                         SEQUENCE LISTING

<110>  INSERM
 
<120>  Hydrophobically modified antisense oligonucleotides comprising a 
       cetal group

<130>  BET13P1376

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Ile Tyr Arg Asp Leu Ile Ser His Asp Glu Met Phe Ser Asp 
1               5                   10                  15      


Ile Tyr Lys Ile Arg Glu Ile Ala Asp Gly Leu Cys Leu Glu Val Glu 
            20                  25                  30          


Gly Lys Met Val Ser Arg Thr Glu Gly Asn Ile Asp Asp Ser Leu Ile 
        35                  40                  45              


Gly Gly Asn Ala Ser Ala Glu Gly Pro Glu Gly Glu Gly Thr Glu Ser 
    50                  55                  60                  


Thr Val Ile Thr Gly Val Asp Ile Val Met Asn His His Leu Gln Glu 
65                  70                  75                  80  


Thr Ser Phe Thr Lys Glu Ala Tyr Lys Lys Tyr Ile Lys Asp Tyr Met 
                85                  90                  95      


Lys Ser Ile Lys Gly Lys Leu Glu Glu Gln Arg Pro Glu Arg Val Lys 
            100                 105                 110         


Pro Phe Met Thr Gly Ala Ala Glu Gln Ile Lys His Ile Leu Ala Asn 
        115                 120                 125             


Phe Lys Asn Tyr Gln Phe Phe Ile Gly Glu Asn Met Asn Pro Asp Gly 
    130                 135                 140                 


Met Val Ala Leu Leu Asp Tyr Arg Glu Asp Gly Val Thr Pro Tyr Met 
145                 150                 155                 160 


Ile Phe Phe Lys Asp Gly Leu Glu Met Glu Lys Cys 
                165                 170         


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  2
accaatgagc gagtcatcaa                                                   20


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting TCTP

<400>  3
aacccguccg cgaucucccg g                                                 21


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scrambled oligonucleotide

<400>  4
cgtgtaggta cggcagatc                                                    19


<210>  5
<211>  829
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (153)..(173)
<223>  Region targeted by the siRNA of SEQ ID NO: 3

<220>
<221>  misc_feature
<222>  (221)..(240)
<223>  Region targeted by the antisense oligonucleotide of SEQ ID NO: 2

<400>  5
ccccccgagc gccgctccgg ctgcaccgcg ctcgctccga gtttcaggct cgtgctaagc       60

tagcgccgtc gtcgtctccc ttcagtcgcc atcatgatta tctaccggga cctcatcagc      120

cacgatgaga tgttctccga catctacaag atccgggaga tcgcggacgg gttgtgcctg      180

gaggtggagg ggaagatggt cagtaggaca gaaggtaaca ttgatgactc gctcattggt      240

ggaaatgcct ccgctgaagg ccccgagggc gaaggtaccg aaagcacagt aatcactggt      300

gtcgatattg tcatgaacca tcacctgcag gaaacaagtt tcacaaaaga agcctacaag      360

aagtacatca aagattacat gaaatcaatc aaagggaaac ttgaagaaca gagaccagaa      420

agagtaaaac cttttatgac aggggctgca gaacaaatca agcacatcct tgctaatttc      480

aaaaactacc agttctttat tggtgaaaac atgaatccag atggcatggt tgctctattg      540

gactaccgtg aggatggtgt gaccccatat atgattttct ttaaggatgg tttagaaatg      600

gaaaaatgtt aacaaatgtg gcaattattt tggatctatc acctgtcatc ataactggct      660

tctgcttgtc atccacacaa caccaggact taagacaaat gggactgatg tcatcttgag      720

ctcttcattt attttgactg tgatttattt ggagtggagg cattgttttt aagaaaaaca      780

tgtcatgtag gttgtctaaa aataaaatgc atttaaactc atttgagag                  829


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Region targeted by the antisense oligonucleotide of SEQ ID NO: 2

<400>  6
aacttgtttc ctgcaggtga                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   Antisense oligonucleotide targeting TCTP

<400>  7
tggttcatga caatatcgac                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  8
taatcatgat ggcgactgaa                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  9
gctgatgagg tcccggtaga                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  10
tcggagaaca tctcatcgtg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  11
caggcacaac ccgtccgcga                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  12
accatcttcc cctccacctc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  13
tgttaccttc tgtcctactg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  14
ccttcagcgg aggcatttcc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  15
cagtaccttc gccctcgggg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  16
accagtgatt actgtgcttt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  17
cttgtaggct tcttttgtga                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  18
atgtaatctt tgatgtactt                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  19
gtttcccttt gattgatttc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  20
ttctggtctc tgttcttcaa                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  21
ataaagaact ggtagttttt                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  22
ctggattcat gttttcacca                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  23
caatagagca accatgccat                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  24
acaccatcct cacggtagtc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  25
agaaaatcat atatggggtc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  26
catttctaaa ccatccttaa                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  27
ttaacatttc tccatttcta                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  28
tctcccggat cttgtagatg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  29
gtcataaaag gttttactct                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  30
tgatttgttc tgcagcccct                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide targeting TCTP

<400>  31
gaaattagca aggatgtgct                                                   20


<210>  32
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dA15

<400>  32
aaaaaaaaaa aaaaa                                                        15


<210>  33
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dT15

<400>  33
tttttttttt ttttt                                                        15


<210>  34
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  control non complementary ss-DNA

<400>  34
ggctcacaac aggc                                                         14


