                         SEQUENCE LISTING

<110>  Commonwealth Scientific and Industrial Research 
       Organisation
 
<120>  Transaminase biocatalysts

<130>  515103

<150>  AU 2013902128
<151>  2013-06-12

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  468
<212>  PRT
<213>  Pseudomonas sp.

<400>  1

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Asn Gln Gln Val Asn Val Ala Pro Ser Ala Ala 
            20                  25                  30          


Ala Asp Leu Asn Leu Lys Ala His Trp Met Pro Phe Ser Ala Asn Arg 
        35                  40                  45              


Asn Phe His Lys Asp Pro Arg Ile Ile Val Ala Ala Glu Gly Ser Trp 
    50                  55                  60                  


Leu Val Asp Asp Lys Gly Arg Arg Ile Tyr Asp Ser Leu Ser Gly Leu 
65                  70                  75                  80  


Trp Thr Cys Gly Ala Gly His Ser Arg Lys Glu Ile Ala Asp Ala Val 
                85                  90                  95      


Ala Lys Gln Ile Gly Thr Leu Asp Tyr Ser Pro Gly Phe Gln Tyr Gly 
            100                 105                 110         


His Pro Leu Ser Phe Gln Leu Ala Glu Lys Ile Ala Gln Met Thr Pro 
        115                 120                 125             


Gly Thr Leu Asp His Val Phe Phe Thr Gly Ser Gly Ser Glu Cys Ala 
    130                 135                 140                 


Asp Thr Ser Ile Lys Met Ala Arg Ala Tyr Trp Arg Ile Lys Gly Gln 
145                 150                 155                 160 


Ala Gln Lys Thr Lys Leu Ile Gly Arg Ala Arg Gly Tyr His Gly Val 
                165                 170                 175     


Asn Val Ala Gly Thr Ser Leu Gly Gly Ile Gly Gly Asn Arg Lys Met 
            180                 185                 190         


Phe Gly Pro Leu Met Asp Val Asp His Leu Pro His Thr Leu Gln Pro 
        195                 200                 205             


Gly Met Ala Phe Thr Lys Gly Ala Ala Glu Thr Gly Gly Val Glu Leu 
    210                 215                 220                 


Ala Asn Glu Leu Leu Lys Leu Ile Glu Leu His Asp Ala Ser Asn Ile 
225                 230                 235                 240 


Ala Ala Val Ile Val Glu Pro Met Ser Gly Ser Ala Gly Val Ile Val 
                245                 250                 255     


Pro Pro Lys Gly Tyr Leu Gln Arg Leu Arg Glu Ile Cys Asp Ala Asn 
            260                 265                 270         


Asp Ile Leu Leu Ile Phe Asp Glu Val Ile Thr Ala Phe Gly Arg Met 
        275                 280                 285             


Gly Lys Ala Thr Gly Ala Glu Tyr Phe Gly Val Thr Pro Asp Ile Met 
    290                 295                 300                 


Asn Val Ala Lys Gln Val Thr Asn Gly Ala Val Pro Met Gly Ala Val 
305                 310                 315                 320 


Ile Ala Ser Ser Glu Ile Tyr Asp Thr Phe Met Asn Gln Asn Leu Pro 
                325                 330                 335     


Glu Tyr Ala Val Glu Phe Gly His Gly Tyr Thr Tyr Ser Ala His Pro 
            340                 345                 350         


Val Ala Cys Ala Ala Gly Ile Ala Ala Leu Asp Leu Leu Gln Lys Glu 
        355                 360                 365             


Asn Leu Ile Gln Gln Ser Ala Glu Leu Ala Pro His Phe Glu Lys Ala 
    370                 375                 380                 


Leu His Gly Leu Lys Gly Thr Lys Asn Val Ile Asp Ile Arg Asn Cys 
385                 390                 395                 400 


Gly Leu Ala Gly Ala Ile Gln Ile Ala Ala Arg Asp Gly Asp Ala Ile 
                405                 410                 415     


Val Arg Pro Phe Glu Ala Ser Met Lys Leu Trp Lys Glu Gly Phe Tyr 
            420                 425                 430         


Val Arg Phe Gly Gly Asp Thr Leu Gln Phe Gly Pro Thr Phe Asn Ala 
        435                 440                 445             


Lys Pro Glu Asp Leu Asp Arg Leu Phe Asp Ala Val Gly Glu Ala Leu 
    450                 455                 460                 


Asn Gly Val Ala 
465             


<210>  2
<211>  479
<212>  PRT
<213>  Pseudomonas sp.

<400>  2

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Thr Asp Tyr Ala Lys Leu Phe Glu Gln Asp Arg 
            20                  25                  30          


Ala His Phe Met His Pro Ser Thr His Ala His Asp His Ala Ser Gly 
        35                  40                  45              


Ala Leu Pro Gly Arg Ile Ile Thr Gly Ala Ser Gly Val Arg Ile Arg 
    50                  55                  60                  


Asp His Gln Gly Arg Glu Leu Leu Asp Ala Phe Ala Gly Leu Tyr Cys 
65                  70                  75                  80  


Val Asn Ile Gly Tyr Gly Arg Leu Glu Val Ala Asp Ala Ile His Glu 
                85                  90                  95      


Gln Ala Lys Gln Leu Ala Tyr Tyr His Thr Tyr Val Gly His Ala Ser 
            100                 105                 110         


Glu Ala Ile Ile Glu Leu Ser Ala Arg Ile Ile Arg Asp Trp Ala Pro 
        115                 120                 125             


Ala Gly Met Lys Lys Val Tyr Tyr Gly Leu Ser Gly Ser Asp Ala Asn 
    130                 135                 140                 


Glu Thr Gln Val Lys Leu Val Arg Tyr Tyr Asn Asn Val Leu Gly Arg 
145                 150                 155                 160 


Pro Gln Lys Lys Lys Ile Ile Ser Arg Gln Arg Gly Tyr His Gly Ser 
                165                 170                 175     


Gly Ile Val Thr Gly Ser Leu Thr Gly Leu Ala Ser Phe His Gln His 
            180                 185                 190         


Phe Asp Leu Pro Val Glu Gly Val Lys His Thr Leu Cys Pro His Phe 
        195                 200                 205             


Tyr Lys Ala Pro Ala Gly Met Asp Glu Ala Ala Phe Val Arg His Cys 
    210                 215                 220                 


Ala Gln Glu Leu Glu Asn Leu Ile Leu Ala Glu Gly Pro Asp Thr Val 
225                 230                 235                 240 


Ala Ala Phe Ile Gly Glu Pro Val Met Gly Thr Gly Gly Ile Ile Val 
                245                 250                 255     


Pro Pro Lys Gly Tyr Trp Glu Ala Ile Gln Ala Val Leu Ala Lys Tyr 
            260                 265                 270         


Asp Val Leu Leu Ile Ala Asp Glu Val Val Cys Ala Phe Gly Arg Leu 
        275                 280                 285             


Gly Asp Lys Met Gly Ser Gln Arg His Ala Met Arg Pro Asp Leu Ile 
    290                 295                 300                 


Thr Thr Ala Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Ala Val 
305                 310                 315                 320 


Ile Val Gly Glu Lys Val Trp Asp Val Ile Asp Ser Ala Ser Thr Arg 
                325                 330                 335     


Glu Gly Ala Met Gly His Gly Trp Thr Tyr Ser Gly His Pro Ile Cys 
            340                 345                 350         


Ala Ala Ala Ala Leu Ala Asn Leu Asp Ile Leu Glu Arg Glu Asn Ile 
        355                 360                 365             


Thr Ala Asn Ala Ala Asp Val Gly Gly Tyr Leu Asn Gln Gln Leu Arg 
    370                 375                 380                 


Gln Ala Phe Glu Gly His Pro Leu Val Gly Glu Val Arg Gly Asp Gly 
385                 390                 395                 400 


Met Leu Ala Ala Leu Glu Phe Met Ala Asp Arg Glu Ala Arg Thr Pro 
                405                 410                 415     


Phe Asp Ala Ala Leu Lys Val Gly Pro Lys Val Ser Ala Ala Cys Leu 
            420                 425                 430         


Glu Arg Gly Met Ile Ala Arg Ala Met Pro His Gly Asp Ile Leu Gly 
        435                 440                 445             


Phe Ala Pro Pro Leu Val Leu Ser Arg Ala Glu Ala Asp Glu Val Val 
    450                 455                 460                 


Gly Ile Ala Lys Ala Ala Val Asp Ala Val Ala Ala Glu Val Leu 
465                 470                 475                 


<210>  3
<211>  1347
<212>  DNA
<213>  Pseudomonas sp.

<400>  3
atgaaccagc aagtgaacgt agcgccgtcg gccgccgccg acctgaacct gaaggcccac       60

tggatgccct tcagcgccaa ccgcaacttc cacaaggacc cgcgcatcat cgtggccgcc      120

gagggcagct ggctggtgga cgacaagggc cggcgcatct acgacagcct gtccggcctg      180

tggacctgcg gcgccggtca ctcgcgcaag gaaatcgccg acgcggtggc caagcagatt      240

ggcaccctcg actactcccc gggcttccag tacggccacc cgctgtcctt ccagctggcc      300

gagaagatcg cccagatgac ccccggcacc ctcgaccacg tgttcttcac cggctccggt      360

tccgagtgcg ccgacacctc gatcaagatg gcccgcgcct actggcgcat caaaggccag      420

gcgcagaaga ccaagctgat cggccgcgcc cgtggctacc acggcgtgaa cgtcgccggc      480

acctccctgg gcggcatcgg cggcaaccgc aagatgttcg gcccgctgat ggacgtcgac      540

cacctgccgc acaccctgca gccgggcatg gcctttacca agggtgcggc cgagaccggc      600

ggcgtcgagc tggccaacga actgctgaag ctgatcgagc tgcacgacgc ctccaacatc      660

gccgcggtga tcgtcgagcc gatgtccggc tccgccggcg tgatcgtgcc gccgaagggc      720

tacctgcagc gcctgcggga aatctgcgac gccaacgaca tcctgctgat cttcgacgaa      780

gtcatcaccg ccttcggccg catgggcaag gccaccggcg ccgaatactt cggcgtgacc      840

ccggacatca tgaacgtcgc caagcaggtc accaacggcg ccgtgcccat gggcgcggtg      900

atcgccagca gcgaaatcta cgacaccttc atgaaccaga acctgccgga atacgcggtg      960

gagttcggcc atggctacac ctactccgcg cacccggtcg cctgcgccgc cggcatcgcc     1020

gcgctggacc tgctgcagaa ggaaaacctg atccagcagt ccgccgaact ggcgccgcac     1080

ttcgagaagg ccctgcacgg cctcaagggc acgaagaacg tcatcgacat ccgcaactgc     1140

ggcctggccg gcgccatcca gatcgccgcc cgcgacggcg acgccatcgt ccgcccgttc     1200

gaagccagca tgaagctgtg gaaggaaggc ttctacgtgc gcttcggcgg cgacaccctg     1260

cagttcgggc cgaccttcaa cgccaagccc gaagacctcg accgcctgtt cgacgcggtc     1320

ggcgaagccc tcaacggggt ggcgtaa                                         1347


<210>  4
<211>  1380
<212>  DNA
<213>  Pseudomonas sp.

<400>  4
atgaccgact acgccaagct gttcgagcag gaccgtgcgc acttcatgca cccctccacc       60

cacgcccacg accacgccag cggcgccctg cccgggcgca tcatcaccgg cgcctcgggc      120

gtgcgcatcc gcgaccacca gggccgcgag ctgctggatg ccttcgccgg gctgtactgc      180

gtgaacatcg gctacggccg ccttgaggtg gccgacgcca tccatgagca ggccaagcag      240

ctggcctact accacaccta cgtcggccac gcgtccgagg cgatcatcga gctgtccgcg      300

cggatcatcc gcgactgggc gccggcgggc atgaagaagg tctactacgg cctctccggc      360

tccgacgcca acgaaaccca ggtcaagctg gtgcgctact acaacaacgt gctggggcgg      420

ccgcagaaga agaagatcat ctcgcgccag cgcggctacc acggctcggg catcgtcacc      480

ggcagcctca ccggactggc cagcttccac cagcacttcg acctgccggt ggaaggcgtc      540

aaacacaccc tctgcccgca cttctacaag gccccggcgg gcatggacga ggcggccttc      600

gtgcgccact gcgcccagga gctggagaac ctgatcctcg ccgagggccc ggacaccgtg      660

gcggccttca tcggcgagcc ggtgatgggc accggcggca tcatcgtccc gcccaagggc      720

tactgggagg cgatccaggc ggtgctggcg aagtacgacg tgctgctgat cgccgacgag      780

gtggtctgcg ccttcggccg cctcggcgac aagatgggca gccagcgcca tgccatgcgc      840

ccggacctga tcaccaccgc caagggcctg accagcgcct acgcgccgct gtccgcggtg      900

atcgtcggcg agaaggtctg ggatgtgatc gacagcgcct ccacccgcga aggcgccatg      960

ggccacggct ggacctattc cggccacccg atctgcgcgg cggcggcgct ggccaacctg     1020

gacatcctcg agcgcgagaa catcaccgcc aacgcggcgg acgtcggcgg ctacctcaac     1080

cagcagttgc gccaggcctt cgaaggccac ccgctggtgg gcgaggtgcg cggcgacggc     1140

atgctggcgg cgctggagtt catggccgac cgcgaggcgc gcacgccttt cgacgcggcg     1200

ctgaaggtgg gtccgaaggt ctcggcggcg tgcctggagc gcggcatgat cgcccgcgcc     1260

atgccccacg gcgacatcct cggcttcgcc ccgccgctgg tactcagccg cgccgaggcg     1320

gacgaggtgg tgggcatcgc caaggccgcg gtggacgcgg tggcggcgga ggtgctttga     1380


<210>  5
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized coding sequence

<400>  5
atgaccgact acgccaagct gttcgagcag gaccgtgcgc acttcatgca cccctccacc       60

cacgcccacg accacgccag cggcgccctg cccgggcgca tcatcaccgg cgcctcgggc      120

gtgcgcatcc gcgaccacca gggccgcgag ctgctggatg ccttcgccgg gctgtactgc      180

gtgaacatcg gctacggccg ccttgaggtg gccgacgcca tccatgagca ggccaagcag      240

ctggcctact accacaccta cgtcggccac gcgtccgagg cgatcatcga gctgtccgcg      300

cggatcatcc gcgactgggc gccggcgggc atgaagaagg tctactacgg cctctccggc      360

tccgacgcca acgaaaccca ggtcaagctg gtgcgctact acaacaacgt gctggggcgg      420

ccgcagaaga agaagatcat ctcgcgccag cgcggctacc acggctcggg catcgtcacc      480

ggcagcctca ccggactggc cagcttccac cagcacttcg acctgccggt ggaaggcgtc      540

aaacacaccc tctgcccgca cttctacaag gccccggcgg gcatggacga ggcggccttc      600

gtgcgccact gcgcccagga gctggagaac ctgatcctcg ccgagggccc ggacaccgtg      660

gcggccttca tcggcgagcc ggtgatgggc accggcggca tcatcgtccc gcccaagggc      720

tactgggagg cgatccaggc ggtgctggcg aagtacgacg tgctgctgat cgccgacgag      780

gtggtctgcg ccttcggccg cctcggcgac aagatgggca gccagcgcca tgccatgcgc      840

ccggacctga tcaccaccgc caagggcctg accagcgcct acgcgccgct gtccgcggtg      900

atcgtcggcg agaaggtctg ggatgtgatc gacagcgcct ccacccgcga aggcgccatg      960

ggccacggct ggacctattc cggccacccg atctgcgcgg cggcggcgct ggccaacctg     1020

gacatcctcg agcgcgagaa catcaccgcc aacgcggcgg acgtcggcgg ctacctcaac     1080

cagcagttgc gccaggcctt cgaaggccac ccgctggtgg gcgaggtgcg cggcgacggc     1140

atgctggcgg cgctggagtt catggccgac cgcgaggcgc gcacgccttt cgacgcggcg     1200

ctgaaggtgg gtccgaaggt ctcggcggcg tgcctggagc gcggcatgat cgcccgcgcc     1260

atgccccacg gcgacatcct cggcttcgcc ccgccgctgg tactcagccg cgccgaggcg     1320

gacgaggtgg tgggcatcgc caaggccgcg gtggacgcgg tggcggcgga ggtgctttaa     1380


<210>  6
<211>  454
<212>  PRT
<213>  Pseudomonas sp.

<400>  6

Met Thr Lys Gln Thr Ser Ala Gln Thr Gln His Trp Gln Ala Leu Ser 
1               5                   10                  15      


Arg Glu His His Leu Ala Pro Phe Thr Asp Tyr Lys Gln Leu Asn Glu 
            20                  25                  30          


Lys Gly Ala Arg Ile Ile Thr Lys Ala Glu Gly Val Tyr Leu Trp Asp 
        35                  40                  45              


Ser Glu Gly Asn Lys Ile Leu Asp Gly Met Ala Gly Leu Trp Cys Met 
    50                  55                  60                  


Asn Val Gly Tyr Gly Arg Lys Glu Leu Ala Glu Val Ala Tyr Lys Gln 
65                  70                  75                  80  


Met Leu Glu Leu Pro Tyr Tyr Asn Leu Phe Phe Gln Thr Ala His Pro 
                85                  90                  95      


Pro Ala Leu Glu Leu Ala Lys Ala Ile Ala Asp Ile Ala Pro Glu Gly 
            100                 105                 110         


Met Asn His Val Phe Phe Thr Gly Ser Gly Ser Glu Ser Asn Asp Thr 
        115                 120                 125             


Val Leu Arg Met Val Arg His Tyr Trp Ser Ile Lys Gly Lys Pro Gln 
    130                 135                 140                 


Lys Lys Val Val Ile Gly Arg Trp Asn Gly Tyr His Gly Ser Thr Val 
145                 150                 155                 160 


Ala Gly Val Ser Leu Gly Gly Met Lys Ala Leu His Ser Gln Gly Asp 
                165                 170                 175     


Leu Pro Ile Pro Gly Ile Val His Ile Ala Gln Pro Tyr Trp Tyr Gly 
            180                 185                 190         


Glu Gly Gly Asp Met Ser Ala Glu Glu Phe Gly Val Trp Ala Ala Glu 
        195                 200                 205             


Gln Leu Glu Lys Lys Ile Leu Glu Val Gly Glu Glu Asn Val Ala Ala 
    210                 215                 220                 


Phe Ile Ala Glu Pro Ile Gln Gly Ala Gly Gly Val Ile Val Pro Pro 
225                 230                 235                 240 


Asp Thr Tyr Trp Pro Lys Ile Arg Glu Ile Leu Ala Lys Tyr Glu Ile 
                245                 250                 255     


Leu Phe Ile Ala Asp Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Glu 
            260                 265                 270         


Trp Phe Gly Ser Gln Tyr Tyr Gly Asn Ala Pro Asp Leu Met Pro Ile 
        275                 280                 285             


Ala Lys Gly Leu Thr Ser Gly Tyr Ile Pro Met Gly Gly Val Ile Val 
    290                 295                 300                 


Arg Asp Glu Ile Val Asp Thr Leu Asn Glu Gly Gly Glu Phe Tyr His 
305                 310                 315                 320 


Gly Phe Thr Tyr Ser Gly His Pro Val Ala Ala Ala Val Ala Leu Glu 
                325                 330                 335     


Asn Ile Arg Ile Leu Arg Glu Glu Lys Ile Val Glu Thr Val Lys Ala 
            340                 345                 350         


Glu Thr Ala Pro Tyr Leu Gln Lys Arg Trp Gln Glu Leu Ala Asp His 
        355                 360                 365             


Pro Leu Val Gly Glu Ala Arg Gly Val Gly Met Val Gly Ala Leu Glu 
    370                 375                 380                 


Leu Val Lys Asn Lys Lys Thr Arg Glu Arg Phe Glu Asn Gly Val Gly 
385                 390                 395                 400 


Met Leu Cys Arg Glu His Cys Phe Arg Asn Gly Leu Ile Met Arg Ala 
                405                 410                 415     


Val Gly Asp Thr Met Ile Ile Ser Pro Pro Leu Val Ile Thr Lys Pro 
            420                 425                 430         


Glu Ile Asp Glu Leu Ile Thr Leu Ala Arg Lys Cys Leu Asp Gln Thr 
        435                 440                 445             


Ala Ala Val Ala Leu Ser 
    450                 


<210>  7
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  7

Met Thr Asp Phe Asp Gln Leu Phe Glu Gln Asp Arg Ala His Phe Met 
1               5                   10                  15      


His Pro Ser Thr His Ala His Asp His Ala Ser Gly Ala Leu Pro Gly 
            20                  25                  30          


Arg Ile Ile Thr Gly Ala Ser Gly Ile Arg Ile Arg Asp His Glu Gly 
        35                  40                  45              


Arg Glu Leu Ile Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Val Ala Asp Ala Ile Tyr Lys Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Thr Tyr Val Gly His Ser Thr Glu Ala Ile Ile 
                85                  90                  95      


Glu Leu Ser Ser Arg Ile Ile Arg Asp Trp Ala Pro Ala Gly Met Lys 
            100                 105                 110         


Lys Val Tyr Tyr Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Gln Ile 
        115                 120                 125             


Lys Leu Val Arg Tyr Tyr Asn Asn Val Leu Gly Arg Pro Gln Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Gln Arg Gly Tyr His Gly Ser Gly Ile Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Pro Ser Phe His Gln His Phe Asp Leu Pro 
                165                 170                 175     


Val Glu Gly Ile Lys His Thr Val Cys Pro His Trp Tyr Lys Ala Pro 
            180                 185                 190         


Ala Gly Met Asp Glu Ala Ala Phe Val Arg Tyr Cys Ala Asp Glu Leu 
        195                 200                 205             


Glu Lys Leu Ile Leu Ala Glu Gly Pro Asp Thr Val Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Met Gly Thr Gly Gly Ile Ile Val Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Asn Lys Tyr Asp Val Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Cys Ala Phe Gly Arg Leu Gly Ser Lys Met 
            260                 265                 270         


Gly Ser Gln Arg Tyr Gly Met Arg Pro Asp Leu Ile Thr Thr Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Ala Val Ile Val Gly Glu 
    290                 295                 300                 


Lys Val Trp Asp Val Ile Glu Lys Ala Ser Gln Lys Glu Gly Ala Met 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Gly His Pro Ile Cys Ala Ala Ala Ala 
                325                 330                 335     


Leu Ala Asn Leu Asp Ile Leu Glu Arg Glu Asn Leu Thr Ala Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Ala Tyr Leu Asn Gln Arg Leu Arg Glu Thr Phe Glu 
        355                 360                 365             


Gly His Pro Leu Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala Ala 
    370                 375                 380                 


Leu Glu Phe Met Ala Asp Arg Glu Ala Arg Thr Pro Phe Asp Pro Ala 
385                 390                 395                 400 


Leu Lys Val Gly Pro Lys Val Ser Ala Ala Cys Leu Glu Asp Gly Met 
                405                 410                 415     


Ile Ala Arg Ala Met Pro His Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Val Leu Thr Arg Ala Glu Ala Asp Glu Ile Val Gly Ile Ala Lys 
        435                 440                 445             


Ala Ala Val Asp Glu Val Ala Gly Glu Val Leu 
    450                 455                 


<210>  8
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  8

Met Thr Asp Leu Asp Gln Leu Phe Glu Met Asp Arg Ala His Phe Met 
1               5                   10                  15      


His Pro Ser Thr His Ala His Asp His Ala Ser Gly Ala Leu Pro Gly 
            20                  25                  30          


Arg Ile Ile Thr Gly Gly Lys Gly Ile Arg Ile Gln Asp His Glu Gly 
        35                  40                  45              


Arg Glu Tyr Ile Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Val Ala Asp Ala Ile Tyr Glu Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Thr Tyr Val Gly His Ser Thr Glu Ala Ile Ile 
                85                  90                  95      


Glu Leu Ser Ser Arg Ile Ile Arg Asp Trp Ala Pro Ala Gly Met Lys 
            100                 105                 110         


Lys Val Tyr Tyr Gly Met Ser Gly Ser Asp Ala Asn Glu Thr Gln Ile 
        115                 120                 125             


Lys Leu Val Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Gln Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Gln Arg Gly Tyr His Gly Ser Gly Ile Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Pro Ser Phe His Gln His Phe Asp Leu Pro 
                165                 170                 175     


Ile Glu Arg Ile Lys His Thr Val Cys Pro His Trp Tyr Lys Ala Pro 
            180                 185                 190         


Ala Gly Met Ser Glu Ala Gln Phe Val Arg Tyr Cys Ala Asp Glu Leu 
        195                 200                 205             


Glu Lys Leu Ile Leu Ala Glu Gly Pro Asp Thr Val Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Met Gly Thr Gly Gly Ile Ile Pro Pro Pro Gln Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Asn Lys Tyr Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Cys Gly Phe Gly Arg Leu Gly Ser Lys Met 
            260                 265                 270         


Gly Ser Gln His Tyr Gly Met Lys Pro Asp Leu Ile Thr Val Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Gly Glu 
    290                 295                 300                 


Lys Val Trp Asp Val Ile Glu Lys Gly Ser Gln Glu His Gly Pro Met 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Gly His Pro Ile Cys Ala Ala Ala Ala 
                325                 330                 335     


Leu Ala Asn Leu Asp Ile Leu Glu Arg Glu Asn Leu Thr Gly Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Ala Tyr Leu Gln Gln Arg Leu Arg Glu Thr Phe Gly 
        355                 360                 365             


Gly His Pro Leu Val Gly Glu Val Arg Gly Val Gly Met Leu Ala Ala 
    370                 375                 380                 


Leu Glu Phe Met Ala Asp Lys Asp Ala Arg Thr Pro Phe Asp Pro Ala 
385                 390                 395                 400 


Leu Lys Val Gly Pro Lys Val Ser Ala Ala Cys Leu Glu Asp Gly Met 
                405                 410                 415     


Ile Ala Arg Ala Met Pro His Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Val Ile Thr Arg Ala Glu Val Asp Glu Ile Val Gly Ile Ala Lys 
        435                 440                 445             


Gln Ala Val Asp Glu Val Ala Asp Glu Val Leu 
    450                 455                 


<210>  9
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  9

Met Gln Ser Leu Asp Gln Leu Phe Glu Met Asp Arg Ala His Phe Met 
1               5                   10                  15      


His Pro Ser Thr His Ala His Asp His Ala Ser Gly Ala Leu Pro Gly 
            20                  25                  30          


Arg Ile Ile Thr Gly Gly Lys Gly Ile Arg Ile Glu Asp His Glu Gly 
        35                  40                  45              


Arg Glu Tyr Ile Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Val Ala Asp Ala Ile Tyr Glu Gln Ala Lys Gln 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Thr Tyr Val Gly His Ser Thr Asp Ala Ile Ile 
                85                  90                  95      


Glu Leu Ser Ser Arg Ile Ile Arg Asp Trp Ala Pro Ala Gly Met Lys 
            100                 105                 110         


Lys Val Tyr Tyr Gly Met Ser Gly Ser Asp Ala Asn Glu Thr Gln Ile 
        115                 120                 125             


Lys Leu Val Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Asn Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Glu Arg Gly Tyr His Gly Ser Gly Ile Val Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Pro Ser Phe His Gln His Phe Asp Leu Pro 
                165                 170                 175     


Ile Asp Arg Val Lys His Thr Val Cys Pro His Trp Tyr Arg Ala Pro 
            180                 185                 190         


Ala Gly Met Ser Glu Ala Gln Phe Val Ala Tyr Cys Val Glu Glu Leu 
        195                 200                 205             


Glu Lys Leu Ile Ala Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Ala Glu Pro Val Met Gly Thr Gly Gly Ile Ile Pro Pro Pro Gln Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Arg Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Cys Gly Phe Gly Arg Leu Gly Ser Lys Met 
            260                 265                 270         


Gly Ser Gln His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Val Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Gly Glu 
    290                 295                 300                 


Lys Val Trp Asp Val Ile Glu Lys Gly Ser Gln Glu His Gly Pro Met 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Gly His Pro Ile Cys Ala Ala Ala Ala 
                325                 330                 335     


Leu Ala Asn Leu Asp Ile Leu Glu Arg Glu Asn Leu Thr Gly Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Ala Tyr Leu Gln Gln Arg Leu His Glu Ala Phe Gly 
        355                 360                 365             


Ala His Pro Leu Val Gly Glu Val Arg Gly Val Gly Met Leu Ala Ala 
    370                 375                 380                 


Leu Glu Phe Met Ala Asp Lys Asp Ala Arg Thr Pro Phe Asp Pro Ala 
385                 390                 395                 400 


Leu Lys Val Gly Pro Lys Val Ser Ala Ala Ala Leu Glu Asp Gly Met 
                405                 410                 415     


Ile Ala Arg Ala Met Pro His Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Val Thr Thr Arg Ala Glu Val Asp Glu Ile Val Gly Ile Ala Lys 
        435                 440                 445             


Gln Ala Val Asp Glu Val Ala Asp Glu Val Leu 
    450                 455                 


<210>  10
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  10

Met Thr Ser Leu Asp Gln Leu Phe Glu Glu Asp Arg Ala His Phe Met 
1               5                   10                  15      


His Pro Ser Thr His Ala His Asp His Ala Ser Gly Ala Leu Pro Gly 
            20                  25                  30          


Lys Ile Val Thr Gly Gly Lys Gly Ile Arg Ile Glu Asp His Gln Gly 
        35                  40                  45              


Arg Glu Tyr Ile Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Val Ala Asp Ala Ile Tyr Glu Gln Ala Lys Gln 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Thr Tyr Val Gly His Ser Thr Asp Ala Ile Ile 
                85                  90                  95      


Glu Leu Ser Ser Arg Ile Ile Arg Asp Trp Ala Pro Ala Gly Met Lys 
            100                 105                 110         


Lys Val Tyr Tyr Gly Met Ser Gly Ser Asp Ala Asn Glu Thr Gln Ile 
        115                 120                 125             


Lys Ile Val Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Asn Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Glu Arg Gly Tyr His Gly Ser Gly Ile Val Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Pro Ser Phe His Gln His Phe Asp Leu Pro 
                165                 170                 175     


Ile Asp Arg Val Lys His Thr Val Cys Pro His Trp Tyr Lys Ala Pro 
            180                 185                 190         


Ala Gly Met Ser Glu Ala Gln Phe Val Ala Tyr Cys Val Glu Glu Leu 
        195                 200                 205             


Glu Lys Leu Ile Ala Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Ala Glu Pro Val Met Gly Thr Gly Gly Ile Ile Ala Pro Pro Gln Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Arg Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ser Asp Glu Val Val Cys Gly Phe Gly Arg Leu Gly Ser Lys Met 
            260                 265                 270         


Gly Ala Gln His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Val Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Gly Glu 
    290                 295                 300                 


Lys Val Trp Asp Val Ile Glu Lys Gly Ser Gln Glu His Gly Pro Met 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Gly His Pro Ile Cys Ala Ala Ala Ala 
                325                 330                 335     


Leu Ala Asn Leu Asp Ile Leu Glu Arg Glu Asn Leu Thr Gly Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Ala Tyr Leu Gln Gln Arg Leu His Glu Ala Phe Gly 
        355                 360                 365             


Ala His Pro Leu Val Gly Glu Val Arg Gly Val Gly Met Leu Ala Ala 
    370                 375                 380                 


Leu Glu Phe Met Ala Asp Lys Asp Ala Arg Thr Pro Phe Asp Pro Ala 
385                 390                 395                 400 


Leu Lys Val Gly Pro Lys Val Ser Ala Ala Ala Leu Glu Asp Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met Pro His Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Val Thr Thr Arg Ala Glu Val Asp Glu Ile Val Gly Ile Val Lys 
        435                 440                 445             


Gln Ala Val Asp Glu Val Ala Asp Glu Val Leu 
    450                 455                 


<210>  11
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  11

Met Thr Ser Leu Glu Gln Leu Leu Glu Met Asp Arg Ala His Phe Met 
1               5                   10                  15      


His Pro Ser Thr His Ala Tyr Asp His Ala Ser Gly Ala Leu Pro Gly 
            20                  25                  30          


Arg Ile Ile Thr Gly Gly Lys Gly Ile Arg Ile Glu Asp His Glu Gly 
        35                  40                  45              


Arg Glu Tyr Ile Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Glu Glu Val Ala Asp Ala Ile Tyr Glu Gln Ala Lys Gln 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Thr Tyr Val Gly His Ser Asn Asp Pro Val Ile 
                85                  90                  95      


Glu Leu Ser Ser Arg Ile Ile Glu Asp Trp Ala Pro Ala Gly Met Lys 
            100                 105                 110         


Lys Val Phe Tyr Gly Met Ser Gly Ser Asp Ala Asn Glu Thr Gln Ile 
        115                 120                 125             


Lys Leu Val Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Asn Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ala Arg Glu Arg Ser Tyr His Gly Ser Gly Ile Val Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Pro Ser Phe His Gln His Phe Asp Leu Pro 
                165                 170                 175     


Ile Asp Arg Val Lys His Thr Val Cys Pro His Trp Tyr Asn Ala Pro 
            180                 185                 190         


Pro Gly Met Ser Glu Ala Gln Phe Val Ala Tyr Cys Val Glu Glu Leu 
        195                 200                 205             


Glu Lys Leu Ile Ala Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Ala Glu Pro Val Met Gly Thr Gly Gly Ile Val Pro Pro Pro Gln Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Arg Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Cys Gly Phe Gly Arg Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Ser Glu His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Val Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Ala Val Ile Val Ser Glu 
    290                 295                 300                 


Lys Val Trp Asp Val Ile Glu Lys Gly Ser Arg Glu His Gly Val Met 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Gly His Pro Val Cys Ala Ala Ala Ala 
                325                 330                 335     


Leu Ala Asn Leu Asp Ile Leu Glu Arg Glu Asn Leu Thr Gly Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Ala Tyr Leu Gln Gln Arg Leu His Glu Ala Phe Gly 
        355                 360                 365             


Ala His Pro Leu Val Gly Glu Val Arg Gly Val Gly Met Leu Ala Ala 
    370                 375                 380                 


Leu Glu Phe Met Ala Asp Lys Gly Ala Arg Thr Pro Phe Asp Pro Ala 
385                 390                 395                 400 


Leu Lys Val Ser Gln Lys Val Ala Ala Ala Ala Leu Glu Asp Gly Leu 
                405                 410                 415     


Ile Val Arg Ala Leu Pro His Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Val Thr Thr Arg Ala Glu Val Asp Glu Ile Val Ala Ile Ala Lys 
        435                 440                 445             


Glu Ala Phe Asp Glu Val Ala Asp Ala Val Leu 
    450                 455                 


<210>  12
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  12

Met Thr Asp Thr Asp Asp Leu Leu Glu Met Asp Arg Ala His Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Arg Asp His Ala Ser Gly Glu Leu Pro Gly 
            20                  25                  30          


Arg Ile Ile Thr Gly Gly Lys Gly Ile Arg Ile Gln Asp Ser Glu Gly 
        35                  40                  45              


Arg Glu Tyr Ile Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Ile Ala Asp Ala Ile Tyr Glu Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Thr Tyr Val Gly His Ser Asn Glu Pro Ile Ile 
                85                  90                  95      


Glu Leu Ser Glu Arg Ile Ile Arg Glu Trp Ala Pro Ala Gly Met Ser 
            100                 105                 110         


Lys Val Tyr Tyr Gly Met Ser Gly Ser Asp Ala Asn Glu Thr Gln Ile 
        115                 120                 125             


Lys Leu Val Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Gln Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Gln Arg Gly Tyr His Gly Ser Gly Ile Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Pro Ala Phe His Asn His Phe Asp Leu Pro 
                165                 170                 175     


Leu Glu Pro Ile Arg His Thr Thr Cys Pro His Tyr Tyr Arg Ala Pro 
            180                 185                 190         


Ala Gly Met Ser Glu Ala Glu Phe Ser Arg His Cys Ala Asp Glu Leu 
        195                 200                 205             


Glu Lys Met Ile Leu Ala Glu Gly Pro Asp Thr Val Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Met Gly Thr Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Asn Lys Tyr Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Cys Gly Phe Gly Arg Thr Gly Ser Met Phe 
            260                 265                 270         


Gly Ser His His Tyr Gly Met Lys Pro Asp Leu Ile Thr Val Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Gly Glu 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Ser Asp Gln Tyr Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Gly His Pro Ile Cys Ala Ala Ala Ala 
                325                 330                 335     


Leu Ala Asn Leu Asp Ile Ile Glu Arg Glu Asn Leu Thr Gly Asn Ala 
            340                 345                 350         


Ala Asp Thr Gly Ala Tyr Phe Gln Gln Arg Met Arg Glu Thr Phe Gly 
        355                 360                 365             


Asp His Pro Leu Val Gly Glu Val Arg Gly Val Gly Leu Met Ala Ala 
    370                 375                 380                 


Leu Glu Phe Val Ala Asp Lys Asp Lys Arg Thr Arg Phe Asp Pro Ser 
385                 390                 395                 400 


Leu Lys Val Gly Pro Arg Val Ser Ala Ala Cys Leu Glu Asp Gly Met 
                405                 410                 415     


Ile Ala Arg Ala Met Pro His Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Val Ile Thr Arg Ala Glu Val Asp Glu Ile Val Asp Ile Ala Lys 
        435                 440                 445             


Gln Ala Val Asp Ala Val Ala Asp Glu Leu Val 
    450                 455                 


<210>  13
<211>  426
<212>  PRT
<213>  Escherichia coli

<400>  13

Met Asn Ser Asn Lys Glu Leu Met Gln Arg Arg Ser Gln Ala Ile Pro 
1               5                   10                  15      


Arg Gly Val Gly Gln Ile His Pro Ile Phe Ala Asp Arg Ala Glu Asn 
            20                  25                  30          


Cys Arg Val Trp Asp Val Glu Gly Arg Glu Tyr Leu Asp Phe Ala Gly 
        35                  40                  45              


Gly Ile Ala Val Leu Asn Thr Gly His Leu His Pro Lys Val Val Ala 
    50                  55                  60                  


Ala Val Glu Ala Gln Leu Lys Lys Leu Ser His Thr Cys Phe Gln Val 
65                  70                  75                  80  


Leu Ala Tyr Glu Pro Tyr Leu Glu Leu Cys Glu Ile Met Asn Gln Lys 
                85                  90                  95      


Val Pro Gly Asp Phe Ala Lys Lys Thr Leu Leu Val Thr Thr Gly Ser 
            100                 105                 110         


Glu Ala Val Glu Asn Ala Val Lys Ile Ala Arg Ala Ala Thr Lys Arg 
        115                 120                 125             


Ser Gly Thr Ile Ala Phe Ser Gly Ala Tyr His Gly Arg Thr His Tyr 
    130                 135                 140                 


Thr Leu Ala Leu Thr Gly Lys Val Asn Pro Tyr Ser Ala Gly Met Gly 
145                 150                 155                 160 


Leu Met Pro Gly His Val Tyr Arg Ala Leu Tyr Pro Cys Pro Leu His 
                165                 170                 175     


Gly Ile Ser Glu Asp Asp Ala Ile Ala Ser Ile His Arg Ile Phe Lys 
            180                 185                 190         


Asn Asp Ala Ala Pro Glu Asp Ile Ala Ala Ile Val Ile Glu Pro Val 
        195                 200                 205             


Gln Gly Glu Gly Gly Phe Tyr Ala Ser Ser Pro Ala Phe Met Gln Arg 
    210                 215                 220                 


Leu Arg Ala Leu Cys Asp Glu His Gly Ile Met Leu Ile Ala Asp Glu 
225                 230                 235                 240 


Val Gln Ser Gly Ala Gly Arg Thr Gly Thr Leu Phe Ala Met Glu Gln 
                245                 250                 255     


Met Gly Val Ala Pro Asp Leu Thr Thr Phe Ala Lys Ser Ile Ala Gly 
            260                 265                 270         


Gly Phe Pro Leu Ala Gly Val Thr Gly Arg Ala Glu Val Met Asp Ala 
        275                 280                 285             


Val Ala Pro Gly Gly Leu Gly Gly Thr Tyr Ala Gly Asn Pro Ile Ala 
    290                 295                 300                 


Cys Val Ala Ala Leu Glu Val Leu Lys Val Phe Glu Gln Glu Asn Leu 
305                 310                 315                 320 


Leu Gln Lys Ala Asn Asp Leu Gly Gln Lys Leu Lys Asp Gly Leu Leu 
                325                 330                 335     


Ala Ile Ala Glu Lys His Pro Glu Ile Gly Asp Val Arg Gly Leu Gly 
            340                 345                 350         


Ala Met Ile Ala Ile Glu Leu Phe Glu Asp Gly Asp His Asn Lys Pro 
        355                 360                 365             


Asp Ala Lys Leu Thr Ala Glu Ile Val Ala Arg Ala Arg Asp Lys Gly 
    370                 375                 380                 


Leu Ile Leu Leu Ser Cys Gly Pro Tyr Tyr Asn Val Leu Arg Ile Leu 
385                 390                 395                 400 


Val Pro Leu Thr Ile Glu Asp Ala Gln Ile Arg Gln Gly Leu Glu Ile 
                405                 410                 415     


Ile Ser Gln Cys Phe Asp Glu Ala Lys Gln 
            420                 425     


<210>  14
<211>  1365
<212>  DNA
<213>  Pseudomonas sp.

<400>  14
atgacgaaac agaccagcgc ccagacccaa cactggcagg cgctcagccg cgaacaccac       60

ctggctccgt tcaccgacta caagcaactg aacgagaagg gtgcgcgcat catcaccaag      120

gccgaaggcg tgtacctgtg ggacagcgag ggcaacaaga tcctcgatgg catggccggc      180

ctgtggtgca tgaacgtcgg ctatggtcgc aaggagcttg ccgaggtcgc ctacaagcag      240

atgctcgagc tgccctacta caacctgttc ttccagaccg cgcacccgcc agcgctggag      300

ctggccaagg ccatcgccga catcgccccc gaaggcatga accacgtgtt cttcaccggc      360

tccggctcgg agtccaacga caccgtgctg cgcatggtcc gccactactg gagcatcaag      420

ggcaagccgc agaagaaggt ggtcatcggc cgctggaacg gctaccacgg ctccaccgtc      480

gccggcgtca gcctcggcgg catgaaggcc ctgcacagcc agggcgacct gccgatcccg      540

ggcatcgtgc acatcgccca gccctactgg tacggcgagg gcggcgacat gtcggcggaa      600

gagttcggcg tctgggccgc cgagcagctg gagaagaaga ttctcgaagt cggcgaggag      660

aacgtcgccg ccttcatcgc cgagccgatc cagggcgccg gcggcgtgat cgttccgccg      720

gacacctact ggccgaagat ccgcgagatc ctcgccaagt acgaaatcct gttcatcgcc      780

gacgaagtca tctgcggctt cggccgtacc ggcgaatggt tcggcagcca gtactacggc      840

aacgccccgg acctgatgcc gatcgccaag ggcctgactt ccggctacat ccccatgggc      900

ggcgtaatcg tccgcgacga gatcgtcgat accctgaatg agggtggcga gttctaccac      960

ggcttcactt actctggtca cccggtggcc gcggcggtgg ccctggagaa catccgcatc     1020

ctgcgcgagg agaagatcgt cgagaccgtg aaggcggaaa cggcacctta cttgcaaaag     1080

cgctggcagg aactggccga ccacccgctg gtgggcgagg cccgcggcgt cggcatggtc     1140

ggcgcgctgg agctggtgaa gaacaagaag acccgcgagc gcttcgagaa cggcgtgggg     1200

atgctgtgcc gcgagcactg cttccgcaac ggcctgatca tgcgcgcggt gggagacact     1260

atgattattt cgccgccgct ggtcatcacc aagccggaga tcgacgagtt gatcaccctg     1320

gcgcgcaagt gcctcgatca aaccgccgcc gtagcgctgt cttga                     1365


<210>  15
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  15
atgaccgatt ttgatcagct gtttgaacag gatcgtgccc attttatgca tccgagcacc       60

catgcacatg atcacgcaag cggtgcactg cctggtcgta ttattaccgg tgcaagcggt      120

attcgtattc gcgatcatga aggtcgtgaa ctgattgatg catttgcagg tctgtattgc      180

gtgaatattg gttatggtcg taccgaagtt gcagatgcaa tctataaaca ggcaaaagag      240

ctggcctatt atcataccta tgttggtcat agcaccgaag ccattattga actgagcagc      300

cgtattattc gtgattgggc accggcaggt atgaaaaaag tttattatgg tctgagcggc      360

tccgatgcaa atgaaaccca gattaaactg gtgcgctatt ataacaatgt tctgggtcgt      420

ccgcagaaaa aaaaaatcat tagccgtcag cgtggttatc atggtagcgg tattatgacc      480

ggcagcctga ccggtctgcc gagctttcat cagcattttg atctgccggt tgaaggcatt      540

aaacataccg tttgtccgca ttggtataaa gctccggcag gcatggatga agcagcattt      600

gttcgttatt gtgcagatga actggaaaaa ctgattctgg cagaaggtcc ggataccgtt      660

gcagcattta ttggtgaacc ggttatgggt acaggtggta ttattgttcc gcctaaaggt      720

tattgggaag caattcaggc agtcctgaac aaatatgatg ttctgctgat tgccgatgaa      780

gttgtttgtg catttggtcg tctgggtagc aaaatgggta gccagcgtta tggtatgcgt      840

ccggatctga ttaccaccgc aaaaggtctg accagcgcct atgcaccgct gagcgcagtt      900

attgttggtg aaaaagtttg ggatgtgatc gaaaaagcaa gccagaaaga aggtgcaatg      960

ggtcatggtt ggacctatag cggtcatccg atttgtgcag cagcagcact ggcaaatctg     1020

gatattctgg aacgtgaaaa tctgaccgca aatgccgcag atgttggtgc atatctgaat     1080

cagcgtctgc gtgaaacctt tgaaggtcat ccgctggttg gtgaagttcg tggtgatggt     1140

atgctggcag ccctggaatt tatggcagat cgtgaagcac gtaccccgtt tgatccggca     1200

ctgaaagttg gtccgaaagt tagcgcagca tgtctggaag atggtatgat tgcacgtgcc     1260

atgccgcatg gtgatatcct gggttttgca ccgcctctgg ttctgacccg tgccgaagca     1320

gatgaaattg ttggtattgc aaaagcagcc gttgatgaag tggcaggcga agttctgtaa     1380


<210>  16
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  16
atgaccgatc tggatcagct gtttgaaatg gatcgtgcac attttatgca tccgagcacc       60

catgcacatg atcacgcaag cggtgcactg cctggtcgta ttattaccgg tggtaaaggt      120

attcgtatcc aggatcatga aggtcgcgaa tatattgatg catttgcagg tctgtattgc      180

gtgaatattg gttatggtcg taccgaagtt gcagatgcaa tttatgaaca ggcaaaagag      240

ctggcctatt atcataccta tgttggtcat agcaccgaag ccattattga actgagcagc      300

cgtattattc gtgattgggc accggcaggt atgaaaaaag tttattatgg tatgagcggt      360

agcgacgcaa atgaaaccca gattaaactg gtgtggtatt acaataatgt tctgggtcgt      420

ccgcagaaaa aaaaaatcat tagccgtcag cgtggttatc atggtagcgg tattatgacc      480

ggcagcctga ccggtctgcc gagctttcat cagcattttg atctgccgat tgaacgcatt      540

aaacataccg tttgtccgca ctggtataaa gctccggcag gcatgagcga agcacagttt      600

gttcgttatt gtgcagatga actggaaaaa ctgattctgg cagaaggtcc ggataccgtt      660

gcagcattta ttggtgaacc ggttatgggt acaggtggta ttattccgcc tccgcagggt      720

tattgggaag caattcaggc agttctgaac aaatatgata ttctgctgat tgccgatgaa      780

gtggtttgtg gttttggtcg tctgggtagc aaaatgggta gccagcatta tggcatgaaa      840

ccggatctga ttaccgttgc caaaggtctg accagcgcct atgcaccgct gagtggtgtt      900

attgttggtg aaaaagtttg ggacgtgatt gaaaaaggta gccaagaaca tggtccgatg      960

ggtcatggtt ggacctatag cggtcatccg atttgtgcag cagcagcact ggcaaatctg     1020

gatattctgg aacgtgaaaa tctgaccggt aatgcagcag atgttggtgc atatctgcag     1080

cagcgtctgc gtgaaacctt tggtggtcat ccgctggttg gtgaagttcg tggtgttggt     1140

atgctggcag ccctggaatt tatggcagat aaagatgcac gtaccccgtt tgatcctgcc     1200

ctgaaagttg gtccgaaagt tagcgcagca tgtctggaag atggtatgat tgcacgtgcc     1260

atgccgcatg gtgatatcct gggttttgca ccgcctctgg ttattacccg tgccgaagtt     1320

gatgaaattg ttggtattgc aaaacaggcc gttgatgaag ttgcggatga agttctgtaa     1380


<210>  17
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  17
atgcagagcc tggatcagct gtttgaaatg gatcgtgcac attttatgca tccgagcacc       60

catgcacatg atcacgcaag cggtgcactg cctggtcgta ttattaccgg tggtaaaggt      120

attcgcatcg aagatcatga aggtcgcgaa tatattgatg catttgcagg tctgtattgc      180

gtgaatattg gttatggtcg taccgaagtt gcagatgcaa tttatgaaca ggcaaaacag      240

ctggcctatt atcataccta tgttggtcat agcaccgatg ccattattga actgagcagc      300

cgtattattc gtgattgggc accggcaggt atgaaaaaag tttattatgg tatgagcggt      360

agcgacgcaa atgaaaccca gattaaactg gtgtggtatt acaataatgt tctgggtcgt      420

ccgaacaaaa aaaaaatcat tagccgtgaa cgcggttatc atggtagcgg tattgtgacc      480

ggtagcctga ccggtctgcc gagctttcat cagcattttg atctgccgat tgatcgtgtt      540

aaacataccg tttgtccgca ttggtatcgt gctccggcag gcatgagcga agcacagttt      600

gttgcatatt gtgttgagga actggaaaaa ctgattgcac gtgaaggtgc agataccatt      660

gcagcattta ttgcagaacc ggttatgggt acaggtggta ttattccgcc tccgcagggt      720

tattgggaag caattcaggc agttctgcgt aaacatgata ttctgctgat tgccgatgaa      780

gttgtttgtg gttttggtcg tctgggtagc aaaatgggta gccagcatta tggcattaaa      840

ccggatctga ttaccgttgc aaaaggtctg accagcgcct atgcaccgct gagtggtgtt      900

attgttggtg aaaaagtttg ggacgtgatt gaaaaaggta gccaagaaca tggtccgatg      960

ggtcatggtt ggacctatag cggtcatccg atttgtgcag cagcagcact ggcaaatctg     1020

gatattctgg aacgtgaaaa tctgaccggt aatgcagcag atgttggtgc atatctgcag     1080

cagcgtctgc atgaagcatt tggtgcacat ccgctggttg gtgaagttcg tggtgttggt     1140

atgctggcag ccctggaatt tatggcagat aaagatgcac gtaccccgtt tgatccggca     1200

ctgaaagttg gtccgaaagt tagcgcagcc gcactggaag atggtatgat tgcccgtgca     1260

atgccgcatg gtgatatcct gggttttgca ccgcctctgg ttaccacccg tgccgaagtt     1320

gatgaaattg ttggtattgc aaaacaggcc gttgatgaag tggcagatga agttctgtaa     1380


<210>  18
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  18
atgaccagcc tggatcagct gtttgaagaa gatcgcgcac attttatgca tccgagcacc       60

catgcacatg atcacgcaag cggtgcactg cctggcaaaa ttgttaccgg tggtaaaggt      120

attcgcatcg aagatcatca gggtcgcgaa tatattgatg catttgcagg tctgtattgc      180

gtgaatattg gttatggtcg taccgaagtt gcagatgcaa tttatgaaca ggcaaaacag      240

ctggcctatt atcataccta tgttggtcat agcaccgatg ccattattga actgagcagc      300

cgtattattc gtgattgggc accggcaggt atgaaaaaag tttattatgg tatgagcggt      360

agcgacgcaa atgaaaccca gattaaaatc gtgtggtact acaataatgt tctgggtcgt      420

ccgaacaaaa aaaaaatcat tagccgtgaa cgcggttatc atggtagcgg tattgtgacc      480

ggtagcctga ccggtctgcc gagctttcat cagcattttg atctgccgat tgatcgtgtt      540

aaacataccg tttgtccgca ctggtataaa gctccggcag gcatgagcga agcacagttt      600

gttgcatatt gtgttgagga actggaaaaa ctgattgcac gtgaaggtgc agataccatt      660

gcagcattta ttgcagaacc ggttatgggt acaggtggta ttattgcacc gcctcagggt      720

tattgggaag caattcaggc agttctgcgt aaacatgata ttctgctgat tagtgatgaa      780

gtggtttgtg gttttggtcg tctgggtagc aaaatgggtg cacagcatta tggcattaaa      840

ccggatctga ttaccgttgc aaaaggtctg accagcgcct atgcaccgct gagtggtgtt      900

attgttggtg aaaaagtttg ggacgtgatt gaaaaaggta gccaagaaca tggtccgatg      960

ggtcatggtt ggacctatag cggtcatccg atttgtgcag cagcagcact ggcaaatctg     1020

gatattctgg aacgtgaaaa tctgaccggt aatgcagcag atgttggtgc atatctgcag     1080

cagcgtctgc atgaagcatt tggtgcacat ccgctggttg gtgaagttcg tggtgttggt     1140

atgctggcag ccctggaatt tatggcagat aaagatgcac gtaccccgtt tgatcctgcc     1200

ctgaaagttg gtccgaaagt tagcgcagcc gcactggaag atggtgtgat tgcccgtgca     1260

atgccgcatg gtgatatcct gggttttgca ccaccgctgg ttaccacccg tgccgaagtt     1320

gatgaaattg ttggtattgt taaacaggcc gttgatgaag ttgccgatga agttctgtaa     1380


<210>  19
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  19
atgaccagcc tggaacagct gctggaaatg gatcgtgcac attttatgca tccgagcacc       60

catgcctatg atcatgcaag cggtgcactg cctggtcgta ttattaccgg tggtaaaggt      120

attcgcatcg aagatcatga aggtcgcgaa tatattgatg catttgcagg tctgtattgc      180

gtgaatattg gttatggtcg tgaagaggtt gcagatgcaa tttatgaaca ggcaaaacag      240

ctggcctatt atcataccta tgttggccat agcaatgatc cggttattga actgagcagc      300

cgtattattg aagattgggc accggcaggt atgaaaaaag ttttttatgg tatgagcggt      360

agcgacgcaa atgaaaccca gattaaactg gtgtggtatt acaataatgt tctgggtcgt      420

ccgaacaaaa aaaaaatcat tgcacgtgaa cgcagctatc atggtagcgg tattgtgacc      480

ggtagcctga ccggtctgcc gagctttcat cagcattttg atctgccgat tgatcgtgtt      540

aaacataccg tttgtccgca ttggtataat gcacctccgg gtatgagtga agcacagttt      600

gttgcatatt gtgtggaaga actggaaaaa ctgattgccc gtgaaggtgc agataccatt      660

gcagcattta ttgcagaacc ggttatgggt acaggtggta ttgttccgcc tccgcagggt      720

tattgggaag caattcaggc agttctgcgt aaacatgata ttctgctgat tgccgatgaa      780

gttgtttgtg gttttggtcg tctgggtagc aaaaccggta gcgaacatta tggtattaaa      840

ccggatctga ttaccgttgc aaaaggtctg accagcgcct atgcaccgct gagcgcagtt      900

attgttagcg aaaaagtttg ggatgtgatc gaaaaaggta gccgtgaaca tggtgttatg      960

ggtcatggtt ggacctatag cggtcatccg gtttgtgcag cagcagcact ggcaaatctg     1020

gatattctgg aacgtgaaaa tctgaccggt aatgcagcag atgttggtgc atatctgcag     1080

cagcgtctgc atgaagcatt tggtgcacat ccgctggttg gtgaagttcg tggtgttggt     1140

atgctggcag ccctggaatt tatggcagat aaaggtgcac gtaccccgtt tgatccggca     1200

ctgaaagtta gccagaaagt tgcagccgca gcgctggaag atggtctgat tgttcgtgcc     1260

ctgccgcatg gtgatatcct gggttttgca ccgcctctgg ttaccacccg tgccgaagtt     1320

gatgaaattg ttgcaattgc caaagaagcc tttgacgaag ttgcggatgc agttctgtaa     1380


<210>  20
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Molecule produced by ancestral reconstruction

<400>  20
atgaccgata ccgatgatct gctggaaatg gatcgtgcac atttttttca tccgagcacc       60

catctgcgtg atcatgcaag cggtgaactg cctggtcgta ttattaccgg tggtaaaggt      120

attcgtattc aggatagcga aggtcgcgaa tatattgatg catttgcagg tctgtattgc      180

gtgaatgttg gttatggtcg taccgaaatt gcagatgcca tttatgaaca ggcaaaagag      240

ctggcctatt atcataccta tgttggccat agcaacgaac cgattattga actgagcgaa      300

cgtattattc gtgaatgggc accggcaggt atgagcaaag tttattatgg tatgagcggt      360

tccgatgcaa atgaaaccca gattaaactg gtgtggtatt acaataatgt tctgggtcgt      420

ccgcagaaaa aaaaaatcat tagccgtcag cgtggttatc atggtagcgg tattatgacc      480

ggcagcctga ccggtctgcc tgcatttcat aatcattttg atctgccgct ggaaccgatt      540

cgtcatacca cctgtccgca ttattatcgt gctccggcag gcatgtcaga agcagaattt      600

agtcgtcatt gtgcagatga gctggaaaaa atgattctgg cagaaggtcc ggataccgtt      660

gcagcattta ttggtgaacc ggttatgggt acgggtggta ttgttccgcc tccggaaggt      720

tattgggaag caattcaggc cgttctgaac aaatatgata ttctgctgat tgccgatgaa      780

gtggtttgtg gttttggtcg caccggtagc atgtttggta gccatcatta tggcatgaaa      840

ccggatctga ttaccgttgc caaaggtctg accagcgcct atgcaccgct gagtggtgtt      900

attgttggtg aaaaagtttg gaaagttctg gaacagggta gcgatcagta tggtccgatt      960

ggtcatggtt ggacctatag cggtcatccg atttgtgcag cagcagcact ggcaaatctg     1020

gatattatcg aacgtgaaaa tctgaccggt aatgcagcag ataccggtgc ctattttcag     1080

cagcgtatgc gtgaaacctt tggtgatcat ccgctggttg gtgaagttcg tggtgttggt     1140

ctgatggcag ccctggaatt tgttgcagat aaagataaac gtacccgttt tgatccgagc     1200

ctgaaagttg gtccgcgtgt tagcgcagca tgtctggaag atggtatgat tgcacgtgcc     1260

atgccgcatg gtgatatcct gggttttgca ccgcctctgg ttattacccg tgccgaagtt     1320

gatgaaattg tggatattgc aaaacaggca gttgatgccg ttgcggatga actggtgtaa     1380


