
                                SEQUENCE LISTING 


<110>  Oncolytics Biotech Inc.
 
<120>  METHODS OF TREATING TAXANE NAVE SUBJECTS WITH 
	PRIMARY TUMORS OR WITH METASTATIC CANCER 

<130>  32894-2022

<150>  61/863,626
<151>  2013-08-08

<150>  61/863,631
<151>  2013-08-08

<160>  30     

<170>  PatentIn version 3.5

<210> 1
<211> 1416
<212> DNA
<213> Reovirus

<400> 1
gctattggtc ggatggatcc tcgcctacgt gaagaagtag tacggctgat aatcgcatta 60
acgagtgata atggagcatc actgtcaaaa gggcttgaat caagggtctc ggcgctcgag 120
aagacgtctc aaatacactc tgatactatc ctccggatca cccagggact cgatgatgca 180
aacaaacgaa tcatcgctct tgagcaaagt cgggatgact tggttgcatc agtcagtgat 240
gctcaacttg caatctccag attggaaagc tctatcggag ccctccaaac agttgtcaat 300
ggacttgatt cgagtgttac ccagttgggt gctcgagtgg gacaacttga gacaggactt 360
gcagagctac gcgttgatca cgacaatctc gttgcgagag tggatactgc agaacgtaac 420
attggatcat tgaccactga gctatcaact ctgacgttac gagtaacatc catacaagcg 480
gatttcgaat ctaggatatc cacgttagag cgcacggcgg tcactagcgc gggagctccc 540
ctctcaatcc gtaataaccg tatgaccatg ggattaaatg atggactcac gttgtcaggg 600
aataatctcg ccatccgatt gccaggaaat acgggtctga atattcaaaa tggtggactt 660
cagtttcgat ttaatactga tcaattccag atagttaata ataacttgac tctcaagacg 720
actgtgtttg attctatcaa ctcaaggata ggcgcaactg agcaaagtta cgtggcgtcg 780
gcagtgactc ccttgagatt aaacagtagc acgaaggtgc tggatatgct aatagacagt 840
tcaacacttg aaattaattc tagtggacag ctaactgtta gatcgacatc cccgaatttg 900
aggtatccga tagctgatgt tagcggcggt atcggaatga gtccaaatta taggtttagg 960
cagagcatgt ggataggaat tgtctcctat tctggtagtg ggctgaattg gagggtacag 1020
gtgaactccg acatttttat tgtagatgat tacatacata tatgtcttcc agcttttgac 1080
ggtttctcta tagctgacgg tggagatcta tcgttgaact ttgttaccgg attgttacca 1140
ccgttactta caggagacac tgagcccgct tttcataatg acgtggtcac atatggagca 1200
cagactgtag ctatagggtt gtcgtcgggt ggtgcgcctc agtatatgag taagaatctg 1260
tgggtggagc agtggcagga tggagtactt cggttacgtg ttgagggggg tggctcaatt 1320
acgcactcaa acagtaagtg gcctgccatg accgtttcgt acccgcgtag tttcacgtga 1380
ggatcagacc accccgcggc actggggcat ttcatc                           1416

<210> 2
<211> 1331
<212> DNA
<213> Reovirus

<400> 2
gctattcgct ggtcagttat ggctcgcgct gcgttcctat tcaagactgt tgggtttggt 60
ggtctgcaaa atgtgccaat taacgacgaa ctatcttcac atctactccg agctggtaat 120
tcaccatggc agttaacaca gtttttagac tggataagcc ttgggagggg tttagctaca 180
tcggctctcg ttccgacggc tgggtcaaga tactatcaaa tgagttgcct tctaagtggc 240
actctccaga ttccgttccg tcctaaccac cgatggggag acattaggtt cttacgctta 300
gtgtggtcag ctcctactct cgatggatta gtcgtagctc caccacaagt tttggctcag 360
cccgctttgc aagcacaggc agatcgagtg tacgactgcg atgattatcc atttctagcg 420
cgtgatccaa gattcaaaca tcgggtgtat cagcaattga gtgctgtaac tctacttaac 480
ttgacaggtt ttggcccgat ttcctacgtt cgagtggatg aagatatgtg gagtggagat 540
gtgaaccagc ttctcatgaa ctatttcggg cacacgtttg cagagattgc atacacattg 600
tgtcaagcct cggctaatag gccttgggaa tatgacggta catatgctag gatgactcag 660
attgtgttat ccttgttctg gctatcgtat gtcggtgtaa ttcatcagca gaatacgtat 720
cggacattct attttcagtg taatcggcga ggtgacgccg ctgaggtgtg gattctttct 780
tgttcgttga accattccgc acaaattaga ccgggtaatc gtagcttatt cgttatgcca 840
actagcccag attggaacat ggacgtcaat ttgatcctga gttcaacgtt gacggggtgt 900
ttgtgttcgg gttcacagct gccactgatt gacaataatt cagtacctgc agtgtcgcgt 960
aacatccatg gctggactgg tagagctggt aaccaattgc atgggttcca ggtgagacga 1020
atggtgactg aattttgtga caggttgaga cgcgatggtg tcatgaccca agctcagcag 1080
aatcaagttg aagcgttggc agatcagact caacagttta agagggacaa gctcgaaacg 1140
tgggcgagag aagacgatca atataatcag gctcatccca actccacaat gttccgtacg 1200
aaaccattta cgaatgcgca atggggacga ggtaatacgg gggcgactag tgccgcgatt 1260
gcagccctta tctgatcgtc ttggagtgag ggggtccccc cacacacctc acgactgacc 1320
acacattcat c                                                      1331

<210> 3
<211> 1198
<212> DNA
<213> Reovirus

<400> 3
gctaaagtca cgcctgtcgt cgtcactatg gcttcctcac tcagagctgc gatctccaag 60
atcaagaggg atgacgtcgg tcagcaagtt tgtcctaatt atgtcatgct gcggtcctct 120
gtcacaacaa aggtggtacg aaatgtggtt gagtatcaaa ttcgtacggg cggattcttt 180
tcgtgcttag ctatgctaag gccactccag tacgctaagc gtgagcgttt gcttggtcag 240
aggaatctgg aacgtatatc gactagggat atccttcaga ctcgtgattt acactcacta 300
tgtatgccaa ctcctgatgc gccaatgtct aatcatcaag catccaccat gagagagctg 360
atttgcagtt acttcaaggt cgatcatgcg gatgggttga aatatatacc catggatgag 420
agatactctc cgtcatcact tgccagattg tttaccatgg gcatggctgg gctgcacatt 480
accactgagc catcttataa gcgtgttccg attatgcact tagctgcgga cttggactgt 540
atgacgctgg ctctacctta catgattacg cttgatggtg atactgtggt tcctgtcgct 600
ccaacactgt cagcggaaca gcttctggac gacggactca aaggattagc atgcatggat 660
atctcctatg gatgtgaggt ggacgcgaat agccggccgg ctggtgatca gagtatggac 720
tcttcacgct gcatcaacga gttgtattgc gaggagacag cagaagccat ctgtgtgctt 780
aagacatgcc ttgtgttaaa ttgcatgcag tttaaacttg agatggatga cctagcacat 840
aacgctgctg agctggacaa gatacagatg atgataccct tcagtgagcg tgtttttagg 900
atggcctcgt cctttgcgac tattgatgcc cagtgtttta ggttttgcgt gatgatgaag 960
gataaaaatc tgaaaataga tatgcgtgaa acgacgagac tgtggactcg ttcagcatca 1020
gatgattctg tggccacgtc atctttaagt atttccctgg accggggtcg atgggtggcg 1080
gctgacgcca gtgatgctag actgctggtt tttccgattc gcgtgtaatg ggtgagtgag 1140
ctgatgtggt cgccaagaca tgtgccggtg tcttggtggt gggtgacgcc taatcatc   1198

<210> 4
<211> 1196
<212> DNA
<213> Reovirus

<400> 4
gctatttttg cctcttccca gacgttgtcg caatggaggt gtgcttgccc aacggtcatc 60
aggtcgtgga cttaattaac aacgcttttg aaggtcgtgt atcaatctac agcgcgcaag 120
agggatggga caaaacaatc tcagcacagc cagatatgat ggtatgtggt ggcgccgtcg 180
tttgcatgca ttgtctaggt gttgttggat ctctacaacg caagctgaag catttgcctc 240
accatagatg taatcaacag atccgtcatc aggattacgt cgatgtacag ttcgcagacc 300
gtgttactgc tcactggaag cggggtatgc tgtccttcgt tgcgcagatg cacgagatga 360
tgaatgacgt gtcgccagat gacctggatc gtgtgcgtac tgagggaggt tcactagtgg 420
agctgaaccg gcttcaggtt gacccaaatt caatgtttag atcaatacac tcaagttgga 480
cagatccttt gcaggtggtg gacgaccttg acactaagct ggatcagtac tggacagcct 540
taaacctgat gatcgactca tccgacttga tacccaactt tatgatgaga gacccatcac 600
acgcgttcaa tggtgtgaaa ctgaagggag atgctcgtca aacccaattc tccaggactt 660
ttgattcgag atcgagtttg gaatggggtg tgatggttta tgattactct gagctggatc 720
atgatccatc gaagggccgt gcttacagaa aggaattggt gacgccagct cgagatttcg 780
gtcactttgg attatcccat tattctaggg cgactacccc aatccttgga aagatgccgg 840
ccgtattctc aggaatgttg actgggaact gtaaaatgta tccattcatt aaaggaacgg 900
ctaagctgaa gacagtgcgc aagctagtgg aggcagtcaa tcatgcttgg ggtgtcgaga 960
agattagata tgctcttggg ccaggtggca tgacgggatg gtacaatagg actatgcaac 1020
aggcccccat tgtgctaact cctgctgctc tcacaatgtt cccagatacc atcaagtttg 1080
gggatttgaa ttatccagtg atgattggcg atccgatgat tcttggctaa acacccccat 1140
cttcacagcg ccgggcttga ccaacctggt gtgacgtggg acaggcttca ttcatc     1196

<210> 5
<211> 2304
<212> DNA
<213> Reovirus

<400> 5
gctattcgcg gtcatggctt acatcgcagt tcctgcggtg gtggattcac gttcgagtga 60
ggctattgga ctgctagaat cgtttggagt agacgctggg gctgacgcga atgacgtttc 120
atatcaagat catgactatg tgttggatca gttacagtac atgttagatg gatatgaggc 180
tggtgacgtt atcgatgcac tcgtccacaa gaattggtta catcactctg tctattgctt 240
gttgccaccc aaaagtcaac tattagagta ttggaaaagt aatccttcag cgataccgga 300
caacgttgat cgtcggcttc gtaaacgact aatgctaaag aaagatctca ggaaagatga 360
tgaatacaat cagctagcgc gtgctttcaa gatatcggat gtctacgcac ctctcatctc 420
atccacgacg tcaccgatga caatgataca gaacttgaat cgaggcgaga tcgtgtacac 480
cacgacggac agggtaatag gggctagaat cttgttatat gctcctagaa agtactatgc 540
gtcaactctg tcatttacta tgactaagtg catcattccg tttggtaaag aggtgggtcg 600
tgttcctcac tctcgattta atgttggcac atttccgtca attgctaccc cgaaatgttt 660
tgtcatgagt ggggttgata ttgagtccat cccaaatgaa tttatcaagt tgttttacca 720
gcgcgtcaag agtgttcacg ctaacatact aaatgacata tctcctcaga tcgtctctga 780
catgataaac agaaagcgtc tgcgcgttca tactccatca gatcgtcgag ccgcgcagtt 840
gatgcatttg ccttaccatg ttaaacgagg agcgtctcac gtcgacgttt acaaggtgga 900
tgttgtagac atgttgttcg aggtagtgga tgtggccgat gggttgcgca acgtatctag 960
gaaactaact atgcataccg ttcctgtatg tattcttgaa atgttgggta ttgagattgc 1020
ggactattgc attcgtcaag aggatggaat gctcacagat tggttcctac ttttaaccat 1080
gctatctgat ggcttgactg atagaaggac gcattgtcaa tacttgatta atccgtcaag 1140
tgtgcctcct gatgtgatac ttaacatctc aattactgga tttataaata gacatacaat 1200
cgatgtcatg cctgacatat atgacttcgt taaacccatt ggcgctgtgc tgcctaaggg 1260
atcatttaaa tcaacaatta tgagagttct tgattcaata tcaatattag gaatccaaat 1320
catgccgcgc gcgcatgtag ttgactcaga tgaggtgggc gagcaaatgg agcctacgtt 1380
tgagcaggcg gttatggaga tatacaaagg gattgctggc gttgactcgc tggatgatct 1440
catcaagtgg gtgttgaact cggatctcat tccgcatgat gacaggcttg gtcaattatt 1500
tcaagcgttt ttgcctctcg caaaggactt attagctcca atggccagaa agttttatga 1560
taactcaatg agtgagggta gattgctaac attctctcat gccgacagtg agttgctgaa 1620
cgcaaattat tttggtcatt tattgcgact aaaaatacca tatattacag aggttaatct 1680
gatgattcgc aagaatcgtg agggtggaga gctatttcag cttgtgttat cttatctata 1740
taaaatgtat gctactagcg cgcagcctaa atggtttgga tcattattgc gattgttaat 1800
atgtccctgg ttacatatgg agaaattaat aggagaagca gacccggcat ctacgtcggc 1860
tgaaattggg tggcatatcc ctcgtgaaca gctgatgcaa gatggatggt gtggatgtga 1920
agacggattc attccctatg ttagcatacg tgcgccaaga ctggttatag aggagttgat 1980
ggagaagaac tggggccaat atcatgccca agttattgtc actgatcagc ttgtcgtagg 2040
cgaaccgcgg agggtatctg ctaaggctgt gatcaagggt aaccacttac cagttaagtt 2100
agtttcacga tttgcatgtt tcacattgac ggcgaagtat gagatgaggc tttcgtgcgg 2160
ccatagcact ggacgtggag ctgcatacag tgcgagacta gctttccgat ctgacttggc 2220
gtgatccgtg acatgcgtag tgtgacacct gctcctaggt caatgggggt agggggcggg 2280
ctaagactac gtacgcgctt catc                                        2304

<210> 6
<211> 2204
<212> DNA
<213> Reovirus

<400> 6
ggctaatctg ctgaccgtta ctctgcaaag atggggaacg cttcctctat cgttcagacg 60
atcaacgtca ctggagatgg caatgtattt aaaccatcag ctgaaacttc atctaccgct 120
gtaccatcgt taagcttatc acctggaatg ctgaatcccg gaggggtacc atggattgct 180
gttggagatg agacatctgt gacttcacca ggcgcattac gtcgaatgac gtcaaaggac 240
atcccggaca cggcaataat caacacagac aattcatcag gcgccgtgcc aagcgaatca 300
gccttggtgc cctacatcga tgagccgctg gtagtggtta cagagcatgc tattaccaac 360
ttcaccaaag ctgagatggc acttgaattc aatcgtgagt tccttgacaa gatgcgtgtg 420
ctgtcagtgt caccaaaata ttcggatctt ctgacctatg ttgactgcta cgtcggtgtg 480
tctgctcgtc aggctttaaa caattttcag aaacaagtgc ctgtgattac acctactagg 540
cagacgatgt atgtcgactc gatacaagcg gccttgaaag ctttagaaaa gtgggagatt 600
gatctgagag tggctcaaac gttgctgcct acgaacgttc cgattggaga agtctcttgt 660
ccaatgcagt cggtagtgaa actgctggat gatcagctgc cagatgacag cctgatacgg 720
aggtatccca aggaagccgc cgtcgctttg gctaaacgaa acgggggaat acaatggatg 780
gacgtatcag aaggcaccgt gatgaacgag gctgtcaacg ctgttgcagc tagtgcactg 840
gcaccttcag catcagcccc acccttagaa gagaagtcaa agttaaccga acaagcgatg 900
gatctcgtga ccgcggctga gcctgagata attgcctcac tcgcgccagt tcccgcaccc 960
gtgtttgcca taccacctaa accagcagat tataatgtgc gtactctgag gatcgacgag 1020
gccacttggc tgcgaatgat tccaaaatca atgaacacac cttttcaaat ccaggtgact 1080
gataacacag gaactaattg gcatctcaat ttgagggggg ggactcgtgt agtgaatctg 1140
gaccaaatcg ctccgatgcg gtttgtatta gatctagggg gaaagagtta taaagagacg 1200
agctgggatc caaacggcaa gaaggtcgga ttcatcgttt ttcaatcgaa gataccattc 1260
gaactttgga ctgctgcttc acagatcggt caagccacgg tggttaacta tgtccaacta 1320
tacgctgaag acagctcatt taccgcgcag tctatcattg ctactacctc tttggcttat 1380
aactatgagc ctgagcagtt gaataagact gaccctgaga tgaattatta tcttttggcg 1440
acctttatag actcagccgc tataacgcca acgaatatga cacagcctga tgtttgggat 1500
gccttgctga cgatgtcccc actatcagct ggcgaggtga cagtgaaggg tgcggtagtg 1560
agtgaagtag tccctgcaga cttgataggt agctacactc cagaatccct aaacgcctca 1620
cttccgaatg atgctgctag atgcatgatc gatagagctt cgaagatagc cgaagcaatc 1680
aagattgatg atgatgctgg accagatgaa tattccccaa actctgtacc aattcaaggt 1740
cagcttgcta tctcgcaact cgaaactgga tatggtgtgc gaatattcaa ccctaaaggg 1800
atcctttcta aaattgcatc tagggcaatg caggctttca ttggtgaccc gagcacaatc 1860
atcacgcagg cggcgccagt gttatcagac aagaataatt ggattgcatt ggcacaggga 1920
gtgaaaacta gtctgcgtac taaaagtcta tcagcgggag tgaagactgc agtgagtaag 1980
ctgagctcat ctgagtctat ccagaattgg actcaaggat tcttggataa agtgtcagcg 2040
cattttccag caccaaagcc cgattgtccg actagcggag atagtggtga atcgtctaat 2100
cgccgagtga agcgcgactc atacgcagga gtggtcaaac gtgggtacac acgttaggcc 2160
gctcgccctg gtgacgcggg gttaagggat gcaggcaaat catc                  2204

<210> 7
<211> 2241
<212> DNA
<213> Reovirus

<400> 7
gctaaagtga ccgtggtcat ggcttcattc aagggattct ccgccaacac tgttccagtt 60
tctaaggcca agcgtgacat atcatctctt gccgctactc ctggacttcg ttcacaatcc 120
ttcactccgt ctgtggatat gtctcaatcg cgtgaattcc tcacaaaggc aattgagcaa 180
gggtccatgt ctatacctta tcagcatgtg aatgtaccga aagttgatcg taaagttgtt 240
agcctggtag tgcgaccttt ctcttcaggt gctttctcta tctctggagt gatttcgcca 300
gcccatgcct atctactaga gtgtctaccc cagcttgagc aggcgatggc ttttgttgct 360
tcacctgagt ctttccaggc ttccgacgtc gcgaagcgct ttgccataaa gccaggtatg 420
agcctccagg atgccatcac tgcctttatt aactttgtgt ccgcgatgct gaaaatgacg 480
gtgactcgtc aaaactttga cgttattgtg gctgagatcg agaggcttgc ttcaaccagc 540
gtgtccgtca ggactgaaga agcgaaggtt gctgatgagg agctaatgct attcgggtta 600
gatcatagag ggccacagca gctggatgtt tctgacgcta aagggataat gaaggctgct 660
gatattcaga caactcatga tgtccatttg gcaccaggcg ttggtaatat tgatcctgaa 720
atctataacg aggggcggtt catgttcatg cagcacaagc cacttgcggc ggatcaatcg 780
tatttcacct tggagactgc ggattatttc aagatttatc caacatacga tgaacatgat 840
ggcaggatgg ctgaccaaaa gcagtcggga ttgatactgt gtactaagga cgaggtattg 900
gctgagcaaa ctatatttaa actggacgcc cctgatgaca agactgttca tctgttggat 960
cgcgatgacg accacgttgt tgccagattt actaaggtat ttatagagga cgtggctccc 1020
gggcatcatg ctgctcaaag atcgggacaa cgctctgtgc ttgatgacct atatgcgaat 1080
acgcaagtga tttccattac ttctgctgct ttaaagtggg tggtcaagca cggcgtatct 1140
gatggaatcg tgaacaggaa gaatgtcaaa gtgtgtgttg gttttgaccc cctgtacacc 1200
ttgtctacac ataacggggt gtccttatgt gccctgctga tggacgaaaa actctctgtg 1260
ctgaacagtg cgtgtcgtat gacgttacgc tcactcatga agaccggacg cgacgttgat 1320
gcacacagag cttttcagcg agtcctctct caaggataca catcgctaat gtgctactat 1380
catccttcac ggaagttggc atatggtgag gtgctctttc tagaacgatc caatgacgtg 1440
acagatggga tcaagcttca gttggacgca tctagacagt gtcatgaatg tcctgtgttg 1500
cagcagaaag tggttgagtt agagaaacag attattatgc agaagtcaat ccagtcagac 1560
cctaccccag tggcgctgca accattgttg tctcagttgc gtgagttgtc tagtgaagtt 1620
actaggctac agatggagtt gagtcgagct cagtccctga atgctcagtt ggaggcggat 1680
gtcaagtcag ctcaatcatg tagcttggat atgtatctga gacaccacac ttgcattaat 1740
ggtcatgcta aagaagatga attgcttgac gctgtgcgtg tcgcgccgga tgtgaggaga 1800
gaaatcatgg aaaagaggag tgaagtgaga caaggttggt gcgaacgtat ttctaaggaa 1860
gcagctgcca aatgtcaaac tgttattgat gacctgactt tgatgaatgg aaagcaagca 1920
caagagataa cagaattacg tgattcggct gaaaaatatg agaaacagat tgcagagctg 1980
gtgagtacca tcacccaaaa ccagataacg tatcagcaag agctacaagc cttggtagcg 2040
aaaaatgtgg aattggacgc gttgaatcag cgtcaggcta agtctttgcg tattactccc 2100
tctcttctat cagccactcc tatcgattca gttgatgatg ttgctgactt aattgatttc 2160
tctgttccaa ctgatgagtt gtaaataatc cgtgatgcag tgttgcccta atcccttaag 2220
ccttcccgac ccccattcat c                                           2241

<210> 8
<211> 3854
<212> DNA
<213> Reovirus

<400> 8
gctacacgtt ccacgacaat gtcatccatg atactgactc agtttggacc gttcattgag 60
agcatttcag gtatcactga tcaatcgaat gacgtgtttg aagatgcagc aaaagcattc 120
tctatgttta ctcgcagcga tgtctacaag gcgctggatg aaataccttt ctctgatgat 180
gcgatgcttc caatccctcc aactatatat acgaaaccat ctcacgattc atattattac 240
attgatgctc taaaccgtgt gcgtcgcaaa acatatcagg gccctgatga cgtgtacgta 300
cctaattgtt ctattgttga attgctggag ccacatgaga ctctgacatc ttatgggcgg 360
ttgtccgagg ccatcgagaa tcgtgccaag gatggggaca gccaagccag aatcgccaca 420
acgtatggta gaatcgctga atctcaagct cgacagatta aggctccatt ggagaagttt 480
gtgttggcac tattagtggc cgaagcaggg gggtctttat atgatccagt tttgcagaag 540
tatgatgaga ttccagatct atcgcataat tgccctttat ggtgttttag agagatctgt 600
cgtcacatat ctggtccatt accagatcgg gcaccttatc tttacttatc tgcaggggtt 660
ttctggttaa tgtcaccacg aatgacgtct gcaatccctc cgctactatc cgatcttgtt 720
aatttagcta ttttgcaaca aactgcgggt ttagatccat cattagtgaa attgggagta 780
cagatatgcc ttcatgcagc agctagctca agttatgcat ggtttatctt aaagactaag 840
tctatttttc ctcaaaacac gttgcacagt atgtatgaat ctctagaagg gggatactgt 900
cctaatcttg aatggttaga gcctagatca gactataagt tcatgtacat gggagtcatg 960
ccattgtccg ctaagtatgc taggtcggcg ccgtccaatg ataagaaagc gcgggaactt 1020
ggcgagaaat atggactgag ctcagtcgtc ggtgagcttc gtaaacggac aaagacgtat 1080
gttaaacatg actttgcttc agtgaggtac attcgtgacg ctatggcatg tactagcggt 1140
attttcttgg taagaacacc caccgaaacg gtattgcaag aatatacgca gagtccggag 1200
attaaggttc ccattcccca gaaagactgg acaggcccaa taggtgaaat cagaattcta 1260
aaagatacaa caagttccat cgcgcgttac ttatatagaa catggtactt ggcagcggcg 1320
agaatggcgg ctcaaccacg tacgtgggat ccattgtttc aagcgattat gagatctcaa 1380
tacgtgacag ctaggggtgg atctggcgca gcactccgcg aatctttgta tgcaatcaat 1440
gtgtcgttac ctgatttcaa gggcttacca gtgaaggcag caactaagat attccaggcg 1500
gcacaattag cgaacttgcc gttctcccac acatcagtgg ctatactagc tgacacttca 1560
atgggattgc gaaatcaggt gcagaggcgg ccacgatcca ttatgccatt aaatgtgccc 1620
cagcagcagg tttcggcgcc ccatacattg acagcggatt acattaacta ccacatgaat 1680
ctatcaacca cgtctggtag tgcggtcatt gagaaggtga ttcctttagg tgtatacgct 1740
tcgagccctc ctaaccagtc gatcaacatt gacatatctg cgtgtgacgc tagtattact 1800
tgggatttct ttctgtcagt gattatggcg gctatacacg aaggtgtcgc tagtagctcc 1860
attggaaaac catttatggg ggttcctgca tccattgtaa atgatgagtc tgtcgttgga 1920
gtgagagctg ctaggccgat atcgggaatg cagaacatga ttcagcatct atcgaaacta 1980
tataaacgtg gattttcata tagagtaaac gattcttttt ctccaggtaa cgattttact 2040
catatgacta ccactttccc gtcaggttca acagccacct ctactgagca tactgctaat 2100
aatagtacga tgatggaaac tttcctgaca gtatggggac ccgaacatac tgacgaccct 2160
gacgtcttac gtttaatgaa gtctttaact attcaaagga attacgtatg tcaaggtgat 2220
gatggattaa tgattatcga tgggactact gctggtaagg tgaacagtga aactattcag 2280
aagatgctag aattaatctc aaaatatggt gaggaattcg gatggaaata tgacatagcg 2340
tacgatggga ctgccgaata cttaaagcta tacttcatat ttggctgtcg aattccaaat 2400
cttagtcgcc atccaatcgt ggggaaagaa cgggcgaatt cttcagcaga ggagccatgg 2460
ccagcaattc tagatcagat tatgggtgtc ttctttaatg gtgttcatga tgggttacag 2520
tggcagcggt ggatacgtta ttcatgggct ctatgctgtg ctttctcacg tcaaagaaca 2580
atgattggtg agagcgtggg ttaccttcaa tatcctatgt ggtcttttgt ctactgggga 2640
ttaccactgg ttaaagcgtt tgggtcagac ccatggatat tttcttggta catgcctact 2700
ggagatctgg gaatgtatag ttggattagc ttgatacgcc ctctgatgac aagatggatg 2760
gtggctaatg gttacgtaac tgacagatgc tcacccgtat tcgggaacgc agattatcgc 2820
aggtgtttca atgaacttaa actatatcaa ggttattata tggcacaatt gcccaggaat 2880
cctaagaagt ctggacgagc ggcccctcgg gaggtaagag aacaattcac tcaggcatta 2940
tccgactatc tactgcaaaa tccagagctg aagtcacgtg tgctacgtgg tcgtagtgag 3000
tgggagaaat atggagcggg gataattcac aatcctccgt cattattcga tgtgccccat 3060
aaatggtatc agggtgcgca agaggcagca atcgctacga gagaagagct ggcagaaatg 3120
gatgagacat taatgcgcgc tcgaaggcac agatattcga gcttttcaaa gttattagag 3180
gcgtatctgc tcgtgaaatg gcgaatgtgc gaggcccgcg aaccgtcggt ggatttgcga 3240
ttaccattat gtgcgggtat tgacccatta aactcagatc cttttctcaa gatggtaagc 3300
gttggaccaa tgctccagag tacgagaaag tactttgctc agacactatt catggcaaag 3360
acggtgtcgg gtcttgacgt taacgcgatt gatagcgcgt tattacgact gcgaacatta 3420
ggtgctgata agaaagcatt aacggcgcag ttattaatgg tggggcttca ggagtcagaa 3480
gcggacgcat tggccgggaa gataatgcta caggatgtga atactgtgca attagccaga 3540
gtggttaact tagctgtgcc agatacttgg atgtcgttag actttgactc tatgttcaaa 3600
caccacgtca agctgcttcc caaagatgga cgtcatctaa atactgatat tcctcctcga 3660
atgggatggt tacgggccat tttacgattc ttaggtgccg gaatggtaat gactgcgact 3720
ggagttgctg tcgacatcta tctggaggat atacatggcg gtggtcggtc acttggacag 3780
agattcatga cttggatgcg acaggaagga cggtcagcgt gagtctacca tgggtcgtgg 3840
tgcgtcaact catc                                                   3854

<210> 9
<211> 3916
<212> DNA
<213> Reovirus

<400> 9
gctaaatggc gcgatggcga acgtttgggg ggtgagactt gcagactcgt tatcttcacc 60
cactattgag acacgaacgc gtcagtatac cttacacgat ctttgctcag acctagatgc 120
taatccgggg agggaaccgt ggaaacctct gcgtaatcag cgtactaata atattgtggc 180
tgtgcaatta ttcagaccat tgcagggttt agttttagat acccagcttt atggatttcc 240
aggagcattt gatgactggg agcgattcat gagagagaag ctgcgtgtgc taaagtatga 300
agtattgcgc atctatccaa tcagcaacta tagcaatgaa catgtcaacg tcttcgtggc 360
caatgctttg gtgggcgctt tcctgtcgaa tcaagctttc tatgacctgc taccgttgtt 420
gataattaat gacactatga ttggtgatct acttggcacg ggggcatcgc tatcacagtt 480
ctttcaatct catggagatg tgctggaagt cgcagctggt cgtaagtatc tgcagatgga 540
aaactactcc aacgatgacg atgatcctcc attatttgcg aaagacctgt cagattatgc 600
taaagcattc tacagtgaca catatgaagt gttggacagg ttcttttgga cgcatgactc 660
ttcagcgggg gtcttagtgc attatgataa gccaacgaat ggtcatcact atctgctggg 720
tactttgact cagatggtca gtgcacctcc ttatattatt aacgctactg acgcaatgtt 780
gcttgaatcc tgtctagaac agttctcagc taatgtgcgt gcgagacctg cgcaacccgt 840
tacacgctta gaccaatgct atcatttaag atggggagca caatatgtag gagaagattc 900
actgacatat cggttggggg tgttatcctt gctggctacc aatggatatc aattagctag 960
accgattcca agacagttga cgaatcgatg gttgtcgagc tttgtgagtc aaattatgtc 1020
tgacggcgtc aacgagactc cactgtggcc ccaagaaagg tatgtgcaga tcgcttatga 1080
ttcaccatcc gttgttgatg gggctacgca atatggctat gtcaggaaga atcaactcag 1140
actcggcatg agaatatcgg cgctgcaatc gctgagtgat acgccctcgc cggtacagtg 1200
gcttccacaa tacaccatcg accaggcagc gatggacgaa ggcgatctga tggttagtcg 1260
gcttacgcaa ctcccgttac gtcctgatta tggtaatatc tgggtcggcg atgcgctatc 1320
ctattatgtg gactacaatc ggagtcatcg agtcgtgctt tcatcggaac ttcctcagct 1380
tccggacaca tattttgatg gcgatgaaca gtatgggcgc agcctgttct cactagctcg 1440
taagattggt gaccgctcgt tagtgaaaga tacggctgtc ttgaagcacg cttaccaagc 1500
catcgatcca aatactggta aggagtatct gagatctcgg caatctgtcg catattttgg 1560
tgcatcagcg ggtcattctg gtgccgacca gccgttagtc atagagccct ggattcaagg 1620
gaaaatcagt ggtgtgccgc caccctcctc agtgcgacag ttcggctatg atgttgcccg 1680
tggcgcgatc gtcgatctgg cgagaccatt tccttctgga gattatcaat ttgtctattc 1740
ggatgttgac caggtggtcg atggccatga cgatctgagt atatcatctg gactggtgga 1800
gagccttttg tcttcatgca tgcacgccac agcacccggg ggctcatttg ttgttaagat 1860
aaattttccg actagacccg tatggcacta catcgaacag aagatcttgc ccaatattac 1920
gtcatacatg ttgatcaagc ctttcgtcac caacaacgtc gaattgttct tcgtcgcttt 1980
cggtgtgcat caacactcat cacttacttg gacatctgga gtgtacttct tcttggtgga 2040
ccatttttat cgttatgaga ctttatctac gatctcacga caattgccgt cttttgggta 2100
tgttgatgat gggtcttccg tgactggtat cgagacaatt agtattgaga accctggctt 2160
ctcgaatatg acccaggccg ctcgcattgg tatctcagga ttgtgtgcta atgtaggtaa 2220
cgcgcgtaag tccattgcca tttacgaatc tcatggggcc agagtattaa ctatcacatc 2280
aaggagatct ccggcatcag ctagaagaaa gtctaggttg cgatatttgc cattaataga 2340
ccctaggtcg ttagaggtac aggcgcgcac tattctgcca gctgatccag tgttatttga 2400
aaacgtgagc ggagcgtcac cccatgtttg tctgacaatg atgtacaact tcgaagtgtc 2460
gtcagcggta tatgatggag acgttgtgct agatcttggg acgggaccag aggctaaaat 2520
ccttgaactg atacccgcaa cctctccagt cacatgcgtg gacatacggc ctacagcgca 2580
gcctagtgga tgttggaacg ttcgtaccac gttccttgag ttagattatt tgagcgatgg 2640
atggatcact ggggtgcgtg gggacatagt tacttgtatg ttatctttgg gggccgctgc 2700
cgctggaaaa tcaatgactt ttgacgctgc gtttcagcaa ttaatcaaag tattatccaa 2760
gagtacggct aatgttgtgc tggtgcaggt taactgccct acagacgtgg tgaggagcat 2820
taagggctac ctagagatag attcgactaa caagaggtat aggttcccca aatttggtcg 2880
agacgagccg tactctgaca tggatgcgct ggagaaaata tgtcgtaccg cctggccaaa 2940
ctgctcaatt acctgggttc cattgtcata cgacttgcgg tggactagac tggcattatt 3000
agagtccacg acattgagta gcgcgtcgat tagaattgct gagctgatgt ataaatacat 3060
gcctattatg aggattgata ttcatggact acccatggaa aagcgaggta acttcatagt 3120
ggggcagaac tgctcattag taatccctgg ttttaatgcg caggatgtct ttaactgtta 3180
tttcaattcc gccctcgctt tctcgactga agatgtcaat gctgcgatga ttccccaagt 3240
gtctgcgcag tttgatgcga ctaagggtga gtggacgttg gatatggtct tctccgacgc 3300
aggaatctat accatgcagg ctctagtggg atctaatgct aatccagtct ctttgggttc 3360
ctttgtagtt gattctccag atgtagatat aactgacgct tggccagctc agttagactt 3420
tacgatcgcg ggaactgatg tcgatataac agttaatcct tattaccgtc tgatgacctt 3480
tgtaaggatc gatggacagt ggcagattgc caatccagac aaatttcaat tcttttcgtc 3540
ggcgtctggg acgttagtga tgaacgtcaa attagatatc gcagataaat atctactata 3600
ctatatacga gatgtccagt ctcgagatgt tggcttttac attcagcatc cacttcaact 3660
tttgaatacg atcacattgc caaccaacga ggaccttttt ctgagcgcac ctgacatgcg 3720
agagtgggca gttaaggaaa gcggtaacac gatatgtata ctcaatagtc aagggtttgt 3780
gctacctcaa gattgggatg tgttaacaga taccataagt tggtccccat cgatacccac 3840
atacattgtg ccaccgggtg attatacctt gactcctctg taactcactg tccctcgtga 3900
gcgcgcctaa ttcatc                                                 3916

<210> 10
<211> 3901
<212> DNA
<213> Reovirus

<400> 10
gctaatcgtc aggatgaagc ggattccaag gaagacaaag ggcaaatcca gcggaaaggg 60
caatgactca acagagagag cggacgatgg ctcgagccaa ttaagagaca agcaaaacaa 120
taaggctggc cccgccacta cggagcctgg cacatccaac cgagagcaat acaaagctcg 180
accaggtatt gcatctgtgc agagggccac tgaaagtgca gaaatgccca tgaagaataa 240
tgacgaaggg acgccagata agaaaggaaa tactaagggc gacctagtta atgagcatag 300
tgaggctaaa gacgaggcgg atgaagcgac gaagaagcag gcaaaggata cagacaaaag 360
taaagcgcaa gtcacatatt cagacactgg tatcaataat gctaatgaac tgtcaagatc 420
tgggaatgtg gataatgagg gtggaagtaa tcagaagccg atgtctacca gaatagctga 480
ggcaacgtct gctatagtgt cgaaacatcc tgcgcgtgtt gggctgccac ctaccgctag 540
cagtggtcat gggtatcagt gccatgtctg ttctgcagtc ctgtttagtc ctttagacct 600
agatgcccac gtcgcctcac atggtttgca tggtaacatg acattaacat cgagtgatat 660
ccagcgacat ataactgagt tcatcagctc atggcaaaat catcctattg ttcaagtttc 720
ggctgatgtc gaaaataaga aaactgctca attgcttcac gctgacactc ctcgactcgt 780
cacttgggat gctggtttgt gtacttcatt caaaatcgtc ccgattgtgc cagctcaggt 840
gccgcaggat gtactggcct atacgttttt cacctcttca tacgctatcc aatcaccgtt 900
tccagaggcg gcagtgtcta ggattgtggt gcatacgaga tgggcatcta atgttgactt 960
tgaccgagac tcgtctgtca tcatggcgcc acctacagaa aacaatatcc atttgtttaa 1020
acagttacta aatactgaaa ccctgtctgt aaggggggct aatccgctaa tgttcagggc 1080
gaatgtgttg catatgttgc tagagttcgt attagataac ttgtatctga acagacatac 1140
gggattctct caagaccaca cgccatttac tgagggtgct aatttgcgtt cacttcctgg 1200
ccccgatgct gagaaatggt actcgattat gtatccaacg cgcatgggaa cgccgaatgt 1260
atccaaaata tgtaatttcg tcgcctcttg tgtgcgaaat cgggttggac ggtttgatcg 1320
agcacagatg atgaacggag ctatgtcaga gtgggtggat gtcttcgaga cttcagacgc 1380
gctaaccgtc tccattcgag gtcgatggat ggctagacta gctcgcatga acataaatcc 1440
aacagagatc gaatgggcat tgactgaatg tgcacaagga tatgtgactg tcacaagtcc 1500
ttacgctcct agcgtaaata gattgatgcc ctatcgtatc tccaacgctg agcggcaaat 1560
atcacagata atcaggatca tgaacattgg caataacgcg acggtgatac aacctgttct 1620
gcaagatatt tcggtactcc ttcaacgcat atcaccactc caaatagatc caactattat 1680
ttccaacact atgtcaacag tctcggagtc tactactcag accctcagcc ccgcgtcctc 1740
aattttgggt aaactacgac caagcaactc agatttttct agttttagag tcgcgttggc 1800
tggatggctt tataatgggg ttgtgacgac ggtgattgat gatagttcat atccaaaaga 1860
cggcggcagc gtgacctcac ttgaaaatct gtgggatttc ttcatccttg cgcttgctct 1920
accactgaca actgacccct gtgcacctgt gaaagcattc atgaccctag ccaacatgat 1980
ggttggtttc gagacaatcc ctatggataa tcagatctat actcaatcga gacgcgcgag 2040
tgctttctca acgcctcaca cgtggccacg atgctttatg aacatccagt taatttctcc 2100
aatcgacgct cccatcttgc gacagtgggc tgaaattatt catagatact ggcctaaccc 2160
ttcacagatt cgttatggtg caccgaacgt tttcggctcg gcaaatttgt tcactccacc 2220
tgaggtgctg ttattgccaa tcgatcatca accagctaat gtaacaacgc caacgctgga 2280
cttcaccaat gagttaacta attggcgcgc tcgtgtctgt gagcttatga agaatctcgt 2340
tgataaccaa agatatcaac ctggatggac acaaagtcta gtctcgtcaa tgcgcggaac 2400
gctagacaaa ttgaagttga ttaaatcgat gacaccaatg tatctgcaac agctggctcc 2460
ggtagagtta gcagtgatag ctcccatgtt gccttttcca cctttccagg tgccatacgt 2520
ccgtctcgat cgtgacagag ttccaacaat ggttggagta acacgacatt cacgagatac 2580
tattactcag ccggcgctat cgctgtcgac aaccaatact actgttggcg tgccactagc 2640
tctagacgcg agggctatca ccgttgcgct gttgtcaggg aaatatccgc cggatttggt 2700
gacaaatgta tggtacgctg atgccattta cccaatgtat gcagacacgg aggtgttctc 2760
taatcttcag agagacatga ttacctgcga ggccgtgcag acattagtga ctctggtggc 2820
gcaaatatca gagacccagt atcctgtaga taggtatctt gattggatcc catcactgag 2880
agcatcggcg gcgacggcgg cgacatttgc tgagtgggtt aatacttcaa tgaagacggc 2940
gtttgatttg tctgatatgc tgttagagcc tctcctaagc ggtgatccga ggatgactca 3000
actagcgatt cagtatcagc agtacaatgg cagaacgttt aatatcatac ctgaaatgcc 3060
aggttcagta attgctgact gcgttcaatt aacagcagaa gtctttaatc acgaatataa 3120
cctgtttggg attgcgcggg gtgatatcat cattggccgt gttcagtcga cacatttgtg 3180
gtcaccgctg gctcctccac ctgacctggt gtttgatcgt gatacccctg gtgttcacat 3240
cttcggacga gattgccgta tatcgtttgg aatgaatggc gccgcgccaa tgattagaga 3300
tgagactgga ctgatggtgc cttttgaagg aaattggatt ttcccactgg cgctttggca 3360
aatgaataca cgatatttta atcaacagtt cgacgcgtgg attaagacag gagagttgcg 3420
aatccgcatt gagatgggcg cgtatccata tatgttgcat tactatgatc cacgtcagta 3480
cgctaatgca tggaatttaa catccgcctg gcttgaagaa attacgccga cgagcatccc 3540
atccgtgcct ttcatggtgc ccatttcaag tgatcatgac atttcctctg ccccagctgt 3600
ccaatatatc atttcaactg aatataatga tcggtctctg ttctgcacta actcatcatc 3660
tccccaaacc atcgctggac cagacaaaca cattccagtt gagagatata acattctgac 3720
caaccccgac gctccaccca cgcagataca actgcctgaa gtcgttgact tgtacaacgt 3780
cgtcacacgc tatgcgtatg agactccgcc tattaccgct gttgttatgg gtgttccttg 3840
atcctcatcc tcccaacagg tgctagagca ttgcgctcaa tgctagttgg gccgattcat 3900
c                                                                 3901

<210> 11
<211> 455
<212> PRT
<213> Reovirus

<400> 11
Met Asp Pro Arg Leu Arg Glu Glu Val Val Arg Leu Ile Ile Ala Leu
 1               5                  10                  15      
Thr Ser Asp Asn Gly Ala Ser Leu Ser Lys Gly Leu Glu Ser Arg Val
            20                  25                  30          
Ser Ala Leu Glu Lys Thr Ser Gln Ile His Ser Asp Thr Ile Leu Arg
        35                  40                  45              
Ile Thr Gln Gly Leu Asp Asp Ala Asn Lys Arg Ile Ile Ala Leu Glu
    50                  55                  60                  
Gln Ser Arg Asp Asp Leu Val Ala Ser Val Ser Asp Ala Gln Leu Ala
65                  70                  75                  80  
Ile Ser Arg Leu Glu Ser Ser Ile Gly Ala Leu Gln Thr Val Val Asn
                85                  90                  95      
Gly Leu Asp Ser Ser Val Thr Gln Leu Gly Ala Arg Val Gly Gln Leu
            100                 105                 110         
Glu Thr Gly Leu Ala Glu Leu Arg Val Asp His Asp Asn Leu Val Ala
        115                 120                 125             
Arg Val Asp Thr Ala Glu Arg Asn Ile Gly Ser Leu Thr Thr Glu Leu
    130                 135                 140                 
Ser Thr Leu Thr Leu Arg Val Thr Ser Ile Gln Ala Asp Phe Glu Ser
145                 150                 155                 160 
Arg Ile Ser Thr Leu Glu Arg Thr Ala Val Thr Ser Ala Gly Ala Pro
                165                 170                 175     
Leu Ser Ile Arg Asn Asn Arg Met Thr Met Gly Leu Asn Asp Gly Leu
            180                 185                 190         
Thr Leu Ser Gly Asn Asn Leu Ala Ile Arg Leu Pro Gly Asn Thr Gly
        195                 200                 205             
Leu Asn Ile Gln Asn Gly Gly Leu Gln Phe Arg Phe Asn Thr Asp Gln
    210                 215                 220                 
Phe Gln Ile Val Asn Asn Asn Leu Thr Leu Lys Thr Thr Val Phe Asp
225                 230                 235                 240 
Ser Ile Asn Ser Arg Ile Gly Ala Thr Glu Gln Ser Tyr Val Ala Ser
                245                 250                 255     
Ala Val Thr Pro Leu Arg Leu Asn Ser Ser Thr Lys Val Leu Asp Met
            260                 265                 270         
Leu Ile Asp Ser Ser Thr Leu Glu Ile Asn Ser Ser Gly Gln Leu Thr
        275                 280                 285             
Val Arg Ser Thr Ser Pro Asn Leu Arg Tyr Pro Ile Ala Asp Val Ser
    290                 295                 300                 
Gly Gly Ile Gly Met Ser Pro Asn Tyr Arg Phe Arg Gln Ser Met Trp
305                 310                 315                 320 
Ile Gly Ile Val Ser Tyr Ser Gly Ser Gly Leu Asn Trp Arg Val Gln
                325                 330                 335     
Val Asn Ser Asp Ile Phe Ile Val Asp Asp Tyr Ile His Ile Cys Leu
            340                 345                 350         
Pro Ala Phe Asp Gly Phe Ser Ile Ala Asp Gly Gly Asp Leu Ser Leu
        355                 360                 365             
Asn Phe Val Thr Gly Leu Leu Pro Pro Leu Leu Thr Gly Asp Thr Glu
    370                 375                 380                 
Pro Ala Phe His Asn Asp Val Val Thr Tyr Gly Ala Gln Thr Val Ala
385                 390                 395                 400 
Ile Gly Leu Ser Ser Gly Gly Ala Pro Gln Tyr Met Ser Lys Asn Leu
                405                 410                 415     
Trp Val Glu Gln Trp Gln Asp Gly Val Leu Arg Leu Arg Val Glu Gly
            420                 425                 430         
Gly Gly Ser Ile Thr His Ser Asn Ser Lys Trp Pro Ala Met Thr Val
        435                 440                 445             
Ser Tyr Pro Arg Ser Phe Thr
    450                 455 


<210> 12
<211> 418
<212> PRT
<213> Reovirus

<400> 12
Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly Leu
 1               5                  10                  15      
Gln Asn Val Pro Ile Asn Asp Glu Leu Ser Ser His Leu Leu Arg Ala
            20                  25                  30          
Gly Asn Ser Pro Trp Gln Leu Thr Gln Phe Leu Asp Trp Ile Ser Leu
        35                  40                  45              
Gly Arg Gly Leu Ala Thr Ser Ala Leu Val Pro Thr Ala Gly Ser Arg
    50                  55                  60                  
Tyr Tyr Gln Met Ser Cys Leu Leu Ser Gly Thr Leu Gln Ile Pro Phe
65                  70                  75                  80  
Arg Pro Asn His Arg Trp Gly Asp Ile Arg Phe Leu Arg Leu Val Trp
                85                  90                  95      
Ser Ala Pro Thr Leu Asp Gly Leu Val Val Ala Pro Pro Gln Val Leu
            100                 105                 110         
Ala Gln Pro Ala Leu Gln Ala Gln Ala Asp Arg Val Tyr Asp Cys Asp
        115                 120                 125             
Asp Tyr Pro Phe Leu Ala Arg Asp Pro Arg Phe Lys His Arg Val Tyr
    130                 135                 140                 
Gln Gln Leu Ser Ala Val Thr Leu Leu Asn Leu Thr Gly Phe Gly Pro
145                 150                 155                 160 
Ile Ser Tyr Val Arg Val Asp Glu Asp Met Trp Ser Gly Asp Val Asn
                165                 170                 175     
Gln Leu Leu Met Asn Tyr Phe Gly His Thr Phe Ala Glu Ile Ala Tyr
            180                 185                 190         
Thr Leu Cys Gln Ala Ser Ala Asn Arg Pro Trp Glu Tyr Asp Gly Thr
        195                 200                 205             
Tyr Ala Arg Met Thr Gln Ile Val Leu Ser Leu Phe Trp Leu Ser Tyr
    210                 215                 220                 
Val Gly Val Ile His Gln Gln Asn Thr Tyr Arg Thr Phe Tyr Phe Gln
225                 230                 235                 240 
Cys Asn Arg Arg Gly Asp Ala Ala Glu Val Trp Ile Leu Ser Cys Ser
                245                 250                 255     
Leu Asn His Ser Ala Gln Ile Arg Pro Gly Asn Arg Ser Leu Phe Val
            260                 265                 270         
Met Pro Thr Ser Pro Asp Trp Asn Met Asp Val Asn Leu Ile Leu Ser
        275                 280                 285             
Ser Thr Leu Thr Gly Cys Leu Cys Ser Gly Ser Gln Leu Pro Leu Ile
    290                 295                 300                 
Asp Asn Asn Ser Val Pro Ala Val Ser Arg Asn Ile His Gly Trp Thr
305                 310                 315                 320 
Gly Arg Ala Gly Asn Gln Leu His Gly Phe Gln Val Arg Arg Met Val
                325                 330                 335     
Thr Glu Phe Cys Asp Arg Leu Arg Arg Asp Gly Val Met Thr Gln Ala
            340                 345                 350         
Gln Gln Asn Gln Val Glu Ala Leu Ala Asp Gln Thr Gln Gln Phe Lys
        355                 360                 365             
Arg Asp Lys Leu Glu Thr Trp Ala Arg Glu Asp Asp Gln Tyr Asn Gln
    370                 375                 380                 
Ala His Pro Asn Ser Thr Met Phe Arg Thr Lys Pro Phe Thr Asn Ala
385                 390                 395                 400 
Gln Trp Gly Arg Gly Asn Thr Gly Ala Thr Ser Ala Ala Ile Ala Ala
                405                 410                 415     
Leu Ile
        


<210> 13
<211> 254
<212> PRT
<213> Reovirus

<400> 13
Met Ala Ser Ser Leu Arg Ala Ala Ile Ser Lys Ile Lys Arg Asp Asp
 1               5                  10                  15      
Val Gly Gln Gln Val Cys Pro Asn Tyr Val Met Leu Arg Ser Ser Val
            20                  25                  30          
Thr Thr Lys Val Val Arg Asn Val Val Glu Tyr Gln Ile Arg Thr Gly
        35                  40                  45              
Gly Phe Phe Ser Cys Leu Ala Met Leu Arg Pro Leu Gln Tyr Ala Lys
    50                  55                  60                  
Arg Glu Arg Leu Leu Gly Gln Arg Asn Leu Glu Arg Ile Ser Thr Arg
65                  70                  75                  80  
Asp Ile Leu Gln Thr Arg Asp Leu His Ser Leu Cys Met Pro Thr Pro
                85                  90                  95      
Asp Ala Pro Met Ser Asn His Gln Ala Ser Thr Met Arg Glu Leu Ile
            100                 105                 110         
Cys Ser Tyr Phe Lys Val Asp His Ala Asp Gly Leu Lys Tyr Ile Pro
        115                 120                 125             
Met Asp Glu Arg Tyr Ser Pro Ser Ser Leu Ala Arg Leu Phe Thr Met
    130                 135                 140                 
Gly Met Ala Gly Leu His Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val
145                 150                 155                 160 
Pro Ile Met His Leu Ala Ala Asp Leu Asp Cys Met Thr Leu Ala Leu
                165                 170                 175     
Pro Tyr Met Ile Thr Leu Asp Gly Asp Thr Val Val Pro Val Ala Pro
            180                 185                 190         
Thr Leu Ser Ala Glu Gln Leu Leu Asp Asp Gly Leu Lys Gly Leu Ala
        195                 200                 205             
Cys Met Asp Met Asp Val Arg Trp Thr Arg Ile Ala Gly Arg Leu Val
    210                 215                 220                 
Ile Arg Val Trp Thr Leu His Ala Ala Ser Thr Ser Cys Ile Ala Arg
225                 230                 235                 240 
Arg Gln Gln Lys Pro Ser Val Cys Leu Arg His Ala Leu Cys
                245                 250                 


<210> 14
<211> 366
<212> PRT
<213> Reovirus

<400> 14
Met Ala Ser Ser Leu Arg Ala Ala Ile Ser Lys Ile Lys Arg Asp Asp
 1               5                  10                  15      
Val Gly Gln Gln Val Cys Pro Asn Tyr Val Met Leu Arg Ser Ser Val
            20                  25                  30          
Thr Thr Lys Val Val Arg Asn Val Val Glu Tyr Gln Ile Arg Thr Gly
        35                  40                  45              
Gly Phe Phe Ser Cys Leu Ala Met Leu Arg Pro Leu Gln Tyr Ala Lys
    50                  55                  60                  
Arg Glu Arg Leu Leu Gly Gln Arg Asn Leu Glu Arg Ile Ser Thr Arg
65                  70                  75                  80  
Asp Ile Leu Gln Thr Arg Asp Leu His Ser Leu Cys Met Pro Thr Pro
                85                  90                  95      
Asp Ala Pro Met Ser Asn His Gln Ala Ser Thr Met Arg Glu Leu Ile
            100                 105                 110         
Cys Ser Tyr Phe Lys Val Asp His Ala Asp Gly Leu Lys Tyr Ile Pro
        115                 120                 125             
Met Asp Glu Arg Tyr Ser Pro Ser Ser Leu Ala Arg Leu Phe Thr Met
    130                 135                 140                 
Gly Met Ala Gly Leu His Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val
145                 150                 155                 160 
Pro Ile Met His Leu Ala Ala Asp Leu Asp Cys Met Thr Leu Ala Leu
                165                 170                 175     
Pro Tyr Met Ile Thr Leu Asp Gly Asp Thr Val Val Pro Val Ala Pro
            180                 185                 190         
Thr Leu Ser Ala Glu Gln Leu Leu Asp Asp Gly Leu Lys Gly Leu Ala
        195                 200                 205             
Cys Met Asp Ile Ser Tyr Gly Cys Glu Val Asp Ala Asn Ser Arg Pro
    210                 215                 220                 
Ala Gly Asp Gln Ser Met Asp Ser Ser Arg Cys Ile Asn Glu Leu Tyr
225                 230                 235                 240 
Cys Glu Glu Thr Ala Glu Ala Ile Cys Val Leu Lys Thr Cys Leu Val
                245                 250                 255     
Leu Asn Cys Met Gln Phe Lys Leu Glu Met Asp Asp Leu Ala His Asn
            260                 265                 270         
Ala Ala Glu Leu Asp Lys Ile Gln Met Met Ile Pro Phe Ser Glu Arg
        275                 280                 285             
Val Phe Arg Met Ala Ser Ser Phe Ala Thr Ile Asp Ala Gln Cys Phe
    290                 295                 300                 
Arg Phe Cys Val Met Met Lys Asp Lys Asn Leu Lys Ile Asp Met Arg
305                 310                 315                 320 
Glu Thr Thr Arg Leu Trp Thr Arg Ser Ala Ser Asp Asp Ser Val Ala
                325                 330                 335     
Thr Ser Ser Leu Ser Ile Ser Leu Asp Arg Gly Arg Trp Val Ala Ala
            340                 345                 350         
Asp Ala Ser Asp Ala Arg Leu Leu Val Phe Pro Ile Arg Val
        355                 360                 365     


<210> 15
<211> 365
<212> PRT
<213> Reovirus

<400> 15
Met Glu Val Cys Leu Pro Asn Gly His Gln Val Val Asp Leu Ile Asn
 1               5                  10                  15      
Asn Ala Phe Glu Gly Arg Val Ser Ile Tyr Ser Ala Gln Glu Gly Trp
            20                  25                  30          
Asp Lys Thr Ile Ser Ala Gln Pro Asp Met Met Val Cys Gly Gly Ala
        35                  40                  45              
Val Val Cys Met His Cys Leu Gly Val Val Gly Ser Leu Gln Arg Lys
    50                  55                  60                  
Leu Lys His Leu Pro His His Arg Cys Asn Gln Gln Ile Arg His Gln
65                  70                  75                  80  
Asp Tyr Val Asp Val Gln Phe Ala Asp Arg Val Thr Ala His Trp Lys
                85                  90                  95      
Arg Gly Met Leu Ser Phe Val Ala Gln Met His Glu Met Met Asn Asp
            100                 105                 110         
Val Ser Pro Asp Asp Leu Asp Arg Val Arg Thr Glu Gly Gly Ser Leu
        115                 120                 125             
Val Glu Leu Asn Arg Leu Gln Val Asp Pro Asn Ser Met Phe Arg Ser
    130                 135                 140                 
Ile His Ser Ser Trp Thr Asp Pro Leu Gln Val Val Asp Asp Leu Asp
145                 150                 155                 160 
Thr Lys Leu Asp Gln Tyr Trp Thr Ala Leu Asn Leu Met Ile Asp Ser
                165                 170                 175     
Ser Asp Leu Ile Pro Asn Phe Met Met Arg Asp Pro Ser His Ala Phe
            180                 185                 190         
Asn Gly Val Lys Leu Lys Gly Asp Ala Arg Gln Thr Gln Phe Ser Arg
        195                 200                 205             
Thr Phe Asp Ser Arg Ser Ser Leu Glu Trp Gly Val Met Val Tyr Asp
    210                 215                 220                 
Tyr Ser Glu Leu Asp His Asp Pro Ser Lys Gly Arg Ala Tyr Arg Lys
225                 230                 235                 240 
Glu Leu Val Thr Pro Ala Arg Asp Phe Gly His Phe Gly Leu Ser His
                245                 250                 255     
Tyr Ser Arg Ala Thr Thr Pro Ile Leu Gly Lys Met Pro Ala Val Phe
            260                 265                 270         
Ser Gly Met Leu Thr Gly Asn Cys Lys Met Tyr Pro Phe Ile Lys Gly
        275                 280                 285             
Thr Ala Lys Leu Lys Thr Val Arg Lys Leu Val Glu Ala Val Asn His
    290                 295                 300                 
Ala Trp Gly Val Glu Lys Ile Arg Tyr Ala Leu Gly Pro Gly Gly Met
305                 310                 315                 320 
Thr Gly Trp Tyr Asn Arg Thr Met Gln Gln Ala Pro Ile Val Leu Thr
                325                 330                 335     
Pro Ala Ala Leu Thr Met Phe Pro Asp Thr Ile Lys Phe Gly Asp Leu
            340                 345                 350         
Asn Tyr Pro Val Met Ile Gly Asp Pro Met Ile Leu Gly
        355                 360                 365 


<210> 16
<211> 736
<212> PRT
<213> Reovirus

<400> 16
Met Ala Tyr Ile Ala Val Pro Ala Val Val Asp Ser Arg Ser Ser Glu
 1               5                  10                  15      
Ala Ile Gly Leu Leu Glu Ser Phe Gly Val Asp Ala Gly Ala Asp Ala
            20                  25                  30          
Asn Asp Val Ser Tyr Gln Asp His Asp Tyr Val Leu Asp Gln Leu Gln
        35                  40                  45              
Tyr Met Leu Asp Gly Tyr Glu Ala Gly Asp Val Ile Asp Ala Leu Val
    50                  55                  60                  
His Lys Asn Trp Leu His His Ser Val Tyr Cys Leu Leu Pro Pro Lys
65                  70                  75                  80  
Ser Gln Leu Leu Glu Tyr Trp Lys Ser Asn Pro Ser Ala Ile Pro Asp
                85                  90                  95      
Asn Val Asp Arg Arg Leu Arg Lys Arg Leu Met Leu Lys Lys Asp Leu
            100                 105                 110         
Arg Lys Asp Asp Glu Tyr Asn Gln Leu Ala Arg Ala Phe Lys Ile Ser
        115                 120                 125             
Asp Val Tyr Ala Pro Leu Ile Ser Ser Thr Thr Ser Pro Met Thr Met
    130                 135                 140                 
Ile Gln Asn Leu Asn Arg Gly Glu Ile Val Tyr Thr Thr Thr Asp Arg
145                 150                 155                 160 
Val Ile Gly Ala Arg Ile Leu Leu Tyr Ala Pro Arg Lys Tyr Tyr Ala
                165                 170                 175     
Ser Thr Leu Ser Phe Thr Met Thr Lys Cys Ile Ile Pro Phe Gly Lys
            180                 185                 190         
Glu Val Gly Arg Val Pro His Ser Arg Phe Asn Val Gly Thr Phe Pro
        195                 200                 205             
Ser Ile Ala Thr Pro Lys Cys Phe Val Met Ser Gly Val Asp Ile Glu
    210                 215                 220                 
Ser Ile Pro Asn Glu Phe Ile Lys Leu Phe Tyr Gln Arg Val Lys Ser
225                 230                 235                 240 
Val His Ala Asn Ile Leu Asn Asp Ile Ser Pro Gln Ile Val Ser Asp
                245                 250                 255     
Met Ile Asn Arg Lys Arg Leu Arg Val His Thr Pro Ser Asp Arg Arg
            260                 265                 270         
Ala Ala Gln Leu Met His Leu Pro Tyr His Val Lys Arg Gly Ala Ser
        275                 280                 285             
His Val Asp Val Tyr Lys Val Asp Val Val Asp Met Leu Phe Glu Val
    290                 295                 300                 
Val Asp Val Ala Asp Gly Leu Arg Asn Val Ser Arg Lys Leu Thr Met
305                 310                 315                 320 
His Thr Val Pro Val Cys Ile Leu Glu Met Leu Gly Ile Glu Ile Ala
                325                 330                 335     
Asp Tyr Cys Ile Arg Gln Glu Asp Gly Met Leu Thr Asp Trp Phe Leu
            340                 345                 350         
Leu Leu Thr Met Leu Ser Asp Gly Leu Thr Asp Arg Arg Thr His Cys
        355                 360                 365             
Gln Tyr Leu Ile Asn Pro Ser Ser Val Pro Pro Asp Val Ile Leu Asn
    370                 375                 380                 
Ile Ser Ile Thr Gly Phe Ile Asn Arg His Thr Ile Asp Val Met Pro
385                 390                 395                 400 
Asp Ile Tyr Asp Phe Val Lys Pro Ile Gly Ala Val Leu Pro Lys Gly
                405                 410                 415     
Ser Phe Lys Ser Thr Ile Met Arg Val Leu Asp Ser Ile Ser Ile Leu
            420                 425                 430         
Gly Ile Gln Ile Met Pro Arg Ala His Val Val Asp Ser Asp Glu Val
        435                 440                 445             
Gly Glu Gln Met Glu Pro Thr Phe Glu Gln Ala Val Met Glu Ile Tyr
    450                 455                 460                 
Lys Gly Ile Ala Gly Val Asp Ser Leu Asp Asp Leu Ile Lys Trp Val
465                 470                 475                 480 
Leu Asn Ser Asp Leu Ile Pro His Asp Asp Arg Leu Gly Gln Leu Phe
                485                 490                 495     
Gln Ala Phe Leu Pro Leu Ala Lys Asp Leu Leu Ala Pro Met Ala Arg
            500                 505                 510         
Lys Phe Tyr Asp Asn Ser Met Ser Glu Gly Arg Leu Leu Thr Phe Ser
        515                 520                 525             
His Ala Asp Ser Glu Leu Leu Asn Ala Asn Tyr Phe Gly His Leu Leu
    530                 535                 540                 
Arg Leu Lys Ile Pro Tyr Ile Thr Glu Val Asn Leu Met Ile Arg Lys
545                 550                 555                 560 
Asn Arg Glu Gly Gly Glu Leu Phe Gln Leu Val Leu Ser Tyr Leu Tyr
                565                 570                 575     
Lys Met Tyr Ala Thr Ser Ala Gln Pro Lys Trp Phe Gly Ser Leu Leu
            580                 585                 590         
Arg Leu Leu Ile Cys Pro Trp Leu His Met Glu Lys Leu Ile Gly Glu
        595                 600                 605             
Ala Asp Pro Ala Ser Thr Ser Ala Glu Ile Gly Trp His Ile Pro Arg
    610                 615                 620                 
Glu Gln Leu Met Gln Asp Gly Trp Cys Gly Cys Glu Asp Gly Phe Ile
625                 630                 635                 640 
Pro Tyr Val Ser Ile Arg Ala Pro Arg Leu Val Ile Glu Glu Leu Met
                645                 650                 655     
Glu Lys Asn Trp Gly Gln Tyr His Ala Gln Val Ile Val Thr Asp Gln
            660                 665                 670         
Leu Val Val Gly Glu Pro Arg Arg Val Ser Ala Lys Ala Val Ile Lys
        675                 680                 685             
Gly Asn His Leu Pro Val Lys Leu Val Ser Arg Phe Ala Cys Phe Thr
    690                 695                 700                 
Leu Thr Ala Lys Tyr Glu Met Arg Leu Ser Cys Gly His Ser Thr Gly
705                 710                 715                 720 
Arg Gly Ala Ala Tyr Ser Ala Arg Leu Ala Phe Arg Ser Asp Leu Ala
                725                 730                 735     


<210> 17
<211> 708
<212> PRT
<213> Reovirus

<400> 17
Met Gly Asn Ala Ser Ser Ile Val Gln Thr Ile Asn Val Thr Gly Asp
 1               5                  10                  15      
Gly Asn Val Phe Lys Pro Ser Ala Glu Thr Ser Ser Thr Ala Val Pro
            20                  25                  30          
Ser Leu Ser Leu Ser Pro Gly Met Leu Asn Pro Gly Gly Val Pro Trp
        35                  40                  45              
Ile Ala Val Gly Asp Glu Thr Ser Val Thr Ser Pro Gly Ala Leu Arg
    50                  55                  60                  
Arg Met Thr Ser Lys Asp Ile Pro Asp Thr Ala Ile Ile Asn Thr Asp
65                  70                  75                  80  
Asn Ser Ser Gly Ala Val Pro Ser Glu Ser Ala Leu Val Pro Tyr Ile
                85                  90                  95      
Asp Glu Pro Leu Val Val Val Thr Glu His Ala Ile Thr Asn Phe Thr
            100                 105                 110         
Lys Ala Glu Met Ala Leu Glu Phe Asn Arg Glu Phe Leu Asp Lys Met
        115                 120                 125             
Arg Val Leu Ser Val Ser Pro Lys Tyr Ser Asp Leu Leu Thr Tyr Val
    130                 135                 140                 
Asp Cys Tyr Val Gly Val Ser Ala Arg Gln Ala Leu Asn Asn Phe Gln
145                 150                 155                 160 
Lys Gln Val Pro Val Ile Thr Pro Thr Arg Gln Thr Met Tyr Val Asp
                165                 170                 175     
Ser Ile Gln Ala Ala Leu Lys Ala Leu Glu Lys Trp Glu Ile Asp Leu
            180                 185                 190         
Arg Val Ala Gln Thr Leu Leu Pro Thr Asn Val Pro Ile Gly Glu Val
        195                 200                 205             
Ser Cys Pro Met Gln Ser Val Val Lys Leu Leu Asp Asp Gln Leu Pro
    210                 215                 220                 
Asp Asp Ser Leu Ile Arg Arg Tyr Pro Lys Glu Ala Ala Val Ala Leu
225                 230                 235                 240 
Ala Lys Arg Asn Gly Gly Ile Gln Trp Met Asp Val Ser Glu Gly Thr
                245                 250                 255     
Val Met Asn Glu Ala Val Asn Ala Val Ala Ala Ser Ala Leu Ala Pro
            260                 265                 270         
Ser Ala Ser Ala Pro Pro Leu Glu Glu Lys Ser Lys Leu Thr Glu Gln
        275                 280                 285             
Ala Met Asp Leu Val Thr Ala Ala Glu Pro Glu Ile Ile Ala Ser Leu
    290                 295                 300                 
Ala Pro Val Pro Ala Pro Val Phe Ala Ile Pro Pro Lys Pro Ala Asp
305                 310                 315                 320 
Tyr Asn Val Arg Thr Leu Arg Ile Asp Glu Ala Thr Trp Leu Arg Met
                325                 330                 335     
Ile Pro Lys Ser Met Asn Thr Pro Phe Gln Ile Gln Val Thr Asp Asn
            340                 345                 350         
Thr Gly Thr Asn Trp His Leu Asn Leu Arg Gly Gly Thr Arg Val Val
        355                 360                 365             
Asn Leu Asp Gln Ile Ala Pro Met Arg Phe Val Leu Asp Leu Gly Gly
    370                 375                 380                 
Lys Ser Tyr Lys Glu Thr Ser Trp Asp Pro Asn Gly Lys Lys Val Gly
385                 390                 395                 400 
Phe Ile Val Phe Gln Ser Lys Ile Pro Phe Glu Leu Trp Thr Ala Ala
                405                 410                 415     
Ser Gln Ile Gly Gln Ala Thr Val Val Asn Tyr Val Gln Leu Tyr Ala
            420                 425                 430         
Glu Asp Ser Ser Phe Thr Ala Gln Ser Ile Ile Ala Thr Thr Ser Leu
        435                 440                 445             
Ala Tyr Asn Tyr Glu Pro Glu Gln Leu Asn Lys Thr Asp Pro Glu Met
    450                 455                 460                 
Asn Tyr Tyr Leu Leu Ala Thr Phe Ile Asp Ser Ala Ala Ile Thr Pro
465                 470                 475                 480 
Thr Asn Met Thr Gln Pro Asp Val Trp Asp Ala Leu Leu Thr Met Ser
                485                 490                 495     
Pro Leu Ser Ala Gly Glu Val Thr Val Lys Gly Ala Val Val Ser Glu
            500                 505                 510         
Val Val Pro Ala Asp Leu Ile Gly Ser Tyr Thr Pro Glu Ser Leu Asn
        515                 520                 525             
Ala Ser Leu Pro Asn Asp Ala Ala Arg Cys Met Ile Asp Arg Ala Ser
    530                 535                 540                 
Lys Ile Ala Glu Ala Ile Lys Ile Asp Asp Asp Ala Gly Pro Asp Glu
545                 550                 555                 560 
Tyr Ser Pro Asn Ser Val Pro Ile Gln Gly Gln Leu Ala Ile Ser Gln
                565                 570                 575     
Leu Glu Thr Gly Tyr Gly Val Arg Ile Phe Asn Pro Lys Gly Ile Leu
            580                 585                 590         
Ser Lys Ile Ala Ser Arg Ala Met Gln Ala Phe Ile Gly Asp Pro Ser
        595                 600                 605             
Thr Ile Ile Thr Gln Ala Ala Pro Val Leu Ser Asp Lys Asn Asn Trp
    610                 615                 620                 
Ile Ala Leu Ala Gln Gly Val Lys Thr Ser Leu Arg Thr Lys Ser Leu
625                 630                 635                 640 
Ser Ala Gly Val Lys Thr Ala Val Ser Lys Leu Ser Ser Ser Glu Ser
                645                 650                 655     
Ile Gln Asn Trp Thr Gln Gly Phe Leu Asp Lys Val Ser Ala His Phe
            660                 665                 670         
Pro Ala Pro Lys Pro Asp Cys Pro Thr Ser Gly Asp Ser Gly Glu Ser
        675                 680                 685             
Ser Asn Arg Arg Val Lys Arg Asp Ser Tyr Ala Gly Val Val Lys Arg
    690                 695                 700                 
Gly Tyr Thr Arg
705             


<210> 18
<211> 721
<212> PRT
<213> Reovirus

<400> 18
Met Ala Ser Phe Lys Gly Phe Ser Ala Asn Thr Val Pro Val Ser Lys
 1               5                  10                  15      
Ala Lys Arg Asp Ile Ser Ser Leu Ala Ala Thr Pro Gly Leu Arg Ser
            20                  25                  30          
Gln Ser Phe Thr Pro Ser Val Asp Met Ser Gln Ser Arg Glu Phe Leu
        35                  40                  45              
Thr Lys Ala Ile Glu Gln Gly Ser Met Ser Ile Pro Tyr Gln His Val
    50                  55                  60                  
Asn Val Pro Lys Val Asp Arg Lys Val Val Ser Leu Val Val Arg Pro
65                  70                  75                  80  
Phe Ser Ser Gly Ala Phe Ser Ile Ser Gly Val Ile Ser Pro Ala His
                85                  90                  95      
Ala Tyr Leu Leu Glu Cys Leu Pro Gln Leu Glu Gln Ala Met Ala Phe
            100                 105                 110         
Val Ala Ser Pro Glu Ser Phe Gln Ala Ser Asp Val Ala Lys Arg Phe
        115                 120                 125             
Ala Ile Lys Pro Gly Met Ser Leu Gln Asp Ala Ile Thr Ala Phe Ile
    130                 135                 140                 
Asn Phe Val Ser Ala Met Leu Lys Met Thr Val Thr Arg Gln Asn Phe
145                 150                 155                 160 
Asp Val Ile Val Ala Glu Ile Glu Arg Leu Ala Ser Thr Ser Val Ser
                165                 170                 175     
Val Arg Thr Glu Glu Ala Lys Val Ala Asp Glu Glu Leu Met Leu Phe
            180                 185                 190         
Gly Leu Asp His Arg Gly Pro Gln Gln Leu Asp Val Ser Asp Ala Lys
        195                 200                 205             
Gly Ile Met Lys Ala Ala Asp Ile Gln Thr Thr His Asp Val His Leu
    210                 215                 220                 
Ala Pro Gly Val Gly Asn Ile Asp Pro Glu Ile Tyr Asn Glu Gly Arg
225                 230                 235                 240 
Phe Met Phe Met Gln His Lys Pro Leu Ala Ala Asp Gln Ser Tyr Phe
                245                 250                 255     
Thr Leu Glu Thr Ala Asp Tyr Phe Lys Ile Tyr Pro Thr Tyr Asp Glu
            260                 265                 270         
His Asp Gly Arg Met Ala Asp Gln Lys Gln Ser Gly Leu Ile Leu Cys
        275                 280                 285             
Thr Lys Asp Glu Val Leu Ala Glu Gln Thr Ile Phe Lys Leu Asp Ala
    290                 295                 300                 
Pro Asp Asp Lys Thr Val His Leu Leu Asp Arg Asp Asp Asp His Val
305                 310                 315                 320 
Val Ala Arg Phe Thr Lys Val Phe Ile Glu Asp Val Ala Pro Gly His
                325                 330                 335     
His Ala Ala Gln Arg Ser Gly Gln Arg Ser Val Leu Asp Asp Leu Tyr
            340                 345                 350         
Ala Asn Thr Gln Val Ile Ser Ile Thr Ser Ala Ala Leu Lys Trp Val
        355                 360                 365             
Val Lys His Gly Val Ser Asp Gly Ile Val Asn Arg Lys Asn Val Lys
    370                 375                 380                 
Val Cys Val Gly Phe Asp Pro Leu Tyr Thr Leu Ser Thr His Asn Gly
385                 390                 395                 400 
Val Ser Leu Cys Ala Leu Leu Met Asp Glu Lys Leu Ser Val Leu Asn
                405                 410                 415     
Ser Ala Cys Arg Met Thr Leu Arg Ser Leu Met Lys Thr Gly Arg Asp
            420                 425                 430         
Val Asp Ala His Arg Ala Phe Gln Arg Val Leu Ser Gln Gly Tyr Thr
        435                 440                 445             
Ser Leu Met Cys Tyr Tyr His Pro Ser Arg Lys Leu Ala Tyr Gly Glu
    450                 455                 460                 
Val Leu Phe Leu Glu Arg Ser Asn Asp Val Thr Asp Gly Ile Lys Leu
465                 470                 475                 480 
Gln Leu Asp Ala Ser Arg Gln Cys His Glu Cys Pro Val Leu Gln Gln
                485                 490                 495     
Lys Val Val Glu Leu Glu Lys Gln Ile Ile Met Gln Lys Ser Ile Gln
            500                 505                 510         
Ser Asp Pro Thr Pro Val Ala Leu Gln Pro Leu Leu Ser Gln Leu Arg
        515                 520                 525             
Glu Leu Ser Ser Glu Val Thr Arg Leu Gln Met Glu Leu Ser Arg Ala
    530                 535                 540                 
Gln Ser Leu Asn Ala Gln Leu Glu Ala Asp Val Lys Ser Ala Gln Ser
545                 550                 555                 560 
Cys Ser Leu Asp Met Tyr Leu Arg His His Thr Cys Ile Asn Gly His
                565                 570                 575     
Ala Lys Glu Asp Glu Leu Leu Asp Ala Val Arg Val Ala Pro Asp Val
            580                 585                 590         
Arg Arg Glu Ile Met Glu Lys Arg Ser Glu Val Arg Gln Gly Trp Cys
        595                 600                 605             
Glu Arg Ile Ser Lys Glu Ala Ala Ala Lys Cys Gln Thr Val Ile Asp
    610                 615                 620                 
Asp Leu Thr Leu Met Asn Gly Lys Gln Ala Gln Glu Ile Thr Glu Leu
625                 630                 635                 640 
Arg Asp Ser Ala Glu Lys Tyr Glu Lys Gln Ile Ala Glu Leu Val Ser
                645                 650                 655     
Thr Ile Thr Gln Asn Gln Ile Thr Tyr Gln Gln Glu Leu Gln Ala Leu
            660                 665                 670         
Val Ala Lys Asn Val Glu Leu Asp Ala Leu Asn Gln Arg Gln Ala Lys
        675                 680                 685             
Ser Leu Arg Ile Thr Pro Ser Leu Leu Ser Ala Thr Pro Ile Asp Ser
    690                 695                 700                 
Val Asp Asp Val Ala Asp Leu Ile Asp Phe Ser Val Pro Thr Asp Glu
705                 710                 715                 720 
Leu
    


<210> 19
<211> 1267
<212> PRT
<213> Reovirus

<400> 19
Met Ser Ser Met Ile Leu Thr Gln Phe Gly Pro Phe Ile Glu Ser Ile
 1               5                  10                  15      
Ser Gly Ile Thr Asp Gln Ser Asn Asp Val Phe Glu Asp Ala Ala Lys
            20                  25                  30          
Ala Phe Ser Met Phe Thr Arg Ser Asp Val Tyr Lys Ala Leu Asp Glu
        35                  40                  45              
Ile Pro Phe Ser Asp Asp Ala Met Leu Pro Ile Pro Pro Thr Ile Tyr
    50                  55                  60                  
Thr Lys Pro Ser His Asp Ser Tyr Tyr Tyr Ile Asp Ala Leu Asn Arg
65                  70                  75                  80  
Val Arg Arg Lys Thr Tyr Gln Gly Pro Asp Asp Val Tyr Val Pro Asn
                85                  90                  95      
Cys Ser Ile Val Glu Leu Leu Glu Pro His Glu Thr Leu Thr Ser Tyr
            100                 105                 110         
Gly Arg Leu Ser Glu Ala Ile Glu Asn Arg Ala Lys Asp Gly Asp Ser
        115                 120                 125             
Gln Ala Arg Ile Ala Thr Thr Tyr Gly Arg Ile Ala Glu Ser Gln Ala
    130                 135                 140                 
Arg Gln Ile Lys Ala Pro Leu Glu Lys Phe Val Leu Ala Leu Leu Val
145                 150                 155                 160 
Ala Glu Ala Gly Gly Ser Leu Tyr Asp Pro Val Leu Gln Lys Tyr Asp
                165                 170                 175     
Glu Ile Pro Asp Leu Ser His Asn Cys Pro Leu Trp Cys Phe Arg Glu
            180                 185                 190         
Ile Cys Arg His Ile Ser Gly Pro Leu Pro Asp Arg Ala Pro Tyr Leu
        195                 200                 205             
Tyr Leu Ser Ala Gly Val Phe Trp Leu Met Ser Pro Arg Met Thr Ser
    210                 215                 220                 
Ala Ile Pro Pro Leu Leu Ser Asp Leu Val Asn Leu Ala Ile Leu Gln
225                 230                 235                 240 
Gln Thr Ala Gly Leu Asp Pro Ser Leu Val Lys Leu Gly Val Gln Ile
                245                 250                 255     
Cys Leu His Ala Ala Ala Ser Ser Ser Tyr Ala Trp Phe Ile Leu Lys
            260                 265                 270         
Thr Lys Ser Ile Phe Pro Gln Asn Thr Leu His Ser Met Tyr Glu Ser
        275                 280                 285             
Leu Glu Gly Gly Tyr Cys Pro Asn Leu Glu Trp Leu Glu Pro Arg Ser
    290                 295                 300                 
Asp Tyr Lys Phe Met Tyr Met Gly Val Met Pro Leu Ser Ala Lys Tyr
305                 310                 315                 320 
Ala Arg Ser Ala Pro Ser Asn Asp Lys Lys Ala Arg Glu Leu Gly Glu
                325                 330                 335     
Lys Tyr Gly Leu Ser Ser Val Val Gly Glu Leu Arg Lys Arg Thr Lys
            340                 345                 350         
Thr Tyr Val Lys His Asp Phe Ala Ser Val Arg Tyr Ile Arg Asp Ala
        355                 360                 365             
Met Ala Cys Thr Ser Gly Ile Phe Leu Val Arg Thr Pro Thr Glu Thr
    370                 375                 380                 
Val Leu Gln Glu Tyr Thr Gln Ser Pro Glu Ile Lys Val Pro Ile Pro
385                 390                 395                 400 
Gln Lys Asp Trp Thr Gly Pro Ile Gly Glu Ile Arg Ile Leu Lys Asp
                405                 410                 415     
Thr Thr Ser Ser Ile Ala Arg Tyr Leu Tyr Arg Thr Trp Tyr Leu Ala
            420                 425                 430         
Ala Ala Arg Met Ala Ala Gln Pro Arg Thr Trp Asp Pro Leu Phe Gln
        435                 440                 445             
Ala Ile Met Arg Ser Gln Tyr Val Thr Ala Arg Gly Gly Ser Gly Ala
    450                 455                 460                 
Ala Leu Arg Glu Ser Leu Tyr Ala Ile Asn Val Ser Leu Pro Asp Phe
465                 470                 475                 480 
Lys Gly Leu Pro Val Lys Ala Ala Thr Lys Ile Phe Gln Ala Ala Gln
                485                 490                 495     
Leu Ala Asn Leu Pro Phe Ser His Thr Ser Val Ala Ile Leu Ala Asp
            500                 505                 510         
Thr Ser Met Gly Leu Arg Asn Gln Val Gln Arg Arg Pro Arg Ser Ile
        515                 520                 525             
Met Pro Leu Asn Val Pro Gln Gln Gln Val Ser Ala Pro His Thr Leu
    530                 535                 540                 
Thr Ala Asp Tyr Ile Asn Tyr His Met Asn Leu Ser Thr Thr Ser Gly
545                 550                 555                 560 
Ser Ala Val Ile Glu Lys Val Ile Pro Leu Gly Val Tyr Ala Ser Ser
                565                 570                 575     
Pro Pro Asn Gln Ser Ile Asn Ile Asp Ile Ser Ala Cys Asp Ala Ser
            580                 585                 590         
Ile Thr Trp Asp Phe Phe Leu Ser Val Ile Met Ala Ala Ile His Glu
        595                 600                 605             
Gly Val Ala Ser Ser Ser Ile Gly Lys Pro Phe Met Gly Val Pro Ala
    610                 615                 620                 
Ser Ile Val Asn Asp Glu Ser Val Val Gly Val Arg Ala Ala Arg Pro
625                 630                 635                 640 
Ile Ser Gly Met Gln Asn Met Ile Gln His Leu Ser Lys Leu Tyr Lys
                645                 650                 655     
Arg Gly Phe Ser Tyr Arg Val Asn Asp Ser Phe Ser Pro Gly Asn Asp
            660                 665                 670         
Phe Thr His Met Thr Thr Thr Phe Pro Ser Gly Ser Thr Ala Thr Ser
        675                 680                 685             
Thr Glu His Thr Ala Asn Asn Ser Thr Met Met Glu Thr Phe Leu Thr
    690                 695                 700                 
Val Trp Gly Pro Glu His Thr Asp Asp Pro Asp Val Leu Arg Leu Met
705                 710                 715                 720 
Lys Ser Leu Thr Ile Gln Arg Asn Tyr Val Cys Gln Gly Asp Asp Gly
                725                 730                 735     
Leu Met Ile Ile Asp Gly Thr Thr Ala Gly Lys Val Asn Ser Glu Thr
            740                 745                 750         
Ile Gln Lys Met Leu Glu Leu Ile Ser Lys Tyr Gly Glu Glu Phe Gly
        755                 760                 765             
Trp Lys Tyr Asp Ile Ala Tyr Asp Gly Thr Ala Glu Tyr Leu Lys Leu
    770                 775                 780                 
Tyr Phe Ile Phe Gly Cys Arg Ile Pro Asn Leu Ser Arg His Pro Ile
785                 790                 795                 800 
Val Gly Lys Glu Arg Ala Asn Ser Ser Ala Glu Glu Pro Trp Pro Ala
                805                 810                 815     
Ile Leu Asp Gln Ile Met Gly Val Phe Phe Asn Gly Val His Asp Gly
            820                 825                 830         
Leu Gln Trp Gln Arg Trp Ile Arg Tyr Ser Trp Ala Leu Cys Cys Ala
        835                 840                 845             
Phe Ser Arg Gln Arg Thr Met Ile Gly Glu Ser Val Gly Tyr Leu Gln
    850                 855                 860                 
Tyr Pro Met Trp Ser Phe Val Tyr Trp Gly Leu Pro Leu Val Lys Ala
865                 870                 875                 880 
Phe Gly Ser Asp Pro Trp Ile Phe Ser Trp Tyr Met Pro Thr Gly Asp
                885                 890                 895     
Leu Gly Met Tyr Ser Trp Ile Ser Leu Ile Arg Pro Leu Met Thr Arg
            900                 905                 910         
Trp Met Val Ala Asn Gly Tyr Val Thr Asp Arg Cys Ser Pro Val Phe
        915                 920                 925             
Gly Asn Ala Asp Tyr Arg Arg Cys Phe Asn Glu Leu Lys Leu Tyr Gln
    930                 935                 940                 
Gly Tyr Tyr Met Ala Gln Leu Pro Arg Asn Pro Lys Lys Ser Gly Arg
945                 950                 955                 960 
Ala Ala Pro Arg Glu Val Arg Glu Gln Phe Thr Gln Ala Leu Ser Asp
                965                 970                 975     
Tyr Leu Leu Gln Asn Pro Glu Leu Lys Ser Arg Val Leu Arg Gly Arg
            980                 985                 990         
Ser Glu Trp Glu Lys Tyr Gly Ala Gly Ile Ile His Asn Pro Pro Ser
        995                 1000                1005            
Leu Phe Asp Val Pro His Lys Trp Tyr Gln Gly Ala Gln Glu Ala Ala
    1010                1015                1020                
Ile Ala Thr Arg Glu Glu Leu Ala Glu Met Asp Glu Thr Leu Met Arg
1025                1030                1035               1040 
Ala Arg Arg His Arg Tyr Ser Ser Phe Ser Lys Leu Leu Glu Ala Tyr
                1045                1050                1055    
Leu Leu Val Lys Trp Arg Met Cys Glu Ala Arg Glu Pro Ser Val Asp
            1060                1065                1070        
Leu Arg Leu Pro Leu Cys Ala Gly Ile Asp Pro Leu Asn Ser Asp Pro
        1075                1080                1085            
Phe Leu Lys Met Val Ser Val Gly Pro Met Leu Gln Ser Thr Arg Lys
    1090                1095                1100                
Tyr Phe Ala Gln Thr Leu Phe Met Ala Lys Thr Val Ser Gly Leu Asp
1105                1110                1115               1120 
Val Asn Ala Ile Asp Ser Ala Leu Leu Arg Leu Arg Thr Leu Gly Ala
                1125                1130                1135    
Asp Lys Lys Ala Leu Thr Ala Gln Leu Leu Met Val Gly Leu Gln Glu
            1140                1145                1150        
Ser Glu Ala Asp Ala Leu Ala Gly Lys Ile Met Leu Gln Asp Val Asn
        1155                1160                1165            
Thr Val Gln Leu Ala Arg Val Val Asn Leu Ala Val Pro Asp Thr Trp
    1170                1175                1180                
Met Ser Leu Asp Phe Asp Ser Met Phe Lys His His Val Lys Leu Leu
1185                1190                1195               1200 
Pro Lys Asp Gly Arg His Leu Asn Thr Asp Ile Pro Pro Arg Met Gly
                1205                1210                1215    
Trp Leu Arg Ala Ile Leu Arg Phe Leu Gly Ala Gly Met Val Met Thr
            1220                1225                1230        
Ala Thr Gly Val Ala Val Asp Ile Tyr Leu Glu Asp Ile His Gly Gly
        1235                1240                1245            
Gly Arg Ser Leu Gly Gln Arg Phe Met Thr Trp Met Arg Gln Glu Gly
    1250                1255                1260                
Arg Ser Ala
1265        


<210> 20
<211> 1289
<212> PRT
<213> Reovirus

<400> 20
Met Ala Asn Val Trp Gly Val Arg Leu Ala Asp Ser Leu Ser Ser Pro
 1               5                  10                  15      
Thr Ile Glu Thr Arg Thr Arg Gln Tyr Thr Leu His Asp Leu Cys Ser
            20                  25                  30          
Asp Leu Asp Ala Asn Pro Gly Arg Glu Pro Trp Lys Pro Leu Arg Asn
        35                  40                  45              
Gln Arg Thr Asn Asn Ile Val Ala Val Gln Leu Phe Arg Pro Leu Gln
    50                  55                  60                  
Gly Leu Val Leu Asp Thr Gln Leu Tyr Gly Phe Pro Gly Ala Phe Asp
65                  70                  75                  80  
Asp Trp Glu Arg Phe Met Arg Glu Lys Leu Arg Val Leu Lys Tyr Glu
                85                  90                  95      
Val Leu Arg Ile Tyr Pro Ile Ser Asn Tyr Ser Asn Glu His Val Asn
            100                 105                 110         
Val Phe Val Ala Asn Ala Leu Val Gly Ala Phe Leu Ser Asn Gln Ala
        115                 120                 125             
Phe Tyr Asp Leu Leu Pro Leu Leu Ile Ile Asn Asp Thr Met Ile Gly
    130                 135                 140                 
Asp Leu Leu Gly Thr Gly Ala Ser Leu Ser Gln Phe Phe Gln Ser His
145                 150                 155                 160 
Gly Asp Val Leu Glu Val Ala Ala Gly Arg Lys Tyr Leu Gln Met Glu
                165                 170                 175     
Asn Tyr Ser Asn Asp Asp Asp Asp Pro Pro Leu Phe Ala Lys Asp Leu
            180                 185                 190         
Ser Asp Tyr Ala Lys Ala Phe Tyr Ser Asp Thr Tyr Glu Val Leu Asp
        195                 200                 205             
Arg Phe Phe Trp Thr His Asp Ser Ser Ala Gly Val Leu Val His Tyr
    210                 215                 220                 
Asp Lys Pro Thr Asn Gly His His Tyr Leu Leu Gly Thr Leu Thr Gln
225                 230                 235                 240 
Met Val Ser Ala Pro Pro Tyr Ile Ile Asn Ala Thr Asp Ala Met Leu
                245                 250                 255     
Leu Glu Ser Cys Leu Glu Gln Phe Ser Ala Asn Val Arg Ala Arg Pro
            260                 265                 270         
Ala Gln Pro Val Thr Arg Leu Asp Gln Cys Tyr His Leu Arg Trp Gly
        275                 280                 285             
Ala Gln Tyr Val Gly Glu Asp Ser Leu Thr Tyr Arg Leu Gly Val Leu
    290                 295                 300                 
Ser Leu Leu Ala Thr Asn Gly Tyr Gln Leu Ala Arg Pro Ile Pro Arg
305                 310                 315                 320 
Gln Leu Thr Asn Arg Trp Leu Ser Ser Phe Val Ser Gln Ile Met Ser
                325                 330                 335     
Asp Gly Val Asn Glu Thr Pro Leu Trp Pro Gln Glu Arg Tyr Val Gln
            340                 345                 350         
Ile Ala Tyr Asp Ser Pro Ser Val Val Asp Gly Ala Thr Gln Tyr Gly
        355                 360                 365             
Tyr Val Arg Lys Asn Gln Leu Arg Leu Gly Met Arg Ile Ser Ala Leu
    370                 375                 380                 
Gln Ser Leu Ser Asp Thr Pro Ser Pro Val Gln Trp Leu Pro Gln Tyr
385                 390                 395                 400 
Thr Ile Asp Gln Ala Ala Met Asp Glu Gly Asp Leu Met Val Ser Arg
                405                 410                 415     
Leu Thr Gln Leu Pro Leu Arg Pro Asp Tyr Gly Asn Ile Trp Val Gly
            420                 425                 430         
Asp Ala Leu Ser Tyr Tyr Val Asp Tyr Asn Arg Ser His Arg Val Val
        435                 440                 445             
Leu Ser Ser Glu Leu Pro Gln Leu Pro Asp Thr Tyr Phe Asp Gly Asp
    450                 455                 460                 
Glu Gln Tyr Gly Arg Ser Leu Phe Ser Leu Ala Arg Lys Ile Gly Asp
465                 470                 475                 480 
Arg Ser Leu Val Lys Asp Thr Ala Val Leu Lys His Ala Tyr Gln Ala
                485                 490                 495     
Ile Asp Pro Asn Thr Gly Lys Glu Tyr Leu Arg Ser Arg Gln Ser Val
            500                 505                 510         
Ala Tyr Phe Gly Ala Ser Ala Gly His Ser Gly Ala Asp Gln Pro Leu
        515                 520                 525             
Val Ile Glu Pro Trp Ile Gln Gly Lys Ile Ser Gly Val Pro Pro Pro
    530                 535                 540                 
Ser Ser Val Arg Gln Phe Gly Tyr Asp Val Ala Arg Gly Ala Ile Val
545                 550                 555                 560 
Asp Leu Ala Arg Pro Phe Pro Ser Gly Asp Tyr Gln Phe Val Tyr Ser
                565                 570                 575     
Asp Val Asp Gln Val Val Asp Gly His Asp Asp Leu Ser Ile Ser Ser
            580                 585                 590         
Gly Leu Val Glu Ser Leu Leu Ser Ser Cys Met His Ala Thr Ala Pro
        595                 600                 605             
Gly Gly Ser Phe Val Val Lys Ile Asn Phe Pro Thr Arg Pro Val Trp
    610                 615                 620                 
His Tyr Ile Glu Gln Lys Ile Leu Pro Asn Ile Thr Ser Tyr Met Leu
625                 630                 635                 640 
Ile Lys Pro Phe Val Thr Asn Asn Val Glu Leu Phe Phe Val Ala Phe
                645                 650                 655     
Gly Val His Gln His Ser Ser Leu Thr Trp Thr Ser Gly Val Tyr Phe
            660                 665                 670         
Phe Leu Val Asp His Phe Tyr Arg Tyr Glu Thr Leu Ser Thr Ile Ser
        675                 680                 685             
Arg Gln Leu Pro Ser Phe Gly Tyr Val Asp Asp Gly Ser Ser Val Thr
    690                 695                 700                 
Gly Ile Glu Thr Ile Ser Ile Glu Asn Pro Gly Phe Ser Asn Met Thr
705                 710                 715                 720 
Gln Ala Ala Arg Ile Gly Ile Ser Gly Leu Cys Ala Asn Val Gly Asn
                725                 730                 735     
Ala Arg Lys Ser Ile Ala Ile Tyr Glu Ser His Gly Ala Arg Val Leu
            740                 745                 750         
Thr Ile Thr Ser Arg Arg Ser Pro Ala Ser Ala Arg Arg Lys Ser Arg
        755                 760                 765             
Leu Arg Tyr Leu Pro Leu Ile Asp Pro Arg Ser Leu Glu Val Gln Ala
    770                 775                 780                 
Arg Thr Ile Leu Pro Ala Asp Pro Val Leu Phe Glu Asn Val Ser Gly
785                 790                 795                 800 
Ala Ser Pro His Val Cys Leu Thr Met Met Tyr Asn Phe Glu Val Ser
                805                 810                 815     
Ser Ala Val Tyr Asp Gly Asp Val Val Leu Asp Leu Gly Thr Gly Pro
            820                 825                 830         
Glu Ala Lys Ile Leu Glu Leu Ile Pro Ala Thr Ser Pro Val Thr Cys
        835                 840                 845             
Val Asp Ile Arg Pro Thr Ala Gln Pro Ser Gly Cys Trp Asn Val Arg
    850                 855                 860                 
Thr Thr Phe Leu Glu Leu Asp Tyr Leu Ser Asp Gly Trp Ile Thr Gly
865                 870                 875                 880 
Val Arg Gly Asp Ile Val Thr Cys Met Leu Ser Leu Gly Ala Ala Ala
                885                 890                 895     
Ala Gly Lys Ser Met Thr Phe Asp Ala Ala Phe Gln Gln Leu Ile Lys
            900                 905                 910         
Val Leu Ser Lys Ser Thr Ala Asn Val Val Leu Val Gln Val Asn Cys
        915                 920                 925             
Pro Thr Asp Val Val Arg Ser Ile Lys Gly Tyr Leu Glu Ile Asp Ser
    930                 935                 940                 
Thr Asn Lys Arg Tyr Arg Phe Pro Lys Phe Gly Arg Asp Glu Pro Tyr
945                 950                 955                 960 
Ser Asp Met Asp Ala Leu Glu Lys Ile Cys Arg Thr Ala Trp Pro Asn
                965                 970                 975     
Cys Ser Ile Thr Trp Val Pro Leu Ser Tyr Asp Leu Arg Trp Thr Arg
            980                 985                 990         
Leu Ala Leu Leu Glu Ser Thr Thr Leu Ser Ser Ala Ser Ile Arg Ile
        995                 1000                1005            
Ala Glu Leu Met Tyr Lys Tyr Met Pro Ile Met Arg Ile Asp Ile His
    1010                1015                1020                
Gly Leu Pro Met Glu Lys Arg Gly Asn Phe Ile Val Gly Gln Asn Cys
1025                1030                1035               1040 
Ser Leu Val Ile Pro Gly Phe Asn Ala Gln Asp Val Phe Asn Cys Tyr
                1045                1050                1055    
Phe Asn Ser Ala Leu Ala Phe Ser Thr Glu Asp Val Asn Ala Ala Met
            1060                1065                1070        
Ile Pro Gln Val Ser Ala Gln Phe Asp Ala Thr Lys Gly Glu Trp Thr
        1075                1080                1085            
Leu Asp Met Val Phe Ser Asp Ala Gly Ile Tyr Thr Met Gln Ala Leu
    1090                1095                1100                
Val Gly Ser Asn Ala Asn Pro Val Ser Leu Gly Ser Phe Val Val Asp
1105                1110                1115               1120 
Ser Pro Asp Val Asp Ile Thr Asp Ala Trp Pro Ala Gln Leu Asp Phe
                1125                1130                1135    
Thr Ile Ala Gly Thr Asp Val Asp Ile Thr Val Asn Pro Tyr Tyr Arg
            1140                1145                1150        
Leu Met Thr Phe Val Arg Ile Asp Gly Gln Trp Gln Ile Ala Asn Pro
        1155                1160                1165            
Asp Lys Phe Gln Phe Phe Ser Ser Ala Ser Gly Thr Leu Val Met Asn
    1170                1175                1180                
Val Lys Leu Asp Ile Ala Asp Lys Tyr Leu Leu Tyr Tyr Ile Arg Asp
1185                1190                1195               1200 
Val Gln Ser Arg Asp Val Gly Phe Tyr Ile Gln His Pro Leu Gln Leu
                1205                1210                1215    
Leu Asn Thr Ile Thr Leu Pro Thr Asn Glu Asp Leu Phe Leu Ser Ala
            1220                1225                1230        
Pro Asp Met Arg Glu Trp Ala Val Lys Glu Ser Gly Asn Thr Ile Cys
        1235                1240                1245            
Ile Leu Asn Ser Gln Gly Phe Val Leu Pro Gln Asp Trp Asp Val Leu
    1250                1255                1260                
Thr Asp Thr Ile Ser Trp Ser Pro Ser Ile Pro Thr Tyr Ile Val Pro
1265                1270                1275               1280 
Pro Gly Asp Tyr Thr Leu Thr Pro Leu
                1285                


<210> 21
<211> 1275
<212> PRT
<213> Reovirus

<400> 21
Met Lys Arg Ile Pro Arg Lys Thr Lys Gly Lys Ser Ser Gly Lys Gly
 1               5                  10                  15      
Asn Asp Ser Thr Glu Arg Ala Asp Asp Gly Ser Ser Gln Leu Arg Asp
            20                  25                  30          
Lys Gln Asn Asn Lys Ala Gly Pro Ala Thr Thr Glu Pro Gly Thr Ser
        35                  40                  45              
Asn Arg Glu Gln Tyr Lys Ala Arg Pro Gly Ile Ala Ser Val Gln Arg
    50                  55                  60                  
Ala Thr Glu Ser Ala Glu Met Pro Met Lys Asn Asn Asp Glu Gly Thr
65                  70                  75                  80  
Pro Asp Lys Lys Gly Asn Thr Lys Gly Asp Leu Val Asn Glu His Ser
                85                  90                  95      
Glu Ala Lys Asp Glu Ala Asp Glu Ala Thr Lys Lys Gln Ala Lys Asp
            100                 105                 110         
Thr Asp Lys Ser Lys Ala Gln Val Thr Tyr Ser Asp Thr Gly Ile Asn
        115                 120                 125             
Asn Ala Asn Glu Leu Ser Arg Ser Gly Asn Val Asp Asn Glu Gly Gly
    130                 135                 140                 
Ser Asn Gln Lys Pro Met Ser Thr Arg Ile Ala Glu Ala Thr Ser Ala
145                 150                 155                 160 
Ile Val Ser Lys His Pro Ala Arg Val Gly Leu Pro Pro Thr Ala Ser
                165                 170                 175     
Ser Gly His Gly Tyr Gln Cys His Val Cys Ser Ala Val Leu Phe Ser
            180                 185                 190         
Pro Leu Asp Leu Asp Ala His Val Ala Ser His Gly Leu His Gly Asn
        195                 200                 205             
Met Thr Leu Thr Ser Ser Asp Ile Gln Arg His Ile Thr Glu Phe Ile
    210                 215                 220                 
Ser Ser Trp Gln Asn His Pro Ile Val Gln Val Ser Ala Asp Val Glu
225                 230                 235                 240 
Asn Lys Lys Thr Ala Gln Leu Leu His Ala Asp Thr Pro Arg Leu Val
                245                 250                 255     
Thr Trp Asp Ala Gly Leu Cys Thr Ser Phe Lys Ile Val Pro Ile Val
            260                 265                 270         
Pro Ala Gln Val Pro Gln Asp Val Leu Ala Tyr Thr Phe Phe Thr Ser
        275                 280                 285             
Ser Tyr Ala Ile Gln Ser Pro Phe Pro Glu Ala Ala Val Ser Arg Ile
    290                 295                 300                 
Val Val His Thr Arg Trp Ala Ser Asn Val Asp Phe Asp Arg Asp Ser
305                 310                 315                 320 
Ser Val Ile Met Ala Pro Pro Thr Glu Asn Asn Ile His Leu Phe Lys
                325                 330                 335     
Gln Leu Leu Asn Thr Glu Thr Leu Ser Val Arg Gly Ala Asn Pro Leu
            340                 345                 350         
Met Phe Arg Ala Asn Val Leu His Met Leu Leu Glu Phe Val Leu Asp
        355                 360                 365             
Asn Leu Tyr Leu Asn Arg His Thr Gly Phe Ser Gln Asp His Thr Pro
    370                 375                 380                 
Phe Thr Glu Gly Ala Asn Leu Arg Ser Leu Pro Gly Pro Asp Ala Glu
385                 390                 395                 400 
Lys Trp Tyr Ser Ile Met Tyr Pro Thr Arg Met Gly Thr Pro Asn Val
                405                 410                 415     
Ser Lys Ile Cys Asn Phe Val Ala Ser Cys Val Arg Asn Arg Val Gly
            420                 425                 430         
Arg Phe Asp Arg Ala Gln Met Met Asn Gly Ala Met Ser Glu Trp Val
        435                 440                 445             
Asp Val Phe Glu Thr Ser Asp Ala Leu Thr Val Ser Ile Arg Gly Arg
    450                 455                 460                 
Trp Met Ala Arg Leu Ala Arg Met Asn Ile Asn Pro Thr Glu Ile Glu
465                 470                 475                 480 
Trp Ala Leu Thr Glu Cys Ala Gln Gly Tyr Val Thr Val Thr Ser Pro
                485                 490                 495     
Tyr Ala Pro Ser Val Asn Arg Leu Met Pro Tyr Arg Ile Ser Asn Ala
            500                 505                 510         
Glu Arg Gln Ile Ser Gln Ile Ile Arg Ile Met Asn Ile Gly Asn Asn
        515                 520                 525             
Ala Thr Val Ile Gln Pro Val Leu Gln Asp Ile Ser Val Leu Leu Gln
    530                 535                 540                 
Arg Ile Ser Pro Leu Gln Ile Asp Pro Thr Ile Ile Ser Asn Thr Met
545                 550                 555                 560 
Ser Thr Val Ser Glu Ser Thr Thr Gln Thr Leu Ser Pro Ala Ser Ser
                565                 570                 575     
Ile Leu Gly Lys Leu Arg Pro Ser Asn Ser Asp Phe Ser Ser Phe Arg
            580                 585                 590         
Val Ala Leu Ala Gly Trp Leu Tyr Asn Gly Val Val Thr Thr Val Ile
        595                 600                 605             
Asp Asp Ser Ser Tyr Pro Lys Asp Gly Gly Ser Val Thr Ser Leu Glu
    610                 615                 620                 
Asn Leu Trp Asp Phe Phe Ile Leu Ala Leu Ala Leu Pro Leu Thr Thr
625                 630                 635                 640 
Asp Pro Cys Ala Pro Val Lys Ala Phe Met Thr Leu Ala Asn Met Met
                645                 650                 655     
Val Gly Phe Glu Thr Ile Pro Met Asp Asn Gln Ile Tyr Thr Gln Ser
            660                 665                 670         
Arg Arg Ala Ser Ala Phe Ser Thr Pro His Thr Trp Pro Arg Cys Phe
        675                 680                 685             
Met Asn Ile Gln Leu Ile Ser Pro Ile Asp Ala Pro Ile Leu Arg Gln
    690                 695                 700                 
Trp Ala Glu Ile Ile His Arg Tyr Trp Pro Asn Pro Ser Gln Ile Arg
705                 710                 715                 720 
Tyr Gly Ala Pro Asn Val Phe Gly Ser Ala Asn Leu Phe Thr Pro Pro
                725                 730                 735     
Glu Val Leu Leu Leu Pro Ile Asp His Gln Pro Ala Asn Val Thr Thr
            740                 745                 750         
Pro Thr Leu Asp Phe Thr Asn Glu Leu Thr Asn Trp Arg Ala Arg Val
        755                 760                 765             
Cys Glu Leu Met Lys Asn Leu Val Asp Asn Gln Arg Tyr Gln Pro Gly
    770                 775                 780                 
Trp Thr Gln Ser Leu Val Ser Ser Met Arg Gly Thr Leu Asp Lys Leu
785                 790                 795                 800 
Lys Leu Ile Lys Ser Met Thr Pro Met Tyr Leu Gln Gln Leu Ala Pro
                805                 810                 815     
Val Glu Leu Ala Val Ile Ala Pro Met Leu Pro Phe Pro Pro Phe Gln
            820                 825                 830         
Val Pro Tyr Val Arg Leu Asp Arg Asp Arg Val Pro Thr Met Val Gly
        835                 840                 845             
Val Thr Arg His Ser Arg Asp Thr Ile Thr Gln Pro Ala Leu Ser Leu
    850                 855                 860                 
Ser Thr Thr Asn Thr Thr Val Gly Val Pro Leu Ala Leu Asp Ala Arg
865                 870                 875                 880 
Ala Ile Thr Val Ala Leu Leu Ser Gly Lys Tyr Pro Pro Asp Leu Val
                885                 890                 895     
Thr Asn Val Trp Tyr Ala Asp Ala Ile Tyr Pro Met Tyr Ala Asp Thr
            900                 905                 910         
Glu Val Phe Ser Asn Leu Gln Arg Asp Met Ile Thr Cys Glu Ala Val
        915                 920                 925             
Gln Thr Leu Val Thr Leu Val Ala Gln Ile Ser Glu Thr Gln Tyr Pro
    930                 935                 940                 
Val Asp Arg Tyr Leu Asp Trp Ile Pro Ser Leu Arg Ala Ser Ala Ala
945                 950                 955                 960 
Thr Ala Ala Thr Phe Ala Glu Trp Val Asn Thr Ser Met Lys Thr Ala
                965                 970                 975     
Phe Asp Leu Ser Asp Met Leu Leu Glu Pro Leu Leu Ser Gly Asp Pro
            980                 985                 990         
Arg Met Thr Gln Leu Ala Ile Gln Tyr Gln Gln Tyr Asn Gly Arg Thr
        995                 1000                1005            
Phe Asn Ile Ile Pro Glu Met Pro Gly Ser Val Ile Ala Asp Cys Val
    1010                1015                1020                
Gln Leu Thr Ala Glu Val Phe Asn His Glu Tyr Asn Leu Phe Gly Ile
1025                1030                1035               1040 
Ala Arg Gly Asp Ile Ile Ile Gly Arg Val Gln Ser Thr His Leu Trp
                1045                1050                1055    
Ser Pro Leu Ala Pro Pro Pro Asp Leu Val Phe Asp Arg Asp Thr Pro
            1060                1065                1070        
Gly Val His Ile Phe Gly Arg Asp Cys Arg Ile Ser Phe Gly Met Asn
        1075                1080                1085            
Gly Ala Ala Pro Met Ile Arg Asp Glu Thr Gly Leu Met Val Pro Phe
    1090                1095                1100                
Glu Gly Asn Trp Ile Phe Pro Leu Ala Leu Trp Gln Met Asn Thr Arg
1105                1110                1115               1120 
Tyr Phe Asn Gln Gln Phe Asp Ala Trp Ile Lys Thr Gly Glu Leu Arg
                1125                1130                1135    
Ile Arg Ile Glu Met Gly Ala Tyr Pro Tyr Met Leu His Tyr Tyr Asp
            1140                1145                1150        
Pro Arg Gln Tyr Ala Asn Ala Trp Asn Leu Thr Ser Ala Trp Leu Glu
        1155                1160                1165            
Glu Ile Thr Pro Thr Ser Ile Pro Ser Val Pro Phe Met Val Pro Ile
    1170                1175                1180                
Ser Ser Asp His Asp Ile Ser Ser Ala Pro Ala Val Gln Tyr Ile Ile
1185                1190                1195               1200 
Ser Thr Glu Tyr Asn Asp Arg Ser Leu Phe Cys Thr Asn Ser Ser Ser
                1205                1210                1215    
Pro Gln Thr Ile Ala Gly Pro Asp Lys His Ile Pro Val Glu Arg Tyr
            1220                1225                1230        
Asn Ile Leu Thr Asn Pro Asp Ala Pro Pro Thr Gln Ile Gln Leu Pro
        1235                1240                1245            
Glu Val Val Asp Leu Tyr Asn Val Val Thr Arg Tyr Ala Tyr Glu Thr
    1250                1255                1260                
Pro Pro Ile Thr Ala Val Val Met Gly Val Pro
1265                1270                1275

<210> 22
<211> 3854
<212> DNA
<213> Reovirus

<400> 22
gctacacgtt ccacgacaat gtcatccatg atactgactc agtttggacc gttcattgag 60
agcatttcag gtatcactga tcaatcgaat gacgtgtttg aagatgcagc aaaagcattc 120
tctatgttta ctcgcagcga tgtctacaag gcgctggatg aaataccttt ctctgatgat 180
gcgatgcttc caatccctcc aactatatat acgaaaccat ctcacgattc atattattac 240
attgatgctc taaaccgtgt gcgtcgcaaa acatatcagg gccctgatga cgtgtacgta 300
cctaattgtt ctattgttga attgctggag ccacatgaga ctctgacatc ttatgggcgg 360
ttgtccgagg ccatcgagaa tcgtgccaag gatggggaca gccaagccag aatcgccaca 420
acgtatggta gaatcgctga atctcaagct cgacagatta aggctccatt ggagaagttt 480
gtgttggcac tattagtggc cgaagcaggg gggtctttat atgatccagt tttgcagaag 540
tatgatgaga ttccagatct atcgcataat tgccctttat ggtgttttag agagatctgt 600
cgtcacatat ctggtccatt accagatcgg gcaccttatc tttacttatc tgcaggggta 660
ttctggttaa tgtcaccacg aatgacgtct gcaatccctc cgctactatc cgatcttgtt 720
aatttagcta ttttgcaaca aactgcgggt ttagatccat cattagtgaa attgggagta 780
cagatatgcc ttcatgcagc agctagctca agttattcat ggtttatctt aaagactaag 840
tctatttttc ctcaaaacac gttgcacagt atgtatgaat ctctagaagg gggatactgt 900
cctaatcttg aatggttaga gcctagatca gactataagt tcatgtacat gggagtcatg 960
ccattgtccg ctaagtatgc taggtcggcg ccgtccaatg ataagaaagc gcgggaactt 1020
ggcgagaaat atggactgag ctcagtcgtc ggtgagcttc gtaaacggac aaagacgtat 1080
gttaaacatg actttgcttc agtgaggtac attcgtgacg ctatggcatg tactagcggt 1140
attttcttgg taagaacacc caccgaaacg gtattgcaag aatatacgca gagtccggag 1200
attaaggttc ccattcccca gaaagactgg acaggcccaa taggtgaaat cagaattcta 1260
aaagatacaa caagttccat cgcgcgttac ttatatagaa catggtactt ggcagcggcg 1320
agaatggcgg ctcaaccacg tacgtgggat ccattgtttc aagcgattat gagatctcaa 1380
tacgtgacag ctaggggtgg atctggcgca gcactccgcg aatctttgta tgcaatcaat 1440
gtgtcgttac ctgatttcaa gggcttacca gtgaaggcag caactaagat attccaggcg 1500
gcacaattag cgaacttgcc gttctcccac acatcagtgg ctatactagc tgacacttca 1560
atgggattgc gaaatcaggt gcagaggcgg ccacgatcca ttatgccatt aaatgtgccc 1620
cagcagcagg tttcggcgcc ccatacattg acagcggatt acattaacta ccacatgaat 1680
ctatcaccca cgtctggtag tgcggtcatt gagaaggtga ttcctttagg tgtatacgct 1740
tcgagccctc ctaaccagtc gatcaacatt gacatatctg cgtgtgacgc tagtattact 1800
tgggatttct ttctgtcagt gattatggcg gctatacacg aaggtgtcgc tagtagctcc 1860
attggaaaac catttatggg ggttcctgca tccattgtaa atgatgagtc tgtcgttgga 1920
gtgagagctg ctaggccgat atcgggaatg cagaacatga ttcagcatct atcgaaacta 1980
tataaacgtg gattttcata tagagtaaac gattcttttt ctccaggtaa cgattttact 2040
catatgacta ccactttccc gtcaggttca acagccacct ctactgagca tactgctaat 2100
aatagtacga tgatggaaac tttcctgaca gtatggggac ccgaacatac tgacgaccct 2160
gacgtcttac gtttaatgaa gtctttaact attcaaagga attacgtatg tcaaggtgat 2220
gatggattaa tgattatcga tgggactact gctggtaagg tgaacagtga aactattcag 2280
aacgatctag aattaatctc aaaatatggt gaggaattcg gatggaaata tgacatagcg 2340
tacgatggga ctgccgaata cttaaagcta tacttcatat ttggctgtcg aattccaaat 2400
cttagtcgcc atccaatcgt ggggaaagaa cgggcgaatt cttcagcaga ggagccatgg 2460
ccagcaattc tagatcagat tatgggtgtc ttctttaatg gtgttcatga tgggttacag 2520
tggcagcggt ggatacgtta ttcatgggct ctatgctgtg ctttctcacg tcaaagaaca 2580
atgattggtg agagcgtggg ttaccttcaa tatcctatgt ggtcttttgt ctactgggga 2640
ttaccactgg ttaaagcgtt tgggtcagac ccatggatat tttcttggta catgcctact 2700
ggagatctgg gaatgtatag ttggattagc ttgatacgcc ctctgatgac aagatggatg 2760
gtggctaatg gttacgtaac tgacagatgc tcaaccgtat tcgggaacgc agattatcgc 2820
aggtgtttca atgaacttaa actatatcaa ggttattata tggcacaatt gcccaggaat 2880
cctaagaagt ctggacgagc ggcctctcgg gaggtaagag aacaattcac tcaggcatta 2940
tccgactatc taatgcaaaa tccagagctg aagtcacgtg tgctacgtgg tcgtagtgag 3000
tgggagaaat atggagcggg gataattcac aatcctccgt cattattcga tgtgccccat 3060
aaatggtatc agggtgcgca agaggcagca atcgctacga gagaagagct ggcagaaatg 3120
gatgagacat taatgcgcgc tcgaaggcac agctattcga gcttttcaaa gttattagag 3180
gcgtatctgc tcgtgaaatg gcgaatgtgc gaggcccgcg aaccgtcggt tgatttgcga 3240
ttaccattat gtgcgggtat tgacccatta aactcagatc cttttctcaa gatggtaagc 3300
gttggaccaa tgctccagag tacgagaaag tactttgctc agacactatt catggcaaag 3360
acggtgtcgg gtcttgacgt taacgcgatt gatagcgcgt tattacgact gcgaacatta 3420
ggtgctgata agaaagcatt aacggcgcag ttattaatgg tggggcttca ggagtcagaa 3480
gcggacgcat tggccgggaa gataatgcta caggatgtga atactgtgca attagccaga 3540
gtggttaact tagctgtgcc agatacttgg atgtcgttag actttgactc tatgttcaaa 3600
caccacgtca agctgcttcc caaagatgga cgtcatctaa atactgatat tcctcctcga 3660
atgggatggt tacgggccat tttacgattc ttaggtgccg gaatggtaat gactgcgact 3720
ggagttgctg tcgacatcta tctggaggat atacatggcg gtggtcggtc acttggacag 3780
agattcatga cttggatgcg acaggaagga cggtcagcgt gagtctacca tgggtcgtgg 3840
tgcgtcaact catc                                                   3854

<210> 23
<211> 1267
<212> PRT
<213> Reovirus

<400> 23
Met Ser Ser Met Ile Leu Thr Gln Phe Gly Pro Phe Ile Glu Ser Ile
 1               5                  10                  15      
Ser Gly Ile Thr Asp Gln Ser Asn Asp Val Phe Glu Asp Ala Ala Lys
            20                  25                  30          
Ala Phe Ser Met Phe Thr Arg Ser Asp Val Tyr Lys Ala Leu Asp Glu
        35                  40                  45              
Ile Pro Phe Ser Asp Asp Ala Met Leu Pro Ile Pro Pro Thr Ile Tyr
    50                  55                  60                  
Thr Lys Pro Ser His Asp Ser Tyr Tyr Tyr Ile Asp Ala Leu Asn Arg
65                  70                  75                  80  
Val Arg Arg Lys Thr Tyr Gln Gly Pro Asp Asp Val Tyr Val Pro Asn
                85                  90                  95      
Cys Ser Ile Val Glu Leu Leu Glu Pro His Glu Thr Leu Thr Ser Tyr
            100                 105                 110         
Gly Arg Leu Ser Glu Ala Ile Glu Asn Arg Ala Lys Asp Gly Asp Ser
        115                 120                 125             
Gln Ala Arg Ile Ala Thr Thr Tyr Gly Arg Ile Ala Glu Ser Gln Ala
    130                 135                 140                 
Arg Gln Ile Lys Ala Pro Leu Glu Lys Phe Val Leu Ala Leu Leu Val
145                 150                 155                 160 
Ala Glu Ala Gly Gly Ser Leu Tyr Asp Pro Val Leu Gln Lys Tyr Asp
                165                 170                 175     
Glu Ile Pro Asp Leu Ser His Asn Cys Pro Leu Trp Cys Phe Arg Glu
            180                 185                 190         
Ile Cys Arg His Ile Ser Gly Pro Leu Pro Asp Arg Ala Pro Tyr Leu
        195                 200                 205             
Tyr Leu Ser Ala Gly Val Phe Trp Leu Met Ser Pro Arg Met Thr Ser
    210                 215                 220                 
Ala Ile Pro Pro Leu Leu Ser Asp Leu Val Asn Leu Ala Ile Leu Gln
225                 230                 235                 240 
Gln Thr Ala Gly Leu Asp Pro Ser Leu Val Lys Leu Gly Val Gln Ile
                245                 250                 255     
Cys Leu His Ala Ala Ala Ser Ser Ser Tyr Ser Trp Phe Ile Leu Lys
            260                 265                 270         
Thr Lys Ser Ile Phe Pro Gln Asn Thr Leu His Ser Met Tyr Glu Ser
        275                 280                 285             
Leu Glu Gly Gly Tyr Cys Pro Asn Leu Glu Trp Leu Glu Pro Arg Ser
    290                 295                 300                 
Asp Tyr Lys Phe Met Tyr Met Gly Val Met Pro Leu Ser Ala Lys Tyr
305                 310                 315                 320 
Ala Arg Ser Ala Pro Ser Asn Asp Lys Lys Ala Arg Glu Leu Gly Glu
                325                 330                 335     
Lys Tyr Gly Leu Ser Ser Val Val Gly Glu Leu Arg Lys Arg Thr Lys
            340                 345                 350         
Thr Tyr Val Lys His Asp Phe Ala Ser Val Arg Tyr Ile Arg Asp Ala
        355                 360                 365             
Met Ala Cys Thr Ser Gly Ile Phe Leu Val Arg Thr Pro Thr Glu Thr
    370                 375                 380                 
Val Leu Gln Glu Tyr Thr Gln Ser Pro Glu Ile Lys Val Pro Ile Pro
385                 390                 395                 400 
Gln Lys Asp Trp Thr Gly Pro Ile Gly Glu Ile Arg Ile Leu Lys Asp
                405                 410                 415     
Thr Thr Ser Ser Ile Ala Arg Tyr Leu Tyr Arg Thr Trp Tyr Leu Ala
            420                 425                 430         
Ala Ala Arg Met Ala Ala Gln Pro Arg Thr Trp Asp Pro Leu Phe Gln
        435                 440                 445             
Ala Ile Met Arg Ser Gln Tyr Val Thr Ala Arg Gly Gly Ser Gly Ala
    450                 455                 460                 
Ala Leu Arg Glu Ser Leu Tyr Ala Ile Asn Val Ser Leu Pro Asp Phe
465                 470                 475                 480 
Lys Gly Leu Pro Val Lys Ala Ala Thr Lys Ile Phe Gln Ala Ala Gln
                485                 490                 495     
Leu Ala Asn Leu Pro Phe Ser His Thr Ser Val Ala Ile Leu Ala Asp
            500                 505                 510         
Thr Ser Met Gly Leu Arg Asn Gln Val Gln Arg Arg Pro Arg Ser Ile
        515                 520                 525             
Met Pro Leu Asn Val Pro Gln Gln Gln Val Ser Ala Pro His Thr Leu
    530                 535                 540                 
Thr Ala Asp Tyr Ile Asn Tyr His Met Asn Leu Ser Pro Thr Ser Gly
545                 550                 555                 560 
Ser Ala Val Ile Glu Lys Val Ile Pro Leu Gly Val Tyr Ala Ser Ser
                565                 570                 575     
Pro Pro Asn Gln Ser Ile Asn Ile Asp Ile Ser Ala Cys Asp Ala Ser
            580                 585                 590         
Ile Thr Trp Asp Phe Phe Leu Ser Val Ile Met Ala Ala Ile His Glu
        595                 600                 605             
Gly Val Ala Ser Ser Ser Ile Gly Lys Pro Phe Met Gly Val Pro Ala
    610                 615                 620                 
Ser Ile Val Asn Asp Glu Ser Val Val Gly Val Arg Ala Ala Arg Pro
625                 630                 635                 640 
Ile Ser Gly Met Gln Asn Met Ile Gln His Leu Ser Lys Leu Tyr Lys
                645                 650                 655     
Arg Gly Phe Ser Tyr Arg Val Asn Asp Ser Phe Ser Pro Gly Asn Asp
            660                 665                 670         
Phe Thr His Met Thr Thr Thr Phe Pro Ser Gly Ser Thr Ala Thr Ser
        675                 680                 685             
Thr Glu His Thr Ala Asn Asn Ser Thr Met Met Glu Thr Phe Leu Thr
    690                 695                 700                 
Val Trp Gly Pro Glu His Thr Asp Asp Pro Asp Val Leu Arg Leu Met
705                 710                 715                 720 
Lys Ser Leu Thr Ile Gln Arg Asn Tyr Val Cys Gln Gly Asp Asp Gly
                725                 730                 735     
Leu Met Ile Ile Asp Gly Thr Thr Ala Gly Lys Val Asn Ser Glu Thr
            740                 745                 750         
Ile Gln Asn Asp Leu Glu Leu Ile Ser Lys Tyr Gly Glu Glu Phe Gly
        755                 760                 765             
Trp Lys Tyr Asp Ile Ala Tyr Asp Gly Thr Ala Glu Tyr Leu Lys Leu
    770                 775                 780                 
Tyr Phe Ile Phe Gly Cys Arg Ile Pro Asn Leu Ser Arg His Pro Ile
785                 790                 795                 800 
Val Gly Lys Glu Arg Ala Asn Ser Ser Ala Glu Glu Pro Trp Pro Ala
                805                 810                 815     
Ile Leu Asp Gln Ile Met Gly Val Phe Phe Asn Gly Val His Asp Gly
            820                 825                 830         
Leu Gln Trp Gln Arg Trp Ile Arg Tyr Ser Trp Ala Leu Cys Cys Ala
        835                 840                 845             
Phe Ser Arg Gln Arg Thr Met Ile Gly Glu Ser Val Gly Tyr Leu Gln
    850                 855                 860                 
Tyr Pro Met Trp Ser Phe Val Tyr Trp Gly Leu Pro Leu Val Lys Ala
865                 870                 875                 880 
Phe Gly Ser Asp Pro Trp Ile Phe Ser Trp Tyr Met Pro Thr Gly Asp
                885                 890                 895     
Leu Gly Met Tyr Ser Trp Ile Ser Leu Ile Arg Pro Leu Met Thr Arg
            900                 905                 910         
Trp Met Val Ala Asn Gly Tyr Val Thr Asp Arg Cys Ser Thr Val Phe
        915                 920                 925             
Gly Asn Ala Asp Tyr Arg Arg Cys Phe Asn Glu Leu Lys Leu Tyr Gln
    930                 935                 940                 
Gly Tyr Tyr Met Ala Gln Leu Pro Arg Asn Pro Lys Lys Ser Gly Arg
945                 950                 955                 960 
Ala Ala Ser Arg Glu Val Arg Glu Gln Phe Thr Gln Ala Leu Ser Asp
                965                 970                 975     
Tyr Leu Met Gln Asn Pro Glu Leu Lys Ser Arg Val Leu Arg Gly Arg
            980                 985                 990         
Ser Glu Trp Glu Lys Tyr Gly Ala Gly Ile Ile His Asn Pro Pro Ser
        995                 1000                1005            
Leu Phe Asp Val Pro His Lys Trp Tyr Gln Gly Ala Gln Glu Ala Ala
    1010                1015                1020                
Ile Ala Thr Arg Glu Glu Leu Ala Glu Met Asp Glu Thr Leu Met Arg
1025                1030                1035               1040 
Ala Arg Arg His Ser Tyr Ser Ser Phe Ser Lys Leu Leu Glu Ala Tyr
                1045                1050                1055    
Leu Leu Val Lys Trp Arg Met Cys Glu Ala Arg Glu Pro Ser Val Asp
            1060                1065                1070        
Leu Arg Leu Pro Leu Cys Ala Gly Ile Asp Pro Leu Asn Ser Asp Pro
        1075                1080                1085            
Phe Leu Lys Met Val Ser Val Gly Pro Met Leu Gln Ser Thr Arg Lys
    1090                1095                1100                
Tyr Phe Ala Gln Thr Leu Phe Met Ala Lys Thr Val Ser Gly Leu Asp
1105                1110                1115               1120 
Val Asn Ala Ile Asp Ser Ala Leu Leu Arg Leu Arg Thr Leu Gly Ala
                1125                1130                1135    
Asp Lys Lys Ala Leu Thr Ala Gln Leu Leu Met Val Gly Leu Gln Glu
            1140                1145                1150        
Ser Glu Ala Asp Ala Leu Ala Gly Lys Ile Met Leu Gln Asp Val Asn
        1155                1160                1165            
Thr Val Gln Leu Ala Arg Val Val Asn Leu Ala Val Pro Asp Thr Trp
    1170                1175                1180                
Met Ser Leu Asp Phe Asp Ser Met Phe Lys His His Val Lys Leu Leu
1185                1190                1195               1200 
Pro Lys Asp Gly Arg His Leu Asn Thr Asp Ile Pro Pro Arg Met Gly
                1205                1210                1215    
Trp Leu Arg Ala Ile Leu Arg Phe Leu Gly Ala Gly Met Val Met Thr
            1220                1225                1230        
Ala Thr Gly Val Ala Val Asp Ile Tyr Leu Glu Asp Ile His Gly Gly
        1235                1240                1245            
Gly Arg Ser Leu Gly Gln Arg Phe Met Thr Trp Met Arg Gln Glu Gly
    1250                1255                1260                
Arg Ser Ala
1265        


<210> 24
<211> 1196
<212> DNA
<213> Reovirus

<400> 24
gctatttttg cctcttccca gacgttgtcg caatggaggt gtgcttgccc aacggtcatc 60
aggtcgtgga cttgattaac aacgcttttg aaggtcgtgt atcaatctac agcgcgcaag 120
agggatggga caaaacaatc tcagcacagc cagatatgat ggtatgtggt ggcgccgtcg 180
tttgcatgca ttgtctaggt gttgttggat ctctacaacg caagctgaag catttgcctc 240
accatagatg taatcaacag atccgtcatc aggattacgt cgatgtacag ttcgcagacc 300
gtgttactgc tcactggaag cggggtatgc tgtccttcgt tgcgcagatg cacgagatga 360
tgaatgacgt gtcgccagat gacctggatc gtgtgcgtac tgagggaggt tcactagtgg 420
agctgaaccg gcttcaggtt gacccaaatt caatgtttag atcaatacac tcaagttgga 480
cagatccttt gcaggtggtg gacgaccttg acactaagct ggatcagtac tggacagcct 540
taaacctgat gatcgactca tccgacttga tacccaactt tatgatgaga gacccatcac 600
acgcgttcaa tggtgtgaaa ctggagggag atgctcgtca aacccaattc tccaggactt 660
ttgattcgag atcgagtttg gaatggggtg tgatggttta tgattactct gagctggagc 720
atgatccatc gaagggccgt gcttacagaa aggaattggt gacgccagct cgagatttcg 780
gtcactttgg attatcccat tattctaggg cgactacccc aatccttgga aagatgccgg 840
ccgtattctc aggaatgttg actgggaact gtaaaatgta tccattcatt aaaggaacgg 900
ctaagctgaa gacagtgcgc aagctagtgg aggcagtcaa tcatgcttgg ggtgtcgaga 960
agattagata tgctcttggg ccaggtggca tgacgggatg gtacaatagg actatgcaac 1020
aggcccccat tgtgctaact cctgctgctc tcacaatgtt cccagatacc atcaagtttg 1080
gggatttgaa ttatccagtg atgattggcg atccgatgat tcttggctaa acacccccat 1140
cttcacagcg ccgggcttga ccaacctggt gtgacgtggg acaggcttca ttcatc     1196

<210> 25
<211> 365
<212> PRT
<213> Reovirus

<400> 25
Met Glu Val Cys Leu Pro Asn Gly His Gln Val Val Asp Leu Ile Asn
 1               5                  10                  15      
Asn Ala Phe Glu Gly Arg Val Ser Ile Tyr Ser Ala Gln Glu Gly Trp
            20                  25                  30          
Asp Lys Thr Ile Ser Ala Gln Pro Asp Met Met Val Cys Gly Gly Ala
        35                  40                  45              
Val Val Cys Met His Cys Leu Gly Val Val Gly Ser Leu Gln Arg Lys
    50                  55                  60                  
Leu Lys His Leu Pro His His Arg Cys Asn Gln Gln Ile Arg His Gln
65                  70                  75                  80  
Asp Tyr Val Asp Val Gln Phe Ala Asp Arg Val Thr Ala His Trp Lys
                85                  90                  95      
Arg Gly Met Leu Ser Phe Val Ala Gln Met His Glu Met Met Asn Asp
            100                 105                 110         
Val Ser Pro Asp Asp Leu Asp Arg Val Arg Thr Glu Gly Gly Ser Leu
        115                 120                 125             
Val Glu Leu Asn Arg Leu Gln Val Asp Pro Asn Ser Met Phe Arg Ser
    130                 135                 140                 
Ile His Ser Ser Trp Thr Asp Pro Leu Gln Val Val Asp Asp Leu Asp
145                 150                 155                 160 
Thr Lys Leu Asp Gln Tyr Trp Thr Ala Leu Asn Leu Met Ile Asp Ser
                165                 170                 175     
Ser Asp Leu Ile Pro Asn Phe Met Met Arg Asp Pro Ser His Ala Phe
            180                 185                 190         
Asn Gly Val Lys Leu Glu Gly Asp Ala Arg Gln Thr Gln Phe Ser Arg
        195                 200                 205             
Thr Phe Asp Ser Arg Ser Ser Leu Glu Trp Gly Val Met Val Tyr Asp
    210                 215                 220                 
Tyr Ser Glu Leu Glu His Asp Pro Ser Lys Gly Arg Ala Tyr Arg Lys
225                 230                 235                 240 
Glu Leu Val Thr Pro Ala Arg Asp Phe Gly His Phe Gly Leu Ser His
                245                 250                 255     
Tyr Ser Arg Ala Thr Thr Pro Ile Leu Gly Lys Met Pro Ala Val Phe
            260                 265                 270         
Ser Gly Met Leu Thr Gly Asn Cys Lys Met Tyr Pro Phe Ile Lys Gly
        275                 280                 285             
Thr Ala Lys Leu Lys Thr Val Arg Lys Leu Val Glu Ala Val Asn His
    290                 295                 300                 
Ala Trp Gly Val Glu Lys Ile Arg Tyr Ala Leu Gly Pro Gly Gly Met
305                 310                 315                 320 
Thr Gly Trp Tyr Asn Arg Thr Met Gln Gln Ala Pro Ile Val Leu Thr
                325                 330                 335     
Pro Ala Ala Leu Thr Met Phe Pro Asp Thr Ile Lys Phe Gly Asp Leu
            340                 345                 350         
Asn Tyr Pro Val Met Ile Gly Asp Pro Met Ile Leu Gly
        355                 360                 365 


<210> 26
<211> 2203
<212> DNA
<213> Reovirus

<400> 26
gctaatctgc tgaccgttac tctgcaaaga tggggaacgc ttcctctatc gttcagacga 60
tcaacgtcac tggagatggc aatgtattta aaccatcagc tgaaacttca tctaccgctg 120
taccatcgtt aagcttatca cctggaatgc tgaatcccgg aggggtacca tggattgctg 180
ttggagatga gacatctgtg acttcaccag gcgcattacg tcgaatgacg tcaaaggaca 240
tcccggaaac ggcaataatc aacacagaca attcatcagg cgccgtgcca agcgaatcag 300
cgcttgtgcc ctacatcgat gagccgctgg tagtggttac agagcatgct attaccaact 360
tcaccaaagc tgagatggca cttgaattca atcgtgagtt ccttgacaag atgcgtgtgc 420
tgtcagtgtc accaaaatat tcggatcttc tgacctatgt tgactgctac gtcggtgtgt 480
ctgctcgtca ggctttaaac aattttcaga aacaagtgcc tgtgattaca cctactaggc 540
agacgatgta tgtcgactcg atacaagcgg ccttgaaagc tttagaaaag tgggagattg 600
atctgagagt ggctcaaacg ttgctgccta cgaacgttcc gattggagaa gtctcttgtc 660
caatgcagtc ggtagtgaaa ctgctggatg atcagctgcc agatgacacg ctgatacgga 720
ggtatcccaa ggaagccgcc gtcgctttgg ctaaacgaaa cgggggaata caatggatgg 780
acgtatcaga aggcaccgtg atgaacgagg ctgtcaacgc tgttgcagct agtgcactgg 840
caccttcagc atcagcccca cccttagaag agaagtcaaa gttaaccgaa caagcgatgg 900
atctcgtgac cgcggctgag cctgagataa ttgcctcact cgcgccagtt cccgcacccg 960
tgtttgccat accacctaaa ccagcagatt ataatgtgcg tactctgagg atcgacgagg 1020
ccacttggct gcgaatgatt ccaaaatcaa tgaacacacc ttttcaaatc caggtgactg 1080
ataacacagg aactaattgg catctcaatt tgaggggggg gactcgtgta gtgaatctgg 1140
accaaatcgc tccgatgcgg tttgtattag atttaggggg aaagagttat aaagagacga 1200
gctgggatcc aaacggcaag aaggtcggat tcatcgtttt tcaatcgaag ataccattcg 1260
aactttggac tgctgcttca cagatcggtc aagccacggt ggttaactat gtccaactat 1320
acgctgaaga cagctcattt accgcgcagt ctatcattgc tactacctct ttggcttata 1380
actatgagcc tgagcagttg aataagactg accctgagat gaattattat cttttggcga 1440
cctttataga ctcagccgct ataacgccaa cgaatatgac acagcctgat gtttgggatg 1500
ccttgctgac gatgtcccca ctatcagctg gcgaggtgac agtgaagggt gcggtagtga 1560
gtgaagtagt ccctgcagac ttgataggta gctacactcc agaatcccta aacgcctcac 1620
ttccgaatga tgctgctaga tgcatgatcg atagagcttc gaagatagcc gaagcaatca 1680
agattgatga tgatgctgga ccagatgaat attccccaaa ctctgtacca attcaaggtc 1740
agcttgctat ctcgcaactc gaaactggat atggtgtgcg aatattcaac cctaaaggga 1800
tcctttctaa aattgcatct agggcaatgc aggctttcat tggtgacccg agcacaatca 1860
tcacgcaggc ggcgccagtg ttatcagaca agaataattg gattgcattg gcacagggag 1920
tgaaaactag tctgcgtact aaaagtctat cagcgggagt gaagactgca gtgagtaagc 1980
tgagctcatc tgagtctatc cagaattgga ctcaaggatt cttggataaa gtgtcagcgc 2040
attttccagc accaaagccc gattgtccga ctagcggaga tagtggtgaa tcgtctaatc 2100
gccgagtgaa gcgcgactca tacgcaggag tggtcaaacg tgggtacaca cgttaggccg 2160
ctcgccctgg tgacgcgggg ttaagggatg caggcaaatc atc                   2203

<210> 27
<211> 708
<212> PRT
<213> Reovirus

<400> 27
Met Gly Asn Ala Ser Ser Ile Val Gln Thr Ile Asn Val Thr Gly Asp
 1               5                  10                  15      
Gly Asn Val Phe Lys Pro Ser Ala Glu Thr Ser Ser Thr Ala Val Pro
            20                  25                  30          
Ser Leu Ser Leu Ser Pro Gly Met Leu Asn Pro Gly Gly Val Pro Trp
        35                  40                  45              
Ile Ala Val Gly Asp Glu Thr Ser Val Thr Ser Pro Gly Ala Leu Arg
    50                  55                  60                  
Arg Met Thr Ser Lys Asp Ile Pro Glu Thr Ala Ile Ile Asn Thr Asp
65                  70                  75                  80  
Asn Ser Ser Gly Ala Val Pro Ser Glu Ser Ala Leu Val Pro Tyr Ile
                85                  90                  95      
Asp Glu Pro Leu Val Val Val Thr Glu His Ala Ile Thr Asn Phe Thr
            100                 105                 110         
Lys Ala Glu Met Ala Leu Glu Phe Asn Arg Glu Phe Leu Asp Lys Met
        115                 120                 125             
Arg Val Leu Ser Val Ser Pro Lys Tyr Ser Asp Leu Leu Thr Tyr Val
    130                 135                 140                 
Asp Cys Tyr Val Gly Val Ser Ala Arg Gln Ala Leu Asn Asn Phe Gln
145                 150                 155                 160 
Lys Gln Val Pro Val Ile Thr Pro Thr Arg Gln Thr Met Tyr Val Asp
                165                 170                 175     
Ser Ile Gln Ala Ala Leu Lys Ala Leu Glu Lys Trp Glu Ile Asp Leu
            180                 185                 190         
Arg Val Ala Gln Thr Leu Leu Pro Thr Asn Val Pro Ile Gly Glu Val
        195                 200                 205             
Ser Cys Pro Met Gln Ser Val Val Lys Leu Leu Asp Asp Gln Leu Pro
    210                 215                 220                 
Asp Asp Thr Leu Ile Arg Arg Tyr Pro Lys Glu Ala Ala Val Ala Leu
225                 230                 235                 240 
Ala Lys Arg Asn Gly Gly Ile Gln Trp Met Asp Val Ser Glu Gly Thr
                245                 250                 255     
Val Met Asn Glu Ala Val Asn Ala Val Ala Ala Ser Ala Leu Ala Pro
            260                 265                 270         
Ser Ala Ser Ala Pro Pro Leu Glu Glu Lys Ser Lys Leu Thr Glu Gln
        275                 280                 285             
Ala Met Asp Leu Val Thr Ala Ala Glu Pro Glu Ile Ile Ala Ser Leu
    290                 295                 300                 
Ala Pro Val Pro Ala Pro Val Phe Ala Ile Pro Pro Lys Pro Ala Asp
305                 310                 315                 320 
Tyr Asn Val Arg Thr Leu Arg Ile Asp Glu Ala Thr Trp Leu Arg Met
                325                 330                 335     
Ile Pro Lys Ser Met Asn Thr Pro Phe Gln Ile Gln Val Thr Asp Asn
            340                 345                 350         
Thr Gly Thr Asn Trp His Leu Asn Leu Arg Gly Gly Thr Arg Val Val
        355                 360                 365             
Asn Leu Asp Gln Ile Ala Pro Met Arg Phe Val Leu Asp Leu Gly Gly
    370                 375                 380                 
Lys Ser Tyr Lys Glu Thr Ser Trp Asp Pro Asn Gly Lys Lys Val Gly
385                 390                 395                 400 
Phe Ile Val Phe Gln Ser Lys Ile Pro Phe Glu Leu Trp Thr Ala Ala
                405                 410                 415     
Ser Gln Ile Gly Gln Ala Thr Val Val Asn Tyr Val Gln Leu Tyr Ala
            420                 425                 430         
Glu Asp Ser Ser Phe Thr Ala Gln Ser Ile Ile Ala Thr Thr Ser Leu
        435                 440                 445             
Ala Tyr Asn Tyr Glu Pro Glu Gln Leu Asn Lys Thr Asp Pro Glu Met
    450                 455                 460                 
Asn Tyr Tyr Leu Leu Ala Thr Phe Ile Asp Ser Ala Ala Ile Thr Pro
465                 470                 475                 480 
Thr Asn Met Thr Gln Pro Asp Val Trp Asp Ala Leu Leu Thr Met Ser
                485                 490                 495     
Pro Leu Ser Ala Gly Glu Val Thr Val Lys Gly Ala Val Val Ser Glu
            500                 505                 510         
Val Val Pro Ala Asp Leu Ile Gly Ser Tyr Thr Pro Glu Ser Leu Asn
        515                 520                 525             
Ala Ser Leu Pro Asn Asp Ala Ala Arg Cys Met Ile Asp Arg Ala Ser
    530                 535                 540                 
Lys Ile Ala Glu Ala Ile Lys Ile Asp Asp Asp Ala Gly Pro Asp Glu
545                 550                 555                 560 
Tyr Ser Pro Asn Ser Val Pro Ile Gln Gly Gln Leu Ala Ile Ser Gln
                565                 570                 575     
Leu Glu Thr Gly Tyr Gly Val Arg Ile Phe Asn Pro Lys Gly Ile Leu
            580                 585                 590         
Ser Lys Ile Ala Ser Arg Ala Met Gln Ala Phe Ile Gly Asp Pro Ser
        595                 600                 605             
Thr Ile Ile Thr Gln Ala Ala Pro Val Leu Ser Asp Lys Asn Asn Trp
    610                 615                 620                 
Ile Ala Leu Ala Gln Gly Val Lys Thr Ser Leu Arg Thr Lys Ser Leu
625                 630                 635                 640 
Ser Ala Gly Val Lys Thr Ala Val Ser Lys Leu Ser Ser Ser Glu Ser
                645                 650                 655     
Ile Gln Asn Trp Thr Gln Gly Phe Leu Asp Lys Val Ser Ala His Phe
            660                 665                 670         
Pro Ala Pro Lys Pro Asp Cys Pro Thr Ser Gly Asp Ser Gly Glu Ser
        675                 680                 685             
Ser Asn Arg Arg Val Lys Arg Asp Ser Tyr Ala Gly Val Val Lys Arg
    690                 695                 700                 
Gly Tyr Thr Arg
705             


<210> 28
<211> 2304
<212> DNA
<213> Reovirus

<400> 28
gctattcgcg gtcatggctt acatcgcagt tcctgcggtg gtggattcac gttcgagtga 60
ggctattgga ctgctagaat cgtttggagt agacgctggg gctgacgcga atgacgtttc 120
atatcaagat catgactatg tgttggatca gttacagtac atgttagatg gatatgaggc 180
tggtgacgtt atcgatgcac tcgtccacaa gaattggtta catcactctg tctattgctt 240
gttgccaccc aaaagtcaac tattagagta ttggaaaagt aatccttcag cgataccgga 300
caacgttgat cgtcggcttc gtaaacgact aatgctaaag aaagatctca ggaaagatga 360
tgaatacaat cagctagcgc gtgctttcaa gatatcggat gtctacgcac ctctcatctc 420
atccacgacg tcaccgatga caatgataca gaacttgaat cgaggcgaga tcgtgtacac 480
cacgacggac agggtaatag gggctagaat cttgttatat gctcctagaa agtactatgc 540
gtcaactctg tcatttacta tgactaagtg catcattccg tttggtaaag aggtgggtcg 600
tgttcctcac tctcgattta atgttggcac atttccgtca attgctaccc cgaaatgttt 660
tgtcatgagt ggggttgata ttgagtccat cccaaatgaa tttatcaagt tgttttacca 720
gcgcgtcaag agtgttcacg ctaacatact aaatgacata tctcctcaga tcgtctctga 780
catgataaac agaaagcgtc tgcgcgttca tactccatca gatcgtcgag ccgcgcagtt 840
gatgcatttg ccttaccatg ttaaacgagg agcgtctcac gtcgacgttt acaaggtgga 900
tgttgtagac atgttgttcg aggtagtgga tgtggccgat gggttgcgca acgtatctag 960
gaaactaact atgcataccg ttcctgtatg tattcttgaa atgttgggta ttgagattgc 1020
ggactattgc attcgtcaag aggatggaat gctcacagat tggttcctac ttttaaccat 1080
gctatctgat ggcttgactg atagaaggac gcattgtcaa tacttgatga atccgtcaag 1140
tgtgcctcct gatgtgatac ttaacatctc aattactgga tttataaata gacatacaat 1200
cgatgtcatg cctgacatat atgacttcgt taaacccatt ggcgctgtgc tgcctaaggg 1260
atcatttaaa tcaacaatta tgagagttct tgattcaata tcaatattag gaatccaaat 1320
catgccgcgc gcgcatgtag ttgactcaga tgaggtgggc gagcaaatgg agcctacgtt 1380
tgagcaggcg gttatggaga tatacaaagg gattgctggc gttgactcgc tggatgatct 1440
catcaagtgg gtgttgaact cggatctcat tccgcatgat gacaggcttg gtcaattatt 1500
tcaagcgttt ttgcctctcg caaaggactt attagctcca atggccagaa agttttatga 1560
taactcaatg agtgagggta gattgctaac attcgctcat gccgacagtg agttgctgaa 1620
cgcaaattat tttggtcatt tattgcgact aaaaatacca tatattacag aggttaatct 1680
gatgattcgc aagaatcgtg agggtggaga gctatttcag cttgtgttat cttatctata 1740
taaaatgtat gctactagcg cgcagcctaa atggtttgga tcattattgc gattgttaat 1800
atgtccctgg ttacatatgg agaaattaat aggagaagca gacccggcat ctacgtcggc 1860
tgaaattggg tggcatatcc ctcgtgaaca gctgatgcaa gatggatggt gtggatgtga 1920
agacggattc attccctatg ttagcatacg tgcgccaaga ctggttatag aggagttgat 1980
ggagaagaac tggggccaat atcatgccca agttattgtc actgatcagc ttgtcgtagg 2040
cgaaccgcgg agggtatctg ctaaggctgt gatcaagggt aaccacttac cagttaagtt 2100
agtttcacga tttgcatgtt tcacattgac ggcgaagtat gagatgaggc tttcgtgcgg 2160
ccatagcact ggacgtggag ctgcatacag tgcgagacta gctttccgat ctgacttggc 2220
gtgatccgtg acatgcgtag tgtgacacct gctcctaggt caatgggggt agggggcggg 2280
ctaagactac gtacgcgctt catc                                        2304

<210> 29
<211> 736
<212> PRT
<213> Reovirus

<400> 29
Met Ala Tyr Ile Ala Val Pro Ala Val Val Asp Ser Arg Ser Ser Glu
 1               5                  10                  15      
Ala Ile Gly Leu Leu Glu Ser Phe Gly Val Asp Ala Gly Ala Asp Ala
            20                  25                  30          
Asn Asp Val Ser Tyr Gln Asp His Asp Tyr Val Leu Asp Gln Leu Gln
        35                  40                  45              
Tyr Met Leu Asp Gly Tyr Glu Ala Gly Asp Val Ile Asp Ala Leu Val
    50                  55                  60                  
His Lys Asn Trp Leu His His Ser Val Tyr Cys Leu Leu Pro Pro Lys
65                  70                  75                  80  
Ser Gln Leu Leu Glu Tyr Trp Lys Ser Asn Pro Ser Ala Ile Pro Asp
                85                  90                  95      
Asn Val Asp Arg Arg Leu Arg Lys Arg Leu Met Leu Lys Lys Asp Leu
            100                 105                 110         
Arg Lys Asp Asp Glu Tyr Asn Gln Leu Ala Arg Ala Phe Lys Ile Ser
        115                 120                 125             
Asp Val Tyr Ala Pro Leu Ile Ser Ser Thr Thr Ser Pro Met Thr Met
    130                 135                 140                 
Ile Gln Asn Leu Asn Arg Gly Glu Ile Val Tyr Thr Thr Thr Asp Arg
145                 150                 155                 160 
Val Ile Gly Ala Arg Ile Leu Leu Tyr Ala Pro Arg Lys Tyr Tyr Ala
                165                 170                 175     
Ser Thr Leu Ser Phe Thr Met Thr Lys Cys Ile Ile Pro Phe Gly Lys
            180                 185                 190         
Glu Val Gly Arg Val Pro His Ser Arg Phe Asn Val Gly Thr Phe Pro
        195                 200                 205             
Ser Ile Ala Thr Pro Lys Cys Phe Val Met Ser Gly Val Asp Ile Glu
    210                 215                 220                 
Ser Ile Pro Asn Glu Phe Ile Lys Leu Phe Tyr Gln Arg Val Lys Ser
225                 230                 235                 240 
Val His Ala Asn Ile Leu Asn Asp Ile Ser Pro Gln Ile Val Ser Asp
                245                 250                 255     
Met Ile Asn Arg Lys Arg Leu Arg Val His Thr Pro Ser Asp Arg Arg
            260                 265                 270         
Ala Ala Gln Leu Met His Leu Pro Tyr His Val Lys Arg Gly Ala Ser
        275                 280                 285             
His Val Asp Val Tyr Lys Val Asp Val Val Asp Met Leu Phe Glu Val
    290                 295                 300                 
Val Asp Val Ala Asp Gly Leu Arg Asn Val Ser Arg Lys Leu Thr Met
305                 310                 315                 320 
His Thr Val Pro Val Cys Ile Leu Glu Met Leu Gly Ile Glu Ile Ala
                325                 330                 335     
Asp Tyr Cys Ile Arg Gln Glu Asp Gly Met Leu Thr Asp Trp Phe Leu
            340                 345                 350         
Leu Leu Thr Met Leu Ser Asp Gly Leu Thr Asp Arg Arg Thr His Cys
        355                 360                 365             
Gln Tyr Leu Met Asn Pro Ser Ser Val Pro Pro Asp Val Ile Leu Asn
    370                 375                 380                 
Ile Ser Ile Thr Gly Phe Ile Asn Arg His Thr Ile Asp Val Met Pro
385                 390                 395                 400 
Asp Ile Tyr Asp Phe Val Lys Pro Ile Gly Ala Val Leu Pro Lys Gly
                405                 410                 415     
Ser Phe Lys Ser Thr Ile Met Arg Val Leu Asp Ser Ile Ser Ile Leu
            420                 425                 430         
Gly Ile Gln Ile Met Pro Arg Ala His Val Val Asp Ser Asp Glu Val
        435                 440                 445             
Gly Glu Gln Met Glu Pro Thr Phe Glu Gln Ala Val Met Glu Ile Tyr
    450                 455                 460                 
Lys Gly Ile Ala Gly Val Asp Ser Leu Asp Asp Leu Ile Lys Trp Val
465                 470                 475                 480 
Leu Asn Ser Asp Leu Ile Pro His Asp Asp Arg Leu Gly Gln Leu Phe
                485                 490                 495     
Gln Ala Phe Leu Pro Leu Ala Lys Asp Leu Leu Ala Pro Met Ala Arg
            500                 505                 510         
Lys Phe Tyr Asp Asn Ser Met Ser Glu Gly Arg Leu Leu Thr Phe Ala
        515                 520                 525             
His Ala Asp Ser Glu Leu Leu Asn Ala Asn Tyr Phe Gly His Leu Leu
    530                 535                 540                 
Arg Leu Lys Ile Pro Tyr Ile Thr Glu Val Asn Leu Met Ile Arg Lys
545                 550                 555                 560 
Asn Arg Glu Gly Gly Glu Leu Phe Gln Leu Val Leu Ser Tyr Leu Tyr
                565                 570                 575     
Lys Met Tyr Ala Thr Ser Ala Gln Pro Lys Trp Phe Gly Ser Leu Leu
            580                 585                 590         
Arg Leu Leu Ile Cys Pro Trp Leu His Met Glu Lys Leu Ile Gly Glu
        595                 600                 605             
Ala Asp Pro Ala Ser Thr Ser Ala Glu Ile Gly Trp His Ile Pro Arg
    610                 615                 620                 
Glu Gln Leu Met Gln Asp Gly Trp Cys Gly Cys Glu Asp Gly Phe Ile
625                 630                 635                 640 
Pro Tyr Val Ser Ile Arg Ala Pro Arg Leu Val Ile Glu Glu Leu Met
                645                 650                 655     
Glu Lys Asn Trp Gly Gln Tyr His Ala Gln Val Ile Val Thr Asp Gln
            660                 665                 670         
Leu Val Val Gly Glu Pro Arg Arg Val Ser Ala Lys Ala Val Ile Lys
        675                 680                 685             
Gly Asn His Leu Pro Val Lys Leu Val Ser Arg Phe Ala Cys Phe Thr
    690                 695                 700                 
Leu Thr Ala Lys Tyr Glu Met Arg Leu Ser Cys Gly His Ser Thr Gly
705                 710                 715                 720 
Arg Gly Ala Ala Tyr Ser Ala Arg Leu Ala Phe Arg Ser Asp Leu Ala
                725                 730                 735     


<210> 30
<211> 418
<212> PRT
<213> Reovirus

<400> 30
Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly Leu
 1               5                  10                  15      
Gln Asn Val Pro Ile Asn Asp Glu Leu Ser Ser His Leu Leu Arg Ala
            20                  25                  30          
Gly Asn Ser Pro Trp Gln Leu Thr Gln Phe Leu Asp Trp Ile Ser Leu
        35                  40                  45              
Gly Arg Gly Leu Ala Thr Ser Ala Leu Val Pro Thr Ala Gly Ser Arg
    50                  55                  60                  
Tyr Tyr Gln Met Ser Cys Leu Leu Ser Gly Thr Leu Gln Ile Pro Phe
65                  70                  75                  80  
Arg Pro Asn His Arg Trp Gly Asp Ile Arg Phe Leu Arg Leu Val Trp
                85                  90                  95      
Ser Ala Pro Thr Leu Asp Gly Leu Val Val Ala Pro Pro Gln Val Leu
            100                 105                 110         
Ala Gln Pro Ala Leu Gln Ala Gln Ala Asp Arg Val Tyr Asp Cys Asp
        115                 120                 125             
Asp Tyr Pro Phe Leu Ala Arg Asp Pro Arg Phe Lys His Arg Val Tyr
    130                 135                 140                 
Gln Gln Leu Ser Ala Val Thr Leu Leu Asn Leu Thr Gly Phe Gly Pro
145                 150                 155                 160 
Ile Ser Tyr Val Arg Val Asp Glu Asp Met Trp Ser Gly Asp Val Asn
                165                 170                 175     
Gln Leu Leu Met Asn Tyr Phe Gly His Thr Phe Ala Glu Ile Ala Tyr
            180                 185                 190         
Thr Leu Cys Gln Ala Ser Ala Asn Arg Pro Trp Glu Tyr Asp Gly Thr
        195                 200                 205             
Tyr Ala Arg Met Thr Gln Ile Val Leu Ser Leu Phe Trp Leu Ser Tyr
    210                 215                 220                 
Val Gly Val Ile His Gln Gln Asn Thr Tyr Arg Thr Phe Tyr Phe Gln
225                 230                 235                 240 
Cys Asn Arg Arg Gly Asp Ala Ala Glu Val Trp Ile Leu Ser Cys Ser
                245                 250                 255     
Leu Asn His Ser Ala Gln Ile Arg Pro Gly Asn Arg Ser Leu Phe Val
            260                 265                 270         
Met Pro Thr Ser Pro Asp Trp Asn Met Asp Val Asn Leu Ile Leu Ser
        275                 280                 285             
Ser Thr Leu Thr Gly Cys Leu Cys Ser Gly Ser Gln Leu Pro Leu Ile
    290                 295                 300                 
Asp Asn Asn Ser Val Pro Ala Val Ser Arg Asn Ile His Gly Trp Thr
305                 310                 315                 320 
Gly Arg Ala Gly Asn Gln Leu His Gly Phe Gln Val Arg Arg Met Val
                325                 330                 335     
Thr Glu Phe Cys Asp Arg Leu Arg Arg Asp Gly Val Met Thr Gln Ala
            340                 345                 350         
Gln Gln Asn Gln Val Glu Ala Leu Ala Asp Gln Thr Gln Gln Phe Lys
        355                 360                 365             
Arg Asp Lys Leu Glu Thr Trp Ala Arg Glu Asp Asp Gln Tyr Asn Gln
    370                 375                 380                 
Ala His Pro Asn Ser Thr Met Phe Arg Thr Lys Pro Phe Thr Asn Ala
385                 390                 395                 400 
Gln Trp Gly Arg Gly Asn Thr Gly Ala Thr Ser Ala Ala Ile Ala Ala
                405                 410                 415     
Leu Ile

