				SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
       
 
<120>  Combination therapy of an afucosylated CD20 antibody with a CD79b antibody-drug conjugate


<130>  31511 and PR5608

<140>
<141>

<150>  US 61/818821
<151>  2013-05-02

<160>  182    

<170>  PatentIn version 3.2

<210>  1
<211>  112
<212>  PRT
<213>  Mus sp.


<220>
<221>  MISC_FEATURE
<223>  amino acid sequence of variable region of the heavy chain (VH) of
       murine monoclonal anti-CD20 antibody B-Ly1

<400>  1

Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys 
1               5                   10                  15      


Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Met Asn Trp Val Lys Leu 
            20                  25                  30          


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Phe Pro Gly Asp 
        35                  40                  45              


Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr 
    50                  55                  60                  


Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Thr Ser Leu Thr 
65                  70                  75                  80  


Ser Val Asp Ser Ala Val Tyr Leu Cys Ala Arg Asn Val Phe Asp Gly 
                85                  90                  95      


Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


<210>  2
<211>  103
<212>  PRT
<213>  Mus sp.


<220>
<221>  MISC_FEATURE
<223>  amino acid sequence of variable region of the light chain (VL) of
       murine monoclonal anti-CD20 antibody B-Ly1

<400>  2

Asn Pro Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser 
1               5                   10                  15      


Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu 
            20                  25                  30          


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn 
        35                  40                  45              


Leu Val Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys Arg 
            100             


<210>  3
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HH2)

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  4
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HH3)

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HH4)

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HH5)

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HH6)

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HH7)

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HH8)

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HH9)

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL8)

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL10)

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL11)

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL12)

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Ala Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL13)

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL14)

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Lys Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL15)

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL16)

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the heavy chain (VH) 
       of humanized B-Ly1 antibody (B-HL17)

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequences of variable region of the light chain (VL) 
       of humanized B-Ly1 antibody B-KV1

<400>  20

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val 
        115 


<210> 21
<211> 1270
<212> DNA
<213> Homo sapiens

<400> 21
 caggggacag gctgcagccg gtgcagttac acgttttcct ccaaggagcc 50

 tcggacgttg tcacgggttt ggggtcgggg acagagcagt gaccatggcc 100

 aggctggcgt tgtctcctgt gcccagccac tggatggtgg cgttgctgct 150

 gctgctctca gctgagccag taccagcagc cagatcggag gaccggtacc 200

 ggaatcccaa aggtagtgct tgttcgcgga tctggcagag cccacgtttc 250

 atagccagga aacggggctt cacggtgaaa atgcactgct acatgaacag 300

 cgcctccggc aatgtgagct ggctctggaa gcaggagatg gacgagaatc 350

 cccagcagct gaagctggaa aagggccgca tggaagagtc ccagaacgaa 400

 tctctcgcca ccctcaccat ccaaggcatc cggtttgagg acaatggcat 450

 ctacttctgt cagcagaagt gcaacaacac ctcggaggtc taccagggct 500

 gcggcacaga gctgcgagtc atgggattca gcaccttggc acagctgaag 550

 cagaggaaca cgctgaagga tggtatcatc atgatccaga cgctgctgat 600

 catcctcttc atcatcgtgc ctatcttcct gctgctggac aaggatgaca 650

 gcaaggctgg catggaggaa gatcacacct acgagggcct ggacattgac 700

 cagacagcca cctatgagga catagtgacg ctgcggacag gggaagtgaa 750

 gtggtctgta ggtgagcacc caggccagga gtgagagcca ggtcgcccca 800

 tgacctgggt gcaggctccc tggcctcagt gactgcttcg gagctgcctg 850

 gctcatggcc caaccccttt cctggacccc ccagctggcc tctgaagctg 900

 gcccaccaga gctgccattt gtctccagcc cctggtcccc agctcttgcc 950

 aaagggcctg gagtagaagg acaacagggc agcaacttgg agggagttct 1000

 ctggggatgg acgggaccca gccttctggg ggtgctatga ggtgatccgt 1050

 ccccacacat gggatggggg aggcagagac tggtccagag cccgcaaatg 1100

 gactcggagc cgagggcctc ccagcagagc ttgggaaggg ccatggaccc 1150

 aactgggccc cagaagagcc acaggaacat cattcctctc ccgcaaccac 1200

 tcccacccca gggaggccct ggcctccagt gccttccccc gtggaataaa 1250

 cggtgtgtcc tgagaaacca 1270

<210> 22
<211> 229
<212> PRT
<213> Homo sapiens

<400> 22
 Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val
   1               5                  10                  15

 Ala Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg
                  20                  25                  30

 Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg
                  35                  40                  45

 Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr
                  50                  55                  60

 Val Lys Met His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser
                  65                  70                  75

 Trp Leu Trp Lys Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys
                  80                  85                  90

 Leu Glu Lys Gly Arg Met Glu Glu Ser Gln Asn Glu Ser Leu Ala
                  95                 100                 105

 Thr Leu Thr Ile Gln Gly Ile Arg Phe Glu Asp Asn Gly Ile Tyr
                 110                 115                 120

 Phe Cys Gln Gln Lys Cys Asn Asn Thr Ser Glu Val Tyr Gln Gly
                 125                 130                 135

 Cys Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu Ala Gln
                 140                 145                 150

 Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln
                 155                 160                 165

 Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu
                 170                 175                 180

 Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr
                 185                 190                 195

 Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile
                 200                 205                 210

 Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His
                 215                 220                 225

 Pro Gly Gln Glu
              

<210> 23
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light Chain of Chimeric Antibody (chMA79b)

<400> 23
 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly
                  95                 100                 105

 Thr Glu Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            


<210> 24
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy Chain of Chimeric Antibody (chMA79b)

<400> 24
 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser
                  65                  70                  75

 Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    


<210> 25
<211> 108
<212> PRT
<213> Homo sapiens

<400> 25
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
                  20                  25                  30

 Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Tyr Asn Ser Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 26
<211> 111
<212> PRT
<213> Artificial sequence

<220>
<223> Variable domain of Light Chain of Chimeric Antibody (chMA79b)

<400> 26
 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Lys Pro Gly Gln
                  35                  40                  45

 Pro Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly
                  50                  55                  60

 Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                  65                  70                  75

 Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr
                  80                  85                  90

 Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr
                  95                 100                 105

 Glu Leu Glu Leu Lys Arg
                 110    

<210> 27
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> Variable Domain of LIght Chain of Humanized Antibody Graft (huMA79b graft)

<400> 27
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

  
<210> 28
<211> 113
<212> PRT
<213> Homo sapiens

<400> 28
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ser Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Phe Asp Tyr Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser
                 110            

<210> 29
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Variable domain of Heavy Chain of Chimeric Antibody (chMA79b)

<400> 29
 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser
                  65                  70                  75

 Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
                 110                 115        

<210> 30
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> Variable Domain of Heavy Chain of Humanized Antibody Graft (huMA79b graft)

<400> 30
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR1-LC of huMA79b graft

<400> 31
 Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR2-LC of huMA79b graft

<400> 32
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR3-LC of huMA79b graft

<400> 33
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR1-HC of huMA79b graft

<400> 34
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 35
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR2-HC of huMA79b graft

<400> 35
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 36
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR3-HC of huMA79b graft

<400> 36
 Thr Arg Arg Val Pro Val Tyr Phe Asp Tyr
                   5                  10

<210> 37
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b. V28)

<400> 37
 Lys Ala Ser Gln Ser Val Asp Tyr Glu Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 38
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (huMA79b. V28)

<400> 38
 Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr
                   5                  10

<210> 39
<211> 23
<212> PRT
<213> Homo sapiens

<400> 39
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 40
<211> 15
<212> PRT
<213> Homo sapiens

<400> 40
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 41
<211> 32
<212> PRT
<213> Homo sapiens

<400> 41
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 42
<211> 11
<212> PRT
<213> Homo sapiens

<400> 42
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 43
<211> 25
<212> PRT
<213> Homo sapiens

<400> 43
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 44
<211> 13
<212> PRT
<213> Homo sapiens

<400> 44
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                   5                  10            

<210> 45
<211> 30
<212> PRT
<213> Homo sapiens

<400> 45
 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 46
<211> 11
<212> PRT
<213> Homo sapiens

<400> 46
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 47
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 47
 Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 48
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 48
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 49
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 49
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 50
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 50
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 51
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 51
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 52
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-H3 of Humanized Antibody Variant (huMA79b.v17)

<400> 52
 Thr Arg Arg Val Pro Val Tyr Phe Asp Tyr
                   5                  10


<210> 53
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> LC-HC Variety Domain of Humanized Antibody Varient(huMA79b.v17)

<400> 53
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 54
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> HC-Variable Domain of Humanized Antibody Variant (huMA79b.v17)

<400> 54
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        

<210> 55
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 55
 Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 56
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 56
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 57
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 57
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 58
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 58
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 59
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 59
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 60
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 60
 Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr
                   5                  10

<210> 61
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> LC-Variable Domain of Humanized Antibody Variant (huMA79b.v18)

<400> 61
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 62
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> HC-Variable Domain of Humanized Antibody Variant (huMA79b.v18)

<400> 62
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        

<210> 63
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 63
 Lys Ala Ser Gln Ser Val Asp Tyr Glu Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 64
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 64
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 65
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 65
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 66
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 66
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 67
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-HLC of Humanized Antibody Variant (huMA79b.v28)

<400> 67
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 68
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 68
 Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr
                   5                  10


<210> 69
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> LC-variable domain of (huMA79b.v28)

<400> 69
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Glu Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 70
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> HC-Variable Domain of Humanized Antibody (huMA79b.v28)

<400> 70
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        


<210> 71
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 71
 Lys Ala Ser Gln Ser Val Asp Tyr Ser Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 72
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 72
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 73
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 73
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 74
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 74
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 75
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 75
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 76
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 76
 Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr
                   5                  10

<210> 77
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> LC -Variable Domain of Humanized Antibody Variant (huMA79b.v32)

<400> 77
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Ser Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 78
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> HC-Variable Domain of Humanized Antibody Variant (huMA79b.v32)

<400> 78
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        


<210> 79
<211> 893
<212> DNA
<213> Macaca fascicularis

<400> 79
 tcatggtgat ggtgatgatg accggtacgc gtagaatcga gaccgaggag 50

 agggttaggg ataggcttac cttcgaaccg cgggccctct agactcgagc 100

 ggccgccact gtgctggata tctgcagaat tgcccttggg gacagagcag 150

 tgaccatggc caggctggcg ttgtctcctg tgtccagcca ctggctggtg 200

 gcgttgctgc tgctgctctc agcagctgag ccagtgccag cagccaaatc 250

 agaggacctg tacccgaatc ccaaaggtag tgcttgttct cggatctggc 300

 agagcccacg tttcatagcc aggaaacggg gcttcacggt gaaaatgcac 350

 tgctacgtga ccaacagcac cttcagcatc gtgagctggc tccggaagcg 400

 ggagacggac aaggagcccc aacaggtgaa cctggagcag ggccacatgc 450

 atcagaccca aaacagctct gtcaccaccc tcatcatcca agacatccgg 500

 tttgaggaca acggcatcta cttctgtcag caggagtgca gcaagacctc 550

 ggaggtctac cggggctgcg gcacggagct gcgagtcatg gggttcagca 600

 ccttggcaca gctgaagcag aggaacacgc tgaaggatgg catcatcatg 650

 atccagacgc tgctgatcat cctcttcatc atcgtgccca tcttcctgct 700

 gctggacaag gatgacagca aggccggcat ggaggaagat cacacctacg 750

 agggcctgga cattgaccag acggccacct acgaggacat agtgacgctg 800

 cggacagggg aagtgaagtg gtctgtgggt gagcacccag gtcaggagtg 850

 agagccagga cctccccacg gcctgggtgc aggctcccca  gcc 893

<210> 80
<211> 231
<212> PRT
<213> Macaca fascicularis

<400> 80
 Met Ala Arg Leu Ala Leu Ser Pro Val Ser Ser His Trp Leu Val
   1               5                  10                  15

 Ala Leu Leu Leu Leu Leu Ser Ala Ala Glu Pro Val Pro Ala Ala
                  20                  25                  30

 Lys Ser Glu Asp Leu Tyr Pro Asn Pro Lys Gly Ser Ala Cys Ser
                  35                  40                  45

 Arg Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe
                  50                  55                  60

 Thr Val Lys Met His Cys Tyr Val Thr Asn Ser Thr Phe Ser Ile
                  65                  70                  75

 Val Ser Trp Leu Arg Lys Arg Glu Thr Asp Lys Glu Pro Gln Gln
                  80                  85                  90

 Val Asn Leu Glu Gln Gly His Met His Gln Thr Gln Asn Ser Ser
                  95                 100                 105

 Val Thr Thr Leu Ile Ile Gln Asp Ile Arg Phe Glu Asp Asn Gly
                 110                 115                 120

 Ile Tyr Phe Cys Gln Gln Glu Cys Ser Lys Thr Ser Glu Val Tyr
                 125                 130                 135

 Arg Gly Cys Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu
                 140                 145                 150

 Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met
                 155                 160                 165

 Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe
                 170                 175                 180

 Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp
                 185                 190                 195

 His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
                 200                 205                 210

 Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly
                 215                 220                 225

 Glu His Pro Gly Gln Glu
                 230    

<210> 81
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Chimeric anti-cyno CD79b (ch10D10)- LC

<400> 81
 Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp
                  20                  25                  30

 Ser Tyr Gly Lys Thr Phe Met His Trp His Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Phe Thr Phe Gly Gly Gly
                  95                 100                 105

 Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 82
<211> 441
<212> PRT
<213> Artificial sequence

<220>
<223> Chimeric anti-cyno CD79b (ch10D10)- LC

<400> 82
 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Gly Asn Ile Trp Tyr Ser Gly Ser Thr Thr Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Ser Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ser Arg Met Asp Phe Trp Gly Gln Gly
                  95                 100                 105

 Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
                 110                 115                 120

 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
                 125                 130                 135

 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
                 140                 145                 150

 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                 155                 160                 165

 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
                 170                 175                 180

 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
                 185                 190                 195

 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
                 200                 205                 210

 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
                 215                 220                 225

 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                 230                 235                 240

 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                 245                 250                 255

 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
                 260                 265                 270

 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
                 275                 280                 285

 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
                 290                 295                 300

 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
                 305                 310                 315

 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                 320                 325                 330

 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
                 335                 340                 345

 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
                 350                 355                 360

 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
                 365                 370                 375

 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                 380                 385                 390

 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                 395                 400                 405

 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                 410                 415                 420

 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
                 425                 430                 435

 Leu Ser Leu Ser Pro Gly
                 440    

<210> 83
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 83
 Glu Val Gln Leu Cys Glu Ser Gly Gly Gly
                   5                  10

<210> 84
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 84
 Leu Arg Leu Ser Cys Cys Ala Ser Gly Tyr Thr
                   5                  10    

<210> 85
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 85
 Met Asn Ser Leu Arg Cys Glu Asp Thr Ala Val
                   5                  10    

<210> 86
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 86
 Thr Leu Val Thr Val Cys Ser Ala Ser Thr Lys
                   5                  10    

<210> 87
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 87
 Val Thr Val Ser Ser Cys Ser Thr Lys Gly Pro
                   5                  10    

<210> 88
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 88
 Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val
                   5                  10    

<210> 89
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 89
 Trp Tyr Val Asp Gly Cys Glu Val His Asn Ala
                   5                  10    

<210> 90
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 90
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 91
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 91
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 92
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 92
 Glu Val Gln Leu Cys Gln Ser Gly Ala Glu
                   5                  10

<210> 93
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 93
 Val Lys Ile Ser Cys Cys Ala Thr Gly Tyr Thr
                   5                  10    

<210> 94
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 94
 Leu Ser Ser Leu Thr Cys Glu Asp Ser Ala Val
                   5                  10    

<210> 95
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 95
 Thr Ser Val Thr Val Cys Ser Ala Ser Thr Lys
                   5                  10    

<210> 96
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 96
 Val Thr Val Ser Ser Cys Ser Thr Lys Gly Pro
                   5                  10    

<210> 97
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 97
 Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val
                   5                  10    

<210> 98
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 98
 Trp Tyr Val Asp Gly Cys Glu Val His Asn Ala
                   5                  10    

<210> 99
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 99
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 100
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 100
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 101
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 101
 Glu Val Gln Leu Cys Glu Ser Gly Pro Gly
                   5                  10

<210> 102
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 102
 Leu Ser Leu Thr Cys Cys Val Thr Gly Tyr Ser
                   5                  10    

<210> 103
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 103
 Leu Asn Ser Val Thr Cys Glu Asp Thr Ala Thr
                   5                  10    

<210> 104
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 104
 Thr Thr Leu Thr Val Cys Ser Ala Ser Thr Lys
                   5                  10    

<210> 15
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 105
 Leu Thr Val Ser Ser Cys Ser Thr Lys Gly Pro
                   5                  10    

<210> 106
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 106
 Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val
                   5                  10    

<210> 107
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-cynoCD79b (ch10D10)-HC-variant

<400> 107
 Trp Tyr Val Asp Gly Cys Glu Val His Asn Ala
                   5                  10    

<210> 108
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 108
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 109
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 109
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 110
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 110
 Ser Leu Ser Ala Ser Cys Gly Asp Arg Val Thr
                   5                  10    

<210> 111
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 111
 Glu Ile Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 112
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 112
 Thr Val Ala Ala Pro Cys Val Phe Ile Phe Pro
                   5                  10    

<210> 113
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 113
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 114
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 114
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 115
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 115
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 116
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 116
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

<210> 117
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 117
 Ser Leu Ala Val Ser Cys Gly Gln Arg Ala Thr
                   5                  10    

<210> 118
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 118
 Glu Leu Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 119
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 119
 Thr Val Ala Ala Pro Cys Val Phe Ile Phe Pro
                   5                  10    

<210> 120
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 120
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 121
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 121
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 122
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 122
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 123
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 123
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

<210> 124
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 124
 Ser Leu Ala Val Ser Cys Gly Gln Arg Ala Thr
                   5                  10    

<210> 125
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 125
 Glu Ile Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 126
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 126
 Thr Val Ala Ala Pro Cys Val Phe Ile Phe Pro
                   5                  10    

<210> 127
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 127
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 128
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 128
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 129
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 129
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 130
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 130
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

<210> 131
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 131
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 132
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-LC Humanized Antibody variant huMA79b.v17)

<400> 132
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 133
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-LC of Humanized Antibody variant (huMA79b.v17)

<400> 133
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 134
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 134
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 135
<211> 106
<212> PRT
<213> Artificial sequence

<220>
<223> CL1-LC ofHumanized Antibody Variant (huMA79b.v17)

<400> 135
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 136
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 136
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 137
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 137
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 138
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 138
 Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 139
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 139
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 140
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1-HC of Humanized Antibody Varient (huMA79b.v17)

<400> 140
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 141
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 141
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 142
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 142
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 143
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 143
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 144
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 144
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys

     
<210> 145
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 145
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 146
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of huMA79bv.32

<400> 146
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 147
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> CL1-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 147
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 148
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 148
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 149
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 149
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 150
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 150
 Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 151
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 151
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 152
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 152
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 153
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 153
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 154
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 154
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 155
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 155
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 156
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 156
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 157
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 157
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 158
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> CL1-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 158
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 159
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 159
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 160
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 160
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 161
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 161
 Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 162
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 162
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 163
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 163
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 164
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc-HC of Humanized Antibody Variant (huMA79b.V28)

<400> 164
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 165
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 165
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 166
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 166
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Phe Ile Tyr
   1               5                  10                  15

<210> 167
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 167
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 168
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 168
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 169
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> CL1-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 169
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 170
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 170
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 171
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 171
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 172
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 172
 Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 173
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 173
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 174
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 174
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 175
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 175
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 176
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain of huMA79bv.17

<400> 176
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 177
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of huMA79bv.17

<400> 177
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 178
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain of huMA79bv.18

<400> 178
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 179
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of huMA79bv.18

<400> 179
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 180
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain of huMA79bv.28

<400> 180
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Glu Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 181
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of huMA79bv.28

<400> 181
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 182
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain of huMA79bv.32

<400> 182
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Ser Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            


