                         SEQUENCE LISTING

<110>  Chen, Janice
       Shi, Shuangpint
 
<120>  METHODS AND COMPOSITIONS FOR CO-EXPRESSION OF POLYPEPTIDES OF 
       INTEREST AND IL6

<130>  23562

<150>  61/864,809
<151>  2013-08-12

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  639
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(639)

<400>  1
atg aac tcc ttc tcc aca agc gcc ttc ggt cca gtt gcc ttc tcc ctg         48
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu           
1               5                   10                  15                

ggg ctg ctc ctg gtg ttg cct gct gcc ttc cct gcc cca gta ccc cca         96
Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro           
            20                  25                  30                    

gga gaa gat tcc aaa gat gta gcc gcc cca cac aga cag cca ctc acc        144
Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr           
        35                  40                  45                        

tct tca gaa cga att gac aaa caa att cgg tac atc ctc gac ggc atc        192
Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile           
    50                  55                  60                            

tca gcc ctg aga aag gag aca tgt aac aag agt aac atg tgt gaa agc        240
Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser           
65                  70                  75                  80            

agc aaa gag gca ctg gca gaa aac aac ctg aac ctt cca aag atg gct        288
Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala           
                85                  90                  95                

gaa aaa gat gga tgc ttc caa tct gga ttc aat gag gag act tgc ctg        336
Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu           
            100                 105                 110                   

gtg aaa atc atc act ggt ctt ttg gag ttt gag gta tac cta gag tac        384
Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr           
        115                 120                 125                       

ctc cag aac aga ttt gag agt agt gag gaa caa gcc aga gct gtg cag        432
Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln           
    130                 135                 140                           

atg agt aca aaa gtc ctg atc cag ttc ctg cag aaa aag gca aag aat        480
Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn           
145                 150                 155                 160           

cta gat gca ata acc acc cct gac cca acc aca aat gcc agc ctg ctg        528
Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu           
                165                 170                 175               

acg aag ctg cag gca cag aac cag tgg ctg cag gac atg aca act cat        576
Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His           
            180                 185                 190                   

ctc att ctg cgc agc ttt aag gag ttc ctg cag tcc agc ctg agg gct        624
Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala           
        195                 200                 205                       

ctt cgg caa atg tag                                                    639
Leu Arg Gln Met                                                           
    210                                                                   


<210>  2
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  3
<211>  212
<212>  PRT
<213>  Cricetulus griseus

<400>  3

Met Lys Phe Leu Ser Ala Arg Asp Phe His Pro Leu Ala Phe Leu Gly 
1               5                   10                  15      


Leu Met Leu Ala Val Ala Thr Ala Leu Pro Thr Ser Gln Val Arg Arg 
            20                  25                  30          


Gly Asp Phe Thr Glu Asp Thr Thr Pro Asn Arg Pro Val Tyr Thr Thr 
        35                  40                  45              


Ser Gln Gln Val Gly Gly Leu Val Thr His Val Leu Arg Glu Ile Phe 
    50                  55                  60                  


Glu Leu Arg Lys Glu Leu Cys Asn Asn Asn Pro Asp Cys Met Asn Tyr 
65                  70                  75                  80  


Asp Asp Ala Leu Leu Glu Asn Asn Leu Glu Leu Pro Val Ile Gln Arg 
                85                  90                  95      


Asn Asp Gly Cys Tyr Gln Thr Gly Tyr Asn Trp Glu Ile Cys Leu Leu 
            100                 105                 110         


Lys Ile Thr Ser Gly Leu Leu Asp Tyr Gln Ile Tyr Leu Glu Phe Val 
        115                 120                 125             


Thr Asn Asn Val Gln Asp Asn Lys Lys Asp Lys Ala Arg Val Ile Gln 
    130                 135                 140                 


Ser Thr Thr Lys Thr Leu Ser Gln Ile Phe Lys Gln Glu Val Lys Asp 
145                 150                 155                 160 


Pro Asp Lys Ile Val Met Pro Ser Pro Thr Ser Lys Ala Ile Leu Ile 
                165                 170                 175     


Glu Lys Leu Glu Ser Gln Lys Gln Trp Pro Arg Thr Lys Thr Ile Glu 
            180                 185                 190         


Leu Ile Leu Lys Ala Leu Glu Glu Phe Leu Lys Val Thr Met Arg Ser 
        195                 200                 205             


Thr Arg Gln Asn 
    210         


<210>  4
<211>  211
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Lys Phe Leu Ser Ala Arg Asp Phe Gln Pro Val Ala Phe Leu Gly 
1               5                   10                  15      


Leu Met Leu Leu Thr Ala Thr Ala Phe Pro Thr Ser Gln Val Arg Arg 
            20                  25                  30          


Gly Asp Phe Thr Glu Asp Thr Thr His Asn Arg Pro Val Tyr Thr Thr 
        35                  40                  45              


Ser Gln Val Gly Gly Leu Ile Thr Tyr Val Leu Arg Glu Ile Leu Glu 
    50                  55                  60                  


Met Arg Lys Glu Leu Cys Asn Gly Asn Ser Asp Cys Met Asn Ser Asp 
65                  70                  75                  80  


Asp Ala Leu Ser Glu Asn Asn Leu Lys Leu Pro Glu Ile Gln Arg Asn 
                85                  90                  95      


Asp Gly Cys Phe Gln Thr Gly Tyr Asn Gln Glu Ile Cys Leu Leu Lys 
            100                 105                 110         


Ile Cys Ser Gly Leu Leu Glu Phe Arg Phe Tyr Leu Glu Phe Val Lys 
        115                 120                 125             


Asn Asn Leu Gln Asp Asn Lys Lys Asp Lys Ala Arg Val Ile Gln Ser 
    130                 135                 140                 


Asn Thr Glu Thr Leu Val His Ile Phe Lys Gln Glu Ile Lys Asp Ser 
145                 150                 155                 160 


Tyr Lys Ile Val Leu Pro Thr Pro Thr Ser Asn Ala Leu Leu Met Glu 
                165                 170                 175     


Lys Leu Glu Ser Gln Lys Glu Trp Leu Arg Thr Lys Thr Ile Gln Leu 
            180                 185                 190         


Ile Leu Lys Ala Leu Glu Glu Phe Leu Lys Val Thr Met Arg Ser Thr 
        195                 200                 205             


Arg Gln Thr 
    210     


<210>  5
<211>  194
<212>  PRT
<213>  Mus musculus

<400>  5

Met Leu Val Thr Thr Thr Ala Phe Pro Thr Ser Gln Val Arg Arg Gly 
1               5                   10                  15      


Asp Phe Thr Glu Asp Thr Thr His Asn Arg Pro Val Tyr Thr Thr Ser 
            20                  25                  30          


Gln Val Gly Gly Leu Ile Thr His Val Leu Trp Glu Ile Val Glu Met 
        35                  40                  45              


Arg Lys Glu Leu Cys Asn Gly Asn Ser Asp Cys Met Asn Asn Asp Asp 
    50                  55                  60                  


Ala Leu Ala Glu Asn Asn Leu Lys Leu Pro Glu Ile Gln Arg Asn Asp 
65                  70                  75                  80  


Gly Cys Tyr Gln Thr Gly Tyr Asn Gln Glu Ile Cys Leu Leu Lys Ile 
                85                  90                  95      


Ser Ser Gly Leu Leu Glu Tyr His Ser Tyr Leu Glu Tyr Met Lys Asn 
            100                 105                 110         


Asn Leu Lys Asp Asn Lys Lys Asp Lys Ala Arg Val Leu Gln Arg Asp 
        115                 120                 125             


Thr Glu Thr Leu Ile His Ile Phe Asn Gln Glu Val Lys Asp Leu His 
    130                 135                 140                 


Lys Ile Val Leu Pro Thr Pro Ile Ser Asn Ala Leu Leu Thr Asp Lys 
145                 150                 155                 160 


Leu Glu Ser Gln Lys Glu Trp Leu Arg Thr Lys Thr Ile Gln Phe Ile 
                165                 170                 175     


Leu Lys Ser Leu Glu Glu Phe Leu Lys Val Thr Leu Arg Ser Thr Arg 
            180                 185                 190         


Gln Thr 
        


<210>  6
<211>  212
<212>  PRT
<213>  Pan troglodytes

<400>  6

Met Asn Ser Val Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  7
<211>  212
<212>  PRT
<213>  Gorilla gorilla gorilla

<400>  7

Met Asn Ser Val Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Val Gly Asn 
145                 150                 155                 160 


Leu Asp Val Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  8
<211>  212
<212>  PRT
<213>  Macaca mulatta

<400>  8

Met Asn Ser Val Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Leu Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Ser Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys His Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Arg Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Asp Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Glu Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


