SEQUENCE LISTING

<110>  CELLECTIS
       PREGENEN INC.


<120>  A LAGLIDADG homing endonuclease cleaving the T-cell receptor
Alpha gene and uses thereof	

<130>  P81303518PCT00

<150>  PA201370303
<151>  2013-05-31

<160>  16   

<170>  PatentIn version 3.5


<210>  1

<211>  909
<212>  DNA
<213>  Ophiostoma novo-ulmi

<220>
<223>  Wild type I-OnuI

<400>  1
atggcataca tgtcgcgcag agagtccatc aacccatgga ttctgactgg tttcgctgat     60
gccgaaggat ccttcttgct gagaatccga aacaataaca agagctccgt gggttactct    120
accgagttgg gctttcaaat cactctgcac aacaaggaca aatcgattct ggagaatatc    180
cagtcgactt ggaaggtcgg cgtgattgct aactcaggcg acaatgccgt cagtctgaaa    240
gttacgcgtt tcgaagattt gaaagtgatt atcgaccact tcgagaaata tccgctgatt    300
acccagaaat tgggcgatta caagttgttt aaacaggcat tcagcgtcat ggagaacaaa    360
gaacatctta aggagaatgg gattaaggag ctcgtacgaa tcaaagctaa gatgaattgg    420
ggtctcactg acgaattgaa aaaagcattt ccagagaaca ttagcaaaga gcgccccctt    480
atcaataaga acattccgaa tttcaaatgg ctggctggat tcacatctgg tgaaggctgc    540
ttctttgtga acttgatcaa gtccaaatct aagctgggtg tacaggttca attggtcttc    600
agcattactc agcacatcag agacaagaac ctgatgaatt cattgataac atacctaggc    660
tgtggttaca tcaaagagaa gaacaagtcc gagttcagtt ggctcgactt tgtggttacc    720
aaattcagcg atatcaacga caagatcatt ccggtattcc aggaaaatac tctgattggc    780
gtcaaactcg aggactttga agattggtgc aaggttgcca aattgatcga agagaagaaa    840
cacctgaccg aatccggttt ggatgagatt aagaaaatca agctgaacat gaacaaaggt    900
cgtgtcttc                                                            909


<210>  2

<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi

<220>
<223>  Wild type I-OnuI

<400>  2
Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  3

<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Target TCRA_S02

<400>  3
tgtctgccta ttcaccgatt tt                                              22


<210>  4

<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Target TCRA_S010

<400>  4
ctagcacagt tttgtctgtg at                                              22


<210>  5

<211>  909
<212>  DNA
<213>  artificial sequence

<220>
<223>  LHE CCR5_S02_2E5

<400>  5
atggcataca tgtcgcgcag agagtccatc aacccatgga ttctgactgg tttcgctgat     60
gccgaaggat cattcatact agacatccgc aaccgaaaca acgaaagcaa cagataccga    120
acttcgctga gattccagat caccctgcac aacaaggaca aatcgattct ggagaatatc    180
cagtcgactt ggaaggtcgg caagatcaca aacagcggcg acagagccgt catgctgagg    240
gtcacccgtt tcgaagattt gaaagtgatt atcgaccact tcgagaaata tccgctgatt    300
acccagaaat tgggcgatta caagttgttt aaacaggcat tcagcgtcat ggagaacaaa    360
gaacatctta aggagaatgg gattaaggag ctcgtacgaa tcaaagctaa gatgaattgg    420
ggtctcaatg acgaattgaa aaaagcattt ccagagaaca ttagcaaaga gcgccccctt    480
atcaataaga acattccgaa tttcaaatgg ctggctggat tcacatctgg tgaaggctac    540
ttcggcgtga acctaaaaaa ggtaaagggc aacgcaaagg tatacgtggg actgagattc    600
tcaatcacac agcacatcag agacaagaac ctgatgaatt cattgataac atacctaggc    660
tgtggttcca tcagggagaa gaacaagtct gagttcagtt ggctcgagtt cgtcgtaacc    720
aaattcagcg atatcaacga caagatcatt ccggtattcc aggaaaatac tctgattggc    780
gtcaaactcg aggactttga agattggtgc aaggttgcca aattgatcga agagaagaaa    840
cacctgaccg aatccggttt ggatgagatt aagaaaatca agctgaacat gaacaaaggt    900
cgtgtcttc                                                            909



<210>  6

<211>  303
<212>  PRT
<213>  artificial sequence

<220>
<223>  LHE CCR5_S02_2E5

<400>  6
Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg 
            20                  25                  30          


Asn Asn Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Thr Asn Ser Gly Asp Arg Ala Val Met Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Asn Ala 
            180                 185                 190         


Lys Val Tyr Val Gly Leu Arg Phe Ser Ile Thr Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile 
    210                 215                 220                 


Arg Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Glu Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  7

<211>  909
<212>  DNA
<213>  artificial sequence

<220>
<223>  LHE TCRA_S02_2E5_RD1_08

<400>  7
atggcataca tgtcgcgcag agagtccatc aacccatgga ttctgactgg tttcgctgat     60
gccgaaggat cattcatact agacatccgc aaccgaaaca acgaaagcaa cagataccga    120
acttcgctga gattccagat caccctgcac aacaaggaca aatcgattct ggagaatatc    180
cagtcgactt ggaaggtcgg caagatcaca aacagcggcg acagagccgt catgctgagg    240
gtcacccgtt tcgaagattt gaaagtgatt atcgaccact tcgagaaata tccgctgatt    300
acccagaaat tgggcgatta caagttgttt aaacaggcat tcagcgtcat ggagaacaaa    360
gaacatctta aggagaatgg gattaaggag ctcgtacgaa tcaaagctaa gatgaattgg    420
ggtctcaacg acgaattgaa aaaagcattt ccagagaaca ttagcaaaga gcgccccctt    480
atcaataaga acattccgaa tttcaaatgg ctggctggat tcacatctgg tgagggctac    540
ttcggcgtga atctaaaaaa ggtaaagggc aacgcaaagg tatacgtggg actgagattc    600
tcaatctcac agcacatcag agacaagaac ctgatgaatt cattgataac atacctaggc    660
tgtggttcca tctgggagaa gaacaagtct gagttcagtt ggctcgagtt cgtcgtaacc    720
aaattcagcg atatcaacga caagatcatt ccggtattcc aggaaaatac tctgattggc    780
gtcaaactcg aggactttga agattggtgc aaggttgcca aattgatcga agagaagaaa    840
cacctgaccg aatccggttt ggatgagatt aagaaaatca agctgaacat gaacaaaggt    900
cgtgtcttc                                                            909


<210>  8

<211>  303
<212>  PRT
<213>  artificial sequence

<220>
<223>  LHE TCRA_S02_2E5_RD1_08

<400>  8
Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg 
            20                  25                  30          


Asn Asn Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Thr Asn Ser Gly Asp Arg Ala Val Met Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Asn Ala 
            180                 185                 190         


Lys Val Tyr Val Gly Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile 
    210                 215                 220                 


Trp Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Glu Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  9

<211>  909
<212>  DNA
<213>  artificial sequence

<220>
<223>  LHE TCRA_S02_2E5_RD2_23

<400>  9
atggcataca tgtcgcgcag agagtccatc aacccatgga ttctgactgg tttcgctgat     60
gccgaaggat cattcatact agacatccgc aaccgaaaca acgaaagcaa cagataccga    120
acttcgctga gattccagat caccctgcac aacaaggaca aatcgattct ggagaatatc    180
cagtcgactt ggaaggtcgg caagatcaca aacagcagtg acagagccgt catgctgagg    240
gtcacccgtt tcgaagattt gaaagtgatt atcgaccact tcgagaaata tccgctgatt    300
acccagaaat tgggcgatta caagttgttt aaacaggcat tcagcgtcat ggagaataaa    360
gaacatctta aggagaatgg gattaaggag ctcgtacgaa tcaaagctaa gatgaattgg    420
ggtctcaatg acgaattgaa aaaagcattt ccagagaaca ttagcaaaga gcgccccctt    480
atcaataaga acattccgaa tttcaaatgg ctggctggat tcacagctgg tgaaggctac    540
ttcggcgtga atctaaaaaa ggtaaagggc accgcaaagg tatacgtggg actgagattc    600
tcaatctcac agcacatcag agacaagaac ctgatgaatt cattgataac atacctaggc    660
tgtggttcca tctgggagaa gaacaagtct gagttcagat ggctcgagtt cgtcgtaacc    720
aaattcagcg atatcaacga caagatcatt ccggtattcc aggaaaatac tctgattggc    780
gtcaaactcg aggactttga agattggtgc aaggttgcca aattgatcga agagaagaaa    840
cacctgaccg aatccggttt ggatgagatt aagaaaatca agctgaacat gaacaaaggt    900
cgtgtcttc                                                            909


<210>  10

<211>  303
<212>  PRT
<213>  artificial sequence

<220>
<223>  LHE TCRA_S02_2E5_RD2_23

<400>  10
Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg 
            20                  25                  30          


Asn Asn Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Thr Asn Ser Ser Asp Arg Ala Val Met Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ala 
                165                 170                 175     


Gly Glu Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Thr Ala 
            180                 185                 190         


Lys Val Tyr Val Gly Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile 
    210                 215                 220                 


Trp Glu Lys Asn Lys Ser Glu Phe Arg Trp Leu Glu Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  11

<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Target Onu-I wild type

<400>  11
tttccactta ttcaaccttt ta                                              22


<210>  12

<211>  7842
<212>  DNA
<213>  artificial sequence

<220>
<223>  TCRA_S02 LHE lentiviral vector

<400>  12
gacgtcaatg tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta     60
gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg    120
gtacgatcgt gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac    180
tgaattgccg cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc    240
tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct    300
taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga    360
ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg    420
cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact    480
cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa    540
attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg    600
gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat    660
aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc    720
ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag    780
acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat    840
caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac    900
aaaagtaaga ccaccgcaca gcaagcggcc ctgatcttca gacctggagg aggagatatg    960
agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga   1020
gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata   1080
ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg   1140
acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg   1200
ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag   1260
ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt   1320
tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt   1380
aatgaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt   1440
aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag   1500
aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata   1560
acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta   1620
agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta   1680
tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa   1740
gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc tcgacggtat   1800
cggttaactt ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta   1860
gacataatag caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa   1920
aattttatcg attacgcgtc acgtgctagc tgcagtaacg ccattttgca aggcatggaa   1980
aaataccaaa ccaagaatag agaagttcag atcaagggcg ggtacatgaa aatagctaac   2040
gttgggccaa acaggatatc tgcggtgagc agtttcggcc ccggcccggg gccaagaaca   2100
gatggtcacc gcagtttcgg ccccggcccg aggccaagaa cagatggtcc ccagatatgg   2160
cccaaccctc agcagtttct taagacccat cagatgtttc caggctcccc caaggacctg   2220
aaatgaccct gcgccttatt tgaattaacc aatcagcctg cttctcgctt ctgttcgcgc   2280
gcttctgctt cccgagctct ataaaagagc tcacaacccc tcactcggcg cgccagtcct   2340
ccgacagact gagtcgcccg ctcgagccgc caccatggga tatccatacg atgtcccaga   2400
ttatgcgcca cctaagaaga aacgcaaagt cacgcgatcg cgcagagagt ccatcaaccc   2460
atggattctg actggtttcg ctgatgccga aggatcattc atactagaca tccgcaaccg   2520
aaacaacgaa agcaacagat accgaacttc gctgagattc cagatcaccc tgcacaacaa   2580
ggacaaatcg attctggaga atatccagtc gacttggaag gtcggcaaga tcacaaacag   2640
cagtgacaga gccgtcatgc tgagggtcac ccgtttcgaa gatttgaaag tgattatcga   2700
ccacttcgag aaatatccgc tgattaccca gaaattgggc gattacaagt tgtttaaaca   2760
ggcattcagc gtcatggaga ataaagaaca tcttaaggag aatgggatta aggagctcgt   2820
acgaatcaaa gctaagatga attggggtct caatgacgaa ttgaaaaaag catttccaga   2880
gaacattagc aaagagcgcc cccttatcaa taagaacatt ccgaatttca aatggctggc   2940
tggattcaca gctggtgaag gctacttcgg cgtgaatcta aaaaaggtaa agggcaccgc   3000
aaaggtatac gtgggactga gattctcaat ctcacagcac atcagagaca agaacctgat   3060
gaattcattg ataacatacc taggctgtgg ttccatctgg gagaagaaca agtctgagtt   3120
cagatggctc gagttcgtcg taaccaaatt cagcgatatc aacgacaaga tcattccggt   3180
attccaggaa aatactctga ttggcgtcaa actcgaggac tttgaagatt ggtgcaaggt   3240
tgccaaattg atcgaagaga agaaacacct gaccgaatcc ggtttggatg agattaagaa   3300
aatcaagctg aacatgaaca aaggtcgtgt cttcagcggc cgctcctgat agtaatgacc   3360
tgcaggtcga gcatgcatct agggcggcca attccgcccc tctccccccc ccccctctcc   3420
ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt gtgcgtttgt   3480
ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc ggaaacctgg   3540
ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag gaatgcaagg   3600
tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac aaacaacgtc   3660
tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc tctgcggcca   3720
aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag   3780
ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca aggggctgaa   3840
ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt gcacatgctt   3900
tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt   3960
tttcctttga aaaacacgat gataagcttg ccacaaccct taccggtcgc caccatgagc   4020
gagctgatta aggagaacat gcacatgaag ctgtacatgg agggcaccgt ggacaaccat   4080
cacttcaagt gcacatccga gggcgaaggc aagccctacg agggcaccca gaccatgaga   4140
atcaaggtgg tcgagggcgg ccctctcccc ttcgccttcg acatcctggc tactagcttc   4200
ctctacggca gcaagacctt catcaaccac acccagggca tccccgactt cttcaagcag   4260
tccttccctg agggcttcac atgggagaga gtcaccacat acgaagacgg gggcgtgctg   4320
accgctaccc aggacaccag cctccaggac ggctgcctca tctacaacgt caagatcaga   4380
ggggtgaact tcacatccaa cggccctgtg atgcagaaga aaacactcgg ctgggaggcc   4440
ttcaccgaga cgctgtaccc cgctgacggc ggcctggaag gcagaaacga catggccctg   4500
aagctcgtgg gcgggagcca tctgatcgca aacatcaaga ccacatatag atccaagaaa   4560
cccgctaaga acctcaagat gcctggcgtc tactatgtgg actacagact ggaaagaatc   4620
aaggaggcca acaacgagac ctacgtcgag cagcacgagg tggcagtggc cagatactgc   4680
gacctcccta gcaaactggg gcacaagctt aattgattct agagtcgacc gagcatctta   4740
ccgccattta tacccatatt tgttctgttt ttcttgattt gggtatacat ttaaatgtta   4800
atagaacaaa atggtggggc aatcatttac atttttaggg atatgtaatt actagttcag   4860
gtgtattgcc acaagacaaa catgttaaga aactttcccg ttatttacgc tctgttcctg   4920
ttaatcaacc tctggattac aaaatttgtg aaagattgac tgatattctt aactatgttg   4980
ctccttttac gctgtgtgga tatgctgctt tatagcctct gtatctagct attgcttccc   5040
gtacggcttt cgttttctcc tccttgtata aatcctggtt gctgtctctt ttagaggagt   5100
tgtggcccgt tgtccgtcaa cgtggcgtgg tgtgctctgt gtttgctgac gcaaccccca   5160
ctggctgggg cattgccacc acctgtcaac tcctttctgg gactttcgct ttccccctcc   5220
cgatcgccac ggcagaactc atcgccgcct gccttgcccg ctgctggaca ggggctaggt   5280
tgctgggcac tgataattcc gtggtgttgt catcggtacc tttttaaaag aaaagggggg   5340
actggaaggg ctaattcact cccaacgaag acaagatatc ataacttcgt atagcataca   5400
ttatacgaag ttataattta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat   5460
atgtttattt gtgaaatttg tgatgctatt gctttatttg taaccattgc tttttgcttg   5520
tactgggtct ctctggttag accagatctg agcctgggag ctctctggct aactagggaa   5580
cccactgctt aagcctcaat aaagcttgcc tcgaccagcc tcgactgtgc cttctagttg   5640
ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc   5700
cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc   5760
tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag   5820
gcatgctggg gatgcggtgg gctctatggc ctgcagctgc attaatgaat cggccaacgc   5880
gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg   5940
cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta   6000
tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc   6060
aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag   6120
catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac   6180
caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc   6240
ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt   6300
aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc   6360
gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga   6420
cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta   6480
ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta   6540
tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga   6600
tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg   6660
cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag   6720
tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc   6780
tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact   6840
tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt   6900
cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta   6960
ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta   7020
tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc   7080
gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat   7140
agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt   7200
atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg   7260
tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca   7320
gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta   7380
agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg   7440
cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact   7500
ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg   7560
ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt   7620
actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga   7680
ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc   7740
atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa   7800
caaatagggg ttccgcgcac atttccccga aaagtgccac ct                      7842


<210>  13

<211>  2661
<212>  DNA
<213>  artificial sequence

<220>
<223>  MegaTal TCRA_S02

<400>  13
atgggatcct gcaggtatcc atatgatgtc ccagattatg cgccacctaa gaagaaacgc     60
aaagtcgtgg atctacgcac gctcggctac agtcagcagc agcaagagaa gatcaaaccg    120
aaggtgcgtt cgacagtggc gcagcaccac gaggcactgg tgggccatgg gtttacacac    180
gcgcacatcg ttgcgctcag ccaacacccg gcagcgttag ggaccgtcgc tgtcacgtat    240
cagcacataa tcacggcgtt gccagaggcg acacacgaag acatcgttgg cgtcggcaaa    300
cagtggtccg gcgcacgcgc cctggaggcc ttgctcacgg atgcggggga gttgagaggt    360
ccgccgttac agttggacac aggccaactt gtgaagattg caaaacgtgg cggcgtgacc    420
gcaatggagg cagtgcatgc atcgcgcaat gcactgacgg gtgcccccct gaacctgacc    480
ccggaccaag tggtggctat cgccagcaac attggcggca agcaagcgct cgaaacggtg    540
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct    600
atcgccagca acattggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg    660
ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag caacattggc    720
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc    780
ctgaccccgg accaagtggt ggctatcgcc agcaacggtg gcggcaagca agcgctcgaa    840
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgactcc ggaccaagtg    900
gtggctatcg ccagccacga tggcggcaag caagcgctcg aaacggtgca gcggctgttg    960
ccggtgctgt gccaggacca tggcctgact ccggaccaag tggtggctat cgccagccac   1020
gatggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac   1080
catggcctga ccccggacca agtggtggct atcgccagca acattggcgg caagcaagcg   1140
ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gaccccggac   1200
caagtggtgg ctatcgccag caacaatggc ggcaagcaag cgctcgaaac ggtgcagcgg   1260
ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc   1320
agcaacggtg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc   1380
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacaa tggcggcaag   1440
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc   1500
ccggaccaag tggtggctat cgccagcaac attggcggca agcaagcgct cgaaagcatt   1560
gtggcccagc tgagccggcc tgatccggcg ttggccgcgt tgaccaacga ccacctcgtc   1620
gccttggcct gcctcggcgg acgtcctgcc atggatgcag tgaaaaaggg attgccgcac   1680
gcgccggaat tgatcagaag agtcaatcgc cgtattggcg aacgcacgtc ccatcgcgtt   1740
gcgatatcta gagtgggagg aagctctcgc agagagtcca tcaacccatg gattctgact   1800
ggtttcgctg atgccgaagg atcattcata ctagacatcc gcaaccgaaa caacgaaagc   1860
aacagatacc gaacttcgct gagattccag atcaccctgc acaacaagga caaatcgatt   1920
ctggagaata tccagtcgac ttggaaggtc ggcaagatca caaacagcag tgacagagcc   1980
gtcatgctga gggtcacccg tttcgaagat ttgaaagtga ttatcgacca cttcgagaaa   2040
tatccgctga ttacccagaa attgggcgat tacaagttgt ttaaacaggc attcagcgtc   2100
atggagaata aagaacatct taaggagaat gggattaagg agctcgtacg aatcaaagct   2160
aagatgaatt ggggtctcaa tgacgaattg aaaaaagcat ttccagagaa cattagcaaa   2220
gagcgccccc ttatcaataa gaacattccg aatttcaaat ggctggctgg attcacagct   2280
ggtgaaggct acttcggcgt gaatctaaaa aaggtaaagg gcaccgcaaa ggtatacgtg   2340
ggactgagat tctcaatctc acagcacatc agagacaaga acctgatgaa ttcattgata   2400
acatacctag gctgtggttc catctgggag aagaacaagt ctgagttcag atggctcgag   2460
ttcgtcgtaa ccaaattcag cgatatcaac gacaagatca ttccggtatt ccaggaaaat   2520
actctgattg gcgtcaaact cgaggacttt gaagattggt gcaaggttgc caaattgatc   2580
gaagagaaga aacacctgac cgaatccggt ttggatgaga ttaagaaaat caagctgaac   2640
atgaacaaag gtcgtgtctt c                                             2661



<210>  14

<211>  886
<212>  PRT
<213>  artificial sequence

<220>
<223>  MegaTal TCRA_S02

<400>  14
Met Gly Ser Cys Arg Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
            20                  25                  30          


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
        35                  40                  45              


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
    50                  55                  60                  


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr 
65                  70                  75                  80  


Gln His Ile Ile Thr Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val 
                85                  90                  95      


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
            100                 105                 110         


Thr Asp Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly 
        115                 120                 125             


Gln Leu Val Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala 
    130                 135                 140                 


Val His Ala Ser Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr 
145                 150                 155                 160 


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
                165                 170                 175     


Leu Glu Thr Val Gln Arg Leu Leu Val Leu Cys Gln Asp His Gly Leu 
            180                 185                 190         


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
        195                 200                 205             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
    210                 215                 220                 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
225                 230                 235                 240 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                245                 250                 255     


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
            260                 265                 270         


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
        275                 280                 285             


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
    290                 295                 300                 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
305                 310                 315                 320 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
                325                 330                 335     


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
            340                 345                 350         


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
        355                 360                 365             


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
    370                 375                 380                 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
385                 390                 395                 400 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
                405                 410                 415     


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
            420                 425                 430         


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
        435                 440                 445             


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
    450                 455                 460                 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
465                 470                 475                 480 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
                485                 490                 495     


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
            500                 505                 510         


Lys Gln Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro 
        515                 520                 525             


Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu 
    530                 535                 540                 


Gly Gly Arg Pro Ala Met Asp Ala Val Lys Lys Gly Leu Pro His Ala 
545                 550                 555                 560 


Pro Glu Leu Ile Arg Arg Val Asn Arg Arg Ile Gly Glu Arg Thr Ser 
                565                 570                 575     


His Arg Val Ala Ile Ser Arg Val Gly Gly Ser Ser Arg Arg Glu Ser 
            580                 585                 590         


Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Ser Phe 
        595                 600                 605             


Ile Leu Asp Ile Arg Asn Arg Asn Asn Glu Ser Asn Arg Tyr Arg Thr 
    610                 615                 620                 


Ser Leu Arg Phe Gln Ile Thr Leu His Asn Lys Asp Lys Ser Ile Leu 
625                 630                 635                 640 


Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Lys Ile Thr Asn Ser Gly 
                645                 650                 655     


Asp Arg Ala Val Met Leu Arg Val Thr Arg Phe Glu Asp Leu Lys Val 
            660                 665                 670         


Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu Gly 
        675                 680                 685             


Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys Glu 
    690                 695                 700                 


His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala Lys 
705                 710                 715                 720 


Met Asn Trp Gly Leu Thr Asp Glu Leu Lys Lys Ala Phe Pro Glu Asn 
                725                 730                 735     


Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Phe Lys 
            740                 745                 750         


Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Tyr Phe Gly Val Asn Leu 
        755                 760                 765             


Lys Lys Val Lys Gly Asn Ala Lys Val Tyr Val Gly Leu Arg Phe Ser 
    770                 775                 780                 


Ile Ser Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile Thr 
785                 790                 795                 800 


Tyr Leu Gly Cys Gly Ser Ile Trp Glu Lys Asn Lys Ser Glu Phe Ser 
                805                 810                 815     


Trp Leu Glu Phe Val Val Thr Lys Phe Ser Asp Ile Asn Asp Lys Ile 
            820                 825                 830         


Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu Asp 
        835                 840                 845             


Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys His 
    850                 855                 860                 


Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn Met 
865                 870                 875                 880 


Asn Lys Gly Arg Val Phe 



<210>  15

<211>  3378
<212>  DNA
<213>  artificial sequence

<220>
<223>  MegaTal TCRA_S02_Trex2

<400>  15
atgggatcct gcaggtatcc atatgatgtc ccagattatg cgccacctaa gaagaaacgc     60
aaagtcgtgg atctacgcac gctcggctac agtcagcagc agcaagagaa gatcaaaccg    120
aaggtgcgtt cgacagtggc gcagcaccac gaggcactgg tgggccatgg gtttacacac    180
gcgcacatcg ttgcgctcag ccaacacccg gcagcgttag ggaccgtcgc tgtcacgtat    240
cagcacataa tcacggcgtt gccagaggcg acacacgaag acatcgttgg cgtcggcaaa    300
cagtggtccg gcgcacgcgc cctggaggcc ttgctcacgg atgcggggga gttgagaggt    360
ccgccgttac agttggacac aggccaactt gtgaagattg caaaacgtgg cggcgtgacc    420
gcaatggagg cagtgcatgc atcgcgcaat gcactgacgg gtgcccccct gaacctgacc    480
ccggaccaag tggtggctat cgccagcaac attggcggca agcaagcgct cgaaacggtg    540
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct    600
atcgccagca acattggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg    660
ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag caacattggc    720
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc    780
ctgaccccgg accaagtggt ggctatcgcc agcaacggtg gcggcaagca agcgctcgaa    840
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgactcc ggaccaagtg    900
gtggctatcg ccagccacga tggcggcaag caagcgctcg aaacggtgca gcggctgttg    960
ccggtgctgt gccaggacca tggcctgact ccggaccaag tggtggctat cgccagccac   1020
gatggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac   1080
catggcctga ccccggacca agtggtggct atcgccagca acattggcgg caagcaagcg   1140
ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gaccccggac   1200
caagtggtgg ctatcgccag caacaatggc ggcaagcaag cgctcgaaac ggtgcagcgg   1260
ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc   1320
agcaacggtg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc   1380
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacaa tggcggcaag   1440
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc   1500
ccggaccaag tggtggctat cgccagcaac attggcggca agcaagcgct cgaaagcatt   1560
gtggcccagc tgagccggcc tgatccggcg ttggccgcgt tgaccaacga ccacctcgtc   1620
gccttggcct gcctcggcgg acgtcctgcc atggatgcag tgaaaaaggg attgccgcac   1680
gcgccggaat tgatcagaag agtcaatcgc cgtattggcg aacgcacgtc ccatcgcgtt   1740
gcgatatcta gagtgggagg aagctctcgc agagagtcca tcaacccatg gattctgact   1800
ggtttcgctg atgccgaagg atcattcata ctagacatcc gcaaccgaaa caacgaaagc   1860
aacagatacc gaacttcgct gagattccag atcaccctgc acaacaagga caaatcgatt   1920
ctggagaata tccagtccac ttggaaggtc ggcaagatca caaacagcag tgacagagcc   1980
gtcatgctga gggtcacccg tttcgaagat ttgaaagtga ttatcgacca cttcgagaaa   2040
tatccgctga ttacccagaa attgggcgat tacaagttgt ttaaacaggc attcagcgtc   2100
atggagaata aagaacatct taaggagaat gggattaagg agctcgtacg aatcaaagct   2160
aagatgaatt ggggtctcaa tgacgaattg aaaaaagcat ttccagagaa cattagcaaa   2220
gagcgccccc ttatcaataa gaacattccg aatttcaaat ggctggctgg attcacagct   2280
ggtgaaggct acttcggcgt gaatctaaaa aaggtaaagg gcaccgcaaa ggtatacgtg   2340
ggactgagat tctcaatctc acagcacatc agagacaaga acctgatgaa ttcattgata   2400
acatacctag gctgtggttc catctgggag aagaacaagt ctgagttcag atggctcgag   2460
ttcgtcgtaa ccaaattcag cgatatcaac gacaagatca ttccggtatt ccaggaaaat   2520
actctgattg gcgtcaaact cgaggacttt gaagattggt gcaaggttgc caaattgatc   2580
aaagagaaga aacacctgac cgaatccggt ttggatgaga ttaagaaaat caagctgaac   2640
atgaacaaag gtcgtgtctt cgctagcacc ggttctgagc cacctcgggc tgagaccttt   2700
gtattcctgg acctagaagc cactgggctc ccaaacatgg accctgagat tgcagagata   2760
tccctttttg ctgttcaccg ctcttccctg gagaacccag aacgggatga ttctggttcc   2820
ttggtgctgc cccgtgttct ggacaagctc acactgtgca tgtgcccgga gcgccccttt   2880
actgccaagg ccagtgagat tactggtttg agcagcgaaa gcctgatgca ctgcgggaag   2940
gctggtttca atggcgctgt ggtaaggaca ctgcagggct tcctaagccg ccaggagggc   3000
cccatctgcc ttgtggccca caatggcttc gattatgact tcccactgct gtgcacggag   3060
ctacaacgtc tgggtgccca tctgccccaa gacactgtct gcctggacac actgcctgca   3120
ttgcggggcc tggaccgtgc tcacagccac ggcaccaggg ctcaaggccg caaaagctac   3180
agcctggcca gtctcttcca ccgctacttc caggctgaac ccagtgctgc ccattcagca   3240
gaaggtgatg tgcacaccct gcttctgatc ttcctgcatc gtgctcctga gctgctcgcc   3300
tgggcagatg agcaggcccg cagctgggct catattgagc ccatgtacgt gccacctgat   3360
ggtccaagcc tcgaagcc                                                 3378


<210>  16

<211>  1126
<212>  PRT
<213>  artificial sequence

<220>
<223>  MegaTal TCRA_S02_Trex2

<400>  16
Met Gly Ser Cys Arg Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
            20                  25                  30          


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
        35                  40                  45              


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
    50                  55                  60                  


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr 
65                  70                  75                  80  


Gln His Ile Ile Thr Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val 
                85                  90                  95      


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
            100                 105                 110         


Thr Asp Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly 
        115                 120                 125             


Gln Leu Val Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala 
    130                 135                 140                 


Val His Ala Ser Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr 
145                 150                 155                 160 


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
                165                 170                 175     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            180                 185                 190         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        195                 200                 205             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    210                 215                 220                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
225                 230                 235                 240 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                245                 250                 255     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            260                 265                 270         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        275                 280                 285             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    290                 295                 300                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
305                 310                 315                 320 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                325                 330                 335     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            340                 345                 350         


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
        355                 360                 365             


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
    370                 375                 380                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
385                 390                 395                 400 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                405                 410                 415     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
            420                 425                 430         


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
        435                 440                 445             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
    450                 455                 460                 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
465                 470                 475                 480 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
                485                 490                 495     


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
            500                 505                 510         


Gly Lys Gln Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp 
        515                 520                 525             


Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys 
    530                 535                 540                 


Leu Gly Gly Arg Pro Ala Met Asp Ala Val Lys Lys Gly Leu Pro His 
545                 550                 555                 560 


Ala Pro Glu Leu Ile Arg Arg Val Asn Arg Arg Ile Gly Glu Arg Thr 
                565                 570                 575     


Ser His Arg Val Ala Ile Ser Arg Val Gly Gly Ser Ser Arg Arg Glu 
            580                 585                 590         


Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Ser 
        595                 600                 605             


Phe Ile Leu Asp Ile Arg Asn Arg Asn Asn Glu Ser Asn Arg Tyr Arg 
    610                 615                 620                 


Thr Ser Leu Arg Phe Gln Ile Thr Leu His Asn Lys Asp Lys Ser Ile 
625                 630                 635                 640 


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Lys Ile Thr Asn Ser 
                645                 650                 655     


Ser Asp Arg Ala Val Met Leu Arg Val Thr Arg Phe Glu Asp Leu Lys 
            660                 665                 670         


Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
        675                 680                 685             


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys 
    690                 695                 700                 


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
705                 710                 715                 720 


Lys Met Asn Trp Gly Leu Asn Asp Glu Leu Lys Lys Ala Phe Pro Glu 
                725                 730                 735     


Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Phe 
            740                 745                 750         


Lys Trp Leu Ala Gly Phe Thr Ala Gly Glu Gly Tyr Phe Gly Val Asn 
        755                 760                 765             


Leu Lys Lys Val Lys Gly Thr Ala Lys Val Tyr Val Gly Leu Arg Phe 
    770                 775                 780                 


Ser Ile Ser Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
785                 790                 795                 800 


Thr Tyr Leu Gly Cys Gly Ser Ile Trp Glu Lys Asn Lys Ser Glu Phe 
                805                 810                 815     


Arg Trp Leu Glu Phe Val Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
            820                 825                 830         


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
        835                 840                 845             


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Lys Glu Lys Lys 
    850                 855                 860                 


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
865                 870                 875                 880 


Met Asn Lys Gly Arg Val Phe Ala Ser Thr Gly Ser Glu Pro Pro Arg 
                885                 890                 895     


Ala Glu Thr Phe Val Phe Leu Asp Leu Glu Ala Thr Gly Leu Pro Asn 
            900                 905                 910         


Met Asp Pro Glu Ile Ala Glu Ile Ser Leu Phe Ala Val His Arg Ser 
        915                 920                 925             


Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser Gly Ser Leu Val Leu Pro 
    930                 935                 940                 


Arg Val Leu Asp Lys Leu Thr Leu Cys Met Cys Pro Glu Arg Pro Phe 
945                 950                 955                 960 


Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu Ser Ser Glu Ser Leu Met 
                965                 970                 975     


His Cys Gly Lys Ala Gly Phe Asn Gly Ala Val Val Arg Thr Leu Gln 
            980                 985                 990         


Gly Phe Leu Ser Arg Gln Glu Gly Pro Ile Cys Leu Val Ala His Asn 
        995                 1000                1005            


Gly Phe Asp Tyr Asp Phe Pro Leu Leu Cys Thr Glu Leu Gln Arg Leu 
    1010                1015                1020                


Gly Ala His Leu Pro Gln Asp Thr Val Cys Leu Asp Thr Leu Pro Ala 
1025                1030                1035                1040


Leu Arg Gly Leu Asp Arg Ala His Ser His Gly Thr Arg Ala Gln Gly 
                1045                1050                1055    


Arg Lys Ser Tyr Ser Leu Ala Ser Leu Phe His Arg Tyr Phe Gln Ala 
            1060                1065                1070        


Glu Pro Ser Ala Ala His Ser Ala Glu Gly Asp Val His Thr Leu Leu 
        1075                1080                1085            


Leu Ile Phe Leu His Arg Ala Pro Glu Leu Leu Ala Trp Ala Asp Glu 
    1090                1095                1100                


Gln Ala Arg Ser Trp Ala His Ile Glu Pro Met Tyr Val Pro Pro Asp 
1105                1110                1115                1120


Gly Pro Ser Leu Glu Ala 
                1125    




   

