                         SEQUENCE LISTING

<110>  University of Rochester
       Berk, Bradford C.
       Soe, Nwenwe
       Sowden, Mark
 
<120>  ANTIBODIES TO ACETYLATED CYCLOPHILIN A AND USE THEREOF

<130>  29556.3481 (6-2224)

<150>  61/863,709
<151>  2013-08-08

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  2
<211>  2276
<212>  DNA
<213>  Homo sapiens

<400>  2
gaacgtggta taaaaggggc gggaggccag gctcgtgccg ttttgcagac gccaccgccg       60

aggaaaaccg tgtactatta gccatggtca accccaccgt gttcttcgac attgccgtcg      120

acggcgagcc cttgggccgc gtctcctttg agctgtttgc agacaaggtc ccaaagacag      180

cagaaaattt tcgtgctctg agcactggag agaaaggatt tggttataag ggttcctgct      240

ttcacagaat tattccaggg tttatgtgtc agggtggtga cttcacacgc cataatggca      300

ctggtggcaa gtccatctat ggggagaaat ttgaagatga gaacttcatc ctaaagcata      360

cgggtcctgg catcttgtcc atggcaaatg ctggacccaa cacaaatggt tcccagtttt      420

tcatctgcac tgccaagact gagtggttgg atggcaagca tgtggtgttt ggcaaagtga      480

aagaaggcat gaatattgtg gaggccatgg agcgctttgg gtccaggaat ggcaagacca      540

gcaagaagat caccattgct gactgtggac aactcgaata agtttgactt gtgttttatc      600

ttaaccacca gatcattcct tctgtagctc aggagagcac ccctccaccc catttgctcg      660

cagtatccta gaatctttgt gctctcgctg cagttccctt tgggttccat gttttccttg      720

ttccctccca tgcctagctg gattgcagag ttaagtttat gattatgaaa taaaaactaa      780

ataacaattg tcctcgtttg agttaagagt gttgatgtag gctttatttt aagcagtaat      840

gggttacttc tgaaacatca cttgtttgct taattctaca cagtacttag atttttttta      900

ctttccagtc ccaggaagtg tcaatgtttg ttgagtggaa tattgaaaat gtaggcagca      960

actgggcatg gtggctcact gtctgtaatg tattacctga ggcagaagac cacctgaggg     1020

taggagtcaa gatcagcctg ggcaacatag tgagacgctg tctctacaaa aaataattag     1080

cctggcctgg tggtgcatgc ctagtcctag ctgatctgga ggctgacgtg ggaggattgc     1140

ttgagcctag agtgagctat tatcatgcca ctgtacagcc tgggtgttca cagatcttgt     1200

gtctcaaagg taggcagagg caggaaaagc aaggagccag aattaagagg ttgggtcagt     1260

ctgcagtgag ttcatgcatt tagaggtgtt cttcaagatg actaatgtca aaaattgaga     1320

catctgttgc ggtttttttt tttttttttt cccctggaat gcagtggcgt gatctcagct     1380

cactgcagcc tccgcctcct gggttcaagt gattctagtg cctcagcctc ctgagtagct     1440

gggataatgg gcgtgtgcca ccatgcccag ctaatttttg tatttttagt atagatgggg     1500

tttcatcatt ttgaccaggc tggtctcaaa ctcttgacct cagctgatgc gcctgccttg     1560

gcctcccaaa ctgctgagat tacagatgtg agccaccgca ccctacctca ttttctgtaa     1620

caaagctaag cttgaacact gttgatgttc ttgagggaag catattgggc tttaggctgt     1680

aggtcaagtt tatacatctt aattatggtg gaattcctat gtagagtcta aaaagccagg     1740

tacttggtgc tacagtcagt ctccctgcag agggttaagg cgcagactac ctgcagtgag     1800

gaggtactgc ttgtagcata tagagcctct ccctagcttt ggttatggag gctttgaggt     1860

tttgcaaacc tgaccaattt aagccataag atctggtcaa agggataccc ttcccactaa     1920

ggacttggtt tctcaggaaa ttatatgtac agtgcttgct ggcagttaga tgtcaggaca     1980

atctaagctg agaaaacccc ttctctgccc accttaacag acctctaggg ttcttaaccc     2040

agcaatcaag tttgcctatc ctagaggtgg cggatttgat catttggtgt gttgggcaat     2100

ttttgtttta ctgtctggtt ccttctgcgt gaattaccac caccaccact tgtgcatctc     2160

agtcttgtgt gttgtctggt tacgtattcc ctgggtgata ccattcaatg tcttaatgta     2220

cttgtggctc agacctgagt gcaaggtgga aataaacatc aaacatcttt tcatta         2276


<210>  3
<211>  164
<212>  PRT
<213>  Mus musculus

<400>  3

Met Val Asn Pro Thr Val Phe Phe Asp Ile Thr Ala Asp Asp Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Ser Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Arg Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ser Asp 
145                 150                 155                 160 


Cys Gly Gln Leu 
                


<210>  4
<211>  495
<212>  DNA
<213>  Mus musculus

<400>  4
atggtcaacc ccaccgtgtt cttcgacatc acggccgatg acgagccctt gggccgcgtc       60

tccttcgagc tgtttgcaga caaagttcca aagacagcag aaaactttcg agctctgagc      120

actggagaga aaggatttgg ctataagggt tcctcctttc acagaattat tccaggattc      180

atgtgccagg gtggtgactt tacacgccat aatggcactg gcggcaggtc catctacgga      240

gagaaatttg aggatgagaa cttcatccta aagcatacag gtcctggcat cttgtccatg      300

gcaaatgctg gaccaaacac aaacggttcc cagtttttta tctgcactgc caagactgaa      360

tggctggatg gcaagcatgt ggtctttggg aaggtgaaag aaggcatgaa tattgtggaa      420

gccatggagc gttttgggtc caggaatggc aagaccagca agaagatcac catttccgac      480

tgtggacagc tctaa                                                       495


<210>  5
<211>  164
<212>  PRT
<213>  Rattus rattus

<400>  5

Met Val Asn Pro Thr Val Phe Phe Asp Ile Thr Ala Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Cys Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Ser Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Ser Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ser Asp 
145                 150                 155                 160 


Cys Gly Gln Leu 
                


<210>  6
<211>  740
<212>  DNA
<213>  Rattus rattus

<400>  6
tcgccgcttg ctgcagacat ggtcaacccc accgtgttct tcgacatcac ggctgatggc       60

gagcccttgg gtcgcgtctg cttcgagctg tttgcagaca aagttccaaa gacagcagaa      120

aactttcgtg ctctgagcac tggggagaaa ggatttggct ataagggttc ctcctttcac      180

agaattattc caggattcat gtgccagggt ggtgacttca cacgccataa tggcactggt      240

ggcaagtcca tctacggaga gaaatttgag gatgagaact tcatcctgaa gcatacaggt      300

cctggcatct tgtccatggc aaatgctgga ccaaacacaa atggttccca gttttttatc      360

tgcactgcca agactgagtg gctggatggc aagcatgtgg tctttgggaa ggtgaaagaa      420

ggcatgagca ttgtggaagc catggagcgt tttgggtcca ggaatggcaa gaccagcaag      480

aagatcacca tctccgactg tggacaactc taatttcttt gacttgcggg cattttaccc      540

atcaaaccat tccttctgta gctcaggaga gcacccccac cccatctgct cgcaataccc      600

tgtaatctct gctctcactg aagttctttg ggttccatat tttcctcatt ccccttcaag      660

tctagcagga ttgcaaagtt aagtttatga ttatgaataa aaactaaatg agaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa                                                  740


<210>  7
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  AcK-CyPA Epitope, K82

<400>  7

Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile 
1               5                   10              


<210>  8
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  AcK-CyPA Epitope, K125

<400>  8

Thr Glu Trp Leu Asp Gly Lys Phe Glu Asp Glu Asn Phe Ile 
1               5                   10                  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CypA K125 NT

<400>  9

Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val 
1               5                   10                  15      


<210>  10
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CypA K125 CT

<400>  10

Thr Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val 
1               5                   10                  


<210>  11
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CypA K82 NT

<400>  11

Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CypA K82 CT

<400>  12

Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile 
1               5                   10              


<210>  13
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CyPA K125 NP

<400>  13

Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val 
1               5                   10                  15      


<210>  14
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CyPA K82 NP

<400>  14

Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile 
1               5                   10              


<210>  15
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer K44R F

<400>  15
gcactgggga gagaggattt ggctataag                                         29


<210>  16
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer K44R R

<400>  16
cttatagcca aatcctctct ccccagtgc                                         29


<210>  17
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer K82R F

<400>  17
ccatctacgg agagagattt gaggatgaga ac                                     32


<210>  18
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer K82R R

<400>  18
gttctcatcc tcaaatctct ctccgtagat gg                                     32


<210>  19
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Primer K125R F

<400>  19
gtggcttggc aggcatgtgg tctttgg                                           27


<210>  20
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer K125R R

<400>  20
ccaaagacca catgcctgcc atccagccac                                        30


