                         SEQUENCE LISTING

<110>  SISENE SAS
       Pakradouni, Jihane
       Minet, Norbert
 
<120>  Use of fragments of NOV/CCN3 protein for treating pathologies

<130>  BR71314/RIM

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide derived from NOV protein

<400>  1

Ala Tyr Arg Pro Glu Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser 
1               5                   10                  15      


Val Asn Cys Ile Glu Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser 
            20                  25                  30          


Cys Gly Met Gly Phe Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys 
        35                  40                  45              


Glu Met Leu Lys Gln Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln 
    50                  55                  60                  


Glu Pro Glu Gln Pro Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr 
65                  70                  75                  80  


Lys Lys Ser Leu Lys Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser 
                85                  90                  95      


Leu His Thr Tyr Lys Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg 
            100                 105                 110         


Cys Cys Thr Pro His Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys 
        115                 120                 125             


Ser Pro Gly Gln Ile Val Lys Lys Pro Val Met Val Ile Gly Thr Cys 
    130                 135                 140                 


Thr Cys His Thr Asn Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu 
145                 150                 155                 160 


Leu Glu Leu Lys Thr Thr Arg Gly Lys Met 
                165                 170 


<210>  2
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide derived from NOV protein

<400>  2

Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu Gln Thr Thr Glu 
1               5                   10                  15      


Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe Ser Thr Arg Val 
            20                  25                  30          


Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln Thr Arg Leu Cys 
        35                  40                  45              


Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro Thr Asp Lys Lys 
    50                  55                  60                  


Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys Ala Ile His Leu 
65                  70                  75                  80  


Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys Pro Arg Phe Cys 
                85                  90                  95      


Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His Asn Thr Lys Thr 
            100                 105                 110         


Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile Val Lys Lys Pro 
        115                 120                 125             


Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn Cys Pro Lys Asn 
    130                 135                 140                 


Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr Thr Arg Gly Lys 
145                 150                 155                 160 


Met 
    


<210>  3
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Ser Val Gln Ser Thr Ser Phe Cys Leu Arg Lys Gln Cys Leu 
1               5                   10                  15      


Cys Leu Thr Phe Leu Leu Leu His Leu Leu Gly Gln Val Ala Ala Thr 
            20                  25                  30          


Gln Arg Cys Pro Pro Gln Cys Pro Gly Arg Cys Pro Ala Thr Pro Pro 
        35                  40                  45              


Thr Cys Ala Pro Gly Val Arg Ala Val Leu Asp Gly Cys Ser Cys Cys 
    50                  55                  60                  


Leu Val Cys Ala Arg Gln Arg Gly Glu Ser Cys Ser Asp Leu Glu Pro 
65                  70                  75                  80  


Cys Asp Glu Ser Ser Gly Leu Tyr Cys Asp Arg Ser Ala Asp Pro Ser 
                85                  90                  95      


Asn Gln Thr Gly Ile Cys Thr Ala Val Glu Gly Asp Asn Cys Val Phe 
            100                 105                 110         


Asp Gly Val Ile Tyr Arg Ser Gly Glu Lys Phe Gln Pro Ser Cys Lys 
        115                 120                 125             


Phe Gln Cys Thr Cys Arg Asp Gly Gln Ile Gly Cys Val Pro Arg Cys 
    130                 135                 140                 


Gln Leu Asp Val Leu Leu Pro Glu Pro Asn Cys Pro Ala Pro Arg Lys 
145                 150                 155                 160 


Val Glu Val Pro Gly Glu Cys Cys Glu Lys Trp Ile Cys Gly Pro Asp 
                165                 170                 175     


Glu Glu Asp Ser Leu Gly Gly Leu Thr Leu Ala Ala Tyr Arg Pro Glu 
            180                 185                 190         


Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu 
        195                 200                 205             


Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe 
    210                 215                 220                 


Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln 
225                 230                 235                 240 


Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro 
                245                 250                 255     


Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys 
            260                 265                 270         


Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys 
        275                 280                 285             


Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His 
    290                 295                 300                 


Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile 
305                 310                 315                 320 


Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn 
                325                 330                 335     


Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr 
            340                 345                 350         


Thr Arg Gly Lys Met 
        355         


<210>  4
<211>  169
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  4

Tyr Arg Pro Glu Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val 
1               5                   10                  15      


Asn Cys Ile Glu Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys 
            20                  25                  30          


Gly Met Gly Phe Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu 
        35                  40                  45              


Met Leu Lys Gln Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu 
    50                  55                  60                  


Pro Glu Gln Pro Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys 
65                  70                  75                  80  


Lys Ser Leu Lys Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu 
                85                  90                  95      


His Thr Tyr Lys Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys 
            100                 105                 110         


Cys Thr Pro His Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser 
        115                 120                 125             


Pro Gly Gln Ile Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr 
    130                 135                 140                 


Cys His Thr Asn Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu 
145                 150                 155                 160 


Glu Leu Lys Thr Thr Arg Gly Lys Met 
                165                 


<210>  5
<211>  168
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  5

Arg Pro Glu Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn 
1               5                   10                  15      


Cys Ile Glu Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly 
            20                  25                  30          


Met Gly Phe Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met 
        35                  40                  45              


Leu Lys Gln Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro 
    50                  55                  60                  


Glu Gln Pro Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys 
65                  70                  75                  80  


Ser Leu Lys Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His 
                85                  90                  95      


Thr Tyr Lys Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys 
            100                 105                 110         


Thr Pro His Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro 
        115                 120                 125             


Gly Gln Ile Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys 
    130                 135                 140                 


His Thr Asn Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu 
145                 150                 155                 160 


Leu Lys Thr Thr Arg Gly Lys Met 
                165             


<210>  6
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  6

Pro Glu Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys 
1               5                   10                  15      


Ile Glu Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met 
            20                  25                  30          


Gly Phe Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu 
        35                  40                  45              


Lys Gln Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu 
    50                  55                  60                  


Gln Pro Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser 
65                  70                  75                  80  


Leu Lys Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr 
                85                  90                  95      


Tyr Lys Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr 
            100                 105                 110         


Pro His Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly 
        115                 120                 125             


Gln Ile Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His 
    130                 135                 140                 


Thr Asn Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu 
145                 150                 155                 160 


Lys Thr Thr Arg Gly Lys Met 
                165         


<210>  7
<211>  166
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  7

Glu Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile 
1               5                   10                  15      


Glu Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly 
            20                  25                  30          


Phe Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys 
        35                  40                  45              


Gln Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln 
    50                  55                  60                  


Pro Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu 
65                  70                  75                  80  


Lys Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr 
                85                  90                  95      


Lys Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro 
            100                 105                 110         


His Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln 
        115                 120                 125             


Ile Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr 
    130                 135                 140                 


Asn Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys 
145                 150                 155                 160 


Thr Thr Arg Gly Lys Met 
                165     


<210>  8
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  8

Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu 
1               5                   10                  15      


Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe 
            20                  25                  30          


Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln 
        35                  40                  45              


Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro 
    50                  55                  60                  


Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys 
65                  70                  75                  80  


Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys 
                85                  90                  95      


Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His 
            100                 105                 110         


Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile 
        115                 120                 125             


Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn 
    130                 135                 140                 


Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr 
145                 150                 155                 160 


Thr Arg Gly Lys Met 
                165 


<210>  9
<211>  164
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  9

Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu Gln 
1               5                   10                  15      


Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe Ser 
            20                  25                  30          


Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln Thr 
        35                  40                  45              


Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro Thr 
    50                  55                  60                  


Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys Ala 
65                  70                  75                  80  


Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys Pro 
                85                  90                  95      


Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His Asn 
            100                 105                 110         


Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile Val 
        115                 120                 125             


Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn Cys 
    130                 135                 140                 


Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr Thr 
145                 150                 155                 160 


Arg Gly Lys Met 
                


<210>  10
<211>  163
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  10

Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu Gln Thr 
1               5                   10                  15      


Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe Ser Thr 
            20                  25                  30          


Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln Thr Arg 
        35                  40                  45              


Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro Thr Asp 
    50                  55                  60                  


Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys Ala Ile 
65                  70                  75                  80  


His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys Pro Arg 
                85                  90                  95      


Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His Asn Thr 
            100                 105                 110         


Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile Val Lys 
        115                 120                 125             


Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn Cys Pro 
    130                 135                 140                 


Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr Thr Arg 
145                 150                 155                 160 


Gly Lys Met 
            


<210>  11
<211>  162
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  11

Leu Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu Gln Thr Thr 
1               5                   10                  15      


Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe Ser Thr Arg 
            20                  25                  30          


Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln Thr Arg Leu 
        35                  40                  45              


Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro Thr Asp Lys 
    50                  55                  60                  


Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys Ala Ile His 
65                  70                  75                  80  


Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys Pro Arg Phe 
                85                  90                  95      


Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His Asn Thr Lys 
            100                 105                 110         


Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile Val Lys Lys 
        115                 120                 125             


Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn Cys Pro Lys 
    130                 135                 140                 


Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr Thr Arg Gly 
145                 150                 155                 160 


Lys Met 
        


<210>  12
<211>  160
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  12

Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu Gln Thr Thr Glu Trp 
1               5                   10                  15      


Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe Ser Thr Arg Val Thr 
            20                  25                  30          


Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln Thr Arg Leu Cys Met 
        35                  40                  45              


Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro Thr Asp Lys Lys Gly 
    50                  55                  60                  


Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys Ala Ile His Leu Gln 
65                  70                  75                  80  


Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys Pro Arg Phe Cys Gly 
                85                  90                  95      


Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His Asn Thr Lys Thr Ile 
            100                 105                 110         


Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile Val Lys Lys Pro Val 
        115                 120                 125             


Met Val Ile Gly Thr Cys Thr Cys His Thr Asn Cys Pro Lys Asn Asn 
    130                 135                 140                 


Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr Thr Arg Gly Lys Met 
145                 150                 155                 160 


<210>  13
<211>  159
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  13

Val Ser Asp Ser Ser Val Asn Cys Ile Glu Gln Thr Thr Glu Trp Thr 
1               5                   10                  15      


Ala Cys Ser Lys Ser Cys Gly Met Gly Phe Ser Thr Arg Val Thr Asn 
            20                  25                  30          


Arg Asn Arg Gln Cys Glu Met Leu Lys Gln Thr Arg Leu Cys Met Val 
        35                  40                  45              


Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro Thr Asp Lys Lys Gly Lys 
    50                  55                  60                  


Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys Ala Ile His Leu Gln Phe 
65                  70                  75                  80  


Lys Asn Cys Thr Ser Leu His Thr Tyr Lys Pro Arg Phe Cys Gly Val 
                85                  90                  95      


Cys Ser Asp Gly Arg Cys Cys Thr Pro His Asn Thr Lys Thr Ile Gln 
            100                 105                 110         


Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile Val Lys Lys Pro Val Met 
        115                 120                 125             


Val Ile Gly Thr Cys Thr Cys His Thr Asn Cys Pro Lys Asn Asn Glu 
    130                 135                 140                 


Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr Thr Arg Gly Lys Met 
145                 150                 155                 


<210>  14
<211>  158
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide derived from NOV protein

<400>  14

Ser Asp Ser Ser Val Asn Cys Ile Glu Gln Thr Thr Glu Trp Thr Ala 
1               5                   10                  15      


Cys Ser Lys Ser Cys Gly Met Gly Phe Ser Thr Arg Val Thr Asn Arg 
            20                  25                  30          


Asn Arg Gln Cys Glu Met Leu Lys Gln Thr Arg Leu Cys Met Val Arg 
        35                  40                  45              


Pro Cys Glu Gln Glu Pro Glu Gln Pro Thr Asp Lys Lys Gly Lys Lys 
    50                  55                  60                  


Cys Leu Arg Thr Lys Lys Ser Leu Lys Ala Ile His Leu Gln Phe Lys 
65                  70                  75                  80  


Asn Cys Thr Ser Leu His Thr Tyr Lys Pro Arg Phe Cys Gly Val Cys 
                85                  90                  95      


Ser Asp Gly Arg Cys Cys Thr Pro His Asn Thr Lys Thr Ile Gln Ala 
            100                 105                 110         


Glu Phe Gln Cys Ser Pro Gly Gln Ile Val Lys Lys Pro Val Met Val 
        115                 120                 125             


Ile Gly Thr Cys Thr Cys His Thr Asn Cys Pro Lys Asn Asn Glu Ala 
    130                 135                 140                 


Phe Leu Gln Glu Leu Glu Leu Lys Thr Thr Arg Gly Lys Met 
145                 150                 155             


<210>  15
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid coding SEQ ID NO : 1

<400>  15
gcttacaggc cagaagccac cctaggagta gaagtctctg actcaagtgt caactgcatt       60

gaacagacca cagagtggac agcatgctcc aagagctgtg gtatggggtt ctccacccgg      120

gtcaccaata ggaaccgtca atgtgagatg ctgaaacaga ctcggctctg catggtgcgg      180

ccctgtgaac aagagccaga gcagccaaca gataagaaag gaaaaaagtg tctccgcacc      240

aagaagtcac tcaaagccat ccacctgcag ttcaagaact gcaccagcct gcacacctac      300

aagcccaggt tctgtggggt ctgcagtgat ggccgctgct gcactcccca caataccaaa      360

accatccagg cagagtttca gtgctcccca gggcaaatag tcaagaagcc agtgatggtc      420

attgggacct gcacctgtca caccaactgt cctaagaaca atgaggcctt cctccaggag      480

ctggagctga agactaccag agggaaaatg                                       510


<210>  16
<211>  486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 2

<400>  16
gtagaagtct ctgactcaag tgtcaactgc attgaacaga ccacagagtg gacagcatgc       60

tccaagagct gtggtatggg gttctccacc cgggtcacca ataggaaccg tcaatgtgag      120

atgctgaaac agactcggct ctgcatggtg cggccctgtg aacaagagcc agagcagcca      180

acagataaga aaggaaaaaa gtgtctccgc accaagaagt cactcaaagc catccacctg      240

cagttcaaga actgcaccag cctgcacacc tacaagccca ggttctgtgg ggtctgcagt      300

gatggccgct gctgcactcc ccacaatacc aaaaccatcc aggcagagtt tcagtgctcc      360

ccagggcaaa tagtcaagaa gccagtgatg gtcattggga cctgcacctg tcacaccaac      420

tgtcctaaga acaatgaggc cttcctccag gagctggagc tgaagactac cagagggaaa      480

atgtaa                                                                 486


<210>  17
<211>  507
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 4

<400>  17
tacaggccag aagccaccct aggagtagaa gtctctgact caagtgtcaa ctgcattgaa       60

cagaccacag agtggacagc atgctccaag agctgtggta tggggttctc cacccgggtc      120

accaatagga accgtcaatg tgagatgctg aaacagactc ggctctgcat ggtgcggccc      180

tgtgaacaag agccagagca gccaacagat aagaaaggaa aaaagtgtct ccgcaccaag      240

aagtcactca aagccatcca cctgcagttc aagaactgca ccagcctgca cacctacaag      300

cccaggttct gtggggtctg cagtgatggc cgctgctgca ctccccacaa taccaaaacc      360

atccaggcag agtttcagtg ctccccaggg caaatagtca agaagccagt gatggtcatt      420

gggacctgca cctgtcacac caactgtcct aagaacaatg aggccttcct ccaggagctg      480

gagctgaaga ctaccagagg gaaaatg                                          507


<210>  18
<211>  504
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 5

<400>  18
aggccagaag ccaccctagg agtagaagtc tctgactcaa gtgtcaactg cattgaacag       60

accacagagt ggacagcatg ctccaagagc tgtggtatgg ggttctccac ccgggtcacc      120

aataggaacc gtcaatgtga gatgctgaaa cagactcggc tctgcatggt gcggccctgt      180

gaacaagagc cagagcagcc aacagataag aaaggaaaaa agtgtctccg caccaagaag      240

tcactcaaag ccatccacct gcagttcaag aactgcacca gcctgcacac ctacaagccc      300

aggttctgtg gggtctgcag tgatggccgc tgctgcactc cccacaatac caaaaccatc      360

caggcagagt ttcagtgctc cccagggcaa atagtcaaga agccagtgat ggtcattggg      420

acctgcacct gtcacaccaa ctgtcctaag aacaatgagg ccttcctcca ggagctggag      480

ctgaagacta ccagagggaa aatg                                             504


<210>  19
<211>  501
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 6

<400>  19
ccagaagcca ccctaggagt agaagtctct gactcaagtg tcaactgcat tgaacagacc       60

acagagtgga cagcatgctc caagagctgt ggtatggggt tctccacccg ggtcaccaat      120

aggaaccgtc aatgtgagat gctgaaacag actcggctct gcatggtgcg gccctgtgaa      180

caagagccag agcagccaac agataagaaa ggaaaaaagt gtctccgcac caagaagtca      240

ctcaaagcca tccacctgca gttcaagaac tgcaccagcc tgcacaccta caagcccagg      300

ttctgtgggg tctgcagtga tggccgctgc tgcactcccc acaataccaa aaccatccag      360

gcagagtttc agtgctcccc agggcaaata gtcaagaagc cagtgatggt cattgggacc      420

tgcacctgtc acaccaactg tcctaagaac aatgaggcct tcctccagga gctggagctg      480

aagactacca gagggaaaat g                                                501


<210>  20
<211>  498
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 7

<400>  20
gaagccaccc taggagtaga agtctctgac tcaagtgtca actgcattga acagaccaca       60

gagtggacag catgctccaa gagctgtggt atggggttct ccacccgggt caccaatagg      120

aaccgtcaat gtgagatgct gaaacagact cggctctgca tggtgcggcc ctgtgaacaa      180

gagccagagc agccaacaga taagaaagga aaaaagtgtc tccgcaccaa gaagtcactc      240

aaagccatcc acctgcagtt caagaactgc accagcctgc acacctacaa gcccaggttc      300

tgtggggtct gcagtgatgg ccgctgctgc actccccaca ataccaaaac catccaggca      360

gagtttcagt gctccccagg gcaaatagtc aagaagccag tgatggtcat tgggacctgc      420

acctgtcaca ccaactgtcc taagaacaat gaggccttcc tccaggagct ggagctgaag      480

actaccagag ggaaaatg                                                    498


<210>  21
<211>  495
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 8

<400>  21
gccaccctag gagtagaagt ctctgactca agtgtcaact gcattgaaca gaccacagag       60

tggacagcat gctccaagag ctgtggtatg gggttctcca cccgggtcac caataggaac      120

cgtcaatgtg agatgctgaa acagactcgg ctctgcatgg tgcggccctg tgaacaagag      180

ccagagcagc caacagataa gaaaggaaaa aagtgtctcc gcaccaagaa gtcactcaaa      240

gccatccacc tgcagttcaa gaactgcacc agcctgcaca cctacaagcc caggttctgt      300

ggggtctgca gtgatggccg ctgctgcact ccccacaata ccaaaaccat ccaggcagag      360

tttcagtgct ccccagggca aatagtcaag aagccagtga tggtcattgg gacctgcacc      420

tgtcacacca actgtcctaa gaacaatgag gccttcctcc aggagctgga gctgaagact      480

accagaggga aaatg                                                       495


<210>  22
<211>  492
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 9

<400>  22
accctaggag tagaagtctc tgactcaagt gtcaactgca ttgaacagac cacagagtgg       60

acagcatgct ccaagagctg tggtatgggg ttctccaccc gggtcaccaa taggaaccgt      120

caatgtgaga tgctgaaaca gactcggctc tgcatggtgc ggccctgtga acaagagcca      180

gagcagccaa cagataagaa aggaaaaaag tgtctccgca ccaagaagtc actcaaagcc      240

atccacctgc agttcaagaa ctgcaccagc ctgcacacct acaagcccag gttctgtggg      300

gtctgcagtg atggccgctg ctgcactccc cacaatacca aaaccatcca ggcagagttt      360

cagtgctccc cagggcaaat agtcaagaag ccagtgatgg tcattgggac ctgcacctgt      420

cacaccaact gtcctaagaa caatgaggcc ttcctccagg agctggagct gaagactacc      480

agagggaaaa tg                                                          492


<210>  23
<211>  489
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 10

<400>  23
ctaggagtag aagtctctga ctcaagtgtc aactgcattg aacagaccac agagtggaca       60

gcatgctcca agagctgtgg tatggggttc tccacccggg tcaccaatag gaaccgtcaa      120

tgtgagatgc tgaaacagac tcggctctgc atggtgcggc cctgtgaaca agagccagag      180

cagccaacag ataagaaagg aaaaaagtgt ctccgcacca agaagtcact caaagccatc      240

cacctgcagt tcaagaactg caccagcctg cacacctaca agcccaggtt ctgtggggtc      300

tgcagtgatg gccgctgctg cactccccac aataccaaaa ccatccaggc agagtttcag      360

tgctccccag ggcaaatagt caagaagcca gtgatggtca ttgggacctg cacctgtcac      420

accaactgtc ctaagaacaa tgaggccttc ctccaggagc tggagctgaa gactaccaga      480

gggaaaatg                                                              489


<210>  24
<211>  486
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 11

<400>  24
ggagtagaag tctctgactc aagtgtcaac tgcattgaac agaccacaga gtggacagca       60

tgctccaaga gctgtggtat ggggttctcc acccgggtca ccaataggaa ccgtcaatgt      120

gagatgctga aacagactcg gctctgcatg gtgcggccct gtgaacaaga gccagagcag      180

ccaacagata agaaaggaaa aaagtgtctc cgcaccaaga agtcactcaa agccatccac      240

ctgcagttca agaactgcac cagcctgcac acctacaagc ccaggttctg tggggtctgc      300

agtgatggcc gctgctgcac tccccacaat accaaaacca tccaggcaga gtttcagtgc      360

tccccagggc aaatagtcaa gaagccagtg atggtcattg ggacctgcac ctgtcacacc      420

aactgtccta agaacaatga ggccttcctc caggagctgg agctgaagac taccagaggg      480

aaaatg                                                                 486


<210>  25
<211>  480
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 12

<400>  25
gaagtctctg actcaagtgt caactgcatt gaacagacca cagagtggac agcatgctcc       60

aagagctgtg gtatggggtt ctccacccgg gtcaccaata ggaaccgtca atgtgagatg      120

ctgaaacaga ctcggctctg catggtgcgg ccctgtgaac aagagccaga gcagccaaca      180

gataagaaag gaaaaaagtg tctccgcacc aagaagtcac tcaaagccat ccacctgcag      240

ttcaagaact gcaccagcct gcacacctac aagcccaggt tctgtggggt ctgcagtgat      300

ggccgctgct gcactcccca caataccaaa accatccagg cagagtttca gtgctcccca      360

gggcaaatag tcaagaagcc agtgatggtc attgggacct gcacctgtca caccaactgt      420

cctaagaaca atgaggcctt cctccaggag ctggagctga agactaccag agggaaaatg      480


<210>  26
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 13

<400>  26
gtctctgact caagtgtcaa ctgcattgaa cagaccacag agtggacagc atgctccaag       60

agctgtggta tggggttctc cacccgggtc accaatagga accgtcaatg tgagatgctg      120

aaacagactc ggctctgcat ggtgcggccc tgtgaacaag agccagagca gccaacagat      180

aagaaaggaa aaaagtgtct ccgcaccaag aagtcactca aagccatcca cctgcagttc      240

aagaactgca ccagcctgca cacctacaag cccaggttct gtggggtctg cagtgatggc      300

cgctgctgca ctccccacaa taccaaaacc atccaggcag agtttcagtg ctccccaggg      360

caaatagtca agaagccagt gatggtcatt gggacctgca cctgtcacac caactgtcct      420

aagaacaatg aggccttcct ccaggagctg gagctgaaga ctaccagagg gaaaatg         477


<210>  27
<211>  474
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid coding SEQ ID NO: 14

<400>  27
tctgactcaa gtgtcaactg cattgaacag accacagagt ggacagcatg ctccaagagc       60

tgtggtatgg ggttctccac ccgggtcacc aataggaacc gtcaatgtga gatgctgaaa      120

cagactcggc tctgcatggt gcggccctgt gaacaagagc cagagcagcc aacagataag      180

aaaggaaaaa agtgtctccg caccaagaag tcactcaaag ccatccacct gcagttcaag      240

aactgcacca gcctgcacac ctacaagccc aggttctgtg gggtctgcag tgatggccgc      300

tgctgcactc cccacaatac caaaaccatc caggcagagt ttcagtgctc cccagggcaa      360

atagtcaaga agccagtgat ggtcattggg acctgcacct gtcacaccaa ctgtcctaag      420

aacaatgagg ccttcctcca ggagctggag ctgaagacta ccagagggaa aatg            474


