﻿               SEQUENCE LISTING

<110> Universität zu Köln

<120> Novel NRG1 fusion genes in cancer

<130> W2361 PCT S3

<150> EP 13 17 9596.5
<151> 2013-08-07

<150> EP 13 19 8520.2
<151> 2013-12-19

<160> 37

<170> BiSSAP 1.2

<210> 1
<211> 282
<212> PRT
<213> Homo sapiens

<220> 
<223> CD74-NRG1 fusion protein

<400> 1
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             
Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala 
    210                 215                 220                 
Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
225                 230                 235                 240 
Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
                245                 250                 255     
Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser 
            260                 265                 270         
Thr Ser Thr Pro Phe Leu Ser Leu Pro Glu 
        275                 280         

<210> 2
<211> 849
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..849
<223> /mol_type="unassigned DNA"
      /note="CD74-NRG1 fusion protein"
      /organism="Homo sapiens"

<400> 2
atgcacagga ggagaagcag gagctgtcgg gaagatcaga agccagtcat ggatgaccag      60

cgcgacctta tctccaacaa tgagcaactg cccatgctgg gccggcgccc tggggccccg     120

gagagcaagt gcagccgcgg agccctgtac acaggctttt ccatcctggt gactctgctc     180

ctcgctggcc aggccaccac cgcctacttc ctgtaccagc agcagggccg gctggacaaa     240

ctgacagtca cctcccagaa cctgcagctg gagaacctgc gcatgaagct tcccaagcct     300

cccaagcctg tgagcaagat gcgcatggcc accccgctgc tgatgcaggc gctgcccatg     360

ggagccctgc cccaggggcc catgcagaat gccaccaagt atggcaacat gacagaggac     420

catgtgatgc acctgctcca gaatgctgac cccctgaagg tgtacccgcc actgaagggg     480

agcttcccgg agaacctgag acaccttaag aacaccatgg agaccataga ctggaaggtc     540

tttgagagct ggatgcacca ttggctcctg tttgaaatga gcaggcactc cttggagcaa     600

aagcccactg acgctccacc gaaagctaca tctacatcca ccactgggac aagccatctt     660

gtaaaatgtg cggagaagga gaaaactttc tgtgtgaatg gaggggagtg cttcatggtg     720

aaagaccttt caaacccctc gagatacttg tgcaagtgcc caaatgagtt tactggtgat     780

cgctgccaaa actacgtaat ggccagcttc tacagtacgt ccactccctt tctgtctctg     840

cctgaatag                                                             849


<210> 3
<211> 849
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..849
<223> /mol_type="mRNA"
      /note="CD74-NRG1 fusion protein"
      /organism="Homo sapiens"

<400> 3
augcacagga ggagaagcag gagcugucgg gaagaucaga agccagucau ggaugaccag      60

cgcgaccuua ucuccaacaa ugagcaacug cccaugcugg gccggcgccc uggggccccg     120

gagagcaagu gcagccgcgg agcccuguac acaggcuuuu ccauccuggu gacucugcuc     180

cucgcuggcc aggccaccac cgccuacuuc cuguaccagc agcagggccg gcuggacaaa     240

cugacaguca ccucccagaa ccugcagcug gagaaccugc gcaugaagcu ucccaagccu     300

cccaagccug ugagcaagau gcgcauggcc accccgcugc ugaugcaggc gcugcccaug     360

ggagcccugc cccaggggcc caugcagaau gccaccaagu auggcaacau gacagaggac     420

caugugaugc accugcucca gaaugcugac ccccugaagg uguacccgcc acugaagggg     480

agcuucccgg agaaccugag acaccuuaag aacaccaugg agaccauaga cuggaagguc     540

uuugagagcu ggaugcacca uuggcuccug uuugaaauga gcaggcacuc cuuggagcaa     600

aagcccacug acgcuccacc gaaagcuaca ucuacaucca ccacugggac aagccaucuu     660

guaaaaugug cggagaagga gaaaacuuuc ugugugaaug gaggggagug cuucauggug     720

aaagaccuuu caaaccccuc gagauacuug ugcaagugcc caaaugaguu uacuggugau     780

cgcugccaaa acuacguaau ggccagcuuc uacaguacgu ccacucccuu ucugucucug     840

ccugaauag                                                             849


<210> 4
<211> 645
<212> PRT
<213> Homo sapiens

<220> 
<223> NRG1

<400> 4
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      
Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          
Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              
Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  
Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  
Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      
Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         
Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             
Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 
Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 
Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     
Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         
Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             
Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 
Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
225                 230                 235                 240 
Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile 
                245                 250                 255     
Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr 
            260                 265                 270         
Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg 
        275                 280                 285             
Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro 
    290                 295                 300                 
Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys 
305                 310                 315                 320 
Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser 
                325                 330                 335     
Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val 
            340                 345                 350         
Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile 
        355                 360                 365             
Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser 
    370                 375                 380                 
Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr 
385                 390                 395                 400 
Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr 
                405                 410                 415     
Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala 
            420                 425                 430         
Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser 
        435                 440                 445             
Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met 
    450                 455                 460                 
Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu 
465                 470                 475                 480 
Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe 
                485                 490                 495     
Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His 
            500                 505                 510         
Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu 
        515                 520                 525             
Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys 
    530                 535                 540                 
Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His 
545                 550                 555                 560 
Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser 
                565                 570                 575     
Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro 
            580                 585                 590         
Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro 
        595                 600                 605             
Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser 
    610                 615                 620                 
Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln 
625                 630                 635                 640 
Asp Pro Ile Ala Val 
                645 

<210> 5
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<223> CD74

<400> 5
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
    210                 215                 220                 
Gln Asp Leu Gly Pro Val Pro Met 
225                 230         

<210> 6
<211> 74
<212> PRT
<213> Homo sapiens

<220> 
<223> NRG1

<400> 6
Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala 
1               5                   10                  15      
Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
            20                  25                  30          
Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
        35                  40                  45              
Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser 
    50                  55                  60                  
Thr Ser Thr Pro Phe Leu Ser Leu Pro Glu 
65                  70                  

<210> 7
<211> 208
<212> PRT
<213> Homo sapiens

<220> 
<223> CD74

<400> 7
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             



<210> 8
<211> 224
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..224
<223> /mol_type="mRNA"
      /note="NRG1"
      /organism="Homo sapiens"

<400> 8
cuacaucuac auccaccacu gggacaagcc aucuuguaaa augugcggag aaggagaaaa     60

cuuucugugu gaauggaggg gagugcuuca uggugaaaga ccuuucaaac cccucgagau    120

acuugugcaa gugcccaaau gaguuuacug gugaucgcug ccaaaacuac guaauggcca    180

gcuucuacag uacguccacu cccuuucugu cucugccuga auag                     224


<210> 9
<211> 625
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..625
<223> /mol_type="mRNA"
      /note="CD74"
      /organism="Homo sapiens"

<400> 9
augcacagga ggagaagcag gagcugucgg gaagaucaga agccagucau ggaugaccag      60

cgcgaccuua ucuccaacaa ugagcaacug cccaugcugg gccggcgccc uggggccccg     120

gagagcaagu gcagccgcgg agcccuguac acaggcuuuu ccauccuggu gacucugcuc     180

cucgcuggcc aggccaccac cgccuacuuc cuguaccagc agcagggccg gcuggacaaa     240

cugacaguca ccucccagaa ccugcagcug gagaaccugc gcaugaagcu ucccaagccu     300

cccaagccug ugagcaagau gcgcauggcc accccgcugc ugaugcaggc gcugcccaug     360

ggagcccugc cccaggggcc caugcagaau gccaccaagu auggcaacau gacagaggac     420

caugugaugc accugcucca gaaugcugac ccccugaagg uguacccgcc acugaagggg     480

agcuucccgg agaaccugag acaccuuaag aacaccaugg agaccauaga cuggaagguc     540

uuugagagcu ggaugcacca uuggcuccug uuugaaauga gcaggcacuc cuuggagcaa     600

aagcccacug acgcuccacc gaaag                                           625


<210> 10
<211> 277
<212> PRT
<213> Homo sapiens

<220> 
<223> MTSS1-NRG1 fusion protein

<400> 10
Met Glu Ala Val Ile Glu Lys Glu Cys Ser Ala Leu Gly Gly Leu Phe 
1               5                   10                  15      
Gln Thr Ile Ile Ser Asp Met Lys Gly Ser Tyr Pro Val Trp Glu Asp 
            20                  25                  30          
Phe Ile Asn Lys Ala Gly Lys Leu Gln Ser Gln Leu Arg Thr Thr Val 
        35                  40                  45              
Val Ala Ala Ala Ala Phe Leu Asp Ala Phe Gln Lys Val Ala Asp Met 
    50                  55                  60                  
Ala Thr Asn Thr Arg Ala Leu Pro Pro Gln Leu Lys Glu Met Lys Ser 
65                  70                  75                  80  
Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser 
                85                  90                  95      
Ser Glu Tyr Ser Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu 
            100                 105                 110         
Leu Asn Arg Lys Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro 
        115                 120                 125             
Gly Lys Ser Glu Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly 
    130                 135                 140                 
Glu Tyr Met Cys Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser 
145                 150                 155                 160 
Ala Asn Ile Thr Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro 
                165                 170                 175     
Ala Ser Thr Glu Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile 
            180                 185                 190         
Ser Val Ser Thr Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser 
        195                 200                 205             
Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr 
    210                 215                 220                 
Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn 
225                 230                 235                 240 
Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg 
                245                 250                 255     
Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe 
            260                 265                 270         
Leu Ser Leu Pro Glu 
        275         

<210> 11
<211> 834
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..834
<223> /mol_type="unassigned DNA"
      /note="MTSS-NRG1 fusion protein"
      /organism="Homo sapiens"

<400> 11
atggaggctg tgattgagaa ggaatgcagc gcgctcggag gcctcttcca gaccatcatc      60

agcgacatga aggggagcta tccagtttgg gaagatttca taaacaaagc aggaaagctg     120

cagtcccagc ttcggacaac agtagtagca gcagctgcct tcttggacgc ctttcagaaa     180

gtggctgaca tggccaccaa cacacgtgcc ttgcctcccc aattgaaaga gatgaaaagc     240

caggaatcgg ctgcaggttc caaactagtc cttcggtgtg aaaccagttc tgaatactcc     300

tctctcagat tcaagtggtt caagaatggg aatgaattga atcgaaaaaa caaaccacaa     360

aatatcaaga tacaaaaaaa gccagggaag tcagaacttc gcattaacaa agcatcactg     420

gctgattctg gagagtatat gtgcaaagtg atcagcaaat taggaaatga cagtgcctct     480

gccaatatca ccatcgtgga atcaaacgag atcatcactg gtatgccagc ctcaactgaa     540

ggagcatatg tgtcttcaga gtctcccatt agaatatcag tatccacaga aggagcaaat     600

acttcttcat ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag     660

aaggagaaaa ctttctgtgt gaatggaggg gagtgcttca tggtgaaaga cctttcaaac     720

ccctcgagat acttgtgcaa gtgcccaaat gagtttactg gtgatcgctg ccaaaactac     780

gtaatggcca gcttctacag tacgtccact ccctttctgt ctctgcctga atag           834


<210> 12
<211> 834
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..834
<223> /mol_type="mRNA"
      /note="MTSS1-NRG1 fusion protein"
      /organism="Homo sapiens"

<400> 12
auggaggcug ugauugagaa ggaaugcagc gcgcucggag gccucuucca gaccaucauc      60

agcgacauga aggggagcua uccaguuugg gaagauuuca uaaacaaagc aggaaagcug     120

cagucccagc uucggacaac aguaguagca gcagcugccu ucuuggacgc cuuucagaaa     180

guggcugaca uggccaccaa cacacgugcc uugccucccc aauugaaaga gaugaaaagc     240

caggaaucgg cugcagguuc caaacuaguc cuucggugug aaaccaguuc ugaauacucc     300

ucucucagau ucaagugguu caagaauggg aaugaauuga aucgaaaaaa caaaccacaa     360

aauaucaaga uacaaaaaaa gccagggaag ucagaacuuc gcauuaacaa agcaucacug     420

gcugauucug gagaguauau gugcaaagug aucagcaaau uaggaaauga cagugccucu     480

gccaauauca ccaucgugga aucaaacgag aucaucacug guaugccagc cucaacugaa     540

ggagcauaug ugucuucaga gucucccauu agaauaucag uauccacaga aggagcaaau     600

acuucuucau cuacaucuac auccaccacu gggacaagcc aucuuguaaa augugcggag     660

aaggagaaaa cuuucugugu gaauggaggg gagugcuuca uggugaaaga ccuuucaaac     720

cccucgagau acuugugcaa gugcccaaau gaguuuacug gugaucgcug ccaaaacuac     780

guaauggcca gcuucuacag uacguccacu cccuuucugu cucugccuga auag           834


<210> 13
<211> 208
<212> PRT
<213> Homo sapiens

<220> 
<223> NRG1

<400> 13
Ala Leu Pro Pro Gln Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala 
1               5                   10                  15      
Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser 
            20                  25                  30          
Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn 
        35                  40                  45              
Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu 
    50                  55                  60                  
Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys 
65                  70                  75                  80  
Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile 
                85                  90                  95      
Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly 
            100                 105                 110         
Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu 
        115                 120                 125             
Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser 
    130                 135                 140                 
His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
145                 150                 155                 160 
Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
                165                 170                 175     
Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val 
            180                 185                 190         
Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro Glu 
        195                 200                 205             



<210> 14
<211> 69
<212> PRT
<213> Homo sapiens

<220> 
<223> MTSS1

<400> 14
Met Glu Ala Val Ile Glu Lys Glu Cys Ser Ala Leu Gly Gly Leu Phe 
1               5                   10                  15      
Gln Thr Ile Ile Ser Asp Met Lys Gly Ser Tyr Pro Val Trp Glu Asp 
            20                  25                  30          
Phe Ile Asn Lys Ala Gly Lys Leu Gln Ser Gln Leu Arg Thr Thr Val 
        35                  40                  45              
Val Ala Ala Ala Ala Phe Leu Asp Ala Phe Gln Lys Val Ala Asp Met 
    50                  55                  60                  
Ala Thr Asn Thr Arg 
65                  

<210> 15
<211> 626
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..626
<223> /mol_type="mRNA"
      /note="NRG1"
      /organism="Homo sapiens"

<400> 15
ccuugccucc ccaauugaaa gagaugaaaa gccaggaauc ggcugcaggu uccaaacuag      60

uccuucggug ugaaaccagu ucugaauacu ccucucucag auucaagugg uucaagaaug     120

ggaaugaauu gaaucgaaaa aacaaaccac aaaauaucaa gauacaaaaa aagccaggga     180

agucagaacu ucgcauuaac aaagcaucac uggcugauuc uggagaguau augugcaaag     240

ugaucagcaa auuaggaaau gacagugccu cugccaauau caccaucgug gaaucaaacg     300

agaucaucac ugguaugcca gccucaacug aaggagcaua ugugucuuca gagucuccca     360

uuagaauauc aguauccaca gaaggagcaa auacuucuuc aucuacaucu acauccacca     420

cugggacaag ccaucuugua aaaugugcgg agaaggagaa aacuuucugu gugaauggag     480

gggagugcuu cauggugaaa gaccuuucaa accccucgag auacuugugc aagugcccaa     540

augaguuuac uggugaucgc ugccaaaacu acguaauggc cagcuucuac aguacgucca     600

cucccuuucu gucucugccu gaauag                                          626


<210> 16
<211> 208
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..208
<223> /mol_type="mRNA"
      /note="MTSS1"
      /organism="Homo sapiens"

<400> 16
auggaggcug ugauugagaa ggaaugcagc gcgcucggag gccucuucca gaccaucauc     60

agcgacauga aggggagcua uccaguuugg gaagauuuca uaaacaaagc aggaaagcug    120

cagucccagc uucggacaac aguaguagca gcagcugccu ucuuggacgc cuuucagaaa    180

guggcugaca uggccaccaa cacacgug                                       208


<210> 17
<211> 755
<212> PRT
<213> Homo sapiens

<220> 
<223> MTSS1

<400> 17
Met Glu Ala Val Ile Glu Lys Glu Cys Ser Ala Leu Gly Gly Leu Phe 
1               5                   10                  15      
Gln Thr Ile Ile Ser Asp Met Lys Gly Ser Tyr Pro Val Trp Glu Asp 
            20                  25                  30          
Phe Ile Asn Lys Ala Gly Lys Leu Gln Ser Gln Leu Arg Thr Thr Val 
        35                  40                  45              
Val Ala Ala Ala Ala Phe Leu Asp Ala Phe Gln Lys Val Ala Asp Met 
    50                  55                  60                  
Ala Thr Asn Thr Arg Gly Gly Thr Arg Glu Ile Gly Ser Ala Leu Thr 
65                  70                  75                  80  
Arg Met Cys Met Arg His Arg Ser Ile Glu Ala Lys Leu Arg Gln Phe 
                85                  90                  95      
Ser Ser Ala Leu Ile Asp Cys Leu Ile Asn Pro Leu Gln Glu Gln Met 
            100                 105                 110         
Glu Glu Trp Lys Lys Val Ala Asn Gln Leu Asp Lys Asp His Ala Lys 
        115                 120                 125             
Glu Tyr Lys Lys Ala Arg Gln Glu Ile Lys Lys Lys Ser Ser Asp Thr 
    130                 135                 140                 
Leu Lys Leu Gln Lys Lys Ala Lys Lys Gly Arg Gly Asp Ile Gln Pro 
145                 150                 155                 160 
Gln Leu Asp Ser Ala Leu Gln Asp Val Asn Asp Lys Tyr Leu Leu Leu 
                165                 170                 175     
Glu Glu Thr Glu Lys Gln Ala Val Arg Lys Ala Leu Ile Glu Glu Arg 
            180                 185                 190         
Gly Arg Phe Cys Thr Phe Ile Ser Met Leu Arg Pro Val Ile Glu Glu 
        195                 200                 205             
Glu Ile Ser Met Leu Gly Glu Ile Thr His Leu Gln Thr Ile Ser Glu 
    210                 215                 220                 
Asp Leu Lys Ser Leu Thr Met Asp Pro His Lys Leu Pro Ser Ser Ser 
225                 230                 235                 240 
Glu Gln Val Ile Leu Asp Leu Lys Gly Ser Asp Tyr Ser Trp Ser Tyr 
                245                 250                 255     
Gln Thr Pro Pro Ser Ser Pro Ser Thr Thr Met Ser Arg Lys Ser Ser 
            260                 265                 270         
Val Cys Ser Ser Leu Asn Ser Val Asn Ser Ser Asp Ser Arg Ser Ser 
        275                 280                 285             
Gly Ser His Ser His Ser Pro Ser Ser His Tyr Arg Tyr Arg Ser Ser 
    290                 295                 300                 
Asn Leu Ala Gln Gln Ala Pro Val Arg Leu Ser Ser Val Ser Ser His 
305                 310                 315                 320 
Asp Ser Gly Phe Ile Ser Gln Asp Ala Phe Gln Ser Lys Ser Pro Ser 
                325                 330                 335     
Pro Met Pro Pro Glu Ala Pro Asn Gln Leu Ser Asn Gly Phe Ser His 
            340                 345                 350         
Tyr Ser Leu Ser Ser Glu Ser His Val Gly Pro Thr Gly Ala Gly Leu 
        355                 360                 365             
Phe Pro His Cys Leu Pro Ala Ser Arg Leu Leu Pro Arg Val Thr Ser 
    370                 375                 380                 
Val His Leu Pro Asp Tyr Ala His Tyr Tyr Thr Ile Gly Pro Gly Met 
385                 390                 395                 400 
Phe Pro Ser Ser Gln Ile Pro Ser Trp Lys Asp Trp Ala Lys Pro Gly 
                405                 410                 415     
Pro Tyr Asp Gln Pro Leu Val Asn Thr Leu Gln Arg Arg Lys Glu Lys 
            420                 425                 430         
Arg Glu Pro Asp Pro Asn Gly Gly Gly Pro Thr Thr Ala Ser Gly Pro 
        435                 440                 445             
Pro Ala Ala Ala Glu Glu Ala Gln Arg Pro Arg Ser Met Thr Val Ser 
    450                 455                 460                 
Ala Ala Thr Arg Pro Gly Glu Glu Met Glu Ala Cys Glu Glu Leu Ala 
465                 470                 475                 480 
Leu Ala Leu Ser Arg Gly Leu Gln Leu Asp Thr Gln Arg Ser Ser Arg 
                485                 490                 495     
Asp Ser Leu Gln Cys Ser Ser Gly Tyr Ser Thr Gln Thr Thr Thr Pro 
            500                 505                 510         
Cys Cys Ser Glu Asp Thr Ile Pro Ser Gln Val Ser Asp Tyr Asp Tyr 
        515                 520                 525             
Phe Ser Val Ser Gly Asp Gln Glu Ala Asp Gln Gln Glu Phe Asp Lys 
    530                 535                 540                 
Ser Ser Thr Ile Pro Arg Asn Ser Asp Ile Ser Gln Ser Tyr Arg Arg 
545                 550                 555                 560 
Met Phe Gln Ala Lys Arg Pro Ala Ser Thr Ala Gly Leu Pro Thr Thr 
                565                 570                 575     
Leu Gly Pro Ala Met Val Thr Pro Gly Val Ala Thr Ile Arg Arg Thr 
            580                 585                 590         
Pro Ser Thr Lys Pro Ser Val Arg Arg Gly Thr Ile Gly Ala Gly Pro 
        595                 600                 605             
Ile Pro Ile Lys Thr Pro Val Ile Pro Val Lys Thr Pro Thr Val Pro 
    610                 615                 620                 
Asp Leu Pro Gly Val Leu Pro Ala Pro Pro Asp Gly Pro Glu Glu Arg 
625                 630                 635                 640 
Gly Glu His Ser Pro Glu Ser Pro Ser Val Gly Glu Gly Pro Gln Gly 
                645                 650                 655     
Val Thr Ser Met Pro Ser Ser Met Trp Ser Gly Gln Ala Ser Val Asn 
            660                 665                 670         
Pro Pro Leu Pro Gly Pro Lys Pro Ser Ile Pro Glu Glu His Arg Gln 
        675                 680                 685             
Ala Ile Pro Glu Ser Glu Ala Glu Asp Gln Glu Arg Glu Pro Pro Ser 
    690                 695                 700                 
Ala Thr Val Ser Pro Gly Gln Ile Pro Glu Ser Asp Pro Ala Asp Leu 
705                 710                 715                 720 
Ser Pro Arg Asp Thr Pro Gln Gly Glu Asp Met Leu Asn Ala Ile Arg 
                725                 730                 735     
Arg Gly Val Lys Leu Lys Lys Thr Thr Thr Asn Asp Arg Ser Ala Pro 
            740                 745                 750         
Arg Phe Ser 
        755 

<210> 18
<211> 2268
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2268
<223> /mol_type="mRNA"
      /note="MTSS1"
      /organism="Homo sapiens"

<400> 18
auggaggcug ugauugagaa ggaaugcagc gcgcucggag gccucuucca gaccaucauc      60

agcgacauga aggggagcua uccaguuugg gaagauuuca uaaacaaagc aggaaagcug     120

cagucccagc uucggacaac aguaguagca gcagcugccu ucuuggacgc cuuucagaaa     180

guggcugaca uggccaccaa cacacguggu gggaccaggg agauuggauc ugcucucacc     240

aggaugugca ugaggcacag aagcauugaa gccaagcuga ggcaguuuuc gagcgcuuua     300

auugauuguc ugauaaaccc acuucaagaa cagauggaag aauggaagaa aguggccaac     360

cagcuggaua aagaccacgc aaaagaauau aagaaagccc gccaagagau aaaaaagaag     420

uccucggaua cgcugaaacu gcagaagaaa gcaaaaaaag ggagagguga uauccagccu     480

caguuggaca gugcucucca agaugucaau gauaaguauc ucuuauugga agaaacagaa     540

aagcaggcug uccggaaggc uuugauugaa gaacguggcc gauucuguac cuucaucucu     600

augcugcggc cagugauuga agaagaaauc ucaaugcuag gggaaauaac ccaccuucag     660

accaucucgg aagaucuaaa aagccugacc auggacccuc acaaacugcc cuccucaagu     720

gaacagguga uucuggacuu gaaagguucu gauuacagcu ggucguauca gacgccaccc     780

ucuuccccca gcaccaccau guccagaaag uccagugucu gcagcagccu gaacaguguc     840

aacagcagug acucccgguc cagcggcucc cacucgcauu cccccagcuc acauuaccgc     900

uaccgcagcu ccaaccuggc ccagcaggcu ccugugaggc uguccagcgu guccucccau     960

gacucaggau ucauauccca ggaugccuuc caguccaagu caccaucccc caugccgcca    1020

gaggccccca accaguuguc uaacggguuu ucucacuaua guuuaucaag ugagucccac    1080

guggggccca cgggugcagg ccuuuucccu cauugccugc cugccucccg ccugcucccu    1140

cgggucaccu cuguccaccu uccagacuac gcucauuauu acaccauugg gcccggcaug    1200

uucccgucau cucagauccc uagcuggaag gacugggcua agccugggcc cuaugaccag    1260

ccucugguga acacccugca gcgccgcaaa gagaagcgag aaccggaccc caacggggga    1320

ggacccacua ccgccagcgg cccaccugca gcagcugagg aggcucagag accacggagc    1380

augacuguau cggcugccac caggccuggu gaggagaugg aggcuuguga ggagcuggcc    1440

cuggcccugu cucggggccu gcagcuggac acccagagga gcagccggga cucgcuucag    1500

ugcuccagcg gcuacagcac ccagacaacc acccccugcu gcucugagga caccaucccu    1560

ucccaaguuu cagauuauga uuauuucucu guaaguggug accaggaggc agaucagcag    1620

gaguucgaca aguccuccac cauuccaaga aacagcgaca ucagccaguc cuaccgacgg    1680

auguuccaag ccaagcgucc agccucaacu gcuggccucc ccaccacccu gggaccugcu    1740

auggucacuc cagggguugc aacuauccga cggaccccuu ccaccaagcc uucuguccgc    1800

cggggaacca uuggagcugg ucccaucccc aucaagacac ccgugauccc ugucaagacc    1860

ccaaccgucc cagaccuccc agggguguug ccagccccuc cagaugggcc agaagagcgg    1920

ggggagcaca gcccugaguc gccaucugug ggugagggcc cccaaggugu caccagcaug    1980

cccuccucaa uguggagcgg ccaagcuucc guuaacccuc cacuuccagg cccgaagccc    2040

aguaucccug aggagcacag acaggcaauu ccagaaagug aagcugaaga ccaggaacgg    2100

gaacccccaa gugccacugu cuccccaggc cagauuccag agagugaccc ugcagaccug    2160

agcccaaggg auacuccaca aggagaagac augcugaacg ccauccgaag gggcgugaaa    2220

cugaagaaga ccacgacaaa cgaucgcuca gccccucgcu uuucuuag                 2268


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="forward primer"
      /organism="Artificial Sequence"

<400> 19
cttcccggag aacctgagac                                                20


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="reverse primer"
      /organism="Artificial Sequence"

<400> 20
atctcgaggg gtttgaaagg                                                20


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="forward primer"
      /organism="Artificial Sequence"

<400> 21
cgctcggagg cctcttccag a                                              21


<210> 22
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /mol_type="unassigned DNA"
      /note="reverse primer"
      /organism="Artificial Sequence"

<400> 22
tgcgaagttc tgacttccct ggc                                            23


<210> 23
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..24
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 23
ctatggatcc atgcacagga ggag                                           24


<210> 24
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..34
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 24
gatcgtcgac ctattcaggc agagacagaa aggg                                 34


<210> 25
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 25
cctgtttgaa atgagcaggc actccttgga gcaaaagccc actgacgctc caccgaaagc     60

tacatctaca tccaccactg ggaca                                           85


<210> 26
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 26
tgtttgaaat gagcaggcac tccttggagc aaaagcccac tgacgctcca ccgaaagcta     60

catctacatc caccactggg acaag                                           85


<210> 27
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 27
gtttgaaatg agcaggcact ccttggagca aaagcccact gacgctccac cgaaagctac     60

atctacatcc accactggga caagc                                           85


<210> 28
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 28
tttgaaatga gcaggcactc cttggagcaa aagcccactg acgctccacc gaaagctaca     60

tctacatcca ccactgggac aagcc                                           85


<210> 29
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 29
tgaaatgagc aggccctcct tggagcaaaa gcccactgac gctccaccga aagctacatc     60

tacatccacc actgggacaa gccat                                           85


<210> 30
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 30
gaaatgagca ggcactcctt ggagcaaaag cccactgacg ctccaccgaa agctacatct     60

acatccacca ctgggacaag ccatc                                           85


<210> 31
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 31
aaatgagcag gcactccttg gagcaaaagc ccactgacgc tccaccgaaa gctacatcta     60

catccaccac tgggacaagc catct                                           85


<210> 32
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 32
aatgagcagg cactccttgg agcaaaagcc cactgacgct ccaccgaaag ctacatctac     60

atccaccact gggacaagcc atcta                                           85


<210> 33
<211> 85
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..85
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 33
atgagcaggc actccttgga gcaaaagccc actgacgctc caccgaaagc tacatctaca     60

ttcaccactg ggacaagcca tcttg                                           85


<210> 34
<211> 84
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..84
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 34
gcctttcaga aagtggctga catggccacc aacacacgtg ccttgcctcc ccaattgaaa     60

gagatgaaaa gccaggaatc ggct                                            84


<210> 35
<211> 28
<212> PRT
<213> Homo sapiens


<400> 35
Ala Phe Gln Lys Val Ala Asp Met Ala Thr Asn Thr Arg Ala Leu Pro 
1               5                   10                  15      
Pro Gln Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
            20                  25              

<210> 36
<211> 84
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..84
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<220> 
<221> variation
<222> 1..84
<223> /replace="a, t, g or c"

<400> 36
gcctttcaga aagtggctga catggccacc aacacacgng ccttgcctcc ccaattgaaa     60

gagatgaaaa nccaggaatn ggnt                                            84


<210> 37
<211> 28
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 1..28
<223> any naturally occuring amino acid

<400> 37
Ala Phe Gln Lys Val Ala Asp Met Ala Thr Asn Thr Arg Ala Leu Pro 
1               5                   10                  15      
Pro Gln Leu Lys Glu Met Lys Xaa Gln Glu Xaa Xaa 
            20                  25              

