                         SEQUENCE LISTING

<110>  Orbsen Therapeutics Limited
 
<120>  Immuno-modulatory and Therapeutic Agents and Compositions, and 
       Uses Thereof

<130>  P39937WO

<150>  GB 1306886.1
<151>  2013-04-16

<150>  GB 1314544.6
<151>  2013-08-14

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  3491
<212>  DNA
<213>  Homo sapiens

<400>  1
gcccggagaa gcaggctcag gagggaggga gccagaggaa aagaagagga ggagaaggag       60

gaggacccgg ggagggaggc gcggcgcggg aggaggaggg gcgcagccgc ggagccagtg      120

gccccgcttg gacgcgctgc tctccagata cccccggagc tccagccgcg cggatcgcgc      180

gctcccgccg ctctgcccct aaacttctgc cgtagctccc tttcaagcca gcgaatttat      240

tccttaaaac cagaaactga acctcggcac gggaaaggag tccgcggagg agcaaaacca      300

cagcagagca agaagagctt cagagagcag ccttcccgga gcaccaactc cgtgtcggga      360

gtgcagaaac caacaagtga gagggcgccg cgttcccggg gcgcagctgc gggcggcggg      420

agcaggcgca ggaggaggaa gcgagcgccc ccgagccccg agcccgagtc cccgagcctg      480

agccgcaatc gctgcggtac tctgctccgg attcgtgtgc gcgggctgcg ccgagcgctg      540

ggcaggaggc ttcgttttgc cctggttgca agcagcggct gggagcagcc ggtccctggg      600

gaatatgcgg cgcgcgtgga tcctgctcac cttgggcttg gtggcctgcg tgtcggcgga      660

gtcgagagca gagctgacat ctgataaaga catgtacctt gacaacagct ccattgaaga      720

agcttcagga gtgtatccta ttgatgacga tgactacgct tctgcgtctg gctcgggagc      780

tgatgaggat gtagagagtc cagagctgac aacatctcga ccacttccaa agatactgtt      840

gactagtgct gctccaaaag tggaaaccac gacgctgaat atacagaaca agatacctgc      900

tcagacaaag tcacctgaag aaactgataa agagaaagtt cacctctctg actcagaaag      960

gaaaatggac ccagccgaag aggatacaaa tgtgtatact gagaaacact cagacagtct     1020

gtttaaacgg acagaagtcc tagcagctgt cattgctggt ggagttattg gctttctctt     1080

tgcaattttt cttatcctgc tgttggtgta tcgcatgaga aagaaggatg aaggaagcta     1140

tgaccttgga gaacgcaaac catccagtgc tgcttatcag aaggcaccta ctaaggagtt     1200

ttatgcgtaa aactccaact tagtgtctct atttatgaga tcactgaact tttcaaaata     1260

aagcttttgc atagaataat gaagatcttt gttttttgtt ttcattaaag agccattctg     1320

gcactttaat gataaaatcc cattgtattt aaaacatttc atgtatttct ttagaacaac     1380

ataaaattaa aatttaacat ctgcagtgtt ctgtgaatag cagtggcaaa atattatgtt     1440

atgaaaaccc tcgatgttca tggaattggt ttaaactttt atgcgcaaat acaaaatgat     1500

tgtctttttc ctatgactca aagatgaaag ctgtttcatt tgtgtcagca tgtctcagat     1560

tgaccttacc aagttggtct tactttgtta atttatctgt tgtccccttc ctctcctctg     1620

ccctcccttc ttgtgccctt aaaaccaaac cctatgcctt ttgtagctgt catggtgcaa     1680

tttgtctttg gaaaattcag ataatggtaa tttagtgtat atgtgatttt caaatatgta     1740

aactttaact tccactttgt ataaattttt aagtgtcaga ctatccattt tacacttgct     1800

ttatttttca ttacctgtag ctttgggcag atttgcaaca gcaaattaat gtgtaaaatt     1860

ggattattac tacaaaaccg tttagtcata tctatctaat cagatcttct tttgggagga     1920

tttgatgtaa gttactgaca agcctcagca aacccaaaga tgttaacagt attttaagaa     1980

gttgctgcag attcctttgg ccactgtatt tgttaatttc ttgcaatttg aaggtacgag     2040

tagaggttta aagaaaaatc agtttttgtt cttaaaaatg catttaagtt gtaaacgtct     2100

ttttaagcct ttgaagtgcc tctgattcta tgtaacttgt tgcagactgg tgttaatgag     2160

tatatgtaac agtttaaaaa aaaagttggt attttataag cacagacaat tctaatggta     2220

acttttgtag tcttatgaat agacataaat tgtaatttgg gaacataaaa actactgaat     2280

aaatcatgtg gcctaatatt gaaaatgtca ctgttataaa ttttgtacat ttttgatcaa     2340

atgtacatct cccctttgct aacggccgtc tgctctcaag gatgacgtgg gtttgatttc     2400

taagtgtttc acagtgtctg taaatcaaga ccaaagagcc tgtcgatgag actgtttatt     2460

accagattca cttctgaatt ggccagagga aatctgaatg tattatcctg tgtgtgtcta     2520

ggtagagata ttggaaggct gccaggggat ttcgaagttt gcaaccttta taggataact     2580

gatggcaata ttaagacaga cgcctgcttt tgcaaataac ttacaagact gtaaattcca     2640

aagatctgaa tggggctttc ctgatgttgg tatctaaggc ttaggcctat agattgattt     2700

acctttggaa ttgtgctcca aatgtctact gaagcttaac cgaagaacta ataaatggac     2760

tacagtagct cacgttacag ggaaggaggg taggcaggga ggctctgtgt gttaaaatga     2820

gggtctcact gctttaggat tgaagtggct ggaaagagtg atgcctgggg aaggagatgg     2880

agttatgagg gtactgtggc tggtactttc tgtactaaac atttcctttt tctattttac     2940

cactaatttt gttttaaact gtgagccgtc caagtcagaa gaagacagca aaaaaagcaa     3000

cttttccaac atacaattta cttttaataa agtatgaata tttcattttg agaacattcc     3060

ctggaattgc cacataattc attaaaaaca tttttttaag caacacttgg aacagtgttt     3120

actttaaatc cttaatggcc ttaattaatt ctcagattcc tgccccatca cttacagaac     3180

caattcactt tagagtgact aaaaggaaac gatagcctag ctttctaaag ccacgctgtg     3240

tccctcaatt acagagggta ggaatgggta tacctctaac tgtgcaaagc agagtgaaat     3300

tcaattcata gaataacaac tgctgggaat atccgtgcca ggaaaagaaa aatttctggc     3360

aaatattttg tcactgctgt aaagcaaaat atttgtgaaa gtgccaaaat aaagtctgtc     3420

atgccaaaag taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3480

aaaaaaaaaa a                                                          3491


<210>  2
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcggcgcg cgtggatcct gctcaccttg ggcttggtgg cctgcgtgtc ggcggagtcg       60

agagcagagc tgacatctga taaagacatg taccttgaca acagctccat tgaagaagct      120

tcaggagtgt atcctattga tgacgatgac tacgcttctg cgtctggctc gggagctgat      180

gaggatgtag agagtccaga gctgacaaca tctcgaccac ttccaaagat actgttgact      240

agtgctgctc caaaagtgga aaccacgacg ctgaatatac agaacaagat acctgctcag      300

acaaagtcac ctgaagaaac tgataaagag aaagttcacc tctctgactc agaaaggaaa      360

atggacccag ccgaagagga tacaaatgtg tatactgaga aacactcaga cagtctgttt      420

aaacggacag aagtcctagc agctgtcatt gctggtggag ttattggctt tctctttgca      480

atttttctta tcctgctgtt ggtgtatcgc atgagaaaga aggatgaagg aagctatgac      540

cttggagaac gcaaaccatc cagtgctgct tatcagaagg cacctactaa ggagttttat      600

gcgtaa                                                                 606


<210>  3
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                165                 170                 175     


Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
            180                 185                 190         


Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200     


<210>  4
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu Asp Asn 
1               5                   10                  15      


Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp Asp Asp 
            20                  25                  30          


Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu Ser Pro 
        35                  40                  45              


Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr Ser Ala 
    50                  55                  60                  


Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys Ile Pro 
65                  70                  75                  80  


Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val His Leu 
                85                  90                  95      


Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr Asn Val 
            100                 105                 110         


Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu Val Leu 
        115                 120                 125             


Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala Ile Phe 
    130                 135                 140                 


Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu Gly Ser 
145                 150                 155                 160 


Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln Lys Ala 
                165                 170                 175     


Pro Thr Lys Glu Phe Tyr Ala 
            180             


