                         SEQUENCE LISTING

<110>  Novartis AG
       University of Malaga
 
<120>  Interactions of betanodaviruses in infection

<130>  PAT055759

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  3107
<212>  DNA
<213>  Striped Jack nervous necrosis virus

<400>  1
taacatcagc tcttgctctg ttgttttgaa cacttacgca aggttaccgt ttagcataca       60

atacgacaat tgtaagccat gcgccgcttt gagtttgaac tcgcacgcat gtctggagca      120

gcattttgtg tcgttacggg ctaccgcctg ttgacatcaa aatggcttgc ggatagggtt      180

gaggattatc gccaacgtgt cattgcggat cgaaaacaaa ttctccgcga cgcggcggtg      240

atccgcacga gtatccagaa gcagatggaa ctagtgcgca tttcagtgcg caagggccat      300

tcccaccagg aggctgctac cgagcggaac agcgctaccg acaccatgat cggtgtggtt      360

gagaaatgtg gctacgagcc atacattatc tcaccctcac cgcgtgagaa ggagtaccac      420

gggtcccgtc agttctatag tcttgccgac ttccgtcagg actaccgccg tgatgaaatc      480

actgaccggc acgttatcgt gatgactgac gttgactatt acgtggatat gcacgaattg      540

gttggccttg gcgttccgat cctgttgtac acgttccaac ccagcactgt gtccggggaa      600

gttaaggatg gttattttac cattactgac gaccacgttc actaccgtgt tgctggtggt      660

aaggacgtgc gccataggat ctggaactac aaccaggata ccatgttcgt gcgctccaaa      720

ccccgtggtt tctgggcaag tctgaaacag attttgcgcg acattactgg catcaccgct      780

ttgtgtggct acctctatct caaacttggg atagccccgt ttggcgacca ggttacgttg      840

ttcaccgttg accagttcaa gatgggtgag caccgcaaca tcgtctccat tgttcctttc      900

gcgacttgtc gctccaacct ccttaagatt agtgagtacg gtgctgaatt ggactacatg      960

cgttaccaac aacgtaataa taacgccaat ttcaatgctg ttacttacat ctctcaggag     1020

gggcccctga tcagcttggg cctggagggc aatttcgcta gtgtccaact tccgcttcag     1080

gatttcgaaa acatccgtac tgcttatgaa ctgtcgaaga ataacaattt gtcagatact     1140

gttcgtcggt cggcacgttc gtgtaaggag gcagccataa ttcacaaatg ccttcaggcc     1200

gggtgcgatc tcgctagcga ggtcgtccac aagcctggag agctggcacg ccactaccaa     1260

gctcttggtg acacgtacga catcgacccc tctgagcagg gcaaatgcta tgcccgtgag     1320

tacgctcctg ggccgctgac tcaaactgct gtatttccaa gtgagtcgcg ttccaatgag     1380

cttgccacga tcgacggtcg tatagcgggt ccgcaggcta aggcaaagag ccgcgagcac     1440

atcactccaa agatgcacaa agtggctagg gatttcgtgc gccatttggt gcccacggcc     1500

gggctcggcc gtccctatcc cctcacgtat gtcgaagagc accagaccaa gccgttacag     1560

cgggcccgga atgatgctaa tcgatatcac gatgagttca ctatgatcgt caaggcgttc     1620

caaaagaaag aagcatacaa tgccccaaac tatccgcgga acatatcaac tgtcccgcac     1680

acccaaaacg ttaagctgtc cagctacacc tacgctttca aagaagcagt cctccagcat     1740

gttccgtggt acatgccaac tcacacaccg gctgaaattg ccgaggctgt gcagagtttg     1800

gccgcaagtt ccactgagct ggttgagact gactatagca aattcgacgg cacgttcctc     1860

cgtttcatgc gggagaatgt cgaatttgcc atttacaagc gttgggtgca cctcgaccat     1920

ttaacagaat tgtccacact attgggaaat gaactccaag cacctgctgt cacccggctg     1980

ggcatcaaat atgacccaga ctgcagtcgt cttagcggtt ccgctctcac gactgacggg     2040

aacagcattg caaatgcttt cgtctcatat cttgccggcc gccaagctgg catggatgat     2100

gacgaggcat ggacttggat tggtattgtc tacggtgacg acggtcttag atccggaaac     2160

gtgtctgacg cgttgctgtc caaaactgct tcttctctcg gctttgactt gaaaatagtg     2220

aatcgtgcac ctcgcggttc tccagtgacc ttcctctcgc gagtttatct cgatccctgg     2280

tcatcaccgg cttccgtgca gtcgccgttg cgcactttgc tcaaactaca tactacctgt     2340

gacacccaat ctgacatcga agacgtcggg tgggctaaga cgcaggcgta tctagtcact     2400

gactgcttga caccttttat tggccattgg tgtcgggcct accaacgcaa ttgcactgca     2460

cgtgtggtcc aatacgcaga ctacaacgac attccgttct gggttaagaa tgaggatcat     2520

gttggaaact catggcctca gtctgactcc gtcgattgga atgacgttgt tgccaatgag     2580

ctcggcctca ccacagctga gctactcaag cacctcgcgg cgcttgatgc gtatactggt     2640

cccgtgagcg gacttccccg tctgacaaca tcactcgact tggaaccgaa gatgcctgtc     2700

gcattagacg gcgaggtcca agccggtcct agtcaacaac ctcaaactga caaggatgga     2760

acaagtccaa caggcgatcg atcagcacct cgtcgagcta gaacagctct tcaagatgct     2820

gatggacgtg cgtgtcgctc tcggcggagt gaccgtagtc caggtaaacg agatgcgaac     2880

gttcgtgata agcgccagcg ccgcagcaca acgcctccgc gctctcgccc gtcggtaccc     2940

ggcccctcta gcagtggccg cagaaccgat ggagacagag tgagaggagg agctgcacgc     3000

cagcgccagc gacgtcgctc tccagtgtag gcgagtcacc tgcccgctcc tacccccccc     3060

ggaccattgg tcccctagtc agctttatgc tgtcctacgc ttcggcg                   3107


<210>  2
<211>  983
<212>  PRT
<213>  Striped Jack nervous necrosis virus

<400>  2

Met Arg Arg Phe Glu Phe Glu Leu Ala Arg Met Ser Gly Ala Ala Phe 
1               5                   10                  15      


Cys Val Val Thr Gly Tyr Arg Leu Leu Thr Ser Lys Trp Leu Ala Asp 
            20                  25                  30          


Arg Val Glu Asp Tyr Arg Gln Arg Val Ile Ala Asp Arg Lys Gln Ile 
        35                  40                  45              


Leu Arg Asp Ala Ala Val Ile Arg Thr Ser Ile Gln Lys Gln Met Glu 
    50                  55                  60                  


Leu Val Arg Ile Ser Val Arg Lys Gly His Ser His Gln Glu Ala Ala 
65                  70                  75                  80  


Thr Glu Arg Asn Ser Ala Thr Asp Thr Met Ile Gly Val Val Glu Lys 
                85                  90                  95      


Cys Gly Tyr Glu Pro Tyr Ile Ile Ser Pro Ser Pro Arg Glu Lys Glu 
            100                 105                 110         


Tyr His Gly Ser Arg Gln Phe Tyr Ser Leu Ala Asp Phe Arg Gln Asp 
        115                 120                 125             


Tyr Arg Arg Asp Glu Ile Thr Asp Arg His Val Ile Val Met Thr Asp 
    130                 135                 140                 


Val Asp Tyr Tyr Val Asp Met His Glu Leu Val Gly Leu Gly Val Pro 
145                 150                 155                 160 


Ile Leu Leu Tyr Thr Phe Gln Pro Ser Thr Val Ser Gly Glu Val Lys 
                165                 170                 175     


Asp Gly Tyr Phe Thr Ile Thr Asp Asp His Val His Tyr Arg Val Ala 
            180                 185                 190         


Gly Gly Lys Asp Val Arg His Arg Ile Trp Asn Tyr Asn Gln Asp Thr 
        195                 200                 205             


Met Phe Val Arg Ser Lys Pro Arg Gly Phe Trp Ala Ser Leu Lys Gln 
    210                 215                 220                 


Ile Leu Arg Asp Ile Thr Gly Ile Thr Ala Leu Cys Gly Tyr Leu Tyr 
225                 230                 235                 240 


Leu Lys Leu Gly Ile Ala Pro Phe Gly Asp Gln Val Thr Leu Phe Thr 
                245                 250                 255     


Val Asp Gln Phe Lys Met Gly Glu His Arg Asn Ile Val Ser Ile Val 
            260                 265                 270         


Pro Phe Ala Thr Cys Arg Ser Asn Leu Leu Lys Ile Ser Glu Tyr Gly 
        275                 280                 285             


Ala Glu Leu Asp Tyr Met Arg Tyr Gln Gln Arg Asn Asn Asn Ala Asn 
    290                 295                 300                 


Phe Asn Ala Val Thr Tyr Ile Ser Gln Glu Gly Pro Leu Ile Ser Leu 
305                 310                 315                 320 


Gly Leu Glu Gly Asn Phe Ala Ser Val Gln Leu Pro Leu Gln Asp Phe 
                325                 330                 335     


Glu Asn Ile Arg Thr Ala Tyr Glu Leu Ser Lys Asn Asn Asn Leu Ser 
            340                 345                 350         


Asp Thr Val Arg Arg Ser Ala Arg Ser Cys Lys Glu Ala Ala Ile Ile 
        355                 360                 365             


His Lys Cys Leu Gln Ala Gly Cys Asp Leu Ala Ser Glu Val Val His 
    370                 375                 380                 


Lys Pro Gly Glu Leu Ala Arg His Tyr Gln Ala Leu Gly Asp Thr Tyr 
385                 390                 395                 400 


Asp Ile Asp Pro Ser Glu Gln Gly Lys Cys Tyr Ala Arg Glu Tyr Ala 
                405                 410                 415     


Pro Gly Pro Leu Thr Gln Thr Ala Val Phe Pro Ser Glu Ser Arg Ser 
            420                 425                 430         


Asn Glu Leu Ala Thr Ile Asp Gly Arg Ile Ala Gly Pro Gln Ala Lys 
        435                 440                 445             


Ala Lys Ser Arg Glu His Ile Thr Pro Lys Met His Lys Val Ala Arg 
    450                 455                 460                 


Asp Phe Val Arg His Leu Val Pro Thr Ala Gly Leu Gly Arg Pro Tyr 
465                 470                 475                 480 


Pro Leu Thr Tyr Val Glu Glu His Gln Thr Lys Pro Leu Gln Arg Ala 
                485                 490                 495     


Arg Asn Asp Ala Asn Arg Tyr His Asp Glu Phe Thr Met Ile Val Lys 
            500                 505                 510         


Ala Phe Gln Lys Lys Glu Ala Tyr Asn Ala Pro Asn Tyr Pro Arg Asn 
        515                 520                 525             


Ile Ser Thr Val Pro His Thr Gln Asn Val Lys Leu Ser Ser Tyr Thr 
    530                 535                 540                 


Tyr Ala Phe Lys Glu Ala Val Leu Gln His Val Pro Trp Tyr Met Pro 
545                 550                 555                 560 


Thr His Thr Pro Ala Glu Ile Ala Glu Ala Val Gln Ser Leu Ala Ala 
                565                 570                 575     


Ser Ser Thr Glu Leu Val Glu Thr Asp Tyr Ser Lys Phe Asp Gly Thr 
            580                 585                 590         


Phe Leu Arg Phe Met Arg Glu Asn Val Glu Phe Ala Ile Tyr Lys Arg 
        595                 600                 605             


Trp Val His Leu Asp His Leu Thr Glu Leu Ser Thr Leu Leu Gly Asn 
    610                 615                 620                 


Glu Leu Gln Ala Pro Ala Val Thr Arg Leu Gly Ile Lys Tyr Asp Pro 
625                 630                 635                 640 


Asp Cys Ser Arg Leu Ser Gly Ser Ala Leu Thr Thr Asp Gly Asn Ser 
                645                 650                 655     


Ile Ala Asn Ala Phe Val Ser Tyr Leu Ala Gly Arg Gln Ala Gly Met 
            660                 665                 670         


Asp Asp Asp Glu Ala Trp Thr Trp Ile Gly Ile Val Tyr Gly Asp Asp 
        675                 680                 685             


Gly Leu Arg Ser Gly Asn Val Ser Asp Ala Leu Leu Ser Lys Thr Ala 
    690                 695                 700                 


Ser Ser Leu Gly Phe Asp Leu Lys Ile Val Asn Arg Ala Pro Arg Gly 
705                 710                 715                 720 


Ser Pro Val Thr Phe Leu Ser Arg Val Tyr Leu Asp Pro Trp Ser Ser 
                725                 730                 735     


Pro Ala Ser Val Gln Ser Pro Leu Arg Thr Leu Leu Lys Leu His Thr 
            740                 745                 750         


Thr Cys Asp Thr Gln Ser Asp Ile Glu Asp Val Gly Trp Ala Lys Thr 
        755                 760                 765             


Gln Ala Tyr Leu Val Thr Asp Cys Leu Thr Pro Phe Ile Gly His Trp 
    770                 775                 780                 


Cys Arg Ala Tyr Gln Arg Asn Cys Thr Ala Arg Val Val Gln Tyr Ala 
785                 790                 795                 800 


Asp Tyr Asn Asp Ile Pro Phe Trp Val Lys Asn Glu Asp His Val Gly 
                805                 810                 815     


Asn Ser Trp Pro Gln Ser Asp Ser Val Asp Trp Asn Asp Val Val Ala 
            820                 825                 830         


Asn Glu Leu Gly Leu Thr Thr Ala Glu Leu Leu Lys His Leu Ala Ala 
        835                 840                 845             


Leu Asp Ala Tyr Thr Gly Pro Val Ser Gly Leu Pro Arg Leu Thr Thr 
    850                 855                 860                 


Ser Leu Asp Leu Glu Pro Lys Met Pro Val Ala Leu Asp Gly Glu Val 
865                 870                 875                 880 


Gln Ala Gly Pro Ser Gln Gln Pro Gln Thr Asp Lys Asp Gly Thr Ser 
                885                 890                 895     


Pro Thr Gly Asp Arg Ser Ala Pro Arg Arg Ala Arg Thr Ala Leu Gln 
            900                 905                 910         


Asp Ala Asp Gly Arg Ala Cys Arg Ser Arg Arg Ser Asp Arg Ser Pro 
        915                 920                 925             


Gly Lys Arg Asp Ala Asn Val Arg Asp Lys Arg Gln Arg Arg Ser Thr 
    930                 935                 940                 


Thr Pro Pro Arg Ser Arg Pro Ser Val Pro Gly Pro Ser Ser Ser Gly 
945                 950                 955                 960 


Arg Arg Thr Asp Gly Asp Arg Val Arg Gly Gly Ala Ala Arg Gln Arg 
                965                 970                 975     


Gln Arg Arg Arg Ser Pro Val 
            980             


<210>  3
<211>  75
<212>  PRT
<213>  Striped Jack nervous necrosis virus

<400>  3

Met Glu Gln Val Gln Gln Ala Ile Asp Gln His Leu Val Glu Leu Glu 
1               5                   10                  15      


Gln Leu Phe Lys Met Leu Met Asp Val Arg Val Ala Leu Gly Gly Val 
            20                  25                  30          


Thr Val Val Gln Val Asn Glu Met Arg Thr Phe Val Ile Ser Ala Ser 
        35                  40                  45              


Ala Ala Ala Gln Arg Leu Arg Ala Leu Ala Arg Arg Tyr Pro Ala Pro 
    50                  55                  60                  


Leu Ala Val Ala Ala Glu Pro Met Glu Thr Glu 
65                  70                  75  


<210>  4
<211>  1421
<212>  DNA
<213>  Striped Jack nervous necrosis virus

<400>  4
taatctaaca ccgctttgca agtcaaaatg gtacgcaaag gtgataagaa attggcaaaa       60

cccccgacca caaaggccgc caattctcaa ccacgtcgac gtgcaacaca gcgccgtcgc      120

agtggtaggg ctgatgcacc cttagctaag gcatcgacta tcacgggatt tggacgtgcg      180

accaatgatg tccatatctc gggaatgtca cggatcgctc aagcagttgt tccagccggg      240

acaggaacag atggaaagat tgtcgtcgat tccacaatcg ttccagaact cctgccacgg      300

cttggacacg ctgctcgaat cttccagcga tacgctgttg aaacactgga gttcgaaatt      360

cagccaatgt gccccgcaaa cacgggcggt ggttacgttg ctggcttcct gcctgatcca      420

actgacaacg accacacctt cgatgcgctc caagcaactc gtggtgcagt cgtcgccaaa      480

tggtgggaaa gtcgaacagt ccggccccag tatactcgaa cgcttctctg gacctcaacc      540

gggaaggagc agcgattgac atcacctggc cggctggtac tcctgtgtgt tggcagcaac      600

actgatgttg tcaacgtgtc agtcatgtgt cgctggagcg ttcgccttag tgtcccgtcc      660

cttgagacac ctgaggacac caccgctcca attactaccc aggcgccact ccacaacgat      720

tccattaaca acggttacac tggatttcgt tccattctct tgggcgcgac ccaactcgac      780

ctcgctcctg caaacgctgt ctttgtcact gacaaaccgt tgcccattga ttacaatctt      840

ggagtgggcg acgtcgaccg ggccgtgtac tggcacctgc ggaagaaagc tggagacact      900

caggtacctg ctgggtactt tgactgggga ctgtgggatg actttaacaa gacattcaca      960

gttggggcac cctactactc cgaccagcaa ccacggcaaa tcttgctgcc ggctggcacg     1020

ctcttcaccc gtgttgactc ggaaaactaa ccgggtcatc cggatcccta gtgcgtatcg     1080

tggatgacca attcgagaaa ttgattacgg cactaaccac tatcaaaatt gaaattgaca     1140

acaacaagag cgaaattgaa gctatcgcta acaaattaaa cgacaaagca cccaaggagg     1200

gctcgattgc tattgttggt accattgacg gcgtacctgg aacagttgac ggcgcttacc     1260

tcgccgaacc tgtctagcgt gcttgatacg gtgccagctt caccagtctt gtccaacgcc     1320

gaggatttcc ctctttgggc ttgttgggtt accgttagct ccgcgcagtg agcaccaccg     1380

ccatgtggtt aaatggccgc tgatcgccac attactcggc g                         1421


<210>  5
<211>  340
<212>  PRT
<213>  Striped Jack nervous necrosis virus

<400>  5

Met Val Arg Lys Gly Asp Lys Lys Leu Ala Lys Pro Pro Thr Thr Lys 
1               5                   10                  15      


Ala Ala Asn Ser Gln Pro Arg Arg Arg Ala Thr Gln Arg Arg Arg Ser 
            20                  25                  30          


Gly Arg Ala Asp Ala Pro Leu Ala Lys Ala Ser Thr Ile Thr Gly Phe 
        35                  40                  45              


Gly Arg Ala Thr Asn Asp Val His Ile Ser Gly Met Ser Arg Ile Ala 
    50                  55                  60                  


Gln Ala Val Val Pro Ala Gly Thr Gly Thr Asp Gly Lys Ile Val Val 
65                  70                  75                  80  


Asp Ser Thr Ile Val Pro Glu Leu Leu Pro Arg Leu Gly His Ala Ala 
                85                  90                  95      


Arg Ile Phe Gln Arg Tyr Ala Val Glu Thr Leu Glu Phe Glu Ile Gln 
            100                 105                 110         


Pro Met Cys Pro Ala Asn Thr Gly Gly Gly Tyr Val Ala Gly Phe Leu 
        115                 120                 125             


Pro Asp Pro Thr Asp Asn Asp His Thr Phe Asp Ala Leu Gln Ala Thr 
    130                 135                 140                 


Arg Gly Ala Val Val Ala Lys Trp Trp Glu Ser Arg Thr Val Arg Pro 
145                 150                 155                 160 


Gln Tyr Thr Arg Thr Leu Leu Trp Thr Ser Thr Gly Lys Glu Gln Arg 
                165                 170                 175     


Leu Thr Ser Pro Gly Arg Leu Val Leu Leu Cys Val Gly Ser Asn Thr 
            180                 185                 190         


Asp Val Val Asn Val Ser Val Met Cys Arg Trp Ser Val Arg Leu Ser 
        195                 200                 205             


Val Pro Ser Leu Glu Thr Pro Glu Asp Thr Thr Ala Pro Ile Thr Thr 
    210                 215                 220                 


Gln Ala Pro Leu His Asn Asp Ser Ile Asn Asn Gly Tyr Thr Gly Phe 
225                 230                 235                 240 


Arg Ser Ile Leu Leu Gly Ala Thr Gln Leu Asp Leu Ala Pro Ala Asn 
                245                 250                 255     


Ala Val Phe Val Thr Asp Lys Pro Leu Pro Ile Asp Tyr Asn Leu Gly 
            260                 265                 270         


Val Gly Asp Val Asp Arg Ala Val Tyr Trp His Leu Arg Lys Lys Ala 
        275                 280                 285             


Gly Asp Thr Gln Val Pro Ala Gly Tyr Phe Asp Trp Gly Leu Trp Asp 
    290                 295                 300                 


Asp Phe Asn Lys Thr Phe Thr Val Gly Ala Pro Tyr Tyr Ser Asp Gln 
305                 310                 315                 320 


Gln Pro Arg Gln Ile Leu Leu Pro Ala Gly Thr Leu Phe Thr Arg Val 
                325                 330                 335     


Asp Ser Glu Asn 
            340 


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligo

<400>  6
gacaccaccg ctccaattac tac                                               23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligo

<400>  7
acgaaatcca gtgtaaccgt tgt                                               23


