                         SEQUENCE LISTING

<110>  University Health Network
       Mak, Tak
       Lai, Xiuqui
       Tusche, Michael W.
 
<120>  ANTIBODIES TO TOSO

<130>  L80008647WO

<140>  PCT/CA14/000537
<141>  2014-07-02

<150>  US 61/842,766
<151>  2013-07-03

<160>  244   

<170>  PatentIn version 3.5

<210>  1
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Asp Phe Ile Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Phe Ile Asp Thr Ser Thr Tyr Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Thr Asp Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Gly Ser Ser Tyr Trp Gly Gly His Tyr Phe His 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Lys 
    130                 


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ser Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ala Pro Ser Leu Leu Ile 
        35                  40                  45              


His Asp Ala Ser Asn Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Gly Pro Pro 
                85                  90                  95      


Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ala Ala 
        115                 120 


<210>  3
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  3

Ala Gly Ala Ala Gly Ala Val Trp Gly Asp Val Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Glu Gly Ser Gly Phe Ser Phe Ser Asp Phe 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Arg Tyr Asp Gly Ser Lys Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val His 
65                  70                  75                  80  


Leu Glu Leu Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Glu Met Ala Arg Trp Ala Tyr Val Asp Trp Leu Pro His 
            100                 105                 110         


Leu His His Ser Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Lys 
    130                 135                 


<210>  4
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  4

Val Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe 
        115         


<210>  5
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  5

Ala Gly Ala Ala Gly Ala Val Trp Gly Asp Val Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Glu Gly Ser Gly Phe Ser Phe Ser Asp Phe 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Arg Tyr Asp Gly Ser Lys Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val His 
65                  70                  75                  80  


Leu Glu Leu Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Glu Met Ala Arg Trp Ala Tyr Val Asp Trp Leu Pro His 
            100                 105                 110         


Leu His His Ser Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Lys 
    130                 135                 


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  6

Val Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Asn Glu Leu Trp Leu 
            100                 105                 110         


His His Leu Ser 
        115     


<210>  7
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Phe Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Lys Arg Asp Ala Thr Ser Thr Thr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Gly Gly Tyr Thr Tyr Gly Gly Val Tyr Tyr Tyr Asn Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Lys 
    130             


<210>  8
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  8

Asp Ile Glu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Ser Ser 
            20                  25                  30          


Ser Tyr Ser Glu Asp Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Val Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ile Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala His Met Ser Ser Arg Pro 
        115                 120                 


<210>  9
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  9

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Asp Phe Ile Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Phe Ile Asp Thr Ser Thr Tyr Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Thr Asp Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Gly Ser Ser Tyr Trp Gly Gly His Tyr Phe His 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Lys 
    130                 


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  10

Val Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ser Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile His Asp Ala Ser Asn Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Thr Gly Leu 
                85                  90                  95      


Arg Val Gly Arg Ser Ala Lys Gly Pro Arg Trp Lys Ser Asn Gly Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe 
        115                 


<210>  11
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  11

Gly Gly Ala Ala Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Gly Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Pro Tyr Thr Ser Gly Trp Tyr Val Gly Cys Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys 
        115                 120                 125             


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  12

Val Glu Ile Val Leu Thr Gln Ser Pro Arg Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                85                  90                  95      


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asp Cys 
            100                 105                 110         


Gly Cys Thr Ile Cys Leu 
        115             


<210>  13
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  13

Gly Gly Ala Ala Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Cys 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Ser Gly Leu Ser Thr Tyr Tyr Thr Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Ser Thr Met Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Ser Ala Gly Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Pro Trp Asp Tyr Tyr Gly Ser Gly Asn Thr Asp His Phe 
            100                 105                 110         


Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Lys 
    130         


<210>  14
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  14

Val Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Arg Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Thr Tyr Arg Ala Ala Gly Ile Pro Ala Arg Ile Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Asn Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg Arg Leu Trp Leu 
            100                 105                 110         


His His Leu Ser 
        115     


<210>  15
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  15

Gly Gly Ala Ala Val Gly Val Trp Gly Arg Leu Gly Thr Ala Trp Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Thr Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Arg Gly Ser Ser Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Leu Phe Thr Val Ser Arg Asp Asn Phe Lys Asn Met Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Leu Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys 
        115                 120             


<210>  16
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  16

Val Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                85                  90                  95      


Pro Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Lys Leu 
            100                 105                 110         


Trp Leu His His Leu Ser 
        115             


<210>  17
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  17

Gly Gly Ala Ala Val Glu Ser Gly Gly Glu Leu Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Thr Ser Gly Tyr Asp Phe Ala Asn Phe 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Pro Asp Asp Ser Asp Val Asn Tyr Ser Pro Gly Phe 
    50                  55                  60                  


Gln Gly His Val Ala Ile Ser Ala Asp Lys Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Trp Ser Ser Leu Lys Ala Ser Asp Ser Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Tyr Ser Gly Ala Gln Leu Gly Val Asp Ser Trp Gly Leu 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Arg Ala Gln 
        115                 120                 125     


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Arg Arg Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Asn Thr 
            20                  25                  30          


Gly Tyr Leu Ala Xaa Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Arg Val 
65                  70                  75                  80  


Gly Pro Asp Asp Phe Ala Ile Tyr Tyr Cys Gln Gln His Gly Thr Ser 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gln Gly Xaa Arg Leu Xaa Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Thr Ile Cys Leu 
        115             


<210>  19
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain


<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Val Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Asn Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Xaa Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Leu Arg Trp Leu Arg Pro Thr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Lys 
    


<210>  20
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain


<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Val Asp Ile Glu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr His 
            20                  25                  30          


Ser Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Xaa Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Xaa Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Xaa Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Val Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


His Leu Ser 
        115 


<210>  21
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  21

Ala Gly Ala Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Ser Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Gly Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Ser Gly Val Gly Tyr Gln Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Pro Arg Asp His Gly His Arg Phe Leu Arg Leu His Gln Gly 
        115                 120                 125             


Pro Lys 
    130 


<210>  22
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  22

Val Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Val Leu Tyr 
            20                  25                  30          


Asn Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Thr Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Tyr Gly Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Arg Arg Leu Trp Leu His His Leu Ser 
        115                 120             


<210>  23
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  23

Ala Gly Gln Leu Val Gln Ser Gly Ala Glu Ala Arg Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Leu Ser Asp Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Thr Arg Asp Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gly Thr Thr Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Arg Tyr Asp Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gly Phe Cys Thr Ile Asp Asn Cys His Asp Phe Phe Asp 
            100                 105                 110         


Ser Trp Gly His Gly Ser Leu Ile Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Lys 
    130     


<210>  24
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  24

Val Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu 
1               5                   10                  15      


Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Val Tyr 
            20                  25                  30          


Ser Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Ser Thr Asp Trp Pro Trp Thr Phe Gly Gln Gly Thr Arg Val Glu 
            100                 105                 110         


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
        115                 120             


<210>  25
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  25

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Lys Thr Gly Gly Thr Asn Tyr Ala Gln His Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Leu Asn Leu Tyr Tyr Asp Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Lys 
    


<210>  26
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  26

Val Asp Ile Val Met Thr Gln Ala Pro Leu Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Arg Ser Val Leu Tyr 
            20                  25                  30          


Thr Ser Thr Asn Arg Tyr Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Tyr Asn Pro Pro Val Tyr Thr Phe Gly Gln Gly Thr Arg Leu 
            100                 105                 110         


Glu Ile Lys Lys Thr Val Ala Ala Pro Ser Val Phe 
        115                 120                 


<210>  27
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ala Cys Ser Val Ser Gly Ala Leu Val Thr Asn Thr 
            20                  25                  30          


Ala Tyr Tyr Trp Gly Trp Phe Arg Gln Ser Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Cys Ile Tyr Ala Asn Gly Arg Thr Tyr Thr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Leu Ser Ile Asp Gln Ser Arg Gln Arg Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Thr Ser Ala Thr Ala Thr Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Arg Leu Val Pro Lys Arg Thr Ala Thr Leu His Tyr Tyr Ile 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ala 
        115                 120                 125             


Ser Ala Pro Lys 
    130         


<210>  28
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  28

Val Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser Ala Ser Leu Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu 
        35                  40                  45              


Met Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asn Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp 
                85                  90                  95      


Gly Thr Gly Ile His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly Gln Pro Lys Ala Pro Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             


Ser 
    


<210>  29
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Asn Val Ser Cys Lys Ala Ser Gly Asp Thr Ser Ser Ile Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Ile Pro Arg Ile Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Ile Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Cys Ser Gly Gly Ser Cys Phe Arg Gln Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Ile Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Lys 
    130     


<210>  30
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain


<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(108)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Ile Leu Ser Gln Ala Pro Leu Ser Leu Ser Ala Ser Ile Gly Asp Ser 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asp Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        35                  40                  45              


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ile Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Xaa 
65                  70                  75                  80  


Phe Ala Thr Tyr Tyr Cys Xaa Gln Ser Tyr Thr Thr Ala Tyr Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Gln Arg Xaa Xaa Ala Ala Pro Ser 
            100                 105                 110         


Val Phe 
        


<210>  31
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Asn Val Ser Cys Lys Ala Ser Gly Asp Thr Ser Ser Ile Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Ile Pro Arg Ile Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Ile Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Cys Ser Gly Gly Ser Cys Phe Arg Gln Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Ile Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Lys 
    130     


<210>  32
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  32

Ile Leu Ser Gln Ala Pro Leu Ser Leu Ser Ala Ser Ile Gly Asp Ser 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asp Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        35                  40                  45              


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ile Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
65                  70                  75                  80  


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Ala Tyr Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Gln Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe 
        


<210>  33
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ser Tyr 
            20                  25                  30          


Asp Val Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ser Ile Ile Asn His Tyr Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Gly His Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Lys 
    


<210>  34
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  34

Val Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe 
        115         


<210>  35
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  35

Met Ala Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Asp Phe Ile Phe Asn 
            20                  25                  30          


Asn Tyr Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ser Phe Ile Asp Thr Ser Thr Tyr Thr Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Thr Leu Thr Asp Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Arg Tyr Gly Ser Ser Tyr Trp Gly Gly His Tyr 
            100                 105                 110         


Phe His Ala Met Asp Val Trp Gly Gln Gly Thr Pro Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Lys 
    130                 135     


<210>  36
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain


<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Val Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ser Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile His Asp Ala Ser Asn Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Xaa Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Gly Pro 
                85                  90                  95      


Pro Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe 
        115                 


<210>  37
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  37

Ala Gly Ala Ala Gly Ala Val Trp Gly Arg Pro Gly Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Asn Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Ser Ile Ser Ser Gly Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Tyr Tyr His Asp Ser Asp Glu Tyr Tyr Asp Ala Asp 
            100                 105                 110         


Gly Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Lys 
    130                 


<210>  38
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  38

Val Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Ser 
                85                  90                  95      


Leu Ser Ala Glu Gly Pro Arg Trp Arg Ser Asn Glu Leu Trp Leu His 
            100                 105                 110         


His Leu Ser 
        115 


<210>  39
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  39

Glu Val Gln Leu Leu Glu Ser Gly Glu Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Asn Gly Gly Thr Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Lys Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Leu Trp Phe Gly Glu Tyr Ile Phe Asp Cys Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Ser Val Ser Ser Leu His Gln Gly Pro Lys 
        115                 120                 125         


<210>  40
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  40

Val Asp Ile Glu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Ser 
            20                  25                  30          


Ser Ser Tyr Ser Glu Asp Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Val Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Tyr Ile Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu 
            100                 105                 110         


Ile Thr Asn Cys Gly Cys Thr Ile Cys Leu 
        115                 120         


<210>  41
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  41

Gly Gly Ala Val Val Gln Ser Gly Gly Gly Met Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Ala 
            20                  25                  30          


Trp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Arg Thr Gly Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ala Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Asn Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Val Trp Ser Gly Arg Asn Trp Phe Gly His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys 
        115                 120                 125     


<210>  42
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain


<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Val Asp Ile Val Met Thr Gln Ala Pro Leu Ser Ser Pro Val Thr Leu 
1               5                   10                  15      


Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
            20                  25                  30          


Ser Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Pro Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gln Thr Asp Ser Val Ala Val Gly Gln Gly Gln Ile Ser His Lys Ser 
65                  70                  75                  80  


Ala Gly Trp Lys Leu Arg Met Ser Gly Phe Ile Thr Ala Cys Lys Leu 
                85                  90                  95      


His Asn Phe Leu Thr Leu Leu Ala Arg Gly Xaa Ser Trp Arg Ser Lys 
            100                 105                 110         


Lys Thr Val Ala Ala Pro Ser Val Phe 
        115                 120     


<210>  43
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ser Tyr 
            20                  25                  30          


Asp Val Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ser Ile Ile Asn His Tyr Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Ala Thr Gly Pro Arg Ser Pro Ser Pro Gln Pro Pro Pro Arg Ala Gln 
        115                 120                 125             


<210>  44
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  44

Val Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Ser Ile Ser Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Arg Lys Ala Pro Asn Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95      


Glu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe 
        115         


<210>  45
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  45

Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala 
1               5                   10                  15      


Ser Asp Phe Ile Phe Asn Asn Tyr Asn Met Asn Trp Val Arg Gln Ala 
            20                  25                  30          


Pro Gly Lys Gly Leu Glu Trp Leu Ser Phe Ile Asp Thr Ser Thr Tyr 
        35                  40                  45              


Thr Thr Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg 
    50                  55                  60                  


Asp Asn Ser Lys Lys Ser Leu Phe Leu Gln Met Asn Thr Leu Thr Asp 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Asp Arg Tyr Gly Ser Ser 
                85                  90                  95      


Tyr Trp Gly Ala Thr Ile Ser Thr Leu Trp Thr Ser Gly Gly Lys Gly 
            100                 105                 110         


Pro Arg Ser Pro Ser Pro Gln Pro Pro Pro Arg Ala Gln 
        115                 120                 125 


<210>  46
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  46

Arg Arg Tyr Cys Asp Asp Ser Gly Ser Thr Leu Thr Val Cys Ile Cys 
1               5                   10                  15      


Arg Arg Gln Ser His Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95      


Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe 
        115         


<210>  47
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  47

Ala Gly Glu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Gln Ile Ser Cys Thr Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Ser Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Ile Met Ser Val Asp Lys Tyr Arg Asn Ile Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr Leu 
            100                 105                 110         


Ile Asp Asn Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ala Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Lys 
    130             


<210>  48
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  48

Val Asp Ile Glu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Ser 
            20                  25                  30          


Ser Ser Tyr Ser Glu Asp Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Val Glu Asp Val Ala Val Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Tyr Ile Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu 
            100                 105                 110         


Ile Lys Arg Thr Val Ala Ala His Met Ser Ser 
        115                 120             


<210>  49
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  49

Ala Gly Glu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Gln Ile Ser Cys Thr Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Ser Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Ile Met Ser Val Asp Lys Tyr Arg Asn Ile Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr Leu 
            100                 105                 110         


Ile Asp Asn Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ala Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Lys 
    130             


<210>  50
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  50

Val Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Gly Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ala Lys Thr Ser Gly Pro Gln Gly Ser Gln Thr Asp Ser Leu Ala Pro 
    50                  55                  60                  


Ala Gln Glu Thr Gln Leu Thr Pro Ser Leu Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ser Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Asp Asn Leu Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Arg Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Arg Ala Leu Cys Ser Thr Pro Leu 
        115                 120         


<210>  51
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ser Tyr 
            20                  25                  30          


Asp Val Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ser Ile Ile Asn His Tyr Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Gly His Gly Thr Thr Val Thr Val Ser Ser Ala Ser Pro Arg Ala Gln 
        115                 120                 125             


<210>  52
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  52

Arg Arg Tyr Cys Glu Thr Gln Ala Pro Leu Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Gly Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro 
                85                  90                  95      


Pro Gly Ser Pro Ser Ala Lys Gly His Asp Arg Arg Leu Asn Glu Leu 
            100                 105                 110         


Trp Leu His His Leu Ser 
        115             


<210>  53
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  53

Ala Gly Glu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Gln Ile Ser Cys Thr Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Ser Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Ile Met Ser Val Asp Lys Tyr Arg Asn Ile Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr Leu 
            100                 105                 110         


Ile Asp Asn Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ala Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Lys 
    130             


<210>  54
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain


<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<400>  54

Val Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Gly Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ala Lys Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Tyr Leu Thr Ile Thr Gly Ala Gln Ala Xaa 
65                  70                  75                  80  


Asp Glu Ser Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Asp Asn Leu 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Gly Thr Leu Phe His Pro Pro 
        115                 120             


<210>  55
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  55

Ala Gly Glu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Gln Ile Ser Cys Thr Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Ser Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Ile Met Ser Val Asp Lys Tyr Arg Asn Ile Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr Leu 
            100                 105                 110         


Ile Asp Asn Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ala Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Lys 
    130             


<210>  56
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  56

Val Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Gly Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ala Lys Thr Ser Gly Pro Gln Gly Ser Gln Thr Asp Ser Leu Ala Pro 
    50                  55                  60                  


Ala Gln Glu Thr Gln Leu Thr Pro Ser Leu Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ser Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Asp Asn Leu Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly His Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Gly Thr Leu Phe His Pro Pro 
        115                 120         


<210>  57
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  57

Ala Gly Glu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Gln Ile Ser Cys Thr Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Ser Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Ile Met Ser Val Asp Lys Tyr Arg Asn Ile Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr Leu 
            100                 105                 110         


Ile Asp Asn Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ala Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Lys 
    130             


<210>  58
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  58

Val Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Gly Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ala Lys Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Tyr Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ser Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Asp Asn Leu 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Gly Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 


<210>  59
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  59

Ala Gly Thr Ala Ala Ala Val Trp Gly Arg Leu Gly Thr Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Arg Thr Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Ala Thr Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Ser Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Arg Ile Ala Ile Glu Val Ala Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys 
        115                 120                 125         


<210>  60
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  60

Leu Arg Leu His Ser Ser Leu Ala Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Ser 
        35                  40                  45              


Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala 
65                  70                  75                  80  


Leu Tyr Phe Cys Gln Gln Ser Tyr Ile Tyr Leu Thr Phe Gly Gly Gly 
                85                  90                  95      


Thr Arg Val Glu Ile Lys Arg Leu Trp Leu His His Leu Ser 
            100                 105                 110 


<210>  61
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  61

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Phe Ile Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Phe Ile Asp Thr Ser Thr Tyr Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Thr Asp Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Gly Ser Ser Tyr Trp Gly Gly His Tyr Phe His 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Lys 
    130                 


<210>  62
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  62

Val Glu Ile Val Leu Thr Gln Ser Pro Pro Thr Leu Ser Val Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val 
        115     


<210>  63
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  63

Ala Gly Ala Ala Gly Ala Val Trp Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Ile Asn Gly Tyr 
            20                  25                  30          


Asp Leu Ser Trp Val Arg Gln Ala Arg Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Thr Gly Thr Thr Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Asp Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Trp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
        115                 120                 125             


<210>  64
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  64

Arg Arg Tyr Cys Asp Ala Gln Thr Pro Leu Ser Leu Pro Val Thr Leu 
1               5                   10                  15      


Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr 
            20                  25                  30          


Ser Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Gly Thr His Trp Pro Pro Tyr Thr Phe Gly Gln Gly Thr Arg Leu Glu 
            100                 105                 110         


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
        115                 120             


<210>  65
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Leu Glu Thr Arg Tyr Arg Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Leu Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Glu Ala Ser Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Tyr Tyr Asp Thr Thr Ala Tyr Ser Leu Tyr Tyr Tyr 
            100                 105                 110         


Pro Met Asp Val Trp Gly Gln Gly Pro Arg Ser Ser Ser Pro Gln Pro 
        115                 120                 125             


Pro Pro Arg Ala Gln 
    130             


<210>  66
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  66

Val Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Glu Lys Tyr 
            20                  25                  30          


Val Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Ala Val Ile 
        35                  40                  45              


Tyr Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala 
    50                  55                  60                  


Ser Asn Ser Ala Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala 
65                  70                  75                  80  


Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Gln Ala Trp Asp 
                85                  90                  95      


Ser Asn Thr Val Phe Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Ser 
            100                 105                 110         


Gln Pro Lys Ala Ala His Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125         


<210>  67
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Asp Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Gly Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Thr Ala Ser Asp Thr His Tyr Ala Gly Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Arg Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Ser Ile Ala Ala His Val Val Gly Ile Asn Met Asp Val Trp 
            100                 105                 110         


Gly Arg Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Lys 
    


<210>  68
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  68

Val Asp Ile Glu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Glu Asp Cys Gly Cys 
            100                 105                 110         


Thr Ile Cys Leu Arg Gly Arg Trp Ile Gln Arg Tyr Gln Ser Asn Cys 
        115                 120                 125             


Lys Leu 
    130 


<210>  69
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable heavy chain


<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<400>  69

Ala Gly Glu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Gln Ile Ser Cys Thr Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Ser Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Ile Met Ser Val Asp Lys Tyr Arg Asn Ile Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Asn Xaa Leu Lys Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr Leu 
            100                 105                 110         


Ile Asp Asn Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ala Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Lys 
    130             


<210>  70
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso-binding variable light chain

<400>  70

Val Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Gly Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ala Lys Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Tyr Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ser Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Asp Asn Leu 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Ala Gln 
            100                 105                 110         


Gly Cys Pro Leu Gly His Ser Val Pro Pro Ser Ser 
        115                 120                 


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  71

Asp Phe Ile Phe Asn Asn Tyr Asn 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  72

Ile Asp Thr Ser Thr Tyr Thr Thr 
1               5               


<210>  73
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  73

Ala Arg Asp Arg Tyr Gly Ser Ser Tyr Trp Gly Gly His Tyr Phe His 
1               5                   10                  15      


Ala Met Asp Val 
            20  


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  74

Gly Phe Ser Phe Ser Asp Phe Gly 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  75

Val Arg Tyr Asp Gly Ser Lys Glu 
1               5               


<210>  76
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  76

Ala Lys Asp Glu Met Ala Arg Trp Ala Tyr Val Asp Trp Leu Pro His 
1               5                   10                  15      


Leu His His Ser Tyr Gly Met Asp Val 
            20                  25  


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  77

Gly Phe Ser Phe Ser Asp Phe Gly 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  78

Val Arg Tyr Asp Gly Ser Lys Glu 
1               5               


<210>  79
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  79

Ala Lys Asp Glu Met Ala Arg Trp Ala Tyr Val Asp Trp Leu Pro His 
1               5                   10                  15      


Leu His His Ser Tyr Gly Met Asp Val 
            20                  25  


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  80

Gly Phe Thr Phe Ser Asn His Trp 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  81

Ile Lys Arg Asp Ala Thr Ser Thr 
1               5               


<210>  82
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  82

Val Arg Glu Gly Gly Tyr Thr Tyr Gly Gly Val Tyr Tyr Tyr Asn Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  83

Asp Phe Ile Phe Asn Asn Tyr Asn 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  84

Ile Asp Thr Ser Thr Tyr Thr Thr 
1               5               


<210>  85
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  85

Ala Arg Asp Arg Tyr Gly Ser Ser Tyr Trp Gly Gly His Tyr Phe His 
1               5                   10                  15      


Ala Met Asp Val 
            20  


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  86

Gly Phe Thr Phe Ser Ser Tyr Asp 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  87

Ile Ser Gly Ser Gly Gly Ser Pro 
1               5               


<210>  88
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  88

Ala Lys Pro Tyr Thr Ser Gly Trp Tyr Val Gly Cys Asp Ser 
1               5                   10                  


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  89

Gly Phe Thr Phe Ser Asp Cys Ala 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  90

Ile Ser Gly Ser Gly Leu Ser Thr 
1               5               


<210>  91
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  91

Thr Lys Ala Pro Trp Asp Tyr Tyr Gly Ser Gly Asn Thr Asp His Phe 
1               5                   10                  15      


Asp His 
        


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  92

Gly Phe Thr Phe Ser Ser His Ala 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  93

Ile Ser Gly Arg Gly Ser Ser Ile 
1               5               


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  94

Ala Lys Gly Leu Ala Asp Phe Asp Tyr 
1               5                   


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  95

Gly Tyr Asp Phe Ala Asn Phe Trp 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  96

Ile Tyr Pro Asp Asp Ser Asp Val 
1               5               


<210>  97
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  97

Thr Arg Arg Tyr Ser Gly Ala Gln Leu Gly Val Asp Ser 
1               5                   10              


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  98

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  99

Ile Ser Val Tyr Asn Gly Asn Thr 
1               5               


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  100

Ala Arg Asp Gly Leu Arg Trp Leu Arg Pro Thr Gly Met Asp Val 
1               5                   10                  15  


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  101

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  102

Ile Ser Ser Ser Gly Thr Asn Thr 
1               5               


<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  103

Val Lys Gly Ser Gly Val Gly Tyr Gln Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  104

Gly Tyr Ser Leu Ser Asp Tyr Ser 
1               5               


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  105

Ile Asn Pro Lys Thr Gly Gly Thr 
1               5               


<210>  106
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  106

Ala Arg Pro Gly Phe Cys Thr Ile Asp Asn Cys His Asp Phe Phe Asp 
1               5                   10                  15      


Ser 
    


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  107

Gly Tyr Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  108

Ile Asn Pro Lys Thr Gly Gly Thr 
1               5               


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  109

Ala Arg Arg Ser Leu Asn Leu Tyr Tyr Asp Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  110

Gly Ala Leu Val Thr Asn Thr Ala Tyr Tyr 
1               5                   10  


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  111

Ile Tyr Ala Asn Gly Arg Thr 
1               5           


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  112

Val Arg Leu Val Pro Lys Arg Thr Ala Thr Leu His Tyr Tyr Ile Asp 
1               5                   10                  15      


Val 
    


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  113

Gly Asp Thr Ser Ser Ile Tyr Ala 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  114

Ile Asn Pro Ile Pro Arg Ile Thr 
1               5               


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  115

Ala Arg Asp Cys Ser Gly Gly Ser Cys Phe Arg Gln Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  116

Gly Asp Thr Ser Ser Ile Tyr Ala 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  117

Ile Asn Pro Ile Pro Arg Ile Thr 
1               5               


<210>  118
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  118

Ala Arg Asp Cys Ser Gly Gly Ser Cys Phe Arg Gln Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  119

Gly Tyr Thr Leu Thr Ser Tyr Asp 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  120

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  121

Ala Arg Gly Arg Ser Ile Ile Asn His Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15  


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  122

Asp Phe Ile Phe Asn Asn Tyr Asn 
1               5               


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  123

Ile Asp Thr Ser Thr Tyr Thr Thr 
1               5               


<210>  124
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  124

Ala Arg Asp Arg Tyr Gly Ser Ser Tyr Trp Gly Gly His Tyr Phe His 
1               5                   10                  15      


Ala Met Asp Val 
            20  


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  125

Gly Phe Ser Phe Ser Ser Tyr Asn 
1               5               


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  126

Ile Ser Ser Gly Ser Ser Tyr Ile 
1               5               


<210>  127
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  127

Thr Arg Asp Arg Tyr Tyr His Asp Ser Asp Glu Tyr Tyr Asp Ala Asp 
1               5                   10                  15      


Gly Phe Asp Val 
            20  


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  128

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  129

Ile Ser Ala Asn Gly Gly Thr Thr 
1               5               


<210>  130
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  130

Ala Arg Asp His Leu Trp Phe Gly Glu Tyr Ile Phe Asp Cys 
1               5                   10                  


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  131

Gly Phe Thr Phe Thr Asp Ala Trp 
1               5               


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  132

Ile Lys Ser Arg Thr Gly Gly Gly Thr Thr 
1               5                   10  


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  133

Val Trp Ser Gly Arg Asn Trp Phe Gly His 
1               5                   10  


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  134

Gly Tyr Thr Leu Thr Ser Tyr Asp 
1               5               


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  135

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  136

Ala Arg Gly Arg Ser Ile Ile Asn His Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15  


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  137

Asp Phe Ile Phe Asn Asn Tyr Asn 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  138

Ile Asp Thr Ser Thr Tyr Thr Thr 
1               5               


<210>  139
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  139

Ala Arg Asp Arg Tyr Gly Ser Ser Tyr Trp Gly Ala Thr Ile Ser Thr 
1               5                   10                  15      


Leu Trp Thr 
            


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  140

Gly Tyr Ile Phe Thr Asp Tyr Trp 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  141

Ile Tyr Pro Gly Asp Ser Glu Thr 
1               5               


<210>  142
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  142

Ala Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr 
1               5                   10                  15      


Leu Ile Asp Asn 
            20  


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  143

Gly Tyr Ile Phe Thr Asp Tyr Trp 
1               5               


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  144

Ile Tyr Pro Gly Asp Ser Glu Thr 
1               5               


<210>  145
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  145

Ala Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr 
1               5                   10                  15      


Leu Ile Asp Asn 
            20  


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  146

Gly Tyr Thr Leu Thr Ser Tyr Asp 
1               5               


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  147

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  148
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  148

Ala Arg Gly Arg Ser Ile Ile Asn His Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15  


<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  149

Gly Tyr Ile Phe Thr Asp Tyr Trp 
1               5               


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  150

Ile Tyr Pro Gly Asp Ser Glu Thr 
1               5               


<210>  151
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  151

Ala Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr 
1               5                   10                  15      


Leu Ile Asp Asn 
            20  


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  152

Gly Tyr Ile Phe Thr Asp Tyr Trp 
1               5               


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  153

Ile Tyr Pro Gly Asp Ser Glu Thr 
1               5               


<210>  154
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  154

Ala Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr 
1               5                   10                  15      


Leu Ile Asp Asn 
            20  


<210>  155
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  155

Gly Tyr Ile Phe Thr Asp Tyr Trp 
1               5               


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  156

Ile Tyr Pro Gly Asp Ser Glu Thr 
1               5               


<210>  157
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies heavy chain

<400>  157

Ala Arg His Gly Arg Gly Tyr Cys Gly Gly Gly Ser Cys Gln Gly Thr 
1               5                   10                  15      


Leu Ile Asp Asn 
            20  


<210>  158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  158

Gln Ser Val Gly Thr Ser 
1               5       


<210>  159
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  159

Asp Ala Ser 
1           


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  160

Gln Gln Arg Ser Asn Gly Pro Pro Ser Trp Thr 
1               5                   10      


<210>  161
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  161

Gln Ser Val Ser Ser Asn 
1               5       


<210>  162
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  162

Gly Ala Ser 
1           


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  163

Gln Gln Tyr Asn Asn Trp Pro Tyr Thr 
1               5                   


<210>  164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  164

Gln Ser Val Ser Ser Asn 
1               5       


<210>  165
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  165

Gly Ala Ser 
1           


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  166

Gln Gln Tyr Asn Asn Trp Pro Tyr Thr 
1               5                   


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  167

Gln Ser Val Phe Ser Ser Ser Tyr Ser Glu Asp Tyr 
1               5                   10          


<210>  168
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  168

Trp Ala Ser 
1           


<210>  169
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  169

Gln Tyr Tyr Ile Thr Pro Ile Thr 
1               5               


<210>  170
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  170

Gln Ser Val Gly Thr Ser 
1               5       


<210>  171
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  171

Asp Ala Ser 
1           


<210>  172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  172

Gln Gln Arg Ser Thr Gly Leu Arg Val Gly Arg 
1               5                   10      


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  173

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  174
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  174

Gly Ala Ser 
1           


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  175

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  176

Gln Ser Val Arg Ser Tyr 
1               5       


<210>  177
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  177

Asp Ala Thr 
1           


<210>  178
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  178

Gln Gln Arg Asn Asn Trp Pro Leu Thr 
1               5                   


<210>  179
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  179

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  180
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  180

Asp Ala Ser 
1           


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  181

Gln Gln Arg Ser Asn Trp Pro Pro Tyr Ser 
1               5                   10  


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  182

Gln Arg Val Asn Thr Gly Tyr 
1               5           


<210>  183
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  183

Gly Ala Ser 
1           


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  184

Gln Gln His Gly Thr Ser Pro Tyr Thr 
1               5                   


<210>  185
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  185

Gln Asp Ile Thr His Ser 
1               5       


<210>  186
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  186

Asp Ala Ser 
1           


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  187

Gln Gln Tyr Asp Asn Val Pro Ile Thr 
1               5                   


<210>  188
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  188

Gln Asn Val Leu Tyr Asn Ser Asn Lys Lys Asn Tyr 
1               5                   10          


<210>  189
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  189

Trp Ala Ser 
1           


<210>  190
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  190

Gln Gln Tyr Tyr Gly Thr Pro Leu Thr 
1               5                   


<210>  191
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  191

Gln Arg Leu Val Tyr Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  192
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  192

Lys Val Ser 
1           


<210>  193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  193

Met Gln Ser Ser Thr Asp Trp Pro Trp Thr 
1               5                   10  


<210>  194
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  194

Arg Ser Val Leu Tyr Thr Ser Thr Asn Arg Tyr Leu 
1               5                   10          


<210>  195
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  195

Trp Ala Ser 
1           


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  196

Gln Gln Tyr Tyr Asn Pro Pro Val Tyr Thr 
1               5                   10  


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  197

Ser Gly His Ser Ser Tyr Ala Ile 
1               5               


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  198

Leu Asn Ser Asp Gly Ser His 
1               5           


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  199

Gln Thr Trp Gly Thr Gly Ile His Trp Val 
1               5                   10  


<210>  200
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  200

Gln Ser Val Ser Asp Tyr 
1               5       


<210>  201
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  201

Ala Ala Ser 
1           


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  202

Xaa Gln Ser Tyr Thr Thr Ala Tyr Thr 
1               5                   


<210>  203
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  203

Gln Ser Val Ser Asp Tyr 
1               5       


<210>  204
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  204

Ala Ala Ser 
1           


<210>  205
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  205

Gln Gln Ser Tyr Thr Thr Ala Tyr Thr 
1               5                   


<210>  206
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  206

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  207
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  207

Asp Ala Ser 
1           


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  208

Gln Gln Arg Ser Asn Trp Pro Trp Thr 
1               5                   


<210>  209
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  209

Gln Ser Val Gly Thr Ser 
1               5       


<210>  210
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  210

Asp Ala Ser 
1           


<210>  211
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  211

Gln Gln Arg Ser Asn Gly Pro Pro Ser Trp Thr 
1               5                   10      


<210>  212
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  212

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  213
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  213

Ala Ala Ser 
1           


<210>  214
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  214

Gln Gln Ser Tyr Ser Thr Leu Ser Leu 
1               5                   


<210>  215
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  215

Gln Ser Val Phe Ser Ser Ser Tyr Ser Glu Asp Tyr 
1               5                   10          


<210>  216
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  216

Trp Ala Ser 
1           


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  217

Gln Gln Tyr Tyr Ile Thr Pro Ile Thr 
1               5                   


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  218

Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  219
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  219

Lys Ile Ser 
1           


<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  220

Cys Lys Leu His Asn Phe Leu Thr Leu 
1               5                   


<210>  221
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  221

Gln Ser Ile Ser Asn Tyr 
1               5       


<210>  222
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  222

Ala Ala Ser 
1           


<210>  223
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  223

Gln Gln Ser Tyr Ser Thr Pro Glu Thr 
1               5                   


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  224

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  225
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  225

Ala Ala Ser 
1           


<210>  226
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  226

Gln Gln Ser Tyr Ser Thr Pro Cys Thr 
1               5                   


<210>  227
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  227

Gln Ser Val Phe Ser Ser Ser Tyr Ser Glu Asp Tyr 
1               5                   10          


<210>  228
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  228

Trp Ala Ser 
1           


<210>  229
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  229

Gln Gln Tyr Tyr Ile Thr Pro Ile Thr 
1               5                   


<210>  230
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  230

Ser Leu Arg Thr Tyr Tyr 
1               5       


<210>  231
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  231

Ala Lys Thr 
1           


<210>  232
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  232

Asn Ser Arg Asp Ser Ser Asp Asn Leu Val Val 
1               5                   10      


<210>  233
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  233

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  234
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  234

Asp Ala Ser 
1           


<210>  235
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  235

Gln Gln Tyr Asp Asn Leu Pro Pro Gly Ser Pro 
1               5                   10      


<210>  236
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  236

Ser Leu Arg Thr Tyr Tyr 
1               5       


<210>  237
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  237

Ala Lys Asn 
1           


<210>  238
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  238

Asn Ser Arg Asp Ser Ser Asp Asn Leu Val Val 
1               5                   10      


<210>  239
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  239

Ser Leu Arg Thr Tyr Tyr 
1               5       


<210>  240
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  240

Ala Lys Thr 
1           


<210>  241
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  241

Asn Ser Arg Asp Ser Ser Asp Asn Leu Val Val 
1               5                   10      


<210>  242
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  242

Ser Leu Arg Thr Tyr Tyr 
1               5       


<210>  243
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  243

Ala Lys Asn 
1           


<210>  244
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toso antibodies light chain

<400>  244

Asn Ser Arg Asp Ser Ser Asp Asn Leu Val Val 
1               5                   10      


