                         SEQUENCE LISTING

<110>  Jain, Sanjay K
       Skerry, Ciaran
       Be, Nicholas A
 
<120>  VACCINATION WITH RECOMBINANT MYCOBACTERIUM TUBERCULOSIS PknD 
       ATTENUATES BACTERIAL DISSEMINATION TO THE BRAIN

<130>  111232-00284

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  664
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  1

Met Ser Asp Ala Val Pro Gln Val Gly Ser Gln Phe Gly Pro Tyr Gln 
1               5                   10                  15      


Leu Leu Arg Leu Leu Gly Arg Gly Gly Met Gly Glu Val Tyr Glu Ala 
            20                  25                  30          


Glu Asp Thr Arg Lys His Arg Val Val Ala Leu Lys Leu Ile Ser Pro 
        35                  40                  45              


Gln Tyr Ser Asp Asn Ala Val Phe Arg Ala Arg Met Gln Arg Glu Ala 
    50                  55                  60                  


Asp Thr Ala Gly Arg Leu Thr Glu Pro His Ile Val Pro Ile His Asp 
65                  70                  75                  80  


Tyr Gly Glu Ile Asn Gly Gln Phe Phe Val Glu Met Arg Met Ile Asp 
                85                  90                  95      


Gly Thr Ser Leu Arg Ala Leu Leu Lys Gln Tyr Gly Pro Leu Thr Pro 
            100                 105                 110         


Ala Arg Ala Val Ala Ile Val Arg Gln Ile Ala Ala Ala Leu Asp Ala 
        115                 120                 125             


Ala His Ala Asn Gly Val Thr His Arg Asp Val Lys Pro Glu Asn Ile 
    130                 135                 140                 


Leu Val Thr Ala Ser Asp Phe Ala Tyr Leu Val Asp Phe Gly Ile Ala 
145                 150                 155                 160 


Arg Ala Ala Ser Asp Pro Gly Leu Thr Gln Thr Gly Thr Ala Val Gly 
                165                 170                 175     


Thr Tyr Asn Tyr Met Ala Pro Glu Arg Phe Thr Gly Asp Glu Val Thr 
            180                 185                 190         


Tyr Arg Ala Asp Ile Tyr Ala Leu Ala Cys Val Leu Gly Glu Cys Leu 
        195                 200                 205             


Thr Gly Ala Pro Pro Tyr Arg Ala Asp Ser Val Glu Arg Leu Ile Ala 
    210                 215                 220                 


Ala His Leu Met Asp Pro Ala Pro Gln Pro Ser Gln Leu Arg Pro Gly 
225                 230                 235                 240 


Arg Val Pro Pro Ala Leu Asp Gln Val Ile Ala Lys Gly Met Ala Lys 
                245                 250                 255     


Asn Pro Ala Glu Arg Phe Met Ser Ala Gly Asp Leu Ala Ile Ala Ala 
            260                 265                 270         


His Asp Ala Leu Thr Thr Ser Glu Gln His Gln Ala Thr Thr Ile Leu 
        275                 280                 285             


Arg Arg Gly Asp Asn Ala Thr Leu Leu Ala Thr Pro Ala Asp Thr Gly 
    290                 295                 300                 


Leu Ser Gln Ser Glu Ser Gly Ile Ala Gly Ala Gly Thr Gly Pro Pro 
305                 310                 315                 320 


Thr Pro Gly Ala Ala Arg Trp Ser Pro Gly Asp Ser Ala Thr Val Ala 
                325                 330                 335     


Gly Pro Leu Ala Ala Asp Ser Arg Gly Gly Asn Trp Pro Ser Gln Thr 
            340                 345                 350         


Gly His Ser Pro Ala Val Pro Asn Ala Leu Gln Ala Ser Leu Gly His 
        355                 360                 365             


Ala Val Pro Pro Ala Gly Asn Lys Arg Lys Val Trp Ala Val Val Gly 
    370                 375                 380                 


Ala Ala Ala Ile Val Leu Val Ala Ile Val Ala Ala Ala Gly Tyr Leu 
385                 390                 395                 400 


Val Leu Arg Pro Ser Trp Ser Pro Thr Gln Ala Ser Gly Gln Thr Val 
                405                 410                 415     


Leu Pro Phe Thr Gly Ile Asp Phe Arg Leu Ser Pro Ser Gly Val Ala 
            420                 425                 430         


Val Asp Ser Ala Gly Asn Val Tyr Val Thr Ser Glu Gly Met Tyr Gly 
        435                 440                 445             


Arg Val Val Lys Leu Ala Thr Gly Ser Thr Gly Thr Thr Val Leu Pro 
    450                 455                 460                 


Phe Asn Gly Leu Tyr Gln Pro Gln Gly Leu Ala Val Asp Gly Ala Gly 
465                 470                 475                 480 


Thr Val Tyr Val Thr Asp Phe Asn Asn Arg Val Val Thr Leu Ala Ala 
                485                 490                 495     


Gly Ser Asn Asn Gln Thr Val Leu Pro Phe Asp Gly Leu Asn Tyr Pro 
            500                 505                 510         


Glu Gly Leu Ala Val Asp Thr Gln Gly Ala Val Tyr Val Ala Asp Arg 
        515                 520                 525             


Gly Asn Asn Arg Val Val Lys Leu Ala Ala Gly Ser Lys Thr Gln Thr 
    530                 535                 540                 


Val Leu Pro Phe Thr Gly Leu Asn Asp Pro Asp Gly Val Ala Val Asp 
545                 550                 555                 560 


Asn Ser Gly Asn Val Tyr Val Thr Asp Thr Asp Asn Asn Arg Val Val 
                565                 570                 575     


Lys Leu Glu Ala Glu Ser Asn Asn Gln Val Val Leu Pro Phe Thr Asp 
            580                 585                 590         


Ile Thr Ala Pro Trp Gly Ile Ala Val Asp Glu Ala Gly Thr Val Tyr 
        595                 600                 605             


Val Thr Glu His Asn Thr Asn Gln Val Val Lys Leu Leu Ala Gly Ser 
    610                 615                 620                 


Thr Thr Ser Thr Val Leu Pro Phe Thr Gly Leu Asn Thr Pro Leu Ala 
625                 630                 635                 640 


Val Ala Val Asp Ser Asp Arg Thr Val Tyr Val Ala Asp Arg Gly Asn 
                645                 650                 655     


Asp Arg Val Val Lys Leu Thr Ser 
            660                 


<210>  2
<211>  262
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  2

Arg Pro Ser Trp Ser Pro Thr Gln Ala Ser Gly Gln Thr Val Leu Pro 
1               5                   10                  15      


Phe Thr Gly Ile Asp Phe Arg Leu Ser Pro Ser Gly Val Ala Val Asp 
            20                  25                  30          


Ser Ala Gly Asn Val Tyr Val Thr Ser Glu Gly Met Tyr Gly Arg Val 
        35                  40                  45              


Val Lys Leu Ala Thr Gly Ser Thr Gly Thr Thr Val Leu Pro Phe Asn 
    50                  55                  60                  


Gly Leu Tyr Gln Pro Gln Gly Leu Ala Val Asp Gly Ala Gly Thr Val 
65                  70                  75                  80  


Tyr Val Thr Asp Phe Asn Asn Arg Val Val Thr Leu Ala Ala Gly Ser 
                85                  90                  95      


Asn Asn Gln Thr Val Leu Pro Phe Asp Gly Leu Asn Tyr Pro Glu Gly 
            100                 105                 110         


Leu Ala Val Asp Thr Gln Gly Ala Val Tyr Val Ala Asp Arg Gly Asn 
        115                 120                 125             


Asn Arg Val Val Lys Leu Ala Ala Gly Ser Lys Thr Gln Thr Val Leu 
    130                 135                 140                 


Pro Phe Thr Gly Leu Asn Asp Pro Asp Gly Val Ala Val Asp Asn Ser 
145                 150                 155                 160 


Gly Asn Val Tyr Val Thr Asp Thr Asp Asn Asn Arg Val Val Lys Leu 
                165                 170                 175     


Glu Ala Glu Ser Asn Asn Gln Val Val Leu Pro Phe Thr Asp Ile Thr 
            180                 185                 190         


Ala Pro Trp Gly Ile Ala Val Asp Glu Ala Gly Thr Val Tyr Val Thr 
        195                 200                 205             


Glu His Asn Thr Asn Gln Val Val Lys Leu Leu Ala Gly Ser Thr Thr 
    210                 215                 220                 


Ser Thr Val Leu Pro Phe Thr Gly Leu Asn Thr Pro Leu Ala Val Ala 
225                 230                 235                 240 


Val Asp Ser Asp Arg Thr Val Tyr Val Ala Asp Arg Gly Asn Asp Arg 
                245                 250                 255     


Val Val Lys Leu Thr Ser 
            260         


