 2035                 2040             


Thr Glu  His Ile Arg Gln Glu  Leu Ala Pro Pro Ala  Lys Thr Ser 
    2045                 2050                 2055             


Thr Pro  Glu Asp Phe Ile Arg  Met Thr Lys Gly Ile  Thr Met Ala 
    2060                 2065                 2070             


Thr Ala  Lys Ala Val Ala Ala  Gly Asn Ser Cys Arg  Gln Glu Asp 
    2075                 2080                 2085             


Val Ile  Ala Thr Ala Asn Leu  Ser Arg Arg Ala Ile  Ala Asp Met 
    2090                 2095                 2100             


Leu Arg  Ala Cys Lys Glu Ala  Ala Tyr His Pro Glu  Val Ala Pro 
    2105                 2110                 2115             


Asp Val  Arg Leu Arg Ala Leu  His Tyr Gly Arg Glu  Cys Ala Asn 
    2120                 2125                 2130             


Gly Tyr  Leu Glu Leu Leu Asp  His Val Leu Leu Thr  Leu Gln Lys 
    2135                 2140                 2145             


Pro Ser  Pro Glu Leu Lys Gln  Gln Leu Thr Gly His  Ser Lys Arg 
    2150                 2155                 2160             


Val Ala  Gly Ser Val Thr Glu  Leu Ile Gln Ala Ala  Glu Ala Met 
    2165                 2170                 2175             


Lys Gly  Thr Glu Trp Val Asp  Pro Glu Asp Pro Thr  Val Ile Ala 
    2180                 2185                 2190             


Glu Asn  Glu Leu Leu Gly Ala  Ala Ala Ala Ile Glu  Ala Ala Ala 
    2195                 2200                 2205             


Lys Lys  Leu Glu Gln Leu Lys  Pro Arg Ala Lys Pro  Lys Glu Ala 
    2210                 2215                 2220             


Asp Glu  Ser Leu Asn Phe Glu  Glu Gln Ile Leu Glu  Ala Ala Lys 
    2225                 2230                 2235             


Ser Ile  Ala Ala Ala Thr Ser  Ala Leu Val Lys Ala  Ala Ser Ala 
    2240                 2245                 2250             


Ala Gln  Arg Glu Leu Val Ala  Gln Gly Lys Val Gly  Ala Ile Pro 
    2255                 2260                 2265             


Ala Asn  Ala Leu Asp Asp Gly  Gln Trp Ser Gln Gly  Leu Ile Ser 
    2270                 2275                 2280             


Ala Ala  Arg Met Val Ala Ala  Ala Thr Asn Asn Leu  Cys Glu Ala 
    2285                 2290                 2295             


Ala Asn  Ala Ala Val Gln Gly  His Ala Ser Gln Glu  Lys Leu Ile 
    2300                 2305                 2310             


Ser Ser  Ala Lys Gln Val Ala  Ala Ser Thr Ala Gln  Leu Leu Val 
    2315                 2320                 2325             


Ala Cys  Lys Val Lys Ala Asp  Gln Asp Ser Glu Ala  Met Lys Arg 
    2330                 2335                 2340             


Leu Gln  Ala Ala Gly Asn Ala  Val Lys Arg Ala Ser  Asp Asn Leu 
    2345                 2350                 2355             


Val Lys  Ala Ala Gln Lys Ala  Ala Ala Phe Glu Glu  Gln Glu Asn 
    2360                 2365                 2370             


Glu Thr  Val Val Val Lys Glu  Lys Met Val Gly Gly  Ile Ala Gln 
    2375                 2380                 2385             


Ile Ile  Ala Ala Gln Glu Glu  Met Leu Arg Lys Glu  Arg Glu Leu 
    2390                 2395                 2400             


Glu Glu  Ala Arg Lys Lys Leu  Ala Gln Ile Arg Gln  Gln Gln Tyr 
    2405                 2410                 2415             


Lys Phe  Leu Pro Ser Glu Leu  Arg Asp Glu His 
    2420                 2425                 


<210>  7
<211>  351
<212>  PRT
<213>  Homo sapien

<400>  7

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg Asp 
145                 150                 155                 160 


Leu Thr Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe 
                165                 170                 175     


Thr Thr Thr Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu 
            180                 185                 190         


Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala Thr Ala Ala Ser 
        195                 200                 205             


Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala Leu Phe Gln Pro 
225                 230                 235                 240 


Ser Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu Thr Thr Phe Asn 
                245                 250                 255     


Ser Ile Met Lys Cys Asp Val Asp Ile Arg Lys Asp Leu Tyr Ala Asn 
            260                 265                 270         


Thr Val Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg 
        275                 280                 285             


Met Gln Lys Glu Ile Thr Ala Leu Ala Pro Ser Thr Met Lys Ile Lys 
    290                 295                 300                 


Ile Ile Ala Pro Pro Glu Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser 
305                 310                 315                 320 


Ile Leu Ala Ser Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys Gln 
                325                 330                 335     


Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg Lys Cys Phe 
            340                 345                 350     


<210>  8
<211>  467
<212>  PRT
<213>  Homo sapien

<400>  8

Met Pro Lys Asp Ser Ala Phe Pro Arg Ala Pro Ala Ala Gly Arg Glu 
1               5                   10                  15      


Asn Gly Gly Gly Gly Asp Gly Arg Ala Leu Leu Lys Gln Gln Leu Trp 
            20                  25                  30          


Ser Phe Pro Gln Gly Arg Gly Arg Ser Gly Ser Leu Thr Arg Thr Gly 
        35                  40                  45              


Phe Arg Val Thr Ala Ser Tyr Cys Ser Cys Cys Cys Ser Thr Arg Gln 
    50                  55                  60                  


Ser Gly Ser Ala Ser Ser Ser Cys Ala Ser Phe Ser Gly Ser Thr Ser 
65                  70                  75                  80  


Ser Trp Ser Ala Ala Arg Cys Gln Thr Ala Ser Phe Ala Gly Ser Asp 
                85                  90                  95      


Ala Gly Val Arg Gly Val Ser Glu Leu Gly Leu Ala Arg Gly His Thr 
            100                 105                 110         


Val Thr Thr Ser Cys Val Pro Arg Phe Val Val Arg Thr Met Cys Ala 
        115                 120                 125             


Val Leu Gly Leu Val Ala Arg Gln Glu Asp Ser Gly Leu Arg Asp His 
    130                 135                 140                 


Ser Val Arg Val Leu Ile Ser Asn His Val Thr Pro Phe Asp His Asn 
145                 150                 155                 160 


Ile Val Asn Leu Leu Thr Thr Cys Ser Thr Pro Leu Leu Asn Ser Pro 
                165                 170                 175     


Pro Ser Phe Val Cys Trp Ser Arg Gly Phe Met Glu Met Asn Gly Arg 
            180                 185                 190         


Gly Glu Leu Val Glu Ser Leu Lys Arg Phe Cys Ala Ser Thr Arg Leu 
        195                 200                 205             


Pro Pro Thr Pro Leu Leu Leu Phe Pro Glu Glu Glu Ala Thr Asn Gly 
    210                 215                 220                 


Arg Glu Gly Leu Leu Arg Phe Ser Ser Trp Pro Phe Ser Ile Gln Asp 
225                 230                 235                 240 


Val Val Gln Pro Leu Thr Leu Gln Val Gln Arg Pro Leu Val Ser Val 
                245                 250                 255     


Thr Val Ser Asp Ala Ser Trp Val Ser Glu Leu Leu Trp Ser Leu Phe 
            260                 265                 270         


Val Pro Phe Thr Val Tyr Gln Val Arg Trp Leu Arg Pro Val His Arg 
        275                 280                 285             


Gln Leu Gly Glu Ala Asn Glu Glu Phe Ala Leu Arg Val Gln Gln Leu 
    290                 295                 300                 


Val Ala Lys Glu Leu Gly Gln Thr Gly Thr Arg Leu Thr Pro Ala Asp 
305                 310                 315                 320 


Lys Ala Glu His Met Lys Arg Gln Arg His Pro Arg Leu Arg Pro Gln 
                325                 330                 335     


Ser Ala Gln Ser Ser Phe Pro Pro Ser Pro Gly Pro Ser Pro Asp Val 
            340                 345                 350         


Gln Leu Ala Thr Leu Ala Gln Arg Val Lys Glu Val Leu Pro His Val 
        355                 360                 365             


Pro Leu Gly Val Ile Gln Arg Asp Leu Ala Lys Thr Gly Cys Val Asp 
    370                 375                 380                 


Leu Thr Ile Thr Asn Leu Leu Glu Gly Ala Val Ala Phe Met Pro Glu 
385                 390                 395                 400 


Asp Ile Thr Lys Gly Thr Gln Ser Leu Leu Thr Ala Ser Ala Ser Lys 
                405                 410                 415     


Phe Pro Ser Ser Gly Pro Val Thr Pro Gln Pro Thr Ala Leu Thr Phe 
            420                 425                 430         


Ala Lys Ser Ser Trp Ala Arg Gln Glu Ser Leu Gln Glu Arg Lys Gln 
        435                 440                 445             


Ala Leu Tyr Glu Tyr Ala Arg Arg Arg Phe Thr Glu Arg Arg Ala Gln 
    450                 455                 460                 


Glu Ala Asp 
465         


<210>  9
<211>  1301
<212>  PRT
<213>  Homo sapien

<400>  9

Met Glu Met Val Gly Phe Leu Pro Lys Thr Arg Arg Gln Ile Phe Ser 
1               5                   10                  15      


Leu Leu Ser Ala Ile Leu His Leu Gly Asn Ile Cys Tyr Lys Lys Lys 
            20                  25                  30          


Thr Tyr Arg Asp Asp Ser Ile Asp Ile Cys Asn Pro Glu Val Leu Pro 
        35                  40                  45              


Ile Val Ser Glu Leu Leu Glu Val Lys Glu Glu Met Leu Phe Glu Ala 
    50                  55                  60                  


Leu Val Thr Arg Lys Thr Val Thr Val Gly Glu Lys Leu Ile Leu Pro 
65                  70                  75                  80  


Tyr Lys Leu Ala Glu Ala Val Thr Val Arg Asn Ser Met Ala Lys Ser 
                85                  90                  95      


Leu Tyr Ser Ala Leu Phe Asp Trp Ile Val Phe Arg Ile Asn His Ala 
            100                 105                 110         


Leu Leu Asn Ser Lys Asp Leu Glu His Asn Thr Lys Thr Leu Ser Ile 
        115                 120                 125             


Gly Val Leu Asp Ile Phe Gly Phe Glu Asp Tyr Glu Asn Asn Ser Phe 
    130                 135                 140                 


Glu Gln Phe Cys Ile Asn Phe Ala Asn Glu Arg Leu Gln His Tyr Phe 
145                 150                 155                 160 


Asn Gln His Ile Phe Lys Leu Glu Gln Glu Glu Tyr Arg Thr Glu Gly 
                165                 170                 175     


Ile Ser Trp His Asn Ile Asp Tyr Ile Asp Asn Thr Cys Cys Ile Asn 
            180                 185                 190         


Leu Ile Ser Lys Lys Pro Thr Gly Leu Leu His Leu Leu Asp Glu Glu 
        195                 200                 205             


Ser Asn Phe Pro Gln Ala Thr Asn Gln Thr Leu Leu Asp Lys Phe Lys 
    210                 215                 220                 


His Gln His Glu Asp Asn Ser Tyr Ile Glu Phe Pro Ala Val Met Glu 
225                 230                 235                 240 


Pro Ala Phe Ile Ile Lys His Tyr Ala Gly Lys Val Lys Tyr Gly Val 
                245                 250                 255     


Lys Asp Phe Arg Glu Lys Asn Thr Asp His Met Arg Pro Asp Ile Val 
            260                 265                 270         


Ala Leu Leu Arg Ser Ser Lys Asn Ala Phe Ile Ser Gly Met Ile Gly 
        275                 280                 285             


Ile Asp Pro Val Ala Val Phe Arg Trp Ala Ile Leu Arg Ala Phe Phe 
    290                 295                 300                 


Arg Ala Met Val Ala Phe Arg Glu Ala Gly Lys Arg Asn Ile His Arg 
305                 310                 315                 320 


Lys Thr Gly His Asp Asp Thr Ala Pro Cys Ala Ile Leu Lys Ser Met 
                325                 330                 335     


Asp Ser Phe Ser Phe Leu Gln His Pro Val His Gln Arg Ser Leu Glu 
            340                 345                 350         


Ile Leu Gln Arg Cys Lys Glu Glu Lys Tyr Ser Lys Ala Thr Asn Pro 
        355                 360                 365             


Asp Lys Leu Leu Ser His Ile His Leu Glu Met Glu Thr Arg Ser Ile 
    370                 375                 380                 


Leu His Gln Gly Ile Thr Arg Lys Asn Pro Arg Thr Pro Leu Ser Asp 
385                 390                 395                 400 


Leu Gln Gly Met Asn Ala Leu Asn Glu Lys Asn Gln His Asp Thr Phe 
                405                 410                 415     


Asp Ile Ala Trp Asn Gly Arg Thr Gly Ile Arg Gln Ser Arg Leu Ser 
            420                 425                 430         


Ser Gly Thr Ser Leu Leu Asp Lys Asp Gly Ile Phe Ala Asn Ser Thr 
        435                 440                 445             


Ser Ser Lys Leu Leu Glu Arg Ala His Gly Ile Leu Thr Arg Asn Lys 
    450                 455                 460                 


Asn Phe Lys Ser Lys Pro Ala Leu Pro Lys His Leu Leu Glu Val Asn 
465                 470                 475                 480 


Ser Leu Lys His Leu Thr Arg Leu Thr Leu Gln Asp Arg Ile Thr Lys 
                485                 490                 495     


Ser Leu Leu His Leu His Lys Lys Lys Lys Pro Pro Ser Ile Ser Ala 
            500                 505                 510         


Gln Phe Gln Ala Ser Leu Ser Lys Leu Met Glu Thr Leu Gly Gln Ala 
        515                 520                 525             


Glu Pro Tyr Phe Val Lys Cys Ile Arg Ser Asn Ala Glu Lys Leu Pro 
    530                 535                 540                 


Leu Arg Phe Ser Asp Val Leu Val Leu Arg Gln Leu Arg Tyr Thr Gly 
545                 550                 555                 560 


Met Leu Glu Thr Val Arg Ile Arg Gln Ser Gly Tyr Ser Ser Lys Tyr 
                565                 570                 575     


Ser Phe Gln Asp Phe Val Ser His Phe His Val Leu Leu Pro Arg Asn 
            580                 585                 590         


Ile Ile Pro Ser Lys Phe Asn Ile Gln Asp Phe Phe Arg Lys Ile Asn 
        595                 600                 605             


Leu Asn Pro Asp Asn Tyr Gln Val Gly Lys Thr Met Val Phe Leu Lys 
    610                 615                 620                 


Glu Gln Glu Arg Gln His Leu Gln Asp Leu Leu His Gln Glu Val Leu 
625                 630                 635                 640 


Arg Arg Ile Ile Leu Leu Gln Arg Trp Phe Arg Val Leu Leu Cys Arg 
                645                 650                 655     


Gln His Phe Leu His Leu Arg Gln Ala Ser Val Ile Ile Gln Arg Phe 
            660                 665                 670         


Trp Arg Asn Tyr Leu Asn Gln Lys Gln Val Arg Asp Ala Ala Val Gln 
        675                 680                 685             


Lys Asp Ala Phe Val Met Ala Ser Ala Ala Ala Leu Leu Gln Ala Ser 
    690                 695                 700                 


Trp Arg Ala His Leu Glu Arg Gln Arg Tyr Leu Glu Leu Arg Ala Ala 
705                 710                 715                 720 


Ala Ile Val Ile Gln Gln Lys Trp Arg Asp Tyr Tyr Arg Arg Arg His 
                725                 730                 735     


Met Ala Ala Ile Cys Ile Gln Ala Arg Trp Lys Ala Tyr Arg Glu Ser 
            740                 745                 750         


Lys Arg Tyr Gln Glu Gln Arg Lys Lys Ile Ile Leu Leu Gln Ser Thr 
        755                 760                 765             


Cys Arg Gly Phe Arg Ala Arg Gln Arg Phe Lys Ala Leu Lys Glu Gln 
    770                 775                 780                 


Arg Leu Arg Glu Thr Lys Pro Glu Val Gly Leu Val Asn Ile Lys Gly 
785                 790                 795                 800 


Tyr Gly Ser Leu Glu Ile Gln Gly Ser Asp Pro Ser Gly Trp Glu Asp 
                805                 810                 815     


Cys Ser Phe Asp Asn Arg Ile Lys Ala Ile Glu Glu Cys Lys Ser Val 
            820                 825                 830         


Ile Glu Ser Asn Arg Ile Ser Arg Glu Ser Ser Val Asp Cys Leu Lys 
        835                 840                 845             


Glu Ser Pro Asn Lys Gln Gln Glu Arg Ala Gln Ser Gln Ser Gly Val 
    850                 855                 860                 


Asp Leu Gln Glu Asp Val Leu Val Arg Glu Arg Pro Arg Ser Leu Glu 
865                 870                 875                 880 


Asp Leu His Gln Lys Lys Val Gly Arg Ala Lys Arg Glu Ser Arg Arg 
                885                 890                 895     


Met Arg Glu Leu Glu Gln Ala Ile Phe Ser Leu Glu Leu Leu Lys Val 
            900                 905                 910         


Arg Ser Leu Gly Gly Ile Ser Pro Ser Glu Asp Arg Arg Trp Ser Thr 
        915                 920                 925             


Glu Leu Val Pro Glu Gly Leu Gln Ser Pro Arg Gly Thr Pro Asp Ser 
    930                 935                 940                 


Glu Ser Ser Gln Gly Ser Leu Glu Leu Leu Ser Tyr Glu Glu Ser Gln 
945                 950                 955                 960 


Lys Ser Lys Leu Glu Ser Val Ile Ser Asp Glu Gly Asp Leu Gln Phe 
                965                 970                 975     


Pro Ser Pro Lys Ile Ser Ser Ser Pro Lys Phe Asp Ser Arg Asp Asn 
            980                 985                 990         


Ala Leu Ser Ala Ser Asn Glu Thr  Ser Ser Ala Glu His  Leu Lys Asp 
        995                 1000                 1005             


Gly Thr  Met Lys Glu Met Val  Val Cys Ser Ser Glu  Ser Ile Thr 
    1010                 1015                 1020             


Cys Lys  Pro Gln Leu Lys Asp  Ser Phe Ile Ser Asn  Ser Leu Pro 
    1025                 1030                 1035             


Thr Phe  Phe Tyr Ile Pro Gln  Gln Asp Pro Leu Lys  Thr Asn Ser 
    1040                 1045                 1050             


Gln Leu  Asp Thr Ser Ile Gln  Arg Asn Lys Leu Leu  Glu Asn Glu 
    1055                 1060                 1065             


Asp Thr  Ala Gly Glu Ala Leu  Thr Leu Asp Ile Asn  Arg Glu Thr 
    1070                 1075                 1080             


Arg Arg  Tyr His Cys Ser Gly  Lys Asp Gln Ile Val  Pro Ser Leu 
    1085                 1090                 1095             


Asn Thr  Glu Ser Ser Asn Pro  Val Leu Lys Lys Leu  Glu Lys Leu 
    1100                 1105                 1110             


Asn Thr  Glu Lys Glu Glu Arg  Gln Lys Gln Leu Gln  Gln Gln Asn 
    1115                 1120                 1125             


Glu Lys  Glu Met Met Glu Gln  Ile Arg Gln Gln Thr  Asp Ile Leu 
    1130                 1135                 1140             


Glu Lys  Glu Arg Lys Ala Phe  Lys Thr Ile Glu Lys  Pro Arg Ile 
    1145                 1150                 1155             


Gly Glu  Cys Leu Val Ala Pro  Ser Ser Tyr Gln Ser  Lys Gln Arg 
    1160                 1165                 1170             


Val Glu  Arg Pro Ser Ser Leu  Leu Ser Leu Asn Thr  Ser Asn Lys 
    1175                 1180                 1185             


Gly Glu  Leu Asn Val Leu Gly  Ser Leu Ser Leu Lys  Asp Ala Ala 
    1190                 1195                 1200             


Leu Ala  Gln Lys Asp Ser Ser  Ser Ala His Leu Pro  Pro Lys Asp 
    1205                 1210                 1215             


Arg Pro  Val Thr Val Phe Phe  Glu Arg Lys Gly Ser  Pro Cys Gln 
    1220                 1225                 1230             


Ser Ser  Thr Val Lys Glu Leu  Ser Lys Thr Asp Arg  Met Gly Thr 
    1235                 1240                 1245             


Gln Leu  Asn Val Ala Cys Lys  Leu Ser Asn Asn Arg  Ile Ser Lys 
    1250                 1255                 1260             


Arg Glu  His Phe Arg Pro Thr  Gln Ser Tyr Ser His  Asn Ser Asp 
    1265                 1270                 1275             


Asp Leu  Ser Arg Glu Gly Asn  Ala Arg Pro Ile Phe  Phe Thr Pro 
    1280                 1285                 1290             


Lys Asp  Asn Met Ser Ile Pro  Leu 
    1295                 1300     


<210>  10
<211>  165
<212>  PRT
<213>  Homo sapien

<400>  10

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  11
<211>  131
<212>  PRT
<213>  Homo sapien

<400>  11

Met Ser Cys Gln Lys Ala Val Leu Glu Leu Asn Ile Gly Ser Gln Leu 
1               5                   10                  15      


Gly Pro Lys Ser Pro Glu Arg Thr Glu Gly Val Thr Ala Phe Glu Asp 
            20                  25                  30          


Tyr Gly Thr Gly Leu Leu Glu Asn Gln Leu Ser Val Gly Asp Phe Val 
        35                  40                  45              


Lys Ile Gln Lys Ala Phe Glu Asp Gly Asp Ile Trp Leu Thr Glu Gln 
    50                  55                  60                  


His Tyr Glu Trp Leu Lys Thr Arg Gln Lys Leu Gly Leu Leu Thr Trp 
65                  70                  75                  80  


Met Lys Cys Arg Ser Cys Ile Cys Glu Arg Ala Met Val Leu Gly Thr 
                85                  90                  95      


Val Pro Thr Ala Lys Glu Asn His Leu Tyr Val Gln Arg Arg Leu His 
            100                 105                 110         


Ala Glu Asp Asp Arg Asp Cys Trp Leu Gly His Glu Gly Arg Ile Trp 
        115                 120                 125             


Gly Ala Leu 
    130     


<210>  12
<211>  644
<212>  PRT
<213>  Homo sapien

<400>  12

Met Ser Arg Gln Phe Ser Ser Arg Ser Gly Tyr Arg Ser Gly Gly Gly 
1               5                   10                  15      


Phe Ser Ser Gly Ser Ala Gly Ile Ile Asn Tyr Gln Arg Arg Thr Thr 
            20                  25                  30          


Ser Ser Ser Thr Arg Arg Ser Gly Gly Gly Gly Gly Arg Phe Ser Ser 
        35                  40                  45              


Cys Gly Gly Gly Gly Gly Ser Phe Gly Ala Gly Gly Gly Phe Gly Ser 
    50                  55                  60                  


Arg Ser Leu Val Asn Leu Gly Gly Ser Lys Ser Ile Ser Ile Ser Val 
65                  70                  75                  80  


Ala Arg Gly Gly Gly Arg Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly 
                85                  90                  95      


Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly 
            100                 105                 110         


Gly Ile Gly Gly Gly Gly Phe Gly Gly Phe Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Tyr Gly Gly Gly Tyr Gly 
    130                 135                 140                 


Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Ile Asn Gln Ser 
145                 150                 155                 160 


Leu Leu Gln Pro Leu Asn Val Glu Ile Asp Pro Glu Ile Gln Lys Val 
                165                 170                 175     


Lys Ser Arg Glu Arg Glu Gln Ile Lys Ser Leu Asn Asn Gln Phe Ala 
            180                 185                 190         


Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu 
        195                 200                 205             


Gln Thr Lys Trp Glu Leu Leu Gln Gln Val Asp Thr Ser Thr Arg Thr 
    210                 215                 220                 


His Asn Leu Glu Pro Tyr Phe Glu Ser Phe Ile Asn Asn Leu Arg Arg 
225                 230                 235                 240 


Arg Val Asp Gln Leu Lys Ser Asp Gln Ser Arg Leu Asp Ser Glu Leu 
                245                 250                 255     


Lys Asn Met Gln Asp Met Val Glu Asp Tyr Arg Asn Lys Tyr Glu Asp 
            260                 265                 270         


Glu Ile Asn Lys Arg Thr Asn Ala Glu Asn Glu Phe Val Thr Ile Lys 
        275                 280                 285             


Lys Asp Val Asp Gly Ala Tyr Met Thr Lys Val Asp Leu Gln Ala Lys 
    290                 295                 300                 


Leu Asp Asn Leu Gln Gln Glu Ile Asp Phe Leu Thr Ala Leu Tyr Gln 
305                 310                 315                 320 


Ala Glu Leu Ser Gln Met Gln Thr Gln Ile Ser Glu Thr Asn Val Ile 
                325                 330                 335     


Leu Ser Met Asp Asn Asn Arg Ser Leu Asp Leu Asp Ser Ile Ile Ala 
            340                 345                 350         


Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Gln Lys Ser Lys Ala Glu 
        355                 360                 365             


Ala Glu Ser Leu Tyr Gln Ser Lys Tyr Glu Glu Leu Gln Ile Thr Ala 
    370                 375                 380                 


Gly Arg His Gly Asp Ser Val Arg Asn Ser Lys Ile Glu Ile Ser Glu 
385                 390                 395                 400 


Leu Asn Arg Val Ile Gln Arg Leu Arg Ser Glu Ile Asp Asn Val Lys 
                405                 410                 415     


Lys Gln Ile Ser Asn Leu Gln Gln Ser Ile Ser Asp Ala Glu Gln Arg 
            420                 425                 430         


Gly Glu Asn Ala Leu Lys Asp Ala Lys Asn Lys Leu Asn Asp Leu Glu 
        435                 440                 445             


Asp Ala Leu Gln Gln Ala Lys Glu Asp Leu Ala Arg Leu Leu Arg Asp 
    450                 455                 460                 


Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp Leu Glu Ile Ala 
465                 470                 475                 480 


Thr Tyr Arg Thr Leu Leu Glu Gly Glu Glu Ser Arg Met Ser Gly Glu 
                485                 490                 495     


Cys Ala Pro Asn Val Ser Val Ser Val Ser Thr Ser His Thr Thr Ile 
            500                 505                 510         


Ser Gly Gly Gly Ser Arg Gly Gly Gly Gly Gly Gly Tyr Gly Ser Gly 
        515                 520                 525             


Gly Ser Ser Tyr Gly Ser Gly Gly Gly Ser Tyr Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Gly Gly Gly Arg Gly Ser Tyr Gly Ser Gly Gly Ser Ser Tyr Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Ser Tyr Gly Ser Gly Gly Gly Gly Gly Gly His Gly 
                565                 570                 575     


Ser Tyr Gly Ser Gly Ser Ser Ser Gly Gly Tyr Arg Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Gly Gly Ser Ser Gly Gly Arg Gly Ser Gly Gly Gly Ser 
        595                 600                 605             


Ser Gly Gly Ser Ile Gly Gly Arg Gly Ser Ser Ser Gly Gly Val Lys 
    610                 615                 620                 


Ser Ser Gly Gly Ser Ser Ser Val Lys Phe Val Ser Thr Thr Tyr Ser 
625                 630                 635                 640 


Gly Val Thr Arg 
                


<210>  13
<211>  53
<212>  PRT
<213>  Homo sapien

<400>  13

Ser Phe Thr Gly Leu Gly Trp Glu Ile Arg Met His Cys Glu Leu Phe 
1               5                   10                  15      


Phe Asn Ser Phe Gln Gly Phe Phe Val Ser Ile Ile Tyr Cys Tyr Cys 
            20                  25                  30          


Asn Gly Glu Ile Gly Arg Leu Leu Cys Met Asp Lys Ile Pro Ala Thr 
        35                  40                  45              


Ala Ser Leu Thr Pro 
    50              


<210>  14
<211>  201
<212>  PRT
<213>  Homo sapien

<400>  14

Met Glu Tyr Leu Ile Gly Ile Gln Gly Pro Asp Tyr Val Leu Val Ala 
1               5                   10                  15      


Ser Asp Arg Val Ala Ala Ser Asn Ile Val Gln Met Lys Asp Asp His 
            20                  25                  30          


Asp Lys Met Phe Lys Met Ser Glu Lys Ile Leu Leu Leu Cys Val Gly 
        35                  40                  45              


Glu Ala Gly Asp Thr Val Gln Phe Ala Glu Tyr Ile Gln Lys Asn Val 
    50                  55                  60                  


Gln Leu Tyr Lys Met Arg Asn Gly Tyr Glu Leu Ser Pro Thr Ala Ala 
65                  70                  75                  80  


Ala Asn Phe Thr Arg Arg Asn Leu Ala Asp Cys Leu Arg Ser Arg Thr 
                85                  90                  95      


Pro Tyr His Val Asn Leu Leu Leu Ala Gly Tyr Asp Glu His Glu Gly 
            100                 105                 110         


Pro Ala Leu Tyr Tyr Met Asp Tyr Leu Ala Ala Leu Ala Lys Ala Pro 
        115                 120                 125             


Phe Ala Ala His Gly Tyr Gly Ala Phe Leu Thr Leu Ser Ile Leu Asp 
    130                 135                 140                 


Arg Tyr Tyr Thr Pro Thr Ile Ser Arg Glu Arg Ala Val Glu Leu Leu 
145                 150                 155                 160 


Arg Lys Cys Leu Glu Glu Leu Gln Lys Arg Phe Ile Leu Asn Leu Pro 
                165                 170                 175     


Thr Phe Ser Val Arg Ile Ile Asp Lys Asn Gly Ile His Asp Leu Asp 
            180                 185                 190         


Asn Ile Ser Phe Pro Lys Gln Gly Ser 
        195                 200     


<210>  15
<211>  175
<212>  PRT
<213>  Homo sapien

<400>  15

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
        115                 120                 125             


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
145                 150                 155                 160 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 175 


<210>  16
<211>  95
<212>  PRT
<213>  Homo sapien

<400>  16

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Gly Leu Ser Asp Val Gly Thr 
                85                  90                  95  


<210>  17
<211>  125
<212>  PRT
<213>  Homo sapien

<400>  17

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Asp Ser Leu Leu 
        115                 120                 125 


<210>  18
<211>  584
<212>  PRT
<213>  Homo sapien

<400>  18

Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser 
            20                  25                  30          


Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser 
        35                  40                  45              


Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly 
    50                  55                  60                  


Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Ser Phe Arg Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly 
                85                  90                  95      


Ser Tyr Gly Gly Ile Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe 
            100                 105                 110         


Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly 
    130                 135                 140                 


Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr 
145                 150                 155                 160 


Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly 
                165                 170                 175     


Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu 
            180                 185                 190         


Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn 
        195                 200                 205             


Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile 
    210                 215                 220                 


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg 
                245                 250                 255     


Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln 
            260                 265                 270         


Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu 
        275                 280                 285             


Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val 
    290                 295                 300                 


Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn 
305                 310                 315                 320 


Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala 
                325                 330                 335     


Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp 
            340                 345                 350         


Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu 
        355                 360                 365             


Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala 
    370                 375                 380                 


Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr 
385                 390                 395                 400 


Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu 
                405                 410                 415     


Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr 
            420                 425                 430         


Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr 
        435                 440                 445             


Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg 
    450                 455                 460                 


Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gly Gly His Gly Gly Gly His Gly Gly Ser Ser Gly 
                485                 490                 495     


Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
            500                 505                 510         


Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly 
        515                 520                 525             


Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly Tyr Gly Gly 
    530                 535                 540                 


Gly Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly 
545                 550                 555                 560 


Ser Ser Ser Gly Gly His Lys Ser Ser Ser Ser Gly Ser Val Gly Glu 
                565                 570                 575     


Ser Ser Ser Lys Gly Pro Arg Tyr 
            580                 


<210>  19
<211>  156
<212>  PRT
<213>  Homo sapien

<400>  19

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Phe 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr 
        115                 120                 125             


Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr 
    130                 135                 140                 


Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
145                 150                 155     


<210>  20
<211>  93
<212>  PRT
<213>  Homo sapien

<400>  20

Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 
1               5                   10                  15      


Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 
            20                  25                  30          


Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 
        35                  40                  45              


Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 
    50                  55                  60                  


Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu Leu Phe Val Glu Ala 
65                  70                  75                  80  


Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys Leu Ala 
                85                  90              


<210>  21
<211>  184
<212>  PRT
<213>  Homo sapien

<400>  21

Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Ala 
        35                  40                  45              


Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
    50                  55                  60                  


Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu 
65                  70                  75                  80  


Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu 
                85                  90                  95      


Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys 
        115                 120                 125             


Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Asn Asn Cys Ala Phe Leu 
    130                 135                 140                 


Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
145                 150                 155                 160 


Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Pro Gly Lys Ala Arg 
                165                 170                 175     


Lys Lys Ser Ser Cys Gln Leu Leu 
            180                 


<210>  22
<211>  375
<212>  PRT
<213>  Homo sapien

<400>  22

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  23
<211>  1075
<212>  PRT
<213>  Homo sapien

<400>  23

Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys 
1               5                   10                  15      


Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe 
            20                  25                  30          


Pro Cys Cys Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp 
    50                  55                  60                  


Cys Arg His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val 
65                  70                  75                  80  


Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Ser Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Val Asn Lys Gln Asp Lys Gln Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met 
    210                 215                 220                 


Leu Leu Glu His Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn 
225                 230                 235                 240 


Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys 
                245                 250                 255     


Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly 
            260                 265                 270         


Leu Thr Pro Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val 
        275                 280                 285             


Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr 
    290                 295                 300                 


Gly Arg Thr Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile 
305                 310                 315                 320 


Val Ser Leu Leu Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu 
                325                 330                 335     


Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val 
            340                 345                 350         


Ile Cys Gln Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile 
        355                 360                 365             


Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp Leu Lys Leu Thr Ser Glu 
    370                 375                 380                 


Glu Glu Ser Gln Arg Phe Lys Gly Ser Glu Asn Ser Gln Pro Glu Lys 
385                 390                 395                 400 


Met Ser Gln Glu Pro Glu Ile Asn Lys Asp Gly Asp Arg Glu Val Glu 
                405                 410                 415     


Glu Glu Met Lys Lys His Glu Ser Asn Asn Val Gly Leu Leu Glu Asn 
            420                 425                 430         


Leu Thr Asn Gly Val Thr Ala Gly Asn Gly Asp Asn Gly Leu Ile Pro 
        435                 440                 445             


Gln Arg Lys Ser Arg Thr Pro Glu Asn Gln Gln Phe Pro Asp Asn Glu 
    450                 455                 460                 


Ser Glu Glu Tyr His Arg Ile Cys Glu Leu Leu Ser Asp Tyr Lys Glu 
465                 470                 475                 480 


Lys Gln Met Pro Lys Tyr Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp 
                485                 490                 495     


Leu Lys Leu Thr Ser Glu Glu Glu Ser Gln Arg Leu Lys Gly Ser Glu 
            500                 505                 510         


Asn Gly Gln Pro Glu Lys Arg Ser Gln Glu Pro Glu Ile Asn Lys Asp 
        515                 520                 525             


Gly Asp Arg Glu Leu Glu Asn Phe Met Ala Ile Glu Glu Met Lys Lys 
    530                 535                 540                 


His Arg Ser Thr His Val Gly Phe Pro Glu Asn Leu Thr Asn Gly Ala 
545                 550                 555                 560 


Thr Ala Gly Asn Gly Asp Asp Gly Leu Ile Pro Pro Arg Lys Ser Arg 
                565                 570                 575     


Thr Pro Glu Ser Gln Gln Phe Pro Asp Thr Glu Asn Glu Glu Tyr His 
            580                 585                 590         


Ser Asp Glu Gln Asn Asp Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn 
        595                 600                 605             


Thr Gly Ile Leu His Asp Glu Ile Leu Ile His Glu Glu Lys Gln Ile 
    610                 615                 620                 


Glu Val Val Glu Lys Met Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys 
625                 630                 635                 640 


Glu Lys Asp Ile Leu His Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala 
                645                 650                 655     


Met Leu Arg Leu Glu Leu Asp Thr Met Lys His Gln Ser Gln Leu Arg 
            660                 665                 670         


Glu Lys Lys Tyr Leu Glu Asp Ile Glu Ser Val Lys Lys Arg Asn Asp 
        675                 680                 685             


Asn Leu Leu Lys Ala Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp 
    690                 695                 700                 


Thr Ala Val Leu Val Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly 
705                 710                 715                 720 


Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly 
                725                 730                 735     


Arg Pro Arg Gln Gln Gly Met Met Gly Gly Met His Gln Lys Glu Ser 
            740                 745                 750         


Tyr Val Gly Lys Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys 
        755                 760                 765             


Tyr Pro Met Glu His Gly Ile Ile Thr Asn Trp Asp Asp Met Glu Lys 
    770                 775                 780                 


Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu 
785                 790                 795                 800 


His Pro Val Leu Leu Thr Glu Ala Thr Leu Asn Pro Lys Ala Asn Arg 
                805                 810                 815     


Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met 
            820                 825                 830         


Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Thr Ser Gly Arg Thr 
        835                 840                 845             


Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr His Thr Val Pro 
    850                 855                 860                 


Ile Tyr Glu Gly Asn Ala Leu Pro His Ala Thr Leu Arg Leu Asp Leu 
865                 870                 875                 880 


Ala Gly Arg Glu Leu Pro Asp Tyr Leu Met Lys Ile Leu Thr Glu His 
                885                 890                 895     


Gly Tyr Arg Phe Thr Thr Met Ala Glu Arg Glu Ile Val Arg Asp Ile 
            900                 905                 910         


Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala 
        915                 920                 925             


Thr Val Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp 
    930                 935                 940                 


Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala 
945                 950                 955                 960 


Leu Phe Gln Pro Cys Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu 
                965                 970                 975     


Thr Thr Phe Asn Ser Ile Met Lys Ser Asp Val Asp Ile Arg Lys Asp 
            980                 985                 990         


Leu Tyr Thr Asn Thr Val Leu Ser  Gly Gly Thr Thr Met  Tyr Pro Gly 
        995                 1000                 1005             


Met Ala  His Arg Met Gln Lys  Glu Ile Ala Ala Leu  Ala Pro Ser 
    1010                 1015                 1020             


Met Met  Lys Ile Arg Ile Ile  Ala Pro Pro Lys Arg  Lys Tyr Ser 
    1025                 1030                 1035             


Val Trp  Val Gly Gly Ser Ile  Leu Ala Ser Leu Ser  Thr Phe Gln 
    1040                 1045                 1050             


Gln Met  Trp Ile Ser Lys Gln  Glu Tyr Asp Glu Ser  Gly Pro Ser 
    1055                 1060                 1065             


Ile Val  His Arg Lys Cys Leu  
    1070                 1075 


<210>  24
<211>  111
<212>  PRT
<213>  Homo sapien

<400>  24

Met Phe Gly Gly Pro Gly Thr Gly Ser Arg Pro Ser Ser Thr Arg Ser 
1               5                   10                  15      


Tyr Val Thr Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg 
            20                  25                  30          


Pro Ser Thr Ser Arg Ser Leu Tyr Thr Ser Ser Pro Gly Gly Ala Tyr 
        35                  40                  45              


Val Thr Arg Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val 
    50                  55                  60                  


Arg Leu Leu Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn 
65                  70                  75                  80  


Thr Glu Phe Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu 
                85                  90                  95      


Leu Asn Asp Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110     


<210>  25
<211>  105
<212>  PRT
<213>  Homo sapien

<400>  25

Met Ala Lys Ile Ser Ser Pro Thr Glu Thr Glu Arg Cys Ile Glu Ser 
1               5                   10                  15      


Leu Ile Ala Val Phe Gln Lys Tyr Ala Gly Lys Asp Gly Tyr Asn Tyr 
            20                  25                  30          


Thr Leu Ser Lys Thr Glu Phe Leu Ser Phe Met Asn Thr Glu Leu Ala 
        35                  40                  45              


Ala Phe Thr Lys Asn Gln Lys Asp Pro Gly Val Leu Asp Arg Met Met 
    50                  55                  60                  


Lys Lys Leu Asp Thr Asn Ser Asp Gly Gln Leu Asp Phe Ser Glu Phe 
65                  70                  75                  80  


Leu Asn Leu Ile Gly Gly Leu Ala Met Ala Cys His Asp Ser Phe Leu 
                85                  90                  95      


Lys Ala Val Pro Ser Gln Lys Arg Thr 
            100                 105 


<210>  26
<211>  866
<212>  PRT
<213>  Homo sapien

<400>  26

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro 
625                 630                 635                 640 


Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser 
                645                 650                 655     


Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp 
            660                 665                 670         


Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr 
        675                 680                 685             


Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu 
    690                 695                 700                 


Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg 
705                 710                 715                 720 


Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala 
                725                 730                 735     


Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala 
            740                 745                 750         


Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu 
        755                 760                 765             


Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln 
    770                 775                 780                 


Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala 
785                 790                 795                 800 


Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn 
                805                 810                 815     


Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn 
            820                 825                 830         


Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly 
        835                 840                 845             


Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val 
    850                 855                 860                 


Thr Gln 
865     


<210>  27
<211>  426
<212>  PRT
<213>  Homo sapien

<400>  27

Met Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro Thr Gly 
1               5                   10                  15      


Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser Val Tyr 
            20                  25                  30          


Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile Leu Val 
        35                  40                  45              


Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro Phe Gly 
    50                  55                  60                  


Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly Ala Gly 
65                  70                  75                  80  


Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu Val Asp 
                85                  90                  95      


Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp Cys Leu 
            100                 105                 110         


Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly Ser Gly 
        115                 120                 125             


Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro Asp Arg 
    130                 135                 140                 


Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser Asp Thr 
145                 150                 155                 160 


Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu Val Glu 
                165                 170                 175     


Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr Asp Ile 
            180                 185                 190         


Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp Leu Asn 
        195                 200                 205             


His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu Arg Phe 
    210                 215                 220                 


Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn Met Val 
225                 230                 235                 240 


Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro Leu Thr 
                245                 250                 255     


Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu Leu Thr 
            260                 265                 270         


Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp Pro Arg 
        275                 280                 285             


His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg Met Ser 
    290                 295                 300                 


Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys Asn Ser 
305                 310                 315                 320 


Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala Val Cys 
                325                 330                 335     


Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile Gly Asn 
            340                 345                 350         


Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln Phe Thr 
        355                 360                 365             


Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly Glu Gly 
    370                 375                 380                 


Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn Asp Leu 
385                 390                 395                 400 


Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu Glu Glu 
                405                 410                 415     


Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
            420                 425     


<210>  28
<211>  172
<212>  PRT
<213>  Homo sapien

<400>  28

Met Ser Ser Lys Lys Ala Lys Thr Lys Thr Thr Lys Lys Arg Pro Gln 
1               5                   10                  15      


Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln 
            20                  25                  30          


Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe 
        35                  40                  45              


Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn 
    50                  55                  60                  


Pro Thr Asp Ala Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro 
65                  70                  75                  80  


Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly 
                85                  90                  95      


Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu 
            100                 105                 110         


Glu Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr 
        115                 120                 125             


Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg 
    130                 135                 140                 


Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr 
145                 150                 155                 160 


Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                165                 170         


<210>  29
<211>  323
<212>  PRT
<213>  Homo sapien

<400>  29

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp 
            


<210>  30
<211>  584
<212>  PRT
<213>  Homo sapien

<400>  30

Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser 
            20                  25                  30          


Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser 
        35                  40                  45              


Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly 
    50                  55                  60                  


Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Ser Phe Arg Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly 
                85                  90                  95      


Ser Tyr Gly Gly Ile Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe 
            100                 105                 110         


Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly 
    130                 135                 140                 


Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr 
145                 150                 155                 160 


Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly 
                165                 170                 175     


Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu 
            180                 185                 190         


Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn 
        195                 200                 205             


Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile 
    210                 215                 220                 


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg 
                245                 250                 255     


Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln 
            260                 265                 270         


Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu 
        275                 280                 285             


Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val 
    290                 295                 300                 


Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn 
305                 310                 315                 320 


Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala 
                325                 330                 335     


Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp 
            340                 345                 350         


Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu 
        355                 360                 365             


Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala 
    370                 375                 380                 


Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr 
385                 390                 395                 400 


Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu 
                405                 410                 415     


Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr 
            420                 425                 430         


Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr 
        435                 440                 445             


Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg 
    450                 455                 460                 


Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gly Gly His Gly Gly Gly His Gly Gly Ser Ser Gly 
                485                 490                 495     


Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
            500                 505                 510         


Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly 
        515                 520                 525             


Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly Tyr Gly Gly 
    530                 535                 540                 


Gly Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly 
545                 550                 555                 560 


Ser Ser Ser Gly Gly His Lys Ser Ser Ser Ser Gly Ser Val Gly Glu 
                565                 570                 575     


Ser Ser Ser Lys Gly Pro Arg Tyr 
            580                 


<210>  31
<211>  214
<212>  PRT
<213>  Homo sapien

<400>  31

Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu 
    210                 


<210>  32
<211>  553
<212>  PRT
<213>  Homo sapien

<400>  32

Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
        195                 200                 205             


Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp 
    210                 215                 220                 


Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys 
225                 230                 235                 240 


Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val 
                245                 250                 255     


Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr 
            260                 265                 270         


Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu 
        275                 280                 285             


Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly 
    290                 295                 300                 


Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala 
305                 310                 315                 320 


Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala 
                325                 330                 335     


Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala 
            340                 345                 350         


Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro 
        355                 360                 365             


Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn 
    370                 375                 380                 


Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe 
385                 390                 395                 400 


Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg 
                405                 410                 415     


Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr 
            420                 425                 430         


Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln 
        435                 440                 445             


Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly 
    450                 455                 460                 


Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala 
465                 470                 475                 480 


Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu 
                485                 490                 495     


Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu 
            500                 505                 510         


Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala 
        515                 520                 525             


Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val 
    530                 535                 540                 


Thr Asn Phe Leu Ala Gly Phe Glu Ala 
545                 550             


