                               SEQUENCE LISTING

<110> ARMAGEN TECHNOLOGIES, INC.
 
<120> COMPOSITIONS AND METHODS RELATED TO STRUCTURES THAT CROSS THE 
      BLOOD BRAIN BARRIER

<130> 28570-712.601

<140> PCT/US2014/047082
<141> 2014-07-17

<150> 61/857,186
<151> 2013-07-22

<150> 61/856,499
<151> 2013-07-19

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 462
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210> 2
<211> 234
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Gly Asn Leu Tyr Trp Leu Gln Gln Gly Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ser 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 3
<211> 627
<212> PRT
<213> Homo sapiens

<400> 3
Glu Ala Pro His Leu Val Gln Val Asp Ala Ala Arg Ala Leu Trp Pro 
1               5                   10                  15      


Leu Arg Arg Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His 
            20                  25                  30          


Ser Gln Ala Asp Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu 
        35                  40                  45              


Ala Tyr Val Gly Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr 
    50                  55                  60                  


His Trp Leu Leu Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly 
65                  70                  75                  80  


Leu Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg 
                85                  90                  95      


Glu Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly 
            100                 105                 110         


His Phe Thr Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp 
        115                 120                 125             


Leu Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala 
    130                 135                 140                 


His Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His 
145                 150                 155                 160 


Asp Phe Asp Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr 
                165                 170                 175     


Asp Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu 
            180                 185                 190         


Gly Gly Pro Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser 
        195                 200                 205             


Trp Gly Leu Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly 
    210                 215                 220                 


Glu Ala Gly Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala 
225                 230                 235                 240 


Arg Ser Ser Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln 
                245                 250                 255     


Ile Arg Gln Leu Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp 
            260                 265                 270         


Glu Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala 
        275                 280                 285             


Asp Val Thr Tyr Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln 
    290                 295                 300                 


Asn Leu Leu Leu Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu 
305                 310                 315                 320 


Ser Asn Asp Asn Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln 
                325                 330                 335     


Arg Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His 
            340                 345                 350         


Val Gln Leu Leu Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala 
        355                 360                 365             


Leu Leu Asp Glu Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr 
    370                 375                 380                 


Val Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg 
385                 390                 395                 400 


Pro Gln Gly Pro Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala 
                405                 410                 415     


Ser Asp Asp Thr Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu 
            420                 425                 430         


Arg Leu Arg Gly Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg 
        435                 440                 445             


Tyr Leu Asp Asn Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu 
    450                 455                 460                 


Gly Arg Pro Val Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala 
465                 470                 475                 480 


Ala Glu Asp Pro Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly 
                485                 490                 495     


Arg Leu Thr Leu Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val 
            500                 505                 510         


His Val Cys Ala Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu 
        515                 520                 525             


Arg Ala Leu Pro Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp 
    530                 535                 540                 


Glu His Val Gly Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser 
545                 550                 555                 560 


Gln Asp Gly Lys Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe 
                565                 570                 575     


Asn Leu Phe Val Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr 
            580                 585                 590         


Arg Val Arg Ala Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp 
        595                 600                 605             


Pro Val Pro Tyr Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro 
    610                 615                 620                 


Gly Asn Pro 
625         


<210> 4
<211> 1091
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Ser 
    450                 455                 460                 


Glu Ala Pro His Leu Val Gln Val Asp Ala Ala Arg Ala Leu Trp Pro 
465                 470                 475                 480 


Leu Arg Arg Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His 
                485                 490                 495     


Ser Gln Ala Asp Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu 
            500                 505                 510         


Ala Tyr Val Gly Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr 
        515                 520                 525             


His Trp Leu Leu Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly 
    530                 535                 540                 


Leu Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg 
545                 550                 555                 560 


Glu Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly 
                565                 570                 575     


His Phe Thr Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp 
            580                 585                 590         


Leu Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala 
        595                 600                 605             


His Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His 
    610                 615                 620                 


Asp Phe Asp Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr 
625                 630                 635                 640 


Asp Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu 
                645                 650                 655     


Gly Gly Pro Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser 
            660                 665                 670         


Trp Gly Leu Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly 
        675                 680                 685             


Glu Ala Gly Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala 
    690                 695                 700                 


Arg Ser Ser Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln 
705                 710                 715                 720 


Ile Arg Gln Leu Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp 
                725                 730                 735     


Glu Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala 
            740                 745                 750         


Asp Val Thr Tyr Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln 
        755                 760                 765             


Asn Leu Leu Leu Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu 
    770                 775                 780                 


Ser Asn Asp Asn Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln 
785                 790                 795                 800 


Arg Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His 
                805                 810                 815     


Val Gln Leu Leu Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala 
            820                 825                 830         


Leu Leu Asp Glu Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr 
        835                 840                 845             


Val Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg 
    850                 855                 860                 


Pro Gln Gly Pro Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala 
865                 870                 875                 880 


Ser Asp Asp Thr Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu 
                885                 890                 895     


Arg Leu Arg Gly Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg 
            900                 905                 910         


Tyr Leu Asp Asn Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu 
        915                 920                 925             


Gly Arg Pro Val Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala 
    930                 935                 940                 


Ala Glu Asp Pro Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly 
945                 950                 955                 960 


Arg Leu Thr Leu Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val 
                965                 970                 975     


His Val Cys Ala Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu 
            980                 985                 990         


Arg Ala Leu Pro Leu Thr Gln Gly  Gln Leu Val Leu Val  Trp Ser Asp 
        995                 1000                 1005             


Glu His  Val Gly Ser Lys Cys  Leu Trp Thr Tyr Glu  Ile Gln Phe 
    1010                 1015                 1020             


Ser Gln  Asp Gly Lys Ala Tyr  Thr Pro Val Ser Arg  Lys Pro Ser 
    1025                 1030                 1035             


Thr Phe  Asn Leu Phe Val Phe  Ser Pro Asp Thr Gly  Ala Val Ser 
    1040                 1045                 1050             


Gly Ser  Tyr Arg Val Arg Ala  Leu Asp Tyr Trp Ala  Arg Pro Gly 
    1055                 1060                 1065             


Pro Phe  Ser Asp Pro Val Pro  Tyr Leu Glu Val Pro  Val Pro Arg 
    1070                 1075                 1080             


Gly Pro  Pro Ser Pro Gly Asn  Pro 
    1085                 1090     


<210> 5
<211> 525
<212> PRT
<213> Homo sapiens

<400> 5
Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
        515                 520                 525 


<210> 6
<211> 989
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Asp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Lys Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser 
    450                 455                 460                 


Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
465                 470                 475                 480 


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
                485                 490                 495     


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
            500                 505                 510         


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
        515                 520                 525             


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
    530                 535                 540                 


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
545                 550                 555                 560 


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
                565                 570                 575     


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
            580                 585                 590         


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
        595                 600                 605             


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
    610                 615                 620                 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
625                 630                 635                 640 


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
                645                 650                 655     


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
            660                 665                 670         


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
        675                 680                 685             


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
    690                 695                 700                 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
705                 710                 715                 720 


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
                725                 730                 735     


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
            740                 745                 750         


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
        755                 760                 765             


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
    770                 775                 780                 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
785                 790                 795                 800 


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
                805                 810                 815     


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
            820                 825                 830         


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
        835                 840                 845             


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
    850                 855                 860                 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
865                 870                 875                 880 


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
                885                 890                 895     


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
            900                 905                 910         


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
        915                 920                 925             


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
    930                 935                 940                 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
945                 950                 955                 960 


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
                965                 970                 975     


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
            980                 985                 


<210> 7
<211> 2979
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gccgccacca tggactggac ctggagggtg ttctgcctgc ttgcagtggc ccccggagcc       60

cacagccagg ttcagctgca gcagtctgga cctgagctgg tgaagcctgg ggctttagtg      120

aagatatcct gcaaggcttc tggttacacc ttcacaaact acgatataca ctgggtgaag      180

cagaggcctg gacagggact tgagtggatt ggatggattt atcctggaga tggtagtact      240

aagtacaatg agaaattcaa gggcaaggcc acactgactg cagacaaatc ctccagcaca      300

gcctacatgc acctcagcag cctgacttct gagaaatctg cagtctattt ctgtgcaaga      360

gagtgggctt actggggcca agggactctg gtcactgtct ctgcagctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctcctg gtagtagttc ctccgaaacg caggccaact cgaccacaga tgctctgaac     1440

gttcttctca tcatcgtgga tgacctgcgc ccctccctgg gctgttatgg ggataagctg     1500

gtgaggtccc caaatattga ccaactggca tcccacagcc tcctcttcca gaatgccttt     1560

gcgcagcaag cagtgtgcgc cccgagccgc gtttctttcc tcactggcag gagacctgac     1620

accacccgcc tgtacgactt caactcctac tggagggtgc acgctggaaa cttctccacc     1680

atcccccagt acttcaagga gaatggctat gtgaccatgt cggtgggaaa agtctttcac     1740

cctgggatat cttctaacca tactgatgat tctccgtata gctggtcttt tccaccttat     1800

catccttcct ctgagaagta tgaaaacact aagacatgtc gagggccaga tggagaactc     1860

catgccaacc tgctttgccc tgtggatgtg ctggatgttc ccgagggcac cttgcctgac     1920

aaacagagca ctgagcaagc catacagttg ttggaaaaga tgaaaacgtc agccagtcct     1980

ttcttcctgg ccgttgggta tcataagcca cacatcccct tcagataccc caaggaattt     2040

cagaagttgt atcccttgga gaacatcacc ctggcccccg atcccgaggt ccctgatggc     2100

ctaccccctg tggcctacaa cccctggatg gacatcaggc aacgggaaga cgtccaagcc     2160

ttaaacatca gtgtgccgta tggtccaatt cctgtggact ttcagcggaa aatccgccag     2220

agctactttg cctctgtgtc atatttggat acacaggtcg gccgcctctt gagtgctttg     2280

gacgatcttc agctggccaa cagcaccatc attgcattta cctcggatca tgggtgggct     2340

ctaggtgaac atggagaatg ggccaaatac agcaattttg atgttgctac ccatgttccc     2400

ctgatattct atgttcctgg aaggacggct tcacttccgg aggcaggcga gaagcttttc     2460

ccttacctcg acccttttga ttccgcctca cagttgatgg agccaggcag gcaatccatg     2520

gaccttgtgg aacttgtgtc tctttttccc acgctggctg gacttgcagg actgcaggtt     2580

ccacctcgct gccccgttcc ttcatttcac gttgagctgt gcagagaagg caagaacctt     2640

ctgaagcatt ttcgattccg tgacttggaa gaggatccgt acctccctgg taatccccgt     2700

gaactgattg cctatagcca gtatccccgg ccttcagaca tccctcagtg gaattctgac     2760

aagccgagtt taaaagatat aaagatcatg ggctattcca tacgcaccat agactatagg     2820

tatactgtgt gggttggctt caatcctgat gaatttctag ctaacttttc tgacatccat     2880

gcaggggaac tgtattttgt ggattctgac ccattgcagg atcacaatat gtataatgat     2940

tcccaaggtg gagatctttt ccagttgttg atgccttga                            2979


<210> 8
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
gccgccacca tggagacccc cgcccagctg ctgttcctgt tgctgctttg gcttccagat       60

actaccggcg acatccagat gacccagtct ccatcctcct tatctgcctc tctgggagaa      120

agagtcagtc tcacttgtcg ggcaagtcag gacattggtg gtaacttata ctggcttcag      180

cagggaccag atggaactat taaacgcctg atctacgcca catccagttt agattctggt      240

gtccccaaaa ggttcagtgg cagtaggtct gggtcagatt attctctcac catcagcagc      300

cttgagtctg aagattttgt agactattac tgtctacagt attctagttc tccgtggacg      360

ttcggtggag gcacaaagct ggaaataaaa cgaactgtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttag            714


