                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

<130> 030258-076041-PCT

<140>
<141>

<150> 61/831,758
<151> 2013-06-06

<160> 63    

<170> PatentIn version 3.5

<210> 1
<211> 4526
<212> DNA
<213> Homo sapiens

<400> 1
acggctgcgc agatgccgac tttagaggag gcggagtttc ggccttcgcc tgctggaaaa       60

gcagtaggat cggccagtgg cgacagcagg agctgagcct aagccctggc ggggctttgg      120

gctgtagatt cctgtctgac taaagggacc tcaaaaagga gggaaaatgg cttctgagtc      180

tgaaactctg aatcccagtg ctaggataat gaccttttat ccaactatgg aagagttccg      240

aaacttcagt agatacattg cctacattga atcccaagga gctcatcggg cagggctagc      300

caaggttgtt cctccaaaag agtggaagcc acgagcatcc tatgatgaca ttgatgattt      360

ggtcattcct gcccccattc aacagctggt gacggggcag tctggcctct ttactcagta      420

caacatacag aagaaagcca tgactgttcg agagttccgc aagatagcca atagcgataa      480

gtactgtacc ccacgctata gtgagtttga agagctcgag cggaaatact ggaaaaatct      540

tacattcaat cctccaatct atggtgcaga tgtgaatggt accctctatg aaaagcatgt      600

tgatgagtgg aatattggcc ggctgagaac aatcctggac ttggtggaaa aggagagtgg      660

gatcaccatt gagggtgtga acaccccata cctgtacttt ggcatgtgga agacatcctt      720

tgcttggcac actgaagaca tggacctcta cagcatcaac tacctgcact ttggagaacc      780

aaagtcctgg tactctgttc cacctgagca tggaaagcgg ttggaacgcc tcgccaaagg      840

ctttttccca ggaagtgctc aaagctgtga ggcatttctc cgccacaaga tgaccctgat      900

ttccccgtta atgctgaaga aatatggaat tccctttgac aaggtgactc aagaggctgg      960

agagtttatg atcactttcc cttatggtta ccatgccggc tttaaccatg gttttaactg     1020

tgcggagtct accaattttg ctacccgtcg gtggattgag tacggcaagc aagctgtgct     1080

gtgctcctgt agaaaggaca tggtgaagat ctccatggat gtgtttgtga gaaagttcca     1140

gccagaaagg tacaaacttt ggaaagctgg gaaggacaac acagttattg accatactct     1200

gcccacgcca gaagcagctg agtttcttaa ggagagtgaa ctgcctccaa gagctggcaa     1260

cgaggaggag tgcccagagg aggacatgga aggggtggag gatggagagg aaggagacct     1320

gaagacaagc ctggccaagc accgaatagg gacaaagagg caccgagttt gtcttgaaat     1380

accacaggag gtgagtcaga gtgagctctt ccccaaggag gatctgagtt ctgagcagta     1440

tgagatgacg gagtgcccgg cagccctcgc ccctgtgagg cccacccata gctctgtgcg     1500

gcaagttgag gatggtctta ccttcccaga ttattctgac tccactgaag tcaaatttga     1560

agagcttaaa aatgtcaaac tagaagagga ggatgaggag gaagaacaag cagcagctgc     1620

cttggatctt tctgtgaatc ctgcgtctgt agggggacgc cttgtcttct caggctccaa     1680

aaagaaatca tcttctagcc tgggctctgg ctcttcacgg gattctatct cttctgattc     1740

agaaactagt gagcctctct cctgccgagc ccaagggcaa acgggagttc tcactgtgca     1800

cagttatgcc aaaggggatg gcagggtcac tgtgggagag ccatgcacga ggaagaaagg     1860

aagcgccgct agaagtttca gtgagcggga gctggcagag gttgcagatg aatacatgtt     1920

ttccctagaa gagaataaga agtccaaggg acgccgtcag cctttaagca agctcccccg     1980

ccatcaccca cttgtgctgc aggagtgtgt cagtgatgat gagacatctg aacagctgac     2040

ccctgaggaa gaggctgagg agacagaggc ctgggccaag cctctgagcc aactgtggca     2100

gaaccgacct ccaaactttg aggctgagaa ggaattcaat gagaccatgg cccaacaggc     2160

ccctcactgc gctgtctgta tgatcttcca gacttatcat caggttgaat ttggaggctt     2220

taatcagaac tgtggaaatg cttcagattt agccccccag aagcagagga ccaagccatt     2280

gattccagaa atgtgcttca cttcgactgg ctgcagcacg gacatcaacc tttctactcc     2340

ttatcttgag gaggatggca ccagcatact cgtttcctgc aagaagtgca gcgtccgggt     2400

ccatgccagt tgctatgggg tcccccctgc aaaggcttct gaagactgga tgtgttctcg     2460

gtgttcagcc aatgccctag aggaggactg ctgtttatgc tcattacgag gaggggccct     2520

gcagagagca aatgatgaca ggtgggtcca cgtttcatgt gctgtggcaa ttctggaagc     2580

aaggtttgtc aacattgcag aaagaagtcc ggtggatgtg agcaaaatcc ccctgccccg     2640

cttcaaactg aaatgtatct tctgtaagaa gcggaggaaa agaactgctg gctgctgtgt     2700

gcagtgttct cacggccgct gcccaactgc cttccatgtg agctgcgccc aggctgccgg     2760

tgtgatgatg cagcctgacg actggccttt tgtggtcttc attacctgct ttcggcacaa     2820

gattcctaat ttggagcgtg ccaagggggc cttgcaaagc atcactgcag gccagaaagt     2880

cattagcaag cataagaacg ggcgcttcta ccagtgtgaa gtggtcaggc tcaccaccga     2940

gaccttctat gaagtcaact ttgatgatgg ctccttcagc gacaatcttt atcctgagga     3000

catagtgagc caggactgtc tccagtttgg tcctcctgct gaaggggaag tggtccaagt     3060

gagatggaca gacggccaag tctatggagc caagtttgtg gcctcccacc ctatccaaat     3120

gtaccaggtg gagtttgagg atggctcaca acttgtggtt aagagagatg atgtatacac     3180

actggatgaa gagcttccca agagagtcaa atctagactg tcagtagcct cagacatgcg     3240

cttcaatgag attttcacag agaaagaggt taagcaagaa aagaaacggc aacgagttat     3300

caactcaaga taccgggaag attatattga gcctgcacta taccgggcca tcatggagta     3360

ggtgcttcca gggtccaagg gattctcagc catccaggca agagcactct gggttccaca     3420

gcacagcaga catggaacgc tgaagtctct gaaagtgaag ttgtaaaaag aaaaggaatg     3480

aaataaccga cccatcatct tctcacccac cctcattgca ttccgctgta gtgaaaggac     3540

gagccatttc tgggcacgtg gcagcagtcg ctgatctccc agctgagggg ctgagcactg     3600

gaatgctgtg gctgcactgg ccccagtcca tagaggggtc aactatgctg gctggactgg     3660

ctgccttgtt cctggcctag gacttagctt cataactatc acctgcaccg actaggctga     3720

ggtgctggta cttgccccaa cccctacttt tgtatttata tgtgtgtgtg tgtgtgcgtg     3780

cgtgcgtgcg tgcgtgtatg tttggtctgg accagcttct gccagcccct ggcctttact     3840

ttcttccttg cctatgcagg gcaaacaaaa tgtgaaattc tgccctcagc tgagctgagt     3900

aagggctcct gggggttggc tggagatggg tgtggcatct gtccaggcct ggaaccgtct     3960

caagacagtg ctggcaaagc tgcagtattg agatgctaag gagctgatgc cacctctttg     4020

tcttccccta aaggagaaca tggggataac atgggtgtgt gcccacaaca ctctaggtgc     4080

agagcccctg tggcaaagta ttacagggtg tgggtgggga ttaccctgaa tcggggattt     4140

taatgatgga agcaggcaga gcctggtggg tgattctgtc aacagaaaat tgcaatcatg     4200

caggggctgg gagggttagg atgaaaaaac tggggccatt ggaggcccac tgtaggtggg     4260

agggagctga ttttggggtg gggggtggga ctagagggca atactgaagg ggttaaacag     4320

gtttttgctc ctcaagaatt tgtttgcctg ggcccaggat tggagggctt cacaccaata     4380

ccctgtgtat acaagaatca gatttataat acttcccctt ttttgttacg tatgaacact     4440

ataaaccaaa ttattttgaa aactggtgca tcaccttgtc cttagcaata aaatgtgttg     4500

agcagaggaa aaaaaaaaaa aaaaaa                                          4526


<210> 2
<211> 1064
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ser Glu Ser Glu Thr Leu Asn Pro Ser Ala Arg Ile Met Thr 
1               5                   10                  15      


Phe Tyr Pro Thr Met Glu Glu Phe Arg Asn Phe Ser Arg Tyr Ile Ala 
            20                  25                  30          


Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Val Val 
        35                  40                  45              


Pro Pro Lys Glu Trp Lys Pro Arg Ala Ser Tyr Asp Asp Ile Asp Asp 
    50                  55                  60                  


Leu Val Ile Pro Ala Pro Ile Gln Gln Leu Val Thr Gly Gln Ser Gly 
65                  70                  75                  80  


Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Arg Glu 
                85                  90                  95      


Phe Arg Lys Ile Ala Asn Ser Asp Lys Tyr Cys Thr Pro Arg Tyr Ser 
            100                 105                 110         


Glu Phe Glu Glu Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe Asn 
        115                 120                 125             


Pro Pro Ile Tyr Gly Ala Asp Val Asn Gly Thr Leu Tyr Glu Lys His 
    130                 135                 140                 


Val Asp Glu Trp Asn Ile Gly Arg Leu Arg Thr Ile Leu Asp Leu Val 
145                 150                 155                 160 


Glu Lys Glu Ser Gly Ile Thr Ile Glu Gly Val Asn Thr Pro Tyr Leu 
                165                 170                 175     


Tyr Phe Gly Met Trp Lys Thr Ser Phe Ala Trp His Thr Glu Asp Met 
            180                 185                 190         


Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser Trp 
        195                 200                 205             


Tyr Ser Val Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala Lys 
    210                 215                 220                 


Gly Phe Phe Pro Gly Ser Ala Gln Ser Cys Glu Ala Phe Leu Arg His 
225                 230                 235                 240 


Lys Met Thr Leu Ile Ser Pro Leu Met Leu Lys Lys Tyr Gly Ile Pro 
                245                 250                 255     


Phe Asp Lys Val Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe Pro 
            260                 265                 270         


Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser 
        275                 280                 285             


Thr Asn Phe Ala Thr Arg Arg Trp Ile Glu Tyr Gly Lys Gln Ala Val 
    290                 295                 300                 


Leu Cys Ser Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe 
305                 310                 315                 320 


Val Arg Lys Phe Gln Pro Glu Arg Tyr Lys Leu Trp Lys Ala Gly Lys 
                325                 330                 335     


Asp Asn Thr Val Ile Asp His Thr Leu Pro Thr Pro Glu Ala Ala Glu 
            340                 345                 350         


Phe Leu Lys Glu Ser Glu Leu Pro Pro Arg Ala Gly Asn Glu Glu Glu 
        355                 360                 365             


Cys Pro Glu Glu Asp Met Glu Gly Val Glu Asp Gly Glu Glu Gly Asp 
    370                 375                 380                 


Leu Lys Thr Ser Leu Ala Lys His Arg Ile Gly Thr Lys Arg His Arg 
385                 390                 395                 400 


Val Cys Leu Glu Ile Pro Gln Glu Val Ser Gln Ser Glu Leu Phe Pro 
                405                 410                 415     


Lys Glu Asp Leu Ser Ser Glu Gln Tyr Glu Met Thr Glu Cys Pro Ala 
            420                 425                 430         


Ala Leu Ala Pro Val Arg Pro Thr His Ser Ser Val Arg Gln Val Glu 
        435                 440                 445             


Asp Gly Leu Thr Phe Pro Asp Tyr Ser Asp Ser Thr Glu Val Lys Phe 
    450                 455                 460                 


Glu Glu Leu Lys Asn Val Lys Leu Glu Glu Glu Asp Glu Glu Glu Glu 
465                 470                 475                 480 


Gln Ala Ala Ala Ala Leu Asp Leu Ser Val Asn Pro Ala Ser Val Gly 
                485                 490                 495     


Gly Arg Leu Val Phe Ser Gly Ser Lys Lys Lys Ser Ser Ser Ser Leu 
            500                 505                 510         


Gly Ser Gly Ser Ser Arg Asp Ser Ile Ser Ser Asp Ser Glu Thr Ser 
        515                 520                 525             


Glu Pro Leu Ser Cys Arg Ala Gln Gly Gln Thr Gly Val Leu Thr Val 
    530                 535                 540                 


His Ser Tyr Ala Lys Gly Asp Gly Arg Val Thr Val Gly Glu Pro Cys 
545                 550                 555                 560 


Thr Arg Lys Lys Gly Ser Ala Ala Arg Ser Phe Ser Glu Arg Glu Leu 
                565                 570                 575     


Ala Glu Val Ala Asp Glu Tyr Met Phe Ser Leu Glu Glu Asn Lys Lys 
            580                 585                 590         


Ser Lys Gly Arg Arg Gln Pro Leu Ser Lys Leu Pro Arg His His Pro 
        595                 600                 605             


Leu Val Leu Gln Glu Cys Val Ser Asp Asp Glu Thr Ser Glu Gln Leu 
    610                 615                 620                 


Thr Pro Glu Glu Glu Ala Glu Glu Thr Glu Ala Trp Ala Lys Pro Leu 
625                 630                 635                 640 


Ser Gln Leu Trp Gln Asn Arg Pro Pro Asn Phe Glu Ala Glu Lys Glu 
                645                 650                 655     


Phe Asn Glu Thr Met Ala Gln Gln Ala Pro His Cys Ala Val Cys Met 
            660                 665                 670         


Ile Phe Gln Thr Tyr His Gln Val Glu Phe Gly Gly Phe Asn Gln Asn 
        675                 680                 685             


Cys Gly Asn Ala Ser Asp Leu Ala Pro Gln Lys Gln Arg Thr Lys Pro 
    690                 695                 700                 


Leu Ile Pro Glu Met Cys Phe Thr Ser Thr Gly Cys Ser Thr Asp Ile 
705                 710                 715                 720 


Asn Leu Ser Thr Pro Tyr Leu Glu Glu Asp Gly Thr Ser Ile Leu Val 
                725                 730                 735     


Ser Cys Lys Lys Cys Ser Val Arg Val His Ala Ser Cys Tyr Gly Val 
            740                 745                 750         


Pro Pro Ala Lys Ala Ser Glu Asp Trp Met Cys Ser Arg Cys Ser Ala 
        755                 760                 765             


Asn Ala Leu Glu Glu Asp Cys Cys Leu Cys Ser Leu Arg Gly Gly Ala 
    770                 775                 780                 


Leu Gln Arg Ala Asn Asp Asp Arg Trp Val His Val Ser Cys Ala Val 
785                 790                 795                 800 


Ala Ile Leu Glu Ala Arg Phe Val Asn Ile Ala Glu Arg Ser Pro Val 
                805                 810                 815     


Asp Val Ser Lys Ile Pro Leu Pro Arg Phe Lys Leu Lys Cys Ile Phe 
            820                 825                 830         


Cys Lys Lys Arg Arg Lys Arg Thr Ala Gly Cys Cys Val Gln Cys Ser 
        835                 840                 845             


His Gly Arg Cys Pro Thr Ala Phe His Val Ser Cys Ala Gln Ala Ala 
    850                 855                 860                 


Gly Val Met Met Gln Pro Asp Asp Trp Pro Phe Val Val Phe Ile Thr 
865                 870                 875                 880 


Cys Phe Arg His Lys Ile Pro Asn Leu Glu Arg Ala Lys Gly Ala Leu 
                885                 890                 895     


Gln Ser Ile Thr Ala Gly Gln Lys Val Ile Ser Lys His Lys Asn Gly 
            900                 905                 910         


Arg Phe Tyr Gln Cys Glu Val Val Arg Leu Thr Thr Glu Thr Phe Tyr 
        915                 920                 925             


Glu Val Asn Phe Asp Asp Gly Ser Phe Ser Asp Asn Leu Tyr Pro Glu 
    930                 935                 940                 


Asp Ile Val Ser Gln Asp Cys Leu Gln Phe Gly Pro Pro Ala Glu Gly 
945                 950                 955                 960 


Glu Val Val Gln Val Arg Trp Thr Asp Gly Gln Val Tyr Gly Ala Lys 
                965                 970                 975     


Phe Val Ala Ser His Pro Ile Gln Met Tyr Gln Val Glu Phe Glu Asp 
            980                 985                 990         


Gly Ser Gln Leu Val Val Lys Arg  Asp Asp Val Tyr Thr  Leu Asp Glu 
        995                 1000                 1005             


Glu Leu  Pro Lys Arg Val Lys  Ser Arg Leu Ser Val  Ala Ser Asp 
    1010                 1015                 1020             


Met Arg  Phe Asn Glu Ile Phe  Thr Glu Lys Glu Val  Lys Gln Glu 
    1025                 1030                 1035             


Lys Lys  Arg Gln Arg Val Ile  Asn Ser Arg Tyr Arg  Glu Asp Tyr 
    1040                 1045                 1050             


Ile Glu  Pro Ala Leu Tyr Arg  Ala Ile Met Glu 
    1055                 1060                 


<210> 3
<211> 2339
<212> DNA
<213> Homo sapiens

<400> 3
cctgtggtcc cgggtttctg cagagtctac ttcagaagcg gaggcactgg gagtccggtt       60

tgggattgcc aggctgtggt tgtgagtctg agcttgtgag cggctgtggc gccccaactc      120

ttcgccagca tatcatcccg gcaggcgata aactacattc agttgagtct gcaagactgg      180

gaggaactgg ggtgataaga aatctattca ctgtcaaggt ttattgaagt caaaatgtcc      240

aaaaaaatca gtggcggttc tgtggtagag atgcaaggag atgaaatgac acgaatcatt      300

tgggaattga ttaaagagaa actcattttt ccctacgtgg aattggatct acatagctat      360

gatttaggca tagagaatcg tgatgccacc aacgaccaag tcaccaagga tgctgcagaa      420

gctataaaga agcataatgt tggcgtcaaa tgtgccacta tcactcctga tgagaagagg      480

gttgaggagt tcaagttgaa acaaatgtgg aaatcaccaa atggcaccat acgaaatatt      540

ctgggtggca cggtcttcag agaagccatt atctgcaaaa atatcccccg gcttgtgagt      600

ggatgggtaa aacctatcat cataggtcgt catgcttatg gggatcaata cagagcaact      660

gattttgttg ttcctgggcc tggaaaagta gagataacct acacaccaag tgacggaacc      720

caaaaggtga catacctggt acataacttt gaagaaggtg gtggtgttgc catggggatg      780

tataatcaag ataagtcaat tgaagatttt gcacacagtt ccttccaaat ggctctgtct      840

aagggttggc ctttgtatct gagcaccaaa aacactattc tgaagaaata tgatgggcgt      900

tttaaagaca tctttcagga gatatatgac aagcagtaca agtcccagtt tgaagctcaa      960

aagatctggt atgagcatag gctcatcgac gacatggtgg cccaagctat gaaatcagag     1020

ggaggcttca tctgggcctg taaaaactat gatggtgacg tgcagtcgga ctctgtggcc     1080

caagggtatg gctctctcgg catgatgacc agcgtgctgg tttgtccaga tggcaagaca     1140

gtagaagcag aggctgccca cgggactgta acccgtcact accgcatgta ccagaaagga     1200

caggagacgt ccaccaatcc cattgcttcc atttttgcct ggaccagagg gttagcccac     1260

agagcaaagc ttgataacaa taaagagctt gccttctttg caaatgcttt ggaagaagtc     1320

tctattgaga caattgaggc tggcttcatg accaaggact tggctgcttg cattaaaggt     1380

ttacccaatg tgcaacgttc tgactacttg aatacatttg agttcatgga taaacttgga     1440

gaaaacttga agatcaaact agctcaggcc aaactttaag ttcatacctg agctaagaag     1500

gataattgtc ttttggtaac taggtctaca ggtttacatt tttctgtgtt acactcaagg     1560

ataaaggcaa aatcaatttt gtaatttgtt tagaagccag agtttatctt ttctataagt     1620

ttacagcctt tttcttatat atacagttat tgccaccttt gtgaacatgg caagggactt     1680

ttttacaatt tttattttat tttctagtac cagcctagga attcggttag tactcatttg     1740

tattcactgt cactttttct catgttctaa ttataaatga ccaaaatcaa gattgctcaa     1800

aagggtaaat gatagccaca gtattgctcc ctaaaatatg cataaagtag aaattcactg     1860

ccttcccctc ctgtccatga ccttgggcac agggaagttc tggtgtcata gatatcccgt     1920

tttgtgaggt agagctgtgc attaaacttg cacatgactg gaacgaagta tgagtgcaac     1980

tcaaatgtgt tgaagatact gcagtcattt ttgtaaagac cttgctgaat gtttccaata     2040

gactaaatac tgtttaggcc gcaggagagt ttggaatccg gaataaatac tacctggagg     2100

tttgtcctct ccatttttct ctttctcctc ctggcctggc ctgaatatta tactactcta     2160

aatagcatat ttcatccaag tgcaataatg taagctgaat cttttttgga cttctgctgg     2220

cctgttttat ttcttttata taaatgtgat ttctcagaaa ttgatattaa acactatctt     2280

atcttctcct gaactgttga ttttaattaa aattaagtgc taattaccaa aaaaaaaaa      2339


<210> 4
<211> 414
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


<210> 5
<211> 5675
<212> DNA
<213> Homo sapiens

<400> 5
agggctcggt cgccagcaac cgagcggggc ccggcccgag cggggcctgg gggtgcgacg       60

ccgagggcgg gggagagcgc gccgctgctc ccggaccggg ccgcgcacgc cgcctcagga      120

accatcactg ttgctggagg cacctgacaa atcctagcga atttttggag catctccacc      180

caggaacctc gccatccaga agtgtgcttc ccgcacagct gcagccatgg ggtctgagga      240

ccacggcgcc cagaacccca gctgtaaaat catgacgttt cgcccaacca tggaagaatt      300

taaagacttc aacaaatacg tggcctacat agagtcgcag ggagcccacc gggcgggcct      360

ggccaagatc atccccccga aggagtggaa gccgcggcag acgtatgatg acatcgacga      420

cgtggtgatc ccggcgccca tccagcaggt ggtgacgggc cagtcgggcc tcttcacgca      480

gtacaatatc cagaagaagg ccatgacagt gggcgagtac cgccgcctgg ccaacagcga      540

gaagtactgt accccgcggc accaggactt tgatgacctt gaacgcaaat actggaagaa      600

cctcaccttt gtctccccga tctacggggc tgacatcagc ggctctttgt atgatgacga      660

cgtggcccag tggaacatcg ggagcctccg gaccatcctg gacatggtgg agcgcgagtg      720

cggcaccatc atcgagggcg tgaacacgcc ctacctgtac ttcggcatgt ggaagaccac      780

cttcgcctgg cacaccgagg acatggacct gtacagcatc aactacctgc actttgggga      840

gcctaagtcc tggtacgcca tcccaccaga gcacggcaag cgcctggagc ggctggccat      900

cggcttcttc cccgggagct cgcagggctg cgacgccttc ctgcggcata agatgaccct      960

catctcgccc atcatcctga agaagtacgg gatccccttc agccggatca cgcaggaggc     1020

cggggaattc atgatcacat ttccctacgg ctaccacgcc ggcttcaatc acgggttcaa     1080

ctgcgcagaa tctaccaact tcgccaccct gcggtggatt gactacggca aagtggccac     1140

tcagtgcacg tgccggaagg acatggtcaa gatctccatg gacgtgttcg tgcgcatcct     1200

gcagcccgag cgctacgagc tgtggaagca gggcaaggac ctcacggtgc tggaccacac     1260

gcggcccacg gcgctcacca gccccgagct gagctcctgg agtgcatccc gggcctcgct     1320

gaaggccaag ctcctccgca ggtctcaccg gaaacggagc cagcccaaga agccgaagcc     1380

cgaagacccc aagttccctg gggagggtac ggctggggca gcgctcctag aggaggctgg     1440

gggcagcgtg aaggaggagg ctgggccgga ggttgacccc gaggaggagg aggaggagcc     1500

gcagccactg ccacacggcc gggaggccga gggcgcagaa gaggacggga ggggcaagct     1560

gcggccaacc aaggccaaga gcgagcggaa gaagaagagc ttcggcctgc tgcccccaca     1620

gctgccgccc ccgcctgctc acttcccctc agaggaggcg ctgtggctgc catccccact     1680

ggagcccccg gtgctgggcc caggccctgc agccatggag gagagccccc tgccggcacc     1740

ccttaatgtc gtgccccctg aggtgcccag tgaggagcta gaggccaagc ctcggcccat     1800

catccccatg ctgtacgtgg tgccgcggcc gggcaaggca gccttcaacc aggagcacgt     1860

gtcctgccag caggcctttg agcactttgc ccagaagggt ccgacctgga aggaaccagt     1920

ttcccccatg gagctgacgg ggccagagga cggtgcagcc agcagtgggg caggtcgcat     1980

ggagaccaaa gcccgggccg gagaggggca ggcaccgtcc acattttcca aattgaagat     2040

ggagatcaag aagagccggc gccatcccct gggccggccg cccacccggt ccccactgtc     2100

ggtggtgaag caggaggcct caagtgacga ggaggcatcc cctttctccg gggaggaaga     2160

tgtgagtgac ccggacgcct tgaggccgct gctgtctctg cagtggaaga acagggcggc     2220

cagcttccag gccgagagga agttcaacgc agcggctgcg cgcacggagc cctactgcgc     2280

catctgcacg ctcttctacc cctactgcca ggccctacag actgagaagg aggcacccat     2340

agcctccctc ggagagggct gcccggccac attaccctcc aaaagccgtc agaagacccg     2400

accgctcatc cctgagatgt gcttcacctc tggcggtgag aacacggagc cgctgcctgc     2460

caactcctac atcggcgacg acgggaccag ccccctgatc gcctgcggca agtgctgcct     2520

gcaggtccat gccagttgct atggcatccg tcccgagctg gtcaatgaag gctggacgtg     2580

ttcccggtgc gcggcccacg cctggactgc ggagtgctgc ctgtgcaacc tgcgaggagg     2640

tgcgctgcag atgaccaccg ataggaggtg gatccacgtg atctgtgcca tcgcagtccc     2700

cgaggcgcgc ttcctgaacg tgattgagcg ccaccctgtg gacatcagcg ccatccccga     2760

gcagcggtgg aagctgaaat gcgtgtactg ccggaagcgg atgaagaagg tgtcaggtgc     2820

ctgtatccag tgctcctacg agcactgctc cacgtccttc cacgtgacct gcgcccacgc     2880

cgcaggcgtg ctcatggagc cggacgactg gccctatgtg gtctccatca cctgcctcaa     2940

gcacaagtcg gggggtcacg ctgtccaact cctgagggcc gtgtccctag gccaggtggt     3000

catcaccaag aaccgcaacg ggctgtacta ccgctgtcgc gtcatcggtg ccgcctcgca     3060

gacctgctac gaagtgaact tcgacgatgg ctcctacagc gacaacctgt accctgagag     3120

catcacgagt agggactgtg tccagctggg acccccttcc gagggggagc tggtggagct     3180

ccggtggact gacggcaacc tctacaaggc caagttcatc tcctccgtca ccagccacat     3240

ctaccaggtg gagtttgagg acgggtccca gctgacggtg aagcgtgggg acatcttcac     3300

cctggaggag gagctgccca agagggtccg ctctcggctg tcactgagca cgggggcacc     3360

gcaggagccc gccttctcgg gggaggaggc caaggccgcc aagcgcccgc gtgtgggcac     3420

cccgcttgcc acggaggact ccgggcggag ccaggactac gtggccttcg tggagagcct     3480

cctgcaggtg cagggccggc ccggagcccc cttctaggac agctggccgc tcaggcgacc     3540

ctcagcccgg cggggaggcc atggcatgcc ccgggcgttc gcttgctgtg aattcctgtc     3600

ctcgtgtccc cgacccccga gaggccacct ccaagccgcg ggtgccccct agggcgacag     3660

gagccagcgg gacgccgcac gcggccccag actcagggag cagggccagg cgggctcggg     3720

ggccggccag gggagcaccc cactcaacta ctcagaattt taaaccatgt aagctctctt     3780

cttctcgaaa aggtgctact gcaatgccct actgagcaac ctttgagatt gtcacttctg     3840

tacataaacc acctttgtga ggctctttct ataaatacat attgtttaaa aaaaagcaag     3900

aaaaaaagga aaacaaagga aaatatcccc aaagttgttt tctagatttg tggctttaag     3960

aaaaacaaaa caaaacaaac acattgtttt tctcagaacc aggattctct gagaggtcag     4020

agcatctcgc tgtttttttg ttgttgtttt aaaatattat gatttggcta cagaccaggc     4080

agggaaagag acccggtaat tggagggtga gcctcggggg gggggcagga cgccccggtt     4140

tcggcacagc ccggtcactc acggcctcgc tctcgcctca ccccggctcc tgggctttga     4200

tggtctggtg ccagtgcctg tgcccactct gtgcctgctg ggaggaggcc caggctctct     4260

ggtggccgcc cctgtgcacc tggccagggg aagcccgggg gtctggggcc tccctccgtc     4320

tgcgcccacc tttgcagaat aaactctctc ctggggtttg tctatctttg tttctctcac     4380

ctgagagaaa cgcaggtgtt ccagaggctt ccttgcagac aaagcacccc tgcacctcct     4440

atggctcagg atgagggagg cccccaggcc cttctggttg gtagtgagtg tggacagctt     4500

cccagctctt cgggtacaac cctgagcagg tcgggggaca cagggccgag gcaggccttc     4560

ggggcccctt tcgcctgctt ccgggcaggg acgaggcctg gtgtcctcgc tccacccacc     4620

cacgctgctg tcacctgagg ggaatctgct tcttaggagt gggttgagct gatagagaaa     4680

aaacggcctt cagcccaggc tgggaagcgc cttctccagg tgcctctccc tcaccagctc     4740

tgcacccctc tggggagcct tccccacctt agctgtctcc tgccccaggg agggatggag     4800

gagataattt gcttatatta aaaacaaaaa atggctgagg caggagtttg ggaccagcct     4860

gggctatata gcaagacccc atcactacaa attttttaca aattagctag gtgtggtggt     4920

gcgcacctgt ggtcccagct actcgggagg ctgtggtggg aggattgctt gagtccagga     4980

ggttgaggct gcagtcagct cagattgcac cactgcactc cagcctgggc aacagagcga     5040

gaccctgtct ccaaaaaaaa aaaaaagcaa tgtttatatt ataaaagagt gtcctaacag     5100

tccccgggct agagaggact aaggaaaaca gagagagtgt tacgcaggag caagcctttc     5160

atttccttgg tgggggaggg gggcggttgc cctggagagg gccggggtcg gggaggttgg     5220

ggggtgtcag ccaaaacgtg gaggtgtccc tctgcacgca gccctcgccc ggcgtggcgc     5280

tgacactgta ttcttatgtt gtttgaaaat gctatttata ttgtaaagaa gcgggcgggt     5340

gcccctgctg cccttgtccc ttgggggtca cacccatccc ctggtgggct cctgggcggc     5400

ctgcgcagat gggccacaga agggcaggcc ggagctgcac actctcccca cgaaggtatc     5460

tctgtgtctt actctgtgca aagacgcggc aaaacccagt gccctggttt ttccccaccc     5520

gagatgaagg atacgctgta ttttttgcct aatgtccctg cctctaggtt cataatgaat     5580

taaaggttca tgaacgctgc gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                5675


<210> 6
<211> 1096
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Ser Glu Asp His Gly Ala Gln Asn Pro Ser Cys Lys Ile Met 
1               5                   10                  15      


Thr Phe Arg Pro Thr Met Glu Glu Phe Lys Asp Phe Asn Lys Tyr Val 
            20                  25                  30          


Ala Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Ile 
        35                  40                  45              


Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Thr Tyr Asp Asp Ile Asp 
    50                  55                  60                  


Asp Val Val Ile Pro Ala Pro Ile Gln Gln Val Val Thr Gly Gln Ser 
65                  70                  75                  80  


Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Gly 
                85                  90                  95      


Glu Tyr Arg Arg Leu Ala Asn Ser Glu Lys Tyr Cys Thr Pro Arg His 
            100                 105                 110         


Gln Asp Phe Asp Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe 
        115                 120                 125             


Val Ser Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu Tyr Asp Asp 
    130                 135                 140                 


Asp Val Ala Gln Trp Asn Ile Gly Ser Leu Arg Thr Ile Leu Asp Met 
145                 150                 155                 160 


Val Glu Arg Glu Cys Gly Thr Ile Ile Glu Gly Val Asn Thr Pro Tyr 
                165                 170                 175     


Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu Asp 
            180                 185                 190         


Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser 
        195                 200                 205             


Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala 
    210                 215                 220                 


Ile Gly Phe Phe Pro Gly Ser Ser Gln Gly Cys Asp Ala Phe Leu Arg 
225                 230                 235                 240 


His Lys Met Thr Leu Ile Ser Pro Ile Ile Leu Lys Lys Tyr Gly Ile 
                245                 250                 255     


Pro Phe Ser Arg Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe 
            260                 265                 270         


Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu 
        275                 280                 285             


Ser Thr Asn Phe Ala Thr Leu Arg Trp Ile Asp Tyr Gly Lys Val Ala 
    290                 295                 300                 


Thr Gln Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val 
305                 310                 315                 320 


Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Glu Leu Trp Lys Gln Gly 
                325                 330                 335     


Lys Asp Leu Thr Val Leu Asp His Thr Arg Pro Thr Ala Leu Thr Ser 
            340                 345                 350         


Pro Glu Leu Ser Ser Trp Ser Ala Ser Arg Ala Ser Leu Lys Ala Lys 
        355                 360                 365             


Leu Leu Arg Arg Ser His Arg Lys Arg Ser Gln Pro Lys Lys Pro Lys 
    370                 375                 380                 


Pro Glu Asp Pro Lys Phe Pro Gly Glu Gly Thr Ala Gly Ala Ala Leu 
385                 390                 395                 400 


Leu Glu Glu Ala Gly Gly Ser Val Lys Glu Glu Ala Gly Pro Glu Val 
                405                 410                 415     


Asp Pro Glu Glu Glu Glu Glu Glu Pro Gln Pro Leu Pro His Gly Arg 
            420                 425                 430         


Glu Ala Glu Gly Ala Glu Glu Asp Gly Arg Gly Lys Leu Arg Pro Thr 
        435                 440                 445             


Lys Ala Lys Ser Glu Arg Lys Lys Lys Ser Phe Gly Leu Leu Pro Pro 
    450                 455                 460                 


Gln Leu Pro Pro Pro Pro Ala His Phe Pro Ser Glu Glu Ala Leu Trp 
465                 470                 475                 480 


Leu Pro Ser Pro Leu Glu Pro Pro Val Leu Gly Pro Gly Pro Ala Ala 
                485                 490                 495     


Met Glu Glu Ser Pro Leu Pro Ala Pro Leu Asn Val Val Pro Pro Glu 
            500                 505                 510         


Val Pro Ser Glu Glu Leu Glu Ala Lys Pro Arg Pro Ile Ile Pro Met 
        515                 520                 525             


Leu Tyr Val Val Pro Arg Pro Gly Lys Ala Ala Phe Asn Gln Glu His 
    530                 535                 540                 


Val Ser Cys Gln Gln Ala Phe Glu His Phe Ala Gln Lys Gly Pro Thr 
545                 550                 555                 560 


Trp Lys Glu Pro Val Ser Pro Met Glu Leu Thr Gly Pro Glu Asp Gly 
                565                 570                 575     


Ala Ala Ser Ser Gly Ala Gly Arg Met Glu Thr Lys Ala Arg Ala Gly 
            580                 585                 590         


Glu Gly Gln Ala Pro Ser Thr Phe Ser Lys Leu Lys Met Glu Ile Lys 
        595                 600                 605             


Lys Ser Arg Arg His Pro Leu Gly Arg Pro Pro Thr Arg Ser Pro Leu 
    610                 615                 620                 


Ser Val Val Lys Gln Glu Ala Ser Ser Asp Glu Glu Ala Ser Pro Phe 
625                 630                 635                 640 


Ser Gly Glu Glu Asp Val Ser Asp Pro Asp Ala Leu Arg Pro Leu Leu 
                645                 650                 655     


Ser Leu Gln Trp Lys Asn Arg Ala Ala Ser Phe Gln Ala Glu Arg Lys 
            660                 665                 670         


Phe Asn Ala Ala Ala Ala Arg Thr Glu Pro Tyr Cys Ala Ile Cys Thr 
        675                 680                 685             


Leu Phe Tyr Pro Tyr Cys Gln Ala Leu Gln Thr Glu Lys Glu Ala Pro 
    690                 695                 700                 


Ile Ala Ser Leu Gly Glu Gly Cys Pro Ala Thr Leu Pro Ser Lys Ser 
705                 710                 715                 720 


Arg Gln Lys Thr Arg Pro Leu Ile Pro Glu Met Cys Phe Thr Ser Gly 
                725                 730                 735     


Gly Glu Asn Thr Glu Pro Leu Pro Ala Asn Ser Tyr Ile Gly Asp Asp 
            740                 745                 750         


Gly Thr Ser Pro Leu Ile Ala Cys Gly Lys Cys Cys Leu Gln Val His 
        755                 760                 765             


Ala Ser Cys Tyr Gly Ile Arg Pro Glu Leu Val Asn Glu Gly Trp Thr 
    770                 775                 780                 


Cys Ser Arg Cys Ala Ala His Ala Trp Thr Ala Glu Cys Cys Leu Cys 
785                 790                 795                 800 


Asn Leu Arg Gly Gly Ala Leu Gln Met Thr Thr Asp Arg Arg Trp Ile 
                805                 810                 815     


His Val Ile Cys Ala Ile Ala Val Pro Glu Ala Arg Phe Leu Asn Val 
            820                 825                 830         


Ile Glu Arg His Pro Val Asp Ile Ser Ala Ile Pro Glu Gln Arg Trp 
        835                 840                 845             


Lys Leu Lys Cys Val Tyr Cys Arg Lys Arg Met Lys Lys Val Ser Gly 
    850                 855                 860                 


Ala Cys Ile Gln Cys Ser Tyr Glu His Cys Ser Thr Ser Phe His Val 
865                 870                 875                 880 


Thr Cys Ala His Ala Ala Gly Val Leu Met Glu Pro Asp Asp Trp Pro 
                885                 890                 895     


Tyr Val Val Ser Ile Thr Cys Leu Lys His Lys Ser Gly Gly His Ala 
            900                 905                 910         


Val Gln Leu Leu Arg Ala Val Ser Leu Gly Gln Val Val Ile Thr Lys 
        915                 920                 925             


Asn Arg Asn Gly Leu Tyr Tyr Arg Cys Arg Val Ile Gly Ala Ala Ser 
    930                 935                 940                 


Gln Thr Cys Tyr Glu Val Asn Phe Asp Asp Gly Ser Tyr Ser Asp Asn 
945                 950                 955                 960 


Leu Tyr Pro Glu Ser Ile Thr Ser Arg Asp Cys Val Gln Leu Gly Pro 
                965                 970                 975     


Pro Ser Glu Gly Glu Leu Val Glu Leu Arg Trp Thr Asp Gly Asn Leu 
            980                 985                 990         


Tyr Lys Ala Lys Phe Ile Ser Ser  Val Thr Ser His Ile  Tyr Gln Val 
        995                 1000                 1005             


Glu Phe  Glu Asp Gly Ser Gln  Leu Thr Val Lys Arg  Gly Asp Ile 
    1010                 1015                 1020             


Phe Thr  Leu Glu Glu Glu Leu  Pro Lys Arg Val Arg  Ser Arg Leu 
    1025                 1030                 1035             


Ser Leu  Ser Thr Gly Ala Pro  Gln Glu Pro Ala Phe  Ser Gly Glu 
    1040                 1045                 1050             


Glu Ala  Lys Ala Ala Lys Arg  Pro Arg Val Gly Thr  Pro Leu Ala 
    1055                 1060                 1065             


Thr Glu  Asp Ser Gly Arg Ser  Gln Asp Tyr Val Ala  Phe Val Glu 
    1070                 1075                 1080             


Ser Leu  Leu Gln Val Gln Gly  Arg Pro Gly Ala Pro  Phe 
    1085                 1090                 1095     


<210> 7
<211> 4687
<212> DNA
<213> Homo sapiens

<400> 7
gccataggtg cgcgtcggcg cccaggagga cgtgtggcgc gtggactaca tcaggtccag       60

ccctgcggga ccccagccag cgcttccggg caaggttctg tgcacctgtt ttctccttct      120

acgcgagtat ctttcccctc cggaaagaat gggatatgcc tgtgtccaaa ggacaagaag      180

atgcgcgcca gcaagcctaa gttaaccaca gcgcggaagt tgagcccaaa gcaagagcgt      240

gccgggcacc tttaagctgt ttgtaagccc acgtgactca ccaagtgcgg gccccagcgg      300

tcacgtgacg gcgcgcgcgc cctcgcgcag ggagagccgg cggtgcgcgc gccttcgccg      360

ctgcctccca cccaccccct cgacgggagg gtgaggcgcg gcgcagtgat cgggcggccg      420

gggtcctgtg cgcgtgcgca gcgaacagct gtcacctagt gcggaacaag tctcccaaat      480

ttcccaaatc tccctgggcc ggaggccact gtcttctctt cctcctccac cgagtcgtgc      540

tctcgcccca acccgcgcgc cagacactgc cctaaccatc atggaggtgg ccgaggtgga      600

aagtcctctg aaccccagct gtaagataat gaccttcaga ccctccatgg aggagttccg      660

ggagttcaac aaataccttg catacatgga gtctaaagga gcccatcgtg cgggtcttgc      720

aaaggtgatt cctcctaagg agtggaagcc aagacagtgc tatgatgaca ttgataattt      780

gctcattcca gcaccaattc agcagatggt cacagggcag tcaggactgt tcactcagta      840

caacatccag aaaaaagcga tgactgtgaa ggagttcagg cagctggcca acagtggcaa      900

atattgtact ccaagatact tggattacga agatttggag cgcaagtact ggaagaactt      960

aacttttgtg gcacctatct atggtgcaga tattaatggg agcatatatg atgagggtgt     1020

ggatgaatgg aacatagctc gcctcaatac agtcttggat gtggttgaag aagagtgtgg     1080

catttctatt gagggtgtaa ataccccata tctctatttt ggcatgtgga agaccacgtt     1140

tgcatggcac accgaagaca tggacctcta tagcattaat tatctccact ttggagagcc     1200

caagtcttgg tatgctatac ctccggagca tggaaaacga cttgaaagac tagctcaagg     1260

ttttttccca agcagctccc aagggtgtga tgcatttctt cgccacaaga tgacattgat     1320

ttctccatca gtattgaaga aatatggtat tccctttgac aagataaccc aggaggctgg     1380

agaattcatg atcactttcc catatggcta ccatgctggt tttaatcatg gtttcaactg     1440

tgcagaatct acaaattttg ctactgtcag atggattgac tatggaaaag ttgccaaatt     1500

gtgcacttgc aggaaagaca tggtgaagat ttcaatggat atctttgtga ggaaatttca     1560

gccagacaga tatcagcttt ggaaacaagg aaaggatata tacaccattg atcacacgaa     1620

gcctactcca gcatccaccc ctgaagtaaa agcatggctg cagaggagga ggaaagtaag     1680

aaaagcatcc cgaagcttcc agtgtgctag gtctacctct aaaaggccta aggctgatga     1740

ggaagaggaa gtgtcagatg aagtcgatgg ggcagaggtc cctaaccccg actcagtcac     1800

agatgacctc aaggtcagtg aaaagtcaga agcagcagtg aagctgagga acacagaagc     1860

atcttcagaa gaagagtcat ctgctagcag gatgcaggtg gagcagaatt tatcagatca     1920

tatcaaactc tcaggaaaca gctgcttaag tacatctgta acagaagaca taaaaactga     1980

ggatgacaaa gcttatgcat atagaagtgt accttctata tccagtgagg ctgatgattc     2040

cattccattg tctagtggct atgagaagcc cgagaaatca gacccatccg agctttcatg     2100

gccaaagtca cctgagtcat gctcatcagt ggcagagagt aatggtgtgt taacagaggg     2160

agaagagagt gatgtggaga gccatgggaa tggccttgaa cctggggaaa tcccagcggt     2220

ccccagtgga gagagaaata gcttcaaagt ccccagtata gcagagggag agaacaaaac     2280

ctctaagagt tggcgccatc cacttagcag gcctccagca agatctccga tgactcttgt     2340

gaagcagcag gcgccaagtg atgaagaatt gcctgaggtt ctgtccattg aggaggaagt     2400

ggaagaaaca gagtcttggg cgaaacctct catccacctt tggcagacga agtcccctaa     2460

cttcgcagct gagcaagagt ataatgcaac agtggccagg atgaagccac actgtgccat     2520

ctgcactctg ctcatgccgt accacaagcc agatagcagc aatgaagaaa atgatgctag     2580

atgggagaca aaattagatg aagtcgttac atcggaggga aagactaagc ccctcatacc     2640

agagatgtgt tttatttata gtgaagaaaa tatagaatat tctccaccca atgccttcct     2700

tgaagaggat ggaacaagtc tccttatttc ctgtgcaaag tgctgcgtac gggttcatgc     2760

aagttgttat ggtattcctt ctcatgagat ctgtgatgga tggctgtgtg cccggtgcaa     2820

aagaaatgcg tggacagcag aatgctgtct ctgcaatttg agaggaggtg ctcttaagca     2880

aacgaagaac aataagtggg cccatgtcat gtgcgccgtt gcggtcccag aagttcgatt     2940

cactaatgtc ccagaaagga cacaaataga tgtaggcaga atacctttac agaggttaaa     3000

attgaaatgc atcttctgca gacaccgggt taagagggtc tctggagcct gcatccagtg     3060

ttcctacggt cgctgcccgg cctccttcca tgtcacttgt gcccatgctg ctggggtact     3120

gatggagcct gatgactggc cttatgtggt gaacattaca tgctttcgac ataaggtcaa     3180

ccccaacgtg aagtccaagg cttgcgagaa ggtcatttcc gtgggtcaaa cggtcatcac     3240

gaagcatcgg aacacccggt attacagttg cagagtgatg gctgtgacat cgcagacctt     3300

ctatgaggtc atgtttgatg atggctcctt tagcagagac acatttcctg aggatatcgt     3360

gagccgagac tgtctgaagc tgggcccacc tgctgaggga gaagtcgtcc aagtcaagtg     3420

gcccgatggc aaactctatg gagcaaaata ttttggatca aatattgccc acatgtacca     3480

ggttgagttt gaagatggat cccagatagc aatgaagaga gaggacatct acactttaga     3540

tgaagagtta cccaagagag tgaaagctcg attttccaca gcctctgaca tgcgatttga     3600

agacacgttt tatggagcag acattatcca aggggagaga aagagacaaa gagtgctgag     3660

ctccaggttt aagaatgaat atgtggccga ccctgtatac cgcacttttt tgaagagctc     3720

tttccagaag aagtgccaga agagacagta gtctgcatac atcgctgcag gccacagagc     3780

agcttgggtt ggaagagaga agatgaaggg acatccttgg ggctgtgccg tgagttttgc     3840

tggcataggt gacagggtgt gtctctgaca gtggtaaatc gggtttccag agtttggtca     3900

ccaaaaatac aaaatacacc caatgaattg gacgcagcaa tctgaaatca tctctagtct     3960

tgctttcact tgtgagcagt tgtcttctat gatcccaaag aagttttcta agtgaaagga     4020

aatactagtg aatcacccac aaggaaaagc cactgccaca gaggaggcgg gtccccttgt     4080

gcggcttagg gccctgtcag gaaacacacg gggacctctc tctctagctc cagcaggtgg     4140

cacctcggta cccagcgggt agggcgataa tttatatatt ttccacagtc agggaaggac     4200

tctcacttat ttgtttcaaa ttgcagtttt tataaaacat ttttaaaaca caaatggcat     4260

gtatgctaat gagatttacc cgtgtgctat ctgtatttcc cttgtacaga acttttacat     4320

ttttgaatat tcctattact tttgattgtg tctgatggga actgagttgt tggcctttgt     4380

gaaatgaaat ttttggctct tgagaaagaa ttcttatgaa ttgttatgcg aattttatat     4440

atttaaagag ggagatctgg ggctgttatt tttaaacact ttttttcata atacatattc     4500

cgagtagata tttataaaat atatgtttct ttcattatgt gtttgtaaaa ttagagttta     4560

aataaatatg ctttgatgca tagttttgaa ctaatgtaac atgatttttc ttttttaaaa     4620

cagcctgaaa atgtactagt gtttaaaaat aaagatttcc attttctcca aaaaaaaaaa     4680

aaaaaaa                                                               4687


<210> 8
<211> 1056
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Val Ala Glu Val Glu Ser Pro Leu Asn Pro Ser Cys Lys Ile 
1               5                   10                  15      


Met Thr Phe Arg Pro Ser Met Glu Glu Phe Arg Glu Phe Asn Lys Tyr 
            20                  25                  30          


Leu Ala Tyr Met Glu Ser Lys Gly Ala His Arg Ala Gly Leu Ala Lys 
        35                  40                  45              


Val Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Cys Tyr Asp Asp Ile 
    50                  55                  60                  


Asp Asn Leu Leu Ile Pro Ala Pro Ile Gln Gln Met Val Thr Gly Gln 
65                  70                  75                  80  


Ser Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val 
                85                  90                  95      


Lys Glu Phe Arg Gln Leu Ala Asn Ser Gly Lys Tyr Cys Thr Pro Arg 
            100                 105                 110         


Tyr Leu Asp Tyr Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr 
        115                 120                 125             


Phe Val Ala Pro Ile Tyr Gly Ala Asp Ile Asn Gly Ser Ile Tyr Asp 
    130                 135                 140                 


Glu Gly Val Asp Glu Trp Asn Ile Ala Arg Leu Asn Thr Val Leu Asp 
145                 150                 155                 160 


Val Val Glu Glu Glu Cys Gly Ile Ser Ile Glu Gly Val Asn Thr Pro 
                165                 170                 175     


Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu 
            180                 185                 190         


Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys 
        195                 200                 205             


Ser Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu 
    210                 215                 220                 


Ala Gln Gly Phe Phe Pro Ser Ser Ser Gln Gly Cys Asp Ala Phe Leu 
225                 230                 235                 240 


Arg His Lys Met Thr Leu Ile Ser Pro Ser Val Leu Lys Lys Tyr Gly 
                245                 250                 255     


Ile Pro Phe Asp Lys Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr 
            260                 265                 270         


Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala 
        275                 280                 285             


Glu Ser Thr Asn Phe Ala Thr Val Arg Trp Ile Asp Tyr Gly Lys Val 
    290                 295                 300                 


Ala Lys Leu Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp 
305                 310                 315                 320 


Ile Phe Val Arg Lys Phe Gln Pro Asp Arg Tyr Gln Leu Trp Lys Gln 
                325                 330                 335     


Gly Lys Asp Ile Tyr Thr Ile Asp His Thr Lys Pro Thr Pro Ala Ser 
            340                 345                 350         


Thr Pro Glu Val Lys Ala Trp Leu Gln Arg Arg Arg Lys Val Arg Lys 
        355                 360                 365             


Ala Ser Arg Ser Phe Gln Cys Ala Arg Ser Thr Ser Lys Arg Pro Lys 
    370                 375                 380                 


Ala Asp Glu Glu Glu Glu Val Ser Asp Glu Val Asp Gly Ala Glu Val 
385                 390                 395                 400 


Pro Asn Pro Asp Ser Val Thr Asp Asp Leu Lys Val Ser Glu Lys Ser 
                405                 410                 415     


Glu Ala Ala Val Lys Leu Arg Asn Thr Glu Ala Ser Ser Glu Glu Glu 
            420                 425                 430         


Ser Ser Ala Ser Arg Met Gln Val Glu Gln Asn Leu Ser Asp His Ile 
        435                 440                 445             


Lys Leu Ser Gly Asn Ser Cys Leu Ser Thr Ser Val Thr Glu Asp Ile 
    450                 455                 460                 


Lys Thr Glu Asp Asp Lys Ala Tyr Ala Tyr Arg Ser Val Pro Ser Ile 
465                 470                 475                 480 


Ser Ser Glu Ala Asp Asp Ser Ile Pro Leu Ser Ser Gly Tyr Glu Lys 
                485                 490                 495     


Pro Glu Lys Ser Asp Pro Ser Glu Leu Ser Trp Pro Lys Ser Pro Glu 
            500                 505                 510         


Ser Cys Ser Ser Val Ala Glu Ser Asn Gly Val Leu Thr Glu Gly Glu 
        515                 520                 525             


Glu Ser Asp Val Glu Ser His Gly Asn Gly Leu Glu Pro Gly Glu Ile 
    530                 535                 540                 


Pro Ala Val Pro Ser Gly Glu Arg Asn Ser Phe Lys Val Pro Ser Ile 
545                 550                 555                 560 


Ala Glu Gly Glu Asn Lys Thr Ser Lys Ser Trp Arg His Pro Leu Ser 
                565                 570                 575     


Arg Pro Pro Ala Arg Ser Pro Met Thr Leu Val Lys Gln Gln Ala Pro 
            580                 585                 590         


Ser Asp Glu Glu Leu Pro Glu Val Leu Ser Ile Glu Glu Glu Val Glu 
        595                 600                 605             


Glu Thr Glu Ser Trp Ala Lys Pro Leu Ile His Leu Trp Gln Thr Lys 
    610                 615                 620                 


Ser Pro Asn Phe Ala Ala Glu Gln Glu Tyr Asn Ala Thr Val Ala Arg 
625                 630                 635                 640 


Met Lys Pro His Cys Ala Ile Cys Thr Leu Leu Met Pro Tyr His Lys 
                645                 650                 655     


Pro Asp Ser Ser Asn Glu Glu Asn Asp Ala Arg Trp Glu Thr Lys Leu 
            660                 665                 670         


Asp Glu Val Val Thr Ser Glu Gly Lys Thr Lys Pro Leu Ile Pro Glu 
        675                 680                 685             


Met Cys Phe Ile Tyr Ser Glu Glu Asn Ile Glu Tyr Ser Pro Pro Asn 
    690                 695                 700                 


Ala Phe Leu Glu Glu Asp Gly Thr Ser Leu Leu Ile Ser Cys Ala Lys 
705                 710                 715                 720 


Cys Cys Val Arg Val His Ala Ser Cys Tyr Gly Ile Pro Ser His Glu 
                725                 730                 735     


Ile Cys Asp Gly Trp Leu Cys Ala Arg Cys Lys Arg Asn Ala Trp Thr 
            740                 745                 750         


Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly Ala Leu Lys Gln Thr 
        755                 760                 765             


Lys Asn Asn Lys Trp Ala His Val Met Cys Ala Val Ala Val Pro Glu 
    770                 775                 780                 


Val Arg Phe Thr Asn Val Pro Glu Arg Thr Gln Ile Asp Val Gly Arg 
785                 790                 795                 800 


Ile Pro Leu Gln Arg Leu Lys Leu Lys Cys Ile Phe Cys Arg His Arg 
                805                 810                 815     


Val Lys Arg Val Ser Gly Ala Cys Ile Gln Cys Ser Tyr Gly Arg Cys 
            820                 825                 830         


Pro Ala Ser Phe His Val Thr Cys Ala His Ala Ala Gly Val Leu Met 
        835                 840                 845             


Glu Pro Asp Asp Trp Pro Tyr Val Val Asn Ile Thr Cys Phe Arg His 
    850                 855                 860                 


Lys Val Asn Pro Asn Val Lys Ser Lys Ala Cys Glu Lys Val Ile Ser 
865                 870                 875                 880 


Val Gly Gln Thr Val Ile Thr Lys His Arg Asn Thr Arg Tyr Tyr Ser 
                885                 890                 895     


Cys Arg Val Met Ala Val Thr Ser Gln Thr Phe Tyr Glu Val Met Phe 
            900                 905                 910         


Asp Asp Gly Ser Phe Ser Arg Asp Thr Phe Pro Glu Asp Ile Val Ser 
        915                 920                 925             


Arg Asp Cys Leu Lys Leu Gly Pro Pro Ala Glu Gly Glu Val Val Gln 
    930                 935                 940                 


Val Lys Trp Pro Asp Gly Lys Leu Tyr Gly Ala Lys Tyr Phe Gly Ser 
945                 950                 955                 960 


Asn Ile Ala His Met Tyr Gln Val Glu Phe Glu Asp Gly Ser Gln Ile 
                965                 970                 975     


Ala Met Lys Arg Glu Asp Ile Tyr Thr Leu Asp Glu Glu Leu Pro Lys 
            980                 985                 990         


Arg Val Lys Ala Arg Phe Ser Thr  Ala Ser Asp Met Arg  Phe Glu Asp 
        995                 1000                 1005             


Thr Phe  Tyr Gly Ala Asp Ile  Ile Gln Gly Glu Arg  Lys Arg Gln 
    1010                 1015                 1020             


Arg Val  Leu Ser Ser Arg Phe  Lys Asn Glu Tyr Val  Ala Asp Pro 
    1025                 1030                 1035             


Val Tyr  Arg Thr Phe Leu Lys  Ser Ser Phe Gln Lys  Lys Cys Gln 
    1040                 1045                 1050             


Lys Arg  Gln 
    1055     


<210> 9
<211> 2988
<212> DNA
<213> Homo sapiens

<400> 9
aaggggcggg gccgaagcgg cccagggggc gggcgtttga aatcagtgcc ttagagtaga       60

ccctaaacct cattttatac cttcaagaac caattactta atgtctcttc cgtcttttcc      120

gtccccgacc ccctcccaga ctccttcatt ccggtactgc gtggacggaa agccccgggt      180

agccgacacc acgtccccgg ctagcgggag agagcgtgga aaaggattac accaaactgt      240

ttaaatccaa cgactcctgc ttccatcctt tctcctgagc tagaaccaac aaacctagag      300

agttgggctt cggaaaaact agtgttttca tttaattgga tatgaagaaa gaacaaatat      360

gtacggggca accacgatct ttacaaagaa cataagttcc aggaaagcag gaaccttgtc      420

tctcttgttc actgggtgta tcctctgcat atagaacagt gcctggcaca taataggtgc      480

tgaattttgt tctaaacact gaggacattc tctgctacat ttgggtcgta cccccaggtc      540

tgagtaattc aatagactta agaagacaga gcccagcagc aaccgaaaca taacagagtt      600

gcaggatcag ctaacgtcaa tgcctgggca aagctgctgc ccagagtgga atctcactag      660

tgaataaaca agcccaagaa agattatcat ctcatttgca aaaaaaaaag tacgctggta      720

gatcctgcta cctcatagat aacaccagtc aaattttttt ttaaagtagc attttcctac      780

attgtcaact atctagaaca tacctaaaaa ctaagagttt actgcttatt aaatggaaac      840

tatgaagtct aaggccaact gtgcccagaa tccaaattgt aacataatga tatttcatcc      900

aaccaaagaa gagtttaatg attttgataa atatattgct tacatggaat cccaaggtgc      960

acacagagct ggcttggcta agataattcc acccaaagaa tggaaagcca gagagaccta     1020

tgataatatc agtgaaatct taatagccac tcccctccag caggtggcct ctgggcgggc     1080

aggggtgttt actcaatacc ataaaaaaaa gaaagccatg actgtggggg agtatcgcca     1140

tttggcaaac agtaaaaaat atcagactcc accacaccag aatttcgaag atttggagcg     1200

aaaatactgg aagaaccgca tctataattc accgatttat ggtgctgaca tcagtggctc     1260

cttgtttgat gaaaacacta aacaatggaa tcttgggcac ctgggaacaa ttcaggacct     1320

gctggaaaag gaatgtgggg ttgtcataga aggcgtcaat acaccctact tgtactttgg     1380

catgtggaaa accacgtttg cttggcatac agaggacatg gacctttaca gcatcaacta     1440

cctgcacctt ggggagccca aaacttggta tgtggtgccc ccagaacatg gccagcgcct     1500

ggaacgcctg gccagggagc tcttcccagg cagttcccgg ggttgtgggg ccttcctgcg     1560

gcacaaggtg gccctcatct cgcctacagt tctcaaggaa aatgggattc ccttcaatcg     1620

cataactcag gaggctggag agttcatggt gacctttccc tatggctacc atgctggctt     1680

caaccatggt ttcaactgcg cagaggccat caattttgcc actccgcgat ggattgatta     1740

tggcaaaatg gcctcccagt gtagctgtgg ggaggcaagg gtgacctttt ccatggatgc     1800

cttcgtgcgc atcctgcaac ctgaacgcta tgacctgtgg aaacgtgggc aagaccgggc     1860

agttgtggac cacatggagc ccagggtacc agccagccaa gagctgagca cccagaagga     1920

agtccagtta cccaggagag cagcgctggg cctgagacaa ctcccttccc actgggcccg     1980

gcattcccct tggcctatgg ctgcccgcag tgggacacgg tgccacaccc ttgtgtgctc     2040

ttcactccca cgccgatctg cagttagtgg cactgctacg cagccccggg ctgctgctgt     2100

ccacagctct aagaagccca gctcaactcc atcatccacc cctggtccat ctgcacagat     2160

tatccacccg tcaaatggca gacgtggtcg tggtcgccct cctcagaaac tgagagctca     2220

ggagctgacc ctccagactc cagccaagag gcccctcttg gcgggcacaa catgcacagc     2280

ttcgggccca gaacctgagc ccctacctga ggatggggct ttgatggaca agcctgtacc     2340

actgagccca gggctccagc atcctgtcaa ggcttctggg tgcagctggg cccctgtgcc     2400

ctaagtccac gggctgtctt tatatcccac tgccctgctg tgtgacagtt tgatgaaact     2460

ggttacattt acatcccaaa actttggttg agtttgcagg actctaggca tgcatgaaag     2520

agcccccctg gtgatgccct tggatgctgc caagtccatg gtagttttca attttgccat     2580

acttttgttc ttcctaccgg accctggaat gtctttggat attgctaaaa tctatttctg     2640

cagctgaggt tttatccact ggacacattt gtgtgtgaga actaggtctt gttgaggtta     2700

gcgtaacctg gtatatgcaa ctaccatcct ctgggccaac tgtggaagct gctgcacttg     2760

tgaagaatcc tgagctttga ttcctcttca gtctacgcat ttctctcttc ccctccctca     2820

cccccttttt cttataaaac taggttcttt atacagataa ggtcagtaga gttccagaat     2880

aaaagatatg acttttctga gttatttatg tacttaaaat atgttgtcac agtatttgtt     2940

cccaaatata ttaaaggtaa ccaaaatgtt aaaaaaaaaa aaaaaaaa                  2988


<210> 10
<211> 523
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Thr Met Lys Ser Lys Ala Asn Cys Ala Gln Asn Pro Asn Cys 
1               5                   10                  15      


Asn Ile Met Ile Phe His Pro Thr Lys Glu Glu Phe Asn Asp Phe Asp 
            20                  25                  30          


Lys Tyr Ile Ala Tyr Met Glu Ser Gln Gly Ala His Arg Ala Gly Leu 
        35                  40                  45              


Ala Lys Ile Ile Pro Pro Lys Glu Trp Lys Ala Arg Glu Thr Tyr Asp 
    50                  55                  60                  


Asn Ile Ser Glu Ile Leu Ile Ala Thr Pro Leu Gln Gln Val Ala Ser 
65                  70                  75                  80  


Gly Arg Ala Gly Val Phe Thr Gln Tyr His Lys Lys Lys Lys Ala Met 
                85                  90                  95      


Thr Val Gly Glu Tyr Arg His Leu Ala Asn Ser Lys Lys Tyr Gln Thr 
            100                 105                 110         


Pro Pro His Gln Asn Phe Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn 
        115                 120                 125             


Arg Ile Tyr Asn Ser Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu 
    130                 135                 140                 


Phe Asp Glu Asn Thr Lys Gln Trp Asn Leu Gly His Leu Gly Thr Ile 
145                 150                 155                 160 


Gln Asp Leu Leu Glu Lys Glu Cys Gly Val Val Ile Glu Gly Val Asn 
                165                 170                 175     


Thr Pro Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His 
            180                 185                 190         


Thr Glu Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Leu Gly Glu 
        195                 200                 205             


Pro Lys Thr Trp Tyr Val Val Pro Pro Glu His Gly Gln Arg Leu Glu 
    210                 215                 220                 


Arg Leu Ala Arg Glu Leu Phe Pro Gly Ser Ser Arg Gly Cys Gly Ala 
225                 230                 235                 240 


Phe Leu Arg His Lys Val Ala Leu Ile Ser Pro Thr Val Leu Lys Glu 
                245                 250                 255     


Asn Gly Ile Pro Phe Asn Arg Ile Thr Gln Glu Ala Gly Glu Phe Met 
            260                 265                 270         


Val Thr Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn 
        275                 280                 285             


Cys Ala Glu Ala Ile Asn Phe Ala Thr Pro Arg Trp Ile Asp Tyr Gly 
    290                 295                 300                 


Lys Met Ala Ser Gln Cys Ser Cys Gly Glu Ala Arg Val Thr Phe Ser 
305                 310                 315                 320 


Met Asp Ala Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Asp Leu Trp 
                325                 330                 335     


Lys Arg Gly Gln Asp Arg Ala Val Val Asp His Met Glu Pro Arg Val 
            340                 345                 350         


Pro Ala Ser Gln Glu Leu Ser Thr Gln Lys Glu Val Gln Leu Pro Arg 
        355                 360                 365             


Arg Ala Ala Leu Gly Leu Arg Gln Leu Pro Ser His Trp Ala Arg His 
    370                 375                 380                 


Ser Pro Trp Pro Met Ala Ala Arg Ser Gly Thr Arg Cys His Thr Leu 
385                 390                 395                 400 


Val Cys Ser Ser Leu Pro Arg Arg Ser Ala Val Ser Gly Thr Ala Thr 
                405                 410                 415     


Gln Pro Arg Ala Ala Ala Val His Ser Ser Lys Lys Pro Ser Ser Thr 
            420                 425                 430         


Pro Ser Ser Thr Pro Gly Pro Ser Ala Gln Ile Ile His Pro Ser Asn 
        435                 440                 445             


Gly Arg Arg Gly Arg Gly Arg Pro Pro Gln Lys Leu Arg Ala Gln Glu 
    450                 455                 460                 


Leu Thr Leu Gln Thr Pro Ala Lys Arg Pro Leu Leu Ala Gly Thr Thr 
465                 470                 475                 480 


Cys Thr Ala Ser Gly Pro Glu Pro Glu Pro Leu Pro Glu Asp Gly Ala 
                485                 490                 495     


Leu Met Asp Lys Pro Val Pro Leu Ser Pro Gly Leu Gln His Pro Val 
            500                 505                 510         


Lys Ala Ser Gly Cys Ser Trp Ala Pro Val Pro 
        515                 520             


<210> 11
<211> 2339
<212> DNA
<213> Homo sapiens

<400> 11
ccaagcctga gaatcaggag aagcctcaca gtgacacccc caactgagga aactcacaga       60

gctgggacat actctacttc ttcagaaaaa agtatactga ctagagtgga gtccccctgg      120

ggagtcagaa agcctgtgaa agatctcact tgttcaaaag tccaagtgtg aattactgtc      180

tcacagataa accaaagtat tttgaaaaac aaaggggaga aaagaaatta ctccccagaa      240

ctctcaggca tctagaggac acccaagaac gtgggagtca gctgcttctt gtgtgcagcc      300

atgaagtctg tgcactccag tccccagaac acgagtcata ccatcatgac gttttaccca      360

accatggaag aatttgcaga tttcaacaca tatgttgctt acatggagtc ccaaggcgca      420

catcaagctg gccttgccaa ggtaattcca cccaaggaat ggaaagccag acagatgtat      480

gatgatatcg aagacatctt aatagccact cccctccagc aggtgacctc tgggcaggga      540

ggtgtgttta ctcaatacca taaaaagaag aaagccatga gggtggggca gtatcgccgc      600

ttggcaaaca gtaaaaaata tcagactccg ccacaccaga attttgcaga tttggagcaa      660

cgatactgga agagccaccc cggtaatcca ccaatttatg gtgctgatat cagcggctcc      720

ttatttgaag aaagcactaa acaatggaac ctaggacacc tgggaacaat tctggacctg      780

ttggagcagg aatgtggggt tgtcatcgag ggtgtcaaca caccctacct gtactttggc      840

atgtggaaga ccacgtttgc ctggcacaca gaggacatgg acctttacag catcaactac      900

ctgcactttg gggagcccaa aacttggtac gtggtgcccc cagaacatgg tcagcacctg      960

gaacgcctgg ccagggagct cttcccagac atttctcggg gctgtgaggc cttcctgcgg     1020

cacaaagtgg ccctcatctc gcctacagtt ctcaaggaaa atgggattcc cttcaattgc     1080

atgactcagg aggctgggga gttcatggtg acctttccct atggctacca tgctggcttc     1140

aatcacggct tcaactgcgc agaagccatt aattttgcca ctccacgatg gattgattat     1200

ggcaaaatgg cctctcagtg tagctgtggg gagtcgacag tgaccttttc catggacccc     1260

tttgtgcgca ttgtgcaacc cgagagttat gagctctgga aacacaggca agacttggcc     1320

attgtggaac acacagagcc cagggttgca gaaagccaag agctgagcaa ctggagagat     1380

gatatagtac ttagaagagc tgctctgggc ctgaggcttc tcccaaacct cacagcccag     1440

tgtcccacac agcctgtgtc ctcagggcac tgttacaacc caaaaggctg tggcactgat     1500

gctgtgcctg gatccgcatt ccaaagctct gcatatcata cccagaccca gtcacttacc     1560

ctggggatgt cagccagggt tcttctccct tccactggaa gctggggttc tggtcgtggt     1620

cgtggtcgtg gtcaaggtca aggtcgaggt tgcagtcgtg gtcgtggtca tggttgttgt     1680

actcgagaac tggggactga ggagccaact gttcagcctg catccaagag gcgcctttta     1740

atgggtacaa ggagtagagc tcaaggccac aggcctcagc tcccgcttgc caatgatttg     1800

atgacaaatc tgtccctttg agtggtggcc ttcagcatct tgccaaggct tctggctgct     1860

gctgtgtccc tgatcttcaa ctcctggggc ccccactgga tcgtgatgaa accatgcacc     1920

ctggcctgtg cctgctatcc ctcaacagca ctactagtaa tctccctgat gttgtctgca     1980

tgactcctcc caatgtcatt gtgcctttga ttaagttttc cagggacact ggtggggact     2040

ggaactgatt aagttcacca gggacacttg cctggtgaac atgggcaagg ctgtagcaat     2100

ggaccacttt tacggctcta gggttctgac tccaactaag ttttccagaa tctcctgggc     2160

tcctgactca tctgctgggt ctaaagacac tgagtttagg gatattttcc tccaatacat     2220

gatcaatcct ctggatccac ggctatggaa tatggtgaca aatgtcagtg tctctcttat     2280

tccaacccca ggatcagaga agattcttta cctgcagtaa ctgacacatt tccaaggcc      2339


<210> 12
<211> 506
<212> PRT
<213> Homo sapiens

<400> 12
Met Lys Ser Val His Ser Ser Pro Gln Asn Thr Ser His Thr Ile Met 
1               5                   10                  15      


Thr Phe Tyr Pro Thr Met Glu Glu Phe Ala Asp Phe Asn Thr Tyr Val 
            20                  25                  30          


Ala Tyr Met Glu Ser Gln Gly Ala His Gln Ala Gly Leu Ala Lys Val 
        35                  40                  45              


Ile Pro Pro Lys Glu Trp Lys Ala Arg Gln Met Tyr Asp Asp Ile Glu 
    50                  55                  60                  


Asp Ile Leu Ile Ala Thr Pro Leu Gln Gln Val Thr Ser Gly Gln Gly 
65                  70                  75                  80  


Gly Val Phe Thr Gln Tyr His Lys Lys Lys Lys Ala Met Arg Val Gly 
                85                  90                  95      


Gln Tyr Arg Arg Leu Ala Asn Ser Lys Lys Tyr Gln Thr Pro Pro His 
            100                 105                 110         


Gln Asn Phe Ala Asp Leu Glu Gln Arg Tyr Trp Lys Ser His Pro Gly 
        115                 120                 125             


Asn Pro Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu Phe Glu Glu 
    130                 135                 140                 


Ser Thr Lys Gln Trp Asn Leu Gly His Leu Gly Thr Ile Leu Asp Leu 
145                 150                 155                 160 


Leu Glu Gln Glu Cys Gly Val Val Ile Glu Gly Val Asn Thr Pro Tyr 
                165                 170                 175     


Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu Asp 
            180                 185                 190         


Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Thr 
        195                 200                 205             


Trp Tyr Val Val Pro Pro Glu His Gly Gln His Leu Glu Arg Leu Ala 
    210                 215                 220                 


Arg Glu Leu Phe Pro Asp Ile Ser Arg Gly Cys Glu Ala Phe Leu Arg 
225                 230                 235                 240 


His Lys Val Ala Leu Ile Ser Pro Thr Val Leu Lys Glu Asn Gly Ile 
                245                 250                 255     


Pro Phe Asn Cys Met Thr Gln Glu Ala Gly Glu Phe Met Val Thr Phe 
            260                 265                 270         


Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu 
        275                 280                 285             


Ala Ile Asn Phe Ala Thr Pro Arg Trp Ile Asp Tyr Gly Lys Met Ala 
    290                 295                 300                 


Ser Gln Cys Ser Cys Gly Glu Ser Thr Val Thr Phe Ser Met Asp Pro 
305                 310                 315                 320 


Phe Val Arg Ile Val Gln Pro Glu Ser Tyr Glu Leu Trp Lys His Arg 
                325                 330                 335     


Gln Asp Leu Ala Ile Val Glu His Thr Glu Pro Arg Val Ala Glu Ser 
            340                 345                 350         


Gln Glu Leu Ser Asn Trp Arg Asp Asp Ile Val Leu Arg Arg Ala Ala 
        355                 360                 365             


Leu Gly Leu Arg Leu Leu Pro Asn Leu Thr Ala Gln Cys Pro Thr Gln 
    370                 375                 380                 


Pro Val Ser Ser Gly His Cys Tyr Asn Pro Lys Gly Cys Gly Thr Asp 
385                 390                 395                 400 


Ala Val Pro Gly Ser Ala Phe Gln Ser Ser Ala Tyr His Thr Gln Thr 
                405                 410                 415     


Gln Ser Leu Thr Leu Gly Met Ser Ala Arg Val Leu Leu Pro Ser Thr 
            420                 425                 430         


Gly Ser Trp Gly Ser Gly Arg Gly Arg Gly Arg Gly Gln Gly Gln Gly 
        435                 440                 445             


Arg Gly Cys Ser Arg Gly Arg Gly His Gly Cys Cys Thr Arg Glu Leu 
    450                 455                 460                 


Gly Thr Glu Glu Pro Thr Val Gln Pro Ala Ser Lys Arg Arg Leu Leu 
465                 470                 475                 480 


Met Gly Thr Arg Ser Arg Ala Gln Gly His Arg Pro Gln Leu Pro Leu 
                485                 490                 495     


Ala Asn Asp Leu Met Thr Asn Leu Ser Leu 
            500                 505     


<210> 13
<211> 2405
<212> DNA
<213> Homo sapiens

<400> 13
tccggcgtgg tgcgcaggcg cggtatcccc cctcccccgc cagctcgacc ccggtgtggt       60

gcgcaggcgc agtctgcgca gggactggcg ggactgcgcg gcggcaacag cagacatgtc      120

gggggtccgg ggcctgtcgc ggctgctgag cgctcggcgc ctggcgctgg ccaaggcgtg      180

gccaacagtg ttgcaaacag gaacccgagg ttttcacttc actgttgatg ggaacaagag      240

ggcatctgct aaagtttcag attccatttc tgctcagtat ccagtagtgg atcatgaatt      300

tgatgcagtg gtggtaggcg ctggaggggc aggcttgcga gctgcatttg gcctttctga      360

ggcagggttt aatacagcat gtgttaccaa gctgtttcct accaggtcac acactgttgc      420

agcacaggga ggaatcaatg ctgctctggg gaacatggag gaggacaact ggaggtggca      480

tttctacgac accgtgaagg gctccgactg gctgggggac caggatgcca tccactacat      540

gacggagcag gcccccgccg ccgtggtcga gctagaaaat tatggcatgc cgtttagcag      600

aactgaagat gggaagattt atcagcgtgc atttggtgga cagagcctca agtttggaaa      660

gggcgggcag gcccatcggt gctgctgtgt ggctgatcgg actggccact cgctattgca      720

caccttatat ggaaggtctc tgcgatatga taccagctat tttgtggagt attttgcctt      780

ggatctcctg atggagaatg gggagtgccg tggtgtcatc gcactgtgca tagaggacgg      840

gtccatccat cgcataagag caaagaacac tgttgttgcc acaggaggct acgggcgcac      900

ctacttcagc tgcacgtctg cccacaccag cactggcgac ggcacggcca tgatcaccag      960

ggcaggcctt ccttgccagg acctagagtt tgttcagttc caccctacag gcatatatgg     1020

tgctggttgt ctcattacgg aaggatgtcg tggagaggga ggcattctca ttaacagtca     1080

aggcgaaagg tttatggagc gatacgcccc tgtcgcgaag gacctggcgt ctagagatgt     1140

ggtgtctcgg tccatgactc tggagatccg agaaggaaga ggctgtggcc ctgagaaaga     1200

tcacgtctac ctgcagctgc accacctacc tccagagcag ctggccacgc gcctgcctgg     1260

catttcagag acagccatga tcttcgctgg cgtggacgtc acgaaggagc cgatccctgt     1320

cctccccacc gtgcattata acatgggcgg cattcccacc aactacaagg ggcaggtcct     1380

gaggcacgtg aatggccagg atcagattgt gcccggcctg tacgcctgtg gggaggccgc     1440

ctgtgcctcg gtacatggtg ccaaccgcct cggggcaaac tcgctcttgg acctggttgt     1500

ctttggtcgg gcatgtgccc tgagcatcga agagtcatgc aggcctggag ataaagtccc     1560

tccaattaaa ccaaacgctg gggaagaatc tgtcatgaat cttgacaaat tgagatttgc     1620

tgatggaagc ataagaacat cggaactgcg actcagcatg cagaagtcaa tgcaaaatca     1680

tgctgccgtg ttccgtgtgg gaagcgtgtt gcaagaaggt tgtgggaaaa tcagcaagct     1740

ctatggagac ctaaagcacc tgaagacgtt cgaccgggga atggtctgga acacggacct     1800

ggtggagacc ctggagctgc agaacctgat gctgtgtgcg ctgcagacca tctacggagc     1860

agaggcacgg aaggagtcac ggggcgcgca tgccagggaa gactacaagg tgcggattga     1920

tgagtacgat tactccaagc ccatccaggg gcaacagaag aagccctttg aggagcactg     1980

gaggaagcac accctgtcct atgtggacgt tggcactggg aaggtcactc tggaatatag     2040

acccgtgatc gacaaaactt tgaacgaggc tgactgtgcc accgtcccgc cagccattcg     2100

ctcctactga tgagacaaga tgtggtgatg acagaatcag cttttgtaat tatgtataat     2160

agctcatgca tgtgtccatg tcataactgt cttcatacgc ttctgcactc tggggaagaa     2220

ggagtacatt gaagggagat tggcacctag tggctgggag cttgccagga acccagtggc     2280

cagggagcgt ggcacttacc tttgtccctt gcttcattct tgtgagatga taaaactggg     2340

cacagctctt aaataaaata taaatgaaca aactttcttt tatttccaaa aaaaaaaaaa     2400

aaaaa                                                                 2405


<210> 14
<211> 664
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu 
1               5                   10                  15      


Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly 
            20                  25                  30          


Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala Ser Ala Lys Val Ser 
        35                  40                  45              


Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala 
    50                  55                  60                  


Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu 
65                  70                  75                  80  


Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr 
                85                  90                  95      


Arg Ser His Thr Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly 
            100                 105                 110         


Asn Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys 
        115                 120                 125             


Gly Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Met Thr Glu 
    130                 135                 140                 


Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe 
145                 150                 155                 160 


Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln 
                165                 170                 175     


Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val 
            180                 185                 190         


Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser 
        195                 200                 205             


Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu 
    210                 215                 220                 


Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu 
225                 230                 235                 240 


Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr 
                245                 250                 255     


Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser 
            260                 265                 270         


Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln 
        275                 280                 285             


Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly 
    290                 295                 300                 


Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn 
305                 310                 315                 320 


Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp 
                325                 330                 335     


Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg 
            340                 345                 350         


Glu Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu 
        355                 360                 365             


His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser 
    370                 375                 380                 


Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile 
385                 390                 395                 400 


Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn 
                405                 410                 415     


Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val 
            420                 425                 430         


Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly 
        435                 440                 445             


Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly 
    450                 455                 460                 


Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys 
465                 470                 475                 480 


Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu 
                485                 490                 495     


Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg 
            500                 505                 510         


Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val 
        515                 520                 525             


Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly 
    530                 535                 540                 


Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr 
545                 550                 555                 560 


Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu 
                565                 570                 575     


Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Ala His 
            580                 585                 590         


Ala Arg Glu Asp Tyr Lys Val Arg Ile Asp Glu Tyr Asp Tyr Ser Lys 
        595                 600                 605             


Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys 
    610                 615                 620                 


His Thr Leu Ser Tyr Val Asp Val Gly Thr Gly Lys Val Thr Leu Glu 
625                 630                 635                 640 


Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr 
                645                 650                 655     


Val Pro Pro Ala Ile Arg Ser Tyr 
            660                 


<210> 15
<211> 1161
<212> DNA
<213> Homo sapiens

<400> 15
acccgggaaa ccggaagccg cctcccactt ggttgctcgt acgcggctag tgggtcctca       60

gtggatgtag gctgggcgcc gcgatgttcg acgggacacc ggcggagagc gacctcgggg      120

ttaaggggtg gggctgacgt caggagccaa gatggcggcg gtggtcgccc tctccttgag      180

gcgccggttg ccggccacaa cccttggcgg agcctgcctg caggcctccc gaggagccca      240

gacagctgca gccacagctc cccgtatcaa gaaatttgcc atctatcgat gggacccaga      300

caaggctgga gacaaacctc atatgcagac ttatgaagtt gaccttaata aatgtggccc      360

catggtattg gatgctttaa tcaagattaa gaatgaagtt gactctactt tgaccttccg      420

aagatcatgc agagaaggca tctgtggctc ttgtgcaatg aacatcaatg gaggcaacac      480

tctagcttgc acccgaagga ttgacaccaa cctcaataag gtctcaaaaa tctaccctct      540

tccacacatg tatgtgataa aggatcttgt tcccgatttg agcaacttct atgcacagta      600

caaatccatt gagccttatt tgaagaagaa ggatgaatct caggaaggca agcagcagta      660

tctgcagtcc atagaagagc gtgagaaact ggacgggctc tacgagtgca ttctctgtgc      720

ctgctgtagc accagctgcc ccagctactg gtggaacgga gacaaatatc tggggcctgc      780

agttcttatg caggcctatc gctggatgat tgactccaga gatgacttca cagaggagcg      840

cctggccaag ctgcaggacc cattctctct ataccgctgc cacaccatca tgaactgcac      900

aaggacctgt cctaagggtc tgaatccagg gaaagctatt gcagagatca agaaaatgat      960

ggcaacctat aaggagaaga aagcttcagt ttaactgttt ccatgctaaa catgatttat     1020

aaccagctca gagctgaaca taatttatat ctaatttgag ttcctttaaa gatcttggtt     1080

ttccatgaat acagcatgta taataaaaat tttaagaaat aaatgttatt ctactttatt     1140

aacaaaaaaa aaaaaaaaaa a                                               1161


<210> 16
<211> 280
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Ala Val Val Ala Leu Ser Leu Arg Arg Arg Leu Pro Ala Thr 
1               5                   10                  15      


Thr Leu Gly Gly Ala Cys Leu Gln Ala Ser Arg Gly Ala Gln Thr Ala 
            20                  25                  30          


Ala Ala Thr Ala Pro Arg Ile Lys Lys Phe Ala Ile Tyr Arg Trp Asp 
        35                  40                  45              


Pro Asp Lys Ala Gly Asp Lys Pro His Met Gln Thr Tyr Glu Val Asp 
    50                  55                  60                  


Leu Asn Lys Cys Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys 
65                  70                  75                  80  


Asn Glu Val Asp Ser Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly 
                85                  90                  95      


Ile Cys Gly Ser Cys Ala Met Asn Ile Asn Gly Gly Asn Thr Leu Ala 
            100                 105                 110         


Cys Thr Arg Arg Ile Asp Thr Asn Leu Asn Lys Val Ser Lys Ile Tyr 
        115                 120                 125             


Pro Leu Pro His Met Tyr Val Ile Lys Asp Leu Val Pro Asp Leu Ser 
    130                 135                 140                 


Asn Phe Tyr Ala Gln Tyr Lys Ser Ile Glu Pro Tyr Leu Lys Lys Lys 
145                 150                 155                 160 


Asp Glu Ser Gln Glu Gly Lys Gln Gln Tyr Leu Gln Ser Ile Glu Glu 
                165                 170                 175     


Arg Glu Lys Leu Asp Gly Leu Tyr Glu Cys Ile Leu Cys Ala Cys Cys 
            180                 185                 190         


Ser Thr Ser Cys Pro Ser Tyr Trp Trp Asn Gly Asp Lys Tyr Leu Gly 
        195                 200                 205             


Pro Ala Val Leu Met Gln Ala Tyr Arg Trp Met Ile Asp Ser Arg Asp 
    210                 215                 220                 


Asp Phe Thr Glu Glu Arg Leu Ala Lys Leu Gln Asp Pro Phe Ser Leu 
225                 230                 235                 240 


Tyr Arg Cys His Thr Ile Met Asn Cys Thr Arg Thr Cys Pro Lys Gly 
                245                 250                 255     


Leu Asn Pro Gly Lys Ala Ile Ala Glu Ile Lys Lys Met Met Ala Thr 
            260                 265                 270         


Tyr Lys Glu Lys Lys Ala Ser Val 
        275                 280 


<210> 17
<211> 2858
<212> DNA
<213> Homo sapiens

<400> 17
gcgtcacttc cgtccagacc ggaacccaag atggctgcgc tgttgctgag acacgttggt       60

cgtcattgcc tccgagccca ctttagccct cagctctgta tcagaaatgc tgttcctttg      120

ggaaccacgg ccaaagaaga gatggagcgg ttctggaata agaatatagg ttcaaaccgt      180

cctctgtctc cccacattac tatctacagt tggtctcttc ccatggcgat gtccatctgc      240

caccgtggca ctggtattgc tttgagtgca ggggtctctc tttttggcat gtcggccctg      300

ttactccctg ggaactttga gtcttatttg gaacttgtga agtccctgtg tctggggcca      360

gcactgatcc acacagctaa gtttgcactt gtcttccctc tcatgtatca tacctggaat      420

gggatccgac acttgatgtg ggacctagga aaaggcctga agattcccca gctataccag      480

tctggagtgg ttgtcctggt tcttactgtg ttgtcctcta tggggctggc agccatgtga      540

agaaaggagg ctcccagcat catcttccta cacattatta cattcaccca tctttctgtt      600

tgtcattctt atctccagcc tgggaaaagt tctccttatt tgtttagatc cttttgtatt      660

ttcagatctc cttggagcag tagagtacct ggtagaccat aatagtggaa aagggtctag      720

ttttcccctt gtttctaaag atgaggtggc tgcaaaaact cccctttttt gcccacagct      780

tgcctactct cggcctagaa gcagttattc tctctccata ttgggctttg atttgtgctg      840

agggtcagct tttggctcct tcttcctgag acagtggaaa caatgccagc tctgtggctt      900

ctgccctggg gatgggccgg gttggggggt gggttggtga ggctttgggt gccactgcct      960

gtgggttgct ggcttaaagg acaattctct tcattggtga gagcccaggc cattaacacc     1020

tacacagtgt tattgaaaga agagaggtgg gggtggaggg gaattagtct gtcccagcta     1080

gagggagata aagagggcta gttagttctt ggagcagctg cttttgagga gaaaatatat     1140

agctttggac acgaggaaga tctagaaaat tatcattgaa catattaatg gttatttctt     1200

tttcttggat ttccagaaaa gcctcttaat tttatgcttt ctcatcgaag taatgtaccc     1260

tttttttctg aaactgaatt aaatactcat tttatctttg actctccttg aaatctagag     1320

aaaccaagaa aatggctgtt gggaaggaac caatttcctc ctcttccctc gggtctcagg     1380

catttacatc ctccctctcc ccgcaatctg acctttacca ggagggaaac agttctccta     1440

catctcatca ttggaaaagt tttcagggaa tcagatagaa cttagccaga gatttaaata     1500

tcacagaaaa gcctcagaga aggaaggaga aaaagaaaag aagtgacgca tgtagagtgc     1560

ttttgggtta taggcaccaa aatcccatta aggactgatt ataagcttca tggtacagtt     1620

cagcaaatta tgattcattg aggggcacag aggaccagtg ttggtgacag ctaggggatg     1680

atgacctgag gttataggct tggggtgaat gaagcataga gttttttttt aaaaaagaag     1740

ggattgttga aaacctggca aaaatgtata atttaatgag aaaacttgct gcttttaaaa     1800

tccatatagg ccaggcttta gcaggcatgc tgttttgata gtttttggga actctggaat     1860

aagagactta tctcatctgt cacttcgagt tgttggccag ccagttaaag ctgtgggtcg     1920

aagaggggaa atgttaactg gctggtgtca attggatagg aagaccttag ttaaggtggg     1980

gacccgctgt tttaacagtc ttcattcagg gtcccaaata gtatttggct ttaagtaatg     2040

attggttttc cctttttact agaggggccc tgggaagtcc ttgtaccttt cctccatttt     2100

aaaccagctg ttctctactt tgtccttgga atgagggaca agtgatcatg acagaacact     2160

ttgtcattgg gactgggaaa ggtttggcaa gggcattaaa tttaacagcc agtgccagga     2220

aaatataaaa tggggtcaat gataaacagc tgttagaggc tggaaaatgg gtagggcagt     2280

tgaatttttt ggtggtttcg taccatttgg gtgattgaag catggtagtg ggtgggtggg     2340

gggtgtgaca gagcatcatg tttgttattc tgccttaaat ttctacttac tgtctttttc     2400

ttctctgtct tccaatcact ttaatatctt caattttcaa actatatttg tacttgggct     2460

tagatagaaa gtcttacaca agcatagtat cttctacttt ggttttccct accttttctt     2520

ccccaccttc tccaaacaca catatacata ctctactcaa ttctatttct gattttgtag     2580

ttgttagttg tccatgctca ggataaaaaa tgagtgggta gggttgaggg actggttctt     2640

tgaggttctg ccctttttcc atgattcaga ccaactttct cttggtcatt tctggagtat     2700

aactgactca attcttgtaa aaatgtgttc cacccaaacc actgtatgtt cttttcccta     2760

ctttattttc tcctaccttc cttctcctaa ttgtgttaca agaggcagcc atagcaagaa     2820

tggaaaatcc agatcagtaa aagattcaac aaaaaaaa                             2858


<210> 18
<211> 169
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Ala Leu Leu Leu Arg His Val Gly Arg His Cys Leu Arg Ala 
1               5                   10                  15      


His Phe Ser Pro Gln Leu Cys Ile Arg Asn Ala Val Pro Leu Gly Thr 
            20                  25                  30          


Thr Ala Lys Glu Glu Met Glu Arg Phe Trp Asn Lys Asn Ile Gly Ser 
        35                  40                  45              


Asn Arg Pro Leu Ser Pro His Ile Thr Ile Tyr Ser Trp Ser Leu Pro 
    50                  55                  60                  


Met Ala Met Ser Ile Cys His Arg Gly Thr Gly Ile Ala Leu Ser Ala 
65                  70                  75                  80  


Gly Val Ser Leu Phe Gly Met Ser Ala Leu Leu Leu Pro Gly Asn Phe 
                85                  90                  95      


Glu Ser Tyr Leu Glu Leu Val Lys Ser Leu Cys Leu Gly Pro Ala Leu 
            100                 105                 110         


Ile His Thr Ala Lys Phe Ala Leu Val Phe Pro Leu Met Tyr His Thr 
        115                 120                 125             


Trp Asn Gly Ile Arg His Leu Met Trp Asp Leu Gly Lys Gly Leu Lys 
    130                 135                 140                 


Ile Pro Gln Leu Tyr Gln Ser Gly Val Val Val Leu Val Leu Thr Val 
145                 150                 155                 160 


Leu Ser Ser Met Gly Leu Ala Ala Met 
                165                 


<210> 19
<211> 1395
<212> DNA
<213> Homo sapiens

<400> 19
cctgttttct ttcgtcgtcg tgggtgggaa ttgtcgccta agtggttccg ggttggtgga       60

tgaccttgag ccctcaggaa cgagatggcg gttctctgga ggctgagtgc cgtttgcggt      120

gccctaggag gccgagctct gttgcttcga actccagtgg tcagacctgc tcatatctca      180

gcatttcttc aggaccgacc tatcccagaa tggtgtggag tgcagcacat acacttgtca      240

ccgagccacc attctggctc caaggctgca tctctccact ggactagcga gagggttgtc      300

agtgttttgc tcctgggtct gcttccggct gcttatttga atccttgctc tgcgatggac      360

tattccctgg ctgcagccct cactcttcat ggtcactggg gccttggaca agttgttact      420

gactatgttc atggggatgc cttgcagaaa gctgccaagg cagggctttt ggcactttca      480

gctttaacct ttgctgggct ttgctatttc aactatcacg atgtgggcat ctgcaaagct      540

gttgccatgc tgtggaagct ctgacctttt tgacttcata ctttgaagaa ttgatgtatg      600

cctctttgcc tctgctttgt catgccatta agctcacaat aaggaagaaa taacagataa      660

gtccattggt ggacagcctt cttctcttaa tcacaagatt attttcagaa tttaatcttt      720

gaggaaaagg tttgagagga attatatcta agttgtgaga ctgagttcta tattctggtg      780

agttaatggg gttgcctccc agcttcttat aagactcaca gtataactaa acatgatata      840

tcagcttttg cctttcaatt tatcaatctc ttaaagagaa tccaacttta ttacgattag      900

tatatgatca aacttccata tttgccttgg gaataatgga caaagggaaa tactcttaat      960

tcatgaataa aaactttgca gaaaattaga cagtgtttaa ttttcgaaaa cttccctctc     1020

tagacagtag ataccaccta ctgatggtta catatactag ggaaatttta aaattaggaa     1080

atgctgatag ctcatattat aaatttctaa atcctaggaa gaaacgcttg gagtgcttct     1140

gaatatacag aagttccatt taagggcaag tttccctgta gatgtatcaa aatactacca     1200

actgtaaatt gagatttaat tcccaaatgt attctacttg ttctaaaaca atctgtccac     1260

aaatataaaa ctataagtaa taaattgtta ttttcgcaca atgggaatct ctaatgtgaa     1320

aatgtattct atgaaaataa tttttttaaa taaaatgtta tataataaaa gtgtcttcta     1380

tgcttttata tatta                                                      1395


<210> 20
<211> 159
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Val Leu Trp Arg Leu Ser Ala Val Cys Gly Ala Leu Gly Gly 
1               5                   10                  15      


Arg Ala Leu Leu Leu Arg Thr Pro Val Val Arg Pro Ala His Ile Ser 
            20                  25                  30          


Ala Phe Leu Gln Asp Arg Pro Ile Pro Glu Trp Cys Gly Val Gln His 
        35                  40                  45              


Ile His Leu Ser Pro Ser His His Ser Gly Ser Lys Ala Ala Ser Leu 
    50                  55                  60                  


His Trp Thr Ser Glu Arg Val Val Ser Val Leu Leu Leu Gly Leu Leu 
65                  70                  75                  80  


Pro Ala Ala Tyr Leu Asn Pro Cys Ser Ala Met Asp Tyr Ser Leu Ala 
                85                  90                  95      


Ala Ala Leu Thr Leu His Gly His Trp Gly Leu Gly Gln Val Val Thr 
            100                 105                 110         


Asp Tyr Val His Gly Asp Ala Leu Gln Lys Ala Ala Lys Ala Gly Leu 
        115                 120                 125             


Leu Ala Leu Ser Ala Leu Thr Phe Ala Gly Leu Cys Tyr Phe Asn Tyr 
    130                 135                 140                 


His Asp Val Gly Ile Cys Lys Ala Val Ala Met Leu Trp Lys Leu 
145                 150                 155                 


<210> 21
<211> 73
<212> DNA
<213> Homo sapiens

<400> 21
ggccggctgg ggttcctggg gatgggattt gcttcctgtc acaaatcaca ttgccaggga       60

tttccaaccg acc                                                          73


<210> 22
<211> 97
<212> DNA
<213> Homo sapiens

<400> 22
ctcaggtgct ctggctgctt gggttcctgg catgctgatt tgtgacttaa gattaaaatc       60

acattgccag ggattaccac gcaaccacga ccttggc                                97


<210> 23
<211> 90
<212> DNA
<213> Homo sapiens

<400> 23
ccgggcccct gtgagcatct taccggacag tgctggattt cccagcttga ctctaacact       60

gtctggtaac gatgttcaaa ggtgacccgc                                        90


<210> 24
<211> 95
<212> DNA
<213> Homo sapiens

<400> 24
ccagctcggg cagccgtggc catcttactg ggcagcattg gatggagtca ggtctctaat       60

actgcctggt aatgatgacg gcggagccct gcacg                                  95


<210> 25
<211> 68
<212> DNA
<213> Homo sapiens

<400> 25
ccctcgtctt acccagcagt gtttgggtgc ggttgggagt ctctaatact gccgggtaat       60

gatggagg                                                                68


<210> 26
<211> 102
<212> DNA
<213> Homo sapiens

<400> 26
ggtcctctga ctctcttcgg tgacgggtat tcttgggtgg ataatacgga ttacgttgtt       60

attgcttaag aatacgcgta gtcgaggaga gtaccagcgg ca                         102


<210> 27
<211> 14
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Glu or Ala

<400> 27
Glu Asp Glu Glu Glu Glu Gln Xaa Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 28
<211> 14
<212> PRT
<213> Pan sp.

<400> 28
Glu Asp Glu Glu Glu Glu Glu Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 29
<211> 14
<212> PRT
<213> Pongo sp.

<400> 29
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 30
<211> 14
<212> PRT
<213> Macaca sp.

<400> 30
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 31
<211> 14
<212> PRT
<213> Papio  sp.

<400> 31
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 32
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Marmoset peptide

<400> 32
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 33
<211> 14
<212> PRT
<213> Tarsius sp.

<400> 33
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 34
<211> 14
<212> PRT
<213> Microcebus sp.

<400> 34
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 35
<211> 14
<212> PRT
<213> Galago sp.

<400> 35
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ser Ala Leu Asp Leu 
1               5                   10                  


<210> 36
<211> 14
<212> PRT
<213> Tupaia sp.

<400> 36
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 37
<211> 14
<212> PRT
<213> Mus sp.

<400> 37
Glu Asp Glu Glu Asp Glu Pro Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 38
<211> 14
<212> PRT
<213> Rattus sp.

<400> 38
Glu Asp Glu Asp Glu Glu Pro Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 39
<211> 14
<212> PRT
<213> Dipodomys sp.

<400> 39
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 40
<211> 14
<212> PRT
<213> Cavia sp.

<400> 40
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 41
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Squirrel peptide

<400> 41
Glu Glu Asp Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 42
<211> 14
<212> PRT
<213> Oryctolagus cuniculus

<400> 42
Glu Asp Glu Asp Glu Asp Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 43
<211> 14
<212> PRT
<213> Ochotona sp.

<400> 43
Glu Asp Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 44
<211> 14
<212> PRT
<213> Vicugna pacos

<400> 44
Glu Glu Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 45
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Dolphin peptide

<400> 45
Glu Glu Glu Glu Glu Asp Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 46
<211> 14
<212> PRT
<213> Bos sp.

<400> 46
Asp Asp Glu Glu Glu Glu His Glu Ala Ala Val Leu Asp Leu 
1               5                   10                  


<210> 47
<211> 14
<212> PRT
<213> Equus caballus

<400> 47
Glu Glu Asp Glu Glu Glu Pro Glu Ala Ala Val Leu Asp Leu 
1               5                   10                  


<210> 48
<211> 14
<212> PRT
<213> Felis catus

<400> 48
Glu Glu Glu Glu Glu Glu Gln Glu Ala Ala Ala Trp Asp Leu 
1               5                   10                  


<210> 49
<211> 14
<212> PRT
<213> Canis lupus

<400> 49
Glu Glu Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 50
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Micro-bat peptide

<400> 50
Glu Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 51
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Mega-bat peptide

<400> 51
Glu Glu Glu Glu Glu Glu Gln Glu Ala Ala Val Leu Asp Leu 
1               5                   10                  


<210> 52
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Hedgehog peptide

<400> 52
Glu Glu Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 53
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Elephant peptide

<400> 53
Glu Glu Asp Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 54
<211> 14
<212> PRT
<213> Procavia capensis

<400> 54
Glu Glu Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 55
<211> 13
<212> PRT
<213> Tenrec ecaudatus

<400> 55
Glu Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10              


<210> 56
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Armadillo peptide

<400> 56
Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  


<210> 57
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Sloth peptide

<400> 57
Glu Glu Asp Asp Glu Glu Gln Glu Ser Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 58
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Opossum peptide

<400> 58
Glu Asp Glu Glu Glu Ala Ala Ala Leu Asp Leu 
1               5                   10      


<210> 59
<211> 14
<212> PRT
<213> Ornithorhynchus anatinus

<400> 59
Glu Glu Glu Glu Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10                  


<210> 60
<211> 13
<212> PRT
<213> Gallus gallus

<400> 60
Glu Glu Glu Glu Glu Gln Glu Ala Ala Val Leu Asp Leu 
1               5                   10              


<210> 61
<211> 10
<212> PRT
<213> Taeniopygia guttata

<400> 61
Glu Glu Gln Glu Ala Ala Ala Leu Asp Leu 
1               5                   10  


<210> 62
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Lizard peptide

<400> 62
Glu Glu Glu Glu Pro Glu Ala Ala Val Leu Asp Leu 
1               5                   10          


<210> 63
<211> 12
<212> PRT
<213> Tetraodon sp.

<400> 63
Leu Lys Lys Gly Gln Gly Ala Ala Ala Arg Arg Leu 
1               5                   10          


