                         SEQUENCE LISTING

<110>  HAGLUND, Lisbet
       ROUGHLEY, Peter
       ALKHATIB, Bashar
       OUELLET, Jean
       ONNERFJORD, Patrick
 
<120>  CHONDROADHERIN FRAGMENTS AS INDICATORS OF INTERVERTEBRAL DISC 
       DEGENERATION

<130>  55818145-1PCT

<150>  US 61/823,326
<151>  2013-05-14

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric CHAD-derived peptide

<400>  1

Tyr Leu Tyr Leu Ser Gly Gly Cys 
1               5               


<210>  2
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Leu Tyr Leu Ser 
1               5   


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Phe Arg Gly Leu Lys Gln Leu Ile 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Tyr Leu Tyr Leu Ser His Asn Asp Ile 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Leu Tyr Leu Ser His Asn Asp Ile Arg 
1               5                   10  


<210>  6
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Gln Leu Ile 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Leu Tyr Leu 
1               


<210>  8
<211>  359
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(21)

<220>
<221>  SITE
<222>  (102)..(103)
<223>  Protease cleavage site

<400>  8

Met Val Arg Pro Met Leu Leu Leu Ser Leu Gly Leu Leu Ala Gly Leu 
1               5                   10                  15      


Leu Pro Ala Leu Ala Ala Cys Pro Gln Asn Cys His Cys His Ser Asp 
            20                  25                  30          


Leu Gln His Val Ile Cys Asp Lys Val Gly Leu Gln Lys Ile Pro Lys 
        35                  40                  45              


Val Ser Glu Lys Thr Lys Leu Leu Asn Leu Gln Arg Asn Asn Phe Pro 
    50                  55                  60                  


Val Leu Ala Ala Asn Ser Phe Arg Ala Met Pro Asn Leu Val Ser Leu 
65                  70                  75                  80  


His Leu Gln His Cys Gln Ile Arg Glu Val Ala Ala Gly Ala Phe Arg 
                85                  90                  95      


Gly Leu Lys Gln Leu Ile Tyr Leu Tyr Leu Ser His Asn Asp Ile Arg 
            100                 105                 110         


Val Leu Arg Ala Gly Ala Phe Asp Asp Leu Thr Glu Leu Thr Tyr Leu 
        115                 120                 125             


Tyr Leu Asp His Asn Lys Val Thr Glu Leu Pro Arg Gly Leu Leu Ser 
    130                 135                 140                 


Pro Leu Val Asn Leu Phe Ile Leu Gln Leu Asn Asn Asn Lys Ile Arg 
145                 150                 155                 160 


Glu Leu Arg Ala Gly Ala Phe Gln Gly Ala Lys Asp Leu Arg Trp Leu 
                165                 170                 175     


Tyr Leu Ser Glu Asn Ala Leu Ser Ser Leu Gln Pro Gly Ala Leu Asp 
            180                 185                 190         


Asp Val Glu Asn Leu Ala Lys Phe His Val Asp Arg Asn Gln Leu Ser 
        195                 200                 205             


Ser Tyr Pro Ser Ala Ala Leu Ser Lys Leu Arg Val Val Glu Glu Leu 
    210                 215                 220                 


Lys Leu Ser His Asn Pro Leu Lys Ser Ile Pro Asp Asn Ala Phe Gln 
225                 230                 235                 240 


Ser Phe Gly Arg Tyr Leu Glu Thr Leu Trp Leu Asp Asn Thr Asn Leu 
                245                 250                 255     


Glu Lys Phe Ser Asp Gly Ala Phe Leu Gly Val Thr Thr Leu Lys His 
            260                 265                 270         


Val His Leu Glu Asn Asn Arg Leu Asn Gln Leu Pro Ser Asn Phe Pro 
        275                 280                 285             


Phe Asp Ser Leu Glu Thr Leu Ala Leu Thr Asn Asn Pro Trp Lys Cys 
    290                 295                 300                 


Thr Cys Gln Leu Arg Gly Leu Arg Arg Trp Leu Glu Ala Lys Ala Ser 
305                 310                 315                 320 


Arg Pro Asp Ala Thr Cys Ala Ser Pro Ala Lys Phe Lys Gly Gln His 
                325                 330                 335     


Ile Arg Asp Thr Asp Ala Phe Arg Ser Cys Lys Phe Pro Thr Lys Arg 
            340                 345                 350         


Ser Lys Lys Ala Gly Arg His 
        355                 


<210>  9
<211>  358
<212>  PRT
<213>  Mus musculus


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (101)..(102)
<223>  Protease cleavage site

<400>  9

Met Ala Arg Ala Leu Leu Phe Ser Leu Val Phe Leu Ala Ile Leu Leu 
1               5                   10                  15      


Pro Ala Leu Ala Ala Cys Pro Gln Asn Cys His Cys His Gly Asp Leu 
            20                  25                  30          


Gln His Val Ile Cys Asp Lys Val Gly Leu Gln Lys Ile Pro Lys Val 
        35                  40                  45              


Ser Glu Thr Thr Lys Leu Leu Asn Leu Gln Arg Asn Asn Phe Pro Val 
    50                  55                  60                  


Leu Ala Ala Asn Ser Phe Arg Thr Met Pro Asn Leu Val Ser Leu His 
65                  70                  75                  80  


Leu Gln His Cys Asn Ile Arg Glu Val Ala Ala Gly Ala Phe Arg Gly 
                85                  90                  95      


Leu Lys Gln Leu Ile Tyr Leu Tyr Leu Ser His Asn Asp Ile Arg Val 
            100                 105                 110         


Leu Arg Ala Gly Ala Phe Asp Asp Leu Thr Glu Leu Thr Tyr Leu Tyr 
        115                 120                 125             


Leu Asp His Asn Lys Val Ser Glu Leu Pro Arg Gly Leu Leu Ser Pro 
    130                 135                 140                 


Leu Val Asn Leu Phe Ile Leu Gln Leu Asn Asn Asn Lys Ile Arg Glu 
145                 150                 155                 160 


Leu Arg Ala Gly Ala Phe Gln Gly Ala Lys Asp Leu Arg Trp Leu Tyr 
                165                 170                 175     


Leu Ser Glu Asn Ala Leu Ser Ser Leu Gln Pro Gly Ser Leu Asp Asp 
            180                 185                 190         


Val Glu Asn Leu Ala Lys Phe His Leu Asp Lys Asn Gln Leu Ser Ser 
        195                 200                 205             


Tyr Pro Ser Ala Ala Leu Ser Lys Leu Arg Val Val Glu Glu Leu Lys 
    210                 215                 220                 


Leu Ser His Asn Pro Leu Lys Ser Ile Pro Asp Asn Ala Phe Gln Ser 
225                 230                 235                 240 


Phe Gly Arg Tyr Leu Glu Thr Leu Trp Leu Asp Asn Thr Asn Leu Glu 
                245                 250                 255     


Lys Phe Ser Asp Ala Ala Phe Ser Gly Val Thr Thr Leu Lys His Val 
            260                 265                 270         


His Leu Asp Asn Asn Arg Leu Asn Gln Leu Pro Ser Ser Phe Pro Phe 
        275                 280                 285             


Asp Asn Leu Glu Thr Leu Thr Leu Thr Asn Asn Pro Trp Lys Cys Thr 
    290                 295                 300                 


Cys Gln Leu Arg Gly Leu Arg Arg Trp Leu Glu Ala Lys Ala Ser Arg 
305                 310                 315                 320 


Pro Asp Ala Thr Cys Ser Ser Pro Ala Lys Phe Lys Gly Gln Arg Ile 
                325                 330                 335     


Arg Asp Thr Asp Ala Leu Arg Ser Cys Lys Ser Pro Thr Lys Arg Ser 
            340                 345                 350         


Lys Lys Ala Gly Arg His 
        355             


<210>  10
<211>  358
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (101)..(102)
<223>  Protease cleavage site

<400>  10

Met Ala Arg Val Leu Leu Leu Ser Leu Val Phe Leu Ala Ile Leu Leu 
1               5                   10                  15      


Pro Ala Leu Ala Ala Cys Pro Gln Asn Cys His Cys His Gly Asp Leu 
            20                  25                  30          


Gln His Val Ile Cys Asp Lys Val Gly Leu Gln Lys Ile Pro Lys Val 
        35                  40                  45              


Ser Glu Thr Thr Lys Leu Leu Asn Leu Gln Arg Asn Asn Phe Pro Val 
    50                  55                  60                  


Leu Ala Ala Asn Ser Phe Arg Thr Val Pro Asn Leu Val Ser Leu His 
65                  70                  75                  80  


Leu Gln His Cys Asn Ile Arg Glu Val Ala Ala Gly Ala Phe Arg Gly 
                85                  90                  95      


Leu Lys Gln Leu Ile Tyr Leu Tyr Leu Ser His Asn Asp Ile Arg Val 
            100                 105                 110         


Leu Arg Ala Gly Ala Phe Asp Asp Leu Thr Glu Leu Thr Tyr Leu Tyr 
        115                 120                 125             


Leu Asp His Asn Lys Val Ser Glu Leu Pro Arg Gly Leu Leu Ser Pro 
    130                 135                 140                 


Leu Val Asn Leu Phe Ile Leu Gln Leu Asn Asn Asn Lys Ile Arg Glu 
145                 150                 155                 160 


Leu Arg Ala Gly Ala Phe Gln Gly Ala Lys Asp Leu Arg Trp Leu Tyr 
                165                 170                 175     


Leu Ser Glu Asn Ala Leu Thr Ser Leu His Pro Gly Ser Leu Asp Asp 
            180                 185                 190         


Val Glu Asn Leu Ala Lys Phe His Leu Asp Arg Asn Gln Leu Ser Ser 
        195                 200                 205             


Tyr Pro Ser Ala Ala Leu Ser Lys Leu Arg Val Val Glu Glu Leu Lys 
    210                 215                 220                 


Leu Ser His Asn Pro Leu Lys Ser Ile Pro Asp Asn Ala Phe Gln Ser 
225                 230                 235                 240 


Phe Gly Arg Tyr Leu Glu Thr Leu Trp Leu Asp Asn Thr Asn Leu Glu 
                245                 250                 255     


Lys Phe Ser Asp Ala Ala Phe Ala Gly Val Thr Thr Leu Lys His Val 
            260                 265                 270         


His Leu Glu Asn Asn Arg Leu Asn Gln Leu Pro Ser Thr Phe Pro Phe 
        275                 280                 285             


Asp Asn Leu Glu Thr Leu Thr Leu Thr Asn Asn Pro Trp Lys Cys Thr 
    290                 295                 300                 


Cys Gln Leu Arg Gly Leu Arg Arg Trp Leu Glu Ala Lys Thr Ser Arg 
305                 310                 315                 320 


Pro Asp Ala Thr Cys Ser Ser Pro Ala Lys Phe Lys Gly Gln Arg Ile 
                325                 330                 335     


Arg Asp Thr Asp Ala Leu Arg Ser Cys Lys Ser Pro Thr Lys Arg Ser 
            340                 345                 350         


Lys Lys Ala Gly Arg His 
        355             


