                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF DISORDERS RELATED TO 
       CEP290

<130>  UPN-Y6321PCT

<150>  US 61/847016
<151>  2013-07-16

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  7437
<212>  DNA
<213>  Homo sapiens

<400>  1
atgccaccta atataaactg gaaagaaata atgaaagttg acccagatga cctgccccgt       60

caagaagaac tggcagataa tttattgatt tccttatcca aggtggaagt aaatgagcta      120

aaaagtgaaa agcaagaaaa tgtgatacac cttttcagaa ttactcagtc actaatgaag      180

atgaaagctc aagaagtgga gctggctttg gaagaagtag aaaaagctgg agaagaacaa      240

gcaaaatttg aaaatcaatt aaaaactaaa gtaatgaaac tggaaaatga actggagatg      300

gctcagcagt ctgcaggtgg acgagatact cggtttttac gtaatgaaat ttgccaactt      360

gaaaaacaat tagaacaaaa agatagagaa ttggaggaca tggaaaagga gttggagaaa      420

gagaagaaag ttaatgagca attggctctt cgaaatgagg aggcagaaaa tgaaaacagc      480

aaattaagaa gagagaacaa acgtctaaag aaaaagaatg aacaactttg tcaggatatt      540

attgactacc agaaacaaat agattcacag aaagaaacac ttttatcaag aagaggggaa      600

gacagtgact accgatcaca gttgtctaaa aaaaactatg agcttatcca atatcttgat      660

gaaattcaga ctttaacaga agctaatgag aaaattgaag ttcagaatca agaaatgaga      720

aaaaatttag aagagtctgt acaggaaatg gagaagatga ctgatgaata taatagaatg      780

aaagctattg tgcatcagac agataatgta atagatcagt taaaaaaaga aaacgatcat      840

tatcaacttc aagtgcagga gcttacagat cttctgaaat caaaaaatga agaagatgat      900

ccaattatgg tagctgtcaa tgcaaaagta gaagaatgga agctaatttt gtcttctaaa      960

gatgatgaaa ttattgagta tcagcaaatg ttacataacc taagggagaa acttaagaat     1020

gctcagcttg atgctgataa aagtaatgtt atggctctac agcagggtat acaggaacga     1080

gacagtcaaa ttaagatgct caccgaacaa gtagaacaat atacaaaaga aatggaaaag     1140

aatacttgta ttattgaaga tttgaaaaat gagctccaaa gaaacaaagg tgcttcaacc     1200

ctttctcaac agactcatat gaaaattcag tcaacgttag acattttaaa agagaaaact     1260

aaagaggctg agagaacagc tgaactggct gaggctgatg ctagggaaaa ggataaagaa     1320

ttagttgagg ctctgaagag gttaaaagat tatgaatcgg gagtatatgg tttagaagat     1380

gctgtcgttg aaataaagaa ttgtaaaaac caaattaaaa taagagatcg agagattgaa     1440

atattaacaa aggaaatcaa taaacttgaa ttgaagatca gtgatttcct tgatgaaaat     1500

gaggcactta gagagcgtgt gggccttgaa ccaaagacaa tgattgattt aactgaattt     1560

agaaatagca aacacttaaa acagcagcag tacagagctg aaaaccagat tcttttgaaa     1620

gagattgaaa gtctagagga agaacgactt gatctgaaaa aaaaaattcg tcaaatggct     1680

caagaaagag gaaaaagaag tgcaacttca ggattaacca ctgaggacct gaacctaact     1740

gaaaacattt ctcaaggaga tagaataagt gaaagaaaat tggatttatt gagcctcaaa     1800

aatatgagtg aagcacaatc aaagaatgaa tttctttcaa gagaactaat tgaaaaagaa     1860

agagatttag aaaggagtag gacagtgata gccaaatttc agaataaatt aaaagaatta     1920

gttgaagaaa ataagcaact tgaagaaggt atgaaagaaa tattgcaagc aattaaggaa     1980

atgcagaaag atcctgatgt taaaggagga gaaacatctc taattatccc tagccttgaa     2040

agactagtta atgctataga atcaaagaat gcagaaggaa tctttgatgc gagtctgcat     2100

ttgaaagccc aagttgatca gcttaccgga agaaatgaag aattaagaca ggagctcagg     2160

gaatctcgga aagaggctat aaattattca cagcagttgg caaaagctaa tttaaagata     2220

gaccatcttg aaaaagaaac tagtctttta cgacaatcag aaggatcgaa tgttgttttt     2280

aaaggaattg acttacctga tgggatagca ccatctagtg ccagtatcat taattctcag     2340

aatgaatatt taatacattt gttacaggaa ctagaaaata aagaaaaaaa gttaaagaat     2400

ttagaagatt ctcttgaaga ttacaacaga aaatttgctg taattcgtca tcaacaaagt     2460

ttgttgtata aagaatacct aagtgaaaag gagacctgga aaacagaatc taaaacaata     2520

aaagaggaaa agagaaaact tgaggatcaa gtccaacaag atgctataaa agtaaaagaa     2580

tataataatt tgctcaatgc tcttcagatg gattcggatg aaatgaaaaa aatacttgca     2640

gaaaatagta ggaaaattac tgttttgcaa gtgaatgaaa aatcacttat aaggcaatat     2700

acaaccttag tagaattgga gcgacaactt agaaaagaaa atgagaagca aaagaatgaa     2760

ttgttgtcaa tggaggctga agtttgtgaa aaaattgggt gtttgcaaag atttaaggaa     2820

atggccattt tcaagattgc agctctccaa aaagttgtag ataatagtgt ttctttgtct     2880

gaactagaac tggctaataa acagtacaat gaactgactg ctaagtacag ggacatcttg     2940

caaaaagata atatgcttgt tcaaagaaca agtaacttgg aacacctgga gtgtgaaaac     3000

atctccttaa aagaacaagt ggagtctata aataaagaac tggagattac caaggaaaaa     3060

cttcacacta ttgaacaagc ctgggaacag gaaactaaat taggtaatga atctagcatg     3120

gataaggcaa agaaatcaat aaccaacagt gacattgttt ccatttcaaa aaaaataact     3180

atgctggaaa tgaaggaatt aaatgaaagg cagcgggctg aacattgtca aaaaatgtat     3240

gaacacttac ggacttcgtt aaagcaaatg gaggaacgta attttgaatt ggaaaccaaa     3300

tttgctgagc ttaccaaaat caatttggat gcacagaagg tggaacagat gttaagagat     3360

gaattagctg atagtgtgag caaggcagta agtgatgctg ataggcaacg gattctagaa     3420

ttagagaaga atgaaatgga actaaaagtt gaagtgtcaa aactgagaga gatttctgat     3480

attgccagaa gacaagttga aattttgaat gcacaacaac aatctaggga caaggaagta     3540

gagtccctca gaatgcaact gctagactat caggcacagt ctgatgaaaa gtcgctcatt     3600

gccaagttgc accaacataa tgtctctctt caactgagtg aggctactgc tcttggtaag     3660

ttggagtcaa ttacatctaa actgcagaag atggaggcct acaacttgcg cttagagcag     3720

aaacttgatg aaaaagaaca ggctctctat tatgctcgtt tggagggaag aaacagagca     3780

aaacatctgc gccaaacaat tcagtctcta cgacgacagt ttagtggagc tttacccttg     3840

gcacaacagg aaaagttctc caaaacaatg attcaactac aaaatgacaa acttaagata     3900

atgcaagaaa tgaaaaattc tcaacaagaa catagaaata tggagaacaa aacattggag     3960

atggaattaa aattaaaggg cctggaagag ttaataagca ctttaaagga taccaaagga     4020

gcccaaaagg taatcaactg gcatatgaaa atagaagaac ttcgtcttca agaacttaaa     4080

ctaaatcggg aattagtcaa ggataaagaa gaaataaaat atttgaataa cataatttct     4140

gaatatgaac gtacaatcag cagtcttgaa gaagaaattg tgcaacagaa caagtttcat     4200

gaagaaagac aaatggcctg ggatcaaaga gaagttgacc tggaacgcca actagacatt     4260

tttgaccgtc agcaaaatga aatactaaat gcggcacaaa agtttgaaga agctacagga     4320

tcaatccctg accctagttt gccccttcca aatcaacttg agatcgctct aaggaaaatt     4380

aaggagaaca ttcgaataat tctagaaaca cgggcaactt gcaaatcact agaagagaaa     4440

ctaaaagaga aagaatctgc tttaaggtta gcagaacaaa atatactgtc aagagacaaa     4500

gtaatcaatg aactgaggct tcgattgcct gccactgcag aaagagaaaa gctcatagct     4560

gagctaggca gaaaagagat ggaaccaaaa tctcaccaca cattgaaaat tgctcatcaa     4620

accattgcaa acatgcaagc aaggttaaat caaaaagaag aagtattaaa gaagtatcaa     4680

cgtcttctag aaaaagccag agaggagcaa agagaaattg tgaagaaaca tgaggaagac     4740

cttcatattc ttcatcacag attagaacta caggctgata gttcactaaa taaattcaaa     4800

caaacggctt gggatttaat gaaacagtct cccactccag ttcctaccaa caagcatttt     4860

attcgtctgg ctgagatgga acagacagta gcagaacaag atgactctct ttcctcactc     4920

ttggtcaaac taaagaaagt atcacaagat ttggagagac aaagagaaat cactgaatta     4980

aaagtaaaag aatttgaaaa tatcaaatta cagcttcaag aaaaccatga agatgaagtg     5040

aaaaaagtaa aagcggaagt agaggattta aagtatcttc tggaccagtc acaaaaggag     5100

tcacagtgtt taaaatctga acttcaggct caaaaagaag caaattcaag agctccaaca     5160

actacaatga gaaatctagt agaacggcta aagagccaat tagccttgaa ggagaaacaa     5220

cagaaagcac ttagtcgggc acttttagaa ctccgggcag aaatgacagc agctgctgaa     5280

gaacgtatta tttctgcaac ttctcaaaaa gaggcccatc tcaatgttca acaaatcgtt     5340

gatcgacata ctagagagct aaagacacaa gttgaagatt taaatgaaaa tcttttaaaa     5400

ttgaaagaag cacttaaaac aagtaaaaac agagaaaact cactaactga taatttgaat     5460

gacttaaata atgaactgca aaagaaacaa aaagcctata ataaaatact tagagagaaa     5520

gaggaaattg atcaagagaa tgatgaactg aaaaggcaaa ttaaaagact aaccagtgga     5580

ttacagggca aacccctgac agataataaa caaagtctaa ttgaagaact ccaaaggaaa     5640

gttaaaaaac tagagaacca attagaggga aaggtggagg aagtagacct aaaacctatg     5700

aaagaaaaga atgctaaaga agaattaatt aggtgggaag aaggtaaaaa gtggcaagcc     5760

aaaatagaag gaattcgaaa caagttaaaa gagaaagagg gggaagtctt tactttaaca     5820

aagcagttga atactttgaa ggatcttttt gccaaagccg ataaagagaa acttactttg     5880

cagaggaaac taaaaacaac tggcatgact gttgatcagg ttttgggaat acgagctttg     5940

gagtcagaaa aagaattgga agaattaaaa aagagaaatc ttgacttaga aaatgatata     6000

ttgtatatga gggcccacca agctcttcct cgagattctg ttgtagaaga tttacattta     6060

caaaatagat acctccaaga aaaacttcat gctttagaaa aacagttttc aaaggataca     6120

tattctaagc cttcaatttc aggaatagag tcagatgatc attgtcagag agaacaggag     6180

cttcagaagg aaaacttgaa gttgtcatct gaaaatattg aactgaaatt tcagcttgaa     6240

caagcaaata aagatttgcc aagattaaag aatcaagtca gagatttgaa ggaaatgtgt     6300

gaatttctta agaaagaaaa agcagaagtt cagcggaaac ttggccatgt tagagggtct     6360

ggtagaagtg gaaagacaat cccagaactg gaaaaaacca ttggtttaat gaaaaaagta     6420

gttgaaaaag tccagagaga aaatgaacag ttgaaaaaag catcaggaat attgactagt     6480

gaaaaaatgg ctaatattga gcaggaaaat gaaaaattga aggctgaatt agaaaaactt     6540

aaagctcatc ttgggcatca gttgagcatg cactatgaat ccaagaccaa aggcacagaa     6600

aaaattattg ctgaaaatga aaggcttcgt aaagaactta aaaaagaaac tgatgctgca     6660

gagaaattac ggatagcaaa gaataattta gagatattaa atgagaagat gacagttcaa     6720

ctagaagaga ctggtaagag attgcagttt gcagaaagca gaggtccaca gcttgaaggt     6780

gctgacagta agagctggaa atccattgtg gttacaagaa tgtatgaaac caagttaaaa     6840

gaattggaaa ctgatattgc caaaaaaaat caaagcatta ctgaccttaa acagcttgta     6900

aaagaagcaa cagagagaga acaaaaagtt aacaaataca atgaagacct tgaacaacag     6960

attaagattc ttaaacatgt tcctgaaggt gctgagacag agcaaggcct taaacgggag     7020

cttcaagttc ttagattagc taatcatcag ctggataaag agaaagcaga attaatccat     7080

cagatagaag ctaacaagga ccaaagtgga gctgaaagca ccatacctga tgctgatcaa     7140

ctaaaggaaa aaataaaaga tctagagaca cagctcaaaa tgtcagatct agaaaagcag     7200

catttgaagg aggaaataaa gaagctgaaa aaagaactgg aaaattttga tccttcattt     7260

tttgaagaaa ttgaagatct taagtataat tacaaggaag aagtgaagaa gaatattctc     7320

ttagaagaga aggtaaaaaa actttcagaa caattgggag ttgaattaac tagccctgtt     7380

gctgcttctg aagagtttga agatgaagaa gaaagtcctg ttaatttccc catttac        7437


<210>  2
<211>  2479
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Ile Ser Gly Ile Glu  Ser Asp Asp His Cys  Gln Arg Glu 
    2045                 2050                 2055             


Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu Ser Ser  Glu Asn Ile 
    2060                 2065                 2070             


Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn Lys Asp  Leu Pro Arg 
    2075                 2080                 2085             


Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu Met Cys  Glu Phe Leu 
    2090                 2095                 2100             


Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys Leu Gly  His Val Arg 
    2105                 2110                 2115             


Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro Glu Leu  Glu Lys Thr 
    2120                 2125                 2130             


Ile Gly  Leu Met Lys Lys Val  Val Glu Lys Val Gln  Arg Glu Asn 
    2135                 2140                 2145             


Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu Thr Ser  Glu Lys Met 
    2150                 2155                 2160             


Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu Lys Ala  Glu Leu Glu 
    2165                 2170                 2175             


Lys Leu  Lys Ala His Leu Gly  His Gln Leu Ser Met  His Tyr Glu 
    2180                 2185                 2190             


Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg 
    2195                 2200                 2205             


Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu 
    2210                 2215                 2220             


Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr 
    2225                 2230                 2235             


Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser 
    2240                 2245                 2250             


Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser 
    2255                 2260                 2265             


Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu 
    2270                 2275                 2280             


Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln 
    2285                 2290                 2295             


Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr 
    2300                 2305                 2310             


Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile Leu Lys  His Val Pro 
    2315                 2320                 2325             


Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val 
    2330                 2335                 2340             


Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu 
    2345                 2350                 2355             


Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser 
    2360                 2365                 2370             


Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu 
    2375                 2380                 2385             


Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu Lys Gln  His Leu Lys 
    2390                 2395                 2400             


Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro 
    2405                 2410                 2415             


Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu 
    2420                 2425                 2430             


Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu 
    2435                 2440                 2445             


Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser 
    2450                 2455                 2460             


Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile 
    2465                 2470                 2475             


Tyr 
    


<210>  3
<211>  7437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct having codon optimization of human nucleic 
       acid sequence for CEP290

<400>  3
atgcccccaa acatcaattg gaaagagatt atgaaggtag accccgatga tcttcctaga       60

caggaagagc ttgctgataa tcttttgatc tccctcagta aggtggaggt gaacgagctg      120

aaatcagaaa agcaggagaa tgttatacat ctttttcgca tcacccagtc tctcatgaag      180

atgaaagcac aagaagtgga actcgcattg gaagaggttg agaaagcggg cgaggagcag      240

gctaagtttg aaaaccagct gaaaacgaag gttatgaagc tggagaacga gctcgagatg      300

gcgcagcagt cagccggagg tagggataca aggtttttga gaaatgagat atgtcagttg      360

gagaaacagc ttgagcagaa agatcgggag ttggaggaca tggaaaagga gctcgaaaaa      420

gaaaagaaag tgaatgagca gctcgccctg cggaacgaag aagccgaaaa cgaaaacagt      480

aagctgagaa gggaaaacaa acggctgaaa aagaagaacg agcagctctg tcaggatatc      540

atagattacc agaaacagat cgattcacaa aaagaaactt tgctctcacg aaggggagaa      600

gatagcgact atagatcaca gctcagtaag aagaactacg agctgattca gtacttggat      660

gaaattcaga ccctgacaga agccaatgag aaaatcgaag tacagaacca agaaatgcgg      720

aaaaacctcg aggagagcgt gcaagagatg gagaagatga ccgacgaata caaccggatg      780

aaagctattg tacatcagac tgacaacgtc atcgatcaat tgaagaaaga aaacgaccac      840

taccaattgc aagttcaaga gctgaccgat ctcctcaaat ccaaaaacga ggaggacgac      900

cccataatgg tggccgtgaa cgctaaagtc gaagagtgga aactgatcct ctcctccaag      960

gatgacgaga ttatcgaata tcagcagatg ctgcacaatc tgcgcgagaa gttgaagaat     1020

gcacagctcg acgccgacaa atctaatgta atggccctgc agcagggaat ccaagaaagg     1080

gatagtcaaa tcaaaatgct tactgagcaa gtcgaacagt acaccaaaga gatggagaaa     1140

aacacttgca tcattgagga cctcaagaac gaattgcagc gaaacaaggg ggcttctaca     1200

ctcagtcagc aaactcatat gaaaatccag agcactctgg acatcctcaa ggagaaaaca     1260

aaggaagccg agcgcacagc cgaactggca gaagccgatg cacgcgagaa ggacaaagag     1320

cttgtggagg ctcttaagcg gctcaaggac tacgaatccg gggtttacgg actcgaggac     1380

gccgtcgtgg aaatcaagaa ctgcaagaac cagattaaga ttcgggacag agagatcgaa     1440

atcctgacca aggaaatcaa taagctggaa ctcaagatta gtgatttcct cgatgagaac     1500

gaagccctgc gggaacgcgt aggactggaa cccaaaacaa tgatcgatct gaccgaattc     1560

cgcaattcta agcaccttaa acagcagcag taccgagcgg agaaccagat tctgctgaaa     1620

gaaattgagt cacttgagga ggagagactt gatcttaaga agaagattag gcaaatggct     1680

caagaacggg gaaaacggtc cgcaacgagt ggcctgacta ccgaggatct gaatcttacg     1740

gagaacataa gccaaggcga caggatttca gaacggaaat tggatttgct tagcctcaag     1800

aatatgagtg aagcccagag caagaatgag tttctgtcca gggaactgat tgaaaaagag     1860

cgggaccttg aacggagcag aacagtcatc gccaagttcc agaacaaact gaaagagctg     1920

gtggaggaaa acaagcagct ggaggaaggc atgaaggaaa ttctccaggc aatcaaggag     1980

atgcaaaagg acccagatgt caaaggcgga gaaacgtccc tgattatccc ctcactcgag     2040

cggctggtga atgccattga atctaagaac gcagagggta tctttgacgc ttcactgcac     2100

cttaaggccc aagtcgatca gctgacaggc agaaatgagg agcttcgcca ggaactccgc     2160

gagtcccgca aagaagcaat caactatagt cagcagctgg caaaagctaa cctcaaaatc     2220

gaccatctcg aaaaagaaac gtccctgctc agacagtccg agggcagcaa tgttgtgttc     2280

aagggcatag atctcccgga cggcattgcc cccagtagtg cttccatcat aaactcccaa     2340

aacgaatact tgatccatct gctgcaagag cttgagaaca aggagaagaa acttaagaat     2400

ttggaggaca gcctcgagga ctacaatagg aagttcgctg tcatccggca ccagcagagc     2460

ttgttgtata aggaatatct tagtgagaag gagacttgga aaacagagag taaaacgata     2520

aaggaagaga agcgcaaact ggaggaccag gttcagcagg atgccattaa ggtgaaagag     2580

tacaataacc ttctgaatgc gttgcagatg gacagcgacg agatgaagaa aatcttggct     2640

gagaattccc ggaaaatcac cgtgctccaa gtcaatgaga agtccctcat aagacagtac     2700

accacactcg tcgaactgga aagacagctg aggaaggaga acgaaaaaca gaaaaacgag     2760

ctgcttagca tggaggccga agtatgcgag aagataggat gtctgcaaag gttcaaagag     2820

atggccatat tcaagatcgc ggcactccag aaagtggtcg ataactctgt gtctctcagc     2880

gagttggaac tggccaataa gcagtacaat gagctgacag ccaagtatag agatattctc     2940

caaaaggaca atatgttggt ccagaggact tcaaatcttg agcacttgga gtgtgagaac     3000

atttcactta aagaacaagt agagtccatc aataaggagc tggaaatcac aaaagaaaaa     3060

ctgcacacaa tagaacaagc atgggaacag gaaactaaac tgggcaacga aagcagcatg     3120

gacaaggcca agaaatcaat cactaacagc gacattgtga gtatttctaa gaagatcact     3180

atgctggaga tgaaagagtt gaacgagagg cagagagccg agcactgtca gaagatgtat     3240

gaacacctta gaacatccct caaacagatg gaggaaagaa acttcgagct ggaaaccaag     3300

tttgctgagc tgaccaagat taaccttgac gcccagaagg tggagcagat gctgcgcgat     3360

gaactggccg acagtgtaag caaggcggtc agcgacgcag accgccagcg gattttggag     3420

ctggaaaaga acgaaatgga gctcaaagtc gaggtcagta agcttcgcga aatcagcgat     3480

atcgctaggc ggcaggtgga gattcttaat gcccagcaac agtcccgaga taaagaggtt     3540

gagtcactcc ggatgcaact cctcgattac caggcccaga gcgacgaaaa gtcactcatc     3600

gcaaagttgc accagcacaa cgtttccctt cagctgtccg aagccacagc cttggggaaa     3660

ttggaatcca ttaccagcaa gctgcagaaa atggaggcgt acaatctgcg cctcgagcag     3720

aagctggacg agaaggagca ggccctgtat tacgctcgcc tggaaggacg gaaccgagct     3780

aagcatctgc ggcagactat tcagagcctg cggaggcaat tcagcggagc cctgcctctc     3840

gctcagcaag agaagttttc taaaacaatg atacagctgc aaaatgataa actcaaaatc     3900

atgcaagaga tgaagaactc tcagcaggag cacagaaaca tggagaacaa gacactggag     3960

atggaactca agttgaaagg gctggaggag ttgatttcta cccttaagga tacaaaaggg     4020

gcacaaaagg tcattaactg gcatatgaag atagaggaac tgagactgca agaactcaaa     4080

ctgaatagag agttggtgaa ggacaaagaa gagatcaagt accttaacaa tatcatctca     4140

gaatacgagc ggactatcag ttcactggag gaggagattg ttcagcagaa caaattccat     4200

gaggaaaggc agatggcttg ggatcagaga gaagtggatt tggagaggca gctggacatc     4260

tttgatagac aacagaatga gatcctcaac gcggcacaga aattcgaaga agcgacaggt     4320

tcaatccccg atccatctct tccactccca aatcagcttg agattgctct gagaaagatc     4380

aaggaaaaca tacggattat ccttgagact agagctactt gcaagagcct cgaagaaaaa     4440

ctgaaggaga aggagtctgc actgcggctt gcagagcaga atatcctgtc tcgggataag     4500

gttatcaacg aactgcgcct gaggcttcct gctaccgccg agagagagaa actgattgct     4560

gaacttggac gaaaagaaat ggaaccgaaa tctcatcaca cgctcaagat tgcccaccag     4620

acaatagcca atatgcaggc caggctgaat cagaaagagg aggtgctgaa gaagtatcaa     4680

cgcctgctgg agaaagctag ggaggagcag agagagattg tgaaaaagca cgaagaggac     4740

ctccatatcc tccatcatcg gttggagctt caggcagatt cctccctgaa caagtttaag     4800

cagacagcct gggaccttat gaaacagtct ccaacacccg tgccgactaa caagcatttc     4860

atccgcttgg cggagatgga acagaccgtg gccgagcagg acgactcact gtcctccctt     4920

ctggtaaagc tgaagaaagt aagccaggac cttgagcgac agagggagat taccgagctg     4980

aaggtcaagg aattcgagaa catcaagctg caactccaag agaaccacga agatgaggtc     5040

aagaaggtga aggcagaagt tgaggatttg aagtatctgc tggatcagtc ccagaaggag     5100

tcacagtgct tgaaaagcga actgcaggca cagaaggaag ccaatagccg agcccctacc     5160

acgactatga gaaacttggt ggaacggctc aaatcccagc tcgccttgaa agagaagcag     5220

cagaaagcac tgtcccgagc gttgcttgag ctgcgagctg agatgacggc agcagccgag     5280

gagcgcatca tttctgctac cagccaaaaa gaggcccatc tgaacgttca acagattgtt     5340

gaccgccaca ccagggagct caagacccaa gtagaggacc ttaatgagaa cctgctgaaa     5400

ttgaaagagg cacttaagac ctccaagaac cgggagaact ctctgaccga caatctgaac     5460

gatctgaaca atgagctgca gaagaaacag aaagcctaca ataagatact gcgagaaaaa     5520

gaagaaatag accaggagaa cgatgagctc aaacggcaga tcaaaaggct gacaagcggc     5580

ctgcaaggca aacctctcac cgacaataag cagtccctga tcgaggaact gcagcggaaa     5640

gtgaagaaac tcgaaaacca acttgaaggg aaggtggaag aagttgacct taagcccatg     5700

aaagagaaaa acgcaaagga ggaactcatt agatgggagg agggcaaaaa gtggcaggcc     5760

aaaatcgaag ggataaggaa caaattgaaa gagaaggaag gggaagtgtt tactctgacc     5820

aagcagctca atactctcaa ggaccttttt gctaaagccg acaaagagaa actgaccctg     5880

cagagaaagc tgaaaacaac aggcatgacc gtggaccagg tgttggggat tagggccttg     5940

gagagtgaaa aggagctgga ggagctgaaa aagcgcaatc tggacttgga gaatgatatc     6000

ttgtatatgc gcgctcacca ggctctgccg agggacagcg tggtggagga cctccatttg     6060

caaaatcgat atctccaaga gaagctccat gcgctggaaa aacagttctc taaagatacc     6120

tattccaaac cttctattag cggcattgaa tcagacgatc attgccaaag ggagcaggaa     6180

ctgcagaagg aaaacttgaa gctgagctct gagaacattg agctgaagtt ccagctggag     6240

caagccaata aggatctccc tcggctgaag aaccaggttc gggacttgaa ggagatgtgc     6300

gagtttctca aaaaggaaaa ggcagaggtt cagcgcaagc tcgggcacgt gagaggctct     6360

gggaggagtg gaaaaaccat accagagctt gagaaaacta tcggtttgat gaaaaaggtc     6420

gtggagaaag tccagagaga aaatgagcag ctgaaaaagg ccagtggcat tctgacctca     6480

gagaagatgg caaacatcga acaagagaac gagaagctca aggctgaact ggaaaagctt     6540

aaggctcatc tggggcacca gctgtctatg cactatgaaa gcaagacaaa aggcaccgag     6600

aagataatcg ccgagaatga gcgcctgaga aaagaactga agaaggagac tgatgccgct     6660

gaaaagctga gaatcgcaaa gaataacctt gaaatactga atgagaagat gaccgtgcag     6720

ctcgaggaaa ccggaaagcg actgcagttc gctgaatctc gagggccaca actcgaggga     6780

gcggactcta aaagctggaa gagtatagtc gtcactagga tgtatgaaac caagctgaag     6840

gaactggaaa cggacattgc taagaaaaac cagtccatca cagatctgaa acagttggta     6900

aaagaggcta ctgaaaggga gcagaaagtc aataagtata acgaggacct cgaacagcag     6960

atcaagatac tgaaacacgt gccagaaggg gcggaaacgg agcaaggcct gaaacgagaa     7020

ctgcaagtgc tgcgactggc taatcaccag ctggataagg agaaagcaga gctgatccat     7080

cagatagaag cgaataagga tcaatctggt gcggaatcta ccatacccga cgccgatcag     7140

cttaaggaga agattaagga tctcgaaact cagttgaaga tgagcgactt ggaaaaacag     7200

cacttgaagg aagagattaa gaaactcaag aaggaactcg agaacttcga ccctagtttc     7260

tttgaggaaa tcgaggatct gaaatacaac tataaggagg aagtgaagaa gaatatcttg     7320

ctggaagaaa aggtgaaaaa gctttcagag caactcggcg tggagctgac ctctcccgta     7380

gccgcaagtg aggagtttga ggatgaagaa gaaagccctg ttaacttccc gatctat        7437


<210>  4
<211>  2479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct having codon optimization of human protein 
       sequence for CEP290

<400>  4

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Ile Ser Gly Ile Glu  Ser Asp Asp His Cys  Gln Arg Glu 
    2045                 2050                 2055             


Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu Ser Ser  Glu Asn Ile 
    2060                 2065                 2070             


Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn Lys Asp  Leu Pro Arg 
    2075                 2080                 2085             


Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu Met Cys  Glu Phe Leu 
    2090                 2095                 2100             


Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys Leu Gly  His Val Arg 
    2105                 2110                 2115             


Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro Glu Leu  Glu Lys Thr 
    2120                 2125                 2130             


Ile Gly  Leu Met Lys Lys Val  Val Glu Lys Val Gln  Arg Glu Asn 
    2135                 2140                 2145             


Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu Thr Ser  Glu Lys Met 
    2150                 2155                 2160             


Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu Lys Ala  Glu Leu Glu 
    2165                 2170                 2175             


Lys Leu  Lys Ala His Leu Gly  His Gln Leu Ser Met  His Tyr Glu 
    2180                 2185                 2190             


Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg 
    2195                 2200                 2205             


Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu 
    2210                 2215                 2220             


Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr 
    2225                 2230                 2235             


Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser 
    2240                 2245                 2250             


Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser 
    2255                 2260                 2265             


Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu 
    2270                 2275                 2280             


Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln 
    2285                 2290                 2295             


Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr 
    2300                 2305                 2310             


Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile Leu Lys  His Val Pro 
    2315                 2320                 2325             


Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val 
    2330                 2335                 2340             


Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu 
    2345                 2350                 2355             


Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser 
    2360                 2365                 2370             


Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu 
    2375                 2380                 2385             


Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu Lys Gln  His Leu Lys 
    2390                 2395                 2400             


Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro 
    2405                 2410                 2415             


Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu 
    2420                 2425                 2430             


Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu 
    2435                 2440                 2445             


Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser 
    2450                 2455                 2460             


Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile 
    2465                 2470                 2475             


Tyr 
    


<210>  5
<211>  3705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct; nucleic acid sequence containing codon 
       optimized human CEP290 fragments spliced together in a single 
       open reading frame; the nucleic acid sequences encoding fragments
       aa130-380, aa700-1040; aa1260-1605 and aa1695-1990.

<400>  5
atggagttgg aggacatgga aaaggagctc gaaaaagaaa agaaagtgaa tgagcagctc       60

gccctgcgga acgaagaagc cgaaaacgaa aacagtaagc tgagaaggga aaacaaacgg      120

ctgaaaaaga agaacgagca gctctgtcag gatatcatag attaccagaa acagatcgat      180

tcacaaaaag aaactttgct ctcacgaagg ggagaagata gcgactatag atcacagctc      240

agtaagaaga actacgagct gattcagtac ttggatgaaa ttcagaccct gacagaagcc      300

aatgagaaaa tcgaagtaca gaaccaagaa atgcggaaaa acctcgagga gagcgtgcaa      360

gagatggaga agatgaccga cgaatacaac cggatgaaag ctattgtaca tcagactgac      420

aacgtcatcg atcaattgaa gaaagaaaac gaccactacc aattgcaagt tcaagagctg      480

accgatctcc tcaaatccaa aaacgaggag gacgacccca taatggtggc cgtgaacgct      540

aaagtcgaag agtggaaact gatcctctcc tccaaggatg acgagattat cgaatatcag      600

cagatgctgc acaatctgcg cgagaagttg aagaatgcac agctcgacgc cgacaaatct      660

aatgtaatgg ccctgcagca gggaatccaa gaaagggata gtcaaatcaa aatgcttact      720

gagcaagtcg aacagtacac caaagagatg gagaaacacc ttaaggccca agtcgatcag      780

ctgacaggca gaaatgagga gcttcgccag gaactccgcg agtcccgcaa agaagcaatc      840

aactatagtc agcagctggc aaaagctaac ctcaaaatcg accatctcga aaaagaaacg      900

tccctgctca gacagtccga gggcagcaat gttgtgttca agggcataga tctcccggac      960

ggcattgccc ccagtagtgc ttccatcata aactcccaaa acgaatactt gatccatctg     1020

ctgcaagagc ttgagaacaa ggagaagaaa cttaagaatt tggaggacag cctcgaggac     1080

tacaatagga agttcgctgt catccggcac cagcagagct tgttgtataa ggaatatctt     1140

agtgagaagg agacttggaa aacagagagt aaaacgataa aggaagagaa gcgcaaactg     1200

gaggaccagg ttcagcagga tgccattaag gtgaaagagt acaataacct tctgaatgcg     1260

ttgcagatgg acagcgacga gatgaagaaa atcttggctg agaattcccg gaaaatcacc     1320

gtgctccaag tcaatgagaa gtccctcata agacagtaca ccacactcgt cgaactggaa     1380

agacagctga ggaaggagaa cgaaaaacag aaaaacgagc tgcttagcat ggaggccgaa     1440

gtatgcgaga agataggatg tctgcaaagg ttcaaagaga tggccatatt caagatcgcg     1500

gcactccaga aagtggtcga taactctgtg tctctcagcg agttggaact ggccaataag     1560

cagtacaatg agctgacagc caagtataga gatattctcc aaaaggacaa tatgttggtc     1620

cagaggactt caaatcttga gcacttggag tgtgagaaca tttcacttaa agaacaagta     1680

gagtccatca ataaggagct ggaaatcaca aaagaaaaac tgcacacaat agaacaagca     1740

tgggaacagg aaactaaact gggcaacgaa agcagcatgg ctaagcatct gcggcagact     1800

attcagagcc tgcggaggca attcagcgga gccctgcctc tcgctcagca agagaagttt     1860

tctaaaacaa tgatacagct gcaaaatgat aaactcaaaa tcatgcaaga gatgaagaac     1920

tctcagcagg agcacagaaa catggagaac aagacactgg agatggaact caagttgaaa     1980

gggctggagg agttgatttc tacccttaag gatacaaaag gggcacaaaa ggtcattaac     2040

tggcatatga agatagagga actgagactg caagaactca aactgaatag agagttggtg     2100

aaggacaaag aagagatcaa gtaccttaac aatatcatct cagaatacga gcggactatc     2160

agttcactgg aggaggagat tgttcagcag aacaaattcc atgaggaaag gcagatggct     2220

tgggatcaga gagaagtgga tttggagagg cagctggaca tctttgatag acaacagaat     2280

gagatcctca acgcggcaca gaaattcgaa gaagcgacag gttcaatccc cgatccatct     2340

cttccactcc caaatcagct tgagattgct ctgagaaaga tcaaggaaaa catacggatt     2400

atccttgaga ctagagctac ttgcaagagc ctcgaagaaa aactgaagga gaaggagtct     2460

gcactgcggc ttgcagagca gaatatcctg tctcgggata aggttatcaa cgaactgcgc     2520

ctgaggcttc ctgctaccgc cgagagagag aaactgattg ctgaacttgg acgaaaagaa     2580

atggaaccga aatctcatca cacgctcaag attgcccacc agacaatagc caatatgcag     2640

gccaggctga atcagaaaga ggaggtgctg aagaagtatc aacgcctgct ggagaaagct     2700

agggaggagc agagagagat tgtgaaaaag cacgaagagg acctccatat cctccatcat     2760

cggttggagc ttcaggcaga ttcctccctg aacaagttta agcagacagc ctgggacgat     2820

cagtcccaga aggagtcaca gtgcttgaaa agcgaactgc aggcacagaa ggaagccaat     2880

agccgagccc ctaccacgac tatgagaaac ttggtggaac ggctcaaatc ccagctcgcc     2940

ttgaaagaga agcagcagaa agcactgtcc cgagcgttgc ttgagctgcg agctgagatg     3000

acggcagcag ccgaggagcg catcatttct gctaccagcc aaaaagaggc ccatctgaac     3060

gttcaacaga ttgttgaccg ccacaccagg gagctcaaga cccaagtaga ggaccttaat     3120

gagaacctgc tgaaattgaa agaggcactt aagacctcca agaaccggga gaactctctg     3180

accgacaatc tgaacgatct gaacaatgag ctgcagaaga aacagaaagc ctacaataag     3240

atactgcgag aaaaagaaga aatagaccag gagaacgatg agctcaaacg gcagatcaaa     3300

aggctgacaa gcggcctgca aggcaaacct ctcaccgaca ataagcagtc cctgatcgag     3360

gaactgcagc ggaaagtgaa gaaactcgaa aaccaacttg aagggaaggt ggaagaagtt     3420

gaccttaagc ccatgaaaga gaaaaacgca aaggaggaac tcattagatg ggaggagggc     3480

aaaaagtggc aggccaaaat cgaagggata aggaacaaat tgaaagagaa ggaaggggaa     3540

gtgtttactc tgaccaagca gctcaatact ctcaaggacc tttttgctaa agccgacaaa     3600

gagaaactga ccctgcagag aaagctgaaa acaacaggca tgaccgtgga ccaggtgttg     3660

gggattaggg ccttggagag tgaaaaggag ctggaggagc tgaaa                     3705


<210>  6
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct; amino acid sequence containing codon 
       optimized human CEP290 fragments spliced together in a single 
       open reading frame: aa130-380, aa700-1040; aa1260-1605 and 
       aa1695-1990.

<400>  6

Met Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
1               5                   10                  15      


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
            20                  25                  30          


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
        35                  40                  45              


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
    50                  55                  60                  


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
65                  70                  75                  80  


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
                85                  90                  95      


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
            100                 105                 110         


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
        115                 120                 125             


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
    130                 135                 140                 


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
145                 150                 155                 160 


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
                165                 170                 175     


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
            180                 185                 190         


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
        195                 200                 205             


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
    210                 215                 220                 


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
225                 230                 235                 240 


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys His Leu Lys Ala 
                245                 250                 255     


Gln Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu 
            260                 265                 270         


Arg Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys 
        275                 280                 285             


Ala Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg 
    290                 295                 300                 


Gln Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp 
305                 310                 315                 320 


Gly Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr 
                325                 330                 335     


Leu Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys 
            340                 345                 350         


Asn Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile 
        355                 360                 365             


Arg His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu 
    370                 375                 380                 


Thr Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu 
385                 390                 395                 400 


Glu Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn 
                405                 410                 415     


Leu Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu 
            420                 425                 430         


Ala Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser 
        435                 440                 445             


Leu Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg 
    450                 455                 460                 


Lys Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu 
465                 470                 475                 480 


Val Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile 
                485                 490                 495     


Phe Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu 
            500                 505                 510         


Ser Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys 
        515                 520                 525             


Tyr Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser 
    530                 535                 540                 


Asn Leu Glu His Leu Glu Cys Glu Asn Ile Ser Leu Lys Glu Gln Val 
545                 550                 555                 560 


Glu Ser Ile Asn Lys Glu Leu Glu Ile Thr Lys Glu Lys Leu His Thr 
                565                 570                 575     


Ile Glu Gln Ala Trp Glu Gln Glu Thr Lys Leu Gly Asn Glu Ser Ser 
            580                 585                 590         


Met Ala Lys His Leu Arg Gln Thr Ile Gln Ser Leu Arg Arg Gln Phe 
        595                 600                 605             


Ser Gly Ala Leu Pro Leu Ala Gln Gln Glu Lys Phe Ser Lys Thr Met 
    610                 615                 620                 


Ile Gln Leu Gln Asn Asp Lys Leu Lys Ile Met Gln Glu Met Lys Asn 
625                 630                 635                 640 


Ser Gln Gln Glu His Arg Asn Met Glu Asn Lys Thr Leu Glu Met Glu 
                645                 650                 655     


Leu Lys Leu Lys Gly Leu Glu Glu Leu Ile Ser Thr Leu Lys Asp Thr 
            660                 665                 670         


Lys Gly Ala Gln Lys Val Ile Asn Trp His Met Lys Ile Glu Glu Leu 
        675                 680                 685             


Arg Leu Gln Glu Leu Lys Leu Asn Arg Glu Leu Val Lys Asp Lys Glu 
    690                 695                 700                 


Glu Ile Lys Tyr Leu Asn Asn Ile Ile Ser Glu Tyr Glu Arg Thr Ile 
705                 710                 715                 720 


Ser Ser Leu Glu Glu Glu Ile Val Gln Gln Asn Lys Phe His Glu Glu 
                725                 730                 735     


Arg Gln Met Ala Trp Asp Gln Arg Glu Val Asp Leu Glu Arg Gln Leu 
            740                 745                 750         


Asp Ile Phe Asp Arg Gln Gln Asn Glu Ile Leu Asn Ala Ala Gln Lys 
        755                 760                 765             


Phe Glu Glu Ala Thr Gly Ser Ile Pro Asp Pro Ser Leu Pro Leu Pro 
    770                 775                 780                 


Asn Gln Leu Glu Ile Ala Leu Arg Lys Ile Lys Glu Asn Ile Arg Ile 
785                 790                 795                 800 


Ile Leu Glu Thr Arg Ala Thr Cys Lys Ser Leu Glu Glu Lys Leu Lys 
                805                 810                 815     


Glu Lys Glu Ser Ala Leu Arg Leu Ala Glu Gln Asn Ile Leu Ser Arg 
            820                 825                 830         


Asp Lys Val Ile Asn Glu Leu Arg Leu Arg Leu Pro Ala Thr Ala Glu 
        835                 840                 845             


Arg Glu Lys Leu Ile Ala Glu Leu Gly Arg Lys Glu Met Glu Pro Lys 
    850                 855                 860                 


Ser His His Thr Leu Lys Ile Ala His Gln Thr Ile Ala Asn Met Gln 
865                 870                 875                 880 


Ala Arg Leu Asn Gln Lys Glu Glu Val Leu Lys Lys Tyr Gln Arg Leu 
                885                 890                 895     


Leu Glu Lys Ala Arg Glu Glu Gln Arg Glu Ile Val Lys Lys His Glu 
            900                 905                 910         


Glu Asp Leu His Ile Leu His His Arg Leu Glu Leu Gln Ala Asp Ser 
        915                 920                 925             


Ser Leu Asn Lys Phe Lys Gln Thr Ala Trp Asp Asp Gln Ser Gln Lys 
    930                 935                 940                 


Glu Ser Gln Cys Leu Lys Ser Glu Leu Gln Ala Gln Lys Glu Ala Asn 
945                 950                 955                 960 


Ser Arg Ala Pro Thr Thr Thr Met Arg Asn Leu Val Glu Arg Leu Lys 
                965                 970                 975     


Ser Gln Leu Ala Leu Lys Glu Lys Gln Gln Lys Ala Leu Ser Arg Ala 
            980                 985                 990         


Leu Leu Glu Leu Arg Ala Glu Met  Thr Ala Ala Ala Glu  Glu Arg Ile 
        995                 1000                 1005             


Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His Leu Asn  Val Gln Gln 
    1010                 1015                 1020             


Ile Val  Asp Arg His Thr Arg  Glu Leu Lys Thr Gln  Val Glu Asp 
    1025                 1030                 1035             


Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu Ala Leu  Lys Thr Ser 
    1040                 1045                 1050             


Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn Leu Asn  Asp Leu Asn 
    1055                 1060                 1065             


Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr Asn Lys  Ile Leu Arg 
    1070                 1075                 1080             


Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp Glu Leu  Lys Arg Gln 
    1085                 1090                 1095             


Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly Lys Pro  Leu Thr Asp 
    1100                 1105                 1110             


Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln Arg Lys  Val Lys Lys 
    1115                 1120                 1125             


Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu Glu Val  Asp Leu Lys 
    1130                 1135                 1140             


Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu Leu Ile  Arg Trp Glu 
    1145                 1150                 1155             


Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu Gly Ile  Arg Asn Lys 
    1160                 1165                 1170             


Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr Leu Thr  Lys Gln Leu 
    1175                 1180                 1185             


Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala Asp Lys  Glu Lys Leu 
    1190                 1195                 1200             


Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly Met Thr  Val Asp Gln 
    1205                 1210                 1215             


Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu Lys Glu  Leu Glu Glu 
    1220                 1225                 1230             


Leu Lys  
    1235 


<210>  7
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  7
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgc ccccaaacat       60

caattgg                                                                 67


<210>  8
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  8
ggggaccact ttgtacaaga aagctgggtc ctaatagatc gggaagttaa cagg             54


<210>  9
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  9
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatga cggagaacat       60

aagccaagg                                                               69


<210>  10
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  10
ggggaccact ttgtacaaga aagctgggtc ctaatagatc gggaagttaa cagg             54


<210>  11
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  11
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgc ccccaaacat       60

caattgg                                                                 67


<210>  12
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  12
ggggaccact ttgtacaaga aagctgggtc ctaaagattc agatcctcgg tag              53


<210>  13
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  13
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgc ccccaaacat       60

caattgg                                                                 67


<210>  14
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  14
ggggaccact ttgtacaaga aagctgggtc ctaatccctt tcttggattc cctgc            55


<210>  15
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  15
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatga aaaacacttg       60

catcattgag gac                                                          73


<210>  16
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  16
ggggaccact ttgtacaaga aagctgggtc ctaaagattc agatcctcgg tag              53


<210>  17
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  17
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgc ccccaaacat       60

caattgg                                                                 67


<210>  18
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  18
ggggaccact ttgtacaaga aagctgggtc ctaatccagc agatacttca aatcc            55


<210>  19
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  19
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatga cggagaacat       60

aagccaagg                                                               69


<210>  20
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  20
ggggaccact ttgtacaaga aagctgggtc ctaatccagc agatacttca aatcc            55


<210>  21
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  21
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgc ccccaaacat       60

caattgg                                                                 67


<210>  22
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  22
ggggaccact ttgtacaaga aagctgggtc ctatgttttc agctttctct gcag             54


<210>  23
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  23
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatga cggagaacat       60

aagccaagg                                                               69


<210>  24
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  24
ggggaccact ttgtacaaga aagctgggtc ctaatagatc gggaagttaa cagg             54


<210>  25
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  25
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatga cggagaacat       60

aagccaagg                                                               69


<210>  26
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  26
ggggaccact ttgtacaaga aagctgggtc ctatgttttc agctttctct gcag             54


<210>  27
<211>  68
<212>  DNA
<213>  Homo sapiens

<400>  27
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgc agtcccagaa       60

ggagtcac                                                                68


<210>  28
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  28
ggggaccact ttgtacaaga aagctgggtc ctatgttttc agctttctct gcag             54


<210>  29
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  29
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatga caggcatgac       60

cgtggac                                                                 67


<210>  30
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  30
ggggaccact ttgtacaaga aagctgggtc ctaatagatc gggaagttaa cagg             54


<210>  31
<211>  68
<212>  DNA
<213>  Homo sapiens

<400>  31
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatgc agtcccagaa       60

ggagtcac                                                                68


<210>  32
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  32
ggggaccact ttgtacaaga aagctgggtc ctatttctct ttcatgggct taaggtc          57


<210>  33
<211>  68
<212>  DNA
<213>  Homo sapiens

<400>  33
ggggacaagt ttgtacaaaa aagcaggctt cgaaggagat agaaccatga caggcatgac       60

cgtggacc                                                                68


<210>  34
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  34
ggggaccact ttgtacaaga aagctgggtc ctaatagatc gggaagttaa cagg             54


<210>  35
<211>  36
<212>  PRT
<213>  Gallus gallus

<400>  35

Tyr Asn Lys Met Lys Leu Ile Val Gln Gln Ser Asp Ile Val Met Asp 
1               5                   10                  15      


Gln Leu Arg Lys Glu Asn Glu Gln Tyr Lys Phe Gln Val Gln Glu Leu 
            20                  25                  30          


Ser Asp Gln Leu 
        35      


<210>  36
<211>  36
<212>  PRT
<213>  Meleagris gallopavo

<400>  36

Tyr Asn Lys Met Lys Leu Ile Val Gln Gln Ser Asp Ile Val Met Asp 
1               5                   10                  15      


Gln Leu Arg Lys Glu Asn Glu Gln Tyr Lys Phe Gln Val Gln Glu Leu 
            20                  25                  30          


Ser Asp Gln Leu 
        35      


<210>  37
<211>  36
<212>  PRT
<213>  Rattus rattus

<400>  37

Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Thr Val Met Asp 
1               5                   10                  15      


Gln Ile Lys Lys Glu Asn Glu His Tyr Arg Leu Gln Val Arg Glu Leu 
            20                  25                  30          


Thr Asp Leu Leu 
        35      


<210>  38
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  38

Tyr Asn Arg Met Lys Ala Leu Val His Gln Ser Asp Ala Val Met Asp 
1               5                   10                  15      


Gln Ile Lys Lys Glu Asn Glu His Tyr Arg Leu Gln Val Arg Glu Leu 
            20                  25                  30          


Thr Asp Leu Leu 
        35      


<210>  39
<211>  36
<212>  PRT
<213>  Pongo pygmaeus

<400>  39

Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
1               5                   10                  15      


Gln Ile Lys Lys Glu Asn Asp His Tyr Arg Leu Gln Val Gln Glu Leu 
            20                  25                  30          


Thr Asp Leu Leu 
        35      


<210>  40
<211>  36
<212>  PRT
<213>  Macaca mulatta

<400>  40

Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
1               5                   10                  15      


Gln Leu Lys Lys Glu Asn Asp His Tyr Arg Leu Gln Val Gln Glu Leu 
            20                  25                  30          


Thr Asp Leu Leu 
        35      


<210>  41
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  41

Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
1               5                   10                  15      


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
            20                  25                  30          


Thr Asp Leu Leu 
        35      


<210>  42
<211>  36
<212>  PRT
<213>  Felis catus

<400>  42

Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Ile Met Asp 
1               5                   10                  15      


Gln Leu Lys Lys Glu Asn Asp His Tyr Arg Leu Gln Val Gln Glu Leu 
            20                  25                  30          


Thr Asp Leu Leu 
        35      


<210>  43
<211>  36
<212>  PRT
<213>  Ailuropoda melanoleuca

<400>  43

Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Ile Met Asp 
1               5                   10                  15      


Gln Leu Lys Lys Glu Asn Asp His Tyr Arg Leu Gln Val Gln Glu Leu 
            20                  25                  30          


Thr Asp Leu Leu 
        35      


<210>  44
<211>  36
<212>  PRT
<213>  Danio tweediei

<400>  44

Tyr Asn Lys Met Lys Ile Ala Val Gln Gln Thr Asp Ala Ile Met Asp 
1               5                   10                  15      


Gln Leu Arg Lys Asp Arg Asp His Ala Lys Leu Gln Val Arg Glu Leu 
            20                  25                  30          


Thr Asp Gln Ile 
        35      


