
                                SEQUENCE LISTING

<110> Agensys, Inc. 
      PEREIRA, Daniel Sousa
      MALIK, Faisil Hayat
      SNYDER, Josh
      BUTTERWORTH, Leslie Renee
      HSU, Ssucheng Jeff
      YANG, Peng
      GUEVARA, Claudia Isabel
      

<120> ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO CD37 PROTEINS

<130> 511582008940

<140> Not Yet Assigned    
<141> Concurrently Herewith             

<150> US 61/861,321       
<151> 2013-08-01  

<160> 12

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1263
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (122)...(967)

<400> 1
ttcctttctc tctcagctct ccgtctctct ttctctctca gcctctttct ttctccctgt 60
ctcccccact gtcagcacct cttctgtgtg gtgagtggac cgcttacccc actaggtgaa 120
g atg tca gcc cag gag agc tgc ctc agc ctc atc aag tac ttc ctc ttc 169
  Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe
   1               5                   10                  15
 
gtt ttc aac ctc ttc ttc ttc gtc ctc ggc agc ctg atc ttc tgc ttc   217
Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe
             20                  25                  30
 
ggc atc tgg atc ctc att gac aag acc agc ttc gtg tcc ttt gtg ggc   265
Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly
         35                  40                  45
 
ttg gcc ttc gtg cct ctg cag atc tgg tcc aaa gtc ctg gcc atc tca   313
Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser
     50                  55                  60
 
gga atc ttc acc atg ggc atc gcc ctc ctg ggt tgt gtg ggg gcc ctc   361
Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu
 65                  70                  75                  80
 
aag gag ctc cgc tgc ctc ctg ggc ctg tat ttt ggg atg ctg ctg ctc   409
Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu
                 85                  90                  95
 
ctg ttt gcc aca cag atc acc ctg gga atc ctc atc tcc act cag cgg   457
Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg
            100                 105                 110
 
gcc cag ctg gag cga agc ttg cgg gac gtc gta gag aaa acc atc caa   505
Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln
        115                 120                 125
 
aag tac ggc acc aac ccc gag gag acc gcg gcc gag gag agc tgg gac   553
Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp
    130                 135                 140
 
tat gtg cag ttc cag ctg cgc tgc tgc ggc tgg cac tac ccg cag gac   601
Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp
145                 150                 155                 160
 
tgg ttc caa gtc ctc atc ctg aga ggt aac ggg tcg gag gcg cac cgc   649
Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg
                165                 170                 175
 
gtg ccc tgc tcc tgc tac aac ttg tcg gcg acc aac gac tcc aca atc   697
Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile
            180                 185                 190
 
cta gat aag gtg atc ttg ccc cag ctc agc agg ctt gga cac ctg gcg   745
Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala
        195                 200                 205
 
cgg tcc aga cac agt gca gac atc tgc gct gtc cct gca gag agc cac   793
Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His
    210                 215                 220
 
atc tac cgc gag ggc tgc gcg cag ggc ctc cag aag tgg ctg cac aac   841
Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn
225                 230                 235                 240
 
aac ctt att tcc ata gtg ggc att tgc ctg ggc gtc ggc cta ctc gag   889
Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu
                245                 250                 255
 
ctc ggg ttc atg acg ctc tcg ata ttc ctg tgc aga aac ctg gac cac   937
Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His
            260                 265                 270
 
gtc tac aac cgg ctc gct cga tac cgt tag gccccgccct ccccaaagtc     987
Val Tyr Asn Arg Leu Ala Arg Tyr Arg
        275                 280
 
ccgccccgcc cccgtcacgt gcgctgggca cttccctgct gcctgtaaat atttgtttaa 1047
tccccagttc gcctggagcc ctccgccttc acattcccct ggggacccac gtggctgcgt 1107
gcccctgctg ctgtcacctc tcccacggga cctggggctt tcgtccacag cttcctgtcc 1167
ccatctgtcg gcctaccacc acccacaaga ttatttttca cccaaacctc aaataaatcc 1227
cctgcgtttt tggtaaaaaa aaaaaaaaaa aaaaaa                           1263

<210> 2
<211> 281
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe
 1               5                  10                  15      
Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe
            20                  25                  30          
Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly
        35                  40                  45              
Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser
    50                  55                  60                  
Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu
65                  70                  75                  80  
Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu
                85                  90                  95      
Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg
            100                 105                 110         
Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln
        115                 120                 125             
Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp
    130                 135                 140                 
Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp
145                 150                 155                 160 
Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg
                165                 170                 175     
Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile
            180                 185                 190         
Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala
        195                 200                 205             
Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His
    210                 215                 220                 
Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn
225                 230                 235                 240 
Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu
                245                 250                 255     
Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His
            260                 265                 270         
Val Tyr Asn Arg Leu Ala Arg Tyr Arg
        275                 280     


<210> 3
<211> 1326
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(1326)

<220> 
<221> misc_feature   
<222> (1)...(1326)
<223> HvCD37-6b15.1.1 heavy chain

<220> 
<221> misc_feature   
<222> (1)...(345)
<223> heavy chain variable region

<220> 
<221> misc_feature   
<222> (346)...(1326)
<223> heavy chain human IgG2 constant region

<400> 3
cag gtg cag cta cag cag tgg ggc gca gga ctg ttg aag cct tcg gag   48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                   10                  15
 
acc ctg tcc ctc acc tgc gct gtc tat ggt ggg tcc ttc agt cct tac   96
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Pro Tyr
             20                  25                  30
 
tac tgg agc tgg atc cgc cag ccc cca ggg aag ggg ttg gag tgg att   144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
         35                  40                  45
 
ggg gaa atc aat cat agt gga agc acc aac tac aac ccg tcc ctc aag   192
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
     50                  55                  60
 
agt cga gtc acc att tca gta gac acg tcc aag aac cag ttc tcc ctg   240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
 65                  70                  75                  80
 
aag ctg agc tct gtg acc gcc gcg gac acg gct gtc tat tac tgt gcg   288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                 85                  90                  95
 
agg aga gct ggg gac ttt gac tac tgg ggc cag gga acc ctg gtc acc   336
Arg Arg Ala Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110
 
gtc tcc tca gca tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc   384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125
 
tgc tcc agg agc acc tcc gag agc aca gcg gcc ctg ggc tgc ctg gtc   432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140
 
aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gct   480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160
 
ctg acc agc ggc gtg cac acc ttc cca gct gtc cta cag tcc tca gga   528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175
 
ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc aac ttc ggc   576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly
            180                 185                 190
 
acc cag acc tac acc tgc aac gta gat cac aag ccc agc aac acc aag   624
Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
        195                 200                 205
 
gtg gac aag aca gtt gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc   672
Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys
    210                 215                 220
 
cca gca cca cct gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa   720
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
225                 230                 235                 240
 
ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg   768
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                245                 250                 255
 
gtg gtg gac gtg agc cac gaa gac ccc gag gtc cag ttc aac tgg tac   816
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
            260                 265                 270
 
gtg gac ggc gtg gag gtg cat aat gcc aag aca aag cca cgg gag gag   864
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        275                 280                 285
 
cag ttc aac agc acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac   912
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
    290                 295                 300
 
cag gac tgg ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa   960
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
305                 310                 315                 320
 
ggc ctc cca gcc ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag   1008
Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
                325                 330                 335
 
ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg   1056
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
            340                 345                 350
 
acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc   1104
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        355                 360                 365
 
agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac   1152
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    370                 375                 380
 
tac aag acc aca cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc   1200
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
385                 390                 395                 400
 
tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc   1248
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                405                 410                 415
 
ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag   1296
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            420                 425                 430
 
aag agc ctc tcc ctg tct ccg ggt aaa taa                           1326
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440
 

<210> 4
<211> 441
<212> PRT
<213> Homo sapiens

<400> 4
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Pro Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Arg Ala Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly
            180                 185                 190         
Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys
    210                 215                 220                 
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
225                 230                 235                 240 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                245                 250                 255     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
            260                 265                 270         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        275                 280                 285             
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
    290                 295                 300                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
305                 310                 315                 320 
Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
                325                 330                 335     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
            340                 345                 350         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        355                 360                 365             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    370                 375                 380                 
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
385                 390                 395                 400 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                405                 410                 415     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            420                 425                 430         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440     


<210> 5
<211> 639
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(639)

<220> 
<221> misc_feature   
<222> (1)...(639)
<223> HvCD37-6b15.1.1 light chain

<220> 
<221> misc_feature   
<222> (1)...(318)
<223> light chain variable region

<220> 
<221> misc_feature   
<222> (319)...(639)
<223> human kappa constant region

<400> 5
gac atc cag atg acc cag tct cct tcc acc ctg tct gca tct gtt gga   48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                   10                  15
 
gac aga gtc acc atc act tgc cgg gcc agt cag agt att agt agc tgg   96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
             20                  25                  30
 
ttg gcc tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc   144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45
 
tat aag gcg tct agt tta gaa agt ggg gtc cca tca agg ttt agc ggc   192
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60
 
agt gga tct ggg aca gaa ttc act ctc acc atc agc agc ctg cag cct   240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80
 
gat gat ttt gca act tat tac tgc caa cag tat aat agt tac att ttt   288
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ile Phe
                 85                  90                  95
 
ggc cag ggg acc aag ctg gag atc aaa cgg act gtg gct gca cca tct   336
Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser
            100                 105                 110
 
gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act gcc   384
Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
        115                 120                 125
 
tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa gta   432
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
    130                 135                 140
 
cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag agt   480
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser
145                 150                 155                 160
 
gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc acc   528
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr
                165                 170                 175
 
ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc tgc   576
Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys
            180                 185                 190
 
gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc aac   624
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn
        195                 200                 205
 
agg gga gag tgt tag                                               639
Arg Gly Glu Cys
    210
 

<210> 6
<211> 212
<212> PRT
<213> Homo sapiens

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ile Phe
                85                  90                  95      
Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser
            100                 105                 110         
Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
        115                 120                 125             
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
    130                 135                 140                 
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser
145                 150                 155                 160 
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr
                165                 170                 175     
Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys
            180                 185                 190         
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn
        195                 200                 205             
Arg Gly Glu Cys
    210         


<210> 7
<211> 441
<212> PRT
<213> Homo sapiens

<220> 
<221> CHAIN        
<222> (1)...(441)
<223> HvCD37-6b15.1.1 heavy chain

<220> 
<221> SITE        
<222> (1)...(115)
<223> heavy chain variable region

<220> 
<221> SITE        
<222> (116)...(441)
<223> human IgG2 constant region

<400> 7
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Pro Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Arg Ala Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        115                 120                 125             
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly
            180                 185                 190         
Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
        195                 200                 205             
Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys
    210                 215                 220                 
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
225                 230                 235                 240 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                245                 250                 255     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
            260                 265                 270         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        275                 280                 285             
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
    290                 295                 300                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
305                 310                 315                 320 
Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
                325                 330                 335     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
            340                 345                 350         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        355                 360                 365             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    370                 375                 380                 
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
385                 390                 395                 400 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                405                 410                 415     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            420                 425                 430         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440     


<210> 8
<211> 212
<212> PRT
<213> Homo sapiens

<220> 
<221> CHAIN        
<222> (1)...(212)
<223> HvCD37-6b15.1.1 light chain

<220> 
<221> SITE        
<222> (1)...(106)
<223> light chain variable region

<220> 
<221> SITE        
<222> (107)...(212)
<223> human kappa constant region

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ile Phe
                85                  90                  95      
Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser
            100                 105                 110         
Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
        115                 120                 125             
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
    130                 135                 140                 
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser
145                 150                 155                 160 
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr
                165                 170                 175     
Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys
            180                 185                 190         
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn
        195                 200                 205             
Arg Gly Glu Cys
    210         


<210> 9
<211> 346
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(346)

<400> 9
cag gtg cag cta cag cag tgg ggc gca gga ctg ttg aag cct tcg gag   48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                   10                  15
 
acc ctg tcc ctc acc tgc gct gtc tat ggt ggg tcc ttc agt cct tac   96
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Pro Tyr
             20                  25                  30
 
tac tgg agc tgg atc cgc cag ccc cca ggg aag ggg ttg gag tgg att   144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
         35                  40                  45
 
ggg gaa atc aat cat agt gga agc acc aac tac aac ccg tcc ctc aag   192
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
     50                  55                  60
 
agt cga gtc acc att tca gta gac acg tcc aag aac cag ttc tcc ctg   240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
 65                  70                  75                  80
 
aag ctg agc tct gtg acc gcc gcg gac acg gct gtc tat tac tgt gcg   288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                 85                  90                  95
 
agg aga gct ggg gac ttt gac tac tgg ggc cag gga acc ctg gtc acc   336
Arg Arg Ala Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110
 
gtc tcc tca g                                                     346
Val Ser Ser
        115
 

<210> 10
<211> 115
<212> PRT
<213> Homo sapiens

<400> 10
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Pro Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Arg Ala Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 11
<211> 318
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(318)

<400> 11
gac atc cag atg acc cag tct cct tcc acc ctg tct gca tct gtt gga   48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                   10                  15
 
gac aga gtc acc atc act tgc cgg gcc agt cag agt att agt agc tgg   96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
             20                  25                  30
 
ttg gcc tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc   144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45
 
tat aag gcg tct agt tta gaa agt ggg gtc cca tca agg ttt agc ggc   192
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60
 
agt gga tct ggg aca gaa ttc act ctc acc atc agc agc ctg cag cct   240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80
 
gat gat ttt gca act tat tac tgc caa cag tat aat agt tac att ttt   288
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ile Phe
                 85                  90                  95
 
ggc cag ggg acc aag ctg gag atc aaa cgg                           318
Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105
 

<210> 12
<211> 106
<212> PRT
<213> Homo sapiens

<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ile Phe
                85                  90                  95      
Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105     

