                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
     
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER

<130>  23529-US-PCT

<150>  US 61/831,344
<151>  2013-06-05

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  2735
<212>  DNA
<213>  Homo sapiens 

<220>
<223>  CD86 Variant 1

<400>  1
agtcattgcc gaggaaggct tgcacagggt gaaagctttg cttctctgct gctgtaacag       60

ggactagcac agacacacgg atgagtgggg tcatttccag atattaggtc acagcagaag      120

cagccaaaat ggatccccag tgcactatgg gactgagtaa cattctcttt gtgatggcct      180

tcctgctctc tggtgctgct cctctgaaga ttcaagctta tttcaatgag actgcagacc      240

tgccatgcca atttgcaaac tctcaaaacc aaagcctgag tgagctagta gtattttggc      300

aggaccagga aaacttggtt ctgaatgagg tatacttagg caaagagaaa tttgacagtg      360

ttcattccaa gtatatgggc cgcacaagtt ttgattcgga cagttggacc ctgagacttc      420

acaatcttca gatcaaggac aagggcttgt atcaatgtat catccatcac aaaaagccca      480

caggaatgat tcgcatccac cagatgaatt ctgaactgtc agtgcttgct aacttcagtc      540

aacctgaaat agtaccaatt tctaatataa cagaaaatgt gtacataaat ttgacctgct      600

catctataca cggttaccca gaacctaaga agatgagtgt tttgctaaga accaagaatt      660

caactatcga gtatgatggt attatgcaga aatctcaaga taatgtcaca gaactgtacg      720

acgtttccat cagcttgtct gtttcattcc ctgatgttac gagcaatatg accatcttct      780

gtattctgga aactgacaag acgcggcttt tatcttcacc tttctctata gagcttgagg      840

accctcagcc tcccccagac cacattcctt ggattacagc tgtacttcca acagttatta      900

tatgtgtgat ggttttctgt ctaattctat ggaaatggaa gaagaagaag cggcctcgca      960

actcttataa atgtggaacc aacacaatgg agagggaaga gagtgaacag accaagaaaa     1020

gagaaaaaat ccatatacct gaaagatctg atgaagccca gcgtgttttt aaaagttcga     1080

agacatcttc atgcgacaaa agtgatacat gtttttaatt aaagagtaaa gcccatacaa     1140

gtattcattt tttctaccct ttcctttgta agttcctggg caaccttttt gatttcttcc     1200

agaaggcaaa aagacattac catgagtaat aagggggctc caggactccc tctaagtgga     1260

atagcctccc tgtaactcca gctctgctcc gtatgccaag aggagacttt aattctctta     1320

ctgcttcttt tcacttcaga gcacacttat gggccaagcc cagcttaatg gctcatgacc     1380

tggaaataaa atttaggacc aatacctcct ccagatcaga ttcttctctt aatttcatag     1440

attgtgtttt ttttttaaat agacctctca atttctggaa aactgccttt tatctgccca     1500

gaattctaag ctggtgcccc actgaatttt gtgtacctgt gactaaacaa ctacctcctc     1560

agtctgggtg ggacttatgt atttatgacc ttatagtgtt aatatcttga aacatagaga     1620

tctatgtact gtaatagtgt gattactatg ctctagagaa aagtctaccc ctgctaagga     1680

gttctcatcc ctctgtcagg gtcagtaagg aaaacggtgg cctagggtac aggcaacaat     1740

gagcagacca acctaaattt ggggaaatta ggagaggcag agatagaacc tggagccact     1800

tctatctggg ctgttgctaa tattgaggag gcttgcccca cccaacaagc catagtggag     1860

agaactgaat aaacaggaaa atgccagagc ttgtgaaccc tgtttctctt gaagaactga     1920

ctagtgagat ggcctgggga agctgtgaaa gaaccaaaag agatcacaat actcaaaaga     1980

gagagagaga gaaaaaagag agatcttgat ccacagaaat acatgaaatg tctggtctgt     2040

ccaccccatc aacaagtctt gaaacaagca acagatggat agtctgtcca aatggacata     2100

agacagacag cagtttccct ggtggtcagg gaggggtttt ggtgataccc aagttattgg     2160

gatgtcatct tcctggaagc agagctgggg agggagagcc atcaccttga taatgggatg     2220

aatggaagga ggcttaggac tttccactcc tggctgagag aggaagagct gcaacggaat     2280

taggaagacc aagacacaga tcacccgggg cttacttagc ctacagatgt cctacgggaa     2340

cgtgggctgg cccagcatag ggctagcaaa tttgagttgg atgattgttt ttgctcaagg     2400

caaccagagg aaacttgcat acagagacag atatactggg agaaatgact ttgaaaacct     2460

ggctctaagg tgggatcact aagggatggg gcagtctctg cccaaacata aagagaactc     2520

tggggagcct gagccacaaa aatgttcctt tattttatgt aaaccctcaa gggttataga     2580

ctgccatgct agacaagctt gtccatgtaa tattcccatg tttttaccct gcccctgcct     2640

tgattagact cctagcacct ggctagtttc taacatgttt tgtgcagcac agtttttaat     2700

aaatgcttgt tacattcatt taaaaaaaaa aaaaa                                2735


<210>  2
<211>  323
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD86 Variant 1

<400>  2

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
                245                 250                 255     


Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn 
            260                 265                 270         


Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
        275                 280                 285             


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
    290                 295                 300                 


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
305                 310                 315                 320 


Thr Cys Phe 
            


<210>  3
<211>  2790
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CD86 Variant 2

<400>  3
ccctttctgt atttgagttc taccgtcagt cctggcatta tttctctctc tacaaggagc       60

cttaggaggt acggggagct cgcaaatact ccttttggtt tattcttacc accttgcttc      120

tgtgttcctt gggaatgctg ctgtgcttat gcatctggtc tctttttgga gctacagtgg      180

acaggcattt gtgacagcac tatgggactg agtaacattc tctttgtgat ggccttcctg      240

ctctctggtg ctgctcctct gaagattcaa gcttatttca atgagactgc agacctgcca      300

tgccaatttg caaactctca aaaccaaagc ctgagtgagc tagtagtatt ttggcaggac      360

caggaaaact tggttctgaa tgaggtatac ttaggcaaag agaaatttga cagtgttcat      420

tccaagtata tgggccgcac aagttttgat tcggacagtt ggaccctgag acttcacaat      480

cttcagatca aggacaaggg cttgtatcaa tgtatcatcc atcacaaaaa gcccacagga      540

atgattcgca tccaccagat gaattctgaa ctgtcagtgc ttgctaactt cagtcaacct      600

gaaatagtac caatttctaa tataacagaa aatgtgtaca taaatttgac ctgctcatct      660

atacacggtt acccagaacc taagaagatg agtgttttgc taagaaccaa gaattcaact      720

atcgagtatg atggtattat gcagaaatct caagataatg tcacagaact gtacgacgtt      780

tccatcagct tgtctgtttc attccctgat gttacgagca atatgaccat cttctgtatt      840

ctggaaactg acaagacgcg gcttttatct tcacctttct ctatagagct tgaggaccct      900

cagcctcccc cagaccacat tccttggatt acagctgtac ttccaacagt tattatatgt      960

gtgatggttt tctgtctaat tctatggaaa tggaagaaga agaagcggcc tcgcaactct     1020

tataaatgtg gaaccaacac aatggagagg gaagagagtg aacagaccaa gaaaagagaa     1080

aaaatccata tacctgaaag atctgatgaa gcccagcgtg tttttaaaag ttcgaagaca     1140

tcttcatgcg acaaaagtga tacatgtttt taattaaaga gtaaagccca tacaagtatt     1200

cattttttct accctttcct ttgtaagttc ctgggcaacc tttttgattt cttccagaag     1260

gcaaaaagac attaccatga gtaataaggg ggctccagga ctccctctaa gtggaatagc     1320

ctccctgtaa ctccagctct gctccgtatg ccaagaggag actttaattc tcttactgct     1380

tcttttcact tcagagcaca cttatgggcc aagcccagct taatggctca tgacctggaa     1440

ataaaattta ggaccaatac ctcctccaga tcagattctt ctcttaattt catagattgt     1500

gttttttttt taaatagacc tctcaatttc tggaaaactg ccttttatct gcccagaatt     1560

ctaagctggt gccccactga attttgtgta cctgtgacta aacaactacc tcctcagtct     1620

gggtgggact tatgtattta tgaccttata gtgttaatat cttgaaacat agagatctat     1680

gtactgtaat agtgtgatta ctatgctcta gagaaaagtc tacccctgct aaggagttct     1740

catccctctg tcagggtcag taaggaaaac ggtggcctag ggtacaggca acaatgagca     1800

gaccaaccta aatttgggga aattaggaga ggcagagata gaacctggag ccacttctat     1860

ctgggctgtt gctaatattg aggaggcttg ccccacccaa caagccatag tggagagaac     1920

tgaataaaca ggaaaatgcc agagcttgtg aaccctgttt ctcttgaaga actgactagt     1980

gagatggcct ggggaagctg tgaaagaacc aaaagagatc acaatactca aaagagagag     2040

agagagaaaa aagagagatc ttgatccaca gaaatacatg aaatgtctgg tctgtccacc     2100

ccatcaacaa gtcttgaaac aagcaacaga tggatagtct gtccaaatgg acataagaca     2160

gacagcagtt tccctggtgg tcagggaggg gttttggtga tacccaagtt attgggatgt     2220

catcttcctg gaagcagagc tggggaggga gagccatcac cttgataatg ggatgaatgg     2280

aaggaggctt aggactttcc actcctggct gagagaggaa gagctgcaac ggaattagga     2340

agaccaagac acagatcacc cggggcttac ttagcctaca gatgtcctac gggaacgtgg     2400

gctggcccag catagggcta gcaaatttga gttggatgat tgtttttgct caaggcaacc     2460

agaggaaact tgcatacaga gacagatata ctgggagaaa tgactttgaa aacctggctc     2520

taaggtggga tcactaaggg atggggcagt ctctgcccaa acataaagag aactctgggg     2580

agcctgagcc acaaaaatgt tcctttattt tatgtaaacc ctcaagggtt atagactgcc     2640

atgctagaca agcttgtcca tgtaatattc ccatgttttt accctgcccc tgccttgatt     2700

agactcctag cacctggcta gtttctaaca tgttttgtgc agcacagttt ttaataaatg     2760

cttgttacat tcatttaaaa aaaaaaaaaa                                      2790


<210>  4
<211>  2790
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CD86 Variant 2

<400>  4
ccctttctgt atttgagttc taccgtcagt cctggcatta tttctctctc tacaaggagc       60

cttaggaggt acggggagct cgcaaatact ccttttggtt tattcttacc accttgcttc      120

tgtgttcctt gggaatgctg ctgtgcttat gcatctggtc tctttttgga gctacagtgg      180

acaggcattt gtgacagcac tatgggactg agtaacattc tctttgtgat ggccttcctg      240

ctctctggtg ctgctcctct gaagattcaa gcttatttca atgagactgc agacctgcca      300

tgccaatttg caaactctca aaaccaaagc ctgagtgagc tagtagtatt ttggcaggac      360

caggaaaact tggttctgaa tgaggtatac ttaggcaaag agaaatttga cagtgttcat      420

tccaagtata tgggccgcac aagttttgat tcggacagtt ggaccctgag acttcacaat      480

cttcagatca aggacaaggg cttgtatcaa tgtatcatcc atcacaaaaa gcccacagga      540

atgattcgca tccaccagat gaattctgaa ctgtcagtgc ttgctaactt cagtcaacct      600

gaaatagtac caatttctaa tataacagaa aatgtgtaca taaatttgac ctgctcatct      660

atacacggtt acccagaacc taagaagatg agtgttttgc taagaaccaa gaattcaact      720

atcgagtatg atggtattat gcagaaatct caagataatg tcacagaact gtacgacgtt      780

tccatcagct tgtctgtttc attccctgat gttacgagca atatgaccat cttctgtatt      840

ctggaaactg acaagacgcg gcttttatct tcacctttct ctatagagct tgaggaccct      900

cagcctcccc cagaccacat tccttggatt acagctgtac ttccaacagt tattatatgt      960

gtgatggttt tctgtctaat tctatggaaa tggaagaaga agaagcggcc tcgcaactct     1020

tataaatgtg gaaccaacac aatggagagg gaagagagtg aacagaccaa gaaaagagaa     1080

aaaatccata tacctgaaag atctgatgaa gcccagcgtg tttttaaaag ttcgaagaca     1140

tcttcatgcg acaaaagtga tacatgtttt taattaaaga gtaaagccca tacaagtatt     1200

cattttttct accctttcct ttgtaagttc ctgggcaacc tttttgattt cttccagaag     1260

gcaaaaagac attaccatga gtaataaggg ggctccagga ctccctctaa gtggaatagc     1320

ctccctgtaa ctccagctct gctccgtatg ccaagaggag actttaattc tcttactgct     1380

tcttttcact tcagagcaca cttatgggcc aagcccagct taatggctca tgacctggaa     1440

ataaaattta ggaccaatac ctcctccaga tcagattctt ctcttaattt catagattgt     1500

gttttttttt taaatagacc tctcaatttc tggaaaactg ccttttatct gcccagaatt     1560

ctaagctggt gccccactga attttgtgta cctgtgacta aacaactacc tcctcagtct     1620

gggtgggact tatgtattta tgaccttata gtgttaatat cttgaaacat agagatctat     1680

gtactgtaat agtgtgatta ctatgctcta gagaaaagtc tacccctgct aaggagttct     1740

catccctctg tcagggtcag taaggaaaac ggtggcctag ggtacaggca acaatgagca     1800

gaccaaccta aatttgggga aattaggaga ggcagagata gaacctggag ccacttctat     1860

ctgggctgtt gctaatattg aggaggcttg ccccacccaa caagccatag tggagagaac     1920

tgaataaaca ggaaaatgcc agagcttgtg aaccctgttt ctcttgaaga actgactagt     1980

gagatggcct ggggaagctg tgaaagaacc aaaagagatc acaatactca aaagagagag     2040

agagagaaaa aagagagatc ttgatccaca gaaatacatg aaatgtctgg tctgtccacc     2100

ccatcaacaa gtcttgaaac aagcaacaga tggatagtct gtccaaatgg acataagaca     2160

gacagcagtt tccctggtgg tcagggaggg gttttggtga tacccaagtt attgggatgt     2220

catcttcctg gaagcagagc tggggaggga gagccatcac cttgataatg ggatgaatgg     2280

aaggaggctt aggactttcc actcctggct gagagaggaa gagctgcaac ggaattagga     2340

agaccaagac acagatcacc cggggcttac ttagcctaca gatgtcctac gggaacgtgg     2400

gctggcccag catagggcta gcaaatttga gttggatgat tgtttttgct caaggcaacc     2460

agaggaaact tgcatacaga gacagatata ctgggagaaa tgactttgaa aacctggctc     2520

taaggtggga tcactaaggg atggggcagt ctctgcccaa acataaagag aactctgggg     2580

agcctgagcc acaaaaatgt tcctttattt tatgtaaacc ctcaagggtt atagactgcc     2640

atgctagaca agcttgtcca tgtaatattc ccatgttttt accctgcccc tgccttgatt     2700

agactcctag cacctggcta gtttctaaca tgttttgtgc agcacagttt ttaataaatg     2760

cttgttacat tcatttaaaa aaaaaaaaaa                                      2790


<210>  5
<211>  2646
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CD86 Variant 3

<400>  5
ccctttctgt atttgagttc taccgtcagt cctggcatta tttctctctc tacaaggagc       60

cttaggaggt acggggagct cgcaaatact ccttttggtt tattcttacc accttgcttc      120

tgtgttcctt gggaatgctg ctgtgcttat gcatctggtc tctttttgga gctacagtgg      180

acaggcattt gtgacagcac tatgggactg agtaacattc tctttgtgat ggccttcctg      240

ctctctggtg ctgctcctct gaagattcaa gcttatttca atgagactgc agacctgcca      300

tgccaatttg caaactctca aaaccaaagc ctgagtgagc tagtagtatt ttggcaggac      360

caggaaaact tggttctgaa tgaggtatac ttaggcaaag agaaatttga cagtgttcat      420

tccaagtata tgggccgcac aagttttgat tcggacagtt ggaccctgag acttcacaat      480

cttcagatca aggacaaggg cttgtatcaa tgtatcatcc atcacaaaaa gcccacagga      540

atgattcgca tccaccagat gaattctgaa ctgtcagtgc ttgctaactt cagtcaacct      600

gaaatagtac caatttctaa tataacagaa aatgtgtaca taaatttgac ctgctcatct      660

atacacggtt acccagaacc taagaagatg agtgttttgc taagaaccaa gaattcaact      720

atcgagtatg atggtattat gcagaaatct caagataatg tcacagaact gtacgacgtt      780

tccatcagct tgtctgtttc attccctgat gttacgagca atatgaccat cttctgtatt      840

ctggaaactg acaagacgcg gcttttatct tcacctttct ctataggaac caacacaatg      900

gagagggaag agagtgaaca gaccaagaaa agagaaaaaa tccatatacc tgaaagatct      960

gatgaagccc agcgtgtttt taaaagttcg aagacatctt catgcgacaa aagtgataca     1020

tgtttttaat taaagagtaa agcccataca agtattcatt ttttctaccc tttcctttgt     1080

aagttcctgg gcaacctttt tgatttcttc cagaaggcaa aaagacatta ccatgagtaa     1140

taagggggct ccaggactcc ctctaagtgg aatagcctcc ctgtaactcc agctctgctc     1200

cgtatgccaa gaggagactt taattctctt actgcttctt ttcacttcag agcacactta     1260

tgggccaagc ccagcttaat ggctcatgac ctggaaataa aatttaggac caatacctcc     1320

tccagatcag attcttctct taatttcata gattgtgttt tttttttaaa tagacctctc     1380

aatttctgga aaactgcctt ttatctgccc agaattctaa gctggtgccc cactgaattt     1440

tgtgtacctg tgactaaaca actacctcct cagtctgggt gggacttatg tatttatgac     1500

cttatagtgt taatatcttg aaacatagag atctatgtac tgtaatagtg tgattactat     1560

gctctagaga aaagtctacc cctgctaagg agttctcatc cctctgtcag ggtcagtaag     1620

gaaaacggtg gcctagggta caggcaacaa tgagcagacc aacctaaatt tggggaaatt     1680

aggagaggca gagatagaac ctggagccac ttctatctgg gctgttgcta atattgagga     1740

ggcttgcccc acccaacaag ccatagtgga gagaactgaa taaacaggaa aatgccagag     1800

cttgtgaacc ctgtttctct tgaagaactg actagtgaga tggcctgggg aagctgtgaa     1860

agaaccaaaa gagatcacaa tactcaaaag agagagagag agaaaaaaga gagatcttga     1920

tccacagaaa tacatgaaat gtctggtctg tccaccccat caacaagtct tgaaacaagc     1980

aacagatgga tagtctgtcc aaatggacat aagacagaca gcagtttccc tggtggtcag     2040

ggaggggttt tggtgatacc caagttattg ggatgtcatc ttcctggaag cagagctggg     2100

gagggagagc catcaccttg ataatgggat gaatggaagg aggcttagga ctttccactc     2160

ctggctgaga gaggaagagc tgcaacggaa ttaggaagac caagacacag atcacccggg     2220

gcttacttag cctacagatg tcctacggga acgtgggctg gcccagcata gggctagcaa     2280

atttgagttg gatgattgtt tttgctcaag gcaaccagag gaaacttgca tacagagaca     2340

gatatactgg gagaaatgac tttgaaaacc tggctctaag gtgggatcac taagggatgg     2400

ggcagtctct gcccaaacat aaagagaact ctggggagcc tgagccacaa aaatgttcct     2460

ttattttatg taaaccctca agggttatag actgccatgc tagacaagct tgtccatgta     2520

atattcccat gtttttaccc tgcccctgcc ttgattagac tcctagcacc tggctagttt     2580

ctaacatgtt ttgtgcagca cagtttttaa taaatgcttg ttacattcat ttaaaaaaaa     2640

aaaaaa                                                                2646


<210>  6
<211>  275
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD86 Variant 3

<400>  6

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
225                 230                 235                 240 


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
                245                 250                 255     


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
            260                 265                 270         


Thr Cys Phe 
        275 


<210>  7
<211>  2399
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CD86 Variant 4

<400>  7
agtcattgcc gaggaaggct tgcacagggt gaaagctttg cttctctgct gctgtaacag       60

ggactagcac agacacacgg atgagtgggg tcatttccag atattaggtc acagcagaag      120

cagccaaaat ggatccccag tgcactatgg gactgagtaa cattctcttt gtgatggcct      180

tcctgctctc tgctaacttc agtcaacctg aaatagtacc aatttctaat ataacagaaa      240

atgtgtacat aaatttgacc tgctcatcta tacacggtta cccagaacct aagaagatga      300

gtgttttgct aagaaccaag aattcaacta tcgagtatga tggtattatg cagaaatctc      360

aagataatgt cacagaactg tacgacgttt ccatcagctt gtctgtttca ttccctgatg      420

ttacgagcaa tatgaccatc ttctgtattc tggaaactga caagacgcgg cttttatctt      480

cacctttctc tatagagctt gaggaccctc agcctccccc agaccacatt ccttggatta      540

cagctgtact tccaacagtt attatatgtg tgatggtttt ctgtctaatt ctatggaaat      600

ggaagaagaa gaagcggcct cgcaactctt ataaatgtgg aaccaacaca atggagaggg      660

aagagagtga acagaccaag aaaagagaaa aaatccatat acctgaaaga tctgatgaag      720

cccagcgtgt ttttaaaagt tcgaagacat cttcatgcga caaaagtgat acatgttttt      780

aattaaagag taaagcccat acaagtattc attttttcta ccctttcctt tgtaagttcc      840

tgggcaacct ttttgatttc ttccagaagg caaaaagaca ttaccatgag taataagggg      900

gctccaggac tccctctaag tggaatagcc tccctgtaac tccagctctg ctccgtatgc      960

caagaggaga ctttaattct cttactgctt cttttcactt cagagcacac ttatgggcca     1020

agcccagctt aatggctcat gacctggaaa taaaatttag gaccaatacc tcctccagat     1080

cagattcttc tcttaatttc atagattgtg tttttttttt aaatagacct ctcaatttct     1140

ggaaaactgc cttttatctg cccagaattc taagctggtg ccccactgaa ttttgtgtac     1200

ctgtgactaa acaactacct cctcagtctg ggtgggactt atgtatttat gaccttatag     1260

tgttaatatc ttgaaacata gagatctatg tactgtaata gtgtgattac tatgctctag     1320

agaaaagtct acccctgcta aggagttctc atccctctgt cagggtcagt aaggaaaacg     1380

gtggcctagg gtacaggcaa caatgagcag accaacctaa atttggggaa attaggagag     1440

gcagagatag aacctggagc cacttctatc tgggctgttg ctaatattga ggaggcttgc     1500

cccacccaac aagccatagt ggagagaact gaataaacag gaaaatgcca gagcttgtga     1560

accctgtttc tcttgaagaa ctgactagtg agatggcctg gggaagctgt gaaagaacca     1620

aaagagatca caatactcaa aagagagaga gagagaaaaa agagagatct tgatccacag     1680

aaatacatga aatgtctggt ctgtccaccc catcaacaag tcttgaaaca agcaacagat     1740

ggatagtctg tccaaatgga cataagacag acagcagttt ccctggtggt cagggagggg     1800

ttttggtgat acccaagtta ttgggatgtc atcttcctgg aagcagagct ggggagggag     1860

agccatcacc ttgataatgg gatgaatgga aggaggctta ggactttcca ctcctggctg     1920

agagaggaag agctgcaacg gaattaggaa gaccaagaca cagatcaccc ggggcttact     1980

tagcctacag atgtcctacg ggaacgtggg ctggcccagc atagggctag caaatttgag     2040

ttggatgatt gtttttgctc aaggcaacca gaggaaactt gcatacagag acagatatac     2100

tgggagaaat gactttgaaa acctggctct aaggtgggat cactaaggga tggggcagtc     2160

tctgcccaaa cataaagaga actctgggga gcctgagcca caaaaatgtt cctttatttt     2220

atgtaaaccc tcaagggtta tagactgcca tgctagacaa gcttgtccat gtaatattcc     2280

catgttttta ccctgcccct gccttgatta gactcctagc acctggctag tttctaacat     2340

gttttgtgca gcacagtttt taataaatgc ttgttacatt catttaaaaa aaaaaaaaa      2399


<210>  8
<211>  217
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD86 Variant 4

<400>  8

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
            20                  25                  30          


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
        35                  40                  45              


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
    50                  55                  60                  


Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
65                  70                  75                  80  


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
                85                  90                  95      


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
            100                 105                 110         


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
        115                 120                 125             


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
    130                 135                 140                 


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
145                 150                 155                 160 


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
                165                 170                 175     


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
            180                 185                 190         


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
        195                 200                 205             


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    210                 215         


<210>  9
<211>  2685
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CD86 Variant 5

<400>  9
agtcattgcc gaggaaggct tgcacagggt gaaagctttg cttctctgct gctgtaacag       60

ggactagcac agacacacgg atgagtgggg tcatttccag atattaggtc acagcagaag      120

cagccaaaat ggatccccag tggtgctgct cctctgaaga ttcaagctta tttcaatgag      180

actgcagacc tgccatgcca atttgcaaac tctcaaaacc aaagcctgag tgagctagta      240

gtattttggc aggaccagga aaacttggtt ctgaatgagg tatacttagg caaagagaaa      300

tttgacagtg ttcattccaa gtatatgggc cgcacaagtt ttgattcgga cagttggacc      360

ctgagacttc acaatcttca gatcaaggac aagggcttgt atcaatgtat catccatcac      420

aaaaagccca caggaatgat tcgcatccac cagatgaatt ctgaactgtc agtgcttgct      480

aacttcagtc aacctgaaat agtaccaatt tctaatataa cagaaaatgt gtacataaat      540

ttgacctgct catctataca cggttaccca gaacctaaga agatgagtgt tttgctaaga      600

accaagaatt caactatcga gtatgatggt attatgcaga aatctcaaga taatgtcaca      660

gaactgtacg acgtttccat cagcttgtct gtttcattcc ctgatgttac gagcaatatg      720

accatcttct gtattctgga aactgacaag acgcggcttt tatcttcacc tttctctata      780

gagcttgagg accctcagcc tcccccagac cacattcctt ggattacagc tgtacttcca      840

acagttatta tatgtgtgat ggttttctgt ctaattctat ggaaatggaa gaagaagaag      900

cggcctcgca actcttataa atgtggaacc aacacaatgg agagggaaga gagtgaacag      960

accaagaaaa gagaaaaaat ccatatacct gaaagatctg atgaagccca gcgtgttttt     1020

aaaagttcga agacatcttc atgcgacaaa agtgatacat gtttttaatt aaagagtaaa     1080

gcccatacaa gtattcattt tttctaccct ttcctttgta agttcctggg caaccttttt     1140

gatttcttcc agaaggcaaa aagacattac catgagtaat aagggggctc caggactccc     1200

tctaagtgga atagcctccc tgtaactcca gctctgctcc gtatgccaag aggagacttt     1260

aattctctta ctgcttcttt tcacttcaga gcacacttat gggccaagcc cagcttaatg     1320

gctcatgacc tggaaataaa atttaggacc aatacctcct ccagatcaga ttcttctctt     1380

aatttcatag attgtgtttt ttttttaaat agacctctca atttctggaa aactgccttt     1440

tatctgccca gaattctaag ctggtgcccc actgaatttt gtgtacctgt gactaaacaa     1500

ctacctcctc agtctgggtg ggacttatgt atttatgacc ttatagtgtt aatatcttga     1560

aacatagaga tctatgtact gtaatagtgt gattactatg ctctagagaa aagtctaccc     1620

ctgctaagga gttctcatcc ctctgtcagg gtcagtaagg aaaacggtgg cctagggtac     1680

aggcaacaat gagcagacca acctaaattt ggggaaatta ggagaggcag agatagaacc     1740

tggagccact tctatctggg ctgttgctaa tattgaggag gcttgcccca cccaacaagc     1800

catagtggag agaactgaat aaacaggaaa atgccagagc ttgtgaaccc tgtttctctt     1860

gaagaactga ctagtgagat ggcctgggga agctgtgaaa gaaccaaaag agatcacaat     1920

actcaaaaga gagagagaga gaaaaaagag agatcttgat ccacagaaat acatgaaatg     1980

tctggtctgt ccaccccatc aacaagtctt gaaacaagca acagatggat agtctgtcca     2040

aatggacata agacagacag cagtttccct ggtggtcagg gaggggtttt ggtgataccc     2100

aagttattgg gatgtcatct tcctggaagc agagctgggg agggagagcc atcaccttga     2160

taatgggatg aatggaagga ggcttaggac tttccactcc tggctgagag aggaagagct     2220

gcaacggaat taggaagacc aagacacaga tcacccgggg cttacttagc ctacagatgt     2280

cctacgggaa cgtgggctgg cccagcatag ggctagcaaa tttgagttgg atgattgttt     2340

ttgctcaagg caaccagagg aaacttgcat acagagacag atatactggg agaaatgact     2400

ttgaaaacct ggctctaagg tgggatcact aagggatggg gcagtctctg cccaaacata     2460

aagagaactc tggggagcct gagccacaaa aatgttcctt tattttatgt aaaccctcaa     2520

gggttataga ctgccatgct agacaagctt gtccatgtaa tattcccatg tttttaccct     2580

gcccctgcct tgattagact cctagcacct ggctagtttc taacatgttt tgtgcagcac     2640

agtttttaat aaatgcttgt tacattcatt taaaaaaaaa aaaaa                     2685


<210>  10
<211>  247
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD86 Variant 5

<400>  10

Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His 
1               5                   10                  15      


Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His 
            20                  25                  30          


Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu 
        35                  40                  45              


Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn 
    50                  55                  60                  


Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly 
65                  70                  75                  80  


Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser 
                85                  90                  95      


Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr 
            100                 105                 110         


Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
        115                 120                 125             


Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg 
    130                 135                 140                 


Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro 
145                 150                 155                 160 


Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile 
                165                 170                 175     


Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys 
            180                 185                 190         


Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu 
        195                 200                 205             


Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg 
    210                 215                 220                 


Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys 
225                 230                 235                 240 


Asp Lys Ser Asp Thr Cys Phe 
                245         


