                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Mnchen
 
<120>  RALEN-mediated genetic modification techniques

<130>  W1605 PCT

<150>  EP 13 16 3214.3
<151>  2013-04-10

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  144
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ODN-Rab38(G19V)

<400>  1
cacctcacaa ggagcacctg tacaagctgc tggtgatcgg cgacctggta gtgggcaaga       60

ccagcattat taaacggtac gtgcatcaaa atttctcctc tcattatcga gccaccattg      120

gtgtggactt cgcgctgaag gtgc                                             144


<210>  2
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HN-repeat

<400>  2

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys 
1               5                   10                  15      


Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Glu 
        35  


<210>  3
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NT-repeat

<400>  3

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys 
1               5                   10                  15      


Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Glu 
        35  


<210>  4
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ND-repeat

<400>  4

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asp Gly Gly Lys 
1               5                   10                  15      


Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Glu 
        35  


<210>  5
<211>  906
<212>  PRT
<213>  Ralstonia solanacearum

<400>  5

Met Ala Ala Leu Gly Tyr Ser Arg Glu Gln Ile Arg Lys Leu Lys Gln 
1               5                   10                  15      


Glu Ser Leu Ser Gly Val Ala Lys Tyr His Ala Pro Leu Thr Arg His 
            20                  25                  30          


Gly Phe Thr His Thr Asp Ile Cys Arg Ile Ser Arg Arg Trp Gln Ser 
        35                  40                  45              


Leu Arg Met Val Ala Lys Asn Tyr Pro Lys Leu Ile Ala Ala Leu Pro 
    50                  55                  60                  


Asp Leu Thr Arg Thr His Ile Val Asp Ile Ala Arg Gln Arg Ser Gly 
65                  70                  75                  80  


Asp Leu Ala Leu Glu Ala Leu Leu Pro Val Ala Thr Ala Leu Ala Ala 
                85                  90                  95      


Ala Pro Leu Arg Leu Arg Ala Ser Gln Ile Ala Ile Ile Ala Gln Cys 
            100                 105                 110         


Gly Glu Arg Pro Ala Ile Leu Ala Leu His Arg Leu Arg Arg Lys Leu 
        115                 120                 125             


Thr Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    130                 135                 140                 


Ala Asn Thr Gly Gly Lys Gln Ala Leu Gly Ala Ile Thr Thr Gln Leu 
145                 150                 155                 160 


Pro Ile Leu Arg Ala Ala Pro Tyr Glu Leu Ser Pro Glu Gln Val Val 
                165                 170                 175     


Ala Ile Ala Ser Asn Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys 
            180                 185                 190         


Ala Gln Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Pro Ala Leu Glu 
    210                 215                 220                 


Ala Val Lys Ala Leu Leu Leu Ala Leu Arg Ala Ala Pro Tyr Glu Leu 
225                 230                 235                 240 


Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Pro 
                245                 250                 255     


Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro 
            260                 265                 270         


Tyr Glu Leu Ser Thr Gly Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        275                 280                 285             


Gly Arg Gln Ala Leu Glu Ala Val Arg Glu Gln Leu Leu Ala Leu Arg 
    290                 295                 300                 


Ala Val Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Val Ile Ala Asn 
305                 310                 315                 320 


Ser Ile Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Val Gln Leu Pro 
                325                 330                 335     


Val Leu Arg Ala Ala Pro Tyr Glu Leu Asn Thr Glu Gln Val Val Ala 
            340                 345                 350         


Val Ala Ser Asn Lys Gly Gly Lys Gln Ala Leu Glu Ala Val Gly Ala 
        355                 360                 365             


Gln Leu Leu Ala Leu Arg Ala Val Pro Tyr Ala Leu Thr Thr Ala Gln 
    370                 375                 380                 


Val Val Ala Ile Ala Ser Asn Asp Gly Gly Lys Gln Ala Leu Glu Ala 
385                 390                 395                 400 


Val Gly Ala Gln Leu Leu Val Leu Arg Ala Val Pro Tyr Glu Leu Thr 
                405                 410                 415     


Thr Ala Gln Val Val Ala Ile Ala Ser Asn Asp Gly Gly Lys Gln Thr 
            420                 425                 430         


Leu Glu Val Ala Gly Ala Gln Leu Leu Ala Leu Arg Ala Val Pro Tyr 
        435                 440                 445             


Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
    450                 455                 460                 


Lys Gln Ala Leu Glu Ala Val Lys Thr Gln Leu Leu Ala Leu Arg Thr 
465                 470                 475                 480 


Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn 
                485                 490                 495     


Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln Leu Pro Ala 
            500                 505                 510         


Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile 
        515                 520                 525             


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln 
    530                 535                 540                 


Leu Leu Val Leu Arg Ala Ala Pro Tyr Gly Leu Ser Thr Ala Gln Val 
545                 550                 555                 560 


Val Ala Ile Ala Ala Asn Asn Gly Gly Lys Gln Ala Leu Glu Ala Val 
                565                 570                 575     


Arg Ala Leu Leu Pro Val Leu Arg Val Ala Pro Tyr Glu Leu Ser Thr 
            580                 585                 590         


Thr Arg Val Val Ser Ile Ala Cys Ile Gly Gly Arg Gln Ala Leu Glu 
        595                 600                 605             


Ala Ile Lys Thr His Met Pro Ala Leu Arg Gln Ala Pro Tyr Ser Leu 
    610                 615                 620                 


Ser His Glu Arg Val Val Ala Ile Val Cys Asn Gly Gly Arg Ser Ala 
625                 630                 635                 640 


Leu Glu Ala Ala Arg His Gly Leu Pro Val Arg Asp Ile Arg Arg Ile 
                645                 650                 655     


Arg Asn Arg Lys Thr Ser Asp Ala Thr Leu Pro Ala Pro Val Leu Gly 
            660                 665                 670         


Pro Thr Pro Gln Glu Leu Val Ala Val Leu His Phe Phe Arg Thr His 
        675                 680                 685             


Gln Gln Pro Arg Gln Ala Phe Val Asp Ala Leu Thr Ala Phe Gln Thr 
    690                 695                 700                 


Thr Arg Arg Ala Leu Leu Arg Leu Leu Ser Ser Ala Gly Val Thr Glu 
705                 710                 715                 720 


Ile Glu Ala Leu Gly Gly Met Ile Pro Asp Ala Ala Glu Arg Trp Gln 
                725                 730                 735     


Arg Leu Leu Gly Arg Leu Gly Ile Arg Pro Ala Thr Asp Thr Val Val 
            740                 745                 750         


Thr Ser Pro Asp Pro Met Gln Gly Phe Ala Gln Ser Leu Glu Arg Ser 
        755                 760                 765             


Leu Met Ser Ser Gly Thr Thr Glu Gln Ser Ala Ser Pro Ser Gln His 
    770                 775                 780                 


Arg Trp Pro Ala Gly Thr Ala Lys Thr Pro Glu Ser Ala Arg His Arg 
785                 790                 795                 800 


Leu Asp Asn Ala Ala Gln Pro Pro Met Gln Trp Pro Asp Gln Leu Val 
                805                 810                 815     


Trp Ser Gln Arg Arg Arg Cys Thr Ala Ser Ser Gln Thr Pro Pro Pro 
            820                 825                 830         


Gly Ala Ala Ser Val Pro Ala Asn Leu Gln Trp Gly Ala Arg Ala Gln 
        835                 840                 845             


Arg Thr Ser Ser Arg Leu Gln Pro Glu Leu Arg Pro Met Pro Ala Arg 
    850                 855                 860                 


Val Val Pro Ala Ser Ala Gln Pro Ser Pro Leu Gly Asp Leu Glu Phe 
865                 870                 875                 880 


Gly Leu Pro Asp Pro Gly Thr Pro Thr Ala Ala Asp Leu Ala Leu Asp 
                885                 890                 895     


Leu Asp Trp Leu Leu Gln Leu Leu Asp Leu 
            900                 905     


<210>  6
<211>  490
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RALEN-Rab-A

<400>  6

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys 
1               5                   10                  15      


Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Thr 
        35                  40                  45              


Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu 
    50                  55                  60                  


Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser Asn Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu 
                85                  90                  95      


Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val 
            100                 105                 110         


Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys 
        115                 120                 125             


Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu 
    130                 135                 140                 


Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu 
145                 150                 155                 160 


Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu 
                165                 170                 175     


Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro 
            180                 185                 190         


Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro 
        195                 200                 205             


Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asp Gly 
    210                 215                 220                 


Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg 
225                 230                 235                 240 


Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser 
                245                 250                 255     


His Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu 
            260                 265                 270         


Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala 
        275                 280                 285             


Ile Ala Ser Asn Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala 
    290                 295                 300                 


Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln 
305                 310                 315                 320 


Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys Pro Ala Leu Glu Ala 
                325                 330                 335     


Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser 
            340                 345                 350         


Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala 
        355                 360                 365             


Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr 
    370                 375                 380                 


Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly 
385                 390                 395                 400 


Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala 
                405                 410                 415     


Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His 
            420                 425                 430         


Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu 
        435                 440                 445             


Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Thr Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu 
465                 470                 475                 480 


Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu 
                485                 490 


<210>  7
<211>  490
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RALEN-Rab-B

<400>  7

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys 
1               5                   10                  15      


Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn 
        35                  40                  45              


Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu 
    50                  55                  60                  


Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser Asn Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu 
                85                  90                  95      


Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val 
            100                 105                 110         


Ala Ile Ala Ser Asn Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Lys 
        115                 120                 125             


Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu 
    130                 135                 140                 


Gln Val Val Ala Ile Ala Ser Asn Asp Gly Gly Lys Pro Ala Leu Glu 
145                 150                 155                 160 


Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu 
                165                 170                 175     


Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro 
            180                 185                 190         


Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro 
        195                 200                 205             


Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly 
    210                 215                 220                 


Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg 
225                 230                 235                 240 


Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser 
                245                 250                 255     


Asn Thr Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu 
            260                 265                 270         


Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala 
        275                 280                 285             


Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala 
    290                 295                 300                 


Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln 
305                 310                 315                 320 


Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala 
                325                 330                 335     


Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser 
            340                 345                 350         


Thr Glu Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys Pro Ala 
        355                 360                 365             


Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr 
    370                 375                 380                 


Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly 
385                 390                 395                 400 


Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala 
                405                 410                 415     


Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu 
        435                 440                 445             


Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu 
465                 470                 475                 480 


Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu 
                485                 490 


<210>  8
<211>  1486
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RALEN-Rab-A

<400>  8
gaagacaact cagtaccgag caggtagtgg ccatcgccag ccacaatggc ggcaagccgg       60

cgttggaggc agtcaaggca ctgttgctgg aactgcgcgc agcgccctac gagctcagta      120

ccgagcaggt agtggccatc gccagcaata ccggcggcaa gccggcgttg gaggcagtca      180

aggcactgtt gctggaactg cgcgcagcgc cctacgagct cagtaccgag caggtagtgg      240

ccatcgccag caatgatggc ggcaagccgg cgttggaggc agtcaaggca ctgttgctgg      300

aactgcgcgc agcgccctac gagctcagta ccgagcaggt agtggccatc gccagccaca      360

atggcggcaa gccggcgttg gaggcagtca aggcactgtt gctggaactg cgcgcagcgc      420

cctacgagct cagtaccgag caggtagtgg ccatcgccag ccacaatggc ggcaagccgg      480

cgttggaggc agtcaaggca ctgttgctgg aactgcgcgc agcgccctac gagctcagta      540

ccgagcaggt agtggccatc gccagccaca atggcggcaa gccggcgttg gaggcagtca      600

aggcactgtt gctggaactg cgcgcagcgc cctacgagct cagtaccgag caggtagtgg      660

ccatcgccag caatgatggc ggcaagccgg cgttggaggc agtcaaggca ctgttgctgg      720

aactgcgcgc agcgccctac gagctcagta ccgagcaggt agtggccatc gccagccaca      780

atggcggcaa gccggcgttg gaggcagtca aggcactgtt gctggaactg cgcgcagcgc      840

cctacgagct cagtaccgag caggtagtgg ccatcgccag caatgatggc ggcaagccgg      900

cgttggaggc agtcaaggca ctgttgctgg aactgcgcgc agcgccctac gagctcagta      960

ccgagcaggt agtggccatc gccagcaata ccggcggcaa gccggcgttg gaggcagtca     1020

aggcactgtt gctggaactg cgcgcagcgc cctacgagct cagtaccgag caggtagtgg     1080

ccatcgccag ccacaatggc ggcaagccgg cgttggaggc agtcaaggca ctgttgctgg     1140

aactgcgcgc agcgccctac gagctcagta ccgagcaggt agtggccatc gccagcaata     1200

ccggcggcaa gccggcgttg gaggcagtca aggcactgtt gctggaactg cgcgcagcgc     1260

cctacgagct cagtaccgag caggtagtgg ccatcgccag ccacaatggc ggcaagccgg     1320

cgttggaggc agtcaaggca ctgttgctgg aactgcgcgc agcgccctac gagctcagta     1380

ccgagcaggt agtggccatc gccagcaata ccggcggcaa gccggcgttg gaggcagtca     1440

aggcactgtt gctggaactg cgcgcagcgc cctacgagtt gtcttc                    1486


<210>  9
<211>  1486
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RALEN-Rab-B

<400>  9
gaagacaact cagtaccgag caggtagtgg ccatcgccag ccacaatggc ggcaagccgg       60

cgttggaggc agtcaaggca ctgttgctgg aactgcgcgc agcgccctac gagctcagta      120

ccgagcaggt agtggccatc gccagccaca atggcggcaa gccggcgttg gaggcagtca      180

aggcactgtt gctggaactg cgcgcagcgc cctacgagct cagtaccgag caggtagtgg      240

ccatcgccag caatgatggc ggcaagccgg cgttggaggc agtcaaggca ctgttgctgg      300

aactgcgcgc agcgccctac gagctcagta ccgagcaggt agtggccatc gccagcaatg      360

atggcggcaa gccggcgttg gaggcagtca aggcactgtt gctggaactg cgcgcagcgc      420

cctacgagct cagtaccgag caggtagtgg ccatcgccag caatgatggc ggcaagccgg      480

cgttggaggc agtcaaggca ctgttgctgg aactgcgcgc agcgccctac gagctcagta      540

ccgagcaggt agtggccatc gccagccaca atggcggcaa gccggcgttg gaggcagtca      600

aggcactgtt gctggaactg cgcgcagcgc cctacgagct cagtaccgag caggtagtgg      660

ccatcgccag ccacaatggc ggcaagccgg cgttggaggc agtcaaggca ctgttgctgg      720

aactgcgcgc agcgccctac gagctcagta ccgagcaggt agtggccatc gccagcaata      780

ccggcggcaa gccggcgttg gaggcagtca aggcactgtt gctggaactg cgcgcagcgc      840

cctacgagct cagtaccgag caggtagtgg ccatcgccag ccacaatggc ggcaagccgg      900

cgttggaggc agtcaaggca ctgttgctgg aactgcgcgc agcgccctac gagctcagta      960

ccgagcaggt agtggccatc gccagccaca atggcggcaa gccggcgttg gaggcagtca     1020

aggcactgtt gctggaactg cgcgcagcgc cctacgagct cagtaccgag caggtagtgg     1080

ccatcgccag caataccggc ggcaagccgg cgttggaggc agtcaaggca ctgttgctgg     1140

aactgcgcgc agcgccctac gagctcagta ccgagcaggt agtggccatc gccagccaca     1200

atggcggcaa gccggcgttg gaggcagtca aggcactgtt gctggaactg cgcgcagcgc     1260

cctacgagct cagtaccgag caggtagtgg ccatcgccag caatgatggc ggcaagccgg     1320

cgttggaggc agtcaaggca ctgttgctgg aactgcgcgc agcgccctac gagctcagta     1380

ccgagcaggt agtggccatc gccagccaca atggcggcaa gccggcgttg gaggcagtca     1440

aggcactgtt gctggaactg cgcgcagcgc cctacgagtt gtcttc                    1486


<210>  10
<211>  489
<212>  PRT
<213>  Ralstonia solanacearum

<220>
<221> variant
<222> 141
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 142
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 143
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 144
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 145
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 146
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 147
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 148
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 149
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 150
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 151
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 152
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 153
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 154
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 155
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 156
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 157
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 158
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 159
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 160
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 161
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 162
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 163
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 164
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 165
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 166
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 167
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 168
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 169
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 170
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 171
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 172
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 173
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 174
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 175
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 176
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 177
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 178
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 179
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 180
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 181
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 182
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 183
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 184
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 185
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 186
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 187
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 188
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 189
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 190
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 191
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 192
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 193
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 194
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 195
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 196
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 197
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 198
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 199
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 200
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 201
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 202
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 203
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 204
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 205
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 206
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 207
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 208
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 209
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 210
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 211
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 212
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 213
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 214
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 215
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 216
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 217
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 218
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 219
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 220
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 221
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 222
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 223
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 224
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 225
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 226
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 227
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 228
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 229
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 230
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 231
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 232
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 233
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 234
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 235
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 236
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 237
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 238
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 239
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 240
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 241
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 242
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 243
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 244
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 245
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 246
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 247
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 248
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 249
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 250
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 251
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 252
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 253
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 254
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 255
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 256
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 257
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 258
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 259
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 260
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 261
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 262
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 263
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 264
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 265
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 266
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 267
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 268
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 269
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 270
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 271
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 272
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 273
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 274
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 275
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 276
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 277
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 278
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 279
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 280
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 281
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 282
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 283
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 284
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 285
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 286
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 287
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 288
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 289
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 290
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 291
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 292
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 293
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 294
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 295
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 296
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 297
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 298
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 299
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 300
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 301
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 302
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 303
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 304
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 305
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 306
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 307
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 308
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 309
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 310
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 311
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 312
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 313
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 314
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 315
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 316
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 317
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 318
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 319
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 320
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 321
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 322
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 323
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 324
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 325
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 326
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 327
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 328
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 329
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 330
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 331
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 332
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 333
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 334
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 335
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 336
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 337
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 338
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 339
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 340
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 341
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 342
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 343
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 344
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 345
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 346
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 347
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 348
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 349
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 350
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<400>  10

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Ala Val Lys Ala Asp Leu Leu Asp Leu Arg Gly Ala 
            20                  25                  30          


Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn 
        35                  40                  45              


Gly Gly Lys Leu Ala Leu Glu Ala Val Lys Ala His Leu Leu Asp Leu 
    50                  55                  60                  


Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln Leu 
                85                  90                  95      


Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Ala Gln Val Val 
            100                 105                 110         


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Gly Ile Gly 
        115                 120                 125             


Glu Gln Leu Leu Lys Leu Arg Thr Ala Pro Tyr Gly Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Ser 
            340                 345                 350         


Thr Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly Lys Gln Ala 
        355                 360                 365             


Leu Glu Ala Val Arg Ala Leu Phe Arg Gly Leu Arg Ala Ala Pro Tyr 
    370                 375                 380                 


Gly Leu Ser Thr Ala Gln Val Val Ala Val Ala Ser Ser Asn Gly Gly 
385                 390                 395                 400 


Lys Gln Ala Leu Glu Ala Val Trp Ala Leu Leu Pro Val Leu Arg Ala 
                405                 410                 415     


Thr Pro Tyr Asp Leu Asn Thr Ala Gln Val Val Ala Ile Ala Ser His 
            420                 425                 430         


Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Trp Ala Lys Leu Pro Val 
        435                 440                 445             


Leu Arg Gly Val Pro Tyr Glu Leu Ser Thr Ala Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Cys Ile Ser Gly Gln Gln Ala Leu Glu Ala Ile Glu Ala His Met 
465                 470                 475                 480 


Pro Thr Leu Arg Gln Ala Pro His Ser 
                485                 


<210>  11
<211>  6636
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-YP-Fok

<400>  11
ggcgcgccgg attcgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc       60

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc      120

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      180

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      240

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      300

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      360

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      420

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      480

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      540

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc      600

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag      660

cgcgcggcgg gcgggagtcg ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc      720

ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga      780

cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct      840

gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg gggagcggct      900

cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc gcgctgcccg      960

gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt gtgcgcgagg     1020

ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg aacaaaggct     1080

gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc     1140

aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc     1200

tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg     1260

tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc     1320

cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat     1380

cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg aaatctggga     1440

ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg     1500

aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc     1560

ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg     1620

gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct     1680

ttttcctaca gatccttaat taataatacg actcactata ggggccgcca ccatgggacc     1740

taagaaaaag aggaaggtgg cggccgctga ctacaaggat gacgacgata aaccaggtgg     1800

cggaggtagt ggcggaggtg gggtacccat ggccgctctt ggctattcta gggagcaaat     1860

taggaaactt aagcaggaat ctttatctgg tgtcgcaaag tatcacgctc ctctaaccag     1920

acatgggttc acacatactg acatttgtcg tatatcaaga cgttggcaat ccctccgaat     1980

ggtagccaaa aactacccta aattaattgc agctttacct gatctaacac gaactcatat     2040

agttgacatt gctcgtcagc gatccggaga tctagctctc gaagctctat tacctgttgc     2100

tacggctctc gccgcggcgc cgcttcgcct cagagcatcc caaatcgcaa tcatagctca     2160

gtgtggagag aggccagcta tactcgctct gcatagatta aggagaaagc tcacgggtgc     2220

tccacttaac ctcacacccc aacaagtcgt cgctatagca gcgaataccg gcggtaagca     2280

ggcacttggt gcgatcacca ctcagttgcc gattttaaga gctgcaccct atgagctctc     2340

tccagagcag gtggtggcca ttgctagcaa taatggtgga aaacctgctc tcgaagcggt     2400

taaggctcaa cttttggagc tcagagcggc tccttacgaa ctcatgagac gacgtctcac     2460

gagttgagca cgaccagagt ggtgtcaatc gcgtgcatcg gtggaaggca ggctttggaa     2520

gctataaaaa cacatatgcc agctttaaga caggcaccat actctctcag ccacgagcga     2580

gttgtggcaa ttgtgtgtaa tggaggacga agtgcccttg aagccgcacg acatggactc     2640

cctgttagag acataagaag aattcgtaat aggaagacgt cagatgcaac tctacctgcc     2700

ggatccgatc gtttaaacca gctcgtgaaa agcgaactcg aagaaaagaa aagtgaactg     2760

cggcacaaac tgaaatacgt cccacatgaa tacattgagc tgatcgagat tgctaggaac     2820

tccacccagg acagaatcct cgagatgaaa gtgatggaat tctttatgaa agtctacggg     2880

tatcggggca agcacctggg cggatctcgc aaaccagatg gggcaatcta cactgtgggt     2940

agtcccatcg actatggcgt gattgtcgat accaaggcct acagtggggg ttataatctg     3000

cccattggac aggctgacga gatgcagcga tacgtggagg aaaaccagac aagaaataag     3060

catatcaacc ccaatgagtg gtggaaagtg tatcctagct ccgtcactga attcaagttt     3120

ctcttcgtgt caggccactt taagggaaac tacaaagcac agctgaccag gctcaatcat     3180

attacaaact gcaatggcgc cgtgctgagc gtcgaggaac tgctcatcgg cggagagatg     3240

atcaaggccg gcacactcac cctggaggag gtccgccgaa aattcaataa cggggaaatc     3300

aacttctgaa cgcgtaaatg attgcagatc cactagttct agaattccag ctgagcgccg     3360

gtcgctacca ttaccagttg gtctggtgtc aaaaataata ataaccgggc aggggggatc     3420

tgcatggatc tttgtgaagg aaccttactt ctgtggtgtg acataattgg acaaactacc     3480

tacagagatt taaagctcta aggtaaatat aaaattttta agtgtataat gtgttaaact     3540

actgattcta attgtttgtg tattttagat tccaacctat ggaactgatg aatgggagca     3600

gtggtggaat gccagatcca gacatgataa gatacattga tgagtttgga caaaccacaa     3660

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     3720

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     3780

aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     3840

tggctgatta tgatctgcgg ccgccactgg ccgtcgtttt acaacgtcgt gactgggaaa     3900

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     3960

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     4020

ggaacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     4080

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     4140

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     4200

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     4260

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     4320

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     4380

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     4440

ttaacgcgaa ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa     4500

tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat     4560

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca     4620

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca     4680

cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta     4740

catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt     4800

tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc     4860

cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc     4920

accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc     4980

cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa     5040

ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga     5100

accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat     5160

ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca     5220

attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc     5280

ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat     5340

tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag     5400

tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa     5460

gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca     5520

tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc     5580

ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc     5640

ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc     5700

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt     5760

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt     5820

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc     5880

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa     5940

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac     6000

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg     6060

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga     6120

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact     6180

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa     6240

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc     6300

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg     6360

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat     6420

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt     6480

tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta     6540

ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg     6600

ataacaattt cacacaggaa acagctatga ccatga                               6636


<210>  12
<211>  489
<212>  PRT
<213>  Ralstonia solanacearum

<220>
<221> variant
<222> 106
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 107
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 108
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 109
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 110
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 111
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 112
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 113
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 114
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 115
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 116
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 117
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 118
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 119
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 120
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 121
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 122
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 123
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 124
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 125
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 126
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 127
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 128
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 129
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 130
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 131
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 132
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 133
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 134
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 135
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 136
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 137
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 138
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 139
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 140
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 141
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 142
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 143
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 144
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 145
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 146
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 147
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 148
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 149
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 150
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 151
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 152
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 153
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 154
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 155
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 156
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 157
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 158
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 159
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 160
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 161
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 162
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 163
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 164
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 165
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 166
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 167
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 168
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 169
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 170
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 171
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 172
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 173
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 174
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 175
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 176
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 177
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 178
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 179
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 180
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 181
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 182
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 183
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 184
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 185
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 186
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 187
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 188
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 189
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 190
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 191
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 192
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 193
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 194
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 195
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 196
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 197
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 198
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 199
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 200
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 201
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 202
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 203
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 204
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 205
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 206
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 207
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 208
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 209
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 210
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 211
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 212
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 213
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 214
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 215
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 216
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 217
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 218
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 219
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 220
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 221
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 222
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 223
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 224
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 225
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 226
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 227
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 228
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 229
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 230
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 231
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 232
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 233
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 234
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 235
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 236
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 237
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 238
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 239
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 240
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 241
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 242
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 243
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 244
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 245
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 246
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 247
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 248
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 249
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 250
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 251
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 252
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 253
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 254
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 255
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 256
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 257
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 258
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 259
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 260
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 261
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 262
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 263
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 264
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 265
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 266
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 267
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 268
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 269
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 270
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 271
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 272
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 273
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 274
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 275
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 276
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 277
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 278
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 279
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 280
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 281
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 282
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 283
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 284
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 285
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 286
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 287
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 288
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 289
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 290
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 291
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 292
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 293
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 294
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 295
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 296
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 297
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 298
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 299
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 300
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 301
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 302
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 303
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 304
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 305
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 306
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 307
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 308
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 309
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 310
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 311
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 312
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 313
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 314
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 315
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<400>  12

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Lys Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Ala Val Lys Ala His Leu Leu Asp Leu Leu Gly Ala 
            20                  25                  30          


Pro Tyr Val Leu Asn Thr Glu Gln Val Val Ala Ile Ala Ser His Asn 
        35                  40                  45              


Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp Leu Leu Asp Leu 
    50                  55                  60                  


Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp Leu 
                85                  90                  95      


Leu Glu Leu Arg Gly Ala Pro Tyr Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Ser Thr Ala Gln 
305                 310                 315                 320 


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Ala 
                325                 330                 335     


Val Gly Ala Gln Leu Val Glu Leu Arg Ala Ala Pro Tyr Ala Leu Ser 
            340                 345                 350         


Thr Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
        355                 360                 365             


Leu Glu Ala Val Gly Ala Gln Leu Val Ala Leu Arg Ala Ala Pro Tyr 
    370                 375                 380                 


Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Ser His Gly Gly 
385                 390                 395                 400 


Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Leu Pro Val Leu Arg Ala 
                405                 410                 415     


Thr Pro Tyr Asp Leu Asn Thr Ala Gln Val Val Ala Ile Ala Ser His 
            420                 425                 430         


Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Arg Ala Lys Leu Pro Val 
        435                 440                 445             


Leu Arg Gly Val Pro Tyr Ala Leu Ser Thr Ala Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Cys Ile Ser Gly Gln Gln Ala Leu Glu Ala Ile Glu Ala His Met 
465                 470                 475                 480 


Pro Thr Leu Arg Gln Ala Pro His Ser 
                485                 


<210>  13
<211>  174
<212>  PRT
<213>  Ralstonia solanacearum

<400>  13

Leu Ser Thr Ala Gln Leu Val Ala Ile Ala Ser Asn Pro Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Ala Val Arg Ala Pro Phe Arg Glu Val Arg Ala Ala 
            20                  25                  30          


Pro Tyr Ala Leu Ser Pro Glu Gln Val Val Ala Ile Ala Ser Asn His 
        35                  40                  45              


Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Arg Gly Leu 
    50                  55                  60                  


Arg Ala Ala Pro Tyr Gly Leu Ser Thr Ala Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser Ser Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Trp Ala Leu Leu 
                85                  90                  95      


Pro Val Leu Arg Ala Thr Pro Tyr Asp Leu Ser Thr Ala Gln Val Val 
            100                 105                 110         


Ala Ile Ala Ser His Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Trp 
        115                 120                 125             


Ala Lys Leu Pro Val Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Ala 
    130                 135                 140                 


Gln Val Val Ala Ile Ala Cys Ile Ser Gly Gln Gln Ala Leu Glu Ala 
145                 150                 155                 160 


Ile Glu Ala His Met Pro Thr Leu Arg Gln Ala Pro His Ser 
                165                 170                 


<210>  14
<211>  139
<212>  PRT
<213>  Ralstonia solanacearum

<400>  14

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Arg Gly Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Gly Leu Ser Thr Ala Gln Val Val Ala Ile Ala Ser Ser Asn 
        35                  40                  45              


Gly Gly Lys Gln Ala Leu Glu Ala Val Trp Ala Leu Leu Pro Val Leu 
    50                  55                  60                  


Arg Ala Thr Pro Tyr Asp Leu Asn Thr Ala Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser His Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Trp Ala Lys Leu 
                85                  90                  95      


Pro Val Leu Arg Gly Val Pro Tyr Ala Leu Ser Thr Ala Gln Val Val 
            100                 105                 110         


Ala Ile Ala Cys Ile Ser Gly Gln Gln Ala Leu Glu Ala Ile Glu Ala 
        115                 120                 125             


His Met Pro Thr Leu Arg Gln Ala Pro His Ser 
    130                 135                 


<210>  15
<211>  89
<212>  PRT
<213>  Ralstonia solanacearum

<400>  15

Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Pro Ala Leu Glu Ala Val Trp Ala Lys Leu Pro Val Leu Arg Gly Val 
            20                  25                  30          


Pro Tyr Ala Leu Ser Thr Ala Gln Val Val Ala Ile Ala Cys Ile Ser 
        35                  40                  45              


Gly Gln Gln Ala Leu Glu Ala Ile Glu Ala His Met Pro Thr Leu Arg 
    50                  55                  60                  


Gln Ala Pro His Ser Leu Ser Pro Glu Arg Val Ala Ala Ile Ala Cys 
65                  70                  75                  80  


Ile Gly Gly Arg Ser Ala Val Glu Ala 
                85


<210>  16
<211>  8083
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-YP-RALEN-RabA-Fok

<400>  16
ggcgcgccgg attcgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc       60

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc      120

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      180

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      240

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      300

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      360

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      420

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      480

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      540

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc      600

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag      660

cgcgcggcgg gcgggagtcg ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc      720

ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga      780

cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct      840

gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg gggagcggct      900

cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc gcgctgcccg      960

gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt gtgcgcgagg     1020

ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg aacaaaggct     1080

gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc     1140

aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc     1200

tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg     1260

tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc     1320

cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat     1380

cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg aaatctggga     1440

ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg     1500

aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc     1560

ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg     1620

gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct     1680

ttttcctaca gatccttaat taataatacg actcactata ggggccgcca ccatgggacc     1740

taagaaaaag aggaaggtgg cggccgctga ctacaaggat gacgacgata aaccaggtgg     1800

cggaggtagt ggcggaggtg gggtacccat ggccgctctt ggctattcta gggagcaaat     1860

taggaaactt aagcaggaat ctttatctgg tgtcgcaaag tatcacgctc ctctaaccag     1920

acatgggttc acacatactg acatttgtcg tatatcaaga cgttggcaat ccctccgaat     1980

ggtagccaaa aactacccta aattaattgc agctttacct gatctaacac gaactcatat     2040

agttgacatt gctcgtcagc gatccggaga tctagctctc gaagctctat tacctgttgc     2100

tacggctctc gccgcggcgc cgcttcgcct cagagcatcc caaatcgcaa tcatagctca     2160

gtgtggagag aggccagcta tactcgctct gcatagatta aggagaaagc tcacgggtgc     2220

tccacttaac ctcacacccc aacaagtcgt cgctatagca gcgaataccg gcggtaagca     2280

ggcacttggt gcgatcacca ctcagttgcc gattttaaga gctgcaccct atgagctctc     2340

tccagagcag gtggtggcca ttgctagcaa taatggtgga aaacctgctc tcgaagcggt     2400

taaggctcaa cttttggagc tcagagcggc tccttacgaa ctcagtaccg agcaggtagt     2460

ggccatcgcc agccacaatg gcggcaagcc ggcgttggag gcagtcaagg cactgttgct     2520

ggaactgcgc gcagcgccct acgagctcag taccgagcag gtagtggcca tcgccagcaa     2580

taccggcggc aagccggcgt tggaggcagt caaggcactg ttgctggaac tgcgcgcagc     2640

gccctacgag ctcagtaccg agcaggtagt ggccatcgcc agcaatgatg gcggcaagcc     2700

ggcgttggag gcagtcaagg cactgttgct ggaactgcgc gcagcgccct acgagctcag     2760

taccgagcag gtagtggcca tcgccagcca caatggcggc aagccggcgt tggaggcagt     2820

caaggcactg ttgctggaac tgcgcgcagc gccctacgag ctcagtaccg agcaggtagt     2880

ggccatcgcc agccacaatg gcggcaagcc ggcgttggag gcagtcaagg cactgttgct     2940

ggaactgcgc gcagcgccct acgagctcag taccgagcag gtagtggcca tcgccagcca     3000

caatggcggc aagccggcgt tggaggcagt caaggcactg ttgctggaac tgcgcgcagc     3060

gccctacgag ctcagtaccg agcaggtagt ggccatcgcc agcaatgatg gcggcaagcc     3120

ggcgttggag gcagtcaagg cactgttgct ggaactgcgc gcagcgccct acgagctcag     3180

taccgagcag gtagtggcca tcgccagcca caatggcggc aagccggcgt tggaggcagt     3240

caaggcactg ttgctggaac tgcgcgcagc gccctacgag ctcagtaccg agcaggtagt     3300

ggccatcgcc agcaatgatg gcggcaagcc ggcgttggag gcagtcaagg cactgttgct     3360

ggaactgcgc gcagcgccct acgagctcag taccgagcag gtagtggcca tcgccagcaa     3420

taccggcggc aagccggcgt tggaggcagt caaggcactg ttgctggaac tgcgcgcagc     3480

gccctacgag ctcagtaccg agcaggtagt ggccatcgcc agccacaatg gcggcaagcc     3540

ggcgttggag gcagtcaagg cactgttgct ggaactgcgc gcagcgccct acgagctcag     3600

taccgagcag gtagtggcca tcgccagcaa taccggcggc aagccggcgt tggaggcagt     3660

caaggcactg ttgctggaac tgcgcgcagc gccctacgag ctcagtaccg agcaggtagt     3720

ggccatcgcc agccacaatg gcggcaagcc ggcgttggag gcagtcaagg cactgttgct     3780

ggaactgcgc gcagcgccct acgagctcag taccgagcag gtagtggcca tcgccagcaa     3840

taccggcggc aagccggcgt tggaggcagt caaggcactg ttgctggaac tgcgcgcagc     3900

gccctacgag ttgagcacga ccagagtggt gtcaatcgcg tgcatcggtg gaaggcaggc     3960

tttggaagct ataaaaacac atatgccagc tttaagacag gcaccatact ctctcagcca     4020

cgagcgagtt gtggcaattg tgtgtaatgg aggacgaagt gcccttgaag ccgcacgaca     4080

tggactccct gttagagaca taagaagaat tcgtaatagg aagacgtcag atgcaactct     4140

acctgccgga tccgatcgtt taaaccagct cgtgaaaagc gaactcgaag aaaagaaaag     4200

tgaactgcgg cacaaactga aatacgtccc acatgaatac attgagctga tcgagattgc     4260

taggaactcc acccaggaca gaatcctcga gatgaaagtg atggaattct ttatgaaagt     4320

ctacgggtat cggggcaagc acctgggcgg atctcgcaaa ccagatgggg caatctacac     4380

tgtgggtagt cccatcgact atggcgtgat tgtcgatacc aaggcctaca gtgggggtta     4440

taatctgccc attggacagg ctgacgagat gcagcgatac gtggaggaaa accagacaag     4500

aaataagcat atcaacccca atgagtggtg gaaagtgtat cctagctccg tcactgaatt     4560

caagtttctc ttcgtgtcag gccactttaa gggaaactac aaagcacagc tgaccaggct     4620

caatcatatt acaaactgca atggcgccgt gctgagcgtc gaggaactgc tcatcggcgg     4680

agagatgatc aaggccggca cactcaccct ggaggaggtc cgccgaaaat tcaataacgg     4740

ggaaatcaac ttctgaacgc gtaaatgatt gcagatccac tagttctaga attccagctg     4800

agcgccggtc gctaccatta ccagttggtc tggtgtcaaa aataataata accgggcagg     4860

ggggatctgc atggatcttt gtgaaggaac cttacttctg tggtgtgaca taattggaca     4920

aactacctac agagatttaa agctctaagg taaatataaa atttttaagt gtataatgtg     4980

ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga actgatgaat     5040

gggagcagtg gtggaatgcc agatccagac atgataagat acattgatga gtttggacaa     5100

accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct     5160

ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt     5220

atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa     5280

tgtggtatgg ctgattatga tctgcggccg ccactggccg tcgttttaca acgtcgtgac     5340

tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc     5400

tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat     5460

ggcgaatgga acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc     5520

agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc     5580

tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg     5640

ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca     5700

cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc     5760

tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct     5820

tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa     5880

caaaaattta acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc     5940

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     6000

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     6060

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     6120

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     6180

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     6240

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     6300

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     6360

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     6420

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     6480

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     6540

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     6600

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     6660

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     6720

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     6780

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     6840

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     6900

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     6960

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     7020

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     7080

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     7140

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7200

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7260

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     7320

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     7380

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     7440

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     7500

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     7560

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     7620

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7680

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     7740

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     7800

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     7860

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     7920

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     7980

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     8040

tgagcggata acaatttcac acaggaaaca gctatgacca tga                       8083


<210>  17
<211>  8083
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-YP-RabB-Fok

<400>  17
ggcgcgccgg attcgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc       60

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc      120

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      180

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      240

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      300

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      360

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      420

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      480

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      540

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc      600

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag      660

cgcgcggcgg gcgggagtcg ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc      720

ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga      780

cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct      840

gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg gggagcggct      900

cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc gcgctgcccg      960

gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt gtgcgcgagg     1020

ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg aacaaaggct     1080

gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc     1140

aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc     1200

tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg     1260

tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc     1320

cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat     1380

cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg aaatctggga     1440

ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg     1500

aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc     1560

ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg     1620

gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct     1680

ttttcctaca gatccttaat taataatacg actcactata ggggccgcca ccatgggacc     1740

taagaaaaag aggaaggtgg cggccgctga ctacaaggat gacgacgata aaccaggtgg     1800

cggaggtagt ggcggaggtg gggtacccat ggccgctctt ggctattcta gggagcaaat     1860

taggaaactt aagcaggaat ctttatctgg tgtcgcaaag tatcacgctc ctctaaccag     1920

acatgggttc acacatactg acatttgtcg tatatcaaga cgttggcaat ccctccgaat     1980

ggtagccaaa aactacccta aattaattgc agctttacct gatctaacac gaactcatat     2040

agttgacatt gctcgtcagc gatccggaga tctagctctc gaagctctat tacctgttgc     2100

tacggctctc gccgcggcgc cgcttcgcct cagagcatcc caaatcgcaa tcatagctca     2160

gtgtggagag aggccagcta tactcgctct gcatagatta aggagaaagc tcacgggtgc     2220

tccacttaac ctcacacccc aacaagtcgt cgctatagca gcgaataccg gcggtaagca     2280

ggcacttggt gcgatcacca ctcagttgcc gattttaaga gctgcaccct atgagctctc     2340

tccagagcag gtggtggcca ttgctagcaa taatggtgga aaacctgctc tcgaagcggt     2400

taaggctcaa cttttggagc tcagagcggc tccttacgaa ctcagtaccg agcaggtagt     2460

ggccatcgcc agccacaatg gcggcaagcc ggcgttggag gcagtcaagg cactgttgct     2520

ggaactgcgc gcagcgccct acgagctcag taccgagcag gtagtggcca tcgccagcca     2580

caatggcggc aagccggcgt tggaggcagt caaggcactg ttgctggaac tgcgcgcagc     2640

gccctacgag ctcagtaccg agcaggtagt ggccatcgcc agcaatgatg gcggcaagcc     2700

ggcgttggag gcagtcaagg cactgttgct ggaactgcgc gcagcgccct acgagctcag     2760

taccgagcag gtagtggcca tcgccagcaa tgatggcggc aagccggcgt tggaggcagt     2820

caaggcactg ttgctggaac tgcgcgcagc gccctacgag ctcagtaccg agcaggtagt     2880

ggccatcgcc agcaatgatg gcggcaagcc ggcgttggag gcagtcaagg cactgttgct     2940

ggaactgcgc gcagcgccct acgagctcag taccgagcag gtagtggcca tcgccagcca     3000

caatggcggc aagccggcgt tggaggcagt caaggcactg ttgctggaac tgcgcgcagc     3060

gccctacgag ctcagtaccg agcaggtagt ggccatcgcc agccacaatg gcggcaagcc     3120

ggcgttggag gcagtcaagg cactgttgct ggaactgcgc gcagcgccct acgagctcag     3180

taccgagcag gtagtggcca tcgccagcaa taccggcggc aagccggcgt tggaggcagt     3240

caaggcactg ttgctggaac tgcgcgcagc gccctacgag ctcagtaccg agcaggtagt     3300

ggccatcgcc agccacaatg gcggcaagcc ggcgttggag gcagtcaagg cactgttgct     3360

ggaactgcgc gcagcgccct acgagctcag taccgagcag gtagtggcca tcgccagcca     3420

caatggcggc aagccggcgt tggaggcagt caaggcactg ttgctggaac tgcgcgcagc     3480

gccctacgag ctcagtaccg agcaggtagt ggccatcgcc agcaataccg gcggcaagcc     3540

ggcgttggag gcagtcaagg cactgttgct ggaactgcgc gcagcgccct acgagctcag     3600

taccgagcag gtagtggcca tcgccagcca caatggcggc aagccggcgt tggaggcagt     3660

caaggcactg ttgctggaac tgcgcgcagc gccctacgag ctcagtaccg agcaggtagt     3720

ggccatcgcc agcaatgatg gcggcaagcc ggcgttggag gcagtcaagg cactgttgct     3780

ggaactgcgc gcagcgccct acgagctcag taccgagcag gtagtggcca tcgccagcca     3840

caatggcggc aagccggcgt tggaggcagt caaggcactg ttgctggaac tgcgcgcagc     3900

gccctacgag ttgagcacga ccagagtggt gtcaatcgcg tgcatcggtg gaaggcaggc     3960

tttggaagct ataaaaacac atatgccagc tttaagacag gcaccatact ctctcagcca     4020

cgagcgagtt gtggcaattg tgtgtaatgg aggacgaagt gcccttgaag ccgcacgaca     4080

tggactccct gttagagaca taagaagaat tcgtaatagg aagacgtcag atgcaactct     4140

acctgccgga tccgatcgtt taaaccagct cgtgaaaagc gaactcgaag aaaagaaaag     4200

tgaactgcgg cacaaactga aatacgtccc acatgaatac attgagctga tcgagattgc     4260

taggaactcc acccaggaca gaatcctcga gatgaaagtg atggaattct ttatgaaagt     4320

ctacgggtat cggggcaagc acctgggcgg atctcgcaaa ccagatgggg caatctacac     4380

tgtgggtagt cccatcgact atggcgtgat tgtcgatacc aaggcctaca gtgggggtta     4440

taatctgccc attggacagg ctgacgagat gcagcgatac gtggaggaaa accagacaag     4500

aaataagcat atcaacccca atgagtggtg gaaagtgtat cctagctccg tcactgaatt     4560

caagtttctc ttcgtgtcag gccactttaa gggaaactac aaagcacagc tgaccaggct     4620

caatcatatt acaaactgca atggcgccgt gctgagcgtc gaggaactgc tcatcggcgg     4680

agagatgatc aaggccggca cactcaccct ggaggaggtc cgccgaaaat tcaataacgg     4740

ggaaatcaac ttctgaacgc gtaaatgatt gcagatccac tagttctaga attccagctg     4800

agcgccggtc gctaccatta ccagttggtc tggtgtcaaa aataataata accgggcagg     4860

ggggatctgc atggatcttt gtgaaggaac cttacttctg tggtgtgaca taattggaca     4920

aactacctac agagatttaa agctctaagg taaatataaa atttttaagt gtataatgtg     4980

ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga actgatgaat     5040

gggagcagtg gtggaatgcc agatccagac atgataagat acattgatga gtttggacaa     5100

accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct     5160

ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt     5220

atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa     5280

tgtggtatgg ctgattatga tctgcggccg ccactggccg tcgttttaca acgtcgtgac     5340

tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc     5400

tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat     5460

ggcgaatgga acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc     5520

agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc     5580

tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg     5640

ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca     5700

cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc     5760

tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct     5820

tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa     5880

caaaaattta acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc     5940

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     6000

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     6060

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     6120

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     6180

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     6240

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     6300

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     6360

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     6420

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     6480

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     6540

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     6600

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     6660

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     6720

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     6780

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     6840

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     6900

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     6960

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     7020

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     7080

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     7140

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7200

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7260

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     7320

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     7380

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     7440

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     7500

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     7560

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     7620

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7680

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     7740

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     7800

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     7860

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     7920

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     7980

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     8040

tgagcggata acaatttcac acaggaaaca gctatgacca tga                       8083


<210>  18
<211>  1007
<212>  PRT
<213>  Artificial sequence

<220>
<223>  YP-RALEN-RabA-Fok

<400>  18

Met Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Val Pro 
            20                  25                  30          


Met Ala Ala Leu Gly Tyr Ser Arg Glu Gln Ile Arg Lys Leu Lys Gln 
        35                  40                  45              


Glu Ser Leu Ser Gly Val Ala Lys Tyr His Ala Pro Leu Thr Arg His 
    50                  55                  60                  


Gly Phe Thr His Thr Asp Ile Cys Arg Ile Ser Arg Arg Trp Gln Ser 
65                  70                  75                  80  


Leu Arg Met Val Ala Lys Asn Tyr Pro Lys Leu Ile Ala Ala Leu Pro 
                85                  90                  95      


Asp Leu Thr Arg Thr His Ile Val Asp Ile Ala Arg Gln Arg Ser Gly 
            100                 105                 110         


Asp Leu Ala Leu Glu Ala Leu Leu Pro Val Ala Thr Ala Leu Ala Ala 
        115                 120                 125             


Ala Pro Leu Arg Leu Arg Ala Ser Gln Ile Ala Ile Ile Ala Gln Cys 
    130                 135                 140                 


Gly Glu Arg Pro Ala Ile Leu Ala Leu His Arg Leu Arg Arg Lys Leu 
145                 150                 155                 160 


Thr Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
                165                 170                 175     


Ala Asn Thr Gly Gly Lys Gln Ala Leu Gly Ala Ile Thr Thr Gln Leu 
            180                 185                 190         


Pro Ile Leu Arg Ala Ala Pro Tyr Glu Leu Ser Pro Glu Gln Val Val 
        195                 200                 205             


Ala Ile Ala Ser Asn Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys 
    210                 215                 220                 


Ala Gln Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu 
225                 230                 235                 240 


Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu 
                245                 250                 255     


Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu 
            260                 265                 270         


Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys Pro 
        275                 280                 285             


Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro 
    290                 295                 300                 


Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asp Gly 
305                 310                 315                 320 


Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg 
                325                 330                 335     


Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser 
            340                 345                 350         


His Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu 
        355                 360                 365             


Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala 
    370                 375                 380                 


Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala 
385                 390                 395                 400 


Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln 
                405                 410                 415     


Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala 
            420                 425                 430         


Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser 
        435                 440                 445             


Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asp Gly Gly Lys Pro Ala 
    450                 455                 460                 


Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr 
465                 470                 475                 480 


Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly 
                485                 490                 495     


Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala 
            500                 505                 510         


Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu 
    530                 535                 540                 


Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile 
545                 550                 555                 560 


Ala Ser Asn Thr Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu 
                565                 570                 575     


Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val 
            580                 585                 590         


Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala Val 
        595                 600                 605             


Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr 
    610                 615                 620                 


Glu Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys Pro Ala Leu 
625                 630                 635                 640 


Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu 
                645                 650                 655     


Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys 
            660                 665                 670         


Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Thr 
    690                 695                 700                 


Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu 
705                 710                 715                 720 


Arg Ala Ala Pro Tyr Glu Leu Ser Thr Thr Arg Val Val Ser Ile Ala 
                725                 730                 735     


Cys Ile Gly Gly Arg Gln Ala Leu Glu Ala Ile Lys Thr His Met Pro 
            740                 745                 750         


Ala Leu Arg Gln Ala Pro Tyr Ser Leu Ser His Glu Arg Val Val Ala 
        755                 760                 765             


Ile Val Cys Asn Gly Gly Arg Ser Ala Leu Glu Ala Ala Arg His Gly 
    770                 775                 780                 


Leu Pro Val Arg Asp Ile Arg Arg Ile Arg Asn Arg Lys Thr Ser Asp 
785                 790                 795                 800 


Ala Thr Leu Pro Ala Gly Ser Asp Arg Leu Asn Gln Leu Val Lys Ser 
                805                 810                 815     


Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val 
            820                 825                 830         


Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln 
        835                 840                 845             


Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr 
    850                 855                 860                 


Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala 
865                 870                 875                 880 


Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr 
                885                 890                 895     


Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu 
            900                 905                 910         


Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn 
        915                 920                 925             


Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys 
    930                 935                 940                 


Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu 
945                 950                 955                 960 


Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val 
                965                 970                 975     


Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr 
            980                 985                 990         


Leu Glu Glu Val Arg Arg Lys Phe  Asn Asn Gly Glu Ile  Asn Phe 
        995                 1000                 1005         


<210>  19
<211>  1007
<212>  PRT
<213>  Artificial sequence

<220>
<223>  YP-Ralen-RabB-Fok

<400>  19

Met Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Val Pro 
            20                  25                  30          


Met Ala Ala Leu Gly Tyr Ser Arg Glu Gln Ile Arg Lys Leu Lys Gln 
        35                  40                  45              


Glu Ser Leu Ser Gly Val Ala Lys Tyr His Ala Pro Leu Thr Arg His 
    50                  55                  60                  


Gly Phe Thr His Thr Asp Ile Cys Arg Ile Ser Arg Arg Trp Gln Ser 
65                  70                  75                  80  


Leu Arg Met Val Ala Lys Asn Tyr Pro Lys Leu Ile Ala Ala Leu Pro 
                85                  90                  95      


Asp Leu Thr Arg Thr His Ile Val Asp Ile Ala Arg Gln Arg Ser Gly 
            100                 105                 110         


Asp Leu Ala Leu Glu Ala Leu Leu Pro Val Ala Thr Ala Leu Ala Ala 
        115                 120                 125             


Ala Pro Leu Arg Leu Arg Ala Ser Gln Ile Ala Ile Ile Ala Gln Cys 
    130                 135                 140                 


Gly Glu Arg Pro Ala Ile Leu Ala Leu His Arg Leu Arg Arg Lys Leu 
145                 150                 155                 160 


Thr Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
                165                 170                 175     


Ala Asn Thr Gly Gly Lys Gln Ala Leu Gly Ala Ile Thr Thr Gln Leu 
            180                 185                 190         


Pro Ile Leu Arg Ala Ala Pro Tyr Glu Leu Ser Pro Glu Gln Val Val 
        195                 200                 205             


Ala Ile Ala Ser Asn Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys 
    210                 215                 220                 


Ala Gln Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu 
225                 230                 235                 240 


Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu 
                245                 250                 255     


Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu 
            260                 265                 270         


Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro 
        275                 280                 285             


Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro 
    290                 295                 300                 


Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asp Gly 
305                 310                 315                 320 


Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg 
                325                 330                 335     


Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser 
            340                 345                 350         


Asn Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu 
        355                 360                 365             


Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala 
    370                 375                 380                 


Ile Ala Ser Asn Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala 
385                 390                 395                 400 


Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln 
                405                 410                 415     


Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala 
            420                 425                 430         


Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser 
        435                 440                 445             


Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala 
    450                 455                 460                 


Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr 
465                 470                 475                 480 


Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly 
                485                 490                 495     


Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala 
            500                 505                 510         


Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His 
        515                 520                 525             


Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu 
    530                 535                 540                 


Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile 
545                 550                 555                 560 


Ala Ser His Asn Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu 
                565                 570                 575     


Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val 
            580                 585                 590         


Val Ala Ile Ala Ser Asn Thr Gly Gly Lys Pro Ala Leu Glu Ala Val 
        595                 600                 605             


Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr 
    610                 615                 620                 


Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Pro Ala Leu 
625                 630                 635                 640 


Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu 
                645                 650                 655     


Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asp Gly Gly Lys 
            660                 665                 670         


Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn 
    690                 695                 700                 


Gly Gly Lys Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu 
705                 710                 715                 720 


Arg Ala Ala Pro Tyr Glu Leu Ser Thr Thr Arg Val Val Ser Ile Ala 
                725                 730                 735     


Cys Ile Gly Gly Arg Gln Ala Leu Glu Ala Ile Lys Thr His Met Pro 
            740                 745                 750         


Ala Leu Arg Gln Ala Pro Tyr Ser Leu Ser His Glu Arg Val Val Ala 
        755                 760                 765             


Ile Val Cys Asn Gly Gly Arg Ser Ala Leu Glu Ala Ala Arg His Gly 
    770                 775                 780                 


Leu Pro Val Arg Asp Ile Arg Arg Ile Arg Asn Arg Lys Thr Ser Asp 
785                 790                 795                 800 


Ala Thr Leu Pro Ala Gly Ser Asp Arg Leu Asn Gln Leu Val Lys Ser 
                805                 810                 815     


Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val 
            820                 825                 830         


Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln 
        835                 840                 845             


Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr 
    850                 855                 860                 


Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala 
865                 870                 875                 880 


Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr 
                885                 890                 895     


Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu 
            900                 905                 910         


Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn 
        915                 920                 925             


Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys 
    930                 935                 940                 


Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu 
945                 950                 955                 960 


Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val 
                965                 970                 975     


Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr 
            980                 985                 990         


Leu Glu Glu Val Arg Arg Lys Phe  Asn Asn Gly Glu Ile  Asn Phe 
        995                 1000                 1005         


<210>  20
<211>  7386
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRALEN-Rep-Rab

<400>  20
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccggactct      600

agaggatccg gtactcgagg acactgcaga gacctacttc actaacaacc ggtatggtcg      660

cgagtagctt ggcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta      720

cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg      780

cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg cgctttgcct      840

ggtttccggc accagaagcg gtgccggaaa gctggctgga gtgcgatctt cctgaggccg      900

atactgtcgt cgtcccctca aactggcaga tgcacggtta cgatgcgccc atctacacca      960

acgtgaccta tcccattacg gtcaatccgc cgtttgttcc cacggagaat ccgacgggtt     1020

gttactcgct cacatttaat gttgatgaaa gctggctata aaaccggtac agttcggcca     1080

ccatggtcgt atcaagcgct atgtgtttca cactcttcta tcgcactacc gggccatggg     1140

gtcgcgagta gcttggcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc     1200

gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa     1260

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggcgcttt     1320

gcctggtttc cggcaccaga agcggtgccg gaaagctggc tggagtgcga tcttcctgag     1380

gccgatactg tcgtcgtccc ctcaaactgg cagatgcacg gttacgatgc gcccatctac     1440

accaacgtga cctatcccat tacggtcaat ccgccgtttg ttcccacgga gaatccgacg     1500

ggttgttact cgctcacatt taatgttgat gaaagctggc tacaggaagg ccagacgcga     1560

attatttttg atggcgttaa ctcggcgttt catctgtggt gcaacgggcg ctgggtcggt     1620

tacggccagg acagtcgttt gccgtctgaa tttgacctga gcgcattttt acgcgccgga     1680

gaaaaccgcc tcgcggtgat ggtgctgcgc tggagtgacg gcagttatct ggaagatcag     1740

gatatgtggc ggatgagcgg cattttccgt gacgtctcgt tgctgcataa accgactaca     1800

caaatcagcg atttccatgt tgccactcgc tttaatgatg atttcagccg cgctgtactg     1860

gaggctgaag ttcagatgtg cggcgagttg cgtgactacc tacgggtaac agtttcttta     1920

tggcagggtg aaacgcaggt cgccagcggc accgcgcctt tcggcggtga aattatcgat     1980

gagcgtggtg gttatgccga tcgcgtcaca ctacgtctga acgtcgaaaa cccgaaactg     2040

tggagcgccg aaatcccgaa tctctatcgt gcggtggttg aactgcacac cgccgacggc     2100

acgctgattg aagcagaagc ctgcgatgtc ggtttccgcg aggtgcggat tgaaaatggt     2160

ctgctgctgc tgaacggcaa gccgttgctg attcgaggcg ttaaccgtca cgagcatcat     2220

cctctgcatg gtcaggtcat ggatgagcag acgatggtgc aggatatcct gctgatgaag     2280

cagaacaact ttaacgccgt gcgctgttcg cattatccga accatccgct gtggtacacg     2340

ctgtgcgacc gctacggcct gtatgtggtg gatgaagcca atattgaaac ccacggcatg     2400

gtgccaatga atcgtctgac cgatgatccg cgctggctac cggcgatgag cgaacgcgta     2460

acgcgaatgg tgcagcgcga tcgtaatcac ccgagtgtga tcatctggtc gctggggaat     2520

gaatcaggcc acggcgctaa tcacgacgcg ctgtatcgct ggatcaaatc tgtcgatcct     2580

tcccgcccgg tgcagtatga aggcggcgga gccgacacca cggccaccga tattatttgc     2640

ccgatgtacg cgcgcgtgga tgaagaccag cccttcccgg ctgtgccgaa atggtccatc     2700

aaaaaatggc tttcgctacc tggagagacg cgcccgctga tcctttgcga atacgcccac     2760

gcgatgggta acagtcttgg cggtttcgct aaatactggc aggcgtttcg tcagtatccc     2820

cgtttacagg gcggcttcgt ctgggactgg gtggatcagt cgctgattaa atatgatgaa     2880

aacggcaacc cgtggtcggc ttacggcggt gattttggcg atacgccgaa cgatcgccag     2940

ttctgtatga acggtctggt ctttgccgac cgcacgccgc atccagcgct gacggaagca     3000

aaacaccagc agcagttttt ccagttccgt ttatccgggc aaaccatcga agtgaccagc     3060

gaatacctgt tccgtcatag cgataacgag ctcctgcact ggatggtggc gctggatggt     3120

aagccgctgg caagcggtga agtgcctctg gatgtcgctc cacaaggtaa acagttgatt     3180

gaactgcctg aactaccgca gccggagagc gccgggcaac tctggctcac agtacgcgta     3240

gtgcaaccga acgcgaccgc atggtcagaa gccgggcaca tcagcgcctg gcagcagtgg     3300

cgtctggcgg aaaacctcag tgtgacgctc cccgccgcgt cccacgccat cccgcatctg     3360

accaccagcg aaatggattt ttgcatcgag ctgggtaata agcgttggca atttaaccgc     3420

cagtcaggct ttctttcaca gatgtggatt ggcgataaaa aacaactgct gacgccgctg     3480

cgcgatcagt tcacccgtgc accgctggat aacgacattg gcgtaagtga agcgacccgc     3540

attgacccta acgcctgggt cgaacgctgg aaggcggcgg gccattacca ggccgaagca     3600

gcgttgttgc agtgcacggc agatacactt gctgatgcgg tgctgattac gaccgctcac     3660

gcgtggcagc atcaggggaa aaccttattt atcagccgga aaacctaccg gattgatggt     3720

agtggtcaaa tggcgattac cgttgatgtt gaagtggcga gcgatacacc gcatccggcg     3780

cggattggcc tgaactgcca gctggcgcag gtagcagagc gggtaaactg gctcggatta     3840

gggccgcaag aaaactatcc cgaccgcctt actgccgcct gttttgaccg ctgggatctg     3900

ccattgtcag acatgtatac cccgtacgtc ttcccgagcg aaaacggtct gcgctgcggg     3960

acgcgcgaat tgaattatgg cccacaccag tggcgcggcg acttccagtt caacatcagc     4020

cgctacagtc aacagcaact gatggaaacc agccatcgcc atctgctgca cgcggaagaa     4080

ggcacatggc tgaatatcga cggtttccat atggggattg gtggcgacga ctcctggagc     4140

ccgtcagtat cggcggaatt acagctgagc gccggtcgct accattacca gttggtctgg     4200

tgtcaaaaat aataataacc gggcaggcca tgtctgcccg tatttcgcgt aaggaaatcc     4260

attatgtact atttaaaaaa cacaaacttt tggatgttcg gtttattctt tttcttttac     4320

ttttttatca tgggagccta cttcccgttt ttcccgattt ggctacatga catcaaccat     4380

atcagcaaaa gtgatacggg tattattttt gccgctattt ctctgttctc gctattattc     4440

caaccgctgt ttggtctgct ttctgacaaa ctcggcctcg actctaggcg gccgcgggga     4500

tccagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa     4560

aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg     4620

caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt     4680

gtgggaggtt ttttcggatc ctctagagtc gacctgcagg catgcaagct tggcgtaatc     4740

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     4800

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     4860

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     4920

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     4980

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     5040

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     5100

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     5160

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     5220

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     5280

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     5340

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     5400

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     5460

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     5520

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     5580

tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     5640

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     5700

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     5760

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     5820

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     5880

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     5940

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     6000

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     6060

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     6120

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     6180

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     6240

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     6300

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     6360

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     6420

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     6480

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     6540

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     6600

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     6660

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     6720

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     6780

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     6840

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt     6900

ctaagaaacc attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt     6960

tcgtctcgcg cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac     7020

ggtcacagct tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc     7080

gggtgttggc gggtgtcggg gctggcttaa ctatgcggca tcagagcaga ttgtactgag     7140

agtgcaccat atgcggtgtg aaataccgca cagatgcgta aggagaaaat accgcatcag     7200

gcgccattcg ccattcaggc tgcgcaactg ttgggaaggg cgatcggtgc gggcctcttc     7260

gctattacgc cagctggcga aagggggatg tgctgcaagg cgattaagtt gggtaacgcc     7320

agggttttcc cagtcacgac gttgtaaaac gacggccagt gaattcgagc ttgcatgcct     7380

gcaggt                                                                7386


<210>  21
<211>  196
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FokI nuclease domain

<400>  21

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer Rab-for

<400>  22
ggcctccagg atgcagacac c                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer Rab-rev

<400>  23
ccagcaatgt cccagagctg c                                                 21


<210>  24
<211>  202
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mouse Rab38 gene exon 1

<400>  24
atgcagacac ctcacaagga gcacctgtac aagctgctgg tgatcggcga cctgggtgtg       60

ggcaagacca gcattatcaa gcgctatgtg caccaaaact tctcctcgca ctaccgggcc      120

accattggtg tggacttcgc gctgaaggtg ctccactggg acccagagac ggtggtgcgc      180

ttgcagctct gggacattgc tg                                               202


<210>  25
<211>  1241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein RSc1815 from Ralstonia solanacearum

<400>  25

Lys Ser Ser Gly Trp Leu Asn Glu Ser Val Ser Leu Glu Tyr Glu His 
1               5                   10                  15      


Val Ser Pro Pro Thr Arg Pro Arg Asp Thr Arg Arg Arg Pro Arg Ala 
            20                  25                  30          


Ala Gly Asp Gly Gly Leu Ala His Leu His Arg Arg Leu Ala Val Gly 
        35                  40                  45              


Tyr Ala Glu Asp Thr Pro Arg Thr Glu Ala Arg Ser Pro Ala Pro Arg 
    50                  55                  60                  


Arg Pro Leu Pro Val Ala Pro Ala Ser Ala Pro Pro Ala Pro Ser Leu 
65                  70                  75                  80  


Val Pro Glu Pro Pro Met Pro Val Ser Leu Pro Ala Val Ser Ser Pro 
                85                  90                  95      


Arg Phe Ser Ala Gly Ser Ser Ala Ala Ile Thr Asp Pro Phe Pro Ser 
            100                 105                 110         


Leu Pro Pro Thr Pro Val Leu Tyr Ala Met Ala Arg Glu Leu Glu Ala 
        115                 120                 125             


Leu Ser Asp Ala Thr Trp Gln Pro Ala Val Pro Leu Pro Ala Glu Pro 
    130                 135                 140                 


Pro Thr Asp Ala Arg Arg Gly Asn Thr Val Phe Asp Glu Ala Ser Ala 
145                 150                 155                 160 


Ser Ser Pro Val Ile Ala Ser Ala Cys Pro Gln Ala Phe Ala Ser Pro 
                165                 170                 175     


Pro Arg Ala Pro Arg Ser Ala Arg Ala Arg Arg Ala Arg Thr Gly Gly 
            180                 185                 190         


Asp Ala Trp Pro Ala Pro Thr Phe Leu Ser Arg Pro Ser Ser Ser Arg 
        195                 200                 205             


Ile Gly Arg Asp Val Phe Gly Lys Leu Val Ala Leu Gly Tyr Ser Arg 
    210                 215                 220                 


Glu Gln Ile Arg Lys Leu Lys Gln Glu Ser Leu Ser Glu Ile Ala Lys 
225                 230                 235                 240 


Tyr His Thr Thr Leu Thr Gly Gln Gly Phe Thr His Ala Asp Ile Cys 
                245                 250                 255     


Arg Ile Ser Arg Arg Arg Gln Ser Leu Arg Val Val Ala Arg Asn Tyr 
            260                 265                 270         


Pro Glu Leu Ala Ala Ala Leu Pro Glu Leu Thr Arg Ala His Ile Val 
        275                 280                 285             


Asp Ile Ala Arg Gln Arg Ser Gly Asp Leu Ala Leu Gln Ala Leu Leu 
    290                 295                 300                 


Pro Val Ala Thr Ala Leu Thr Ala Ala Pro Leu Arg Leu Ser Ala Ser 
305                 310                 315                 320 


Gln Ile Ala Thr Val Ala Gln Tyr Gly Glu Arg Pro Ala Ile Gln Ala 
                325                 330                 335     


Leu Tyr Arg Leu Arg Arg Lys Leu Thr Arg Ala Pro Leu His Leu Thr 
            340                 345                 350         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys Arg Ala 
        355                 360                 365             


Leu Glu Ala Val Cys Val Gln Leu Pro Val Leu Arg Ala Ala Pro Tyr 
    370                 375                 380                 


Arg Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Lys Gly Gly 
385                 390                 395                 400 


Lys Gln Ala Leu Glu Ala Val Lys Ala His Leu Leu Asp Leu Leu Gly 
                405                 410                 415     


Ala Pro Tyr Val Leu Asp Thr Glu Gln Val Val Ala Ile Ala Ser His 
            420                 425                 430         


Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp Leu Leu Asp 
        435                 440                 445             


Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp 
465                 470                 475                 480 


Leu Leu Glu Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val 
                485                 490                 495     


Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val 
            500                 505                 510         


Lys Ala His Leu Leu Asp Leu Arg Gly Val Pro Tyr Ala Leu Ser Thr 
        515                 520                 525             


Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu 
    530                 535                 540                 


Glu Ala Val Lys Ala Gln Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala 
545                 550                 555                 560 


Leu Ser Thr Ala Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
                565                 570                 575     


Gln Ala Leu Glu Gly Ile Gly Glu Gln Leu Leu Lys Leu Arg Thr Ala 
            580                 585                 590         


Pro Tyr Gly Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asp 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Ala Val Gly Ala Gln Leu Val Ala Leu 
    610                 615                 620                 


Arg Ala Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala 
625                 630                 635                 640 


Ser Asn Lys Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln Leu 
                645                 650                 655     


Leu Glu Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Ala Gln Val Val 
            660                 665                 670         


Ala Ile Ala Ser His Asp Gly Gly Asn Gln Ala Leu Glu Ala Val Gly 
        675                 680                 685             


Thr Gln Leu Val Ala Leu Arg Ala Ala Pro Tyr Ala Leu Ser Thr Glu 
    690                 695                 700                 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
705                 710                 715                 720 


Ala Val Gly Ala Gln Leu Val Ala Leu Arg Ala Ala Pro Tyr Ala Leu 
                725                 730                 735     


Asn Thr Glu Gln Val Val Ala Ile Ala Ser Ser His Gly Gly Lys Gln 
            740                 745                 750         


Ala Leu Glu Ala Val Arg Ala Leu Phe Pro Asp Leu Arg Ala Ala Pro 
        755                 760                 765             


Tyr Ala Leu Ser Thr Ala Gln Leu Val Ala Ile Ala Ser Asn Pro Gly 
    770                 775                 780                 


Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Arg Glu Leu Arg 
785                 790                 795                 800 


Ala Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser 
                805                 810                 815     


Asn His Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Arg 
            820                 825                 830         


Gly Leu Arg Ala Ala Pro Tyr Gly Leu Ser Thr Ala Gln Val Val Ala 
        835                 840                 845             


Ile Ala Ser Ser Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Trp Ala 
    850                 855                 860                 


Leu Leu Pro Val Leu Arg Ala Thr Pro Tyr Asp Leu Asn Thr Ala Gln 
865                 870                 875                 880 


Ile Val Ala Ile Ala Ser His Asp Gly Gly Lys Pro Ala Leu Glu Ala 
                885                 890                 895     


Val Trp Ala Lys Leu Pro Val Leu Arg Gly Ala Pro Tyr Ala Leu Ser 
            900                 905                 910         


Thr Ala Gln Val Val Ala Ile Ala Cys Ile Ser Gly Gln Gln Ala Leu 
        915                 920                 925             


Glu Ala Ile Glu Ala His Met Pro Thr Leu Arg Gln Ala Ser His Ser 
    930                 935                 940                 


Leu Ser Pro Glu Arg Val Ala Ala Ile Ala Cys Asn Gly Gly Arg Ser 
945                 950                 955                 960 


Ala Val Glu Ala Val Arg Gln Gly Leu Pro Val Lys Ala Ile Arg Arg 
                965                 970                 975     


Ile Arg Arg Glu Lys Ala Pro Val Ala Gly Pro Pro Pro Ala Ser Leu 
            980                 985                 990         


Gly Pro Thr Pro Gln Glu Leu Val  Ala Val Leu His Phe  Phe Arg Ala 
        995                 1000                 1005             


His Gln  Gln Pro Arg Gln Ala  Phe Val Asp Ala Leu  Ala Ala Phe 
    1010                 1015                 1020             


Gln Ala  Thr Arg Pro Ala Leu  Leu Arg Leu Leu Ser  Ser Val Gly 
    1025                 1030                 1035             


Val Thr  Glu Ile Glu Ala Leu  Gly Gly Thr Ile Pro  Asp Ala Thr 
    1040                 1045                 1050             


Glu Arg  Trp Gln Arg Leu Leu  Gly Arg Leu Gly Phe  Arg Pro Ala 
    1055                 1060                 1065             


Thr Gly  Ala Ala Ala Pro Ser  Pro Asp Ser Leu Gln  Gly Phe Ala 
    1070                 1075                 1080             


Gln Ser  Leu Glu Arg Thr Leu  Gly Ser Pro Gly Met  Ala Gly Gln 
    1085                 1090                 1095             


Ser Ala  Cys Ser Pro His Arg  Lys Arg Pro Ala Glu  Thr Ala Ile 
    1100                 1105                 1110             


Ala Pro  Arg Ser Ile Arg Arg  Ser Pro Asn Asn Ala  Gly Gln Pro 
    1115                 1120                 1125             


Ser Glu  Pro Trp Pro Asp Gln  Leu Ala Trp Leu Gln  Arg Arg Lys 
    1130                 1135                 1140             


Arg Thr  Ala Arg Ser His Ile  Arg Ala Asp Ser Ala  Ala Ser Val 
    1145                 1150                 1155             


Pro Ala  Asn Leu His Leu Gly  Thr Arg Ala Gln Phe  Thr Pro Asp 
    1160                 1165                 1170             


Arg Leu  Arg Ala Glu Pro Gly  Pro Ile Met Gln Ala  His Thr Ser 
    1175                 1180                 1185             


Pro Ala  Ser Val Ser Phe Gly  Ser His Val Ala Phe  Glu Pro Gly 
    1190                 1195                 1200             


Leu Pro  Asp Pro Gly Thr Pro  Thr Ser Ala Asp Leu  Ala Ser Phe 
    1205                 1210                 1215             


Glu Ala  Glu Pro Phe Gly Val  Gly Pro Leu Asp Phe  His Leu Asp 
    1220                 1225                 1230             


Trp Leu  Leu Gln Ile Leu Glu  Thr 
    1235                 1240     


<210>  26
<211>  1164
<212>  PRT
<213>  Ralstonia solanacearum

<400>  26

Met Arg Arg Arg Thr Ala Val Gly Arg Val Pro Gly Ala Ser Arg Ser 
1               5                   10                  15      


Gly Thr Ser Pro Leu Val Leu Ser Gln Pro Leu Ser Arg Val Ser Ala 
            20                  25                  30          


Ser Pro Gln Pro Ala Arg Ser Ser Ala Ile Ser Ser Pro Asn Phe Ser 
        35                  40                  45              


Ala Gly Asn Pro Thr Ala Phe Ala Asn Pro Ser Pro Ser Leu Pro Pro 
    50                  55                  60                  


Thr Pro Val Leu Pro Pro Thr Pro Val Leu Tyr Ala Met Ala Arg Glu 
65                  70                  75                  80  


Leu Glu Glu Leu His Asn Ala Thr Trp Gln Pro Ala Val Pro Leu Thr 
                85                  90                  95      


Ala Glu Pro Leu Ala Asp Ala Arg Arg Asp Asn Thr Val Val Asp Gly 
            100                 105                 110         


Gly Ser Gly Ser Ser Pro Ala Ile Ala Ser Ala Arg Pro Gln Ala Phe 
        115                 120                 125             


Ala Gly Pro Pro Arg Ala Pro Arg Ser Ala Arg Ala Arg Arg Ala Arg 
    130                 135                 140                 


Thr Ala Gly Asp Ala Trp Pro Ala Pro Ala Tyr Leu Gly Pro Ser Pro 
145                 150                 155                 160 


Ser Pro Ser Pro Ser Pro Ser Pro Ser Pro Arg Ile Ala Pro Asp Leu 
                165                 170                 175     


Ser Gly Lys Leu Ala Ala Leu Gly Tyr Ser Arg Glu Gln Ile Arg Lys 
            180                 185                 190         


Leu Lys Gln Glu Ser Leu Ala Glu Val Ala Lys Tyr His Ala Thr Leu 
        195                 200                 205             


Ala Gly Gln Gly Phe Thr His Ala Asp Ile Cys Arg Ile Ser Arg Arg 
    210                 215                 220                 


Trp Gln Ser Leu Arg Val Val Ala Asn Asn Tyr Pro Glu Leu Met Ala 
225                 230                 235                 240 


Ala Leu Pro Arg Leu Thr Thr Ala Gln Ile Val Asp Ile Ala Arg Gln 
                245                 250                 255     


Arg Ser Gly Asp Leu Ala Leu Gln Ala Leu Leu Pro Val Ala Ala Ala 
            260                 265                 270         


Leu Thr Ala Ala Pro Leu Gly Leu Ser Ala Ser Gln Ile Ala Thr Val 
        275                 280                 285             


Ala Gln Tyr Gly Glu Arg Pro Ala Ile Gln Ala Leu Tyr Arg Leu Arg 
    290                 295                 300                 


Arg Lys Leu Thr Arg Ala Pro Leu Gly Leu Thr Pro Gln Gln Val Val 
305                 310                 315                 320 


Ala Ile Ala Ser Asn Thr Gly Gly Lys Gln Ala Leu Glu Ala Val Thr 
                325                 330                 335     


Val Gln Leu Arg Val Leu Arg Gly Ala Arg Tyr Gly Leu Ser Thr Glu 
            340                 345                 350         


Gln Val Val Ala Val Ala Ser Asn Lys Gly Gly Lys Gln Ala Leu Ala 
        355                 360                 365             


Ala Val Glu Ala Gln Leu Leu Arg Leu Arg Ala Ala Pro Tyr Glu Leu 
    370                 375                 380                 


Ser Thr Glu Gln Val Val Ala Val Ala Ser His Asn Gly Gly Lys Gln 
385                 390                 395                 400 


Ala Leu Glu Ala Val Arg Ala Gln Leu Leu Asp Leu Arg Ala Ala Pro 
                405                 410                 415     


Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly 
            420                 425                 430         


Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Gln Leu Pro Ala Leu Arg 
        435                 440                 445             


Ala Ala Pro Tyr Gly Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser 
    450                 455                 460                 


His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln Leu Pro 
465                 470                 475                 480 


Val Leu Arg Arg Ala Pro Tyr Gly Leu Ser Thr Glu Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Gly Ile Gly Lys 
            500                 505                 510         


Gln Leu Gln Glu Leu Arg Ala Ala Pro His Gly Leu Ser Thr Ala Gln 
        515                 520                 525             


Val Ala Thr Ile Ala Ser Ser Ile Gly Gly Arg Gln Ala Leu Glu Ala 
    530                 535                 540                 


Val Lys Val Gln Leu Pro Val Leu Arg Ala Ala Pro Tyr Gly Leu Thr 
545                 550                 555                 560 


Ile Ala Gln Val Val Ala Val Ala Ser His Asn Gly Gly Lys Gln Ala 
                565                 570                 575     


Leu Glu Ala Ile Gly Ala Gln Leu Leu Ala Leu Arg Ala Ala Pro Tyr 
            580                 585                 590         


Ala Leu Ser Thr Ala Gln Val Val Ala Ile Ala Ser Asn Asp Gly Gly 
        595                 600                 605             


Lys Gln Ala Leu Glu Glu Val Glu Ala Gln Leu Leu Ala Leu Arg Ala 
    610                 615                 620                 


Ala Pro Tyr Glu Leu Ser Ser Ala Gln Val Ile Ala Ile Ala Ala Gly 
625                 630                 635                 640 


Asn Asp Gly Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln Leu 
                645                 650                 655     


Pro Val Leu Arg Ala Ala Pro Tyr Glu Leu Ser Val Ala Gln Val Val 
            660                 665                 670         


Thr Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Arg 
        675                 680                 685             


Ala Gln Leu Leu Ala Leu Arg Ala Ala Pro Tyr Gly Leu Ser Thr Ala 
    690                 695                 700                 


Gln Val Val Ala Val Ala Gly Arg Asn Gly Gly Lys Gln Ala Leu Glu 
705                 710                 715                 720 


Ala Val Arg Ala Gln Leu Pro Ala Leu Arg Ala Ala Pro Tyr Gly Leu 
                725                 730                 735     


Ser Ile Ala Gln Val Val Ala Val Ala Ser Arg Ser Gly Gly Lys Gln 
            740                 745                 750         


Ala Leu Glu Ala Val Arg Ala Gln Leu Leu Ala Leu Arg Ala Ala Pro 
        755                 760                 765             


Tyr Gly Leu Ser Thr Ala Gln Val Val Ala Val Ala Ser Gly Ser Gly 
    770                 775                 780                 


Gly Lys Pro Ala Leu Glu Ala Val Arg Ala Gln Leu Leu Ala Leu Arg 
785                 790                 795                 800 


Ala Ala Pro Tyr Gly Leu Ser Thr Ala Gln Val Val Ala Val Ala Ser 
                805                 810                 815     


His Asp Gly Gly Lys Pro Ala Leu Glu Ala Val Arg Lys Gln Leu Pro 
            820                 825                 830         


Val Leu Arg Gly Val Pro His Gln Leu Ser Ile Ala Gln Val Ile Ala 
        835                 840                 845             


Ile Ala Cys Ile Gly Gly Arg Gln Ala Leu Thr Ala Ile Glu Met His 
    850                 855                 860                 


Met Leu Ala Leu Arg Ala Ala Pro Tyr Asn Leu Ser Pro Glu Arg Val 
865                 870                 875                 880 


Val Ala Ile Val Cys Ile Gly Gly Arg Ser Ala Val Glu Ala Ile Arg 
                885                 890                 895     


His Gly Leu Pro Val Lys Arg Ile Gln Arg Ile Arg Arg Arg Lys Ala 
            900                 905                 910         


Pro Glu Ala Thr Pro Pro Ala Gly Pro Phe Gly Pro Thr Pro Gln Glu 
        915                 920                 925             


Leu Val Ala Val Leu His Phe Phe Arg Ala His Arg Gln Pro Arg His 
    930                 935                 940                 


Ala Phe Val Asp Ala Leu Thr Glu Phe Gln Ile Thr Arg Ala Ala Leu 
945                 950                 955                 960 


Leu Arg Leu Leu Ser Ser Ala Gly Val Thr Glu Ile Glu Ala Leu Gly 
                965                 970                 975     


Gly Thr Ile Pro Asp Ala Ala Glu Arg Trp Gln Arg Leu Leu Gly Arg 
            980                 985                 990         


Leu Gly Thr Arg Gln Ala Ile Gly  Val Ala Ala Pro Ser  Pro Asp Ser 
        995                 1000                 1005             


Leu Gln  Gly Phe Ala Gln Ser  Leu Glu Arg Ser Met  Leu Ser Pro 
    1010                 1015                 1020             


Gly Ile  Ala Glu Gln Ser Ala  Ser Pro Pro Pro Arg  Glu Arg Pro 
    1025                 1030                 1035             


Ala Glu  Thr Ala Ile Ala Pro  Arg Ser Asn Thr Gly  Arg Pro Ser 
    1040                 1045                 1050             


Glu Pro  Trp Leu Asp Gln Pro  Ala Trp Ser Gln His  Arg Lys Arg 
    1055                 1060                 1065             


Thr Val  Arg Ser Arg Met Arg  Ala Asp Ala Val Ala  Asn Met Pro 
    1070                 1075                 1080             


Ala Asn  Pro His Arg Asp Ala  Arg Ala Gln Phe Thr  Pro Gly Cys 
    1085                 1090                 1095             


Leu Pro  Pro Ala Pro Gly Pro  Met Pro Ala His Ile  Ser Pro Ala 
    1100                 1105                 1110             


Ser Ala  Gly Ser Ser Ser His  Val Ala Ser Gly Ser  Val Leu Pro 
    1115                 1120                 1125             


Asp Pro  Gly Thr Pro Thr Gly  Ser Asp Leu Ala Met  Leu Glu Ala 
    1130                 1135                 1140             


Glu Ser  Phe Gly Ala Ala Ala  Leu Ala Phe Asp Phe  Asp Ser Phe 
    1145                 1150                 1155             


Leu Gln  Met Leu Asp Val 
    1160                 


<210>  27
<211>  1178
<212>  PRT
<213>  Ralstonia solanacearum

<400>  27

Met Arg Val Gly Lys Ala Arg Glu Arg Thr Ser Glu Ser Leu Pro Pro 
1               5                   10                  15      


Glu Arg Asp Glu His Val Ser Gln Ala Thr Thr Gln Leu Gly Glu Ser 
            20                  25                  30          


Arg Arg Arg Pro Arg Ala Ala Ser Asp Asp Gly Leu Ala Arg Leu Arg 
        35                  40                  45              


Arg Arg Thr Ala Ser Gly His Met Pro Gly Ala Ser Arg Thr Thr Ala 
    50                  55                  60                  


Gln Ser Thr Ala Pro His Leu Pro Arg Pro Ala Ala Ser Pro Ser Pro 
65                  70                  75                  80  


Gln Leu Ala Arg Pro Ser Val Ser Gly Leu Ala Met Pro Thr Ser Leu 
                85                  90                  95      


Pro Ala Val Ser Ser Pro His Leu Pro Ala Gly Ser Ala Ala Pro Gly 
            100                 105                 110         


Arg Pro Val Phe Ala Met Ala Arg Pro Gln Ala Phe Ala Ser Pro Pro 
        115                 120                 125             


Arg Ala Pro Arg Ser Thr Leu Pro Arg Arg Ala Arg Thr Ala Gly Asp 
    130                 135                 140                 


Ala Trp Pro Ala Arg Thr Leu Pro Gly Phe Ala Pro Pro Leu Arg Ile 
145                 150                 155                 160 


Ala Arg Asp Leu Ser Gly Arg Leu Ala Ala Leu Gly Tyr Ser Arg Glu 
                165                 170                 175     


Gln Ile Arg Lys Leu Lys Gln Glu Ser Leu Ser Gly Val Ala Lys Tyr 
            180                 185                 190         


His Ala Pro Leu Thr Arg His Gly Phe Thr His Thr Asp Ile Cys Arg 
        195                 200                 205             


Ile Ser Arg Arg Trp Gln Ser Leu Arg Met Val Ala Lys Asn Tyr Pro 
    210                 215                 220                 


Lys Leu Ile Ala Ala Leu Pro Asp Leu Thr Arg Thr His Ile Val Asp 
225                 230                 235                 240 


Ile Ala Arg Gln Arg Ser Gly Asp Leu Ala Leu Glu Ala Leu Leu Pro 
                245                 250                 255     


Val Ala Thr Ala Leu Ala Ala Ala Pro Leu Arg Leu Arg Ala Ser Gln 
            260                 265                 270         


Ile Ala Ile Ile Ala Gln Cys Gly Glu Arg Pro Ala Ile Leu Ala Leu 
        275                 280                 285             


His Arg Leu Arg Arg Lys Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro 
    290                 295                 300                 


Gln Gln Val Val Ala Ile Ala Ala Asn Thr Gly Gly Lys Gln Ala Leu 
305                 310                 315                 320 


Gly Ala Ile Thr Thr Gln Leu Pro Ile Leu Arg Ala Ala Pro Tyr Glu 
                325                 330                 335     


Leu Ser Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
            340                 345                 350         


Gln Ala Leu Glu Ala Val Lys Ala Gln Leu Leu Glu Leu Arg Ala Ala 
        355                 360                 365             


Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asn 
    370                 375                 380                 


Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln Leu Leu Glu Leu 
385                 390                 395                 400 


Arg Ala Ala Pro Tyr Glu Leu Ser Pro Glu Gln Val Val Ala Ile Ala 
                405                 410                 415     


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln Leu 
            420                 425                 430         


Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val 
        435                 440                 445             


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys 
    450                 455                 460                 


Ala Gln Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu Ser Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Ala Val Lys Ala Gln Leu Leu Glu Leu Arg Ala Ala Pro Tyr Glu Leu 
            500                 505                 510         


Ser Thr Glu Gln Val Val Val Ile Ala Ser Asn Asn Gly Gly Lys Gln 
        515                 520                 525             


Ala Leu Glu Ala Val Lys Ala Gln Leu Leu Ala Leu Arg Ala Ala Pro 
    530                 535                 540                 


Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
545                 550                 555                 560 


Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg 
                565                 570                 575     


Ala Ala Pro Tyr Glu Leu Ser Thr Gly Gln Val Val Ala Ile Ala Ser 
            580                 585                 590         


Asn Gly Gly Gly Arg Gln Ala Leu Glu Ala Val Arg Glu Gln Leu Leu 
        595                 600                 605             


Ala Leu Arg Ala Val Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Val 
    610                 615                 620                 


Ile Ala Asn Ser Ile Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Val 
625                 630                 635                 640 


Gln Leu Pro Val Leu Arg Ala Ala Pro Tyr Glu Leu Ser Thr Glu Gln 
                645                 650                 655     


Val Val Ala Val Ala Ser Asn Lys Gly Gly Lys Gln Val Leu Glu Ala 
            660                 665                 670         


Val Gly Ala Gln Leu Leu Ala Leu Arg Ala Val Pro Tyr Glu Leu Thr 
        675                 680                 685             


Thr Ala Gln Val Val Ala Ile Ala Ser Asn Asp Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Ala Val Gly Ala Gln Leu Leu Val Leu Arg Ala Val Pro Tyr 
705                 710                 715                 720 


Glu Leu Thr Thr Ala Gln Val Val Ala Ile Ala Ser Asn Asp Gly Gly 
                725                 730                 735     


Lys Gln Thr Leu Glu Val Ala Gly Ala Gln Leu Leu Ala Leu Arg Ala 
            740                 745                 750         


Val Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn 
        755                 760                 765             


Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Thr Gln Leu Leu Ala 
    770                 775                 780                 


Leu Arg Thr Ala Pro Tyr Glu Leu Ser Thr Glu Gln Val Val Ala Ile 
785                 790                 795                 800 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Gln 
                805                 810                 815     


Leu Pro Ala Leu Arg Ala Ala Pro Tyr Glu Leu Ser Pro Glu Gln Val 
            820                 825                 830         


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Ala Val 
        835                 840                 845             


Arg Ala Leu Leu Pro Val Leu Arg Val Ala Pro Tyr Glu Leu Ser Thr 
    850                 855                 860                 


Thr Arg Val Val Ser Ile Ala Cys Ile Gly Gly Arg Gln Ala Leu Lys 
865                 870                 875                 880 


Ala Ile Lys Thr His Met Pro Ala Leu Arg Gln Ala Pro Tyr Ser Leu 
                885                 890                 895     


Ser His Glu Arg Val Val Ala Ile Val Cys Ile Gly Gly Arg Ser Ala 
            900                 905                 910         


Leu Glu Ala Ala Arg His Gly Leu Pro Val Arg Asp Ile Arg Arg Ile 
        915                 920                 925             


Arg Asn Arg Lys Thr Ser Asp Ala Thr Leu Pro Ala Pro Val Leu Gly 
    930                 935                 940                 


Pro Thr Pro Gln Glu Leu Val Ala Val Leu His Phe Phe Arg Thr His 
945                 950                 955                 960 


Gln Gln Pro Arg Gln Ala Phe Val Asp Ala Leu Thr Ala Phe Gln Thr 
                965                 970                 975     


Thr Arg Arg Ala Leu Leu Arg Leu Leu Ser Ser Ala Gly Val Thr Glu 
            980                 985                 990         


Ile Glu Ala Leu Gly Gly Met Ile  Pro Asp Ala Ala Glu  Arg Trp Gln 
        995                 1000                 1005             


Arg Leu  Leu Gly Arg Leu Gly  Ile Arg Pro Ala Thr  Asp Thr Val 
    1010                 1015                 1020             


Val Thr  Ser Pro Asp Pro Met  Gln Gly Phe Ala Gln  Ser Leu Glu 
    1025                 1030                 1035             


Arg Ser  Leu Met Ser Ser Gly  Thr Thr Glu Gln Ser  Ala Ser Pro 
    1040                 1045                 1050             


Ser Gln  His Arg Arg Pro Ala  Gly Thr Ala Lys Thr  Pro Glu Ser 
    1055                 1060                 1065             


Ala Arg  His Arg Leu Asp Asn  Ala Ala Gln Pro Pro  Met Gln Trp 
    1070                 1075                 1080             


Pro Asp  Gln Leu Val Trp Ser  Gln Arg Arg Arg Cys  Thr Ala Ser 
    1085                 1090                 1095             


Ser Gln  Thr Pro Pro Pro Gly  Ala Ala Ser Val Pro  Ala Asn Leu 
    1100                 1105                 1110             


Gln Trp  Gly Ala Arg Ala Gln  Arg Thr Ser Ser Arg  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Arg Pro Met Pro Ala  Arg Val Val Pro Ala  Ser Ala Gln 
    1130                 1135                 1140             


Pro Ser  Pro Leu Gly Asp Leu  Glu Phe Gly Leu Pro  Asp Pro Gly 
    1145                 1150                 1155             


Thr Pro  Thr Ala Ala Asp Leu  Ala Leu Asp Leu Asp  Trp Leu Leu 
    1160                 1165                 1170             


Gln Leu  Leu Asp Leu 
    1175             


<210>  28
<211>  649
<212>  PRT
<213>  Ralstonia solanacearum

<220>
<221> variant
<222> 246
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 247
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 248
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 249
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 250
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 251
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 252
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 253
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 254
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 255
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 256
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 257
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 258
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 259
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 260
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 261
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 262
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 263
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 264
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 265
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 266
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 267
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 268
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 269
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 270
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 271
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 272
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 273
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 274
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 275
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 276
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 277
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 278
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 279
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 280
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 281
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 282
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 283
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 284
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 285
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 286
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 287
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 288
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 289
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 290
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 291
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 292
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 293
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 294
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 295
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 296
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 297
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 298
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 299
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 300
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 301
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 302
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 303
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 304
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 305
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 306
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 307
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 308
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 309
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 310
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 311
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 312
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 313
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 314
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 315
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 316
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 317
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 318
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 319
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 320
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 321
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 322
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 323
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 324
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 325
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 326
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 327
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 328
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 329
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 330
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 331
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 332
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 333
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 334
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 335
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 336
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 337
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 338
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 339
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 340
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 341
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 342
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 343
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 344
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 345
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 346
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 347
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 348
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 349
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 350
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 351
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 352
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 353
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 354
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 355
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 356
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 357
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 358
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 359
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 360
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 361
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 362
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 363
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 364
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 365
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 366
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 367
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 368
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 369
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 370
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 371
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 372
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 373
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 374
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 375
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 376
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 377
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 378
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 379
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 380
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 381
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 382
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 383
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 384
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"
<220>
<221> variant
<222> 385
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<400>  28

Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys 
1               5                   10                  15      


Arg Ala Leu Glu Ala Val Cys Val Gln Leu Pro Val Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Arg Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Lys 
        35                  40                  45              


Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala His Leu Leu Asp Leu 
    50                  55                  60                  


Leu Gly Ala Pro Tyr Val Leu Asp Thr Glu Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp Leu 
                85                  90                  95      


Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val 
            100                 105                 110         


Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys 
        115                 120                 125             


Ala Asp Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu 
    130                 135                 140                 


Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu 
145                 150                 155                 160 


Ala Val Lys Ala Gln Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu 
                165                 170                 175     


Ser Thr Ala Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln 
            180                 185                 190         


Ala Leu Glu Ala Val Lys Ala Gln Leu Leu Asp Leu Arg Gly Ala Pro 
        195                 200                 205             


Tyr Ala Leu Ser Thr Ala Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
    210                 215                 220                 


Gly Lys Gln Ala Leu Glu Gly Ile Gly Glu Gln Leu Leu Lys Leu Arg 
225                 230                 235                 240 


Thr Ala Pro Tyr Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Ser His Gly Gly 
385                 390                 395                 400 


Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Pro Asp Leu Arg Ala 
                405                 410                 415     


Ala Pro Tyr Ala Leu Ser Thr Ala Gln Leu Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Pro Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Arg Glu 
        435                 440                 445             


Leu Arg Ala Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu 
465                 470                 475                 480 


Phe Arg Glu Leu Arg Ala Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val 
                485                 490                 495     


Val Ala Ile Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Ala Val 
            500                 505                 510         


Arg Ala Leu Phe Arg Gly Leu Arg Ala Ala Pro Tyr Gly Leu Ser Thr 
        515                 520                 525             


Ala Gln Val Val Ala Ile Ala Ser Ser Asn Gly Gly Lys Gln Ala Leu 
    530                 535                 540                 


Glu Ala Val Trp Ala Leu Leu Pro Val Leu Arg Ala Thr Pro Tyr Asp 
545                 550                 555                 560 


Leu Asn Thr Ala Gln Val Val Ala Ile Ala Ser His Tyr Gly Gly Lys 
                565                 570                 575     


Pro Ala Leu Glu Ala Val Trp Ala Lys Leu Pro Val Leu Arg Gly Val 
            580                 585                 590         


Pro Tyr Ala Leu Ser Thr Ala Gln Val Val Ala Ile Ala Cys Ile Ser 
        595                 600                 605             


Gly Gln Gln Ala Leu Glu Ala Ile Glu Ala His Met Pro Thr Leu Arg 
    610                 615                 620                 


Gln Ala Pro His Gly Leu Ser Pro Glu Arg Val Ala Ala Ile Ala Cys 
625                 630                 635                 640 


Ile Gly Gly Arg Ser Ala Val Glu Ala 
                645                 


<210>  29
<211>  579
<212>  PRT
<213>  Ralstonia solanacearum

<220>
<221> variant
<222> 246
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 247
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 248
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 249
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 250
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 251
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 252
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 253
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 254
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 255
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 256
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 257
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 258
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 259
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 260
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 261
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 262
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 263
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 264
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 265
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 266
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 267
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 268
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 269
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 270
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 271
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 272
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 273
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 274
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 275
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 276
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 277
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 278
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 279
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 280
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 281
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 282
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 283
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 284
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 285
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 286
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 287
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 288
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 289
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 290
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 291
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 292
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 293
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 294
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 295
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 296
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 297
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 298
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 299
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 300
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 301
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 302
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 303
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 304
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 305
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 306
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 307
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 308
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 309
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 310
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 311
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 312
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 313
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 314
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 315
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 316
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 317
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 318
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 319
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 320
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 321
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 322
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 323
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 324
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 325
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 326
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 327
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 328
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 329
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 330
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 331
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 332
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 333
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 334
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 335
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 336
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 337
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 338
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 339
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 340
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 341
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 342
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 343
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 344
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 345
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 346
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 347
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 348
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 349
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 350
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<400>  29

Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys 
1               5                   10                  15      


Arg Ala Leu Glu Ala Val Cys Val Gln Leu Pro Val Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Arg Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Lys 
        35                  40                  45              


Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala His Leu Leu Asp Leu 
    50                  55                  60                  


Leu Gly Ala Pro Tyr Val Leu Asp Thr Glu Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp Leu 
                85                  90                  95      


Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val 
            100                 105                 110         


Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys 
        115                 120                 125             


Ala Asp Leu Leu Glu Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu 
    130                 135                 140                 


Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu 
145                 150                 155                 160 


Ala Val Lys Ala His Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu 
                165                 170                 175     


Ser Thr Ala Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln 
            180                 185                 190         


Ala Leu Glu Ala Val Lys Ala Gln Leu Leu Asp Leu Arg Gly Ala Pro 
        195                 200                 205             


Tyr Ala Leu Ser Thr Ala Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
    210                 215                 220                 


Gly Lys Gln Ala Leu Glu Gly Ile Gly Glu Gln Leu Arg Lys Leu Arg 
225                 230                 235                 240 


Thr Ala Pro Tyr Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Ser 
            340                 345                 350         


Thr Glu Gln Val Val Ala Ile Ala Ser Ser His Gly Gly Lys Gln Ala 
        355                 360                 365             


Leu Glu Ala Val Arg Ala Leu Phe Pro Asp Leu Arg Ala Ala Pro Tyr 
    370                 375                 380                 


Ala Leu Ser Thr Ala Gln Leu Val Ala Ile Ala Ser Asn Pro Gly Gly 
385                 390                 395                 400 


Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Arg Glu Leu Arg Ala 
                405                 410                 415     


Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


His Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Arg Gly 
        435                 440                 445             


Leu Arg Ala Ala Pro Tyr Gly Leu Ser Thr Ala Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Ser Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Trp Ala Leu 
465                 470                 475                 480 


Leu Pro Val Leu Arg Ala Thr Pro Tyr Asp Leu Asn Thr Ala Gln Val 
                485                 490                 495     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Pro Ala Leu Glu Ala Val 
            500                 505                 510         


Trp Ala Lys Leu Pro Val Leu Arg Gly Val Pro Tyr Ala Leu Ser Thr 
        515                 520                 525             


Ala Gln Val Val Ala Ile Ala Cys Ile Ser Gly Gln Gln Ala Leu Glu 
    530                 535                 540                 


Ala Ile Glu Ala His Met Pro Thr Leu Arg Gln Ala Pro His Ser Leu 
545                 550                 555                 560 


Ser Pro Glu Arg Val Ala Ala Ile Ala Cys Ile Gly Gly Arg Ser Ala 
                565                 570                 575     


Val Glu Ala 
            


<210>  30
<211>  614
<212>  PRT
<213>  Ralstonia solanacearum

<220>
<221> variant
<222> 246
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 247
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 248
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 249
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 250
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 251
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 252
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 253
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 254
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 255
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 256
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 257
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 258
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 259
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 260
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 261
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 262
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 263
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 264
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 265
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 266
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 267
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 268
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 269
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 270
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 271
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 272
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 273
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 274
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 275
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 276
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 277
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 278
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 279
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 280
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 281
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 282
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 283
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 284
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 285
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 286
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 287
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 288
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 289
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 290
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 291
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 292
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 293
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 294
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 295
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 296
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 297
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 298
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 299
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 300
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 301
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 302
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 303
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 304
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 305
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 306
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 307
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 308
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 309
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 310
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 311
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 312
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 313
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 314
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 315
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 316
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 317
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 318
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 319
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 320
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 321
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 322
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 323
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 324
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 325
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 326
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 327
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 328
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 329
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 330
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 331
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 332
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 333
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 334
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 335
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 336
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 337
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 338
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 339
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 340
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 341
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 342
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 343
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 344
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 345
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 346
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 347
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 348
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 349
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 350
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 351
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 352
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 353
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 354
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 355
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 356
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 357
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 358
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 359
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 360
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 361
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 362
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 363
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 364
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 365
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 366
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 367
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 368
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 369
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 370
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 371
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 372
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 373
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 374
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 375
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 376
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 377
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 378
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 379
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 380
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 381
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 382
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 383
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 384
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"
<220>
<221> variant
<222> 385
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 386
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 387
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 388
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 389
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 390
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 391
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 392
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 393
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 394
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 395
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 396
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 397
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 398
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 399
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 400
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 401
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 402
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 403
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 404
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 405
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 406
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 407
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 408
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 409
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 410
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 411
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 412
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 413
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 414
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 415
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 416
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 417
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 418
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 419
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 420
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<400>  30

Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Thr Gly Gly Lys 
1               5                   10                  15      


Arg Ala Leu Glu Ala Val Cys Val Gln Leu Pro Val Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Arg Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Lys 
        35                  40                  45              


Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala His Leu Leu Asp Leu 
    50                  55                  60                  


Leu Gly Ala Pro Tyr Val Leu Asp Thr Glu Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp Leu 
                85                  90                  95      


Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val 
            100                 105                 110         


Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys 
        115                 120                 125             


Ala Asp Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu 
    130                 135                 140                 


Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu 
145                 150                 155                 160 


Ala Val Lys Ala Gln Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu 
                165                 170                 175     


Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
            180                 185                 190         


Ala Leu Glu Ala Val Lys Ala Gln Leu Leu Asp Leu Arg Gly Ala Pro 
        195                 200                 205             


Tyr Ala Leu Ser Thr Ala Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
    210                 215                 220                 


Gly Lys Gln Ala Leu Glu Gly Ile Gly Glu Gln Leu Leu Lys Leu Arg 
225                 230                 235                 240 


Thr Ala Pro Tyr Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Leu Ser Thr Ala Gln Leu Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Pro Gly Gly Lys Gln Ala Leu Glu Ala Ile Arg Ala Leu Phe Arg Glu 
        435                 440                 445             


Leu Arg Ala Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu 
465                 470                 475                 480 


Phe Arg Gly Leu Arg Ala Ala Pro Tyr Gly Leu Ser Thr Ala Gln Val 
                485                 490                 495     


Val Ala Val Ala Ser Ser Asn Gly Gly Lys Gln Ala Leu Glu Ala Val 
            500                 505                 510         


Trp Ala Leu Leu Pro Val Leu Arg Ala Thr Pro Tyr Asp Leu Asn Thr 
        515                 520                 525             


Ala Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Pro Ala Leu 
    530                 535                 540                 


Glu Ala Val Trp Ala Lys Leu Pro Val Leu Arg Gly Val Pro Tyr Glu 
545                 550                 555                 560 


Leu Ser Thr Ala Gln Val Val Ala Ile Ala Cys Ile Ser Gly Gln Gln 
                565                 570                 575     


Ala Leu Glu Val Ile Glu Ala His Met Pro Thr Leu Arg Gln Ala Pro 
            580                 585                 590         


His Ser Leu Ser Pro Glu Arg Val Ala Ala Ile Ala Cys Ile Gly Gly 
        595                 600                 605             


Arg Ser Ala Val Glu Ala 
    610                 


<210>  31
<211>  559
<212>  PRT
<213>  Ralstonia solanacearum

<220>
<221> variant
<222> 211
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 212
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 213
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 214
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 215
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 216
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 217
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 218
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 219
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 220
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 221
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 222
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 223
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 224
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 225
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 226
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 227
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 228
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 229
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 230
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 231
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 232
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 233
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 234
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 235
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 236
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 237
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 238
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 239
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 240
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 241
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 242
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 243
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 244
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 245
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 246
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 247
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 248
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 249
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 250
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 251
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 252
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 253
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 254
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 255
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 256
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 257
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 258
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 259
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 260
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 261
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 262
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 263
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 264
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 265
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 266
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 267
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 268
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 269
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 270
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 271
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 272
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 273
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 274
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 275
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 276
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 277
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 278
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 279
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 280
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 281
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 282
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 283
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 284
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 285
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 286
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 287
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 288
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 289
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 290
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 291
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 292
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 293
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 294
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 295
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 296
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 297
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 298
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 299
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 300
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 301
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 302
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 303
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 304
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 305
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 306
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 307
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 308
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 309
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 310
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 311
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 312
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 313
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 314
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 315
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 316
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 317
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 318
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 319
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 320
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 321
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 322
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 323
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 324
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 325
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 326
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 327
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 328
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 329
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 330
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 331
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 332
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 333
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 334
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 335
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 336
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 337
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 338
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 339
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 340
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 341
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 342
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 343
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 344
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 345
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 346
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 347
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 348
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 349
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 350
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 351
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 352
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 353
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 354
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 355
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 356
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 357
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 358
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 359
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 360
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 361
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 362
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 363
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 364
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 365
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 366
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 367
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 368
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 369
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 370
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 371
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 372
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 373
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 374
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 375
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 376
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 377
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 378
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 379
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 380
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 381
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 382
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 383
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 384
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 385
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<400>  31

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn Lys Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Ala Val Lys Ala His Leu Leu Asp Leu Leu Gly Ala 
            20                  25                  30          


Pro Tyr Val Leu Asp Thr Glu Gln Val Val Ala Ile Ala Ser His Asn 
        35                  40                  45              


Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp Leu Leu Asp Leu 
    50                  55                  60                  


Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala 
65                  70                  75                  80  


Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala Asp Leu 
                85                  90                  95      


Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val 
            100                 105                 110         


Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys 
        115                 120                 125             


Ala Gln Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu 
    130                 135                 140                 


Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu 
145                 150                 155                 160 


Ala Val Lys Ala Gln Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu 
                165                 170                 175     


Ser Thr Glu Gln Val Val Ala Ile Ala Ser Ser His Gly Gly Lys Gln 
            180                 185                 190         


Ala Leu Glu Ala Val Arg Ala Leu Phe Pro Asp Leu Arg Ala Ala Pro 
        195                 200                 205             


Tyr Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Leu Ser Thr Ala Gln Leu Val Ala Ile Ala Ser Asn Pro Gly Gly 
385                 390                 395                 400 


Lys Gln Ala Leu Glu Ala Ile Arg Ala Leu Phe Arg Glu Leu Arg Ala 
                405                 410                 415     


Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


His Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Arg Gly 
        435                 440                 445             


Leu Arg Ala Ala Pro Tyr Gly Leu Ser Thr Ala Gln Val Val Ala Val 
    450                 455                 460                 


Ala Ser Ser Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Trp Ala Leu 
465                 470                 475                 480 


Leu Pro Val Leu Arg Ala Thr Pro Tyr Asp Leu Asn Thr Ala Gln Val 
                485                 490                 495     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Pro Ala Leu Glu Ala Val 
            500                 505                 510         


Trp Ala Lys Leu Pro Val Leu Arg Gly Val Pro Tyr Glu Leu Ser Thr 
        515                 520                 525             


Ala Gln Val Val Ala Ile Ala Cys Ile Ser Gly Gln Gln Ala Leu Glu 
    530                 535                 540                 


Val Ile Glu Ala His Met Pro Thr Leu Arg Gln Ala Pro His Ser 
545                 550                 555                 


<210>  32
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Generic repeat

<220>
<221> variant
<222> 12
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221> variant
<222> 13
<223> /replace="Ala"
      /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<400>  32

Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser Xaa Xaa Gly Gly Lys 
1               5                   10                  15      


Pro Ala Leu Glu Ala Val Lys Ala Leu Leu Leu Glu Leu Arg Ala Ala 
            20                  25                  30          


Pro Tyr Glu 
        35                    


