               SEQUENCE LISTING

<110> Medizinische Hochschule Hannover

<120> Means and methods for treating cancer

<130> W1380 PCT

<150> EP13167672.8
<151> 2013-05-14

<160> 2

<170> BiSSAP 1.2

<210> 1
<211> 414
<212> PRT
<213> Homo sapiens

<220> 
<223> isocitrate dehydrogenase 1

<400> 1
Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      
Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          
Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              
Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  
Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  
Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      
Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         
Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             
Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 
Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 
Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     
Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         
Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             
Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 
Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 
Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     
Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         
Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             
Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 
Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 
Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     
Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         
Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             
Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 
Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 
Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 

<210> 2
<211> 452
<212> PRT
<213> Homo sapiens

<220> 
<223> isocitrate dehydrogenase 2

<400> 2
Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
1               5                   10                  15      
Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
            20                  25                  30          
Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys 
        35                  40                  45              
Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
    50                  55                  60                  
Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys 
65                  70                  75                  80  
Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val 
                85                  90                  95      
Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
            100                 105                 110         
Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
        115                 120                 125             
Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
    130                 135                 140                 
Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
145                 150                 155                 160 
Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                165                 170                 175     
Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe 
            180                 185                 190         
Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu 
        195                 200                 205             
Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
    210                 215                 220                 
Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile 
225                 230                 235                 240 
Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys 
                245                 250                 255     
Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
            260                 265                 270         
His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg 
        275                 280                 285             
Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
    290                 295                 300                 
Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
305                 310                 315                 320 
Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                325                 330                 335     
Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
            340                 345                 350         
Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
        355                 360                 365             
Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
    370                 375                 380                 
Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys 
385                 390                 395                 400 
Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                405                 410                 415     
Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
            420                 425                 430         
Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
        435                 440                 445             
Leu Gly Arg Gln 
    450         

