                         SEQUENCE LISTING

<110>  University of Rochester
       Fasan, Rudi
       Jordan, Craig T.
       Kolev, Joshua N.
 
<120>  PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR
        USE AS ANTICANCER AGENTS

<130>  1625_006PCT

<150>  US 61/831,756
<151>  2013-06-06

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  1049
<212>  PRT
<213>  Bacillus megaterium

<400>  1

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  2
<211>  1065
<212>  PRT
<213>  Bacillus cereus

<400>  2

Met Asp Lys Lys Val Ser Ala Ile Pro Gln Pro Lys Thr Tyr Gly Pro 
1               5                   10                  15      


Leu Gly Asn Leu Pro Leu Ile Asp Lys Asp Lys Pro Thr Leu Ser Phe 
            20                  25                  30          


Ile Lys Ile Ala Glu Glu Tyr Gly Pro Ile Phe Gln Ile Gln Thr Leu 
        35                  40                  45              


Ser Asp Thr Ile Ile Val Ile Ser Gly His Glu Leu Val Ala Glu Val 
    50                  55                  60                  


Cys Asp Glu Thr Arg Phe Asp Lys Ser Ile Glu Gly Ala Leu Ala Lys 
65                  70                  75                  80  


Val Arg Ala Phe Ala Gly Asp Gly Leu Phe Thr Ser Glu Thr Gln Glu 
                85                  90                  95      


Pro Asn Trp Lys Lys Ala His Asn Ile Leu Met Pro Thr Phe Ser Gln 
            100                 105                 110         


Arg Ala Met Lys Asp Tyr His Ala Met Met Val Asp Ile Ala Val Gln 
        115                 120                 125             


Leu Val Gln Lys Trp Ala Arg Leu Asn Pro Asn Glu Asn Val Asp Val 
    130                 135                 140                 


Pro Glu Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly 
145                 150                 155                 160 


Phe Asn Tyr Arg Phe Asn Ser Phe Tyr Arg Glu Thr Pro His Pro Phe 
                165                 170                 175     


Ile Thr Ser Met Thr Arg Ala Leu Asp Glu Ala Met His Gln Leu Gln 
            180                 185                 190         


Arg Leu Asp Ile Glu Asp Lys Leu Met Trp Arg Thr Lys Arg Gln Phe 
        195                 200                 205             


Gln His Asp Ile Gln Ser Met Phe Ser Leu Val Asp Asn Ile Ile Ala 
    210                 215                 220                 


Glu Arg Lys Ser Ser Gly Asn Gln Glu Glu Asn Asp Leu Leu Ser Arg 
225                 230                 235                 240 


Met Leu His Val Gln Asp Pro Glu Thr Gly Glu Lys Leu Asp Asp Glu 
                245                 250                 255     


Asn Ile Arg Phe Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr 
            260                 265                 270         


Thr Ser Gly Leu Leu Ser Phe Ala Ile Tyr Phe Leu Leu Lys Asn Pro 
        275                 280                 285             


Asp Lys Leu Lys Lys Ala Tyr Glu Glu Val Asp Arg Val Leu Thr Asp 
    290                 295                 300                 


Pro Thr Pro Thr Tyr Gln Gln Val Met Lys Leu Lys Tyr Ile Arg Met 
305                 310                 315                 320 


Ile Leu Asn Glu Ser Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser 
                325                 330                 335     


Leu Tyr Ala Lys Glu Asp Thr Val Ile Gly Gly Lys Tyr Pro Ile Lys 
            340                 345                 350         


Lys Gly Glu Asp Arg Ile Ser Val Leu Ile Pro Gln Leu His Arg Asp 
        355                 360                 365             


Lys Asp Ala Trp Gly Asp Asn Val Glu Glu Phe Gln Pro Glu Arg Phe 
    370                 375                 380                 


Glu Asp Leu Asp Lys Val Pro His His Ala Tyr Lys Pro Phe Gly Asn 
385                 390                 395                 400 


Gly Gln Arg Ala Cys Ile Gly Met Gln Phe Ala Leu His Glu Ala Thr 
                405                 410                 415     


Leu Val Met Gly Met Leu Leu Gln His Phe Glu Phe Ile Asp Tyr Glu 
            420                 425                 430         


Asp Tyr Gln Leu Asp Val Lys Gln Thr Leu Thr Leu Lys Pro Gly Asp 
        435                 440                 445             


Phe Lys Ile Arg Ile Val Pro Arg Asn Gln Asn Ile Ser His Thr Thr 
    450                 455                 460                 


Val Leu Ala Pro Thr Glu Glu Lys Leu Lys Asn His Glu Ile Lys Gln 
465                 470                 475                 480 


Gln Val Gln Lys Thr Pro Ser Ile Ile Gly Ala Asp Asn Leu Ser Leu 
                485                 490                 495     


Leu Val Leu Tyr Gly Ser Asp Thr Gly Val Ala Glu Gly Ile Ala Arg 
            500                 505                 510         


Glu Leu Ala Asp Thr Ala Ser Leu Glu Gly Val Gln Thr Glu Val Ala 
        515                 520                 525             


Ala Leu Asn Asp Arg Ile Gly Ser Leu Pro Lys Glu Gly Ala Val Leu 
    530                 535                 540                 


Ile Val Thr Ser Ser Tyr Asn Gly Lys Pro Pro Ser Asn Ala Gly Gln 
545                 550                 555                 560 


Phe Val Gln Trp Leu Glu Glu Leu Lys Pro Asp Glu Leu Lys Gly Val 
                565                 570                 575     


Gln Tyr Ala Val Phe Gly Cys Gly Asp His Asn Trp Ala Ser Thr Tyr 
            580                 585                 590         


Gln Arg Ile Pro Arg Tyr Ile Asp Glu Gln Met Ala Gln Lys Gly Ala 
        595                 600                 605             


Thr Arg Phe Ser Thr Arg Gly Glu Ala Asp Ala Ser Gly Asp Phe Glu 
    610                 615                 620                 


Glu Gln Leu Glu Gln Trp Lys Glu Ser Met Trp Ser Asp Ala Met Lys 
625                 630                 635                 640 


Ala Phe Gly Leu Glu Leu Asn Lys Asn Met Glu Lys Glu Arg Ser Thr 
                645                 650                 655     


Leu Ser Leu Gln Phe Val Ser Arg Leu Gly Gly Ser Pro Leu Ala Arg 
            660                 665                 670         


Thr Tyr Glu Ala Val Tyr Ala Ser Ile Leu Glu Asn Arg Glu Leu Gln 
        675                 680                 685             


Ser Ser Ser Ser Glu Arg Ser Thr Arg His Ile Glu Ile Ser Leu Pro 
    690                 695                 700                 


Glu Gly Ala Thr Tyr Lys Glu Gly Asp His Leu Gly Val Leu Pro Ile 
705                 710                 715                 720 


Asn Ser Glu Lys Asn Val Asn Arg Ile Leu Lys Arg Phe Gly Leu Asn 
                725                 730                 735     


Gly Lys Asp Gln Val Ile Leu Ser Ala Ser Gly Arg Ser Val Asn His 
            740                 745                 750         


Ile Pro Leu Asp Ser Pro Val Arg Leu Tyr Asp Leu Leu Ser Tyr Ser 
        755                 760                 765             


Val Glu Val Gln Glu Ala Ala Thr Arg Ala Gln Ile Arg Glu Met Val 
    770                 775                 780                 


Thr Phe Thr Ala Cys Pro Pro His Lys Lys Glu Leu Glu Ser Leu Leu 
785                 790                 795                 800 


Glu Asp Gly Val Tyr His Glu Gln Ile Leu Lys Lys Arg Ile Ser Met 
                805                 810                 815     


Leu Asp Leu Leu Glu Lys Tyr Glu Ala Cys Glu Ile Arg Phe Glu Arg 
            820                 825                 830         


Phe Leu Glu Leu Leu Pro Ala Leu Lys Pro Arg Tyr Tyr Ser Ile Ser 
        835                 840                 845             


Ser Ser Pro Leu Ile Ala Gln Asp Arg Leu Ser Ile Thr Val Gly Val 
    850                 855                 860                 


Val Asn Ala Pro Ala Trp Ser Gly Glu Gly Thr Tyr Glu Gly Val Ala 
865                 870                 875                 880 


Ser Asn Tyr Leu Ala Gln Arg His Asn Lys Asp Glu Ile Ile Cys Phe 
                885                 890                 895     


Ile Arg Thr Pro Gln Ser Asn Phe Gln Leu Pro Glu Asn Pro Glu Thr 
            900                 905                 910         


Pro Ile Ile Met Val Gly Pro Gly Thr Gly Ile Ala Pro Phe Arg Gly 
        915                 920                 925             


Phe Leu Gln Ala Arg Arg Val Gln Lys Gln Lys Gly Met Asn Leu Gly 
    930                 935                 940                 


Glu Ala His Leu Tyr Phe Gly Cys Arg His Pro Glu Lys Asp Tyr Leu 
945                 950                 955                 960 


Tyr Arg Thr Glu Leu Glu Asn Asp Glu Arg Asp Gly Leu Ile Ser Leu 
                965                 970                 975     


His Thr Ala Phe Ser Arg Leu Glu Gly His Pro Lys Thr Tyr Val Gln 
            980                 985                 990         


His Val Ile Lys Glu Asp Arg Met  Asn Leu Ile Ser Leu  Leu Asp Asn 
        995                 1000                 1005             


Gly Ala  His Leu Tyr Ile Cys  Gly Asp Gly Ser Lys  Met Ala Pro 
    1010                 1015                 1020             


Asp Val  Glu Asp Thr Leu Cys  Gln Ala Tyr Gln Glu  Ile His Glu 
    1025                 1030                 1035             


Val Ser  Glu Gln Glu Ala Arg  Asn Trp Leu Asp Arg  Leu Gln Asp 
    1040                 1045                 1050             


Glu Gly  Arg Tyr Gly Lys Asp  Val Trp Ala Gly Ile  
    1055                 1060                 1065 


<210>  3
<211>  1120
<212>  PRT
<213>  Aspergillus fumigatus

<400>  3

Met Ser Glu Ser Lys Thr Val Pro Ile Pro Gly Pro Arg Gly Val Pro 
1               5                   10                  15      


Leu Leu Gly Asn Ile Tyr Asp Ile Glu Gln Glu Val Pro Leu Arg Ser 
            20                  25                  30          


Ile Asn Leu Met Ala Asp Gln Tyr Gly Pro Ile Tyr Arg Leu Thr Thr 
        35                  40                  45              


Phe Gly Trp Ser Arg Val Phe Val Ser Thr His Glu Leu Val Asp Glu 
    50                  55                  60                  


Val Cys Asp Glu Glu Arg Phe Thr Lys Val Val Thr Ala Gly Leu Asn 
65                  70                  75                  80  


Gln Ile Arg Asn Gly Val His Asp Gly Leu Phe Thr Ala Asn Phe Pro 
                85                  90                  95      


Gly Glu Glu Asn Trp Ala Ile Ala His Arg Val Leu Val Pro Ala Phe 
            100                 105                 110         


Gly Pro Leu Ser Ile Arg Gly Met Phe Asp Glu Met Tyr Asp Ile Ala 
        115                 120                 125             


Thr Gln Leu Val Met Lys Trp Ala Arg His Gly Pro Thr Val Pro Ile 
    130                 135                 140                 


Met Val Thr Asp Asp Phe Thr Arg Leu Thr Leu Asp Thr Ile Ala Leu 
145                 150                 155                 160 


Cys Ala Met Gly Thr Arg Phe Asn Ser Phe Tyr His Glu Glu Met His 
                165                 170                 175     


Pro Phe Val Glu Ala Met Val Gly Leu Leu Gln Gly Ser Gly Asp Arg 
            180                 185                 190         


Ala Arg Arg Pro Ala Leu Leu Asn Asn Leu Pro Thr Ser Glu Asn Ser 
        195                 200                 205             


Lys Tyr Trp Asp Asp Ile Ala Phe Leu Arg Asn Leu Ala Gln Glu Leu 
    210                 215                 220                 


Val Glu Ala Arg Arg Lys Asn Pro Glu Asp Lys Lys Asp Leu Leu Asn 
225                 230                 235                 240 


Ala Leu Ile Leu Gly Arg Asp Pro Lys Thr Gly Lys Gly Leu Thr Asp 
                245                 250                 255     


Glu Ser Ile Ile Asp Asn Met Ile Thr Phe Leu Ile Ala Gly His Glu 
            260                 265                 270         


Thr Thr Ser Gly Leu Leu Ser Phe Leu Phe Tyr Tyr Leu Leu Lys Thr 
        275                 280                 285             


Pro Asn Ala Tyr Lys Lys Ala Gln Glu Glu Val Asp Ser Val Val Gly 
    290                 295                 300                 


Arg Arg Lys Ile Thr Val Glu Asp Met Ser Arg Leu Pro Tyr Leu Asn 
305                 310                 315                 320 


Ala Val Met Arg Glu Thr Leu Arg Leu Arg Ser Thr Ala Pro Leu Ile 
                325                 330                 335     


Ala Val His Ala His Pro Glu Lys Asn Lys Glu Asp Pro Val Thr Leu 
            340                 345                 350         


Gly Gly Gly Lys Tyr Val Leu Asn Lys Asp Glu Pro Ile Val Ile Ile 
        355                 360                 365             


Leu Asp Lys Leu His Arg Asp Pro Gln Val Tyr Gly Pro Asp Ala Glu 
    370                 375                 380                 


Glu Phe Lys Pro Glu Arg Met Leu Asp Glu Asn Phe Glu Lys Leu Pro 
385                 390                 395                 400 


Lys Asn Ala Trp Lys Pro Phe Gly Asn Gly Met Arg Ala Cys Ile Gly 
                405                 410                 415     


Arg Pro Phe Ala Trp Gln Glu Ala Leu Leu Val Val Ala Ile Leu Leu 
            420                 425                 430         


Gln Asn Phe Asn Phe Gln Met Asp Asp Pro Ser Tyr Asn Leu His Ile 
        435                 440                 445             


Lys Gln Thr Leu Thr Ile Lys Pro Lys Asp Phe His Met Arg Ala Thr 
    450                 455                 460                 


Leu Arg His Gly Leu Asp Ala Thr Lys Leu Gly Ile Ala Leu Ser Gly 
465                 470                 475                 480 


Ser Ala Asp Arg Ala Pro Pro Glu Ser Ser Gly Ala Ala Ser Arg Val 
                485                 490                 495     


Arg Lys Gln Ala Thr Pro Pro Ala Gly Gln Leu Lys Pro Met His Ile 
            500                 505                 510         


Phe Phe Gly Ser Asn Thr Gly Thr Cys Glu Thr Phe Ala Arg Arg Leu 
        515                 520                 525             


Ala Asp Asp Ala Val Gly Tyr Gly Phe Ala Ala Asp Val Gln Ser Leu 
    530                 535                 540                 


Asp Ser Ala Met Gln Asn Val Pro Lys Asp Glu Pro Val Val Phe Ile 
545                 550                 555                 560 


Thr Ala Ser Tyr Glu Gly Gln Pro Pro Asp Asn Ala Ala His Phe Phe 
                565                 570                 575     


Glu Trp Leu Ser Ala Leu Lys Glu Asn Glu Leu Glu Gly Val Asn Tyr 
            580                 585                 590         


Ala Val Phe Gly Cys Gly His His Asp Trp Gln Ala Thr Phe His Arg 
        595                 600                 605             


Ile Pro Lys Ala Val Asn Gln Leu Val Ala Glu His Gly Gly Asn Arg 
    610                 615                 620                 


Leu Cys Asp Leu Gly Leu Ala Asp Ala Ala Asn Ser Asp Met Phe Thr 
625                 630                 635                 640 


Asp Phe Asp Ser Trp Gly Glu Ser Thr Phe Trp Pro Ala Ile Thr Ser 
                645                 650                 655     


Lys Phe Gly Gly Gly Lys Ser Asp Glu Pro Lys Pro Ser Ser Ser Leu 
            660                 665                 670         


Gln Val Glu Val Ser Thr Gly Met Arg Ala Ser Thr Leu Gly Leu Gln 
        675                 680                 685             


Leu Gln Glu Gly Leu Val Ile Asp Asn Gln Leu Leu Ser Ala Pro Asp 
    690                 695                 700                 


Val Pro Ala Lys Arg Met Ile Arg Phe Lys Leu Pro Ser Asp Met Ser 
705                 710                 715                 720 


Tyr Arg Cys Gly Asp Tyr Leu Ala Val Leu Pro Val Asn Pro Thr Ser 
                725                 730                 735     


Val Val Arg Arg Ala Ile Arg Arg Phe Asp Leu Pro Trp Asp Ala Met 
            740                 745                 750         


Leu Thr Ile Arg Lys Pro Ser Gln Ala Pro Lys Gly Ser Thr Ser Ile 
        755                 760                 765             


Pro Leu Asp Thr Pro Ile Ser Ala Phe Glu Leu Leu Ser Thr Tyr Val 
    770                 775                 780                 


Glu Leu Ser Gln Pro Ala Ser Lys Arg Asp Leu Thr Ala Leu Ala Asp 
785                 790                 795                 800 


Ala Ala Ile Thr Asp Ala Asp Ala Gln Ala Glu Leu Arg Tyr Leu Ala 
                805                 810                 815     


Ser Ser Pro Thr Arg Phe Thr Glu Glu Ile Val Lys Lys Arg Met Ser 
            820                 825                 830         


Pro Leu Asp Leu Leu Ile Arg Tyr Pro Ser Ile Lys Leu Pro Val Gly 
        835                 840                 845             


Asp Phe Leu Ala Met Leu Pro Pro Met Arg Val Arg Gln Tyr Ser Ile 
    850                 855                 860                 


Ser Ser Ser Pro Leu Ala Asp Pro Ser Glu Cys Ser Ile Thr Phe Ser 
865                 870                 875                 880 


Val Leu Asn Ala Pro Ala Leu Ala Ala Ala Ser Leu Pro Pro Ala Glu 
                885                 890                 895     


Arg Ala Glu Ala Glu Gln Tyr Met Gly Val Ala Ser Thr Tyr Leu Ser 
            900                 905                 910         


Glu Leu Lys Pro Gly Glu Arg Ala His Ile Ala Val Arg Pro Ser His 
        915                 920                 925             


Ser Gly Phe Lys Pro Pro Met Asp Leu Lys Ala Pro Met Ile Met Ala 
    930                 935                 940                 


Cys Ala Gly Ser Gly Leu Ala Pro Phe Arg Gly Phe Ile Met Asp Arg 
945                 950                 955                 960 


Ala Glu Lys Ile Arg Gly Arg Arg Ser Ser Val Gly Ala Asp Gly Gln 
                965                 970                 975     


Leu Pro Glu Val Glu Gln Pro Ala Lys Ala Ile Leu Tyr Val Gly Cys 
            980                 985                 990         


Arg Thr Lys Gly Lys Asp Asp Ile  His Ala Thr Glu Leu  Ala Glu Trp 
        995                 1000                 1005             


Ala Gln  Leu Gly Ala Val Asp  Val Arg Trp Ala Tyr  Ser Arg Pro 
    1010                 1015                 1020             


Glu Asp  Gly Ser Lys Gly Arg  His Val Gln Asp Leu  Met Leu Glu 
    1025                 1030                 1035             


Asp Arg  Glu Glu Leu Val Ser  Leu Phe Asp Gln Gly  Ala Arg Ile 
    1040                 1045                 1050             


Tyr Val  Cys Gly Ser Thr Gly  Val Gly Asn Gly Val  Arg Gln Ala 
    1055                 1060                 1065             


Cys Lys  Asp Ile Tyr Leu Glu  Arg Arg Arg Gln Leu  Arg Gln Ala 
    1070                 1075                 1080             


Ala Arg  Glu Arg Gly Glu Glu  Val Pro Ala Glu Glu  Asp Glu Asp 
    1085                 1090                 1095             


Ala Ala  Ala Glu Gln Phe Leu  Asp Asn Leu Arg Thr  Lys Glu Arg 
    1100                 1105                 1110             


Tyr Ala  Thr Asp Val Phe Thr  
    1115                 1120 


<210>  4
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  4

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  5
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  5

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Ala Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu Tyr Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Ile Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Thr Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  6
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  6

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Ala Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  7
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  7

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Ala Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Ile Thr Ser Trp Thr His Glu Ile Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  8
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  8

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Ala Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Ile Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  9
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  9

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Ala Val Arg 
65                  70                  75                  80  


Asp Phe Leu Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  10
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  10

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys 
        35                  40                  45              


Val Thr Arg Tyr Ile Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Pro Leu Lys Phe Phe Arg 
65                  70                  75                  80  


Asp Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ser Met Asn Lys Pro Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Val Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Gly Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  11
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  11

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Ala Arg 
65                  70                  75                  80  


Asp Trp Ser Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  12
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  12

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Ala Arg 
65                  70                  75                  80  


Asp Ser Val Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Thr Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  13
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  13

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Thr Arg 
65                  70                  75                  80  


Asp Ile Ala Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Thr Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  14
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  14

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Asn Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Thr Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  15
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  15

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Asn Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Ala Asp Glu Ser Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  16
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  16

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Thr Arg 
65                  70                  75                  80  


Asp Ile Ala Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  17
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  17

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Thr Arg 
65                  70                  75                  80  


Asp Ile Thr Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Thr Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  18
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  18

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Asn Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Val Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Ala Asp Glu Ser Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  19
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  19

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Thr Arg 
65                  70                  75                  80  


Asp Ile Thr Gly Asp Gly Leu Ala Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  20
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  20

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Thr Arg 
65                  70                  75                  80  


Asp Ile Thr Gly Asp Gly Leu Ser Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Val Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Val Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


