                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Therapeutic fusion protein

<130>  31238 WO

<150>  EP13179056.0
<151>  2013-08-02

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  2
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro 
1               5                   10                  15      


Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser 
            20                  25                  30          


Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu 
        35                  40                  45              


Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys 
    50                  55                  60                  


Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys 
65                  70                  75                  80  


Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val 
                85                  90                  95      


Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp 
            100                 105                 110         


Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu 
        115                 120                 125             


Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile 
    130                 135                 140                 


Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln 
                165                 170                 175     


Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn 
            180                 185                 190         


Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp 
        195                 200                 205             


Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu 
    210                 215                 220                 


Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu 
225                 230                 235                 240 


Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile 
                245                 250                 255     


Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu 
            260                 265                 270         


Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala 
        275                 280                 285             


Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr 
    290                 295                 300                 


Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro 
305                 310                 315                 320 


Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile 
                325                 330                 335     


Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu 
            340                 345                 350         


Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln 
        355                 360                 365             


Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser 
    370                 375                 380                 


Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly 
385                 390                 395                 400 


Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn 
                405                 410                 415     


Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe 
            420                 425                 430         


Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg 
        435                 440                 445             


Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu 
    450                 455                 460                 


Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile 
465                 470                 475                 480 


Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu 
                485                 490                 495     


Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile 
            500                 505                 510         


Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu 
        515                 520                 525             


Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala 
    530                 535                 540                 


Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu 
545                 550                 555                 560 


Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly 
                565                 570                 575     


Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp 
            580                 585                 590         


Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr 
        595                 600                 605             


Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr 
    610                 615                 620                 


Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn 
625                 630                 635                 640 


Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly 
                645                 650                 655     


Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu 
            660                 665                 670         


Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu 
        675                 680                 685             


Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val 
    690                 695                 700                 


Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile 
705                 710                 715                 720 


Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg 
                725                 730                 735     


Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 750 


<210>  3
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ala Ser Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Gly Asn Thr His Lys Pro Tyr Gly Tyr Val Arg Tyr 
            100                 105                 110         


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  4
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ile Asn Ala Ser Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Lys Gly Asn Thr His Lys Pro Tyr Gly Tyr Val Arg Tyr Phe Asp 
1               5                   10                  15      


Val 
    


<210>  8
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Gln Ile Tyr Asn Met Pro Ile 
1               5               


<210>  11
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain antibody construct

<400>  11

Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ala Ser Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Gly Asn Thr His Lys Pro Tyr Gly Tyr Val Arg Tyr 
            100                 105                 110         


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
465                 470                 475                 480 


Pro Ala Ser Leu Ser Ala Ser Leu Glu Glu Ile Val Thr Ile Thr Cys 
                485                 490                 495     


Gln Ala Ser Gln Asp Ile Gly Asn Trp Leu Ala Trp Tyr Gln Gln Lys 
            500                 505                 510         


Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Gly Ala Thr Ser Leu Ala 
        515                 520                 525             


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Gln Phe 
    530                 535                 540                 


Ser Leu Lys Ile Ser Arg Val Gln Val Glu Asp Ile Gly Ile Tyr Tyr 
545                 550                 555                 560 


Cys Leu Gln Ala Tyr Asn Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys 
                565                 570                 575     


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
            580                 585                 590         


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
        595                 600                 605             


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
    610                 615                 620                 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
625                 630                 635                 640 


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
                645                 650                 655     


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
            660                 665                 670         


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    690                 695                 700                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu 
705                 710                 715                 720 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
                725                 730                 735     


Leu Thr Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            740                 745                 750         


Met His Trp Ile Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Ile Ala 
        755                 760                 765             


Met Ile Tyr Tyr Asp Ser Ser Lys Met Asn Tyr Ala Asp Thr Val Lys 
    770                 775                 780                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
785                 790                 795                 800 


Glu Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                805                 810                 815     


Val Pro Thr Ser His Tyr Val Val Asp Val Trp Gly Gln Gly Val Ser 
            820                 825                 830         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        835                 840                 845             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    850                 855                 860                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
865                 870                 875                 880 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                885                 890                 895     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            900                 905                 910         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        915                 920                 925             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    930                 935                 940 


<210>  12
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain antibody construct

<400>  12

Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ala Ser Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Gly Asn Thr His Lys Pro Tyr Gly Tyr Val Arg Tyr 
            100                 105                 110         


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys 
465                 470                 475                 480 


Ile Lys Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu 
                485                 490                 495     


Pro Cys Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg 
            500                 505                 510         


Asn Val Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu 
        515                 520                 525             


Arg Asp Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys 
    530                 535                 540                 


Thr Glu Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser 
545                 550                 555                 560 


Cys Ile Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu 
                565                 570                 575     


Lys Leu Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp 
            580                 585                 590         


Glu Gln Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln 
        595                 600                 605             


Leu Asn Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly 
    610                 615                 620                 


Thr Asp Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro 
625                 630                 635                 640 


Arg Leu Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr 
                645                 650                 655     


Lys Glu Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg 
            660                 665                 670         


Leu Ile Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala 
        675                 680                 685             


Leu Glu Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala 
    690                 695                 700                 


Thr Ala Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys 
705                 710                 715                 720 


Met Thr Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly 
                725                 730                 735     


Lys Pro Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val 
            740                 745                 750         


Asn Ile Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu 
        755                 760                 765             


Tyr Leu Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp 
    770                 775                 780                 


Leu Gln Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser 
785                 790                 795                 800 


Leu Ser Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu 
                805                 810                 815     


Tyr Gly Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr 
            820                 825                 830         


Val Asn Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala 
        835                 840                 845             


Ala Phe Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln 
    850                 855                 860                 


Ile Arg Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp 
865                 870                 875                 880 


Ala Glu Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu 
                885                 890                 895     


Arg Ile Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn 
            900                 905                 910         


Asn Glu Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn 
        915                 920                 925             


Ile Ile Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu 
    930                 935                 940                 


Arg Glu Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val 
945                 950                 955                 960 


Asn Ala Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly 
                965                 970                 975     


Ile Leu Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn 
            980                 985                 990         


Tyr Gly Gly Ile Gly Met Val Ile  Gly His Glu Ile Thr  His Gly Phe 
        995                 1000                 1005             


Asp Asp  Asn Gly Arg Asn Phe  Asn Lys Asp Gly Asp  Leu Val Asp 
    1010                 1015                 1020             


Trp Trp  Thr Gln Gln Ser Ala  Ser Asn Phe Lys Glu  Gln Ser Gln 
    1025                 1030                 1035             


Cys Met  Val Tyr Gln Tyr Gly  Asn Phe Ser Trp Asp  Leu Ala Gly 
    1040                 1045                 1050             


Gly Gln  His Leu Asn Gly Ile  Asn Thr Leu Gly Glu  Asn Ile Ala 
    1055                 1060                 1065             


Asp Asn  Gly Gly Leu Gly Gln  Ala Tyr Arg Ala Tyr  Gln Asn Tyr 
    1070                 1075                 1080             


Ile Lys  Lys Asn Gly Glu Glu  Lys Leu Leu Pro Gly  Leu Asp Leu 
    1085                 1090                 1095             


Asn His  Lys Gln Leu Phe Phe  Leu Asn Phe Ala Gln  Val Trp Cys 
    1100                 1105                 1110             


Gly Thr  Tyr Arg Pro Glu Tyr  Ala Val Asn Ser Ile  Lys Thr Asp 
    1115                 1120                 1125             


Val His  Ser Pro Gly Asn Phe  Arg Ile Ile Gly Thr  Leu Gln Asn 
    1130                 1135                 1140             


Ser Ala  Glu Phe Ser Glu Ala  Phe His Cys Arg Lys  Asn Ser Tyr 
    1145                 1150                 1155             


Met Asn  Pro Glu Lys Lys Cys  Arg Val Trp 
    1160                 1165             


<210>  13
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain antibody construct

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


