                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       HANNA , Yaqub
       NOVERSHTERN , Noa
       RAIS , Yoach
 
<120>  ISOLATED NAIVE PLURIPOTENT STEM CELLS AND METHODS OF GENERATING 
       SAME

<130>  58869

<150>  US 61/814,920
<151>  2013-04-23

<150>  US 61/878,769
<151>  2013-09-17

<150>  US 61/932,935
<151>  2014-01-29

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
ggtaccggat actcaggcca ggcccagaaa                                        30


<210>  2
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
ctcgagtcca cagacctctg gcact                                             25


<210>  3
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
ggtacccatt gagtccaaat cctctttact aggtg                                  35


<210>  4
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
ctcgagctga ggctcatgct gctgg                                             25


<210>  5
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp Lys 
1               5                   10                  15      


Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser Asp 
            20                  25                  30          


Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val Glu 
        35                  40                  45              


Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp Phe 
    50                  55                  60                  


Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val Ala 
65                  70                  75                  80  


Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg Pro Ala Lys Thr Arg 
                85                  90                  95      


Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val Arg Lys Glu Ala Pro 
            100                 105                 110         


Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala Pro Ala Ser Phe Pro 
        115                 120                 125             


Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser Phe Ser Gly Asp Gly 
    130                 135                 140                 


Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys Asp Cys Arg Ala Gln 
145                 150                 155                 160 


Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe Lys Arg Val Gly Cys 
                165                 170                 175     


Gly Glu Cys Ala Ala Cys Gln Val Thr Glu Asp Cys Gly Ala Cys Ser 
            180                 185                 190         


Thr Cys Leu Leu Gln Leu Pro His Asp Val Ala Ser Gly Leu Phe Cys 
        195                 200                 205             


Lys Cys Glu Arg Arg Arg Cys Leu Arg Ile Val Glu Arg Ser Arg Gly 
    210                 215                 220                 


Cys Gly Val Cys Arg Gly Cys Gln Thr Gln Glu Asp Cys Gly His Cys 
225                 230                 235                 240 


Pro Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu Arg Arg Gln Trp Lys 
                245                 250                 255     


Cys Val Gln Arg Arg Cys Leu Arg Gly Lys His Ala Arg Arg Lys Gly 
            260                 265                 270         


Gly Cys Asp Ser Lys Met Ala Ala Arg Arg Arg Pro Gly Ala Gln Pro 
        275                 280                 285             


Leu Pro Pro Pro Pro Pro Ser Gln Ser Pro Glu Pro Thr Glu Pro His 
    290                 295                 300                 


Pro Arg Ala Leu Ala Pro Ser Pro Pro Ala Glu Phe Ile Tyr Tyr Cys 
305                 310                 315                 320 


Val Asp Glu Asp Glu Leu Gln Pro Tyr Thr Asn Arg Arg Gln Asn Arg 
                325                 330                 335     


Lys Cys Gly Ala Cys Ala Ala Cys Leu Arg Arg Met Asp Cys Gly Arg 
            340                 345                 350         


Cys Asp Phe Cys Cys Asp Lys Pro Lys Phe Gly Gly Ser Asn Gln Lys 
        355                 360                 365             


Arg Gln Lys Cys Arg Trp Arg Gln Cys Leu Gln Phe Ala Met Lys Arg 
    370                 375                 380                 


Leu Leu Pro Ser Val Trp Ser Glu Ser Glu Asp Gly Ala Gly Ser Pro 
385                 390                 395                 400 


Pro Pro Tyr Arg Arg Arg Lys Arg Pro Ser Ser Ala Arg Arg His His 
                405                 410                 415     


Leu Gly Pro Thr Leu Lys Pro Thr Leu Ala Thr Arg Thr Ala Gln Pro 
            420                 425                 430         


Asp His Thr Gln Ala Pro Thr Lys Gln Glu Ala Gly Gly Gly Phe Val 
        435                 440                 445             


Leu Pro Pro Pro Gly Thr Asp Leu Val Phe Leu Arg Glu Gly Ala Ser 
    450                 455                 460                 


Ser Pro Val Gln Val Pro Gly Pro Val Ala Ala Ser Thr Glu Ala Leu 
465                 470                 475                 480 


Leu Gln Glu Ala Gln Cys Ser Gly Leu Ser Trp Val Val Ala Leu Pro 
                485                 490                 495     


Gln Val Lys Gln Glu Lys Ala Asp Thr Gln Asp Glu Trp Thr Pro Gly 
            500                 505                 510         


Thr Ala Val Leu Thr Ser Pro Val Leu Val Pro Gly Cys Pro Ser Lys 
        515                 520                 525             


Ala Val Asp Pro Gly Leu Pro Ser Val Lys Gln Glu Pro Pro Asp Pro 
    530                 535                 540                 


Glu Glu Asp Lys Glu Glu Asn Lys Asp Asp Ser Ala Ser Lys Leu Ala 
545                 550                 555                 560 


Pro Glu Glu Glu Ala Gly Gly Ala Gly Thr Pro Val Ile Thr Glu Ile 
                565                 570                 575     


Phe Ser Leu Gly Gly Thr Arg Phe Arg Asp Thr Ala Val Trp Leu Pro 
            580                 585                 590         


Arg Ser Lys Asp Leu Lys Lys Pro Gly Ala Arg Lys Gln 
        595                 600                 605 


<210>  6
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ala His Pro Gly Gly Gly Arg Cys Cys Pro Glu Gln Glu Glu 
1               5                   10                  15      


Gly Glu Ser Ala Ala Gly Gly Ser Gly Ala Gly Gly Asp Ser Ala Ile 
            20                  25                  30          


Glu Gln Gly Gly Gln Gly Ser Ala Leu Ala Pro Ser Pro Val Ser Gly 
        35                  40                  45              


Val Arg Arg Glu Gly Ala Arg Gly Gly Gly Arg Gly Arg Gly Arg Trp 
    50                  55                  60                  


Lys Gln Ala Gly Arg Gly Gly Gly Val Cys Gly Arg Gly Arg Gly Arg 
65                  70                  75                  80  


Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
                85                  90                  95      


Pro Pro Ser Gly Gly Ser Gly Leu Gly Gly Asp Gly Gly Gly Cys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Arg Arg Glu Pro Val Pro 
        115                 120                 125             


Phe Pro Ser Gly Ser Ala Gly Pro Gly Pro Arg Gly Pro Arg Ala Thr 
    130                 135                 140                 


Glu Ser Gly Lys Arg Met Asp Cys Pro Ala Leu Pro Pro Gly Trp Lys 
145                 150                 155                 160 


Lys Glu Glu Val Ile Arg Lys Ser Gly Leu Ser Ala Gly Lys Ser Asp 
                165                 170                 175     


Val Tyr Tyr Phe Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln 
            180                 185                 190         


Leu Ala Arg Tyr Leu Gly Asn Thr Val Asp Leu Ser Ser Phe Asp Phe 
        195                 200                 205             


Arg Thr Gly Lys Met Met Pro Ser Lys Leu Gln Lys Asn Lys Gln Arg 
    210                 215                 220                 


Leu Arg Asn Asp Pro Leu Asn Gln Asn Lys Gly Lys Pro Asp Leu Asn 
225                 230                 235                 240 


Thr Thr Leu Pro Ile Arg Gln Thr Ala Ser Ile Phe Lys Gln Pro Val 
                245                 250                 255     


Thr Lys Val Thr Asn His Pro Ser Asn Lys Val Lys Ser Asp Pro Gln 
            260                 265                 270         


Arg Met Asn Glu Gln Pro Arg Gln Leu Phe Trp Glu Lys Arg Leu Gln 
        275                 280                 285             


Gly Leu Ser Ala Ser Asp Val Thr Glu Gln Ile Ile Lys Thr Met Glu 
    290                 295                 300                 


Leu Pro Lys Gly Leu Gln Gly Val Gly Pro Gly Ser Asn Asp Glu Thr 
305                 310                 315                 320 


Leu Leu Ser Ala Val Ala Ser Ala Leu His Thr Ser Ser Ala Pro Ile 
                325                 330                 335     


Thr Gly Gln Val Ser Ala Ala Val Glu Lys Asn Pro Ala Val Trp Leu 
            340                 345                 350         


Asn Thr Ser Gln Pro Leu Cys Lys Ala Phe Ile Val Thr Asp Glu Asp 
        355                 360                 365             


Ile Arg Lys Gln Glu Glu Arg Val Gln Gln Val Arg Lys Lys Leu Glu 
    370                 375                 380                 


Glu Ala Leu Met Ala Asp Ile Leu Ser Arg Ala Ala Asp Thr Glu Glu 
385                 390                 395                 400 


Met Asp Ile Glu Met Asp Ser Gly Asp Glu Ala 
                405                 410     


<210>  7
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Arg Lys Arg Trp Glu Cys Pro Ala Leu Pro Gln Gly Trp Glu 
1               5                   10                  15      


Arg Glu Glu Val Pro Arg Arg Ser Gly Leu Ser Ala Gly His Arg Asp 
            20                  25                  30          


Val Phe Tyr Tyr Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln 
        35                  40                  45              


Leu Ala Arg Tyr Leu Gly Gly Ser Met Asp Leu Ser Thr Phe Asp Phe 
    50                  55                  60                  


Arg Thr Gly Lys Met Leu Met Ser Lys Met Asn Lys Ser Arg Gln Arg 
65                  70                  75                  80  


Val Arg Tyr Asp Ser Ser Asn Gln Val Lys Gly Lys Pro Asp Leu Asn 
                85                  90                  95      


Thr Ala Leu Pro Val Arg Gln Thr Ala Ser Ile Phe Lys Gln Pro Val 
            100                 105                 110         


Thr Lys Ile Thr Asn His Pro Ser Asn Lys Val Lys Ser Asp Pro Gln 
        115                 120                 125             


Lys Ala Val Asp Gln Pro Arg Gln Leu Phe Trp Glu Lys Lys Leu Ser 
    130                 135                 140                 


Gly Leu Asn Ala Phe Asp Ile Ala Glu Glu Leu Val Lys Thr Met Asp 
145                 150                 155                 160 


Leu Pro Lys Gly Leu Gln Gly Val Gly Pro Gly Cys Thr Asp Glu Thr 
                165                 170                 175     


Leu Leu Ser Ala Ile Ala Ser Ala Leu His Thr Ser Thr Met Pro Ile 
            180                 185                 190         


Thr Gly Gln Leu Ser Ala Ala Val Glu Lys Asn Pro Gly Val Trp Leu 
        195                 200                 205             


Asn Thr Thr Gln Pro Leu Cys Lys Ala Phe Met Val Thr Asp Glu Asp 
    210                 215                 220                 


Ile Arg Lys Gln Glu Glu Leu Val Gln Gln Val Arg Lys Arg Leu Glu 
225                 230                 235                 240 


Glu Ala Leu Met Ala Asp Met Leu Ala His Val Glu Glu Leu Ala Arg 
                245                 250                 255     


Asp Gly Glu Ala Pro Leu Asp Lys Ala Cys Ala Glu Asp Asp Asp Glu 
            260                 265                 270         


Glu Asp Glu Glu Glu Glu Glu Glu Glu Pro Asp Pro Asp Pro Glu Met 
        275                 280                 285             


Glu His Val 
    290     


<210>  8
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Thr Thr Gly Leu Glu Ser Leu Ser Leu Gly Asp Arg Gly Ala 
1               5                   10                  15      


Ala Pro Thr Val Thr Ser Ser Glu Arg Leu Val Pro Asp Pro Pro Asn 
            20                  25                  30          


Asp Leu Arg Lys Glu Asp Val Ala Met Glu Leu Glu Arg Val Gly Glu 
        35                  40                  45              


Asp Glu Glu Gln Met Met Ile Lys Arg Ser Ser Glu Cys Asn Pro Leu 
    50                  55                  60                  


Leu Gln Glu Pro Ile Ala Ser Ala Gln Phe Gly Ala Thr Ala Gly Thr 
65                  70                  75                  80  


Glu Cys Arg Lys Ser Val Pro Cys Gly Trp Glu Arg Val Val Lys Gln 
                85                  90                  95      


Arg Leu Phe Gly Lys Thr Ala Gly Arg Phe Asp Val Tyr Phe Ile Ser 
            100                 105                 110         


Pro Gln Gly Leu Lys Phe Arg Ser Lys Ser Ser Leu Ala Asn Tyr Leu 
        115                 120                 125             


His Lys Asn Gly Glu Thr Ser Leu Lys Pro Glu Asp Phe Asp Phe Thr 
    130                 135                 140                 


Val Leu Ser Lys Arg Gly Ile Lys Ser Arg Tyr Lys Asp Cys Ser Met 
145                 150                 155                 160 


Ala Ala Leu Thr Ser His Leu Gln Asn Gln Ser Asn Asn Ser Asn Trp 
                165                 170                 175     


Asn Leu Arg Thr Arg Ser Lys Cys Lys Lys Asp Val Phe Met Pro Pro 
            180                 185                 190         


Ser Ser Ser Ser Glu Leu Gln Glu Ser Arg Gly Leu Ser Asn Phe Thr 
        195                 200                 205             


Ser Thr His Leu Leu Leu Lys Glu Asp Glu Gly Val Asp Asp Val Asn 
    210                 215                 220                 


Phe Arg Lys Val Arg Lys Pro Lys Gly Lys Val Thr Ile Leu Lys Gly 
225                 230                 235                 240 


Ile Pro Ile Lys Lys Thr Lys Lys Gly Cys Arg Lys Ser Cys Ser Gly 
                245                 250                 255     


Phe Val Gln Ser Asp Ser Lys Arg Glu Ser Val Cys Asn Lys Ala Asp 
            260                 265                 270         


Ala Glu Ser Glu Pro Val Ala Gln Lys Ser Gln Leu Asp Arg Thr Val 
        275                 280                 285             


Cys Ile Ser Asp Ala Gly Ala Cys Gly Glu Thr Leu Ser Val Thr Ser 
    290                 295                 300                 


Glu Glu Asn Ser Leu Val Lys Lys Lys Glu Arg Ser Leu Ser Ser Gly 
305                 310                 315                 320 


Ser Asn Phe Cys Ser Glu Gln Lys Thr Ser Gly Ile Ile Asn Lys Phe 
                325                 330                 335     


Cys Ser Ala Lys Asp Ser Glu His Asn Glu Lys Tyr Glu Asp Thr Phe 
            340                 345                 350         


Leu Glu Ser Glu Glu Ile Gly Thr Lys Val Glu Val Val Glu Arg Lys 
        355                 360                 365             


Glu His Leu His Thr Asp Ile Leu Lys Arg Gly Ser Glu Met Asp Asn 
    370                 375                 380                 


Asn Cys Ser Pro Thr Arg Lys Asp Phe Thr Gly Glu Lys Ile Phe Gln 
385                 390                 395                 400 


Glu Asp Thr Ile Pro Arg Thr Gln Ile Glu Arg Arg Lys Thr Ser Leu 
                405                 410                 415     


Tyr Phe Ser Ser Lys Tyr Asn Lys Glu Ala Leu Ser Pro Pro Arg Arg 
            420                 425                 430         


Lys Ala Phe Lys Lys Trp Thr Pro Pro Arg Ser Pro Phe Asn Leu Val 
        435                 440                 445             


Gln Glu Thr Leu Phe His Asp Pro Trp Lys Leu Leu Ile Ala Thr Ile 
    450                 455                 460                 


Phe Leu Asn Arg Thr Ser Gly Lys Met Ala Ile Pro Val Leu Trp Lys 
465                 470                 475                 480 


Phe Leu Glu Lys Tyr Pro Ser Ala Glu Val Ala Arg Thr Ala Asp Trp 
                485                 490                 495     


Arg Asp Val Ser Glu Leu Leu Lys Pro Leu Gly Leu Tyr Asp Leu Arg 
            500                 505                 510         


Ala Lys Thr Ile Val Lys Phe Ser Asp Glu Tyr Leu Thr Lys Gln Trp 
        515                 520                 525             


Lys Tyr Pro Ile Glu Leu His Gly Ile Gly Lys Tyr Gly Asn Asp Ser 
    530                 535                 540                 


Tyr Arg Ile Phe Cys Val Asn Glu Trp Lys Gln Val His Pro Glu Asp 
545                 550                 555                 560 


His Lys Leu Asn Lys Tyr His Asp Trp Leu Trp Glu Asn His Glu Lys 
                565                 570                 575     


Leu Ser Leu Ser 
            580 


<210>  9
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  10
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  11
<211>  1912
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Thr Glu Thr 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Arg Met Leu Leu Cys Arg 
65                  70                  75                  80  


Gln Leu Gly Asp Ser Ser Gly Glu Gly Pro Glu Phe Val Glu Glu Glu 
                85                  90                  95      


Glu Glu Val Ala Leu Arg Ser Asp Ser Glu Gly Ser Asp Tyr Thr Pro 
            100                 105                 110         


Gly Lys Lys Lys Lys Lys Lys Leu Gly Pro Lys Lys Glu Lys Lys Ser 
        115                 120                 125             


Lys Ser Lys Arg Lys Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp 
    130                 135                 140                 


Ser Lys Glu Pro Lys Ser Ser Ala Gln Leu Leu Glu Asp Trp Gly Met 
145                 150                 155                 160 


Glu Asp Ile Asp His Val Phe Ser Glu Glu Asp Tyr Arg Thr Leu Thr 
                165                 170                 175     


Asn Tyr Lys Ala Phe Ser Gln Phe Val Arg Pro Leu Ile Ala Ala Lys 
            180                 185                 190         


Asn Pro Lys Ile Ala Val Ser Lys Met Met Met Val Leu Gly Ala Lys 
        195                 200                 205             


Trp Arg Glu Phe Ser Thr Asn Asn Pro Phe Lys Gly Ser Ser Gly Ala 
    210                 215                 220                 


Ser Val Ala Ala Ala Ala Ala Ala Ala Val Ala Val Val Glu Ser Met 
225                 230                 235                 240 


Val Thr Ala Thr Glu Val Ala Pro Pro Pro Pro Pro Val Glu Val Pro 
                245                 250                 255     


Ile Arg Lys Ala Lys Thr Lys Glu Gly Lys Gly Pro Asn Ala Arg Arg 
            260                 265                 270         


Lys Pro Lys Gly Ser Pro Arg Val Pro Asp Ala Lys Lys Pro Lys Pro 
        275                 280                 285             


Lys Lys Val Ala Pro Leu Lys Ile Lys Leu Gly Gly Phe Gly Ser Lys 
    290                 295                 300                 


Arg Lys Arg Ser Ser Ser Glu Asp Asp Asp Leu Asp Val Glu Ser Asp 
305                 310                 315                 320 


Phe Asp Asp Ala Ser Ile Asn Ser Tyr Ser Val Ser Asp Gly Ser Thr 
                325                 330                 335     


Ser Arg Ser Ser Arg Ser Arg Lys Lys Leu Arg Thr Thr Lys Lys Lys 
            340                 345                 350         


Lys Lys Gly Glu Glu Glu Val Thr Ala Val Asp Gly Tyr Glu Thr Asp 
        355                 360                 365             


His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly Gly Glu Ile Ile Leu 
    370                 375                 380                 


Cys Asp Thr Cys Pro Arg Ala Tyr His Met Val Cys Leu Asp Pro Asp 
385                 390                 395                 400 


Met Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys Pro His Cys Glu Lys 
                405                 410                 415     


Glu Gly Ile Gln Trp Glu Ala Lys Glu Asp Asn Ser Glu Gly Glu Glu 
            420                 425                 430         


Ile Leu Glu Glu Val Gly Gly Asp Leu Glu Glu Glu Asp Asp His His 
        435                 440                 445             


Met Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys 
    450                 455                 460                 


Asp Thr Cys Pro Ser Ser Tyr His Ile His Cys Leu Asn Pro Pro Leu 
465                 470                 475                 480 


Pro Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro 
                485                 490                 495     


Ala Leu Lys Gly Lys Val Gln Lys Ile Leu Ile Trp Lys Trp Gly Gln 
            500                 505                 510         


Pro Pro Ser Pro Thr Pro Val Pro Arg Pro Pro Asp Ala Asp Pro Asn 
        515                 520                 525             


Thr Pro Ser Pro Lys Pro Leu Glu Gly Arg Pro Glu Arg Gln Phe Phe 
    530                 535                 540                 


Val Lys Trp Gln Gly Met Ser Tyr Trp His Cys Ser Trp Val Ser Glu 
545                 550                 555                 560 


Leu Gln Leu Glu Leu His Cys Gln Val Met Phe Arg Asn Tyr Gln Arg 
                565                 570                 575     


Lys Asn Asp Met Asp Glu Pro Pro Ser Gly Asp Phe Gly Gly Asp Glu 
            580                 585                 590         


Glu Lys Ser Arg Lys Arg Lys Asn Lys Asp Pro Lys Phe Ala Glu Met 
        595                 600                 605             


Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met Met Ile 
    610                 615                 620                 


His Arg Ile Leu Asn His Ser Val Asp Lys Lys Gly His Val His Tyr 
625                 630                 635                 640 


Leu Ile Lys Trp Arg Asp Leu Pro Tyr Asp Gln Ala Ser Trp Glu Ser 
                645                 650                 655     


Glu Asp Val Glu Ile Gln Asp Tyr Asp Leu Phe Lys Gln Ser Tyr Trp 
            660                 665                 670         


Asn His Arg Glu Leu Met Arg Gly Glu Glu Gly Arg Pro Gly Lys Lys 
        675                 680                 685             


Leu Lys Lys Val Lys Leu Arg Lys Leu Glu Arg Pro Pro Glu Thr Pro 
    690                 695                 700                 


Thr Val Asp Pro Thr Val Lys Tyr Glu Arg Gln Pro Glu Tyr Leu Asp 
705                 710                 715                 720 


Ala Thr Gly Gly Thr Leu His Pro Tyr Gln Met Glu Gly Leu Asn Trp 
                725                 730                 735     


Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu 
            740                 745                 750         


Met Gly Leu Gly Lys Thr Val Gln Thr Ala Val Phe Leu Tyr Ser Leu 
        755                 760                 765             


Tyr Lys Glu Gly His Ser Lys Gly Pro Phe Leu Val Ser Ala Pro Leu 
    770                 775                 780                 


Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe Glu Met Trp Ala Pro Asp 
785                 790                 795                 800 


Met Tyr Val Val Thr Tyr Val Gly Asp Lys Asp Ser Arg Ala Ile Ile 
                805                 810                 815     


Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn Ala Ile Arg Gly Gly Lys 
            820                 825                 830         


Lys Ala Ser Arg Met Lys Lys Glu Ala Ser Val Lys Phe His Val Leu 
        835                 840                 845             


Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp Met Ala Ile Leu Gly Ser 
    850                 855                 860                 


Ile Asp Trp Ala Cys Leu Ile Val Asp Glu Ala His Arg Leu Lys Asn 
865                 870                 875                 880 


Asn Gln Ser Lys Phe Phe Arg Val Leu Asn Gly Tyr Ser Leu Gln His 
                885                 890                 895     


Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu 
            900                 905                 910         


Phe His Leu Leu Asn Phe Leu Thr Pro Glu Arg Phe His Asn Leu Glu 
        915                 920                 925             


Gly Phe Leu Glu Glu Phe Ala Asp Ile Ala Lys Glu Asp Gln Ile Lys 
    930                 935                 940                 


Lys Leu His Asp Met Leu Gly Pro His Met Leu Arg Arg Leu Lys Ala 
945                 950                 955                 960 


Asp Val Phe Lys Asn Met Pro Ser Lys Thr Glu Leu Ile Val Arg Val 
                965                 970                 975     


Glu Leu Ser Pro Met Gln Lys Lys Tyr Tyr Lys Tyr Ile Leu Thr Arg 
            980                 985                 990         


Asn Phe Glu Ala Leu Asn Ala Arg  Gly Gly Gly Asn Gln  Val Ser Leu 
        995                 1000                 1005             


Leu Asn  Val Val Met Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr 
    1010                 1015                 1020             


Leu Phe  Pro Val Ala Ala Met  Glu Ala Pro Lys Met  Pro Asn Gly 
    1025                 1030                 1035             


Met Tyr  Asp Gly Ser Ala Leu  Ile Arg Ala Ser Gly  Lys Leu Leu 
    1040                 1045                 1050             


Leu Leu  Gln Lys Met Leu Lys  Asn Leu Lys Glu Gly  Gly His Arg 
    1055                 1060                 1065             


Val Leu  Ile Phe Ser Gln Met  Thr Lys Met Leu Asp  Leu Leu Glu 
    1070                 1075                 1080             


Asp Phe  Leu Glu His Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly 
    1085                 1090                 1095             


Gly Ile  Thr Gly Asn Met Arg  Gln Glu Ala Ile Asp  Arg Phe Asn 
    1100                 1105                 1110             


Ala Pro  Gly Ala Gln Gln Phe  Cys Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Ile Asn Leu  Ala Thr Ala Asp Thr  Val Ile Ile 
    1130                 1135                 1140             


Tyr Asp  Ser Asp Trp Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Asn Lys Lys Val Met  Ile Tyr Arg 
    1160                 1165                 1170             


Phe Val  Thr Arg Ala Ser Val  Glu Glu Arg Ile Thr  Gln Val Ala 
    1175                 1180                 1185             


Lys Lys  Lys Met Met Leu Thr  His Leu Val Val Arg  Pro Gly Leu 
    1190                 1195                 1200             


Gly Ser  Lys Thr Gly Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile 
    1205                 1210                 1215             


Leu Lys  Phe Gly Thr Glu Glu  Leu Phe Lys Asp Glu  Ala Thr Asp 
    1220                 1225                 1230             


Gly Gly  Gly Asp Asn Lys Glu  Gly Glu Asp Ser Ser  Val Ile His 
    1235                 1240                 1245             


Tyr Asp  Asp Lys Ala Ile Glu  Arg Leu Leu Asp Arg  Asn Gln Asp 
    1250                 1255                 1260             


Glu Thr  Glu Asp Thr Glu Leu  Gln Gly Met Asn Glu  Tyr Leu Ser 
    1265                 1270                 1275             


Ser Phe  Lys Val Ala Gln Tyr  Val Val Arg Glu Glu  Glu Met Gly 
    1280                 1285                 1290             


Glu Glu  Glu Glu Val Glu Arg  Glu Ile Ile Lys Gln  Glu Glu Ser 
    1295                 1300                 1305             


Val Asp  Pro Asp Tyr Trp Glu  Lys Leu Leu Arg His  His Tyr Glu 
    1310                 1315                 1320             


Gln Gln  Gln Glu Asp Leu Ala  Arg Asn Leu Gly Lys  Gly Lys Arg 
    1325                 1330                 1335             


Ile Arg  Lys Gln Val Asn Tyr  Asn Asp Gly Ser Gln  Glu Asp Arg 
    1340                 1345                 1350             


Asp Trp  Gln Asp Asp Gln Ser  Asp Asn Gln Ser Asp  Tyr Ser Val 
    1355                 1360                 1365             


Ala Ser  Glu Glu Gly Asp Glu  Asp Phe Asp Glu Arg  Ser Glu Ala 
    1370                 1375                 1380             


Pro Arg  Arg Pro Ser Arg Lys  Gly Leu Arg Asn Asp  Lys Asp Lys 
    1385                 1390                 1395             


Pro Leu  Pro Pro Leu Leu Ala  Arg Val Gly Gly Asn  Ile Glu Val 
    1400                 1405                 1410             


Leu Gly  Phe Asn Ala Arg Gln  Arg Lys Ala Phe Leu  Asn Ala Ile 
    1415                 1420                 1425             


Met Arg  Tyr Gly Met Pro Pro  Gln Asp Ala Phe Thr  Thr Gln Trp 
    1430                 1435                 1440             


Leu Val  Arg Asp Leu Arg Gly  Lys Ser Glu Lys Glu  Phe Lys Ala 
    1445                 1450                 1455             


Tyr Val  Ser Leu Phe Met Arg  His Leu Cys Glu Pro  Gly Ala Asp 
    1460                 1465                 1470             


Gly Ala  Glu Thr Phe Ala Asp  Gly Val Pro Arg Glu  Gly Leu Ser 
    1475                 1480                 1485             


Arg Gln  His Val Leu Thr Arg  Ile Gly Val Met Ser  Leu Ile Arg 
    1490                 1495                 1500             


Lys Lys  Val Gln Glu Phe Glu  His Val Asn Gly Arg  Trp Ser Met 
    1505                 1510                 1515             


Pro Glu  Leu Ala Glu Val Glu  Glu Asn Lys Lys Met  Ser Gln Pro 
    1520                 1525                 1530             


Gly Ser  Pro Ser Pro Lys Thr  Pro Thr Pro Ser Thr  Pro Gly Asp 
    1535                 1540                 1545             


Thr Gln  Pro Asn Thr Pro Ala  Pro Val Pro Pro Ala  Glu Asp Gly 
    1550                 1555                 1560             


Ile Lys  Ile Glu Glu Asn Ser  Leu Lys Glu Glu Glu  Ser Ile Glu 
    1565                 1570                 1575             


Gly Glu  Lys Glu Val Lys Ser  Thr Ala Pro Glu Thr  Ala Ile Glu 
    1580                 1585                 1590             


Cys Thr  Gln Ala Pro Ala Pro  Ala Ser Glu Asp Glu  Lys Val Val 
    1595                 1600                 1605             


Val Glu  Pro Pro Glu Gly Glu  Glu Lys Val Glu Lys  Ala Glu Val 
    1610                 1615                 1620             


Lys Glu  Arg Thr Glu Glu Pro  Met Glu Thr Glu Pro  Lys Gly Ala 
    1625                 1630                 1635             


Ala Asp  Val Glu Lys Val Glu  Glu Lys Ser Ala Ile  Asp Leu Thr 
    1640                 1645                 1650             


Pro Ile  Val Val Glu Asp Lys  Glu Glu Lys Lys Glu  Glu Glu Glu 
    1655                 1660                 1665             


Lys Lys  Glu Val Met Leu Gln  Asn Gly Glu Thr Pro  Lys Asp Leu 
    1670                 1675                 1680             


Asn Asp  Glu Lys Gln Lys Lys  Asn Ile Lys Gln Arg  Phe Met Phe 
    1685                 1690                 1695             


Asn Ile  Ala Asp Gly Gly Phe  Thr Glu Leu His Ser  Leu Trp Gln 
    1700                 1705                 1710             


Asn Glu  Glu Arg Ala Ala Thr  Val Thr Lys Lys Thr  Tyr Glu Ile 
    1715                 1720                 1725             


Trp His  Arg Arg His Asp Tyr  Trp Leu Leu Ala Gly  Ile Ile Asn 
    1730                 1735                 1740             


His Gly  Tyr Ala Arg Trp Gln  Asp Ile Gln Asn Asp  Pro Arg Tyr 
    1745                 1750                 1755             


Ala Ile  Leu Asn Glu Pro Phe  Lys Gly Glu Met Asn  Arg Gly Asn 
    1760                 1765                 1770             


Phe Leu  Glu Ile Lys Asn Lys  Phe Leu Ala Arg Arg  Phe Lys Leu 
    1775                 1780                 1785             


Leu Glu  Gln Ala Leu Val Ile  Glu Glu Gln Leu Arg  Arg Ala Ala 
    1790                 1795                 1800             


Tyr Leu  Asn Met Ser Glu Asp  Pro Ser His Pro Ser  Met Ala Leu 
    1805                 1810                 1815             


Asn Thr  Arg Phe Ala Glu Val  Glu Cys Leu Ala Glu  Ser His Gln 
    1820                 1825                 1830             


His Leu  Ser Lys Glu Ser Met  Ala Gly Asn Lys Pro  Ala Asn Ala 
    1835                 1840                 1845             


Val Leu  His Lys Val Leu Lys  Gln Leu Glu Glu Leu  Leu Ser Asp 
    1850                 1855                 1860             


Met Lys  Ala Asp Val Thr Arg  Leu Pro Ala Thr Ile  Ala Arg Ile 
    1865                 1870                 1875             


Pro Pro  Val Ala Val Arg Leu  Gln Met Ser Glu Arg  Asn Ile Leu 
    1880                 1885                 1890             


Ser Arg  Leu Ala Asn Arg Ala  Pro Glu Pro Thr Pro  Gln Gln Val 
    1895                 1900                 1905             


Ala Gln  Gln Gln 
    1910         


<210>  12
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  13
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Asp Lys Glu Ala Phe Asp Asp Ala Val Glu Glu Arg Val Ile 
1               5                   10                  15      


Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr Asp 
            20                  25                  30          


Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln Trp 
        35                  40                  45              


Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His Arg 
    50                  55                  60                  


Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val Ile 
65                  70                  75                  80  


Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser His 
                85                  90                  95      


Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser Gly 
            100                 105                 110         


Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn Arg 
        115                 120                 125             


Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr Pro 
    130                 135                 140                 


Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys Pro 
145                 150                 155                 160 


Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His Gln 
                165                 170                 175     


Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His Leu 
            180                 185                 190         


Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser Ala 
        195                 200                 205             


Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr Gly 
    210                 215                 220                 


His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu Ser 
225                 230                 235                 240 


Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp Thr 
                245                 250                 255     


Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His Thr 
            260                 265                 270         


Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile Leu 
        275                 280                 285             


Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg Asn 
    290                 295                 300                 


Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile Phe 
305                 310                 315                 320 


Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser Gly 
                325                 330                 335     


Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu Glu 
            340                 345                 350         


Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe Ile 
        355                 360                 365             


His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro Asn 
    370                 375                 380                 


Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln Val 
385                 390                 395                 400 


Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly Ser 
                405                 410                 415     


Val Asp Pro Glu Gly Gln Gly Ser 
            420                 


<210>  14
<211>  1792
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Cys Val His Tyr Lys Phe Ser Ser Lys Leu Asn Tyr Asp Thr 
1               5                   10                  15      


Val Thr Phe Asp Gly Leu His Ile Ser Leu Cys Asp Leu Lys Lys Gln 
            20                  25                  30          


Ile Met Gly Arg Glu Lys Leu Lys Ala Ala Asp Cys Asp Leu Gln Ile 
        35                  40                  45              


Thr Asn Ala Gln Thr Lys Glu Glu Tyr Thr Asp Asp Asn Ala Leu Ile 
    50                  55                  60                  


Pro Lys Asn Ser Ser Val Ile Val Arg Arg Ile Pro Ile Gly Gly Val 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Thr Tyr Val Ile Ser Arg Thr Glu Pro Ala Met 
                85                  90                  95      


Ala Thr Thr Lys Ala Ile Asp Asp Ser Ser Ala Ser Ile Ser Leu Ala 
            100                 105                 110         


Gln Leu Thr Lys Thr Ala Asn Leu Ala Glu Ala Asn Ala Ser Glu Glu 
        115                 120                 125             


Asp Lys Ile Lys Ala Met Met Ser Gln Ser Gly His Glu Tyr Asp Pro 
    130                 135                 140                 


Ile Asn Tyr Met Lys Lys Pro Leu Gly Pro Pro Pro Pro Ser Tyr Thr 
145                 150                 155                 160 


Cys Phe Arg Cys Gly Lys Pro Gly His Tyr Ile Lys Asn Cys Pro Thr 
                165                 170                 175     


Asn Gly Asp Lys Asn Phe Glu Ser Gly Pro Arg Ile Lys Lys Ser Thr 
            180                 185                 190         


Gly Ile Pro Arg Ser Phe Met Met Glu Val Lys Asp Pro Asn Met Lys 
        195                 200                 205             


Gly Ala Met Leu Thr Asn Thr Gly Lys Tyr Ala Ile Pro Thr Ile Asp 
    210                 215                 220                 


Ala Glu Ala Tyr Ala Ile Gly Lys Lys Glu Lys Pro Pro Phe Leu Pro 
225                 230                 235                 240 


Glu Glu Pro Ser Ser Ser Ser Glu Glu Asp Asp Pro Ile Pro Asp Glu 
                245                 250                 255     


Leu Leu Cys Leu Ile Cys Lys Asp Ile Met Thr Asp Ala Val Val Ile 
            260                 265                 270         


Pro Cys Cys Gly Asn Ser Tyr Cys Asp Glu Cys Ile Arg Thr Ala Leu 
        275                 280                 285             


Leu Glu Ser Asp Glu His Thr Cys Pro Thr Cys His Gln Asn Asp Val 
    290                 295                 300                 


Ser Pro Asp Ala Leu Ile Ala Asn Lys Phe Leu Arg Gln Ala Val Asn 
305                 310                 315                 320 


Asn Phe Lys Asn Glu Thr Gly Tyr Thr Lys Arg Leu Arg Lys Gln Leu 
                325                 330                 335     


Pro Pro Pro Pro Pro Pro Ile Pro Pro Pro Arg Pro Leu Ile Gln Arg 
            340                 345                 350         


Asn Leu Gln Pro Leu Met Arg Ser Pro Ile Ser Arg Gln Gln Asp Pro 
        355                 360                 365             


Leu Met Ile Pro Val Thr Ser Ser Ser Thr His Pro Ala Pro Ser Ile 
    370                 375                 380                 


Ser Ser Leu Thr Ser Asn Gln Ser Ser Leu Ala Pro Pro Val Ser Gly 
385                 390                 395                 400 


Asn Pro Ser Ser Ala Pro Ala Pro Val Pro Asp Ile Thr Ala Thr Val 
                405                 410                 415     


Ser Ile Ser Val His Ser Glu Lys Ser Asp Gly Pro Phe Arg Asp Ser 
            420                 425                 430         


Asp Asn Lys Ile Leu Pro Ala Ala Ala Leu Ala Ser Glu His Ser Lys 
        435                 440                 445             


Gly Thr Ser Ser Ile Ala Ile Thr Ala Leu Met Glu Glu Lys Gly Tyr 
    450                 455                 460                 


Gln Val Pro Val Leu Gly Thr Pro Ser Leu Leu Gly Gln Ser Leu Leu 
465                 470                 475                 480 


His Gly Gln Leu Ile Pro Thr Thr Gly Pro Val Arg Ile Asn Thr Ala 
                485                 490                 495     


Arg Pro Gly Gly Gly Arg Pro Gly Trp Glu His Ser Asn Lys Leu Gly 
            500                 505                 510         


Tyr Leu Val Ser Pro Pro Gln Gln Ile Arg Arg Gly Glu Arg Ser Cys 
        515                 520                 525             


Tyr Arg Ser Ile Asn Arg Gly Arg His His Ser Glu Arg Ser Gln Arg 
    530                 535                 540                 


Thr Gln Gly Pro Ser Leu Pro Ala Thr Pro Val Phe Val Pro Val Pro 
545                 550                 555                 560 


Pro Pro Pro Leu Tyr Pro Pro Pro Pro His Thr Leu Pro Leu Pro Pro 
                565                 570                 575     


Gly Val Pro Pro Pro Gln Phe Ser Pro Gln Phe Pro Pro Gly Gln Pro 
            580                 585                 590         


Pro Pro Ala Gly Tyr Ser Val Pro Pro Pro Gly Phe Pro Pro Ala Pro 
        595                 600                 605             


Ala Asn Leu Ser Thr Pro Trp Val Ser Ser Gly Val Gln Thr Ala His 
    610                 615                 620                 


Ser Asn Thr Ile Pro Thr Thr Gln Ala Pro Pro Leu Ser Arg Glu Glu 
625                 630                 635                 640 


Phe Tyr Arg Glu Gln Arg Arg Leu Lys Glu Glu Glu Lys Lys Lys Ser 
                645                 650                 655     


Lys Leu Asp Glu Phe Thr Asn Asp Phe Ala Lys Glu Leu Met Glu Tyr 
            660                 665                 670         


Lys Lys Ile Gln Lys Glu Arg Arg Arg Ser Phe Ser Arg Ser Lys Ser 
        675                 680                 685             


Pro Tyr Ser Gly Ser Ser Tyr Ser Arg Ser Ser Tyr Thr Tyr Ser Lys 
    690                 695                 700                 


Ser Arg Ser Gly Ser Thr Arg Ser Arg Ser Tyr Ser Arg Ser Phe Ser 
705                 710                 715                 720 


Arg Ser His Ser Arg Ser Tyr Ser Arg Ser Pro Pro Tyr Pro Arg Arg 
                725                 730                 735     


Gly Arg Gly Lys Ser Arg Asn Tyr Arg Ser Arg Ser Arg Ser His Gly 
            740                 745                 750         


Tyr His Arg Ser Arg Ser Arg Ser Pro Pro Tyr Arg Arg Tyr His Ser 
        755                 760                 765             


Arg Ser Arg Ser Pro Gln Ala Phe Arg Gly Gln Ser Pro Asn Lys Arg 
    770                 775                 780                 


Asn Val Pro Gln Gly Glu Thr Glu Arg Glu Tyr Phe Asn Arg Tyr Arg 
785                 790                 795                 800 


Glu Val Pro Pro Pro Tyr Asp Met Lys Ala Tyr Tyr Gly Arg Ser Val 
                805                 810                 815     


Asp Phe Arg Asp Pro Phe Glu Lys Glu Arg Tyr Arg Glu Trp Glu Arg 
            820                 825                 830         


Lys Tyr Arg Glu Trp Tyr Glu Lys Tyr Tyr Lys Gly Tyr Ala Ala Gly 
        835                 840                 845             


Ala Gln Pro Arg Pro Ser Ala Asn Arg Glu Asn Phe Ser Pro Glu Arg 
    850                 855                 860                 


Phe Leu Pro Leu Asn Ile Arg Asn Ser Pro Phe Thr Arg Gly Arg Arg 
865                 870                 875                 880 


Glu Asp Tyr Val Gly Gly Gln Ser His Arg Ser Arg Asn Ile Gly Ser 
                885                 890                 895     


Asn Tyr Pro Glu Lys Leu Ser Ala Arg Asp Gly His Asn Gln Lys Asp 
            900                 905                 910         


Asn Thr Lys Ser Lys Glu Lys Glu Ser Glu Asn Ala Pro Gly Asp Gly 
        915                 920                 925             


Lys Gly Asn Lys His Lys Lys His Arg Lys Arg Arg Lys Gly Glu Glu 
    930                 935                 940                 


Ser Glu Gly Phe Leu Asn Pro Glu Leu Leu Glu Thr Ser Arg Lys Ser 
945                 950                 955                 960 


Arg Glu Pro Thr Gly Val Glu Glu Asn Lys Thr Asp Ser Leu Phe Val 
                965                 970                 975     


Leu Pro Ser Arg Asp Asp Ala Thr Pro Val Arg Asp Glu Pro Met Asp 
            980                 985                 990         


Ala Glu Ser Ile Thr Phe Lys Ser  Val Ser Glu Lys Asp  Lys Arg Glu 
        995                 1000                 1005             


Arg Asp  Lys Pro Lys Ala Lys  Gly Asp Lys Thr Lys  Arg Lys Asn 
    1010                 1015                 1020             


Asp Gly  Ser Ala Val Ser Lys  Lys Glu Asn Ile Val  Lys Pro Ala 
    1025                 1030                 1035             


Lys Gly  Pro Gln Glu Lys Val  Asp Gly Glu Arg Glu  Arg Ser Pro 
    1040                 1045                 1050             


Arg Ser  Glu Pro Pro Ile Lys  Lys Ala Lys Glu Glu  Thr Pro Lys 
    1055                 1060                 1065             


Thr Asp  Asn Thr Lys Ser Ser  Ser Ser Ser Gln Lys  Asp Glu Lys 
    1070                 1075                 1080             


Ile Thr  Gly Thr Pro Arg Lys  Ala His Ser Lys Ser  Ala Lys Glu 
    1085                 1090                 1095             


His Gln  Glu Thr Lys Pro Val  Lys Glu Glu Lys Val  Lys Lys Asp 
    1100                 1105                 1110             


Tyr Ser  Lys Asp Val Lys Ser  Glu Lys Leu Thr Thr  Lys Glu Glu 
    1115                 1120                 1125             


Lys Ala  Lys Lys Pro Asn Glu  Lys Asn Lys Pro Leu  Asp Asn Lys 
    1130                 1135                 1140             


Gly Glu  Lys Arg Lys Arg Lys  Thr Glu Glu Lys Gly  Val Asp Lys 
    1145                 1150                 1155             


Asp Phe  Glu Ser Ser Ser Met  Lys Ile Ser Lys Leu  Glu Val Thr 
    1160                 1165                 1170             


Glu Ile  Val Lys Pro Ser Pro  Lys Arg Lys Met Glu  Pro Asp Thr 
    1175                 1180                 1185             


Glu Lys  Met Asp Arg Thr Pro  Glu Lys Asp Lys Ile  Ser Leu Ser 
    1190                 1195                 1200             


Ala Pro  Ala Lys Lys Ile Lys  Leu Asn Arg Glu Thr  Gly Lys Lys 
    1205                 1210                 1215             


Ile Gly  Ser Thr Glu Asn Ile  Ser Asn Thr Lys Glu  Pro Ser Glu 
    1220                 1225                 1230             


Lys Leu  Glu Ser Thr Ser Ser  Lys Val Lys Gln Glu  Lys Val Lys 
    1235                 1240                 1245             


Gly Lys  Val Arg Arg Lys Val  Thr Gly Thr Glu Gly  Ser Ser Ser 
    1250                 1255                 1260             


Thr Leu  Val Asp Tyr Thr Ser  Thr Ser Ser Thr Gly  Gly Ser Pro 
    1265                 1270                 1275             


Val Arg  Lys Ser Glu Glu Lys  Thr Asp Thr Lys Arg  Thr Val Ile 
    1280                 1285                 1290             


Lys Thr  Met Glu Glu Tyr Asn  Asn Asp Asn Thr Ala  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Ile Ile Met Ile Gln  Val Pro Gln Ser Lys  Trp Asp Lys 
    1310                 1315                 1320             


Asp Asp  Phe Glu Ser Glu Glu  Glu Asp Val Lys Ser  Thr Gln Pro 
    1325                 1330                 1335             


Ile Ser  Ser Val Gly Lys Pro  Ala Ser Val Ile Lys  Asn Val Ser 
    1340                 1345                 1350             


Thr Lys  Pro Ser Asn Ile Val  Lys Tyr Pro Glu Lys  Glu Ser Glu 
    1355                 1360                 1365             


Pro Ser  Glu Lys Ile Gln Lys  Phe Thr Lys Asp Val  Ser His Glu 
    1370                 1375                 1380             


Ile Ile  Gln His Glu Val Lys  Ser Ser Lys Asn Ser  Ala Ser Ser 
    1385                 1390                 1395             


Glu Lys  Gly Lys Thr Lys Asp  Arg Asp Tyr Ser Val  Leu Glu Lys 
    1400                 1405                 1410             


Glu Asn  Pro Glu Lys Arg Lys  Asn Ser Thr Gln Pro  Glu Lys Glu 
    1415                 1420                 1425             


Ser Asn  Leu Asp Arg Leu Asn  Glu Gln Gly Asn Phe  Lys Ser Leu 
    1430                 1435                 1440             


Ser Gln  Ser Ser Lys Glu Ala  Arg Thr Ser Asp Lys  His Asp Ser 
    1445                 1450                 1455             


Thr Arg  Ala Ser Ser Asn Lys  Asp Phe Thr Pro Asn  Arg Asp Lys 
    1460                 1465                 1470             


Lys Thr  Asp Tyr Asp Thr Arg  Glu Tyr Ser Ser Ser  Lys Arg Arg 
    1475                 1480                 1485             


Asp Glu  Lys Asn Glu Leu Thr  Arg Arg Lys Asp Ser  Pro Ser Arg 
    1490                 1495                 1500             


Asn Lys  Asp Ser Ala Ser Gly  Gln Lys Asn Lys Pro  Arg Glu Glu 
    1505                 1510                 1515             


Arg Asp  Leu Pro Lys Lys Gly  Thr Gly Asp Ser Lys  Lys Ser Asn 
    1520                 1525                 1530             


Ser Ser  Pro Ser Arg Asp Arg  Lys Pro His Asp His  Lys Ala Thr 
    1535                 1540                 1545             


Tyr Asp  Thr Lys Arg Pro Asn  Glu Glu Thr Lys Ser  Val Asp Lys 
    1550                 1555                 1560             


Asn Pro  Cys Lys Asp Arg Glu  Lys His Val Leu Glu  Ala Arg Asn 
    1565                 1570                 1575             


Asn Lys  Glu Ser Ser Gly Asn  Lys Leu Leu Tyr Ile  Leu Asn Pro 
    1580                 1585                 1590             


Pro Glu  Thr Gln Val Glu Lys  Glu Gln Ile Thr Gly  Gln Ile Asp 
    1595                 1600                 1605             


Lys Ser  Thr Val Lys Pro Lys  Pro Gln Leu Ser His  Ser Ser Arg 
    1610                 1615                 1620             


Leu Ser  Ser Asp Leu Thr Arg  Glu Thr Asp Glu Ala  Ala Phe Glu 
    1625                 1630                 1635             


Pro Asp  Tyr Asn Glu Ser Asp  Ser Glu Ser Asn Val  Ser Val Lys 
    1640                 1645                 1650             


Glu Glu  Glu Ser Ser Gly Asn  Ile Ser Lys Asp Leu  Lys Asp Lys 
    1655                 1660                 1665             


Ile Val  Glu Lys Ala Lys Glu  Ser Leu Asp Thr Ala  Ala Val Val 
    1670                 1675                 1680             


Gln Val  Gly Ile Ser Arg Asn  Gln Ser His Ser Ser  Pro Ser Val 
    1685                 1690                 1695             


Ser Pro  Ser Arg Ser His Ser  Pro Ser Gly Ser Gln  Thr Arg Ser 
    1700                 1705                 1710             


His Ser  Ser Ser Ala Ser Ser  Ala Glu Ser Gln Asp  Ser Lys Lys 
    1715                 1720                 1725             


Lys Lys  Lys Lys Lys Glu Lys  Lys Lys His Lys Lys  His Lys Lys 
    1730                 1735                 1740             


His Lys  Lys His Lys Lys His  Ala Gly Thr Glu Val  Glu Leu Glu 
    1745                 1750                 1755             


Lys Ser  Gln Lys His Lys His  Lys Lys Lys Lys Ser  Lys Lys Asn 
    1760                 1765                 1770             


Lys Asp  Lys Glu Lys Glu Lys  Glu Lys Asp Asp Gln  Lys Val Lys 
    1775                 1780                 1785             


Ser Val  Thr Val 
    1790         


<210>  15
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ala Glu Ala Gly Val Val Gly Ala Gly Ala Ser Pro Asp Gly 
1               5                   10                  15      


Asp Trp Arg Asp Gln Ala Cys Gly Leu Leu Leu His Val His Leu Ser 
            20                  25                  30          


Ser Arg Leu Gly Arg Ala Ala Pro Val Arg Thr Gly Arg His Leu Arg 
        35                  40                  45              


Thr Val Phe Glu Asp Thr Val Glu Glu Arg Val Ile Asn Glu Glu Tyr 
    50                  55                  60                  


Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr Asp Leu Val Met Thr 
65                  70                  75                  80  


His Ala Leu Gln Trp Pro Ser Leu Thr Val Gln Trp Leu Pro Glu Val 
                85                  90                  95      


Thr Lys Pro Glu Gly Lys Asp Tyr Ala Leu His Trp Leu Val Leu Gly 
            100                 105                 110         


Thr His Thr Ser Asp Glu Gln Asn His Leu Val Val Ala Arg Val His 
        115                 120                 125             


Ile Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser His Cys Asp Ser Asp 
    130                 135                 140                 


Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Thr Gly Lys Ile Glu Cys 
145                 150                 155                 160 


Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn Arg Ala Arg Tyr Met 
                165                 170                 175     


Pro Gln Asn Pro His Ile Ile Ala Thr Lys Thr Pro Ser Ser Asp Val 
            180                 185                 190         


Leu Val Phe Asp Tyr Thr Lys His Pro Ala Lys Pro Asp Pro Ser Gly 
        195                 200                 205             


Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His Gln Lys Glu Gly Tyr 
    210                 215                 220                 


Gly Leu Ser Trp Asn Ser Asn Leu Ser Gly His Leu Leu Ser Ala Ser 
225                 230                 235                 240 


Asp Asp His Thr Val Cys Leu Trp Asp Ile Asn Ala Gly Pro Lys Glu 
                245                 250                 255     


Gly Lys Ile Val Asp Ala Lys Ala Ile Phe Thr Gly His Ser Ala Val 
            260                 265                 270         


Val Glu Asp Val Ala Trp His Leu Leu His Glu Ser Leu Phe Gly Ser 
        275                 280                 285             


Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp Thr Arg Ser Asn Thr 
    290                 295                 300                 


Thr Ser Lys Pro Ser His Leu Val Asp Ala His Thr Ala Glu Val Asn 
305                 310                 315                 320 


Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile Leu Ala Thr Gly Ser 
                325                 330                 335     


Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg Asn Leu Lys Leu Lys 
            340                 345                 350         


Leu His Thr Phe Glu Ser His Lys Asp Glu Ile Phe Gln Val His Trp 
        355                 360                 365             


Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser Gly Thr Asp Arg Arg 
    370                 375                 380                 


Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu Glu Gln Ser Ala Glu 
385                 390                 395                 400 


Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe Ile His Gly Gly His 
                405                 410                 415     


Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro Asn Glu Pro Trp Val 
            420                 425                 430         


Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln Ile Trp Gln Met Ala 
        435                 440                 445             


Glu Asn Ile Tyr Asn Asp Glu Glu Ser Asp Val Thr Thr Ser Glu Leu 
    450                 455                 460                 


Glu Gly Gln Gly Ser 
465                 


<210>  16
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Gln Thr Gln Gly Thr Arg Arg Lys Val Cys Tyr Tyr Tyr Asp 
1               5                   10                  15      


Gly Asp Val Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys Pro 
            20                  25                  30          


His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu Tyr 
        35                  40                  45              


Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Asn Ala Glu Glu Met 
    50                  55                  60                  


Thr Lys Tyr His Ser Asp Asp Tyr Ile Lys Phe Leu Arg Ser Ile Arg 
65                  70                  75                  80  


Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn Val 
                85                  90                  95      


Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln Leu 
            100                 105                 110         


Ser Thr Gly Gly Ser Val Ala Ser Ala Val Lys Leu Asn Lys Gln Gln 
        115                 120                 125             


Thr Asp Ile Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys Lys 
    130                 135                 140                 


Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala Ile 
145                 150                 155                 160 


Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile Asp 
                165                 170                 175     


Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp Arg 
            180                 185                 190         


Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly Thr 
        195                 200                 205             


Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala Val 
    210                 215                 220                 


Asn Tyr Pro Leu Arg Asp Gly Ile Asp Asp Glu Ser Tyr Glu Ala Ile 
225                 230                 235                 240 


Phe Lys Pro Val Met Ser Lys Val Met Glu Met Phe Gln Pro Ser Ala 
                245                 250                 255     


Val Val Leu Gln Cys Gly Ser Asp Ser Leu Ser Gly Asp Arg Leu Gly 
            260                 265                 270         


Cys Phe Asn Leu Thr Ile Lys Gly His Ala Lys Cys Val Glu Phe Val 
        275                 280                 285             


Lys Ser Phe Asn Leu Pro Met Leu Met Leu Gly Gly Gly Gly Tyr Thr 
    290                 295                 300                 


Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala Leu 
305                 310                 315                 320 


Asp Thr Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu Tyr 
                325                 330                 335     


Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr Asn 
            340                 345                 350         


Gln Asn Thr Asn Glu Tyr Leu Glu Lys Ile Lys Gln Arg Leu Phe Glu 
        355                 360                 365             


Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala Ile 
    370                 375                 380                 


Pro Glu Asp Ala Ile Pro Glu Glu Ser Gly Asp Glu Asp Glu Asp Asp 
385                 390                 395                 400 


Pro Asp Lys Arg Ile Ser Ile Cys Ser Ser Asp Lys Arg Ile Ala Cys 
                405                 410                 415     


Glu Glu Glu Phe Ser Asp Ser Glu Glu Glu Gly Glu Gly Gly Arg Lys 
            420                 425                 430         


Asn Ser Ser Asn Phe Lys Lys Ala Lys Arg Val Lys Thr Glu Asp Glu 
        435                 440                 445             


Lys Glu Lys Asp Pro Glu Glu Lys Lys Glu Val Thr Glu Glu Glu Lys 
    450                 455                 460                 


Thr Lys Glu Glu Lys Pro Glu Ala Lys Gly Val Lys Glu Glu Val Lys 
465                 470                 475                 480 


Leu Ala 
        


<210>  17
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Tyr Ser Gln Gly Gly Gly Lys Lys Lys Val Cys Tyr Tyr Tyr 
1               5                   10                  15      


Asp Gly Asp Ile Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys 
            20                  25                  30          


Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu 
        35                  40                  45              


Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Thr Ala Glu Glu 
    50                  55                  60                  


Met Thr Lys Tyr His Ser Asp Glu Tyr Ile Lys Phe Leu Arg Ser Ile 
65                  70                  75                  80  


Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn 
                85                  90                  95      


Val Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln 
            100                 105                 110         


Leu Ser Thr Gly Gly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln 
        115                 120                 125             


Gln Thr Asp Met Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys 
    130                 135                 140                 


Lys Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala 
145                 150                 155                 160 


Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile 
                165                 170                 175     


Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp 
            180                 185                 190         


Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly 
        195                 200                 205             


Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala 
    210                 215                 220                 


Val Asn Phe Pro Met Arg Asp Gly Ile Asp Asp Glu Ser Tyr Gly Gln 
225                 230                 235                 240 


Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu Met Tyr Gln Pro Ser 
                245                 250                 255     


Ala Val Val Leu Gln Cys Gly Ala Asp Ser Leu Ser Gly Asp Arg Leu 
            260                 265                 270         


Gly Cys Phe Asn Leu Thr Val Lys Gly His Ala Lys Cys Val Glu Val 
        275                 280                 285             


Val Lys Thr Phe Asn Leu Pro Leu Leu Met Leu Gly Gly Gly Gly Tyr 
    290                 295                 300                 


Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala 
305                 310                 315                 320 


Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu 
                325                 330                 335     


Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr 
            340                 345                 350         


Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe 
        355                 360                 365             


Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala 
    370                 375                 380                 


Ile Pro Glu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu 
385                 390                 395                 400 


Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala 
                405                 410                 415     


Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg 
            420                 425                 430         


Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu 
        435                 440                 445             


Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys Glu Glu 
    450                 455                 460                 


Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr Lys Gly Thr 
465                 470                 475                 480 


Lys Ser Glu Gln Leu Ser Asn Pro 
                485             


<210>  18
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn 
1               5                   10                  15      


Ser Ser Ser Asn Pro Tyr Leu Ile Arg Arg Ile Glu Glu Leu Asn Lys 
            20                  25                  30          


Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Phe Tyr Arg Arg 
        35                  40                  45              


Arg Asp Ile Ser Ser Thr Leu Ile Ala Leu Ala Asp Lys His Ala Thr 
    50                  55                  60                  


Leu Ser Val Cys Tyr Lys Ala Gly Pro Gly Ala Asp Asn Gly Glu Glu 
65                  70                  75                  80  


Gly Glu Ile Glu Glu Glu Met Glu Asn Pro Glu Met Val Asp Leu Pro 
                85                  90                  95      


Glu Lys Leu Lys His Gln Leu Arg His Arg Glu Leu Phe Leu Ser Arg 
            100                 105                 110         


Gln Leu Glu Ser Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val 
        115                 120                 125             


Thr Leu Leu Asn Glu Thr Glu Ser Leu Lys Ser Tyr Leu Glu Arg Glu 
    130                 135                 140                 


Asp Phe Phe Phe Tyr Ser Leu Val Tyr Asp Pro Gln Gln Lys Thr Leu 
145                 150                 155                 160 


Leu Ala Asp Lys Gly Glu Ile Arg Val Gly Asn Arg Tyr Gln Ala Asp 
                165                 170                 175     


Ile Thr Asp Leu Leu Lys Glu Gly Glu Glu Asp Gly Arg Asp Gln Ser 
            180                 185                 190         


Arg Leu Glu Thr Gln Val Trp Glu Ala His Asn Pro Leu Thr Asp Lys 
        195                 200                 205             


Gln Ile Asp Gln Phe Leu Val Val Ala Arg Ser Val Gly Thr Phe Ala 
    210                 215                 220                 


Arg Ala Leu Asp Cys Ser Ser Ser Val Arg Gln Pro Ser Leu His Met 
225                 230                 235                 240 


Ser Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp 
                245                 250                 255     


Thr Leu His Lys Asn Ile Tyr Asp Ile Ser Lys Ala Ile Ser Ala Leu 
            260                 265                 270         


Val Pro Gln Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp 
        275                 280                 285             


Ser Ala Ser Glu Ala Asn Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly 
    290                 295                 300                 


Lys Asp Phe Thr Asp Ile Gln Gln Asp Phe Leu Pro Trp Lys Ser Leu 
305                 310                 315                 320 


Thr Ser Ile Ile Glu Tyr Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr 
                325                 330                 335     


Val Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Glu Ser Lys Leu Lys 
            340                 345                 350         


Gln Val Tyr Ile Pro Asn Tyr Asn Lys Pro Asn Pro Asn Gln Ile Ser 
        355                 360                 365             


Val Asn Asn Val Lys Ala Gly Val Val Asn Gly Thr Gly Ala Pro Gly 
    370                 375                 380                 


Gln Ser Pro Gly Ala Gly Arg Ala Cys Glu Ser Cys Tyr Met Ser Ser 
385                 390                 395                 400 


Leu Arg Ile Leu Leu Asp Ile Leu Glu Glu Ile Trp Trp Leu Glu Asn 
                405                 410                 415     


Ala Asn Pro Val Arg Trp Arg Glu Ala Arg Thr Lys Pro Gln 
            420                 425                 430 


<210>  19
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn 
1               5                   10                  15      


Ser Ser Ser Asn Pro Tyr Leu Val Arg Arg Ile Glu Glu Leu Asn Lys 
            20                  25                  30          


Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Leu Phe Arg Arg 
        35                  40                  45              


Arg Asp Ile Ser Ser Ser Leu Asn Ser Leu Ala Asp Ser Asn Ala Arg 
    50                  55                  60                  


Glu Phe Glu Glu Glu Ser Lys Gln Pro Gly Val Ser Glu Gln Gln Arg 
65                  70                  75                  80  


His Gln Leu Lys His Arg Glu Leu Phe Leu Ser Arg Gln Phe Glu Ser 
                85                  90                  95      


Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val Thr Leu Leu Asn 
            100                 105                 110         


Glu Thr Asp Ile Leu Ser Gln Tyr Leu Glu Lys Glu Asp Cys Phe Phe 
        115                 120                 125             


Tyr Ser Leu Val Phe Asp Pro Val Gln Lys Thr Leu Leu Ala Asp Gln 
    130                 135                 140                 


Gly Glu Ile Arg Val Gly Cys Lys Tyr Gln Ala Glu Ile Pro Asp Arg 
145                 150                 155                 160 


Leu Val Glu Gly Glu Ser Asp Asn Arg Asn Gln Gln Lys Met Glu Met 
                165                 170                 175     


Lys Val Trp Asp Pro Asp Asn Pro Leu Thr Asp Arg Gln Ile Asp Gln 
            180                 185                 190         


Phe Leu Val Val Ala Arg Ala Val Gly Thr Phe Ala Arg Ala Leu Asp 
        195                 200                 205             


Cys Ser Ser Ser Ile Arg Gln Pro Ser Leu His Met Ser Ala Ala Ala 
    210                 215                 220                 


Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp Thr Leu Gln Arg 
225                 230                 235                 240 


Asn Gly Tyr Asp Leu Ala Lys Ala Met Ser Thr Leu Val Pro Gln Gly 
                245                 250                 255     


Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp Ser Ala Ser Glu 
            260                 265                 270         


Ala Met Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly Lys Asp Phe Asn 
        275                 280                 285             


Asp Ile Arg Gln Asp Phe Leu Pro Trp Lys Ser Leu Ala Ser Ile Val 
    290                 295                 300                 


Gln Phe Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr Ile Gln Gln Lys 
305                 310                 315                 320 


Arg Leu Lys Ala Ala Glu Ala Asp Ser Lys Leu Lys Gln Val Tyr Ile 
                325                 330                 335     


Pro Thr Tyr Thr Lys Pro Asn Pro Asn Gln Ile Ile Ser Val Gly Ser 
            340                 345                 350         


Lys Pro Gly Met Asn Gly Ala Gly Phe Gln Lys Gly Leu Thr Cys Glu 
        355                 360                 365             


Ser Cys His Thr Thr Gln Ser Ala Gln Trp Tyr Ala Trp Gly Pro Pro 
    370                 375                 380                 


Asn Met Gln Cys Arg Leu Cys Ala Ser Cys Trp Ile Tyr Trp Lys Lys 
385                 390                 395                 400 


Tyr Gly Gly Leu Lys Thr Pro Thr Gln Leu Glu Gly Ala Thr Arg Gly 
                405                 410                 415     


Thr Thr Glu Pro His Ser Arg Gly His Leu Ser Arg Pro Glu Ala Gln 
            420                 425                 430         


Ser Leu Ser Pro Tyr Thr Thr Ser Ala Asn Arg Ala Lys Leu Leu Ala 
        435                 440                 445             


Lys Asn Arg Gln Thr Phe Leu Leu Gln Thr Thr Lys Leu Thr Arg Leu 
    450                 455                 460                 


Ala Arg Arg Met Cys Arg Asp Leu Leu Gln Pro Arg Arg Ala Ala Arg 
465                 470                 475                 480 


Arg Pro Tyr Ala Pro Ile Asn Ala Asn Ala Ile Lys Ala Glu Cys Ser 
                485                 490                 495     


Ile Arg Leu Pro Lys Ala Ala Lys Thr Pro Leu Lys Ile His Pro Leu 
            500                 505                 510         


Val Arg Leu Pro Leu Ala Thr Ile Val Lys Asp Leu Val Ala Gln Ala 
        515                 520                 525             


Pro Leu Lys Pro Lys Thr Pro Arg Gly Thr Lys Thr Pro Ile Asn Arg 
    530                 535                 540                 


Asn Gln Leu Ser Gln Asn Arg Gly Leu Gly Gly Ile Met Val Lys Arg 
545                 550                 555                 560 


Ala Tyr Glu Thr Met Ala Gly Ala Gly Val Pro Phe Ser Ala Asn Gly 
                565                 570                 575     


Arg Pro Leu Ala Ser Gly Ile Arg Ser Ser Ser Gln Pro Ala Ala Lys 
            580                 585                 590         


Arg Gln Lys Leu Asn Pro Ala Asp Ala Pro Asn Pro Val Val Phe Val 
        595                 600                 605             


Ala Thr Lys Asp Thr Arg Ala Leu Arg Lys Ala Leu Thr His Leu Glu 
    610                 615                 620                 


Met Arg Arg Ala Ala Arg Arg Pro Asn Leu Pro Leu Lys Val Lys Pro 
625                 630                 635                 640 


Thr Leu Ile Ala Val Arg Pro Pro Val Pro Leu Pro Ala Pro Ser His 
                645                 650                 655     


Pro Ala Ser Thr Asn Glu Pro Ile Val Leu Glu Asp 
            660                 665             


<210>  20
<211>  19296
<212>  DNA
<213>  Homo sapiens

<400>  20
ccttcagttc ttaaagcgct gcaattcgct gctgcagcca tatttcttac tctctcgggg       60

ctggaagctt cctgactgaa gatctctctg cacttggggt tctttctaga acattttcta      120

gtcccccaac accctttatg gcgtatttct ttaaaaaaat cacctaaatt ccataaaata      180

tttttttaaa ttctatactt tctcctagtg tcttcttgac acgtcctcca tattttttta      240

aagaaagtat ttggaatatt ttgaggcaat ttttaatatt taaggaattt ttctttggaa      300

tcatttttgg ttgacatctc tgttttttgt ggatcagttt tttactcttc cactctcttt      360

tctatatttt gcccatcggg gctgcggata cctggtttta ttattttttc tttgcccaac      420

ggggccgtgg atacctgcct tttaattctt ttttattcgc ccatcggggc cgcggatacc      480

tgctttttat ttttttttcc ttagcccatc ggggtatcgg atacctgctg attcccttcc      540

cctctgaacc cccaacactc tggcccatcg gggtgacgga tatctgcttt ttaaaaattt      600

tctttttttg gcccatcggg gcttcggata cctgcttttt ttttttttat ttttccttgc      660

ccatcggggc ctcggatacc tgctttaatt tttgtttttc tggcccatcg gggccgcgga      720

tacctgcttt gatttttttt tttcatcgcc catcggtgct ttttatggat gaaaaaatgt      780

tggttttgtg ggttgttgca ctctctggaa tatctacact tttttttgct gctgatcatt      840

tggtggtgtg tgagtgtacc taccgctttg gcagagaatg actctgcagt taagctaagg      900

gcgtgttcag attgtggagg aaaagtggcc gccattttag acttgccgca taactcggct      960

tagggctagt cgtttgtgct aagttaaact agggaggcaa gatggatgat agcaggtcag     1020

gcagaggaag tcatgtgcat tgcatgagct aaacctatct gaatgaattg atttggggct     1080

tgttaggagc tttgcgtgat tgttgtatcg ggaggcagta agaatcatct tttatcagta     1140

caagggacta gttaaaaatg gaaggttagg aaagactaag gtgcagggct taaaatggcg     1200

attttgacat tgcggcattg ctcagcatgg cgggctgtgc tttgttaggt tgtccaaaat     1260

ggcggatcca gttctgtcgc agtgttcaag tggcgggaag gccacatcat gatgggcgag     1320

gctttgttaa gtggttagca tggtggtgga catgtgcggt cacacaggaa aagatggcgg     1380

ctgaaggtct tgccgcagtg taaaacatgg cgggcctctt tgtctttgct gtgtgctttt     1440

cgtgttgggt tttgccgcag ggacaatatg gcaggcgttg tcatatgtat atcatggctt     1500

ttgtcacgtg gacatcatgg cgggcttgcc gcattgttaa agatggcggg ttttgccgcc     1560

tagtgccacg cagagcggga gaaaaggtgg gatggacagt gctggattgc tgcataaccc     1620

aaccaattag aaatgggggt ggaattgatc acagccaatt agagcagaag atggaattag     1680

actgatgaca cactgtccag ctactcagcg aagacctggg tgaattagca tggcacttcg     1740

cagctgtctt tagccagtca ggagaaagaa gtggaggggc cacgtgtatg tctcccagtg     1800

ggcggtacac caggtgtttt caaggtcttt tcaaggacat ttagcctttc cacctctgtc     1860

ccctcttatt tgtcccctcc tgtccagtgc tgcctcttgc agtgctggat atctggctgt     1920

gtggtctgaa cctccctcca ttcctctgta ttggtgcctc acctaaggct aagtatacct     1980

ccccccccac cccccaaccc ccccaactcc ccacccccac cccccacccc ccacctcccc     2040

acccccctac ccccctaccc ccctaccccc ctctggtctg ccctgcactg cactgttgcc     2100

atgggcagtg ctccaggcct gcttggtgtg gacatggtgg tgagccgtgg caaggaccag     2160

aatggatcac agatgatcgt tggccaacag gtggcagaag aggaattcct gccttcctca     2220

agaggaacac ctaccccttg gctaatgctg gggtcggatt ttgatttata tttatctttt     2280

ggatgtcagt catacagtct gattttgtgg tttgctagtg tttgaattta agtcttaagt     2340

gactattata gaaatgtatt aagaggcttt atttgtagaa ttcactttaa ttacatttaa     2400

tgagtttttg ttttgagttc cttaaaattc cttaaagttt ttagcttctc attacaaatt     2460

ccttaacctt tttttggcag tagatagtca aagtcaaatc atttctaatg ttttaaaaat     2520

gtgctggtca ttttctttga aattgactta actattttcc tttgaagagt ctgtagcaca     2580

gaaacagtaa aaaatttaac ttcatgacct aatgtaaaaa agagtgtttg aaggtttaca     2640

caggtccagg ccttgctttg ttcccatcct tgatgctgca ctaattgact aatcacctac     2700

ttatcagaca ggaaacttga attgctgtgg tctggtgtcc tctattcaga cttattatat     2760

tggagtattt caatttttcg ttgtatcctg cctgcctagc atccagttcc tccccagccc     2820

tgctcccagc aaacccctag tctagcccca gccctactcc caccccgccc cagccctgcc     2880

ccagccccag tcccctaacc ccccagccct agccccagtc ccagtcctag ttcctcagtc     2940

ccgcccagct tctctcgaaa gtcactctaa ttttcattga ttcagtgctc aaaataagtt     3000

gtccattgct tatcctatta tactgggata ttccgtttac ccttggcatt gctgatcttc     3060

agtactgact ccttgaccat tttcagttaa tgcatacaat cccatttgtc tgtgatctca     3120

ggacaaagaa tttccttact cggtacgttg aagttaggga atgtcaattg agagctttct     3180

atcagagcat tattgcccac aatttgagtt acttatcatt ttctcgatcc cctgccctta     3240

aaggagaaac catttctctg tcattgcttc tgtagtcaca gtcccaattt tgagtagtga     3300

tcttttcttg tgtactgtgt tggccaccta aaactctttg cattgagtaa aattctaatt     3360

gccaataatc ctacccattg gattagacag cactctgaac cccatttgca ttcagcaggg     3420

ggtcgcagac aacccgtctt ttgttggaca gttaaaatgc tcagtcccaa ttgtcatagc     3480

tttgcctatt aaacaaaggc accctactgc gctttttgct gtgcttctgg agaatcctgc     3540

tgttcttgga caattaaaga acaaagtagt aattgctaat tgtctcaccc attaatcatg     3600

aagactacca gtcgcccttg catttgcctt gaggcagcgc tgactacctg agatttaaga     3660

gtttcttaaa ttattgagta aaatcccaat tatccatagt tctgttagtt acactatggc     3720

ctttgcaaac atctttgcat aacagcagtg ggactgactc attcttagag ccccttccct     3780

tggaatatta atggatacaa tagtaattat tcatggttct gcgtaacaga gaagacccac     3840

ttatgtgtat gcctttatca ttgctcctag atagtgtgaa ctacctacca ccttgcatta     3900

atatgtaaaa cactaattgc ccatagtccc actcattagt ctaggatgtc ctctttgcca     3960

ttgctgctga gttctgacta cccaagtttc cttctcttaa acagttgata tgcataattg     4020

catatattca tggttctgtg caataaaaat ggattctcac cccatcccac cttctgtggg     4080

atgttgctaa cgagtgcaga ttattcaata acagctcttg aacagttaat ttgcacagtt     4140

gcaattgtcc agagtcctgt ccattagaaa gggactctgt atcctatttg cacgctacaa     4200

tgtgggctga tcacccaagg actcttcttg tgcattgatg ttcataattg tatttgtcca     4260

cgatcttgtg cactaaccct tccactccct ttgtattcca gcaggggacc cttactactc     4320

aagacctctg tactaggaca gtttatgtgc acaatcctaa ttgattagaa ctgagtcttt     4380

tatatcaagg tccctgcatc atctttgctt tacatcaaga gggtgctggt tacctaatgc     4440

ccctcctcca gaaattattg atgtgcaaaa tgcaatttcc ctatctgctg ttagtctggg     4500

gtctcatccc ctcatattcc ttttgtctta cagcaggggg tacttgggac tgttaatgcg     4560

cataattgca attatggtct tttccattaa attaagatcc caactgctca caccctctta     4620

gcattacagt agagggtgct aatcacaagg acatttcttt tgtactgtta atgtgctact     4680

tgcatttgtc cctcttcctg tgcactaaag accccactca cttccctagt gttcagcagt     4740

ggatgacctc tagtcaagac ctttgcacta ggatagttaa tgtgaaccat ggcaactgat     4800

cacaacaatg tctttcagat cagatccatt ttatcctcct tgttttacag caagggatat     4860

taattaccta tgttaccttt ccctgggact atgaatgtgc aaaattccaa tgttcatggt     4920

ctctcccttt aaacctatat tctacccctt ttacattata gaaagggatg ctggaaaccc     4980

agagtccttc tcttgggact cttaatgtgt atttctaatt atccatgact cttaatgtgc     5040

atattttcaa ttgcctaatt gatttcaatt gtctaagaca tttcaaatgt ctaattgatt     5100

agaactgagt cttttatatc aagctaatat ctagctttta tatcaagcta atatcttgac     5160

ttctcagcat catagaaggg ggtactgatt tcctaaagtc tttcttgaat ttctattatg     5220

caaaattgcc ctgaggccgg gtgtggtggc tcacacctgt aatcccagca ctttgggagg     5280

ctgaggtggg aagatccctt actgccagga gtttgagacc agcctggcca acattaaaaa     5340

aaaaaaaaag taagacaatt gccctggaat cccatccccc tcacacctcc ttggcaaagc     5400

agcaggagtg ctaactagct agtgcttctt ctcttatact gcttaaatgc gcataattag     5460

cagtagttga tgtgccccta tgttagagta gaatcccgct tccttgctcc atttgcatta     5520

ctgcaggagc ttctaactag cctgaattca ctctcttgga ctgttaatgt gcatacttat     5580

atttgctgct gtactttttt accatgtaag gaccccaccc actgtattta catcccagct     5640

ggaagtacct actacttaag acccttagac tagtaaagtt agcgtgcata atcttaggtg     5700

ttatatacac attttcagtt gcatacagtt gtgcctttta tcaggactcc tgtacttatc     5760

aaagcagaga gtgctaatca atattaagcc cttctcttcg aactgtagat ggcatgtaat     5820

tgcagttgtc aatggtcctt caattagact tgggtttctg acctatcaca ccctctttgc     5880

tttattgcat ggggtactat tcacttaagg cccctttctc aaactgttaa tgtgcctaat     5940

gacaattaca tcagtatcct tccttttgaa ggacagcatg gttggtgaca cctaaggccc     6000

catttcttgg cctcccaata tgtgtgattg tatttgtcga ggttgctatg cactagagaa     6060

ggaaagtgct cccctcatcc ccacttttcc cttccagcag gaagtgccca ccccataaga     6120

cccttttatt tggagagtct aggtgcacaa ttgtaagtga ccacaagcat gcatcttgga     6180

catttatgtg cgtaatcgca cactgctcat tccatgtgaa taaggtccta ctctccgacc     6240

ccttttgcaa tacagaaggg ttgctgataa cgcagtcccc ttttcttggc atgttgtgtg     6300

tgattataat cgtctgggat cctatgcact agaaaaggag ggtcctctcc acatacctca     6360

gtctcacctt tcccttccag cagggagtgc ccactccata agactctcac atttggacag     6420

tcaaggtgcg taattgttaa gtgaacacaa ccatgcacct tagacatgga tttgcataac     6480

tacacacagc tcaacctatc tgaataaaat cctactctca gacccctttt gcagtacagc     6540

aggggtgctg atcaccaagg ccctttttcc tggcctggta tgcgtgtgat tatgtttgtc     6600

ccggttcctg tgtattagac atggaagcct cccctgccac actccacccc caatcttcct     6660

ttcccttccg gcagggagtg ccctctccat aagacgctta cgtttggaca atcaaggtgc     6720

acagttgtaa gtgaccacag gcatacacct tggacattaa tgtgcataac cactttgccc     6780

attccatctg aataaggtcc tactctcaga ccccttttgc agtacagcag gggtgctgat     6840

caccaaggcc ccttttcttg gcctgttatg tgcgtgatta tatttgtctg ggttcctgtg     6900

tattagacaa ggaagccttc cccccgcccc cacccccact cccagtcttc ctttcccttc     6960

cagcagggag tgccccctcc ataagatcat tacatttgga caatcaaggt gcacaattat     7020

aagtgaccac agccatgcac cttggacatt attggacatt aatgtgcgta actgcacatg     7080

gcccatccca tctgaataag gtcctactct cagatgccct ttgcagtaca gcaggggtac     7140

tgaatcacca aggccctttt tcttggcctg ttatgtgtgt gattatattt atcccagttt     7200

ctgtgtaata gacatgaaag cctcccctgc cacaccccac ctccaatctt cctttccctt     7260

ccaccaggga gtgtccactc catataccct tacatttgga caatcaaggt gcacaattgt     7320

aagtgagcat aggcactcac cttggacatg aatgtgcata actgcacatg gcccatccca     7380

tctgaataag gtcctactct cagacccttt ttgcagtaca gcaggggtgc tgatcaccaa     7440

ggcccctttt cctggcctgt tatgtgtgtg attatatttg ttccagttcc tgtgtaatag     7500

acatggaagc ctcccctgcc acactccacc cccaatcttc ctttcccttc tggcaggaag     7560

tacccgctcc ataagaccct tacatttgga cagtcaaggt gcacaattgt atgtgaccac     7620

aaccatgcac cttggacata aatgtgtgta actgcacatg gcccatccca tctgaataag     7680

gtcctactct cagacccctt ttgcagtaca gtaggtgtgc tgataaccaa ggcccctctt     7740

cctggcctgt taacgtatgt gattatattt gtctgggttc cagtgtataa gacatggaag     7800

cctcccctgc cccaccccac cctcaatctt cctttccctt ctggcaggga gtgccagctc     7860

cataagaacc ttacatttgg acagtcaagg tgcacaattc taagtgaccg cagccatgca     7920

ccttggtcaa taatgtgtgt aactgcacac ggcctatctc atctgaataa ggccttactc     7980

tcagacccct tttgcagtac agcaggggtg ctgataacca aggcccattt tcctggcctg     8040

ttatgtgtgt gattatattt gtccaggttt ctgtgtacta gacaaggaag cctcctctgc     8100

cccatcccat ctacgcataa tctttctttt cctcccagca gggagtgctc actccataag     8160

acccttacat ttggacaatc aaggtgcaca attgtaagtg accacaacca tgcatcttgg     8220

aaatttatgt gcataactgc acatggctta tcctatttga ataaagtcct actctcagac     8280

cccctttgca gtatagctgg ggtgctgatc actgaggcct ctttgcttgg cttgtctata     8340

ttcttgtgta ctagataagg gcaccttctc atggactccc tttgcttttc aacaaggagt     8400

acccactact ttttaagatt cttatatttg tccaaagtac atggttttaa ttgaccacaa     8460

caatgtccct tggacattaa tgtatgtaat caccacatgg ttcatcctaa ttaaacaaag     8520

ttctaccttc tcaccctcca tttgcagtat accagggttg ctgaccccct aagtcccctt     8580

ttcttggctt gttgacatgc ataattgcat ttatgttggt tcttgtgccc tagacaagga     8640

tgccccacct cttttcaata gtgggtgccc actccttatg atctttacat ttgaacagtt     8700

aatgtgaata attgcagttg tccacaaccc tatcacttct aggaccatta tacctctttt     8760

gcattactgt ggggtatact gtttccctcc aaggcccctt ctggtggact atcaacatat     8820

aattgaaatt ttcttttgtc tttgtcagta gattaaggtc ataccccatc acctttcctt     8880

tgtagtacaa cagggtgtcc tgatcaacca aagtcctgtt gttttggact gttaatatgt     8940

gcaattacat ttgctcctga tctgtgcact agataaggat cctacctact ttcttagtgt     9000

ttttagcagg tagtgcccac tactcaagac tgtcacttgg aatgttcatg tgcacaaact     9060

caattctcta agcatgttcc tgtaccacct ttgctttaga gcagggggat gatattcact     9120

aagtgcccct tcttttggac ttaatatgca ttaatgcaat tgtccacctc ttcttttaga     9180

ctaagagttg atctccacat attccccttg catcaggggc atgttaatta tgaatgaacc     9240

cttttctttt aatattaatg tcataattgt atttgtggac ctgtgtagga gaaaaagacc     9300

ctatgttcct cccattaccc tttggattgc tgctgagaag tgttaactac tcataatctc     9360

agctcttgga caattaatag cattaataac aattatcaag ggcactgatc attagataag     9420

actcctgctt cctcgttgct tacatcgggg gtactgaccc actaaggccc cttgtactgt     9480

taatgtgaat atttgcaatt atatatgtct ccttctggta gagtgggata ttatgcccta     9540

gtatcccctt tgcattactg caggggctgc tgactactca aaacttctcc tgggactgtt     9600

aataggcaca atggcagtta tcaatggttt tctccctccc tgaccttgtt aagcaagcgc     9660

cccaccccac ccttagtttc ccatggcata ataaagtata agcattggag tattccatgc     9720

acttgtctat caaacagtgg tccatactcc caaccctttt gcattgcgcc agtgtgtaaa     9780

atcacaggta gccatggtgt catgctttat atacgaagtc ttccctctct ctgccccttg     9840

tgtgcccttg gccccttttt acagactatt gctcacaatc tcaggtgtcc atatttgcag     9900

ctattaggta agattgtgct gtctccctct tcccttccct ctgccctgcc ccttttgcct     9960

ctttgctggg taatgttgac cagacaaggc cctttctctt ggacttaaac aattctcagt    10020

tgcactttcc ttggtcccac ccattataca tgaacccctc tacttccttt cgcattgctt    10080

ctgagtatgc tgactaccca aagccccttc tgtgttatta ataaacacag tactgattgt    10140

cccatttttc agcccatcag tccaagatct ccctaccact ttggtgtgtt ggtgcagtgt    10200

tgactatgaa aagcaggcct gaactaggtg gataagcctt cactcatttt ctttcattta    10260

ttaatgatcc tagtttcaat tattgtcaga ttctggggac aagaaccatt cttgcccacc    10320

tgtgttactg ctttactgtg caaaatactg aaggcaagtc agacccaggg agctggattg    10380

ccatccttta ttttgtgttt ccagtgtaca ctataaaatt gtctccccag gaaggaaggt    10440

tggcactttc tctgcattct tctttccaga gcagattgcc tggttaagaa tctcttgttg    10500

tcccctttgt atattgttat tgtaaagtgc caaatgccag gatacagcca gaaaaattgc    10560

ttattattat taaaaaaatt tttttaagaa agacatctgg attgtagggt ggactcgata    10620

acctggtcat tatttttttg aagccaaaat atccatttat actatgtacc tggtgaccag    10680

tgtctctcat tttaactgag ggtggtgggt ctgtggatag aacactgact cttgctattt    10740

taatatcaaa gatattctag agtggaactc ttaagaccag tatctttgtg tgggctttac    10800

cagcattcac ttttagaaaa actacctaaa ttttataatc ctttaatttc ttcatctgga    10860

gcacctgccc ctacttattt caagaagatt gcagtaaaac gattaaatga gggaacatat    10920

gcagaggtgc ttttaaaaag catatgccac cttttttatt aattattata taaaatgaag    10980

catttaatta tagtaataat ttgaagtagt ttgaagtacc acactgaggt gaggacttaa    11040

aaatgataag acgagttccc tattttataa gaaaaataag ccaaaattaa atattctttt    11100

ggatataaat ttcaacagtg agatagctgc ctagtggaaa tgaataatat cccagccact    11160

agtgtacagg gtgttttgtg gcacaggatt atgtaatatg gaactgctca agcaaataac    11220

tagtcatcac aacagcagtt ctttgtaata actgaaaaag aatattgttt ctcggagaag    11280

gatgtcaaaa gatcggccca gctcagggag cagtttgccc tactagctcc tcggacagct    11340

gtaaagaaga gtctctggct ctttagaata ctgatcccat tgaagatacc acgctgcatg    11400

tgtccttagt agtcatgtct ccttaggctc ctcttggaca ttctgagcat gtgagacctg    11460

aggactgcaa acagctataa gaggctccaa attaatcata tctttccctt tgagaatctg    11520

gccaagctcc agctaatcta cttggatggg ttgccagcta tctggagaaa aagatcttcc    11580

tcagaagaat aggcttgttg ttttacagtg ttagtgatcc attccctttg acgatcccta    11640

ggtggagatg gggcatgagg atcctccagg ggaaaagctc actaccactg ggcaacaacc    11700

ctaggtcagg aggttctgtc aagatacttt cctggtccca gataggaaga taaagtctca    11760

aaaacaacca ccacacgtca agctcttcat tgttcctatc tgccaaatca ttatacttcc    11820

tacaagcagt gcagagagct gagtcttcag caggtccaag aaatttgaac acactgaagg    11880

aagtcagcct tcccacctga agatcaacat gcctggcact ctagcacttg aggatagctg    11940

aatgaatgtg tatttctttg tctctttctt tcttgtcttt gctctttgtt ctctatctaa    12000

agtgtgtctt acccatttcc atgtttctct tgctaatttc tttcgtgtgt gcctttgcct    12060

cattttctct ttttgttcac aagagtggtc tgtgtcttgt cttagacata tctctcattt    12120

ttcattttgt tgctatttct ctttgctctc ctagatgtgg ctcttctttc acgctttatt    12180

tcatgtctcc tttttgggtc acatgctgtg tgctttttgt ccttttcttg ttctgtctac    12240

ctctcctttc tctgcctacc tctcttttct ctttgtgaac tgtgattatt tgttacccct    12300

tccccttctc gttcgtttta aatttcacct tttttctgag tctggcctcc tttctgctgt    12360

ttctactttt tatctcacat ttctcatttc tgcatttcct ttctgcctct cttgggctat    12420

tctctctctc ctcccctgcg tgcctcagca tctcttgctg tttgtgattt tctatttcag    12480

tattaatctc tgttggcttg tatttgttct ctgcttcttc cctttctact cacctttgag    12540

tatttcagcc tcttcatgaa tctatctccc tctctttgat ttcatgtaat ctctccttaa    12600

atatttcttt gcatatgtgg gcaagtgtac gtgtgtgtgt gtcatgtgtg gcagaggggc    12660

ttcctaaccc ctgcctgata ggtgcagaac gtcggctatc agagcaagca ttgtggagcg    12720

gttccttatg ccaggctgcc atgtgagatg atccaagacc aaaacaaggc cctagactgc    12780

agtaaaaccc agaactcaag tagggcagaa ggtggaaggc tcatatggat agaaggccca    12840

aagtataaga cagatggttt gagacttgag acccgaggac taagatggaa agcccatgtt    12900

ccaagataga tagaagcctc aggcctgaaa ccaacaaaag cctcaagagc caagaaaaca    12960

gagggtggcc tgaattggac cgaaggcctg agttggatgg aagtctcaag gcttgagtta    13020

gaagtcttaa gacctgggac aggacacatg gaaggcctaa gaactgagac ttgtgacaca    13080

aggccaacga cctaagatta gcccagggtt gtagctggaa gacctacaac ccaaggatgg    13140

aaggcccctg tcacaaagcc tacctagatg gatagaggac ccaagcgaaa aaggtatctc    13200

aagactaacg gccggaatct ggaggcccat gacccagaac ccaggaagga tagaagcttg    13260

aagacctggg gaaatcccaa gatgagaacc ctaaacccta cctcttttct attgtttaca    13320

cttcttactc ttagatattt ccagttctcc tgtttatctt taagcctgat tcttttgaga    13380

tgtacttttt gatgttgccg gttaccttta gattgacagt attatgcctg ggccagtctt    13440

gagccagctt taaatcacag cttttaccta tttgttaggc tatagtgttt tgtaaacttc    13500

tgtttctatt cacatcttct ccacttgaga gagacaccaa aatccagtca gtatctaatc    13560

tggcttttgt taacttccct caggagcaga cattcatata ggtgatactg tatttcagtc    13620

ctttcttttg accccagaag ccctagactg agaagataaa atggtcaggt tgttggggaa    13680

aaaaaagtgc caggctctct agagaaaaat gtgaagagat gctccaggcc aatgagaaga    13740

attagacaag aaatacacag atgtgccaga cttctgagaa gcacctgcca gcaacagctt    13800

ccttctttga gcttaggtga gcaggattct ggggtttggg atttctagtg atggttatgg    13860

aaagggtgac tgtgcctggg acaaagcgag gtcccaaggg gacagcctga actccctgct    13920

catagtagtg gccaaataat ttggtggact gtgccaacgc tactcctggg tttaataccc    13980

atctctaggc ttaaagatga gagaacctgg gactgttgag catgtttaat actttccttg    14040

atttttttct tcctgtttat gtgggaagtt gatttaaatg actgataatg tgtatgaaag    14100

cactgtaaaa cataagagaa aaaccaatta gtgtattggc aatcatgcag ttaacatttg    14160

aaagtgcagt gtaaattgtg aagcattatg taaatcaggg gtccacagtt tttctgtaag    14220

gggtcaaatc ataaatactt tagactgtgg gccatatggt ttctgttaca tatttgtttt    14280

ttaaacaacg tttttataag gtcaaaatca ttcttagttt ttgagccaat tggatttggc    14340

ctgctgttca tagcttacca ccccctgatg tattatttgt tattcagaga aaatttctga    14400

atactactag tttccttttc tgtgcctgtc cctgtgctag gcactaaaaa tgcaatgatt    14460

attgatatct aggtgacctg aaaaaaaata gtgaatgtgc tttgtaaact gtaaagcact    14520

tgtattctac tgtgataagc gttgtggata caaagaaagg agcaagcata aaaaagtgct    14580

ctttcaaaag gatatagtac tatgcagaca caaggaattg tttgataaat gaataaatta    14640

tatgtatatt tgaggccaat ttgtgtttgc tgctctggta attttgagta aaaatgcagt    14700

attccaggta tcagaaacga aaacacatgg aaactgcttt taaactttaa aatatactga    14760

aaacataagg gactaagctt gttgtggtca cctataatgt gccagatacc atgctgggtg    14820

ctagagctac caaaggggga aaagtattct catagaacaa aaaatttcag aaaggtgcat    14880

attaaagtgc tttgtaaact aaagcatgat acaaatgtca atgggctaca tatttatgaa    14940

tgaatgaatg gatgaatgaa tattaagtgc ctcttacata ccagctattt tgggtactgt    15000

aaaatacaag attaattctc ctatgtaata agaggaaagt ttatcctcta tactattcag    15060

atgtaaggaa tgatatattg cttaatttta aacaatcaag actttactgg tgaggttaag    15120

ttaaattatt actgatacat ttttccaggt aaccaggaaa gagctagtat gaggaaatga    15180

agtaatagat gtgagatcca gaccgaaagt cacttaattc agcttgcgaa tgtgctttct    15240

aaattataaa gcacttgtaa atgaaaaatt tgatgctttc tgtatgaata aaactttctg    15300

taagctaggt attgtctcta caaaattctc attgtatagt taaaccacag tgagaagggt    15360

tctataagta gttatacaaa ccaagggttt aaatacctgt taaatagatc aattttgatt    15420

gcctactatg tgaactcact gttaaaggca ctgaaaattt atcatatttc atttagccac    15480

agccaaaaat aaggcaatac ctatgttagc attttgtgaa ctctaaggca ccatataaat    15540

gtaactgttg attttctcac ttggtgctgg gtactaggtt tataaaattg tatgatagtt    15600

attatattgt gcaaataaag taggaaaatt tgaataacaa tgattatctt ttgaatacgc    15660

atacgcaagg gattggttgt ctgaagaatg ccactatagt agttatctat tgtgtgccaa    15720

tctcattgct aggcattggg gatgcaaaga taaaccatct ttattgtgtc ttgggtagca    15780

gaagaaaata tgtgtaaaat caatttataa tttgtaaact gccacccata tataagctat    15840

atctgctgaa tgatcattga ttactcttat ccttagagat aacaactggg ggcacaaaca    15900

tttattatca ttattgaacc tacaacagag atctatgtgt agatttacaa agcctacagt    15960

tctatacaga taggaatgaa ctattggctt actgaatggt gattactttc tgtggggctc    16020

ggaactacat gccctaggat ataaaaatga tgttatcatt atagagtgct cacagaagga    16080

aatgaagtaa tataggtgtg agatccagac caaaagtcat ttaacaagtt tattcagtga    16140

tgaaaacatg ggacaaatgg actaatataa ggcagtgtac taagctgagt agagagataa    16200

agtcctgtcc agaagataca tgcttcctgg cctgattgag gagatggaaa atttttgcaa    16260

aaaacaaggt gttgtggtct tccatccagt ttcttaagtg ctgatgataa aagtgaatta    16320

gacccacctt gacctggcct acagaagtaa aggagtaaaa ataaatgcct caggcgtgct    16380

ttttgattca tttgataaac aaagcatctt ttatgtggaa tataccattc tgggtcctga    16440

ggataagaga gatgagggca ttagatcact gacagctgaa gatagaagaa catctttggt    16500

ttgattgttt aaataatatt tcaatgccta ttctctgcaa ggtactatgt ttcgtaaatt    16560

aaataggtct ggcccagaag acccactcaa ttgcctttga gattaaaaaa aaaaaaaaaa    16620

agaaagaaaa atgcaagttt ctttcaaaat aaagagacat ttttcctagt ttcaggaatc    16680

ccccaaatca cttcctcatt ggcttagttt aaagccagga gactgataaa agggctcagg    16740

gtttgttctt taattcatta actaaacatt ctgcttttat tacagttaaa tggttcaaga    16800

tgtaacaact agttttaaag gtatttgctc attggtctgg cttagagaca ggaagacata    16860

tgagcaataa aaaaaagatt cttttgcatt taccaattta gtaaaaattt attaaaactg    16920

aataaagtgc tgttcttaag tgcttgaaag acgtaaacca aagtgcactt tatctcattt    16980

atcttatggt ggaaacacag gaacaaattc tctaagagac tgtgtttctt tagttgagaa    17040

gaaacttcat tgagtagctg tgatatgttc gatactaagg aaaaactaaa cagatcacct    17100

ttgacatgcg ttgtagagtg ggaataagag agggcttttt attttttcgt tcatacgagt    17160

attgatgaag atgatactaa atgctaaatg aaatatatct gctccaaaag gcatttattc    17220

tgacttggag atgcaacaaa aacacaaaaa tggaatgaag tgatactctt catcaaacag    17280

aagtgactgt tatctcaacc attttgttaa atcctaaaca gaaaacaaaa aaaatcatga    17340

cgaaaagaca cttgcttatt aattggcttg gaaagtagaa tataggagaa aggttactgt    17400

ttattttttt tcatgtattc attcattcta caaatatatt cgggtgccaa taggtacttg    17460

gtataaggtt tttggcccca gagacatggg aaaaaaatgc atgccttccc agagaatgcc    17520

taatactttc cttttggctt gttttcttgt taggggcatg gcttagtccc taaataacat    17580

tgtgtggttt aattcctact ccgtatctct tctaccactc tggccactac gataagcagg    17640

tagctgggtt ttgtagtgag cttgctcctt aagttacagg aactctcctt ataatagaca    17700

cttcattttc ctagtccatc cctcatgaaa aatgactgac cactgctggg cagcaggagg    17760

gatgatgacc aactaattcc caaaccccag tctcattggt accagccttg gggaaccacc    17820

tacacttgag ccacaattgg ttttgaagtg catttacaag gtttgtctat tttcagttct    17880

ttacttttta catgctgaca catacataca ctgcctaaat agatctcttt cagaaacaat    17940

cctcagataa cgcatagcaa aatggagatg gagacatgat ttctcatgca acagcttctc    18000

taattatacc ttagaaatgt tctccttttt atcatcaaat ctgctcaaga agggcttttt    18060

atagtagaat aatatcagtg gatgaaaaca gcttaacatt ttaccatgct taagttttaa    18120

gaataaaata aaaattggaa ataattggcc aaaattgaaa ggaaaaattt ttttaaaatt    18180

tctctaaatg taggcctggc tgggctttga ccttttccgt ttttaaatca ctcacagagg    18240

gtgggacagg aggaagagtg aaggaaaagg tcaaacctgt tttaagggca acctgccttt    18300

gttctgaatt ggtcttaaga acattaccag ctccaggttt aaattgttca gtttcatgca    18360

gttccaatag ctgatcattg ttgagatgag gacaaaatcc tttgtcctca ctagtttgct    18420

ttacattttt gaaaagtatt atttttgtcc aagtgcttat caactaaacc ttgtgttagg    18480

taagaatgga atttattaag tgaatcagtg tgacccttct tgtcataaga ttatcttaaa    18540

gctgaagcca aaatatgctt caaaagaaga ggactttatt gttcattgta gttcatacat    18600

tcaaagcatc tgaactgtag tttctatagc aagccaatta catccataag tggagaagga    18660

aatagataaa tgtcaaagta tgattggtgg agggagcaag gttgaagata atctggggtt    18720

gaaattttct agttttcatt ctgtacattt ttagttagac atcagatttg aaatattaat    18780

gtttaccttt caatgtgtgg tatcagctgg actcagtaac acccctttct tcagctgggg    18840

atggggaatg gattattgga aaatggaaag aagaaagtaa ctaaaagcct tcctttcaca    18900

gtttctggca tcactaccac tactgattaa acaagaataa gagaacattt tatcatcatc    18960

tgctttattc acataaatga agttgtgatg aataaatctg cttttatgca gacacaagga    19020

attaagtggc ttcgtcattg tccttctacc tcaaagataa tttattccaa aagctaagat    19080

aaatggaaga ctcttgaact tgtgaactga tgtgaaatgc agaatctctt ttgagtcttt    19140

gctgtttgga agattgaaaa atattgttca gcatgggtga ccaccagaaa gtaatcttaa    19200

gccatctaga tgtcacaatt gaaacaaact ggggagttgg ttgctattgt aaaataaaat    19260

atactgtttt gaaaactttg aaaaaaaaaa aaaaaa                              19296


<210>  21
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
tgtttttttg tttattgggg ttgtg                                             25


<210>  22
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
taaattttaa attaattaaa ttat                                              24


<210>  23
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
tgttttagaa agaattttaa gtgtagaga                                         29


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
agggagcagt ttgccctact                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
cacatgcagc gtggtatctt                                                   20


<210>  26
<211>  8199
<212>  DNA
<213>  Homo sapiens

<400>  26
ttgccctact agctcctcgg acagctgtaa agaagagtct ctggctcttt agaatactgt       60

aagtactact tcgtagctat taagtaatct ttttcctatt ctattttctt tctcttagat      120

gccacctata gaaaagtcag agggtccagt aagtttcttt ccttcttccc acctcatctg      180

caatatatat atatagagag agaaatagat acatacatac atgcataaat acacatatgt      240

gagttaacca gcagaactgt agaattaata ttgtggaccc agctctatgc taggttacac      300

tgataacctg ggtaggaatg atatcatcct atataatttc attcctgaga tgattttatc      360

gttgaggagc taatgtgagc acatttgaaa taactttaga aaataataag tgctgttttg      420

tgtgaatcat aagtagtagt tttaggaagg gaacccacaa ggatttgaag ttgatagaat      480

aaacttaagg aagtgggttt gctttttctc tttaagccaa gataggatta atattgcagc      540

catctggata gtccagttgg tttattttaa tttcatttgt tttttacctc ttttggagcc      600

atggaaagag atgaaaggga tagagcatag ccattgtgtt tggctatttg cgaaggttgg      660

caaattagtg attgctaaat ctcataagct tgagtatttt aaagttcaga gattgagggc      720

ataaatctaa tacttcggct ccttccacaa ttttactaca tttctgccca agaacagatg      780

accatggata atgcatatcg tagatacttt ttaagtttgg aacctttttg ccaagagggt      840

agtggagaag tgaagtcaaa accttgacct tccttgccta ctttatgctg tagtttatat      900

accttctttc ctcccacctt tcgtaaagct aaaagaagct tagcctcctt aatgttttcc      960

agctgacaaa atattgttta acataacatt cgaaactttt tttctggtgc acattcatgc     1020

atcacagcag gagcaacaag aaccatataa gtgaactggc ttcacttata gcccgtttta     1080

attcatatcc atatttcctc agggcttgtt tccatgcctc ccagccccac tccatatgct     1140

taacaacatt gtctggctga ctgagggtta tatacatcat ggtcttgaac cttcttggaa     1200

acatggtctg tgccattgtt tctcaaaccc aagtaatgct tcatgatgaa acaccttcta     1260

aaggaacaaa attttctgag atcctaaaaa aatgtgtttt gaggaacact gacttaacaa     1320

agatatttga aatgtaaata tgttttccaa tttcacgttg tctttgtcaa agatgtgttt     1380

tatataactt atgtagaact tggggatcca ttagaatata ttcacaaatc cccagggtta     1440

tcaccccaat ttgagaaacc ctggtctatg cttatgaaat cttctattgg taattaaatt     1500

gtcattcatt gtcaacatac aattataatt attattggaa tttgttttaa atgaatgaat     1560

ttggaggtga ttctgtacct taagtcaaga ggaaggatgg cttgatttta ggtggattga     1620

ttatactaga tagcatccaa aggtgaatct tgaagctgta tttaaattca ttgcttgaaa     1680

taatttccac ccttaagaaa aatctctagc aattgtaaaa agggatgctc tggaaatgtg     1740

ggcatcttca aaatagagat aattcttgtg ttagttcaac aaatattatt gtaccaggtg     1800

ctggaataaa tagcaaaacc aaagacagga tttatatcaa ggaatttgct ttcttatgga     1860

ggatgcagaa ggaaatcatt atggttttgg gcagaaatgc ttagacttta gtcctggctc     1920

tgagtttggt tcagatcacc atcaatctga ccatctcgag actgctagtg aaataagata     1980

ggggcttata tcaaatacct aaatccctga aaatgacatt ttgtgatttg gaaaattttc     2040

aaaagtctaa tgaaggaaac ttttttggca tttctttaaa tgattattgt catttctttt     2100

ctgacttttc cctttataaa accttaacat gtaggattgg aggaagtttt ctgaccattt     2160

tctcatatcc tctttcagct ttatctttct gtaacttcca tttctctagc cacctcccta     2220

aattacagaa gactgtgaga cccagggctg ctgtgattag gcattcataa tttcttttca     2280

gggtgtttgt gccctgatta tcaaatgtac agcttgaagg gagttcatgt cttaaagtaa     2340

tgaattaaga gttgaccttt gttgactgct aaaatattct tatatgtgaa agcatcctgg     2400

aaaaatacgt taccagctta aagagaaaga aactaatgat tatatctgaa ctgagctaat     2460

gcctcttctc ttcccccaaa ccttatcagt ttggatggca aagagtaatg atgtgtcagt     2520

taaacagagc taatgccttc ctctgccttg tcttaaagac tggattggga gaaaattgat     2580

attctcacta ccatattttg ggctgtaggc aagtagcatt ttacacaggt ttccttcaaa     2640

aatccaactc aagttggagc tcatgtattt aagacatagc tggcctgctg aatttaacaa     2700

gttaaacttc agtggccatg tacagttata tatcactata tatatgtgta ttaggctgtc     2760

gagttggtca tgtttttgtt ggtgacttag gctttacttg atagctcttc cttgaccttt     2820

ccaaattgag tactgataca tggagcttgg gcttcttctg catcttatac aaatgagttt     2880

ggtaaagaag cctctccttt actgttttga tgtttatatt agaaataact tttgattatt     2940

ttttttcatg ttaggatgag aaactgaaac aaaatgtaaa tttgaccggt gctagacttc     3000

ttaaattatg ggtagactta aagtattatt ttccttaacc aattagaatg ctagtcttct     3060

agtgttcccg gaaacatgag aggttatgca gtagacccaa gcaataccct cttattacat     3120

aatcaagtgc gtataagaat ttaaaaatag ggatatgact ggaacatcac tgtactttac     3180

caggtcccat tataaaatta tctatgttac tttacccata gctttgaaaa ctagtggcat     3240

agtatatttt atagtatgct gttagtgtga ttggcattga acagtgatgg gatataatca     3300

ctctacaatc tatatgttat taaagttttc cagccttata gatctccctt gactgaaaat     3360

tagctactaa cttacgactt attttttaca gcagattgac taggtctttc caggaaatct     3420

gttgatgtac aaaaacaaag tttaattgct aatgtttttt taaaaaataa ctttttgata     3480

ttacggatac ctggttattt gggccttgta tattttaaca tcaaaattac ctattataaa     3540

tccatataaa cagaaaagaa agagagtaag tctttagatc agatctgcaa acaatgatgg     3600

tacgtactgt agaaaaatct ggaacataga cttaccagtt cttaggttcc attttgcttg     3660

ctttttaaaa actgtgtctt ataagtcttc agcaactggt tgggagattt ttagaaaaaa     3720

taacctttta atgttagaac agtgtagaga tttacagaat gattctgaag atagagtttc     3780

tgtgtacttc acacccagtt tttcccagtg ttaacatttt acattagttt ggtacatttg     3840

tcacaacaaa ccaatattga tacattatta ttaactagag tccatatttt attcagattt     3900

ccttagtttt tccttaatgt tctttttgtg ttccaggatc ccattgaaga taccacgctg     3960

catgtgtcct tagtagtcat gtctccttag gctcctcttg gtaatgacag tttctcagac     4020

tctttgtttt tgatgaactt cacagttttg aggactaatg gtccagtatt ctatagaatg     4080

tctctctatt ggaatttgtc tgatgttctt ctcatgacta gattgggttt atgagtgttt     4140

aggaggaaga ccacaaaggt agagtgccat tcttatcact tatcaagagt acatactatc     4200

aacatgactt atcactgttt atgttatcct taatcacctg tctgaggtac tatttgtcag     4260

gtttctccag cgtaaaatta gtctttattt ctccatttcc ctactatact gttcacatag     4320

gaagtcacta tgtgcagcca gcacttaagg aatgggaaat taccttccac ctcattgagg     4380

gcagagtatt tacataaatt atttggaatt cttttgcaca ggatgtcttt tctccacaat     4440

gtattgtgtt tattcagtca tttatatcag tatgatctca gggatatttt atactctggg     4500

ttataataca gtattacttt attctgttgt tcaaattgtt ccagctttgg ccattgggag     4560

gtctttcatt tggctttgat ataaccccat gaatgtgggt tttttgtttg agcactttct     4620

tatttttgga actacaacat gcttcagact catttgcata tctcctgcct ggacctaaaa     4680

tgatgtattt ctgcaaggag ccttgatact ttttattgga gagtaatatt agaaatcaag     4740

aagtgaatgc taggtgcgct cattactact ggagtgtcat tccttcaaga ccttttcagt     4800

tgacaagagc aaggagatat atatttgcat tctaacgtgt gtatatgcac atagctataa     4860

atatatataa ccatctgtat ctatattaaa ctaaatgtgt ttatacctac gtctccaact     4920

ctaatcattg ccacatggat cattatagtc tcacctcctt gcttatctgt tacctcccat     4980

ttctacagtg agaaacctgg cttggttggg aaatttttct gttaatatta cggtagtgag     5040

tgtttgacat ttgcttctat ggttaagttt agggagagtt tagctgtagg gtattcttga     5100

aactagaaat gacccttctg ccctaaatgt ttctgccagt tttgaaacgt aaaataggtt     5160

gcagaaacaa actttatctt aagaaccaga atttacttca atccacattt tgacattgat     5220

tttcagatta aattattctg atatcgccag gtaagctgtt ccttgggtat gcatttcttc     5280

tttccgtttt tttctaagag ctaaaggacc ctgagaacac tggaggtggg aaaggaaggg     5340

aaaggcatgt tcacacgtgg gataggaaag gttcatttac tgacctccag ctagccttcc     5400

aaagtgccta tttaagaccc aaggagtaga tgtcttcctt ggcaattgta acccaaatat     5460

aatttttaac ctttcaattt tagtcaagaa agttggtgtg ctgttacaaa aagtgccctg     5520

attaacagca ttgtcatgtg cattgcatat taatcagcaa tttaaaataa catgaaatta     5580

tgttgagtat aattttaata ttttatatta gatattagtt tgagacagtg tttctcaagt     5640

ctgtataata agtttgatag tagggaggtt ttctctcaag aaaagaatta ttcagtgtgc     5700

acctacataa tcactgctta gattctacaa ttaatatttt gctatatttg attaaacgtt     5760

ttctgtaaaa gaaaaatatt attatgtact atttaggttt atgggaataa ttgttaagtt     5820

aaagtgtatg aacaaacctg gaatgaaatc tgtttgccta catctataat acaactataa     5880

aacatagcag atgtacaaat tagtagttaa tagataacta aaatgcaaat atggcactac     5940

tattatagta ttatagtttc ttttgagtgg cgtgtctgta atatcacatg ctgtgttgat     6000

gcacttcacc aaactgctgt tttcaaactg ctttaaatcc tgccattata gcacatagca     6060

atgctatttc actttcattt ggcacaaaac acatttatat attgtttgct tctcttcttt     6120

tctgtaatcc ccaggcaaca aaactagaac atttgccact aatctggcaa cgtggtccta     6180

tattatgaag tagtcatata gctgatctaa actatcctta cagtgaaatg agagtattgt     6240

gaaagttttg tagaaagctc cccatatgtc ctgagaatct atgcacagac cccacagtta     6300

aaagaccttt gaattgtggg aagacatggg tttaagtatc acttggttac cttctatttg     6360

tgtaacattg aggtagtttc atcttctggg ttcccagttt ccttagagaa tgaaaatgtt     6420

gaattatgtg attttttttt ttttttgaga cggagttttg ctctttcgcc caggctggag     6480

tgaagtagca cgatctcgac tcactgcaac ctccttcccc catgatcaag caattctcct     6540

gcctcagcct cccaagtagc tgggattaca ggcacccgcc ccccaccccc cgcccccagc     6600

taatgtttgt atttttagta cagatggagt tttgccgtgt tggccaggct ggtctcgaac     6660

ttctgacctc aggtgatcca ctcgccttgg cctcccaaag tgctaggatt acaggcatga     6720

gccactgcgc ctggcctatg tgattattaa tatcacgtct agctgtgaca attctgtctg     6780

atgctggagt atttgaacca gatggctggc tgtgccactc agttattctc tccataagac     6840

tttgatattt tgttggtctg caagatgacg gattctcaaa attcttgtca gtgaatattg     6900

aaccctagtg aaatgtatgg ttctgtatca gttccaaaat gtaaccactt tctctagcct     6960

tagattccca gttccaaaat gtaaccattt tctctagcct tagattcccg ttaagggaaa     7020

gggaatgctc tttgagtatg tcatcaccat agtaacaggc aaaactagag ggctttgatg     7080

ctaaagcaag atactccata aatatgctta agaagacttg gggagactgg aatagttgtt     7140

cccttttaga tgccagtgta taaatgaatt tgagctagga tccgtttatt taaaatttct     7200

ttaggtgtat ttgcttgcat atggagtgca catttactct cattaatgga gttttaggaa     7260

gcagtagagt aaatgcataa acatgtatga accgccatgt ttaactggaa gcctgcattt     7320

ggaagtcaag tatctaatct tagattaaat taggatgggg aaggatgttg gcaagagatt     7380

ttgaagcttg ttctgcttat attgagaaca tcatagaaca gtttggcctt tttaaagcta     7440

gagaatagtg ttgaataagt gatgttccat atattcctgt ttgacattga cataaaggtt     7500

tcctcatgat acagtaatcc ctgatcaggg atctggaagc ctgtattcat ttaaggtact     7560

caggtttaac atactgggtg cttttcacac catactatac agtaccatgc aaagtgcttt     7620

caagactgca aatttggctt agatcccctt tagtgagctc ctatgctata gtaaaggtag     7680

atagccaatt attaaaaaca gtcaagacaa ttgcacctct aagcagtagt agcagttgcc     7740

acaccacctt gaatcttgaa gtattttcag caacaggatg accattagcc acaaatttag     7800

tgtcagccct taaggtcggt attggtttga cccatatttt catgtagttc tttttcttca     7860

cttgtctaat cttcccgtgt actgccaggg cttgtcatta gaggacttta gggagaccaa     7920

gcaggctaga aagtagagac aggagatacc tatgtctaat gcttcagttt atacttccta     7980

ggtttttttc attggggttt ttgtaactct tttggtatcc taccggtgct ttggtagcct     8040

actgaaccct gtctttcttc ttaaggacat tctgagcatg tgagacctga ggactgcaaa     8100

cagctataag aggctccaaa ttaatcatat ctttcccttt gagaatctgg ccaagctcca     8160

gctaatctac ttggatgggt tgccagctat ctggagaaa                            8199


<210>  27
<211>  3578
<212>  DNA
<213>  Homo sapiens

<400>  27
aatttcacct tttttctgag tctggcctcc tttctgctgt ttctactttt tatctcacat       60

ttctcatttc tgcatttcct ttctgcctct cttgggctat tctctctctc ctcccctgcg      120

tgcctcagca tctcttgctg tttgtgattt tctatttcag tattaatctc tgttggcttg      180

tatttgttct ctgcttcttc cctttctact cacctttgag tatttcagcc tcttcatgaa      240

tctatctccc tctctttgat ttcatgtaat ctctccttaa atatttcttt gcatatgtgg      300

gcaagtgtac gtgtgtgtgt gtcatgtgtg gcagaggggc ttcctaaccc ctgcctgata      360

ggtgcagaac gtcggctatc agagcaagca ttgtggagcg gttccttatg ccaggctgcc      420

atgtgagatg atccaagacc aaaacaaggc cctagactgc agtaaaaccc agaactcaag      480

tagggcagaa ggtggaaggc tcatatggat agaaggccca aagtataaga cagatggttt      540

gagacttgag acccgaggac taagatggaa agcccatgtt ccaagataga tagaagcctc      600

aggcctgaaa ccaacaaaag cctcaagagc caagaaaaca gagggtggcc tgaattggac      660

cgaaggcctg agttggatgg aagtctcaag gcttgagtta gaagtcttaa gacctgggac      720

aggacacatg gaaggcctaa gaactgagac ttgtgacaca aggccaacga cctaagatta      780

gcccagggtt gtagctggaa gacctacaac ccaaggatgg aaggcccctg tcacaaagcc      840

tacctagatg gatagaggac ccaagcgaaa aaggtatctc aagactaacg gccggaatct      900

ggaggcccat gacccagaac ccaggaagga tagaagcttg aagacctggg gaaatcccaa      960

gatgagaacc ctaaacccta cctcttttct attgtttaca cttcttactc ttagatattt     1020

ccagttctcc tgtttatctt taagcctgat tcttttgaga tgtacttttt gatgttgccg     1080

gttaccttta gattgacagt attatgcctg ggccagtctt gagccagctt taaatcacag     1140

cttttaccta tttgttaggc tatagtgttt tgtaaacttc tgtttctatt cacatcttct     1200

ccacttgaga gagacaccaa aatccagtca gtatctaatc tggcttttgt taacttccct     1260

caggagcaga cattcatata ggtgatactg tatttcagtc ctttcttttg accccagaag     1320

ccctagactg agaagataaa atggtcaggt tgttggggaa aaaaaagtgc caggctctct     1380

agagaaaaat gtgaagagat gctccaggcc aatgagaaga attagacaag aaatacacag     1440

atgtgccaga cttctgagaa gcacctgcca gcaacagctt ccttctttga gcttaggtga     1500

gcaggattct ggggtttggg atttctagtg atggttatgg aaagggtgac tgtgcctggg     1560

acaaagcgag gtcccaaggg gacagcctga actccctgct catagtagtg gccaaataat     1620

ttggtggact gtgccaacgc tactcctggg tttaataccc atctctaggc ttaaagatga     1680

gagaacctgg gactgttgag catgtgtaat actttccttg atttttttct tcctgtttat     1740

gtgggaagtt gatttaaatg actgataatg tgtatgaaag cactgtaaaa cataagagaa     1800

aaaccaatta gtgtattggc aatcatgcag ttaacatttg aaagtgcagt gtaaattgtg     1860

aagcattatg taaatcaggg gtccacagtt tttctgtaag gggtcaaatc ataaatactt     1920

tagactgtgg gccatatggt ttctgttaca tatttgtttt ttaaacaacg tttttataag     1980

gtcaaaatca ttcttagttt ttgagccaat tggatttggc ctgctgttca tagcttacca     2040

ccccctgatg tattatttgt tattcagaga aaatttctga atactactag tttccttttc     2100

tgtgcctgtc cctgtgctag gcactaaaaa tgcaatgatt attgatatct aggtgacctg     2160

aaaaaaaata gtgaatgtgc tttgtaaact gtaaagcact tgtattctac tgtgataagc     2220

gttgtggata caaagaaagg agcaagcata aaaaagtgct ctttcaaaag gatatagtac     2280

tatgcagaca caaggaattg tttgataaat gaataaatta tatgtatatt tgaggccaat     2340

ttgtgtttgc tgctctggta attttgagta aaaatgcagt attccaggta tcagaaacga     2400

aaacacatgg aaactgcttt taaactttaa aatatactga aaacataagg gactaagctt     2460

gttgtggtca cctataatgt gccagatacc atgctgggtg ctagagctac caaaggggga     2520

aaagtattct catagaacaa aaaatttcag aaaggtgcat attaaagtgc tttgtaaact     2580

aaagcatgat acaaatgtca atgggctaca tatttatgaa tgaatgaatg gatgaatgaa     2640

tattaagtgc ctcttacata ccagctattt tgggtactgt aaaatacaag attaattctc     2700

ctatgtaata agaggaaagt ttatcctcta tactattcag atgtaaggaa tgatatattg     2760

cttaatttta aacaatcaag actttactgg tgaggttaag ttaaattatt actgatacat     2820

ttttccaggt aaccaggaaa gagctagtat gaggaaatga agtaatagat gtgagatcca     2880

gaccgaaagt cacttaattc agcttgcgaa tgtgctttct aaattataaa gcacttgtaa     2940

atgaaaaatt tgatgctttc tgtatgaata aaactttctg taagctaggt attgtctcta     3000

caaaattctc attgtatagt taaaccacag tgagaagggt tctataagta gttatacaaa     3060

ccaagggttt aaatacctgt taaatagatc aattttgatt gcctactatg tgaactcact     3120

gttaaaggca ctgaaaattt atcatatttc atttagccac agccaaaaat aaggcaatac     3180

ctatgttagc attttgtgaa ctctaaggca ccatataaat gtaactgttg attttctcac     3240

ttggtgctgg gtactaggtt tataaaattg tatgatagtt attatattgt gcaaataaag     3300

taggaaaatt tgaataacaa tgattatctt ttgaatacgc atacgcaagg gattggttgt     3360

ctgaagaatg ccactatagt agttatctat tgtgtgccaa tctcattgct aggcattggg     3420

gatgcaaaga taaaccatct ttattgtgtc ttgggtagca gaagaaaata tgtgtaaaat     3480

caatttataa tttgtaaact gccacccata tataagctat atctgctgaa tgatcattga     3540

ttactcttat ccttagagat aacaactggg ggcacaaa                             3578


<210>  28
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  29
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  30
<211>  3808
<212>  DNA
<213>  Homo sapiens

<400>  30
cttcctggac tggggatccc ggctaaatat agctgtttct gtcttacaac acaggctcca       60

gtatataaat caggcaaatt ccccatttga gcatgaacct ctgaaaactg ccggcatctg      120

aggtttcctc caaggccctc tgaagtgcag cccataatga aggtcttggc ggcagtacac      180

agcccagggg gagccgttcc ccaacaacct ggacaagcta tgtggcccca acgtgacgga      240

cttcccgccc ttccacgcca acggcacgga gaaggccaag ctggtggagc tgtaccgcat      300

agtcgtgtac cttggcacct ccctgggcaa catcacccgg gaccagaaga tcctcaaccc      360

cagtgccctc agcctccaca gcaagctcaa cgccaccgcc gacatcctgc gaggcctcct      420

tagcaacgtg ctgtgccgcc tgtgcagcaa gtaccacgtg ggccatgtgg acgtgaccta      480

cggccctgac acctcgggta aggatgtctt ccagaagaag aagctgggct gtcaactcct      540

ggggaagtat aagcagatca tcgccgtgtt ggcccaggcc ttctagcagg aggtcttgaa      600

gtgtgctgtg aaccgaggga tctcaggagt tgggtccaga tgtgggggcc tgtccaaggg      660

tggctggggc ccagggcatc gctaaaccca aatgggggct gctggcagac cccgagggtg      720

cctggccagt ccactccact ctgggctggg ctgtgatgaa gctgagcaga gtggaaactt      780

ccatagggag ggagctagaa gaaggtgccc cttcctctgg gagattgtgg actggggagc      840

gtgggctgga cttctgcctc tacttgtccc tttggcccct tgctcacttt gtgcagtgaa      900

caaactacac aagtcatcta caagagccct gaccacaggg tgagacagca gggcccaggg      960

gagtggacca gcccccagca aattatcacc atctgtgcct ttgctgcccc ttaggttggg     1020

acttaggtgg gccagagggg ctaggatccc aaaggactcc ttgtccccta gaagtttgat     1080

gagtggaaga tagagagggg cctctgggat ggaaggctgt cttcttttga ggatgatcag     1140

agaacttggg cataggaaca atctggcaga agtttccaga aggaggtcac ttggcattca     1200

ggctcttggg gaggcagaga agccaccttc aggcctggga aggaagacac tgggaggagg     1260

agaggcctgg aaagctttgg taggttcttc gttctcttcc ccgtgatctt ccctgcagcc     1320

tgggatggcc agggtctgat ggctggacct gcagcagggg tttgtggagg tgggtagggc     1380

aggggcaggt tgctaagtca ggtgcagagg ttctgaggga cccaggctct tcctctgggt     1440

aaaggtctgt aagaaggggc tggggtagct cagagtagca gctcacatct gaggccctgg     1500

gaggccttgt gaggtcacac agaggtactt gagggggact ggaggccgtc tctggtcccc     1560

agggcaaggg aacagcagaa cttagggtca gggtctcagg gaaccctgag ctccaagcgt     1620

gctgtgcgtc tgacctggca tgatttctat ttattatgat atcctattta tattaactta     1680

ttggtgcttt cagtggccaa gttaattccc ctttccctgg tccctactca acaaaatatg     1740

atgatggctc ccgacacaag cgccagggcc agggcttagc agggcctggt ctggaagtcg     1800

acaatgttac aagtggaata agccttacgg gtgaagctca gagaagggtc ggatctgaga     1860

gaatggggag gcctgagtgg gagtgggggg ccttgctcca ccccccccca tcccctactg     1920

tgacttgctt tagggtgtca gggtccaggc tgcaggggct gggccaattt gtggagaggc     1980

cgggtgcctt tctgtcttga ttccaggggg ctggttcaca ctgttcttgg gcgccccagc     2040

attgtgttgt gaggcgcact gttcctggca gatattgtgc cccctggagc agtgggcaag     2100

acagtccttg tggcccaccc tgtccttgtt tctgtgtccc catgctgcct ctgaaatagc     2160

gccctggaac aaccctgccc ctgcacccag catgctccga cacagcaggg aagctcctcc     2220

tgtggcccgg acacccatag acggtgcggg gggcctggct gggccagacc ccaggaaggt     2280

ggggtagact ggggggatca gctgcccatt gctcccaaga ggaggagagg gaggctgcag     2340

atgcctggga ctcagaccag gaagctgtgg gccctcctgc tccaccccca tcccactccc     2400

acccatgtct gggctcccag gcagggaacc cgatctcttc ctttgtgctg gggccaggcg     2460

agtggagaaa cgccctccag tctgagagca ggggagggaa ggaggcagca gagttggggc     2520

agctgctcag agcagtgttc tggcttcttc tcaaaccctg agcgggctgc cggcctccaa     2580

gttcctccga caagatgatg gtactaatta tggtactttt cactcacttt gcacctttcc     2640

ctgtcgctct ctaagcactt tacctggatg gcgcgtgggc agtgtgcagg caggtcctga     2700

ggcctggggt tggggtggag ggtgcggccc ggagttgtcc atctgtccat cccaacagca     2760

agacgaggat gtggctgttg agatgtgggc cacactcacc cttgtccagg atgcagggac     2820

tgccttctcc ttcctgcttc atccggctta gcttggggct ggctgcattc ccccaggatg     2880

ggcttcgaga aagacaaact tgtctggaaa ccagagttgc tgattccacc cggggggccc     2940

ggctgactcg cccatcacct catctccctg tggacttggg agctctgtgc caggcccacc     3000

ttgcggccct ggctctgagt cgctctccca cccagcctgg acttggcccc atgggaccca     3060

tcctcagtgc tccctccaga tcccgtccgg cagcttggcg tccaccctgc acagcatcac     3120

tgaatcacag agcctttgcg tgaaacagct ctgccaggcc gggagctggg tttctcttcc     3180

ctttttatct gctggtgtgg accacacctg ggcctggccg gaggaagaga gagtttacca     3240

agagagatgt ctccgggccc ttatttatta tttaaacatt tttttaaaaa gcactgctag     3300

tttacttgtc tctcctcccc atcgtcccca tcgtcctcct tgtccctgac ttggggcact     3360

tccaccctga cccagccagt ccagctctgc cttgccggct ctccagagta gacatagtgt     3420

gtggggttgg agctctggca cccggggagg tagcatttcc ctgcagatgg tacagatgtt     3480

cctgccttag agtcatctct agttccccac ctcaatcccg gcatccagcc ttcagtcccg     3540

cccacgtgct agctccgtgg gcccaccgtg cggccttaga ggtttccctc cttcctttcc     3600

actgaaaagc acatggcctt gggtgacaaa ttcctctttg atgaatgtac cctgtgggga     3660

tgtttcatac tgacagatta tttttattta ttcaatgtca tatttaaaat atttattttt     3720

tataccaaat gaatactttt ttttttaaga aaaaaaagag aaatgaataa agaatctact     3780

cttggctggc aaaaaaaaaa aaaaaaaa                                        3808


<210>  31
<211>  2217
<212>  DNA
<213>  Homo sapiens

<400>  31
ccccgccgcc gccgcccttc gcgccctggg ccatctccct cccacctccc tccgcggagc       60

agccagacag cgagggcccc ggccgggggc aggggggacg ccccgtccgg ggcacccccc      120

cggctctgag ccgcccgcgg ggccggcctc ggcccggagc ggaggaagga gtcgccgagg      180

agcagcctga ggccccagag tctgagacga gccgccgccg cccccgccac tgcggggagg      240

agggggagga ggagcgggag gagggacgag ctggtcggga gaagaggaaa aaaacttttg      300

agacttttcc gttgccgctg ggagccggag gcgcggggac ctcttggcgc gacgctgccc      360

cgcgaggagg caggacttgg ggaccccaga ccgcctccct ttgccgccgg ggacgcttgc      420

tccctccctg ccccctacac ggcgtccctc aggcgccccc attccggacc agccctcggg      480

agtcgccgac ccggcctccc gcaaagactt ttccccagac ctcgggcgca ccccctgcac      540

gccgccttca tccccggcct gtctcctgag cccccgcgca tcctagaccc tttctcctcc      600

aggagacgga tctctctccg acctgccaca gatcccctat tcaagaccac ccaccttctg      660

gtaccagatc gcgcccatct aggttatttc cgtgggatac tgagacaccc ccggtccaag      720

cctcccctcc accactgcgc ccttctccct gaggacctca gctttccctc gaggccctcc      780

taccttttgc cgggagaccc ccagcccctg caggggcggg gcctccccac cacaccagcc      840

ctgttcgcgc tctcggcagt gccggggggc gccgcctccc ccatgccgcc ctccgggctg      900

cggctgctgc cgctgctgct accgctgctg tggctactgg tgctgacgcc tggccggccg      960

gccgcgggac tatccacctg caagactatc gacatggagc tggtgaagcg gaagcgcatc     1020

gaggccatcc gcggccagat cctgtccaag ctgcggctcg ccagcccccc gagccagggg     1080

gaggtgccgc ccggcccgct gcccgaggcc gtgctcgccc tgtacaacag cacccgcgac     1140

cgggtggccg gggagagtgc agaaccggag cccgagcctg aggccgacta ctacgccaag     1200

gaggtcaccc gcgtgctaat ggtggaaacc cacaacgaaa tctatgacaa gttcaagcag     1260

agtacacaca gcatatatat gttcttcaac acatcagagc tccgagaagc ggtacctgaa     1320

cccgtgttgc tctcccgggc agagctgcgt ctgctgaggc tcaagttaaa agtggagcag     1380

cacgtggagc tgtaccagaa atacagcaac aattcctggc gatacctcag caaccggctg     1440

ctggcaccca gcgactcgcc agagtggtta tcttttgatg tcaccggagt tgtgcggcag     1500

tggttgagcc gtggagggga aattgagggc tttcgcctta gcgcccactg ctcctgtgac     1560

agcagggata acacactgca agtggacatc aacgggttca ctaccggccg ccgaggtgac     1620

ctggccacca ttcatggcat gaaccggcct ttcctgcttc tcatggccac cccgctggag     1680

agggcccagc atctgcaaag ctcccggcac cgccgagccc tggacaccaa ctattgcttc     1740

agctccacgg agaagaactg ctgcgtgcgg cagctgtaca ttgacttccg caaggacctc     1800

ggctggaagt ggatccacga gcccaagggc taccatgcca acttctgcct cgggccctgc     1860

ccctacattt ggagcctgga cacgcagtac agcaaggtcc tggccctgta caaccagcat     1920

aacccgggcg cctcggcggc gccgtgctgc gtgccgcagg cgctggagcc gctgcccatc     1980

gtgtactacg tgggccgcaa gcccaaggtg gagcagctgt ccaacatgat cgtgcgctcc     2040

tgcaagtgca gctgaggtcc cgccccgccc cgccccgccc cggcaggccc ggccccaccc     2100

cgccccgccc ccgctgcctt gcccatgggg gctgtattta aggacacccg tgccccaagc     2160

ccacctgggg ccccattaaa gatggagaga ggactgcgga aaaaaaaaaa aaaaaaa        2217


<210>  32
<211>  6774
<212>  DNA
<213>  Homo sapiens

<400>  32
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc       60

gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg      120

ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt      180

gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc      240

gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga      300

ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc      360

ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc      420

gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga      480

gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc      540

acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc      600

ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc      660

aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta      720

tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg      780

aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg      840

tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag      900

ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat      960

ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat     1020

gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta     1080

accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata     1140

ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc     1200

tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa     1260

tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct     1320

tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt     1380

tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt     1440

aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat     1500

acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt     1560

cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg     1620

aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg     1680

tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa     1740

aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat     1800

tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct     1860

caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca     1920

agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata     1980

tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt     2040

aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt     2100

tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc     2160

ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa     2220

ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa     2280

tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat     2340

ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca     2400

aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt     2460

cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt     2520

ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa     2580

gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta     2640

ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg     2700

gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcgtct gccatttttc     2760

aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa     2820

caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct     2880

gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg     2940

tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt     3000

ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa     3060

ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt     3120

gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat     3180

acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata     3240

tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg     3300

aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat     3360

ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta     3420

tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc     3480

tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc     3540

agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta     3600

acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt     3660

atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat     3720

tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata     3780

ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac     3840

taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt     3900

ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat     3960

atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg     4020

ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc     4080

tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt     4140

aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt     4200

tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa     4260

acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac     4320

aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt     4380

tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat     4440

ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag     4500

ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta     4560

gctgctttca gggttttatg aattttcagg caaagcttta atttatacta agcttaggaa     4620

gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat     4680

gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa     4740

aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc     4800

ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag     4860

tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa     4920

aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata     4980

gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc     5040

accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc     5100

acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg     5160

tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg     5220

atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt     5280

ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag     5340

aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa     5400

ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg     5460

aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc     5520

tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg     5580

agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt     5640

actatgtttt gacttcctga ctattaaaaa taaatagtag atacaatttt cataaagtga     5700

agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta     5760

aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat     5820

tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat     5880

atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag     5940

gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta     6000

tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa     6060

attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc     6120

ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct     6180

ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata     6240

aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat     6300

tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc     6360

atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc     6420

caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat     6480

gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct     6540

agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat     6600

aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca     6660

gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt     6720

gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tccc           6774


<210>  33
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 
            340                 345                 350         


Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 
        355                 360                 365             


Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
    370                 375                 


<210>  34
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Val Gly Gln Ser Pro Ala Ala Val Gly Leu Gly Ala Gly 
            340                 345                 350         


Glu Gln Gly Gly Thr 
        355         


<210>  35
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Ala Leu Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn 
            260                 265                 270         


Lys Arg Ile Thr Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln 
        275                 280                 285             


Tyr Tyr Asp Pro Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe 
    290                 295                 300                 


Ala Met Glu Leu Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile 
305                 310                 315                 320 


Phe Gln Glu Thr Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
                325                 330                 335 


<210>  36
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  36

Pro Arg Arg Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu 
1               5                   10                  15      


Met Val Lys Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu 
            20                  25                  30          


Gln Tyr Ile Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp 
        35                  40                  45              


His Val Arg Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu 
    50                  55                  60                  


His Gln Thr Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu 
65                  70                  75                  80  


Arg Phe Arg His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala 
                85                  90                  95      


Ser Thr Leu Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met 
            100                 105                 110         


Glu Thr Asp Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp 
        115                 120                 125             


His Ile Cys Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile 
    130                 135                 140                 


His Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu 
145                 150                 155                 160 


Ile Asn Thr Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg 
                165                 170                 175     


Ile Ala Asp Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val 
            180                 185                 190         


Ala Thr Arg Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly 
        195                 200                 205             


Tyr Thr Lys Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu 
    210                 215                 220                 


Met Leu Ser Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln 
225                 230                 235                 240 


Leu Asn His Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu 
                245                 250                 255     


Asn Cys Ile Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro 
            260                 265                 270         


Ser Lys Thr Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser 
        275                 280                 285             


Lys Ala Leu Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys 
    290                 295                 300                 


Arg Ile Thr Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr 
305                 310                 315                 320 


Tyr Asp Pro Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala 
                325                 330                 335     


Met Glu Leu Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe 
            340                 345                 350         


Gln Glu Thr Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
        355                 360                 365     


<210>  37
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  38
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  39
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asn Gln Leu Gln Gln Ile Met Arg Leu Thr Gly 
225                 230                 235                 240 


Thr Pro Pro Ala Tyr Leu Ile Asn Arg Met Pro Ser His Glu Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  40
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  41
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Gly Lys Leu Thr Ile Tyr Pro His 
        275                 280                 285             


Leu Met Asp Ile Glu Leu Val Met Ile 
    290                 295         


<210>  42
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Leu Ser 
                245                 250                 255     


Thr Cys Trp Arg Arg Cys Leu Tyr Trp Thr Gln Ile Arg Glu Leu Gln 
            260                 265                 270         


Arg Pro Lys Pro Leu His Met Pro Thr Leu Leu Ser Thr Thr Ile Leu 
        275                 280                 285             


Met Met Asn Gln Trp Pro Ile Leu Met Ile Ser Pro Leu Lys Ala Gly 
    290                 295                 300                 


Thr Ser Leu 
305         


<210>  43
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Gly Pro Arg Ala Gly Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Val Trp Glu Val Pro Gln Arg Leu Gln Gly Leu Arg Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ser Ala Tyr Asp Ala Arg Leu Arg Gln 
        35                  40                  45              


Lys Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Leu Ile His 
    50                  55                  60                  


Ala Arg Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Leu Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Thr Ser Ile 
                85                  90                  95      


Glu Asp Phe Ser Glu Val Tyr Leu Val Thr Thr Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Ala Leu Ser Asp Glu His Val Gln 
        115                 120                 125             


Phe Leu Val Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Val Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Arg Ile Leu Asp Phe Gly Leu Ala Arg Gln Ala Asp 
                165                 170                 175     


Glu Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Gln Gly Lys Ala Leu Phe Pro 
    210                 215                 220                 


Gly Ser Asp Tyr Ile Asp Gln Leu Lys Arg Ile Met Glu Val Val Gly 
225                 230                 235                 240 


Thr Pro Ser Pro Glu Val Leu Ala Lys Ile Ser Ser Glu His Ala Arg 
                245                 250                 255     


Thr Tyr Ile Gln Ser Leu Pro Pro Met Pro Gln Lys Asp Leu Ser Ser 
            260                 265                 270         


Ile Phe Arg Gly Ala Asn Pro Leu Ala Ile Asp Leu Leu Gly Arg Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Gln Arg Val Ser Ala Ala Glu Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ser Gln Tyr His Asp Pro Glu Asp Glu Pro Glu Ala 
305                 310                 315                 320 


Glu Pro Tyr Asp Glu Ser Val Glu Ala Lys Glu Arg Thr Leu Glu Glu 
                325                 330                 335     


Trp Lys Glu Leu Thr Tyr Gln Glu Val Leu Ser Phe Lys Pro Pro Glu 
            340                 345                 350         


Pro Pro Lys Pro Pro Gly Ser Leu Glu Ile Glu Gln 
        355                 360                 


<210>  44
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 
1               5                   10                  15      


Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 
            20                  25                  30          


Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 
        35                  40                  45              


Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 
    50                  55                  60                  


Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 
65                  70                  75                  80  


Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 
                85                  90                  95      


Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met 
            100                 105                 110         


Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 
        115                 120                 125             


Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile 
    130                 135                 140                 


His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala 
145                 150                 155                 160 


Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
                165                 170                 175     


Gln Ala Asp Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp 
        195                 200                 205             


Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr 
    210                 215                 220                 


Leu Phe Lys Gly Ser Asp His Leu Asp Gln Leu Lys Glu Ile Met Lys 
225                 230                 235                 240 


Val Thr Gly Thr Pro Pro Ala Glu Phe Val Gln Arg Leu Gln Ser Asp 
                245                 250                 255     


Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro Glu Leu Glu Lys Lys Asp 
            260                 265                 270         


Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro Leu Ala Val Asn Leu Leu 
        275                 280                 285             


Glu Lys Met Leu Val Leu Asp Ala Glu Gln Arg Val Thr Ala Gly Glu 
    290                 295                 300                 


Ala Leu Ala His Pro Tyr Phe Glu Ser Leu His Asp Thr Glu Asp Glu 
305                 310                 315                 320 


Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe Asp Asp Val Asp Arg Thr 
                325                 330                 335     


Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys 
            340                 345                 350         


Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
        355                 360                 365         


<210>  45
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys 
1               5                   10                  15      


Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly 
            20                  25                  30          


Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly 
        35                  40                  45              


Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile 
    50                  55                  60                  


Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln 
65                  70                  75                  80  


His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser 
                85                  90                  95      


Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr 
            100                 105                 110         


Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln 
        115                 120                 125             


Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Ala Asp 
                165                 170                 175     


Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu Phe Lys 
    210                 215                 220                 


Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val Thr Gly 
225                 230                 235                 240 


Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala Ala Lys 
                245                 250                 255     


Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe Thr Gln 
            260                 265                 270         


Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala Leu Thr 
    290                 295                 300                 


His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr Glu Ala 
305                 310                 315                 320 


Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr Val Asp 
                325                 330                 335     


Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser Pro Ile 
            340                 345                 350         


Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu 
        355                 360                 365 


<210>  46
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 
    210                 215                 220                 


Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 
    370                 375                 380                 


Asn Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 
385                 390                 395                 400 


Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 
                405                 410                 415     


Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 
            420                 425         


<210>  47
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys Gly Gly Val Leu 
    210                 215                 220                 


Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 
    370                 375                 380                 


Asn Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 
385                 390                 395                 400 


Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 
                405                 410                 415     


Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 
            420                 425         


<210>  48
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys Gly Gly Val Leu 
    210                 215                 220                 


Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 
    370                 375                 380                 


<210>  49
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 
    210                 215                 220                 


Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 
    370                 375                 380                 


<210>  50
<211>  1354
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn 
1               5                   10                  15      


Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp 
            20                  25                  30          


Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys 
        35                  40                  45              


Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn 
    50                  55                  60                  


Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
                85                  90                  95      


Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
            100                 105                 110         


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
        115                 120                 125             


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
145                 150                 155                 160 


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg 
                165                 170                 175     


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
            180                 185                 190         


Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
        195                 200                 205             


Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn 
    210                 215                 220                 


Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
225                 230                 235                 240 


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly 
                245                 250                 255     


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
            260                 265                 270         


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
        275                 280                 285             


Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp 
    290                 295                 300                 


Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
305                 310                 315                 320 


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu 
                325                 330                 335     


Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val 
            340                 345                 350         


Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe 
        355                 360                 365             


Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro 
    370                 375                 380                 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr 
385                 390                 395                 400 


Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr 
                405                 410                 415     


Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile 
            420                 425                 430         


Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu 
        435                 440                 445             


Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met 
    450                 455                 460                 


Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr 
465                 470                 475                 480 


Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn 
                485                 490                 495     


Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val 
            500                 505                 510         


Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys 
        515                 520                 525             


Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr 
545                 550                 555                 560 


Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser 
                565                 570                 575     


Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu 
            580                 585                 590         


Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala 
        595                 600                 605             


Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile 
    610                 615                 620                 


Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His 
625                 630                 635                 640 


Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln 
                645                 650                 655     


Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp 
            660                 665                 670         


Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val 
        675                 680                 685             


Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser 
    690                 695                 700                 


Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu 
705                 710                 715                 720 


Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln 
                725                 730                 735     


Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln 
            740                 745                 750         


Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu 
        755                 760                 765             


Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu 
    770                 775                 780                 


Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu 
785                 790                 795                 800 


Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu 
                805                 810                 815     


Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr 
            820                 825                 830         


Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala 
        835                 840                 845             


Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys 
    850                 855                 860                 


Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu 
865                 870                 875                 880 


Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu 
                885                 890                 895     


Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln 
            900                 905                 910         


Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg 
        915                 920                 925             


Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala 
    930                 935                 940                 


Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu 
945                 950                 955                 960 


Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu 
                965                 970                 975     


Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile 
            980                 985                 990         


Asn Thr Glu Arg Thr Leu Lys Thr  Gln Ala Val Asn Lys  Leu Ala Glu 
        995                 1000                 1005             


Ile Met  Asn Arg Lys Asp Phe  Lys Ile Asp Arg Lys  Lys Ala Asn 
    1010                 1015                 1020             


Thr Gln  Asp Leu Arg Lys Lys  Glu Lys Glu Asn Arg  Lys Leu Gln 
    1025                 1030                 1035             


Leu Glu  Leu Asn Gln Glu Arg  Glu Lys Phe Asn Gln  Met Val Val 
    1040                 1045                 1050             


Lys His  Gln Lys Glu Leu Asn  Asp Met Gln Ala Gln  Leu Val Glu 
    1055                 1060                 1065             


Glu Cys  Ala His Arg Asn Glu  Leu Gln Met Gln Leu  Ala Ser Lys 
    1070                 1075                 1080             


Glu Ser  Asp Ile Glu Gln Leu  Arg Ala Lys Leu Leu  Asp Leu Ser 
    1085                 1090                 1095             


Asp Ser  Thr Ser Val Ala Ser  Phe Pro Ser Ala Asp  Glu Thr Asp 
    1100                 1105                 1110             


Gly Asn  Leu Pro Glu Ser Arg  Ile Glu Gly Trp Leu  Ser Val Pro 
    1115                 1120                 1125             


Asn Arg  Gly Asn Ile Lys Arg  Tyr Gly Trp Lys Lys  Gln Tyr Val 
    1130                 1135                 1140             


Val Val  Ser Ser Lys Lys Ile  Leu Phe Tyr Asn Asp  Glu Gln Asp 
    1145                 1150                 1155             


Lys Glu  Gln Ser Asn Pro Ser  Met Val Leu Asp Ile  Asp Lys Leu 
    1160                 1165                 1170             


Phe His  Val Arg Pro Val Thr  Gln Gly Asp Val Tyr  Arg Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Ile Pro Lys Ile  Phe Gln Ile Leu Tyr  Ala Asn Glu 
    1190                 1195                 1200             


Gly Glu  Cys Arg Lys Asp Val  Glu Met Glu Pro Val  Gln Gln Ala 
    1205                 1210                 1215             


Glu Lys  Thr Asn Phe Gln Asn  His Lys Gly His Glu  Phe Ile Pro 
    1220                 1225                 1230             


Thr Leu  Tyr His Phe Pro Ala  Asn Cys Asp Ala Cys  Ala Lys Pro 
    1235                 1240                 1245             


Leu Trp  His Val Phe Lys Pro  Pro Pro Ala Leu Glu  Cys Arg Arg 
    1250                 1255                 1260             


Cys His  Val Lys Cys His Arg  Asp His Leu Asp Lys  Lys Glu Asp 
    1265                 1270                 1275             


Leu Ile  Cys Pro Cys Lys Val  Ser Tyr Asp Val Thr  Ser Ala Arg 
    1280                 1285                 1290             


Asp Met  Leu Leu Leu Ala Cys  Ser Gln Asp Glu Gln  Lys Lys Trp 
    1295                 1300                 1305             


Val Thr  His Leu Val Lys Lys  Ile Pro Lys Asn Pro  Pro Ser Gly 
    1310                 1315                 1320             


Phe Val  Arg Ala Ser Pro Arg  Thr Leu Ser Thr Arg  Ser Thr Ala 
    1325                 1330                 1335             


Asn Gln  Ser Phe Arg Lys Val  Val Lys Asn Thr Ser  Gly Lys Thr 
    1340                 1345                 1350             


Ser 
    


<210>  51
<211>  1388
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
1               5                   10                  15      


Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
            20                  25                  30          


Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
        35                  40                  45              


Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
    50                  55                  60                  


Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
65                  70                  75                  80  


Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                85                  90                  95      


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
            100                 105                 110         


Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
        115                 120                 125             


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
    130                 135                 140                 


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
145                 150                 155                 160 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                165                 170                 175     


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
            180                 185                 190         


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
        195                 200                 205             


Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
    210                 215                 220                 


His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
225                 230                 235                 240 


Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                245                 250                 255     


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
            260                 265                 270         


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
        275                 280                 285             


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
    290                 295                 300                 


Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                325                 330                 335     


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
            340                 345                 350         


Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
        355                 360                 365             


Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
    370                 375                 380                 


Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
385                 390                 395                 400 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                405                 410                 415     


Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
            420                 425                 430         


Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
        435                 440                 445             


Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
    450                 455                 460                 


Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
465                 470                 475                 480 


Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                485                 490                 495     


Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
            500                 505                 510         


Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
        515                 520                 525             


Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
    530                 535                 540                 


Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
545                 550                 555                 560 


Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                565                 570                 575     


Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
            580                 585                 590         


Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
        595                 600                 605             


Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
    610                 615                 620                 


Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
625                 630                 635                 640 


Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                645                 650                 655     


Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
            660                 665                 670         


Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
        675                 680                 685             


Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
    690                 695                 700                 


Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
705                 710                 715                 720 


Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                725                 730                 735     


Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
            740                 745                 750         


Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
        755                 760                 765             


Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
    770                 775                 780                 


Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
785                 790                 795                 800 


Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                805                 810                 815     


Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
            820                 825                 830         


His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
        835                 840                 845             


Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
    850                 855                 860                 


Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
865                 870                 875                 880 


Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                885                 890                 895     


Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
            900                 905                 910         


Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
        915                 920                 925             


Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
    930                 935                 940                 


Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
945                 950                 955                 960 


Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                965                 970                 975     


Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
            980                 985                 990         


Asn Asn Lys Leu Lys Asp Val Gln  Glu Gln Leu Ser Arg  Leu Lys Asp 
        995                 1000                 1005             


Glu Glu  Ile Ser Ala Ala Ala  Ile Lys Ala Gln Phe  Glu Lys Gln 
    1010                 1015                 1020             


Leu Leu  Thr Glu Arg Thr Leu  Lys Thr Gln Ala Val  Asn Lys Leu 
    1025                 1030                 1035             


Ala Glu  Ile Met Asn Arg Lys  Glu Pro Val Lys Arg  Gly Asn Asp 
    1040                 1045                 1050             


Thr Asp  Val Arg Arg Lys Glu  Lys Glu Asn Arg Lys  Leu His Met 
    1055                 1060                 1065             


Glu Leu  Lys Ser Glu Arg Glu  Lys Leu Thr Gln Gln  Met Ile Lys 
    1070                 1075                 1080             


Tyr Gln  Lys Glu Leu Asn Glu  Met Gln Ala Gln Ile  Ala Glu Glu 
    1085                 1090                 1095             


Ser Gln  Ile Arg Ile Glu Leu  Gln Met Thr Leu Asp  Ser Lys Asp 
    1100                 1105                 1110             


Ser Asp  Ile Glu Gln Leu Arg  Ser Gln Leu Gln Ala  Leu His Ile 
    1115                 1120                 1125             


Gly Leu  Asp Ser Ser Ser Ile  Gly Ser Gly Pro Gly  Asp Ala Glu 
    1130                 1135                 1140             


Ala Asp  Asp Gly Phe Pro Glu  Ser Arg Leu Glu Gly  Trp Leu Ser 
    1145                 1150                 1155             


Leu Pro  Val Arg Asn Asn Thr  Lys Lys Phe Gly Trp  Val Lys Lys 
    1160                 1165                 1170             


Tyr Val  Ile Val Ser Ser Lys  Lys Ile Leu Phe Tyr  Asp Ser Glu 
    1175                 1180                 1185             


Gln Asp  Lys Glu Gln Ser Asn  Pro Tyr Met Val Leu  Asp Ile Asp 
    1190                 1195                 1200             


Lys Leu  Phe His Val Arg Pro  Val Thr Gln Thr Asp  Val Tyr Arg 
    1205                 1210                 1215             


Ala Asp  Ala Lys Glu Ile Pro  Arg Ile Phe Gln Ile  Leu Tyr Ala 
    1220                 1225                 1230             


Asn Glu  Gly Glu Ser Lys Lys  Glu Gln Glu Phe Pro  Val Glu Pro 
    1235                 1240                 1245             


Val Gly  Glu Lys Ser Asn Tyr  Ile Cys His Lys Gly  His Glu Phe 
    1250                 1255                 1260             


Ile Pro  Thr Leu Tyr His Phe  Pro Thr Asn Cys Glu  Ala Cys Met 
    1265                 1270                 1275             


Lys Pro  Leu Trp His Met Phe  Lys Pro Pro Pro Ala  Leu Glu Cys 
    1280                 1285                 1290             


Arg Arg  Cys His Ile Lys Cys  His Lys Asp His Met  Asp Lys Lys 
    1295                 1300                 1305             


Glu Glu  Ile Ile Ala Pro Cys  Lys Val Tyr Tyr Asp  Ile Ser Thr 
    1310                 1315                 1320             


Ala Lys  Asn Leu Leu Leu Leu  Ala Asn Ser Thr Glu  Glu Gln Gln 
    1325                 1330                 1335             


Lys Trp  Val Ser Arg Leu Val  Lys Lys Ile Pro Lys  Lys Pro Pro 
    1340                 1345                 1350             


Ala Pro  Asp Pro Phe Ala Arg  Ser Ser Pro Arg Thr  Ser Met Lys 
    1355                 1360                 1365             


Ile Gln  Gln Asn Gln Ser Ile  Arg Arg Pro Ser Arg  Gln Leu Ala 
    1370                 1375                 1380             


Pro Asn  Lys Pro Ser 
    1385             


<210>  52
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  SiRNA oligonucleotide

<400>  52
aggucaaggg caagcccgac cugaa                                             25


<210>  53
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  SiRNA oligonucleotide

<400>  53
uucaggucgg gcuugcccuu gaccu                                             25


<210>  54
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  55
<211>  1411
<212>  DNA
<213>  Homo sapiens

<400>  55
ccttcgcaag ccctcatttc accaggcccc cggcttgggg cgccttcctt ccccatggcg       60

ggacacctgg cttcggattt cgccttctcg ccccctccag gtggtggagg tgatgggcca      120

ggggggccgg agccgggctg ggttgatcct cggacctggc taagcttcca aggccctcct      180

ggagggccag gaatcgggcc gggggttggg ccaggctctg aggtgtgggg gattccccca      240

tgccccccgc cgtatgagtt ctgtgggggg atggcgtact gtgggcccca ggttggagtg      300

gggctagtgc cccaaggcgg cttggagacc tctcagcctg agggcgaagc aggagtcggg      360

gtggagagca actccgatgg ggcctccccg gagccctgca ccgtcacccc tggtgccgtg      420

aagctggaga aggagaagct ggagcaaaac ccggaggagt cccaggacat caaagctctg      480

cagaaagaac tcgagcaatt tgccaagctc ctgaagcaga agaggatcac cctgggatat      540

acacaggccg atgtggggct caccctgggg gttctatttg ggaaggtatt cagccaaacg      600

accatctgcc gctttgaggc tctgcagctt agcttcaaga acatgtgtaa gctgcggccc      660

ttgctgcaga agtgggtgga ggaagctgac aacaatgaaa atcttcagga gatatgcaaa      720

gcagaaaccc tcgtgcaggc ccgaaagaga aagcgaacca gtatcgagaa ccgagtgaga      780

ggcaacctgg agaatttgtt cctgcagtgc ccgaaaccca cactgcagca gatcagccac      840

atcgcccagc agcttgggct cgagaaggat gtggtccgag tgtggttctg taaccggcgc      900

cagaagggca agcgatcaag cagcgactat gcacaacgag aggattttga ggctgctggg      960

tctcctttct cagggggacc agtgtccttt cctctggccc cagggcccca ttttggtacc     1020

ccaggctatg ggagccctca cttcactgca ctgtactcct cggtcccttt ccctgagggg     1080

gaagcctttc cccctgtctc cgtcaccact ctgggctctc ccatgcattc aaactgaggt     1140

gcctgccctt ctaggaatgg gggacagggg gaggggagga gctagggaaa gaaaacctgg     1200

agtttgtgcc agggtttttg ggattaagtt cttcattcac taaggaagga attgggaaca     1260

caaagggtgg gggcagggga gtttggggca actggttgga gggaaggtga agttcaatga     1320

tgctcttgat tttaatccca catcatgtat cacttttttc ttaaataaag aagcctggga     1380

cacagtagat agacacactt aaaaaaaaaa a                                    1411


<210>  56
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  57
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  57
ggatggttgt ctattaactt gttcaaaaaa gtatcaggag ttgtcaaggc agagaagaga       60

gtgtttgcaa aagggggaaa gtagtttgct gcctctttaa gactaggact gagagaaaga      120

agaggagaga gaaagaaagg gagagaagtt tgagccccag gcttaagcct ttccaaaaaa      180

taataataac aatcatcggc ggcggcagga tcggccagag gaggagggaa gcgctttttt      240

tgatcctgat tccagtttgc ctctctcttt ttttccccca aattattctt cgcctgattt      300

tcctcgcgga gccctgcgct cccgacaccc ccgcccgcct cccctcctcc tctccccccg      360

cccgcgggcc ccccaaagtc ccggccgggc cgagggtcgg cggccgccgg cgggccgggc      420

ccgcgcacag cgcccgcatg tacaacatga tggagacgga gctgaagccg ccgggcccgc      480

agcaaacttc ggggggcggc ggcggcaact ccaccgcggc ggcggccggc ggcaaccaga      540

aaaacagccc ggaccgcgtc aagcggccca tgaatgcctt catggtgtgg tcccgcgggc      600

agcggcgcaa gatggcccag gagaacccca agatgcacaa ctcggagatc agcaagcgcc      660

tgggcgccga gtggaaactt ttgtcggaga cggagaagcg gccgttcatc gacgaggcta      720

agcggctgcg agcgctgcac atgaaggagc acccggatta taaataccgg ccccggcgga      780

aaaccaagac gctcatgaag aaggataagt acacgctgcc cggcgggctg ctggcccccg      840

gcggcaatag catggcgagc ggggtcgggg tgggcgccgg cctgggcgcg ggcgtgaacc      900

agcgcatgga cagttacgcg cacatgaacg gctggagcaa cggcagctac agcatgatgc      960

aggaccagct gggctacccg cagcacccgg gcctcaatgc gcacggcgca gcgcagatgc     1020

agcccatgca ccgctacgac gtgagcgccc tgcagtacaa ctccatgacc agctcgcaga     1080

cctacatgaa cggctcgccc acctacagca tgtcctactc gcagcagggc acccctggca     1140

tggctcttgg ctccatgggt tcggtggtca agtccgaggc cagctccagc ccccctgtgg     1200

ttacctcttc ctcccactcc agggcgccct gccaggccgg ggacctccgg gacatgatca     1260

gcatgtatct ccccggcgcc gaggtgccgg aacccgccgc ccccagcaga cttcacatgt     1320

cccagcacta ccagagcggc ccggtgcccg gcacggccat taacggcaca ctgcccctct     1380

cacacatgtg agggccggac agcgaactgg aggggggaga aattttcaaa gaaaaacgag     1440

ggaaatggga ggggtgcaaa agaggagagt aagaaacagc atggagaaaa cccggtacgc     1500

tcaaaaagaa aaaggaaaaa aaaaaatccc atcacccaca gcaaatgaca gctgcaaaag     1560

agaacaccaa tcccatccac actcacgcaa aaaccgcgat gccgacaaga aaacttttat     1620

gagagagatc ctggacttct ttttggggga ctatttttgt acagagaaaa cctggggagg     1680

gtggggaggg cgggggaatg gaccttgtat agatctggag gaaagaaagc tacgaaaaac     1740

tttttaaaag ttctagtggt acggtaggag ctttgcagga agtttgcaaa agtctttacc     1800

aataatattt agagctagtc tccaagcgac gaaaaaaatg ttttaatatt tgcaagcaac     1860

ttttgtacag tatttatcga gataaacatg gcaatcaaaa tgtccattgt ttataagctg     1920

agaatttgcc aatatttttc aaggagaggc ttcttgctga attttgattc tgcagctgaa     1980

atttaggaca gttgcaaacg tgaaaagaag aaaattattc aaatttggac attttaattg     2040

tttaaaaatt gtacaaaagg aaaaaattag aataagtact ggcgaaccat ctctgtggtc     2100

ttgtttaaaa agggcaaaag ttttagactg tactaaattt tataacttac tgttaaaagc     2160

aaaaatggcc atgcaggttg acaccgttgg taatttataa tagcttttgt tcgatcccaa     2220

ctttccattt tgttcagata aaaaaaacca tgaaattact gtgtttgaaa tattttctta     2280

tggtttgtaa tatttctgta aatttattgt gatattttaa ggttttcccc cctttatttt     2340

ccgtagttgt attttaaaag attcggctct gtattatttg aatcagtctg ccgagaatcc     2400

atgtatatat ttgaactaat atcatcctta taacaggtac attttcaact taagttttta     2460

ctccattatg cacagtttga gataaataaa tttttgaaat atggacactg aaaaaaaaaa     2520


<210>  58
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  59
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  59
agtttcccga ccagagagaa cgaacgtgtc tgcgggcgcg cggggagcag aggcggtggc       60

gggcggcggc ggcaccggga gccgccgagt gaccctcccc cgcccctctg gccccccacc      120

ctcccacccg cccgtggccc gcgcccatgg ccgcgcgcgc tccacacaac tcaccggagt      180

ccgcgccttg cgccgccgac cagttcgcag ctccgcgcca cggcagccag tctcacctgg      240

cggcaccgcc cgcccaccgc cccggccaca gcccctgcgc ccacggcagc actcgaggcg      300

accgcgacag tggtggggga cgctgctgag tggaagagag cgcagcccgg ccaccggacc      360

tacttactcg ccttgctgat tgtctatttt tgcgtttaca acttttctaa gaacttttgt      420

atacaaagga actttttaaa aaagacgctt ccaagttata tttaatccaa agaagaagga      480

tctcggccaa tttggggttt tgggttttgg cttcgtttct tctcttcgtt gactttgggg      540

ttcaggtgcc ccagctgctt cgggctgccg aggaccttct gggcccccac attaatgagg      600

cagccacctg gcgagtctga catggctgtc agcgacgcgc tgctcccatc tttctccacg      660

ttcgcgtctg gcccggcggg aagggagaag acactgcgtc aagcaggtgc cccgaataac      720

cgctggcggg aggagctctc ccacatgaag cgacttcccc cagtgcttcc cggccgcccc      780

tatgacctgg cggcggcgac cgtggccaca gacctggaga gcggcggagc cggtgcggct      840

tgcggcggta gcaacctggc gcccctacct cggagagaga ccgaggagtt caacgatctc      900

ctggacctgg actttattct ctccaattcg ctgacccatc ctccggagtc agtggccgcc      960

accgtgtcct cgtcagcgtc agcctcctct tcgtcgtcgc cgtcgagcag cggccctgcc     1020

agcgcgccct ccacctgcag cttcacctat ccgatccggg ccgggaacga cccgggcgtg     1080

gcgccgggcg gcacgggcgg aggcctcctc tatggcaggg agtccgctcc ccctccgacg     1140

gctcccttca acctggcgga catcaacgac gtgagcccct cgggcggctt cgtggccgag     1200

ctcctgcggc cagaattgga cccggtgtac attccgccgc agcagccgca gccgccaggt     1260

ggcgggctga tgggcaagtt cgtgctgaag gcgtcgctga gcgcccctgg cagcgagtac     1320

ggcagcccgt cggtcatcag cgtcagcaaa ggcagccctg acggcagcca cccggtggtg     1380

gtggcgccct acaacggcgg gccgccgcgc acgtgcccca agatcaagca ggaggcggtc     1440

tcttcgtgca cccacttggg cgctggaccc cctctcagca atggccaccg gccggctgca     1500

cacgacttcc ccctggggcg gcagctcccc agcaggacta ccccgaccct gggtcttgag     1560

gaagtgctga gcagcaggga ctgtcaccct gccctgccgc ttcctcccgg cttccatccc     1620

cacccggggc ccaattaccc atccttcctg cccgatcaga tgcagccgca agtcccgccg     1680

ctccattacc aagagctcat gccacccggt tcctgcatgc cagaggagcc caagccaaag     1740

aggggaagac gatcgtggcc ccggaaaagg accgccaccc acacttgtga ttacgcgggc     1800

tgcggcaaaa cctacacaaa gagttcccat ctcaaggcac acctgcgaac ccacacaggt     1860

gagaaacctt accactgtga ctgggacggc tgtggatgga aattcgcccg ctcagatgaa     1920

ctgaccaggc actaccgtaa acacacgggg caccgcccgt tccagtgcca aaaatgcgac     1980

cgagcatttt ccaggtcgga ccacctcgcc ttacacatga agaggcattt ttaaatccca     2040

gacagtggat atgacccaca ctgccagaag agaattcagt attttttact tttcacactg     2100

tcttcccgat gagggaagga gcccagccag aaagcactac aatcatggtc aagttcccaa     2160

ctgagtcatc ttgtgagtgg ataatcagga aaaatgagga atccaaaaga caaaaatcaa     2220

agaacagatg gggtctgtga ctggatcttc tatcattcca attctaaatc cgacttgaat     2280

attcctggac ttacaaaatg ccaagggggt gactggaagt tgtggatatc agggtataaa     2340

ttatatccgt gagttggggg agggaagacc agaattccct tgaattgtgt attgatgcaa     2400

tataagcata aaagatcacc ttgtattctc tttaccttct aaaagccatt attatgatgt     2460

tagaagaaga ggaagaaatt caggtacaga aaacatgttt aaatagccta aatgatggtg     2520

cttggtgagt cttggttcta aaggtaccaa acaaggaagc caaagttttc aaactgctgc     2580

atactttgac aaggaaaatc tatatttgtc ttccgatcaa catttatgac ctaagtcagg     2640

taatatacct ggtttacttc tttagcattt ttatgcagac agtctgttat gcactgtggt     2700

ttcagatgtg caataatttg tacaatggtt tattcccaag tatgccttaa gcagaacaaa     2760

tgtgtttttc tatatagttc cttgccttaa taaatatgta atataaattt aagcaaacgt     2820

ctattttgta tatttgtaaa ctacaaagta aaatgaacat tttgtggagt ttgtattttg     2880

catactcaag gtgagaatta agttttaaat aaacctataa tattttatct gaaaaaaaaa     2940

aaaaaaaaa                                                             2949


<210>  60
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  61
<211>  2379
<212>  DNA
<213>  Homo sapiens

<400>  61
gacccccgag ctgtgctgct cgcggccgcc accgccgggc cccggccgtc cctggctccc       60

ctcctgcctc gagaagggca gggcttctca gaggcttggc gggaaaaaga acggagggag      120

ggatcgcgct gagtataaaa gccggttttc ggggctttat ctaactcgct gtagtaattc      180

cagcgagagg cagagggagc gagcgggcgg ccggctaggg tggaagagcc gggcgagcag      240

agctgcgctg cgggcgtcct gggaagggag atccggagcg aatagggggc ttcgcctctg      300

gcccagccct cccgctgatc ccccagccag cggtccgcaa cccttgccgc atccacgaaa      360

ctttgcccat agcagcgggc gggcactttg cactggaact tacaacaccc gagcaaggac      420

gcgactctcc cgacgcgggg aggctattct gcccatttgg ggacacttcc ccgccgctgc      480

caggacccgc ttctctgaaa ggctctcctt gcagctgctt agacgctgga tttttttcgg      540

gtagtggaaa accagcagcc tcccgcgacg atgcccctca acgttagctt caccaacagg      600

aactatgacc tcgactacga ctcggtgcag ccgtatttct actgcgacga ggaggagaac      660

ttctaccagc agcagcagca gagcgagctg cagcccccgg cgcccagcga ggatatctgg      720

aagaaattcg agctgctgcc caccccgccc ctgtccccta gccgccgctc cgggctctgc      780

tcgccctcct acgttgcggt cacacccttc tcccttcggg gagacaacga cggcggtggc      840

gggagcttct ccacggccga ccagctggag atggtgaccg agctgctggg aggagacatg      900

gtgaaccaga gtttcatctg cgacccggac gacgagacct tcatcaaaaa catcatcatc      960

caggactgta tgtggagcgg cttctcggcc gccgccaagc tcgtctcaga gaagctggcc     1020

tcctaccagg ctgcgcgcaa agacagcggc agcccgaacc ccgcccgcgg ccacagcgtc     1080

tgctccacct ccagcttgta cctgcaggat ctgagcgccg ccgcctcaga gtgcatcgac     1140

ccctcggtgg tcttccccta ccctctcaac gacagcagct cgcccaagtc ctgcgcctcg     1200

caagactcca gcgccttctc tccgtcctcg gattctctgc tctcctcgac ggagtcctcc     1260

ccgcagggca gccccgagcc cctggtgctc catgaggaga caccgcccac caccagcagc     1320

gactctgagg aggaacaaga agatgaggaa gaaatcgatg ttgtttctgt ggaaaagagg     1380

caggctcctg gcaaaaggtc agagtctgga tcaccttctg ctggaggcca cagcaaacct     1440

cctcacagcc cactggtcct caagaggtgc cacgtctcca cacatcagca caactacgca     1500

gcgcctccct ccactcggaa ggactatcct gctgccaaga gggtcaagtt ggacagtgtc     1560

agagtcctga gacagatcag caacaaccga aaatgcacca gccccaggtc ctcggacacc     1620

gaggagaatg tcaagaggcg aacacacaac gtcttggagc gccagaggag gaacgagcta     1680

aaacggagct tttttgccct gcgtgaccag atcccggagt tggaaaacaa tgaaaaggcc     1740

cccaaggtag ttatccttaa aaaagccaca gcatacatcc tgtccgtcca agcagaggag     1800

caaaagctca tttctgaaga ggacttgttg cggaaacgac gagaacagtt gaaacacaaa     1860

cttgaacagc tacggaactc ttgtgcgtaa ggaaaagtaa ggaaaacgat tccttctaac     1920

agaaatgtcc tgagcaatca cctatgaact tgtttcaaat gcatgatcaa atgcaacctc     1980

acaaccttgg ctgagtcttg agactgaaag atttagccat aatgtaaact gcctcaaatt     2040

ggactttggg cataaaagaa cttttttatg cttaccatct tttttttttc tttaacagat     2100

ttgtatttaa gaattgtttt taaaaaattt taagatttac acaatgtttc tctgtaaata     2160

ttgccattaa atgtaaataa ctttaataaa acgtttatag cagttacaca gaatttcaat     2220

cctagtatat agtacctagt attataggta ctataaaccc taattttttt tatttaagta     2280

cattttgctt tttaaagttg atttttttct attgttttta gaaaaaataa aataactggc     2340

aaatatatca ttgagccaaa tcttaaaaaa aaaaaaaaa                            2379


<210>  62
<211>  5489
<212>  DNA
<213>  Artificial sequence

<220>
<223>  OSKM expression cassette: OCT4-F2A-KLF4-IRES-SOX2-E2A SEQUENCE

<400>  62
atggctggac acctggcttc agacttcgcc ttctcacccc caccaggtgg gggtgatggg       60

tcagcagggc tggagccggg ctgggtggat cctcgaacct ggctaagctt ccaagggcct      120

ccaggtgggc ctggaatcgg accaggctca gaggtattgg ggatctcccc atgtccgccc      180

gcatacgagt tctgcggagg gatggcatac tgtggacctc aggttggact gggcctagtc      240

ccccaagttg gcgtggagac tttgcagcct gagggccagg caggagcacg agtggaaagc      300

aactcagagg gaacctcctc tgagccctgt gccgaccgcc ccaatgccgt gaagttggag      360

aaggtggaac caactcccga ggagtcccag gacatgaaag ccctgcagaa ggagctagaa      420

cagtttgcca agctgctgaa gcagaagagg atcaccttgg ggtacaccca ggccgacgtg      480

gggctcaccc tgggcgttct ctttggaaag gtgttcagcc agaccaccat ctgtcgcttc      540

gaggccttgc agctcagcct taagaacatg tgtaagctgc ggcccctgct ggagaagtgg      600

gtggaggaag ccgacaacaa tgagaacctt caggagatat gcaaatcgga gaccctggtg      660

caggcccgga agagaaagcg aactagcatt gagaaccgtg tgaggtggag tctggagacc      720

atgtttctga agtgcccgaa gccctcccta cagcagatca ctcacatcgc caatcagctt      780

gggctagaga aggatgtggt tcgagtatgg ttctgtaacc ggcgccagaa gggcaaaaga      840

tcaagtattg agtattccca acgagaagag tatgaggcta cagggacacc tttcccaggg      900

ggggctgtat cctttcctct gcccccaggt ccccactttg gcaccccagg ctatggaagc      960

ccccacttca ccacactcta ctcagtccct tttcctgagg gcgaggcctt tccctctgtt     1020

cccgtcactg ctctgggctc tcccatgcat tcaaacggaa gtggcgtgaa acagactttg     1080

aattttgacc ttctcaagtt ggcgggagac gtggagtcca acccagggcc catggctgtc     1140

agcgacgctc tgctcccgtc cttctccacg ttcgcgtccg gcccggcggg aagggagaag     1200

acactgcgtc cagcaggtgc cccgactaac cgttggcgtg aggaactctc tcacatgaag     1260

cgacttcccc cacttcccgg ccgcccctac gacctggcgg cgacggtggc cacagacctg     1320

gagagtggcg gagctggtgc agcttgcagc agtaacaacc cggccctcct agcccggagg     1380

gagaccgagg agttcaacga cctcctggac ctagacttta tcctttccaa ctcgctaacc     1440

caccaggaat cggtggccgc caccgtgacc acctcggcgt cagcttcatc ctcgtcttcc     1500

ccagcgagca gcggccctgc cagcgcgccc tccacctgca gcttcagcta tccgatccgg     1560

gccgggggtg acccgggcgt ggctgccagc aacacaggtg gagggctcct ctacagccga     1620

gaatctgcgc cacctcccac ggcccccttc aacctggcgg acatcaatga cgtgagcccc     1680

tcgggcggct tcgtggctga gctcctgcgg ccggagttgg acccagtata cattccgcca     1740

cagcagcctc agccgccagg tggcgggctg atgggcaagt ttgtgctgaa ggcgtctctg     1800

accacccctg gcagcgagta cagcagccct tcggtcatca gtgttagcaa aggaagccca     1860

gacggcagcc accccgtggt agtggcgccc tacagcggtg gcccgccgcg catgtgcccc     1920

aagattaagc aagaggcggt cccgtcctgc acggtcagcc ggtccctaga ggcccatttg     1980

agcgctggac cccagctcag caacggccac cggcccaaca cacacgactt ccccctgggg     2040

cggcagctcc ccaccaggac tacccctaca ctgagtcccg aggaactgct gaacagcagg     2100

gactgtcacc ctggcctgcc tcttccccca ggattccatc cccatccggg gcccaactac     2160

cctcctttcc tgccagacca gatgcagtca caagtcccct ctctccatta tcaagagctc     2220

atgccaccgg gttcctgcct gccagaggag cccaagccaa agaggggaag aaggtcgtgg     2280

ccccggaaaa gaacagccac ccacacttgt gactatgcag gctgtggcaa aacctatacc     2340

aagagttctc atctcaaggc acacctgcga actcacacag gcgagaaacc ttaccactgt     2400

gactgggacg gctgtgggtg gaaattcgcc cgctccgatg aactgaccag gcactaccgc     2460

aaacacacag ggcaccggcc ctttcagtgc cagaagtgtg acagggcctt ttccaggtcg     2520

gaccaccttg ccttacacat gaagaggcac ttttaaagat ccctcccccc cccctaacgt     2580

tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac     2640

catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag     2700

cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa     2760

ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag     2820

gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga     2880

tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag     2940

agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc     3000

ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg tttagtcgag     3060

gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg     3120

atgataatat ggccacacat atgatgtata acatgatgga gacggagctg aagccgccgg     3180

gcccgcagca agcttcgggg ggcggcggcg gaggaggcaa cgccacggcg gcggcgaccg     3240

gcggcaacca gaagaacagc ccggaccgcg tcaagaggcc catgaacgcc ttcatggtat     3300

ggtcccgggg gcagcggcgt aagatggccc aggagaaccc caagatgcac aactcggaga     3360

tcagcaagcg cctgggcgcg gagtggaaac ttttgtccga gaccgagaag cggccgttca     3420

tcgacgaggc caagcggctg cgcgctctgc acatgaagga gcacccggat tataaatacc     3480

ggccgcggcg gaaaaccaag acgctcatga agaaggataa gtacacgctt cccggaggct     3540

tgctggcccc cggcgggaac agcatggcga gcggggttgg ggtgggcgcc ggcctgggtg     3600

cgggcgtgaa ccagcgcatg gacagctacg cgcacatgaa cggctggagc aacggcagct     3660

acagcatgat gcaggagcag ctgggctacc cgcagcaccc gggcctcaac gctcacggcg     3720

cggcacagat gcaaccgatg caccgctacg acgtcagcgc cctgcagtac aactccatga     3780

ccagctcgca gacctacatg aacggctcgc ccacctacag catgtcctac tcgcagcagg     3840

gcacccccgg tatggcgctg ggctccatgg gctctgtggt caagtccgag gccagctcca     3900

gcccccccgt ggttacctct tcctcccact ccagggcgcc ctgccaggcc ggggacctcc     3960

gggacatgat cagcatgtac ctccccggcg ccgaggtgcc ggagcccgct gcgcccagta     4020

gactgcacat ggcccagcac taccagagcg gcccggtgcc cggcacggcc attaacggca     4080

cactgcccct gtcgcacatg ggtagtgggc aatgtactaa ctacgctttg ttgaaactcg     4140

ctggcgatgt tgaaagtaac cccggtccta tgcccctcaa cgtgaacttc accaacagga     4200

actatgacct cgactacgac tccgtacagc cctatttcat ctgcgacgag gaagagaatt     4260

tctatcacca gcaacagcag agcgagctgc agccgcccgc gcccagtgag gatatctgga     4320

agaaattcga gctgcttccc accccgcccc tgtccccgag ccgccgctcc gggctctgct     4380

ctccatccta tgttgcggtc gctacgtcct tctccccaag ggaagacgat gacggcggcg     4440

gtggcaactt ctccaccgcc gatcagctgg agatgatgac cgagttactt ggaggagaca     4500

tggtgaacca gagcttcatc tgcgatcctg acgacgagac cttcatcaag aacatcatca     4560

tccaggactg tatgtggagc ggtttctcag ccgctgccaa gctggtctcg gagaagctgg     4620

cctcctacca ggctgcgcgc aaagacagca ccagcctgag ccccgcccgc gggcacagcg     4680

tctgctccac ctccagcctg tacctgcagg acctcaccgc cgccgcgtcc gagtgcattg     4740

acccctcagt ggtctttccc tacccgctca acgacagcag ctcgcccaaa tcctgtacct     4800

cgtccgattc cacggccttc tctccttcct cggactcgct gctgtcctcc gagtcctccc     4860

cacgggccag ccctgagccc ctagtgctgc atgaggagac accgcccacc accagcagcg     4920

actctgaaga agagcaagaa gatgaggaag aaattgatgt ggtgtctgtg gagaagaggc     4980

aaacccctgc caagaggtcg gagtcgggct catctccatc ccgaggccac agcaaacctc     5040

cgcacagccc actggtcctc aagaggtgcc acgtctccac tcaccagcac aactacgccg     5100

cacccccctc cacaaggaag gactatccag ctgccaagag ggccaagttg gacagtggca     5160

gggtcctgaa gcagatcagc aacaaccgca agtgctccag ccccaggtcc tcagacacgg     5220

aggaaaacga caagaggcgg acacacaacg tcttggaacg tcagaggagg aacgagctga     5280

agcgcagctt ttttgccctg cgtgaccaga tccctgaatt ggaaaacaac gaaaaggccc     5340

ccaaggtagt gatcctcaaa aaagccaccg cctacatcct gtccattcaa gcagacgagc     5400

acaagctcac ctctgaaaag gacttattga ggaaacgacg agaacagttg aaacacaaac     5460

tcgaacagct tcgaaactct ggtgcataa                                       5489


<210>  63
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  63
ccggctaagt ggattgagtg cctttctcga gaaaggcact caatccactt agtttttg         58


<210>  64
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  64
aattcaaaaa ctaagtggat tgagtgcctt tctcgagaaa ggcactcaat ccacttag         58


<210>  65
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  65
ccgggcgcta tgattcttcc aaccactcga gtggttggaa gaatcatagc gctttttg         58


<210>  66
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  66
aattcaaaaa gcgctatgat tcttccaacc actcgagtgg ttggaagaat catagcgc         58


<210>  67
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  67
acaactaacc taaaccaaat tataca                                            26


<210>  68
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  68
tgtttttttg tttatcgggg tcgcg                                             25


<210>  69
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  69
cgaattatac gacaaatcta aaataacg                                          28


<210>  70
<211>  203
<212>  DNA
<213>  Artificial sequence

<220>
<223>  203bp amplicon covering human XIST transcription start site

<400>  70
gggtaaattt tgaaccaacc aaatcacaaa gatgtccggc tttcaatctt ctaggccacg       60

cctcttatgc tctctccgcc ctcagccccc ccttcagttc ttaaagcgct gcaattcgct      120

gctgcagcca tatttcttac tctctcgggg ctggaagctt cctgactgaa gatctgttct      180

agaaagaacc ccaagtgcag aga                                              203


<210>  71
<211>  1902
<212>  DNA
<213>  Homo sapiens

<400>  71
atgaccgaag aagcatgccg aacacggagt cagaaacgag cgcttgaacg ggacccaaca       60

gaggacgatg tggagagcaa gaaaataaaa atggagagag gattgttggc ttcagattta      120

aacactgacg gagacatgag ggtgacacct gagccgggag caggtccaac ccaaggattg      180

ctgagggcaa cagaggccac ggccatggcc atgggcagag gcgaagggct ggtgggcgat      240

gggcccgtgg acatgcgcac ctcacacagt gacatgaagt ccgagaggag acccccctca      300

cctgacgtga ttgtgctctc cgacaacgag cagccctcga gcccgagagt gaatgggctg      360

accacggtgg ccttgaagga gactagcacc gaggccctca tgaaaagcag tcctgaagaa      420

cgagaaagga tgatcaagca gctgaaggaa gaattgaggt tagaagaagc aaaactcgtg      480

ttgttgaaaa agttgcggca gagtcaaata caaaaggaag ccaccgccca gaagcccaca      540

ggttctgttg ggagcaccgt gaccacccct cccccgcttg ttcggggcac tcagaacatt      600

cctgctggca agccatcact ccagacctct tcagctcgga tgcccggcag tgtcataccc      660

ccgcccctgg tccgaggtgg gcagcaggcg tcctcgaagc tggggccaca ggcgagctca      720

caggtcgtca tgcccccact cgtcaggggg gctcagcaaa tccacagcat taggcaacat      780

tccagcacag ggccaccgcc cctcctcctg gccccccggg cgtcggtgcc cagtgtgcag      840

attcagggac agaggatcat ccagcagggc ctcatccgcg tcgccaatgt tcccaacacc      900

agcctgctcg tcaacatccc acagcccacc ccagcatcac tgaaggggac aacagccacc      960

tccgctcagg ccaactccac ccccactagt gtggcctctg tggtcacctc tgccgagtct     1020

ccagcaagcc gacaggcggc cgccaagctg gcgctgcgca aacagctgga gaagacgcta     1080

ctcgagatcc ccccacccaa gcccccagcc ccagagatga acttcctgcc cagcgccgcc     1140

aacaacgagt tcatctacct ggtcggcctg gaggaggtgg tgcagaacct actggagaca     1200

caaggcagga tgtcggccgc cactgtgctg tcccgggagc cctacatgtg tgcacagtgc     1260

aagacggact tcacgtgccg ctggcgggag gagaagagcg gcgccatcat gtgtgagaac     1320

tgcatgacaa ccaaccagaa gaaggcgctc aaggtggagc acaccagccg gctgaaggcc     1380

gcctttgtga aggcgctgca gcaggaacag gagattgagc agcggctcct gcagcagggc     1440

acggcccctg cacaggccaa ggccgagccc accgctgccc cacaccccgt gctgaagcag     1500

gtcataaaac cccggcgtaa gttggcgttc cgctcaggag aggcccgcga ctggagtaac     1560

ggggctgtgc tacaggcctc cagccagctg tcccggggtt cggccacgac gccccgaggt     1620

gtcctgcaca cgttcagtcc gtcacccaaa ctgcagaact cagcctcggc cacagccctg     1680

gtcagcagga ccggcagaca ttctgagaga accgtgagcg ccggcaaggg cagcgccacc     1740

tccaactgga agaagacgcc cctcagcaca ggcgggaccc ttgcgtttgt cagcccaagc     1800

ctggcggtgc acaagagctc ctcggccgtg gaccgccagc gagagtacct cctggacatg     1860

atcccacccc gctccatccc ccagtcagcc acgtggaaat ag                        1902


<210>  72
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  72
cagggctgaa gagaagatgg                                                   20


<210>  73
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  73
acaggaggtg ggaatctga                                                    19


<210>  74
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  74
ggtaccggat actcaggcca ggcccagaaa                                        30


<210>  75
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  75
ctcgagtcca cagacctctg gcact                                             25


<210>  76
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  76
ggtacccatt gagtccaaat cctctttact aggtg                                  35


<210>  77
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  77
ctcgagctga ggctcatgct gctgg                                             25


<210>  78
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  78
agggagcagt ttgccctact                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  79
cacatgcagc gtggtatctt                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  80
agtgattctc ctgcctcagc                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  81
cttctgcttc aggagcttgg                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  82
ggaatgggag gacaggattt                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  83
aacagccgga gcagaagata                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  84
aaggatgttg aacgggcaga                                                   20


<210>  85
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  85
tccgttggaa ctgatgga                                                     18


<210>  86
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  86
tgacactggc aaaacaatgc a                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  87
ggtccttttc accagcaagc t                                                 21


<210>  88
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  88
cgccaccaaa ctgagatgat                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  89
cacattgtag tgggcagtgg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  90
cagtcgctac atcaccatcc                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  91
tttcctctcc tttgctctgc                                                   20


<210>  92
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  92
aactcaagaa ggcggatgg                                                    19


<210>  93
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  93
cggtgcgtcc tttaatcct                                                    19


<210>  94
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  94
cgcctcggct acaacaacta                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  95
cgcctcggct acaacaacta                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  96
aaacgtgctg ctctacgaca                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  97
tagtcgatga cgtgctggag                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  98
ctacagcgcg tcatcgacta                                                   20


<210>  99
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  99
tcgttggaga tgacaagttc c                                                 21


<210>  100
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  100
gcgctccgag aatttaaaga                                                   20


<210>  101
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  101
gtcgctgctg ttagcgaag                                                    19


<210>  102
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  102
gatttgtggg cctgaagaaa                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  103
cagatccatg gaggaaggaa                                                   20


<210>  104
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  104
agctgctgga gctcgtctt                                                    19


<210>  105
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  105
cgcctgttct ggaaccatac                                                   20


<210>  106
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  106
taaattttaa attaattaaa ttat                                              24


<210>  107
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  107
tgttttagaa agaattttaa gtgtagaga                                         29


<210>  108
<211>  2457
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  1st exon

<220>
<221>  misc_feature
<222>  (531)..(536)
<223>  Premature polyA signal

<220>
<221>  misc_feature
<222>  (1033)..(1038)
<223>  Premature polyA signal

<220>
<221>  misc_feature
<222>  (1051)..(1056)
<223>  Premature polyA signal

<220>
<221>  misc_feature
<222>  (1569)..(1574)
<223>  Premature polyA signal

<220>
<221>  misc_feature
<222>  (1669)..(2457)
<223>  2nd exon

<220>
<221>  misc_feature
<222>  (1712)..(1714)
<223>  Putative translation start site

<400>  108
accgtcgggg acccccaagc tccgtcctcc gcttcctgct ctctttatcc cgcccccgct       60

ccttctgggc caacgccgcc agtgactatt cccagggatc cctcagagct gaggacgccg      120

cggccgcatc cccatttggg accttgcccc gactccgacc tccggatctc cagctccacc      180

aaacctcgaa gccaccatcc gcccccaaac tgccgctgcg ccaggctttc ggaggggagt      240

cgtggcaaca gccattagga tgcactaagc agggcacttc ctgagcccaa ggacaccgag      300

gggcattcac tgagtgaatg gggatgtgct gctaataact aacactaatt gaccacctgc      360

cgtgtgccca tcctcttcga acatgcaact tccttgttcc ttatcttgtt actgtctctt      420

tctctctgcc agaatccaat cctcacaagg gcagggactg gggtctgttt tgttaactgc      480

catatcacaa tgcctggcac gaaggaagat tcttgaatta atgaatggag attaaattat      540

aatttaaaag cctggcatga actgagcacc ttctgcatgc ttatcacccg ctactgacat      600

atagttcact tttttttttt tttttttttt gagacggagt tttgctctta tctcccaggc      660

tggagtgcaa gtggtgtgat ctcagctcac tgcaacctcc gcctcccggg ttcaagcgat      720

tcttctgcct cagcctcccg agtagctggg attacaggcg tccaccacca ctcctggcta      780

atttttttgt gtttttatta gagacagggt ttcgcaatgt tgggcaggct ggtctcgaac      840

tcctgacctc aggtgatcca cccgactcgg cctccaaagt gctgggatta caggcgtgag      900

ccattgtgcc ccgccccctt tttaacctag tttgttgtct ctcaccccga ccagaatata      960

accttcatga gggctacagt ttgttgtcta tttattgccc aactccatgt ccttgccaca     1020

cagtaggttc ccaataaatg tatgttgaat aattaataaa gactacattc taatgataat     1080

ggctaacaga ccacgtgatt tacatattta tttggtttat tatattatct gcctctgcct     1140

tttagaacat aaaccttctg ggggtgggaa tgttgggtcc ctactgtctg gcaggcactg     1200

tgctgggcta gggttcaatg gtgaccaaaa ccggcaaaat cctgccctcc ctctgtcatg     1260

gggaggaact gctaatgggc atggggattc ttttctgggt gaggaaaatg ttctaaaatt     1320

tacttatggt gatagttgca caacttcgtg aatatgctaa aacccgttaa attggacact     1380

agctggctga acttgatggg atgtaaatta catctcaata aagctgtttg ggaaatccag     1440

ccttcacagt tgttgattcg cgtgaggagg gaaggagaga tggggggacg tgggacaggg     1500

agaaaacaac ataaatcata tatatatagc atgcaaattg gaaggtgatc agcacacaat     1560

aggcattcaa taaatgttga aataatgaca ccccactgtc tccttgccct caaatggtct     1620

cccctaacgt atcccctgtt gtcttgcttc ttctcttccc acttgcagag cctgctgccc     1680

acgtctcttc cctgagctgc ctgctggggt catggagctg ccaacaaagc ctggcacctt     1740

cgacctgggc ctggccacat ggagcccttc cttccagggg gaaacccacc gggctcaggc     1800

acgccgcagg gatgttggca ggcagctgcc tgagtacaag gctgtggtgg tgggcgccag     1860

tggcgtgggc aagagtgcgc tgaccatcca gctgaaccac cagtgcttcg tggaggacca     1920

cgaccccacc atccaggatt cctactggaa ggagttgacc ctggacagtg gggactgcat     1980

tctgaatgtg ctggacacag cagggcaggc catccatagg gccctgcgtg accagtgcct     2040

ggctgtctgt gatggtgtgc tgggcgtctt cgctctcgat gacccctcgt ctctgatcca     2100

gctgcagcag atatgggcca cctggggccc tcaccccgcc cagccccttg tcctcgtggg     2160

caacaagtgt gaccttgtga ccactgctgg agatgctcat gccgctgctg cagccctcgc     2220

acacagctgg ggggcccact tcgtggagac ctcggccaaa acacggcaag gcgtggagga     2280

ggccttttcc ctgctggtcc atgagatcca gagggtccag gaggccatgg cgaaggagcc     2340

catggcaagg tcctgtaggg agaagacccg gcaccagaag gccacctgcc actgtggctg     2400

ctctgtggcc tgaaggtctt ggccaagaaa tgtagacctt tccccaggcc agggtga        2457


<210>  109
<211>  826
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (81)..(83)
<223>  Putative translation start site

<400>  109
accgtcgggg acccccaagc tccgtcctcc gcttcctagc ctgctgccca cgtctcttcc       60

ctgagctgcc tgctggggtc atggagctgc caacaaagcc tggcaccttc gacctgggcc      120

tggccacatg gagcccttcc ttccaggggg aaacccaccg ggctcaggca cgccgcaggg      180

atgttggcag gcagctgcct gagtacaagg ctgtggtggt gggcgccagt ggcgtgggca      240

agagtgcgct gaccatccag ctgaaccacc agtgcttcgt ggaggaccac gaccccacca      300

tccaggattc ctactggaag gagttgaccc tggacagtgg ggactgcatt ctgaatgtgc      360

tggacacagc agggcaggcc atccataggg ccctgcgtga ccagtgcctg gctgtctgtg      420

atggtgtgct gggcgtcttc gctctcgatg acccctcgtc tctgatccag ctgcagcaga      480

tatgggccac ctggggccct caccccgccc agccccttgt cctcgtgggc aacaagtgtg      540

accttgtgac cactgctgga gatgctcatg ccgctgctgc agccctcgca cacagctggg      600

gggcccactt cgtggagacc tcggccaaaa cacggcaagg cgtggaggag gccttttccc      660

tgctggtcca tgagatccag agggtccagg aggccatggc gaaggagccc atggcaaggt      720

cctgtaggga gaagacccgg caccagaagg ccacctgcca ctgtggctgc tctgtggcct      780

gaaggtcttg gccaagaaat gtagaccttt ccccaggcca gggtga                     826


<210>  110
<211>  7979
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse tetracycline transactivator (M2rtTA) - vector

<400>  110
cgataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt       60

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc      120

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga      180

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc      240

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct      300

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg      360

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct      420

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc      480

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg      540

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcatcgata      600

ccgtcgacct cgagacctag aaaaacatgg agcaatcaca agtagcaata cagcagctac      660

caatgctgat tgtgcctggc tagaagcaca agaggaggag gaggtgggtt ttccagtcac      720

acctcaggta cctttaagac caatgactta caaggcagct gtagatctta gccacttttt      780

aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atatccttga      840

tctgtggatc taccacacac aaggctactt ccctgattgg cagaactaca caccagggcc      900

agggatcaga tatccactga cctttggatg gtgctacaag ctagtaccag ttgagcaaga      960

gaaggtagaa gaagccaatg aaggagagaa cacccgcttg ttacaccctg tgagcctgca     1020

tgggatggat gacccggaga gagaagtatt agagtggagg tttgacagcc gcctagcatt     1080

tcatcacatg gcccgagagc tgcatccgga ctgtactggg tctctctggt tagaccagat     1140

ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt     1200

gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc     1260

cctcagaccc ttttagtcag tgtggaaaat ctctagcagg gcccgtttaa acccgctgat     1320

cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt     1380

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat     1440

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg     1500

gggaggattg ggaagacaat agcaggcatg tgagcaaaag gccagcaaaa ggccaggaac     1560

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     1620

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     1680

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     1740

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     1800

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     1860

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     1920

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     1980

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt     2040

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     2100

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     2160

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     2220

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     2280

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     2340

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     2400

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     2460

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     2520

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     2580

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     2640

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     2700

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     2760

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     2820

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     2880

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     2940

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     3000

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     3060

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     3120

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     3180

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     3240

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     3300

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tcgacggatc gggagatctc     3360

ccgatcccct atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt     3420

atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta     3480

caacaaggca aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg     3540

cgctgcttcg cgatgtacgg gccagatata cgcgttgaca ttgattattg actagttatt     3600

aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat     3660

aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa     3720

taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg     3780

agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc     3840

cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct     3900

tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga     3960

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa     4020

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc     4080

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg     4140

aggtctatat aagcagcgcg ttttgcctgt actgggtctc tctggttaga ccagatctga     4200

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct     4260

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc     4320

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag     4380

cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg     4440

caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga     4500

aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg     4560

aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg     4620

caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct     4680

gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat     4740

cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca     4800

ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc     4860

aagcggccgc tgatcttcag acctggagga ggagatatga gggacaattg gagaagtgaa     4920

ttatataaat ataaagtagt aaaaattgaa ccattaggag tagcacccac caaggcaaag     4980

agaagagtgg tgcagagaga aaaaagagca gtgggaatag gagctttgtt ccttgggttc     5040

ttgggagcag caggaagcac tatgggcgca gcgtcaatga cgctgacggt acaggccaga     5100

caattattgt ctggtatagt gcagcagcag aacaatttgc tgagggctat tgaggcgcaa     5160

cagcatctgt tgcaactcac agtctggggc atcaagcagc tccaggcaag aatcctggct     5220

gtggaaagat acctaaagga tcaacagctc ctggggattt ggggttgctc tggaaaactc     5280

atttgcacca ctgctgtgcc ttggaatgct agttggagta ataaatctct ggaacagatt     5340

tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac aagcttaata     5400

cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga attattggaa     5460

ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct gtggtatata     5520

aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt tgctgtactt     5580

tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac ccacctccca     5640

accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga gagagacaga     5700

gacagatcca ttcgattagt gaacggatcg gcactgcgtg cgccaattct gcagacaaat     5760

ggcagtattc atccacaatt ttaaaagaaa aggggggatt ggggggtaca gtgcagggga     5820

aagaatagta gacataatag caacagacat acaaactaaa gaattacaaa aacaaattac     5880

aaaaattcaa aattttcggg tttattacag ggacagcaga gatccagttt ggttaattaa     5940

cccgtgtcgg ctccagatct ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc     6000

cctcctcacg gcgagcgctg ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc     6060

cgcccggacg ctcaggacag cggcccgctg ctcataagac tcggccttag aaccccagta     6120

tcagcagaag gacattttag gacgggactt gggtgactct agggcactgg ttttctttcc     6180

agagagcgga acaggcgagg aaaagtagtc ccttctcggc gattctgcgg agggatctcc     6240

gtggggcggt gaacgccgat gattatataa ggacgcgccg ggtgtggcac agctagttcc     6300

gtcgcagccg ggatttgggt cgcggttctt gtttgtggat cgctgtgatc gtcacttggt     6360

gagtagcggg ctgctgggct ggccggggct ttcgtggccg ccgggccgct cggtgggacg     6420

gaagcgtgtg gagagaccgc caagggctgt agtctgggtc cgcgagcaag gttgccctga     6480

actgggggtt ggggggagcg cagcaaaatg gcggctgttc ccgagtcttg aatggaagac     6540

gcttgtgagg cgggctgtga ggtcgttgaa acaaggtggg gggcatggtg ggcggcaaga     6600

acccaaggtc ttgaggcctt cgctaatgcg ggaaagctct tattcgggtg agatgggctg     6660

gggcaccatc tggggaccct gacgtgaagt ttgtcactga ctggagaact cggtttgtcg     6720

tctgttgcgg gggcggcagt tatggcggtg ccgttgggca gtgcacccgt acctttggga     6780

gcgcgcgccc tcgtcgtgtc gtgacgtcac ccgttctgtt ggcttataat gcagggtggg     6840

gccacctgcc ggtaggtgtg cggtaggctt ttctccgtcg caggacgcag ggttcgggcc     6900

tagggtaggc tctcctgaat cgacaggcgc cggacctctg gtgaggggag ggataagtga     6960

ggcgtcagtt tctttggtcg gttttatgta cctatcttct taagtagctg aagctccggt     7020

tttgaactat gcgctcgggg ttggcgagtg tgttttgtga agttttttag gcaccttttg     7080

aaatgtaatc atttgggtca atatgtaatt ttcagtgtta gactagtaaa ttgtccgcta     7140

aattctggcc gtttttggct tttttgttag acgaagcttg ggcccgggaa ttaattcacc     7200

atgtctagac tggacaagag caaagtcata aacggcgctc tggaattact caatggagtc     7260

ggtatcgaag gcctgacgac aaggaaactc gctcaaaagc tgggagttga gcagcctacc     7320

ctgtactggc acgtgaagaa caagcgggcc ctgctcgatg ccctgccaat cgagatgctg     7380

gacaggcatc atacccactt ctgccccctg gaaggcgagt catggcaaga ctttctgcgg     7440

aacaacgcca agtcattccg ctgtgctctc ctctcacatc gcgacggggc taaagtgcat     7500

ctcggcaccc gcccaacaga gaaacagtac gaaaccctgg aaaatcagct cgcgttcctg     7560

tgtcagcaag gcttctccct ggagaacgca ctgtacgctc tgtccgccgt gggccacttt     7620

acactgggct gcgtattgga ggaacaggag catcaagtag caaaagagga aagagagaca     7680

cctaccaccg attctatgcc cccacttctg agacaagcaa ttgagctgtt cgaccggcag     7740

ggagccgaac ctgccttcct tttcggcctg gaactaatca tatgtggcct ggagaaacag     7800

ctaaagtgcg aaagcggcgg gccggccgac gcccttgacg attttgactt agacatgctc     7860

ccagccgatg cccttgacga ctttgacctt gatatgctgc ctgctgacgc tcttgacgat     7920

tttgaccttg acatgctccc cgggtaacta agtaaggatc aattcgatat caagcttat      7979


<210>  111
<211>  1201
<212>  DNA
<213>  Homo sapiens

<400>  111
aatattagag tctcaacccc caataaatat aggactggag atgtctgagg ctcattctgc       60

cctcgagccc accgggaacg aaagagaagc tctatctccc ctccaggagc ccagctatga      120

actccttctc cacaagcgcc ttcggtccag ttgccttctc cctggggctg ctcctggtgt      180

tgcctgctgc cttccctgcc ccagtacccc caggagaaga ttccaaagat gtagccgccc      240

cacacagaca gccactcacc tcttcagaac gaattgacaa acaaattcgg tacatcctcg      300

acggcatctc agccctgaga aaggagacat gtaacaagag taacatgtgt gaaagcagca      360

aagaggcact ggcagaaaac aacctgaacc ttccaaagat ggctgaaaaa gatggatgct      420

tccaatctgg attcaatgag gagacttgcc tggtgaaaat catcactggt cttttggagt      480

ttgaggtata cctagagtac ctccagaaca gatttgagag tagtgaggaa caagccagag      540

ctgtgcagat gagtacaaaa gtcctgatcc agttcctgca gaaaaaggca aagaatctag      600

atgcaataac cacccctgac ccaaccacaa atgccagcct gctgacgaag ctgcaggcac      660

agaaccagtg gctgcaggac atgacaactc atctcattct gcgcagcttt aaggagttcc      720

tgcagtccag cctgagggct cttcggcaaa tgtagcatgg gcacctcaga ttgttgttgt      780

taatgggcat tccttcttct ggtcagaaac ctgtccactg ggcacagaac ttatgttgtt      840

ctctatggag aactaaaagt atgagcgtta ggacactatt ttaattattt ttaatttatt      900

aatatttaaa tatgtgaagc tgagttaatt tatgtaagtc atatttatat ttttaagaag      960

taccacttga aacattttat gtattagttt tgaaataata atggaaagtg gctatgcagt     1020

ttgaatatcc tttgtttcag agccagatca tttcttggaa agtgtaggct tacctcaaat     1080

aaatggctaa cttatacata tttttaaaga aatatttata ttgtatttat ataatgtata     1140

aatggttttt ataccaataa atggcatttt aaaaaattca gcaaaaaaaa aaaaaaaaaa     1200

a                                                                     1201


<210>  112
<211>  1902
<212>  DNA
<213>  Homo sapiens

<400>  112
atgaccgaag aagcatgccg aacacggagt cagaaacgag cgcttgaacg ggacccaaca       60

gaggacgatg tggagagcaa gaaaataaaa atggagagag gattgttggc ttcagattta      120

aacactgacg gagacatgag ggtgacacct gagccgggag caggtccaac ccaaggattg      180

ctgagggcaa cagaggccac ggccatggcc atgggcagag gcgaagggct ggtgggcgat      240

gggcccgtgg acatgcgcac ctcacacagt gacatgaagt ccgagaggag acccccctca      300

cctgacgtga ttgtgctctc cgacaacgag cagccctcga gcccgagagt gaatgggctg      360

accacggtgg ccttgaagga gactagcacc gaggccctca tgaaaagcag tcctgaagaa      420

cgagaaagga tgatcaagca gctgaaggaa gaattgaggt tagaagaagc aaaactcgtg      480

ttgttgaaaa agttgcggca gagtcaaata caaaaggaag ccaccgccca gaagcccaca      540

ggttctgttg ggagcaccgt gaccacccct cccccgcttg ttcggggcac tcagaacatt      600

cctgctggca agccatcact ccagacctct tcagctcgga tgcccggcag tgtcataccc      660

ccgcccctgg tccgaggtgg gcagcaggcg tcctcgaagc tggggccaca ggcgagctca      720

caggtcgtca tgcccccact cgtcaggggg gctcagcaaa tccacagcat taggcaacat      780

tccagcacag ggccaccgcc cctcctcctg gccccccggg cgtcggtgcc cagtgtgcag      840

attcagggac agaggatcat ccagcagggc ctcatccgcg tcgccaatgt tcccaacacc      900

agcctgctcg tcaacatccc acagcccacc ccagcatcac tgaaggggac aacagccacc      960

tccgctcagg ccaactccac ccccactagt gtggcctctg tggtcacctc tgccgagtct     1020

ccagcaagcc gacaggcggc cgccaagctg gcgctgcgca aacagctgga gaagacgcta     1080

ctcgagatcc ccccacccaa gcccccagcc ccagagatga acttcctgcc cagcgccgcc     1140

aacaacgagt tcatctacct ggtcggcctg gaggaggtgg tgcagaacct actggagaca     1200

caaggcagga tgtcggccgc cactgtgctg tcccgggagc cctacatgtg tgcacagtgc     1260

aagacggact tcacgtgccg ctggcgggag gagaagagcg gcgccatcat gtgtgagaac     1320

tgcatgacaa ccaaccagaa gaaggcgctc aaggtggagc acaccagccg gctgaaggcc     1380

gcctttgtga aggcgctgca gcaggaacag gagattgagc agcggctcct gcagcagggc     1440

acggcccctg cacaggccaa ggccgagccc accgctgccc cacaccccgt gctgaagcag     1500

gtcataaaac cccggcgtaa gttggcgttc cgctcaggag aggcccgcga ctggagtaac     1560

ggggctgtgc tacaggcctc cagccagctg tcccggggtt cggccacgac gccccgaggt     1620

gtcctgcaca cgttcagtcc gtcacccaaa ctgcagaact cagcctcggc cacagccctg     1680

gtcagcagga ccggcagaca ttctgagaga accgtgagcg ccggcaaggg cagcgccacc     1740

tccaactgga agaagacgcc cctcagcaca ggcgggaccc ttgcgtttgt cagcccaagc     1800

ctggcggtgc acaagagctc ctcggccgtg gaccgccagc gagagtacct cctggacatg     1860

atcccacccc gctccatccc ccagtcagcc acgtggaaat ag                        1902


<210>  113
<211>  123
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(123)
<223>  P66 alpha coiled-coil domain coding sequence

<400>  113
cctgaagaac gagaaaggat gatcaagcag ctgaaggaag aattgaggtt agaagaagca       60

aaactcgtgt tgttgaaaaa gttgcggcag agtcaaatac aaaaggaagc caccgcccag      120

aag                                                                    123


<210>  114
<211>  41
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  P66 alpha coiled-coil domain

<400>  114

Pro Glu Glu Arg Glu Arg Met Ile Lys Gln Leu Lys Glu Glu Leu Arg 
1               5                   10                  15      


Leu Glu Glu Ala Lys Leu Val Leu Leu Lys Lys Leu Arg Gln Ser Gln 
            20                  25                  30          


Ile Gln Lys Glu Ala Thr Ala Gln Lys 
        35                  40      


<210>  115
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  115
aaaaaaaccg gtcctgaaga acgagaaagg                                        30


<210>  116
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  116
aaaaaactta agcttctggg cggtggc                                           27


<210>  117
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  118
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Glu Arg Cys Pro Ser Leu Gly Val Thr Leu Tyr Ala Leu Val Val 
1               5                   10                  15      


Val Leu Gly Leu Arg Ala Thr Pro Ala Gly Gly Gln His Tyr Leu His 
            20                  25                  30          


Ile Arg Pro Ala Pro Ser Asp Asn Leu Pro Leu Val Asp Leu Ile Glu 
        35                  40                  45              


His Pro Asp Pro Ile Phe Asp Pro Lys Glu Lys Asp Leu Asn Glu Thr 
    50                  55                  60                  


Leu Leu Arg Ser Leu Leu Gly Gly His Tyr Asp Pro Gly Phe Met Ala 
65                  70                  75                  80  


Thr Ser Pro Pro Glu Asp Arg Pro Gly Gly Gly Gly Gly Ala Ala Gly 
                85                  90                  95      


Gly Ala Glu Asp Leu Ala Glu Leu Asp Gln Leu Leu Arg Gln Arg Pro 
            100                 105                 110         


Ser Gly Ala Met Pro Ser Glu Ile Lys Gly Leu Glu Phe Ser Glu Gly 
        115                 120                 125             


Leu Ala Gln Gly Lys Lys Gln Arg Leu Ser Lys Lys Leu Arg Arg Lys 
    130                 135                 140                 


Leu Gln Met Trp Leu Trp Ser Gln Thr Phe Cys Pro Val Leu Tyr Ala 
145                 150                 155                 160 


Trp Asn Asp Leu Gly Ser Arg Phe Trp Pro Arg Tyr Val Lys Val Gly 
                165                 170                 175     


Ser Cys Phe Ser Lys Arg Ser Cys Ser Val Pro Glu Gly Met Val Cys 
            180                 185                 190         


Lys Pro Ser Lys Ser Val His Leu Thr Val Leu Arg Trp Arg Cys Gln 
        195                 200                 205             


Arg Arg Gly Gly Gln Arg Cys Gly Trp Ile Pro Ile Gln Tyr Pro Ile 
    210                 215                 220                 


Ile Ser Glu Cys Lys Cys Ser Cys 
225                 230         


<210>  119
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Lys Val Leu Ala Ala Val His Ser Pro Gly Gly Ala Val Pro Gln 
1               5                   10                  15      


Gln Pro Gly Gln Ala Met Trp Pro Gln Arg Asp Gly Leu Pro Ala Leu 
            20                  25                  30          


Pro Arg Gln Arg His Gly Glu Gly Gln Ala Gly Gly Ala Val Pro His 
        35                  40                  45              


Ser Arg Val Pro Trp His Leu Pro Gly Gln His His Pro Gly Pro Glu 
    50                  55                  60                  


Asp Pro Gln Pro Gln Cys Pro Gln Pro Pro Gln Gln Ala Gln Arg His 
65                  70                  75                  80  


Arg Arg His Pro Ala Arg Pro Pro 
                85              


<210>  120
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  121
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp 
    290                 295                 300                 


Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro 
305                 310                 315                 320 


Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr 
                325                 330                 335     


Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe 
            340                 345                 350         


Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp 
        355                 360                 365             


Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro 
    370                 375                 380                 


Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala 
385                 390                 395                 400 


Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly 
                405                 410                 415     


Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser 
            420                 425                 430         


Thr 
    


<210>  122
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  123
<211>  2175
<212>  DNA
<213>  Homo sapiens

<400>  123
agtacagtat aaaacttcac agtgccaata ccatgaagag gagctcagac agctcttacc       60

acatgataca agagccggct ggtggaagag tggggaccag aaagagaatt tgctgaagag      120

gagaaggaaa aaaaaaacac caaaaaaaaa aataaaaaaa tccacacaca caaaaaaacc      180

tgcgcgtgag gggggaggaa aagcagggcc ttttaaaaag gcaatcacaa caacttttgc      240

tgccaggatg cccttgcttt ggctgagagg atttctgttg gcaagttgct ggattatagt      300

gaggagttcc cccaccccag gatccgaggg gcacagcgcg gcccccgact gtccgtcctg      360

tgcgctggcc gccctcccaa aggatgtacc caactctcag ccagagatgg tggaggccgt      420

caagaagcac attttaaaca tgctgcactt gaagaagaga cccgatgtca cccagccggt      480

acccaaggcg gcgcttctga acgcgatcag aaagcttcat gtgggcaaag tcggggagaa      540

cgggtatgtg gagatagagg atgacattgg aaggagggca gaaatgaatg aacttatgga      600

gcagacctcg gagatcatca cgtttgccga gtcaggaaca gccaggaaga cgctgcactt      660

cgagatttcc aaggaaggca gtgacctgtc agtggtggag cgtgcagaag tctggctctt      720

cctaaaagtc cccaaggcca acaggaccag gaccaaagtc accatccgcc tcttccagca      780

gcagaagcac ccgcagggca gcttggacac aggggaagag gccgaggaag tgggcttaaa      840

gggggagagg agtgaactgt tgctctctga aaaagtagta gacgctcgga agagcacctg      900

gcatgtcttc cctgtctcca gcagcatcca gcggttgctg gaccagggca agagctccct      960

ggacgttcgg attgcctgtg agcagtgcca ggagagtggc gccagcttgg ttctcctggg     1020

caagaagaag aagaaagaag aggaggggga agggaaaaag aagggcggag gtgaaggtgg     1080

ggcaggagca gatgaggaaa aggagcagtc gcacagacct ttcctcatgc tgcaggcccg     1140

gcagtctgaa gaccaccctc atcgccggcg tcggcggggc ttggagtgtg atggcaaggt     1200

caacatctgc tgtaagaaac agttctttgt cagtttcaag gacatcggct ggaatgactg     1260

gatcattgct ccctctggct atcatgccaa ctactgcgag ggtgagtgcc cgagccatat     1320

agcaggcacg tccgggtcct cactgtcctt ccactcaaca gtcatcaacc actaccgcat     1380

gcggggccat agcccctttg ccaacctcaa atcgtgctgt gtgcccacca agctgagacc     1440

catgtccatg ttgtactatg atgatggtca aaacatcatc aaaaaggaca ttcagaacat     1500

gatcgtggag gagtgtgggt gctcatagag ttgcccagcc cagggggaaa gggagcaaga     1560

gttgtccaga gaagacagtg gcaaaatgaa gaaattttta aggtttctga gttaaccaga     1620

aaaatagaaa ttaaaaacaa aacaaaaaaa aaaacaaaaa aaaacaaaag taaattaaaa     1680

acaaaacctg atgaaacaga tgaaggaaga tgtggaaaaa atccttagcc agggctcaga     1740

gatgaagcag tgaaagagac aggaattggg agggaaaggg agaatggtgt accctttatt     1800

tcttctgaaa tcacactgat gacatcagtt gtttaaacgg ggtattgtcc tttcccccct     1860

tgaggttccc ttgtgagcct tgaatcaacc aatctagtct gcagtagtgt ggactagaac     1920

aacccaaata gcatctagaa agccatgagt ttgaaagggc ccatcacagg cactttccta     1980

cccaattacc caggtcataa ggtatgtctg tgtgacactt atctctgtgt atatcagcat     2040

acacacacac acacacacac acacacacac acacaggcat ttccacacat tacatatata     2100

cacatactgg taaaagaaca atcgtgtgca ggtggtcaca cttccttttt ctgtaccact     2160

tttgcaacaa aacaa                                                      2175


