                         SEQUENCE LISTING

<110>  ImmunoQure AG
 
<120>  Human anti-IL-32 antibodies

<130>  IM11A07/P-WO

<150>  EP 13174937.6
<151>  2013-07-03

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(354)
<223>  2C2-VH variable heavy chain (VH) sequence; 2C2: IgG3, lambda

<220>
<221>  V_region
<222>  (91)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(321)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  1
cag ctg cgg gtg cag gag tcg ggc cca gga ctg ttg aag cct gcg gag         48
Gln Leu Arg Val Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ala Glu           
1               5                   10                  15                

acg ctg tcc ctc acc tgc agt gtc tct agt ggc tcc gtc agc aat agt         96
Thr Leu Ser Leu Thr Cys Ser Val Ser Ser Gly Ser Val Ser Asn Ser           
            20                  25                  30                    

cgt tat tac tgg gcc tgg atc cgc cag tcc cca ggg aag gga ctg gag        144
Arg Tyr Tyr Trp Ala Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg agt atg tat tat cgt ggg agg tcc tac tac aac ccg tcc        192
Trp Ile Gly Ser Met Tyr Tyr Arg Gly Arg Ser Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cgc ctc acc att tcg att gac acg tcc aag aat cag ttc        240
Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aaa ctg acc tct ctg acc gcc gca gac acg gcc gtc tat tat        288
Ser Leu Lys Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcc gca gca gtt tat cac gac ctt gac tac tgg ggc cag gga acc        336
Cys Ala Ala Ala Val Tyr His Asp Leu Asp Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc acc gtc tcc tca                                                354
Leu Val Thr Val Ser Ser                                                   
        115                                                               


<210>  2
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Leu Arg Val Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ala Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Ser Gly Ser Val Ser Asn Ser 
            20                  25                  30          


Arg Tyr Tyr Trp Ala Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met Tyr Tyr Arg Gly Arg Ser Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ala Val Tyr His Asp Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  3
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  2C2-VL variable light chain (VL) sequence, lambda type

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(303)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  3
cag tct gtg ttg acg cag ccg ccc tca gtg tct gcg gcc cca gga cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln           
1               5                   10                  15                

aag gtc acc atc tcc tgc tct gga agc ggc tcc agc att ggg aac aat         96
Lys Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Ser Ile Gly Asn Asn           
            20                  25                  30                    

tat gtc tcc tgg tac cag caa ctc cca gga gca gcc ccc aaa ctc ctc        144
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu           
        35                  40                  45                        

att tat gac aat act aag cga ccc tca ggg att cct gac cga ttc tct        192
Ile Tyr Asp Asn Thr Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acg tca gcc acc ctg gcc atc acc gga ctc caa        240
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln           
65                  70                  75                  80            

cct ggg gac gcg gcc gat tat tac tgc gga aca tgg gat agt agt ttc        288
Pro Gly Asp Ala Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Phe           
                85                  90                  95                

agt gtt ttt tgg gta ttc ggc gga ggg acc aag ctg acc gtc cta            333
Ser Val Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu               
            100                 105                 110                   


<210>  4
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Ser Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Thr Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Pro Gly Asp Ala Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Phe 
                85                  90                  95      


Ser Val Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  5
<211>  1134
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1134)
<223>  2C2-CH constant heavy chain (CH) sequence

<400>  5
gct tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac acc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ctc aaa acc cca ctt ggt gac aca act cac aca tgc cca        336
Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro           
            100                 105                 110                   

cgg tgc cca gag ccc aaa tct tgt gac aca cct ccc ccg tgc cca cgg        384
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg           
        115                 120                 125                       

tgc cca gag ccc aaa tct tgt gac aca cct ccc cca tgc cca cgg tgc        432
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys           
    130                 135                 140                           

cca gag ccc aaa tct tgt gac aca cct ccc ccg tgc cca agg tgc cca        480
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro           
145                 150                 155                 160           

gca cct gaa ctc ctg gga gga ccg tca gtc ttc ctc ttc ccc cca aaa        528
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys           
                165                 170                 175               

ccc aag gat acc ctt atg att tcc cgg acc cct gag gtc acg tgc gtg        576
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val           
            180                 185                 190                   

gtg gtg gac gtg agc cac gaa gac ccc gag gtc cag ttc aag tgg tac        624
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr           
        195                 200                 205                       

gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ctg cgg gag gag        672
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Leu Arg Glu Glu           
    210                 215                 220                           

cag tac aac agc acg ttc cgt gtg gtc agc gtc ctc acc gtc ctg cac        720
Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His           
225                 230                 235                 240           

cag gac tgg ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa        768
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys           
                245                 250                 255               

gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa acc aaa gga cag        816
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln           
            260                 265                 270                   

ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg        864
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met           
        275                 280                 285                       

acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc        912
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro           
    290                 295                 300                           

agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac        960
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn           
305                 310                 315                 320           

tac aac acc acg cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc       1008
Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu           
                325                 330                 335               

tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac atc       1056
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile           
            340                 345                 350                   

ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cgc tac acg cag       1104
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln           
        355                 360                 365                       

aag agc ctc tcc ctg tct ccg ggt aaa tga                               1134
Lys Ser Leu Ser Leu Ser Pro Gly Lys                                       
    370                 375                                               


<210>  6
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Leu Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  7
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  2C2-CL constant lambda chain (CL) sequence

<220>
<221>  misc_feature
<222>  (271)..(321)
<223>  not sequenced but obtained from database

<400>  7
agt cag ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct         48
Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctt caa gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tac ctg agc ctg acg cct gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aaa agc tac agc tgc cag gtc aca cat gaa ggg agc acc gtg        288
Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca tag                            321
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  8
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  9
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)
<223>  14B3-VH variable heavy chain (VH) sequence; 14B3: IgG1, lambda

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(315)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  9
cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gcg tct gga ctc act ttc agg acc tat         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Arg Thr Tyr           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aac ggg ctg gag tgg gtg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Val           
        35                  40                  45                        

gca atc ata tgg cat gat ggt aat aaa aaa tac tat gca gac tcc gta        192
Ala Ile Ile Trp His Asp Gly Asn Lys Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc agg gac aat tcc aag aac agt cta tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctc caa atg aac agc ctg aga gtc gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gaa atg aat ggc atc gac gtc tgg ggc caa ggg acc acg gtc        336
Ala Arg Glu Met Asn Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val           
            100                 105                 110                   

acc gtc tcc tca                                                        348
Thr Val Ser Ser                                                           
        115                                                               


<210>  10
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp His Asp Gly Asn Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Asn Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  14B3-VL variable light chain (VL) sequence, lambda type

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  11
tcc tat gag ctg acc cag cca ccc tcg gtg tca gtg tcc cca gga caa         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc acc tgc tct gga gat gcg ttg cca gaa aca tat gtt         96
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Glu Thr Tyr Val           
            20                  25                  30                    

tat tgg tac cag cag aag tca ggc cag gcc cct gtg aag ctc atc tat        144
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Lys Leu Ile Tyr           
        35                  40                  45                        

gag gac agc gaa cga ccc tcc ggg atc cct gag aga ttc tct ggc tcc        192
Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

agc tca ggg aca ttg gcc acc ttg act atc agt ggg gcc cat gtg gag        240
Ser Ser Gly Thr Leu Ala Thr Leu Thr Ile Ser Gly Ala His Val Glu           
65                  70                  75                  80            

gat gaa gct gac tac tac tgt tac tca aca gac agt agt ggt atc ggg        288
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Ile Gly           
                85                  90                  95                

gtg ttc gga gga ggg acc aag ctg acc gtc cta                            321
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                               
            100                 105                                       


<210>  12
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Glu Thr Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Lys Leu Ile Tyr 
        35                  40                  45              


Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Leu Ala Thr Leu Thr Ile Ser Gly Ala His Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Ile Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  13
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  14B3-CH constant heavy chain (CH) sequence

<400>  13
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tcc ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  14
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  14B3-CL constant lambda chain (CL) sequence

<220>
<221>  misc_feature
<222>  (271)..(321)
<223>  not sequenced but obtained from database

<400>  15
agt cag ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct         48
Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctt caa gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tac ctg agc ctg acg cct gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aaa agc tac agc tgc cag gtc aca cat gaa ggg agc acc gtg        288
Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca tag                            321
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  16
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  17
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)
<223>  19A1-VH variable heavy chain (VH) sequence; 19A1: IgG1, lambda

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(315)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  17
cag gtg cac ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg         48
Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gtc gcg tct gga ctc act ttc agg acc tat         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Arg Thr Tyr           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aac ggg ctg gag tgg gtg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Val           
        35                  40                  45                        

gca att ata tgg cat gat ggt aat aaa aaa tac tat gca gac tcc gta        192
Ala Ile Ile Trp His Asp Gly Asn Lys Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc agg gac aat tcc aag aac agt cta tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctc caa atg aac agc ctg aga gtc gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gaa atg aat ggc atc gac gtc tgg ggc caa ggg acc acg gtc        336
Ala Arg Glu Met Asn Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val           
            100                 105                 110                   

acc gtc tcc tca                                                        348
Thr Val Ser Ser                                                           
        115                                                               


<210>  18
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp His Asp Gly Asn Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Asn Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  19
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  19A1-VL variable light chain (VL) sequence, lambda type

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  19
tcc tat gag ctg acc cag cca ccc tcg gtg tca gtg tcc cca gga caa         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc acc tgc tct gga gat gcg ttg cca gaa aca tat gtt         96
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Glu Thr Tyr Val           
            20                  25                  30                    

tat tgg tac cag cag aag tca ggc cag gcc cct gtg aag ctc atc tat        144
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Lys Leu Ile Tyr           
        35                  40                  45                        

gag gac agc gaa cga ccc tcc ggg atc cct gag aga ttc tct ggc tcc        192
Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

agc tca ggg aca ttg gcc acc ttg act atc agt ggg gcc cat gtg gag        240
Ser Ser Gly Thr Leu Ala Thr Leu Thr Ile Ser Gly Ala His Val Glu           
65                  70                  75                  80            

gat gaa gct gac tac tac tgt tac tca aca gac agt agt ggt atc ggg        288
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Ile Gly           
                85                  90                  95                

gtg ttc gga gga ggg acc aag ctg acc gtc cta                            321
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                               
            100                 105                                       


<210>  20
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Glu Thr Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Lys Leu Ile Tyr 
        35                  40                  45              


Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Leu Ala Thr Leu Thr Ile Ser Gly Ala His Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Ile Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  21
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  19A1-CH constant heavy chain (CH) sequence

<400>  21
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tcc ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  22
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  23
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  19A1-CL constant lambda chain (CL) sequence

<220>
<221>  misc_feature
<222>  (271)..(321)
<223>  not sequenced but obtained from database

<400>  23
agt cag ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct         48
Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctt caa gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tac ctg agc ctg acg cct gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aaa agc tac agc tgc cag gtc aca cat gaa ggg agc acc gtg        288
Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca tag                            321
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  24
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  25
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)
<223>  26A6-VH variable heavy chain (VH) sequence; 26A6: IgG1, lambda

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(315)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  25
cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gcg tct gga ctc act ttc agg acc tat         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Arg Thr Tyr           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aac ggg ctg gag tgg gtg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Val           
        35                  40                  45                        

gca atc ata tgg cat gat ggt aat aaa aaa tac ttt gct gac tcc gta        192
Ala Ile Ile Trp His Asp Gly Asn Lys Lys Tyr Phe Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc agg gac aat tcc aag aac agt cta tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctc caa atg aac agc ctg aga gtc gag gac acg gct gtt tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gaa atg aat ggc atc gac gtc tgg ggc caa ggg acc acg gtc        336
Ala Arg Glu Met Asn Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val           
            100                 105                 110                   

acc gtc tcc tca                                                        348
Thr Val Ser Ser                                                           
        115                                                               


<210>  26
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp His Asp Gly Asn Lys Lys Tyr Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Asn Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  26A6-VL variable light chain (VL) sequence, lambda type

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  27
tcc tat gag ctg acc cag cca ccc tcg gtg tca gtg tcc cca gga caa         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc acc tgc tct gga gat gcg ttg cca gaa aca tat gtt         96
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Glu Thr Tyr Val           
            20                  25                  30                    

tat tgg tac cag cag aag tca ggc cag gcc cct gtg aag ctc atc tat        144
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Lys Leu Ile Tyr           
        35                  40                  45                        

gag gac agc gaa cga ccc tcc ggg atc cct gag aga ttc tct ggc tcc        192
Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

agc tca ggg aca ttg gcc acc ttg act atc agt ggg gcc cat gtg gag        240
Ser Ser Gly Thr Leu Ala Thr Leu Thr Ile Ser Gly Ala His Val Glu           
65                  70                  75                  80            

gat gaa gct gac tac tac tgt tac tca aca gac agt agt ggt atc ggg        288
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Ile Gly           
                85                  90                  95                

gtg ttc gga gga ggg acc aag gtg acc gtc cta                            321
Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu                               
            100                 105                                       


<210>  28
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Glu Thr Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Lys Leu Ile Tyr 
        35                  40                  45              


Glu Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Leu Ala Thr Leu Thr Ile Ser Gly Ala His Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Ile Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  29
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  26A6-CL constant lambda chain (CL) sequence

<220>
<221>  misc_feature
<222>  (271)..(321)
<223>  not sequenced but obtained from database

<400>  29
agt cag ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct         48
Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctt caa gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tac ctg agc ctg acg cct gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aaa agc tac agc tgc cag gtc aca cat gaa ggg agc acc gtg        288
Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca tag                            321
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  30
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


