                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
       Novo Nordisk A/S, Novo Nordisk A/S
 
<120>  ANTIBODIES THAT BIND UROKINASE PLASMINOGEN ACTIVATOR

<130>  8692

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  411
<212>  PRT
<213>  Human

<400>  1

Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp Cys Leu Asn Gly 
1               5                   10                  15      


Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile His Trp Cys Asn 
            20                  25                  30          


Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile Asp Lys Ser Lys 
        35                  40                  45              


Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly Lys Ala Ser Thr 
    50                  55                  60                  


Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser Ala Thr Val Leu 
65                  70                  75                  80  


Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu Gln Leu Gly Leu 
                85                  90                  95      


Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg Arg Arg Pro Trp 
            100                 105                 110         


Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln Glu Cys Met Val 
        115                 120                 125             


His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro Pro Glu Glu Leu 
    130                 135                 140                 


Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile Ile 
145                 150                 155                 160 


Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile 
                165                 170                 175     


Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser 
            180                 185                 190         


Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile Asp 
        195                 200                 205             


Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu 
    210                 215                 220                 


Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile 
225                 230                 235                 240 


Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile 
                245                 250                 255     


Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser 
            260                 265                 270         


Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro Gln 
        275                 280                 285             


Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr 
    290                 295                 300                 


Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu Ile 
305                 310                 315                 320 


Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val Thr 
                325                 330                 335     


Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser Cys 
            340                 345                 350         


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg Met 
        355                 360                 365             


Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp 
    370                 375                 380                 


Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile Arg 
385                 390                 395                 400 


Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
                405                 410     


<210>  2
<211>  1296
<212>  DNA
<213>  Human

<400>  2
atgagagccc tgctggcgcg cctgcttctc tgcgtcctgg tcgtgagcga ctccaaaggc       60

agcaatgaac ttcatcaagt tccatcgaac tgtgactgtc taaatggagg aacatgtgtg      120

tccaacaagt acttctccaa cattcactgg tgcaactgcc caaagaaatt cggagggcag      180

cactgtgaaa tagataagtc aaaaacctgc tatgagggga atggtcactt ttaccgagga      240

aaggccagca ctgacaccat gggccggccc tgcctgccct ggaactctgc cactgtcctt      300

cagcaaacgt accatgccca cagatctgat gctcttcagc tgggcctggg gaaacataat      360

tactgcagga acccagacaa ccggaggcga ccctggtgct atgtgcaggt gggcctaaag      420

ccgcttgtcc aagagtgcat ggtgcatgac tgcgcagatg gaaaaaagcc ctcctctcct      480

ccagaagaat taaaatttca gtgtggccaa aagactctga ggccccgctt taagattatt      540

gggggagaat tcaccaccat cgagaaccag ccctggtttg cggccatcta caggaggcac      600

cgggggggct ctgtcaccta cgtgtgtgga ggcagcctca tcagcccttg ctgggtgatc      660

agcgccacac actgcttcat tgattaccca aagaaggagg actacatcgt ctacctgggt      720

cgctcaaggc ttaactccaa cacgcaaggg gagatgaagt ttgaggtgga aaacctcatc      780

ctacacaagg actacagcgc tgacacgctt gctcaccaca acgacattgc cttgctgaag      840

atccgttcca aggagggcag gtgtgcgcag ccatcccgga ctatacagac catctgcctg      900

ccctcgatgt ataacgatcc ccagtttggc acaagctgtg agatcactgg ctttggaaaa      960

gagaattcta ccgactatct ctatccggag cagctgaaaa tgactgttgt gaagctgatt     1020

tcccaccggg agtgtcagca gccccactac tacggctctg aagtcaccac caaaatgctg     1080

tgtgctgctg acccacagtg gaaaacagat tcctgccagg gagactcagg gggacccctc     1140

gtctgttccc tccaaggccg catgactttg actggaattg tgagctgggg ccgtggatgt     1200

gccctgaagg acaagccagg cgtctacacg agagtctcac acttcttacc ctggatccgc     1260

agtcacacca aggaagagaa tggcctggcc ctctga                               1296


<210>  3
<211>  411
<212>  PRT
<213>  Monkey

<400>  3

Leu Thr Pro Pro Leu Phe Ser Pro Ala Asp Cys Gly Cys Leu Asn Gly 
1               5                   10                  15      


Gly Thr Cys Met Ser Asn Lys Tyr Phe Ser Ser Ile His Trp Cys Asn 
            20                  25                  30          


Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile Asp Lys Ser Lys 
        35                  40                  45              


Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly Lys Ala Ser Thr 
    50                  55                  60                  


Asp Thr Met Gly Arg Ser Cys Leu Ala Trp Asn Ser Ala Thr Val Leu 
65                  70                  75                  80  


Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu Gln Leu Gly Leu 
                85                  90                  95      


Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg Arg Arg Pro Trp 
            100                 105                 110         


Cys Tyr Val Gln Val Gly Leu Lys Gln Leu Val Gln Glu Cys Met Val 
        115                 120                 125             


Gln Asn Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro Pro Glu Glu Leu 
    130                 135                 140                 


Gln Phe Gln Cys Gly Gln Arg Thr Leu Arg Pro Arg Phe Lys Ile Val 
145                 150                 155                 160 


Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile 
                165                 170                 175     


Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser 
            180                 185                 190         


Leu Ile Ser Pro Cys Trp Val Val Ser Ala Thr His Cys Phe Ile Asn 
        195                 200                 205             


Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu 
    210                 215                 220                 


Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile 
225                 230                 235                 240 


Leu His Glu Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile 
                245                 250                 255     


Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser 
            260                 265                 270         


Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Thr Tyr Asn Asp Pro Pro 
        275                 280                 285             


Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr 
    290                 295                 300                 


Asp Tyr Leu Tyr Pro Glu Arg Leu Lys Met Thr Val Val Lys Leu Val 
305                 310                 315                 320 


Ser His Gln Lys Cys Arg Gln Pro His Tyr Tyr Gly Ser Glu Val Thr 
                325                 330                 335     


Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Glu Thr Asp Ser Cys 
            340                 345                 350         


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Ile Gln Gly His Met 
        355                 360                 365             


Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp 
    370                 375                 380                 


Lys Pro Gly Val Tyr Thr Arg Val Ser Arg Phe Leu Pro Trp Ile His 
385                 390                 395                 400 


Ser His Thr Arg Glu Glu Asn Gly Leu Ala Leu 
                405                 410     


<210>  4
<211>  1296
<212>  DNA
<213>  Monkey

<400>  4
atgagagccc tgctggcaca cctgcttctc tgcgtcctgg tcgtgagcga ctccaaatcg       60

cttaccccac ctttgttctc tccagcagac tgtggctgtc taaatggagg aacatgtatg      120

tccaacaagt acttctccag cattcactgg tgcaactgcc caaagaagtt cggagggcag      180

cactgtgaga tagataagtc aaaaacctgc tatgagggga atggtcactt ttaccgagga      240

aaggccagca ctgacaccat gggccggtcc tgcctggcct ggaactctgc caccgtcctt      300

cagcaaacat accatgccca cagatctgat gctcttcagc tgggcctggg gaagcacaat      360

tactgcagga acccagacaa ccggaggcga ccctggtgct atgtgcaggt cggcctaaag      420

cagcttgtcc aagagtgcat ggtgcaaaac tgtgcagatg gaaaaaagcc ctcctctcct      480

ccagaagaat tacagtttca gtgtggccaa aggactctga ggccccgctt taagattgtt      540

gggggagaat tcaccaccat cgagaaccag ccctggtttg cagccatcta caggaggcac      600

cggggcggct ctgtcaccta cgtgtgtgga ggcagcctca tcagcccttg ctgggtggtc      660

agcgccacac actgcttcat taattaccca aagaaggagg actacatcgt ctacctgggt      720

cgctcaaggc ttaactccaa cacgcaaggg gagatgaagt ttgaggtgga aaacctcatc      780

ctacatgagg actacagcgc tgacacgctt gctcaccaca acgacattgc cttgctgaag      840

atccgttcta aggagggcag gtgtgcgcag ccatcccgga ccatacagac catctgcctg      900

ccctcgacgt ataacgatcc cccttttggc acaagctgtg agatcactgg ctttggaaaa      960

gagaattcta ccgactatct ctatccggag cggctgaaaa tgactgttgt gaagctggtt     1020

tcccaccaga agtgtcggca gccccactac tacggctctg aagtcaccac caaaatgctg     1080

tgtgctgctg acccacagtg ggaaacagat tcctgccagg gagactcagg gggacccctt     1140

gtctgttcca tccaaggcca catgactttg actggaattg tgagctgggg ccgtggatgt     1200

gccctaaagg acaagccagg cgtctacacg agagtctcac gcttcttgcc ctggattcac     1260

agtcacacca gggaagagaa tggcctagcc ctctga                               1296


<210>  5
<211>  122
<212>  PRT
<213>  Mouse

<400>  5

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met Asn Trp Ile Lys Gln Thr Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Pro Thr Tyr Ser Asp Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Phe Asp Asp Tyr Asp Ser Ser Arg Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  113
<212>  PRT
<213>  Mouse

<400>  6

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Gly Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Leu Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Tyr Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ile Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  119
<212>  PRT
<213>  Mouse

<400>  7

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser His Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Arg Asp Gly Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  8
<211>  107
<212>  PRT
<213>  Mouse

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Thr Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Ser His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  9
<211>  5
<212>  PRT
<213>  Mouse

<400>  9

Ser Tyr Thr Met Ser 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Mouse

<400>  10

Thr Ile Ser Gly Gly Gly Ser His Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  10
<212>  PRT
<213>  Mouse

<400>  11

Asp Gly Arg Asp Gly Ser Trp Phe Ala Tyr 
1               5                   10  


<210>  12
<211>  11
<212>  PRT
<213>  Mouse

<400>  12

Arg Thr Ser Gln Ser Ile Gly Asp Tyr Leu His 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Mouse

<400>  13

Tyr Val Ser Gln Ser Ile Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Mouse

<400>  14

Gln Asn Ser His Ser Phe Pro Leu Thr 
1               5                   


<210>  15
<211>  113
<212>  PRT
<213>  Recombinant - Mouse

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  16
<211>  107
<212>  PRT
<213>  Recombinant - Mouse

<400>  16

Asp Val Val Met Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Gln Ala Ser Glu Gly Ile Gly Asn Tyr 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Lys His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  119
<212>  PRT
<213>  Humanized - Human

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Ser His Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Arg Asp Gly Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  107
<212>  PRT
<213>  Humanized - Human

<400>  18

Asp Val Val Met Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Ser His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  443
<212>  PRT
<213>  Mouse

<400>  19

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser His Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Arg Asp Gly Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
    210                 215                 220                 


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
            260                 265                 270         


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
    290                 295                 300                 


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
305                 310                 315                 320 


Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
            340                 345                 350         


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe 
        355                 360                 365             


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
    370                 375                 380                 


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr 
385                 390                 395                 400 


Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
                405                 410                 415     


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
            420                 425                 430         


Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440             


<210>  20
<211>  214
<212>  PRT
<213>  Mouse

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Thr Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Ser His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  21
<211>  446
<212>  PRT
<213>  Humanized - Human

<400>  21

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser His Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Arg Asp Gly Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  22
<211>  214
<212>  PRT
<213>  Humanized - Human

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Arg Thr Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Ser His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  23
<211>  1332
<212>  DNA
<213>  Mouse

<400>  23
gacgtcaagc tggtggaaag cggaggaggc ctggtcaaac ccggaggcag cctgaagctg       60

agctgcgtgg ccagcggctt caccttcagc agctacacaa tgagctgggt gaggcagaca      120

cccgagaaga ggctggagtg ggtggctacc attagcggag gcggcagcca catctactac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acgccaagaa caccctgtac      240

ctgcagatga gcagcctgaa gagcgaggac accgccatct actactgcac cagggacggc      300

agagacggca gctggttcgc ctactgggga cagggaaccc tggtgaccgt gagcgccgcc      360

aaaacgacac ccccatctgt ctatccgcta gcccctggat ctgctgccca aactaactcc      420

atggtgaccc tgggatgcct ggtcaagggc tatttccctg agccagtgac agtgacctgg      480

aactctggat ccctgtccag cggtgtgcac accttcccag ctgtcctgca gtctgacctc      540

tacactctga gcagctcagt gactgtcccc tccagcacct ggcccagcga gaccgtcacc      600

tgcaacgttg cccacccggc cagcagcacc aaggtggaca agaaaattgt gcccagggat      660

tgtggttgta agccttgcat atgtacagtc ccagaagtat catctgtctt catcttcccc      720

ccaaagccca aggatgtgct caccattact ctgactccta aggtcacgtg tgttgtggta      780

gacatcagca aggatgatcc cgaggtccag ttcagctggt ttgtagatga tgtggaggtg      840

cacacagctc agacgcaacc ccgggaggag cagttcaaca gcactttccg ctcagtcagt      900

gaacttccca tcatgcacca ggactggctc aatggcaagg agttcaaatg cagggtcaac      960

agtgcagctt tccctgcccc catcgagaaa accatctcca aaaccaaagg cagaccgaag     1020

gctccacagg tgtacaccat tccacctccc aaggagcaga tggccaagga taaagtcagt     1080

ctgacctgca tgataacaga cttcttccct gaagacatta ctgtggagtg gcagtggaat     1140

gggcagccag cggagaacta caagaacact cagcccatca tggacacaga tggctcttac     1200

ttcgtctaca gcaagctcaa tgtgcagaag agcaactggg aggcaggaaa tactttcacc     1260

tgctctgtgt tacatgaggg cctgcacaac caccatactg agaagagcct ctcccactct     1320

cctggtaaat ga                                                         1332


<210>  24
<211>  645
<212>  DNA
<213>  Mouse

<400>  24
gacatcgtga tgacccagag ccctgctaca ctgagcgtga cccccggaga cagggtgagc       60

ctgagctgca ggacctccca gagcatcggc gactacctgc actggtacca gcagaagagc      120

cacgagagcc ccaggctgct gatcaagtac gtgagccaga gcatcagcgg cattcccagc      180

aggttcagcg gcagcggaag cggaagcgac ttcaccctca gcatcaacag cgtggaaagc      240

gaggacgtgg gcgtgtacta ctgccagaac agccacagct tccccctcac cttcggcagc      300

ggcaccaagc tggagctgaa gaggaccgtg gcggcgccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      645


<210>  25
<211>  1341
<212>  DNA
<213>  Humanized - Human

<400>  25
gacgtgaagc tggtggaaag cggaggcggc ctcgtgaaac ctggcggaag cctgagactg       60

agctgcgctg ccagcggctt caccttcagc agctacacca tgagctgggt gaggcaggct      120

cccggcaaag gactggagtg ggtggccaca attagcggag gcggctccca catctactac      180

gccgacagcg tcaagggcag gttcaccatc agcagggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcac cagggacggc      300

agggacggaa gctggttcgc ctactgggga cagggcaccc tcgtgaccgt gagcagcgct      360

agcaccaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc atgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agttcaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca ggaggggaat     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc     1320

tccctgtctc tgggtaaatg a                                               1341


<210>  26
<211>  645
<212>  DNA
<213>  Humanized - Human

<400>  26
gacatcgtga tgacccagag ccccgccttc ctgagcgtga cacctggaga gaaggtgacc       60

atcagctgca ggaccagcca gagcatcggc gactacctgc actggtacca gcagaagccc      120

gaccagagcc ccaagctgct gatcaagtac gtgagccagt ccatcagcgg catcccttcc      180

agatttagcg gcagcggcag cggaagcgac ttcaccttca ccatcagcag cctggaagcc      240

gaagacgccg ccacctacta ctgccagaac tcccacagct tccccctgac attcggcggc      300

ggcaccaagg tggagatcaa gaggactgtg gcggcgccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggtaccgct agcgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


