                               SEQUENCE LISTING

<110> SERPIN PHARMA, LLC
 
<120> PEPTIDE THERAPY FOR TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY 
      AND ASSOCIATED PATHOLOGIES

<130> 065292-078161-PCT

<140>
<141>

<150> 61/831,832
<151> 2013-06-06

<160> 57    

<170> PatentIn version 3.5

<210> 1
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1
Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Val or Leu

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Val, Leu or Met

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Met, Ile or Val

<220>
<221> MOD_RES
<222> (12)..(16)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 2
Xaa Xaa Phe Asn Lys Pro Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Gln 
    


<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Val or Leu

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Lys or Arg

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Val, Leu or Met

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Met, Ile or Val

<220>
<221> MOD_RES
<222> (12)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Lys or Gln

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 3
Xaa Xaa Phe Asn Xaa Pro Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210> 4
<211> 8
<212> PRT
<213> Homo sapiens

<400> 4
Arg Phe Asn Arg Pro Phe Leu Arg 
1               5               


<210> 5
<211> 8
<212> PRT
<213> Homo sapiens

<400> 5
Arg Phe Asn Lys Pro Phe Leu Arg 
1               5               


<210> 6
<211> 28
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(10)
<223> Any basic amino acid and this region may encompass 1, 2, 3, 4,
      5, 6, 7, 8, 9, 10 or between 1 and 3, between 1 and 5, between
      1 and 6, between 1 and 7, between 1 and 8, between 1 and 9, or 
      between 1 and 10 basic amino acids 

<220>
<221> MOD_RES
<222> (19)..(28)
<223> Any basic amino acid and this region may encompass 1, 2, 3, 4,
      5, 6, 7, 8, 9, 10 or between 1 and 3, between 1 and 5, between
      1 and 6, between 1 and 7, between 1 and 8, between 1 and 9, or 
      between 1 and 10 basic amino acids 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 6
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Asn Arg Pro Phe 
1               5                   10                  15      


Leu Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25              


<210> 7
<211> 28
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(10)
<223> Any basic amino acid and this region may encompass 1, 2, 3, 4,
      5, 6, 7, 8, 9, 10 or between 1 and 3, between 1 and 5, between
      1 and 6, between 1 and 7, between 1 and 8, between 1 and 9, or 
      between 1 and 10 basic amino acids 

<220>
<221> MOD_RES
<222> (19)..(28)
<223> Any basic amino acid and this region may encompass 1, 2, 3, 4,
      5, 6, 7, 8, 9, 10 or between 1 and 3, between 1 and 5, between
      1 and 6, between 1 and 7, between 1 and 8, between 1 and 9, or 
      between 1 and 10 basic amino acids 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 7
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Asn Lys Pro Phe 
1               5                   10                  15      


Leu Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25              


<210> 8
<211> 12
<212> PRT
<213> Homo sapiens

<400> 8
Arg Arg Arg Phe Asn Arg Pro Phe Leu Arg Arg Arg 
1               5                   10          


<210> 9
<211> 12
<212> PRT
<213> Homo sapiens

<400> 9
Arg Arg Arg Phe Asn Lys Pro Phe Leu Arg Arg Arg 
1               5                   10          


<210> 10
<211> 6
<212> PRT
<213> Homo sapiens

<400> 10
Phe Asn Arg Pro Phe Leu 
1               5       


<210> 11
<211> 6
<212> PRT
<213> Homo sapiens

<400> 11
Phe Asn Lys Pro Phe Leu 
1               5       


<210> 12
<211> 17
<212> PRT
<213> Homo sapiens

<400> 12
Ala Ala Ala Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210> 13
<211> 17
<212> PRT
<213> Homo sapiens

<400> 13
Val Lys Phe Ala Ala Ala Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210> 14
<211> 17
<212> PRT
<213> Homo sapiens

<400> 14
Val Lys Phe Asn Lys Pro Ala Ala Ala Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210> 15
<211> 17
<212> PRT
<213> Homo sapiens

<400> 15
Val Lys Phe Asn Lys Pro Phe Val Phe Ala Ala Ala Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210> 16
<211> 17
<212> PRT
<213> Homo sapiens

<400> 16
Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Ala Ala Ala Thr 
1               5                   10                  15      


Lys 
    


<210> 17
<211> 17
<212> PRT
<213> Homo sapiens

<400> 17
Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Ala Ala 
1               5                   10                  15      


Ala 
    


<210> 18
<211> 36
<212> PRT
<213> Homo sapiens

<400> 18
Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met 
1               5                   10                  15      


Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn 
            20                  25                  30          


Pro Thr Gln Lys 
        35      


<210> 19
<211> 39
<212> PRT
<213> Homo sapiens

<400> 19
Ser Ala Gln Thr Asn Arg His Ile Leu Arg Phe Asn Arg Pro Phe Leu 
1               5                   10                  15      


Val Val Ile Phe Ser Thr Ser Thr Gln Ser Val Leu Phe Leu Gly Lys 
            20                  25                  30          


Val Val Asp Pro Thr Lys Pro 
        35                  


<210> 20
<211> 40
<212> PRT
<213> Homo sapiens

<400> 20
Ser Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe 
1               5                   10                  15      


Leu Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser 
            20                  25                  30          


Lys Val Thr Asn Pro Lys Gln Ala 
        35                  40  


<210> 21
<211> 38
<212> PRT
<213> Rattus sp.

<400> 21
Ser Gly Arg Pro Pro Met Ile Val Trp Phe Asn Arg Pro Phe Leu Ile 
1               5                   10                  15      


Ala Val Ser His Thr His Gly Gln Thr Ile Leu Phe Met Ala Lys Val 
            20                  25                  30          


Ile Asn Pro Val Gly Ala 
        35              


<210> 22
<211> 38
<212> PRT
<213> Rattus sp.

<400> 22
Lys Ser Leu Pro Gln Thr Ile Pro Leu Leu Asn Phe Asn Arg Pro Phe 
1               5                   10                  15      


Met Leu Val Ile Thr Asp Asp Asn Gly Gln Ser Val Phe Phe Met Gly 
            20                  25                  30          


Lys Val Thr Asn Pro Met 
        35              


<210> 23
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Ser Ala Gln Val Glu Thr Ile Val Arg Phe Asn Arg Pro Phe Leu Val 
1               5                   10                  15      


Ile Ile Val Ser Thr Asn Thr Gln 
            20                  


<210> 24
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Ser Ile Pro Pro Gln Met Ile Val Trp Phe Asn Arg Pro Phe Leu Ile 
1               5                   10                  15      


Ala Ile Ser His Thr His Thr Gln 
            20                  


<210> 25
<211> 22
<212> PRT
<213> Homo sapiens

<400> 25
Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met 
1               5                   10                  15      


Ile Glu Gln Asn Thr Lys 
            20          


<210> 26
<211> 25
<212> PRT
<213> Homo sapiens

<400> 26
Ser Ala Gln Thr Asn Arg His Ile Leu Arg Phe Asn Arg Pro Phe Leu 
1               5                   10                  15      


Val Val Ile Phe Ser Thr Ser Thr Gln 
            20                  25  


<210> 27
<211> 26
<212> PRT
<213> Homo sapiens

<400> 27
Ser Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe 
1               5                   10                  15      


Leu Met Ile Ile Val Pro Thr Asp Thr Gln 
            20                  25      


<210> 28
<211> 26
<212> PRT
<213> Rattus sp.

<400> 28
Lys Ser Leu Pro Gln Thr Ile Pro Leu Leu Asn Phe Asn Arg Pro Phe 
1               5                   10                  15      


Met Leu Val Ile Thr Asp Asp Asn Gly Gln 
            20                  25      


<210> 29
<211> 21
<212> PRT
<213> Homo sapiens

<400> 29
Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile 
1               5                   10                  15      


Glu Gln Asn Thr Lys 
            20      


<210> 30
<211> 21
<212> PRT
<213> Homo sapiens

<400> 30
Asn Arg His Ile Leu Arg Phe Asn Arg Pro Phe Leu Val Val Ile Phe 
1               5                   10                  15      


Ser Thr Ser Thr Gln 
            20      


<210> 31
<211> 21
<212> PRT
<213> Homo sapiens

<400> 31
Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu Met Ile Ile Val 
1               5                   10                  15      


Pro Thr Asp Thr Gln 
            20      


<210> 32
<211> 21
<212> PRT
<213> Rattus sp.

<400> 32
Thr Ile Pro Leu Leu Asn Phe Asn Arg Pro Phe Met Leu Val Ile Thr 
1               5                   10                  15      


Asp Asp Asn Gly Gln 
            20      


<210> 33
<211> 11
<212> PRT
<213> Homo sapiens

<400> 33
Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met 
1               5                   10      


<210> 34
<211> 22
<212> PRT
<213> Homo sapiens

<400> 34
Ser Ile Pro Pro Glu Val Lys Ala Ala Ala Ala Ala Ala Phe Leu Met 
1               5                   10                  15      


Ile Glu Gln Asn Thr Lys 
            20          


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Val or Leu

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Val, Leu or Met

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Met, Ile or Val

<220>
<221> MOD_RES
<222> (12)..(16)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 35
Xaa Xaa Phe Asn Arg Pro Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Gln 
    


<210> 36
<211> 9
<212> PRT
<213> Homo sapiens

<400> 36
Phe Leu Met Ile Glu Gln Asn Thr Lys 
1               5                   


<210> 37
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 37
His His His His His His 
1               5       


<210> 38
<211> 23
<212> PRT
<213> Homo sapiens

<400> 38
Arg Arg Arg Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
1               5                   10                  15      


Gln Asn Thr Lys Arg Arg Arg 
            20              


<210> 39
<211> 17
<212> PRT
<213> Homo sapiens

<400> 39
Arg Arg Arg Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Arg Arg 
1               5                   10                  15      


Arg 
    


<210> 40
<211> 17
<212> PRT
<213> Homo sapiens

<400> 40
Leu Arg Phe Asn Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gln 
    


<210> 41
<211> 11
<212> PRT
<213> Homo sapiens

<400> 41
Leu Arg Phe Asn Arg Pro Phe Leu Val Val Ile 
1               5                   10      


<210> 42
<211> 23
<212> PRT
<213> Homo sapiens

<400> 42
Arg Arg Arg Leu Arg Phe Asn Arg Pro Phe Leu Val Val Ile Phe Ser 
1               5                   10                  15      


Thr Ser Thr Gln Arg Arg Arg 
            20              


<210> 43
<211> 17
<212> PRT
<213> Homo sapiens

<400> 43
Arg Arg Arg Leu Arg Phe Asn Arg Pro Phe Leu Val Val Ile Arg Arg 
1               5                   10                  15      


Arg 
    


<210> 44
<211> 17
<212> PRT
<213> Homo sapiens

<400> 44
Val Arg Phe Asn Arg Pro Phe Leu Met Ile Ile Val Pro Thr Asp Thr 
1               5                   10                  15      


Gln 
    


<210> 45
<211> 11
<212> PRT
<213> Homo sapiens

<400> 45
Val Arg Phe Asn Arg Pro Phe Leu Met Ile Ile 
1               5                   10      


<210> 46
<211> 23
<212> PRT
<213> Homo sapiens

<400> 46
Arg Arg Arg Val Arg Phe Asn Arg Pro Phe Leu Met Ile Ile Val Pro 
1               5                   10                  15      


Thr Asp Thr Gln Arg Arg Arg 
            20              


<210> 47
<211> 17
<212> PRT
<213> Homo sapiens

<400> 47
Arg Arg Arg Val Arg Phe Asn Arg Pro Phe Leu Met Ile Ile Arg Arg 
1               5                   10                  15      


Arg 
    


<210> 48
<211> 8
<212> PRT
<213> Homo sapiens

<400> 48
Val Arg Phe Asn Arg Pro Phe Leu 
1               5               


<210> 49
<211> 14
<212> PRT
<213> Homo sapiens

<400> 49
Arg Arg Arg Val Arg Phe Asn Arg Pro Phe Leu Arg Arg Arg 
1               5                   10                  


<210> 50
<211> 21
<212> PRT
<213> Homo sapiens

<400> 50
Ile Pro Pro Glu Val Lys Ala Ala Ala Ala Ala Ala Phe Leu Met Ile 
1               5                   10                  15      


Glu Gln Asn Thr Lys 
            20      


<210> 51
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Phe Pro Lys Met Val Pro Gln Phe Asn Thr Glu Leu Lys Ile Phe Pro 
1               5                   10                  15      


Glu Val Asn Ile Lys 
            20      


<210> 52
<211> 17
<212> PRT
<213> Homo sapiens

<400> 52
Ala Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210> 53
<211> 17
<212> PRT
<213> Homo sapiens

<400> 53
Val Ala Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210> 54
<211> 17
<212> PRT
<213> Homo sapiens

<400> 54
Val Lys Ala Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210> 55
<211> 17
<212> PRT
<213> Homo sapiens

<400> 55
Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Ala 
1               5                   10                  15      


Lys 
    


<210> 56
<211> 17
<212> PRT
<213> Homo sapiens

<400> 56
Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Ala 
    


<210> 57
<211> 8
<212> PRT
<213> Homo sapiens

<400> 57
Lys Phe Asn Lys Pro Phe Leu Met 
1               5               


