                               SEQUENCE LISTING

<110> ALEXION PHARMACEUTICALS, INC.
 
<120> TREATMENT OF GRAFT REJECTION BY ADMINISTERING A COMPLEMENT 
      INHIBITOR TO AN ORGAN PRIOR TO TRANSPLANT

<130> AXJ-188PC

<140> PCT/US14/51323
<141> 2014-08-15

<150> 61/867,009
<151> 2013-08-16

<160> 42    

<170> PatentIn version 3.5

<210> 1
<211> 1087
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Arg Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Gly Cys Gln Pro Pro Pro Gly Leu His His Gly Arg His 
            660                 665                 670         


Thr Gly Gly Asn Thr Val Phe Phe Val Ser Gly Met Thr Val Asp Tyr 
        675                 680                 685             


Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Asn Lys Ser Ile His Cys 
    690                 695                 700                 


Met Pro Ser Gly Asn Trp Ser Pro Ser Ala Pro Arg Cys Glu Glu Thr 
705                 710                 715                 720 


Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg 
                725                 730                 735     


Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly Tyr Gln Leu Thr Gly 
            740                 745                 750         


His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys 
        755                 760                 765             


Lys Ile Pro Leu Cys Lys Val Ile His Cys His Pro Pro Pro Val Ile 
    770                 775                 780                 


Val Asn Gly Lys His Thr Gly Met Met Ala Glu Asn Phe Leu Tyr Gly 
785                 790                 795                 800 


Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe Tyr Leu Leu Gly Glu 
                805                 810                 815     


Lys Asn Cys Ser Ala Glu Val Ile Leu Lys Ala Trp Ile Leu Glu Arg 
            820                 825                 830         


Ala Phe Pro Gln Cys Leu Arg Ser Leu Cys Pro Asn Pro Glu Val Lys 
        835                 840                 845             


His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala Tyr Ser His Asn Asp 
    850                 855                 860                 


Ile Val Tyr Val Asp Cys Asn Pro Gly Phe Ile Met Asn Gly Ser Arg 
865                 870                 875                 880 


Val Ile Arg Cys His Thr Asp Asn Thr Trp Val Pro Gly Val Pro Thr 
                885                 890                 895     


Cys Ile Lys Lys Ala Phe Ile Gly Cys Pro Pro Pro Pro Lys Thr Pro 
            900                 905                 910         


Asn Gly Asn His Thr Gly Gly Asn Ile Ala Arg Phe Ser Pro Gly Met 
        915                 920                 925             


Ser Ile Leu Tyr Ser Cys Asp Gln Gly Tyr Leu Val Val Gly Glu Pro 
    930                 935                 940                 


Leu Leu Leu Cys Thr His Glu Gly Thr Trp Ser Gln Pro Ala Pro His 
945                 950                 955                 960 


Cys Lys Glu Val Asn Cys Ser Ser Pro Ala Asp Met Asp Gly Ile Gln 
                965                 970                 975     


Lys Gly Leu Glu Pro Arg Lys Met Tyr Gln Tyr Gly Ala Val Val Thr 
            980                 985                 990         


Leu Glu Cys Glu Asp Gly Tyr Met  Leu Glu Gly Ser Pro  Gln Ser Gln 
        995                 1000                 1005             


Cys Gln  Ser Asp His Gln Trp  Asn Pro Pro Leu Ala  Val Cys Arg 
    1010                 1015                 1020             


Ser Arg  Ser Leu Ala Pro Val  Leu Cys Gly Ile Ala  Ala Gly Leu 
    1025                 1030                 1035             


Ile Leu  Leu Thr Phe Leu Ile  Val Ile Thr Leu Tyr  Val Ile Ser 
    1040                 1045                 1050             


Lys His  Arg Glu Arg Asn Tyr  Tyr Thr Asp Thr Ser  Gln Lys Glu 
    1055                 1060                 1065             


Ala Phe  His Leu Glu Ala Arg  Glu Val Tyr Ser Val  Asp Pro Tyr 
    1070                 1075                 1080             


Asn Pro  Ala Ser 
    1085         


<210> 2
<211> 1231
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Arg Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210> 3
<211> 570
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid

<400> 3
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Ile Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr 
        115                 120                 125             


Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His 
    130                 135                 140                 


Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu 
145                 150                 155                 160 


Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys 
                165                 170                 175     


Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr 
            180                 185                 190         


Cys Glu Glu Ala Xaa Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys 
        195                 200                 205             


Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe 
    210                 215                 220                 


Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val 
225                 230                 235                 240 


Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Cys Val Ala Glu Asp Cys Asn Glu 
            260                 265                 270         


Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp 
        275                 280                 285             


Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly 
    290                 295                 300                 


Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp 
305                 310                 315                 320 


Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His 
                325                 330                 335     


Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val 
            340                 345                 350         


Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln 
        355                 360                 365             


Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr 
    370                 375                 380                 


Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala 
385                 390                 395                 400 


Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu 
                405                 410                 415     


Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys 
            420                 425                 430         


Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser 
        435                 440                 445             


Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val 
    450                 455                 460                 


Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu 
465                 470                 475                 480 


Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly 
                485                 490                 495     


Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu 
            500                 505                 510         


Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro 
        515                 520                 525             


Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg 
    530                 535                 540                 


Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser 
545                 550                 555                 560 


Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
                565                 570 


<210> 4
<211> 1711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
atttcttgtg gctctcctcc gcctatccta aatggccgga ttagttatta ttctaccccc       60

attgctgttg gtaccgtgat aaggtacagt tgttcaggta ccttccgcct cattggagaa      120

aaaagtctat tatgcataac taaagacaaa gtggatggaa cctgggataa acctgctcct      180

aaatgtgaat atttcaataa atattcttct tgccctgagc ccatagtacc aggaggatac      240

aaaattagag gctctacacc ctacagacat ggtgattctg tgacatttgc ctgtaaaacc      300

aacttctcca tgaacggaaa caagtctgtt tggtgtcaag caaataatat aaataatatg      360

tgggggccga cacgactacc aacctgtgta agtgttttcc ctctcgagtg tccagcactt      420

cctatgatcc acaatggaca tcacacaagt gagaatgttg gctccattgc tccaggattg      480

tctgtgactt acagctgtga atctggttac ttgcttgttg gagaaaagat cattaactgt      540

ttgtcttcgg gaaaatggag tgctgtcccc cccacatgtg aagaggcacs ctgtaaatct      600

ctaggacgat ttcccaatgg gaaggtaaag gagcctccaa ttctccgggt tggtgtaact      660

gcaaactttt tctgtgatga agggtatcga ctgcaaggcc caccttctag tcggtgtgta      720

attgctggac agggagttgc ttggaccaaa atgccagtat gtggcggagg tgggtcgggt      780

ggcggcggat cttgtgtagc agaagattgc aatgaacttc ctccaagaag aaatacagaa      840

attctgacag gttcctggtc tgaccaaaca tatccagaag gcacccaggc tatctataaa      900

tgccgccctg gatatagatc tcttggaaat gtaataatgg tatgcaggaa gggagaatgg      960

gttgctctta atccattaag gaaatgtcag aaaaggccct gtggacatcc tggagatact     1020

ccttttggta cttttaccct tacaggagga aatgtgtttg aatatggtgt aaaagctgtg     1080

tatacatgta atgaggggta tcaattgcta ggtgagatta attaccgtga atgtgacaca     1140

gatggatgga ccaatgatat tcctatatgt gaagttgtga agtgtttacc agtgacagca     1200

ccagagaatg gaaaaattgt cagtagtgca atggaaccag atcgggaata ccattttgga     1260

caagcagtac ggtttgtatg taactcaggc tacaagattg aaggagatga agaaatgcat     1320

tgttcagacg atggtttttg gagtaaagag aaaccaaagt gtgtggaaat ttcatgcaaa     1380

tccccagatg ttataaatgg atctcctata tctcagaaga ttatttataa ggagaatgaa     1440

cgatttcaat ataaatgtaa catgggttat gaatacagtg aaagaggaga tgctgtatgc     1500

actgaatctg gatggcgtcc gttgccttca tgtgaagaaa aatcatgtga taatccttat     1560

attccaaatg gtgactactc acctttaagg attaaacaca gaactggaga tgaaatcacg     1620

taccagtgta gaaatggttt ttatcctgca acccggggaa atacagccaa atgcacaagt     1680

actggctgga tacctgctcc gagatgtacc t                                    1711


<210> 5
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (252)..(254)
<223> Any amino acid

<400> 5
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr Cys Val Ser 
        115                 120                 125             


Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His Asn Gly His 
    130                 135                 140                 


His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu Ser Val Thr 
145                 150                 155                 160 


Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys Ile Ile Asn 
                165                 170                 175     


Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr Cys Glu Glu 
            180                 185                 190         


Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys Val Lys Glu 
        195                 200                 205             


Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe Cys Asp Glu 
    210                 215                 220                 


Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val Ile Ala Gly 
225                 230                 235                 240 


Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Xaa Xaa Xaa Cys Val 
                245                 250                 255     


Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu 
            260                 265                 270         


Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile 
        275                 280                 285             


Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val 
    290                 295                 300                 


Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln 
305                 310                 315                 320 


Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr 
                325                 330                 335     


Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr 
            340                 345                 350         


Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys 
        355                 360                 365             


Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys 
    370                 375                 380                 


Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala 
385                 390                 395                 400 


Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val 
                405                 410                 415     


Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser 
            420                 425                 430         


Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser 
        435                 440                 445             


Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile 
    450                 455                 460                 


Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr 
465                 470                 475                 480 


Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg 
                485                 490                 495     


Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro 
            500                 505                 510         


Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu 
        515                 520                 525             


Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn 
    530                 535                 540                 


Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
545                 550                 555                 560 


<210> 6
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (252)..(254)
<223> Any amino acid

<400> 6
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr Cys Val Ser 
        115                 120                 125             


Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His Asn Gly His 
    130                 135                 140                 


His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu Ser Val Thr 
145                 150                 155                 160 


Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys Ile Ile Asn 
                165                 170                 175     


Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr Cys Glu Glu 
            180                 185                 190         


Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys Val Lys Glu 
        195                 200                 205             


Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe Cys Asp Glu 
    210                 215                 220                 


Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val Ile Ala Gly 
225                 230                 235                 240 


Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Xaa Xaa Xaa Cys Val 
                245                 250                 255     


Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu 
            260                 265                 270         


Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile 
        275                 280                 285             


Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val 
    290                 295                 300                 


Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln 
305                 310                 315                 320 


Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr 
                325                 330                 335     


Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr 
            340                 345                 350         


Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys 
        355                 360                 365             


Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys 
    370                 375                 380                 


Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala 
385                 390                 395                 400 


Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val 
                405                 410                 415     


Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser 
            420                 425                 430         


Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser 
        435                 440                 445             


Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile 
    450                 455                 460                 


Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr 
465                 470                 475                 480 


Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg 
                485                 490                 495     


Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro 
            500                 505                 510         


Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu 
        515                 520                 525             


Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn 
    530                 535                 540                 


Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
545                 550                 555                 560 


<210> 7
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (255)..(257)
<223> Any amino acid

<400> 7
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Ile Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr 
        115                 120                 125             


Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His 
    130                 135                 140                 


Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu 
145                 150                 155                 160 


Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys 
                165                 170                 175     


Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr 
            180                 185                 190         


Cys Glu Glu Ala Xaa Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys 
        195                 200                 205             


Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe 
    210                 215                 220                 


Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val 
225                 230                 235                 240 


Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Xaa Xaa 
                245                 250                 255     


Xaa Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu 
            260                 265                 270         


Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile 
        275                 280                 285             


Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val 
    290                 295                 300                 


Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln 
305                 310                 315                 320 


Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr 
                325                 330                 335     


Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr 
            340                 345                 350         


Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys 
        355                 360                 365             


Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys 
    370                 375                 380                 


Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala 
385                 390                 395                 400 


Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val 
                405                 410                 415     


Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser 
            420                 425                 430         


Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser 
        435                 440                 445             


Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile 
    450                 455                 460                 


Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr 
465                 470                 475                 480 


Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg 
                485                 490                 495     


Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro 
            500                 505                 510         


Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu 
        515                 520                 525             


Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn 
    530                 535                 540                 


Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
545                 550                 555                 560 


<210> 8
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (255)..(257)
<223> Any amino acid

<400> 8
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Ile Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr 
        115                 120                 125             


Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His 
    130                 135                 140                 


Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu 
145                 150                 155                 160 


Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys 
                165                 170                 175     


Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr 
            180                 185                 190         


Cys Glu Glu Ala Xaa Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys 
        195                 200                 205             


Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe 
    210                 215                 220                 


Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val 
225                 230                 235                 240 


Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Xaa Xaa 
                245                 250                 255     


Xaa Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu 
            260                 265                 270         


Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile 
        275                 280                 285             


Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val 
    290                 295                 300                 


Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln 
305                 310                 315                 320 


Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr 
                325                 330                 335     


Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr 
            340                 345                 350         


Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys 
        355                 360                 365             


Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys 
    370                 375                 380                 


Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala 
385                 390                 395                 400 


Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val 
                405                 410                 415     


Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser 
            420                 425                 430         


Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser 
        435                 440                 445             


Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile 
    450                 455                 460                 


Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr 
465                 470                 475                 480 


Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg 
                485                 490                 495     


Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro 
            500                 505                 510         


Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu 
        515                 520                 525             


Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn 
    530                 535                 540                 


Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
545                 550                 555                 560 


<210> 9
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (252)..(254)
<223> Any amino acid

<400> 9
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr Cys Val Ser 
        115                 120                 125             


Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His Asn Gly His 
    130                 135                 140                 


His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu Ser Val Thr 
145                 150                 155                 160 


Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys Ile Ile Asn 
                165                 170                 175     


Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr Cys Glu Glu 
            180                 185                 190         


Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys Val Lys Glu 
        195                 200                 205             


Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe Cys Asp Glu 
    210                 215                 220                 


Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val Ile Ala Gly 
225                 230                 235                 240 


Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Xaa Xaa Xaa Glu Asp 
                245                 250                 255     


Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser 
            260                 265                 270         


Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys 
        275                 280                 285             


Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg Lys 
    290                 295                 300                 


Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro 
305                 310                 315                 320 


Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly 
                325                 330                 335     


Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn Glu 
            340                 345                 350         


Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp 
        355                 360                 365             


Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu Pro 
    370                 375                 380                 


Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu Pro 
385                 390                 395                 400 


Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn Ser 
                405                 410                 415     


Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp Gly 
            420                 425                 430         


Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys Ser 
        435                 440                 445             


Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys 
    450                 455                 460                 


Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser 
465                 470                 475                 480 


Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro 
                485                 490                 495     


Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp 
            500                 505                 510         


Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr Tyr 
        515                 520                 525             


Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys 
    530                 535                 540                 


Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
545                 550                 555         


<210> 10
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (252)..(254)
<223> Any amino acid

<400> 10
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr Cys Val Ser 
        115                 120                 125             


Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His Asn Gly His 
    130                 135                 140                 


His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu Ser Val Thr 
145                 150                 155                 160 


Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys Ile Ile Asn 
                165                 170                 175     


Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr Cys Glu Glu 
            180                 185                 190         


Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys Val Lys Glu 
        195                 200                 205             


Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe Cys Asp Glu 
    210                 215                 220                 


Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val Ile Ala Gly 
225                 230                 235                 240 


Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Xaa Xaa Xaa Glu Asp 
                245                 250                 255     


Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser 
            260                 265                 270         


Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys 
        275                 280                 285             


Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys Arg Lys 
    290                 295                 300                 


Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro 
305                 310                 315                 320 


Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly 
                325                 330                 335     


Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn Glu 
            340                 345                 350         


Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp 
        355                 360                 365             


Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu Pro 
    370                 375                 380                 


Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu Pro 
385                 390                 395                 400 


Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn Ser 
                405                 410                 415     


Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp Gly 
            420                 425                 430         


Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys Ser 
        435                 440                 445             


Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys 
    450                 455                 460                 


Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser 
465                 470                 475                 480 


Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro 
                485                 490                 495     


Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp 
            500                 505                 510         


Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr Tyr 
        515                 520                 525             


Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys 
    530                 535                 540                 


Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
545                 550                 555         


<210> 11
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser 
            20      


<210> 12
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
atgcccatgg ggtctctgca accgctggcc accttgtacc tgctggggat gctggtcgct       60

tcctgcctcg ga                                                           72


<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly 
    


<210> 14
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
atgggcgccg cgggcctgct cggggttttc ttggctctcg tcgcaccggg ggtcctcggg       60


<210> 15
<211> 1025
<212> PRT
<213> Mus sp.

<400> 15
Met Leu Thr Trp Phe Leu Phe Tyr Phe Ser Glu Ile Ser Cys Asp Pro 
1               5                   10                  15      


Pro Pro Glu Val Lys Asn Ala Arg Lys Pro Tyr Tyr Ser Leu Pro Ile 
            20                  25                  30          


Val Pro Gly Thr Val Leu Arg Tyr Thr Cys Ser Pro Ser Tyr Arg Leu 
        35                  40                  45              


Ile Gly Glu Lys Ala Ile Phe Cys Ile Ser Glu Asn Gln Val His Ala 
    50                  55                  60                  


Thr Trp Asp Lys Ala Pro Pro Ile Cys Glu Ser Val Asn Lys Thr Ile 
65                  70                  75                  80  


Ser Cys Ser Asp Pro Ile Val Pro Gly Gly Phe Met Asn Lys Gly Ser 
                85                  90                  95      


Lys Ala Pro Phe Arg His Gly Asp Ser Val Thr Phe Thr Cys Lys Ala 
            100                 105                 110         


Asn Phe Thr Met Lys Gly Ser Lys Thr Val Trp Cys Gln Ala Asn Glu 
        115                 120                 125             


Met Trp Gly Pro Thr Ala Leu Pro Val Cys Glu Ser Asp Phe Pro Leu 
    130                 135                 140                 


Glu Cys Pro Ser Leu Pro Thr Ile His Asn Gly His His Thr Gly Gln 
145                 150                 155                 160 


His Val Asp Gln Phe Val Ala Gly Leu Ser Val Thr Tyr Ser Cys Glu 
                165                 170                 175     


Pro Gly Tyr Leu Leu Thr Gly Lys Lys Thr Ile Lys Cys Leu Ser Ser 
            180                 185                 190         


Gly Asp Trp Asp Gly Val Ile Pro Thr Cys Lys Glu Ala Gln Cys Glu 
        195                 200                 205             


His Pro Gly Lys Phe Pro Asn Gly Gln Val Lys Glu Pro Leu Ser Leu 
    210                 215                 220                 


Gln Val Gly Thr Thr Val Tyr Phe Ser Cys Asn Glu Gly Tyr Gln Leu 
225                 230                 235                 240 


Gln Gly Gln Pro Ser Ser Gln Cys Val Ile Val Glu Gln Lys Ala Ile 
                245                 250                 255     


Trp Thr Lys Lys Pro Val Cys Lys Glu Ile Leu Cys Pro Pro Pro Pro 
            260                 265                 270         


Pro Val Arg Asn Gly Ser His Thr Gly Ser Phe Ser Glu Asn Val Pro 
        275                 280                 285             


Tyr Gly Ser Thr Val Thr Tyr Thr Cys Asp Pro Ser Pro Glu Lys Gly 
    290                 295                 300                 


Val Ser Phe Thr Leu Ile Gly Glu Lys Thr Ile Asn Cys Thr Thr Gly 
305                 310                 315                 320 


Ser Gln Lys Thr Gly Ile Trp Ser Gly Pro Ala Pro Tyr Cys Val Leu 
                325                 330                 335     


Ser Thr Ser Ala Val Leu Cys Leu Gln Pro Lys Ile Lys Arg Gly Gln 
            340                 345                 350         


Ile Leu Ser Ile Leu Lys Asp Ser Tyr Ser Tyr Asn Asp Thr Val Ala 
        355                 360                 365             


Phe Ser Cys Glu Pro Gly Phe Thr Leu Lys Gly Asn Arg Ser Ile Arg 
    370                 375                 380                 


Cys Asn Ala His Gly Thr Trp Glu Pro Pro Val Pro Val Cys Glu Lys 
385                 390                 395                 400 


Gly Cys Gln Ala Pro Pro Lys Ile Ile Asn Gly Gln Lys Glu Asp Ser 
                405                 410                 415     


Tyr Leu Leu Asn Phe Asp Pro Gly Thr Ser Ile Arg Tyr Ser Cys Asp 
            420                 425                 430         


Pro Gly Tyr Leu Leu Val Gly Glu Asp Thr Ile His Cys Thr Pro Glu 
        435                 440                 445             


Gly Lys Trp Thr Pro Ile Thr Pro Gln Cys Thr Val Ala Glu Cys Lys 
    450                 455                 460                 


Pro Val Gly Pro His Leu Phe Lys Arg Pro Gln Asn Gln Phe Ile Arg 
465                 470                 475                 480 


Thr Ala Val Asn Ser Ser Cys Asp Glu Gly Phe Gln Leu Ser Glu Ser 
                485                 490                 495     


Ala Tyr Gln Leu Cys Gln Gly Thr Ile Pro Trp Phe Ile Glu Ile Arg 
            500                 505                 510         


Leu Cys Lys Glu Ile Thr Cys Pro Pro Pro Pro Val Ile His Asn Gly 
        515                 520                 525             


Thr His Thr Trp Ser Ser Ser Glu Asp Val Pro Tyr Gly Thr Val Val 
    530                 535                 540                 


Thr Tyr Met Cys Tyr Pro Gly Pro Glu Glu Gly Val Lys Phe Lys Leu 
545                 550                 555                 560 


Ile Gly Glu Gln Thr Ile His Cys Thr Ser Asp Ser Arg Gly Arg Gly 
                565                 570                 575     


Ser Trp Ser Ser Pro Ala Pro Leu Cys Lys Leu Ser Leu Pro Ala Val 
            580                 585                 590         


Gln Cys Thr Asp Val His Val Glu Asn Gly Val Lys Leu Thr Asp Asn 
        595                 600                 605             


Lys Ala Pro Tyr Phe Tyr Asn Asp Ser Val Met Phe Lys Cys Asp Asp 
    610                 615                 620                 


Gly Tyr Ile Leu Ser Gly Ser Ser Gln Ile Arg Cys Lys Ala Asn Asn 
625                 630                 635                 640 


Thr Trp Asp Pro Glu Lys Pro Leu Cys Lys Lys Glu Gly Cys Glu Pro 
                645                 650                 655     


Met Arg Val His Gly Leu Pro Asp Asp Ser His Ile Lys Leu Val Lys 
            660                 665                 670         


Arg Thr Cys Gln Asn Gly Tyr Gln Leu Thr Gly Tyr Thr Tyr Glu Lys 
        675                 680                 685             


Cys Gln Asn Ala Glu Asn Gly Thr Trp Phe Lys Lys Ile Glu Val Cys 
    690                 695                 700                 


Thr Val Ile Leu Cys Gln Pro Pro Pro Lys Ile Ala Asn Gly Gly His 
705                 710                 715                 720 


Thr Gly Met Met Ala Lys His Phe Leu Tyr Gly Asn Glu Val Ser Tyr 
                725                 730                 735     


Glu Cys Asp Glu Gly Phe Tyr Leu Leu Gly Glu Lys Ser Leu Gln Cys 
            740                 745                 750         


Val Asn Asp Ser Lys Gly His Gly Ser Trp Ser Gly Pro Pro Pro Gln 
        755                 760                 765             


Cys Leu Gln Ser Ser Pro Leu Thr His Cys Pro Asp Pro Glu Val Lys 
    770                 775                 780                 


His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala Phe Ser His Asn Asp 
785                 790                 795                 800 


Ile Val His Phe Val Cys Asn Gln Gly Phe Ile Met Asn Gly Ser His 
                805                 810                 815     


Leu Ile Arg Cys His Thr Asn Asn Thr Trp Leu Pro Gly Val Pro Thr 
            820                 825                 830         


Cys Ile Arg Lys Ala Ser Leu Gly Cys Gln Ser Pro Ser Thr Ile Pro 
        835                 840                 845             


Asn Gly Asn His Thr Gly Gly Ser Ile Ala Arg Phe Pro Pro Gly Met 
    850                 855                 860                 


Ser Val Met Tyr Ser Cys Tyr Gln Gly Phe Leu Met Ala Gly Glu Ala 
865                 870                 875                 880 


Arg Leu Ile Cys Thr His Glu Gly Thr Trp Ser Gln Pro Pro Pro Phe 
                885                 890                 895     


Cys Lys Glu Val Asn Cys Ser Phe Pro Glu Asp Thr Asn Gly Ile Gln 
            900                 905                 910         


Lys Gly Phe Gln Pro Gly Lys Thr Tyr Arg Phe Gly Ala Thr Val Thr 
        915                 920                 925             


Leu Glu Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Gln Ser Gln 
    930                 935                 940                 


Cys Gln Asp Asp Ser Gln Trp Asn Pro Pro Leu Ala Leu Cys Lys Tyr 
945                 950                 955                 960 


Arg Arg Trp Ser Thr Ile Pro Leu Ile Cys Gly Ile Ser Val Gly Ser 
                965                 970                 975     


Ala Leu Ile Ile Leu Met Ser Val Gly Phe Cys Met Ile Leu Lys His 
            980                 985                 990         


Arg Glu Ser Asn Tyr Tyr Thr Lys  Thr Arg Pro Lys Glu  Gly Ala Leu 
        995                 1000                 1005             


His Leu  Glu Thr Arg Glu Val  Tyr Ser Ile Asp Pro  Tyr Asn Pro 
    1010                 1015                 1020             


Ala Ser  
    1025 


<210> 16
<211> 1249
<212> PRT
<213> Mus sp.

<400> 16
Met Arg Leu Ser Ala Arg Ile Ile Trp Leu Ile Leu Trp Thr Val Cys 
1               5                   10                  15      


Ala Ala Glu Asp Cys Lys Gly Pro Pro Pro Arg Glu Asn Ser Glu Ile 
            20                  25                  30          


Leu Ser Gly Ser Trp Ser Glu Gln Leu Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Thr Tyr Lys Cys Arg Pro Gly Tyr Arg Thr Leu Gly Thr Ile Val Lys 
    50                  55                  60                  


Val Cys Lys Asn Gly Lys Trp Val Ala Ser Asn Pro Ser Arg Ile Cys 
65                  70                  75                  80  


Arg Lys Lys Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Ser Phe 
                85                  90                  95      


Arg Leu Ala Val Gly Ser Gln Phe Glu Phe Gly Ala Lys Val Val Tyr 
            100                 105                 110         


Thr Cys Asp Asp Gly Tyr Gln Leu Leu Gly Glu Ile Asp Tyr Arg Glu 
        115                 120                 125             


Cys Gly Ala Asp Gly Trp Ile Asn Asp Ile Pro Leu Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Glu Leu Glu Asn Gly Arg Ile Val Ser Gly 
145                 150                 155                 160 


Ala Ala Glu Thr Asp Gln Glu Tyr Tyr Phe Gly Gln Val Val Arg Phe 
                165                 170                 175     


Glu Cys Asn Ser Gly Phe Lys Ile Glu Gly His Lys Glu Ile His Cys 
            180                 185                 190         


Ser Glu Asn Gly Leu Trp Ser Asn Glu Lys Pro Arg Cys Val Glu Ile 
        195                 200                 205             


Leu Cys Thr Pro Pro Arg Val Glu Asn Gly Asp Gly Ile Asn Val Lys 
    210                 215                 220                 


Pro Val Tyr Lys Glu Asn Glu Arg Tyr His Tyr Lys Cys Lys His Gly 
225                 230                 235                 240 


Tyr Val Pro Lys Glu Arg Gly Asp Ala Val Cys Thr Gly Ser Gly Trp 
                245                 250                 255     


Ser Ser Gln Pro Phe Cys Glu Glu Lys Arg Cys Ser Pro Pro Tyr Ile 
            260                 265                 270         


Leu Asn Gly Ile Tyr Thr Pro His Arg Ile Ile His Arg Ser Asp Asp 
        275                 280                 285             


Glu Ile Arg Tyr Glu Cys Asn Tyr Gly Phe Tyr Pro Val Thr Gly Ser 
    290                 295                 300                 


Thr Val Ser Lys Cys Thr Pro Thr Gly Trp Ile Pro Val Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Glu Phe Pro Gln Phe Lys Tyr Gly Arg Leu Tyr 
                325                 330                 335     


Tyr Glu Glu Ser Leu Arg Pro Asn Phe Pro Val Ser Ile Gly Asn Lys 
            340                 345                 350         


Tyr Ser Tyr Lys Cys Asp Asn Gly Phe Ser Pro Pro Ser Gly Tyr Ser 
        355                 360                 365             


Trp Asp Tyr Leu Arg Cys Thr Ala Gln Gly Trp Glu Pro Glu Val Pro 
    370                 375                 380                 


Cys Val Arg Lys Cys Val Phe His Tyr Val Glu Asn Gly Asp Ser Ala 
385                 390                 395                 400 


Tyr Trp Glu Lys Val Tyr Val Gln Gly Gln Ser Leu Lys Val Gln Cys 
                405                 410                 415     


Tyr Asn Gly Tyr Ser Leu Gln Asn Gly Gln Asp Thr Met Thr Cys Thr 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Pro Pro Lys Cys Ile Arg Ile Lys Thr Cys 
        435                 440                 445             


Ser Ala Ser Asp Ile His Ile Asp Asn Gly Phe Leu Ser Glu Ser Ser 
    450                 455                 460                 


Ser Ile Tyr Ala Leu Asn Arg Glu Thr Ser Tyr Arg Cys Lys Gln Gly 
465                 470                 475                 480 


Tyr Val Thr Asn Thr Gly Glu Ile Ser Gly Ser Ile Thr Cys Leu Gln 
                485                 490                 495     


Asn Gly Trp Ser Pro Gln Pro Ser Cys Ile Lys Ser Cys Asp Met Pro 
            500                 505                 510         


Val Phe Glu Asn Ser Ile Thr Lys Asn Thr Arg Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Lys Leu Asp Tyr Glu Cys Leu Val Gly Phe Glu Asn Glu Tyr 
    530                 535                 540                 


Lys His Thr Lys Gly Ser Ile Thr Cys Thr Tyr Tyr Gly Trp Ser Asp 
545                 550                 555                 560 


Thr Pro Ser Cys Tyr Glu Arg Glu Cys Ser Val Pro Thr Leu Asp Arg 
                565                 570                 575     


Lys Leu Val Val Ser Pro Arg Lys Glu Lys Tyr Arg Val Gly Asp Leu 
            580                 585                 590         


Leu Glu Phe Ser Cys His Ser Gly His Arg Val Gly Pro Asp Ser Val 
        595                 600                 605             


Gln Cys Tyr His Phe Gly Trp Ser Pro Gly Phe Pro Thr Cys Lys Gly 
    610                 615                 620                 


Gln Val Ala Ser Cys Ala Pro Pro Leu Glu Ile Leu Asn Gly Glu Ile 
625                 630                 635                 640 


Asn Gly Ala Lys Lys Val Glu Tyr Ser His Gly Glu Val Val Lys Tyr 
                645                 650                 655     


Asp Cys Lys Pro Arg Phe Leu Leu Lys Gly Pro Asn Lys Ile Gln Cys 
            660                 665                 670         


Val Asp Gly Asn Trp Thr Thr Leu Pro Val Cys Ile Glu Glu Glu Arg 
        675                 680                 685             


Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Ser Ala Lys Cys Ser 
    690                 695                 700                 


Val Pro Pro Tyr His His Gly Asp Ser Val Glu Phe Ile Cys Glu Glu 
705                 710                 715                 720 


Asn Phe Thr Met Ile Gly His Gly Ser Val Ser Cys Ile Ser Gly Lys 
                725                 730                 735     


Trp Thr Gln Leu Pro Lys Cys Val Ala Thr Asp Gln Leu Glu Lys Cys 
            740                 745                 750         


Arg Val Leu Lys Ser Thr Gly Ile Glu Ala Ile Lys Pro Lys Leu Thr 
        755                 760                 765             


Glu Phe Thr His Asn Ser Thr Met Asp Tyr Lys Cys Arg Asp Lys Gln 
    770                 775                 780                 


Glu Tyr Glu Arg Ser Ile Cys Ile Asn Gly Lys Trp Asp Pro Glu Pro 
785                 790                 795                 800 


Asn Cys Thr Ser Lys Thr Ser Cys Pro Pro Pro Pro Gln Ile Pro Asn 
                805                 810                 815     


Thr Gln Val Ile Glu Thr Thr Val Lys Tyr Leu Asp Gly Glu Lys Leu 
            820                 825                 830         


Ser Val Leu Cys Gln Asp Asn Tyr Leu Thr Gln Asp Ser Glu Glu Met 
        835                 840                 845             


Val Cys Lys Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Ile Glu Lys 
    850                 855                 860                 


Ile Pro Cys Ser Gln Pro Pro Thr Ile Glu His Gly Ser Ile Asn Leu 
865                 870                 875                 880 


Pro Arg Ser Ser Glu Glu Arg Arg Asp Ser Ile Glu Ser Ser Ser His 
                885                 890                 895     


Glu His Gly Thr Thr Phe Ser Tyr Val Cys Asp Asp Gly Phe Arg Ile 
            900                 905                 910         


Pro Glu Glu Asn Arg Ile Thr Cys Tyr Met Gly Lys Trp Ser Thr Pro 
        915                 920                 925             


Pro Arg Cys Val Gly Leu Pro Cys Gly Pro Pro Pro Ser Ile Pro Leu 
    930                 935                 940                 


Gly Thr Val Ser Leu Glu Leu Glu Ser Tyr Gln His Gly Glu Glu Val 
945                 950                 955                 960 


Thr Tyr His Cys Ser Thr Gly Phe Gly Ile Asp Gly Pro Ala Phe Ile 
                965                 970                 975     


Ile Cys Glu Gly Gly Lys Trp Ser Asp Pro Pro Lys Cys Ile Lys Thr 
            980                 985                 990         


Asp Cys Asp Val Leu Pro Thr Val  Lys Asn Ala Ile Ile  Arg Gly Lys 
        995                 1000                 1005             


Ser Lys  Lys Ser Tyr Arg Thr  Gly Glu Gln Val Thr  Phe Arg Cys 
    1010                 1015                 1020             


Gln Ser  Pro Tyr Gln Met Asn  Gly Ser Asp Thr Val  Thr Cys Val 
    1025                 1030                 1035             


Asn Ser  Arg Trp Ile Gly Gln  Pro Val Cys Lys Asp  Asn Ser Cys 
    1040                 1045                 1050             


Val Asp  Pro Pro His Val Pro  Asn Ala Thr Ile Val  Thr Arg Thr 
    1055                 1060                 1065             


Lys Asn  Lys Tyr Leu His Gly  Asp Arg Val Arg Tyr  Glu Cys Asn 
    1070                 1075                 1080             


Lys Pro  Leu Glu Leu Phe Gly  Gln Val Glu Val Met  Cys Glu Asn 
    1085                 1090                 1095             


Gly Ile  Trp Thr Glu Lys Pro  Lys Cys Arg Gly Leu  Phe Asp Leu 
    1100                 1105                 1110             


Ser Leu  Lys Pro Ser Asn Val  Phe Ser Leu Asp Ser  Thr Gly Lys 
    1115                 1120                 1125             


Cys Gly  Pro Pro Pro Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Leu 
    1130                 1135                 1140             


Ser Leu  Pro Val Tyr Glu Pro  Leu Ser Ser Val Glu  Tyr Gln Cys 
    1145                 1150                 1155             


Gln Lys  Tyr Tyr Leu Leu Lys  Gly Lys Lys Thr Ile  Thr Cys Thr 
    1160                 1165                 1170             


Asn Gly  Lys Trp Ser Glu Pro  Pro Thr Cys Leu His  Ala Cys Val 
    1175                 1180                 1185             


Ile Pro  Glu Asn Ile Met Glu  Ser His Asn Ile Ile  Leu Lys Trp 
    1190                 1195                 1200             


Arg His  Thr Glu Lys Ile Tyr  Ser His Ser Gly Glu  Asp Ile Glu 
    1205                 1210                 1215             


Phe Gly  Cys Lys Tyr Gly Tyr  Tyr Lys Ala Arg Asp  Ser Pro Pro 
    1220                 1225                 1230             


Phe Arg  Thr Lys Cys Ile Asn  Gly Thr Ile Asn Tyr  Pro Thr Cys 
    1235                 1240                 1245             


Val 
    


<210> 17
<211> 559
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Ile Ser Cys Asp Pro Pro Pro Glu Val Lys Asn Ala Arg Lys Pro Tyr 
1               5                   10                  15      


Tyr Ser Leu Pro Ile Val Pro Gly Thr Val Leu Arg Tyr Thr Cys Ser 
            20                  25                  30          


Pro Ser Tyr Arg Leu Ile Gly Glu Lys Ala Ile Phe Cys Ile Ser Glu 
        35                  40                  45              


Asn Gln Val His Ala Thr Trp Asp Lys Ala Pro Pro Ile Cys Glu Ser 
    50                  55                  60                  


Val Asn Lys Thr Ile Ser Cys Ser Asp Pro Ile Val Pro Gly Gly Phe 
65                  70                  75                  80  


Met Asn Lys Gly Ser Lys Ala Pro Phe Arg His Gly Asp Ser Val Thr 
                85                  90                  95      


Phe Thr Cys Lys Ala Asn Phe Thr Met Lys Gly Ser Lys Thr Val Trp 
            100                 105                 110         


Cys Gln Ala Asn Glu Met Trp Gly Pro Thr Ala Leu Pro Val Cys Glu 
        115                 120                 125             


Ser Asp Phe Pro Leu Glu Cys Pro Ser Leu Pro Thr Ile His Asn Gly 
    130                 135                 140                 


His His Thr Gly Gln His Val Asp Gln Phe Val Ala Gly Leu Ser Val 
145                 150                 155                 160 


Thr Tyr Ser Cys Glu Pro Gly Tyr Leu Leu Thr Gly Lys Lys Thr Ile 
                165                 170                 175     


Lys Cys Leu Ser Ser Gly Asp Trp Asp Gly Val Ile Pro Thr Cys Lys 
            180                 185                 190         


Glu Ala Gln Cys Glu His Pro Gly Lys Phe Pro Asn Gly Gln Val Lys 
        195                 200                 205             


Glu Pro Leu Ser Leu Gln Val Gly Thr Thr Val Tyr Phe Ser Cys Asn 
    210                 215                 220                 


Glu Gly Tyr Gln Leu Gln Gly Gln Pro Ser Ser Gln Cys Val Ile Val 
225                 230                 235                 240 


Glu Gln Lys Ala Ile Trp Thr Lys Lys Pro Val Cys Lys Glu Ile Leu 
                245                 250                 255     


Glu Asp Cys Lys Gly Pro Pro Pro Arg Glu Asn Ser Glu Ile Leu Ser 
            260                 265                 270         


Gly Ser Trp Ser Glu Gln Leu Tyr Pro Glu Gly Thr Gln Ala Thr Tyr 
        275                 280                 285             


Lys Cys Arg Pro Gly Tyr Arg Thr Leu Gly Thr Ile Val Lys Val Cys 
    290                 295                 300                 


Lys Asn Gly Lys Trp Val Ala Ser Asn Pro Ser Arg Ile Cys Arg Lys 
305                 310                 315                 320 


Lys Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Ser Phe Arg Leu 
                325                 330                 335     


Ala Val Gly Ser Gln Phe Glu Phe Gly Ala Lys Val Val Tyr Thr Cys 
            340                 345                 350         


Asp Asp Gly Tyr Gln Leu Leu Gly Glu Ile Asp Tyr Arg Glu Cys Gly 
        355                 360                 365             


Ala Asp Gly Trp Ile Asn Asp Ile Pro Leu Cys Glu Val Val Lys Cys 
    370                 375                 380                 


Leu Pro Val Thr Glu Leu Glu Asn Gly Arg Ile Val Ser Gly Ala Ala 
385                 390                 395                 400 


Glu Thr Asp Gln Glu Tyr Tyr Phe Gly Gln Val Val Arg Phe Glu Cys 
                405                 410                 415     


Asn Ser Gly Phe Lys Ile Glu Gly His Lys Glu Ile His Cys Ser Glu 
            420                 425                 430         


Asn Gly Leu Trp Ser Asn Glu Lys Pro Arg Cys Val Glu Ile Leu Cys 
        435                 440                 445             


Thr Pro Pro Arg Val Glu Asn Gly Asp Gly Ile Asn Val Lys Pro Val 
    450                 455                 460                 


Tyr Lys Glu Asn Glu Arg Tyr His Tyr Lys Cys Lys His Gly Tyr Val 
465                 470                 475                 480 


Pro Lys Glu Arg Gly Asp Ala Val Cys Thr Gly Ser Gly Trp Ser Ser 
                485                 490                 495     


Gln Pro Phe Cys Glu Glu Lys Arg Cys Ser Pro Pro Tyr Ile Leu Asn 
            500                 505                 510         


Gly Ile Tyr Thr Pro His Arg Ile Ile His Arg Ser Asp Asp Glu Ile 
        515                 520                 525             


Arg Tyr Glu Cys Asn Tyr Gly Phe Tyr Pro Val Thr Gly Ser Thr Val 
    530                 535                 540                 


Ser Lys Cys Thr Pro Thr Gly Trp Ile Pro Val Pro Arg Cys Thr 
545                 550                 555                 


<210> 18
<211> 1750
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 18
atgcccatgg ggtctctgca accgctggcc accttgtacc tgctggggat gctggtcgct       60

tccgtgctag cgatttcttg tgaccctcct cctgaagtca aaaatgctcg gaaaccctat      120

tattctcttc ccatagttcc tggaactgtt ctgaggtaca cttgttcacc tagctaccgc      180

ctcattggag aaaaggctat cttttgtata agtgaaaatc aagtgcatgc cacctgggat      240

aaagctcctc ctatatgtga atctgtgaat aaaaccattt cttgctcaga tcccatagta      300

ccagggggat tcatgaataa aggatctaag gcaccattca gacatggtga ttctgtgaca      360

tttacctgta aagccaactt caccatgaaa ggaagcaaaa ctgtctggtg ccaggcaaat      420

gaaatgtggg gaccaacagc tctgccagtc tgtgagagtg atttccctct ggagtgccca      480

tcacttccaa cgattcataa tggacaccac acaggacagc atgttgacca gtttgttgcg      540

gggttgtctg tgacatacag ttgtgaacct ggctatttgc tcactggaaa aaagacaatt      600

aagtgcttat cttcaggaga ctgggatggt gtcatcccga catgcaaaga ggcccagtgt      660

gaacatccag gaaagtttcc caatgggcag gtaaaggaac ctctgagcct tcaggttggc      720

acaactgtgt acttctcctg taatgaaggg taccaattac aaggacaacc ctctagtcag      780

tgtgtaattg ttgaacagaa agccatctgg actaagaagc cagtatgtaa agaaattctc      840

gaagattgta aaggtcctcc tccaagagaa aattcagaaa ttctctcagg ctcgtggtca      900

gaacaactat atccagaagg cacccaggct acctacaaat gccgccctgg ataccgaaca      960

cttggcacta ttgtaaaagt atgcaagaat ggaaaatggg tggcgtctaa cccatccagg     1020

atatgtcgga aaaagccttg tgggcatccc ggagacacac cctttgggtc ctttaggctg     1080

gcagttggat ctcaatttga gtttggtgca aaggttgttt atacctgtga tgatgggtat     1140

caactattag gtgaaattga ttaccgtgaa tgtggtgcag atggctggat caatgatatt     1200

ccactatgtg aagttgtgaa gtgtctacct gtgacagaac tcgagaatgg aagaattgtg     1260

agtggtgcag cagaaacaga ccaggaatac tattttggac aggtggtgcg gtttgaatgc     1320

aattcaggct tcaagattga aggacataag gaaattcatt gctcagaaaa tggcctttgg     1380

agcaatgaaa agccacgatg tgtggaaatt ctctgcacac caccgcgagt ggaaaatgga     1440

gatggtataa atgtgaaacc agtttacaag gagaatgaaa gataccacta taagtgtaag     1500

catggttatg tgcccaaaga aagaggggat gccgtctgca caggctctgg atggagttct     1560

cagcctttct gtgaagaaaa gagatgctca cctccttata ttctaaatgg tatctacaca     1620

cctcacagga ttatacacag aagtgatgat gaaatcagat atgaatgtaa ttatggcttc     1680

tatcctgtaa ctggatcaac tgtttcaaag tgtacaccca ctggctggat ccctgttcca     1740

agatgtacct                                                            1750


<210> 19
<211> 2676
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
gaattcgccg ccaccatgcc catggggtct ctgcaaccgc tggccacctt gtacctgctg       60

gggatgctgg tcgcttccgt gctagcgatt tcttgtgacc ctcctcctga agtcaaaaat      120

gctcggaaac cctattattc tcttcccata gttcctggaa ctgttctgag gtacacttgt      180

tcacctagct accgcctcat tggagaaaag gctatctttt gtataagtga aaatcaagtg      240

catgccacct gggataaagc tcctcctata tgtgaatctg tgaataaaac catttcttgc      300

tcagatccca tagtaccagg gggattcatg aataaaggat ctaaggcacc attcagacat      360

ggtgattctg tgacatttac ctgtaaagcc aacttcacca tgaaaggaag caaaactgtc      420

tggtgccagg caaatgaaat gtggggacca acagctctgc cagtctgtga gagtgatttc      480

cctctggagt gcccatcact tccaacgatt cataatggac accacacagg acagcatgtt      540

gaccagtttg ttgcggggtt gtctgtgaca tacagttgtg aacctggcta tttgctcact      600

ggaaaaaaga caattaagtg cttatcttca ggagactggg atggtgtcat cccgacatgc      660

aaagaggccc agtgtgaaca tccaggaaag tttcccaatg ggcaggtaaa ggaacctctg      720

agccttcagg ttggcacaac tgtgtacttc tcctgtaatg aagggtacca attacaagga      780

caaccctcta gtcagtgtgt aattgttgaa cagaaagcca tctggactaa gaagccagta      840

tgtaaagaaa ttctcgaaga ttgtaaaggt cctcctccaa gagaaaattc agaaattctc      900

tcaggctcgt ggtcagaaca actatatcca gaaggcaccc aggctaccta caaatgccgc      960

cctggatacc gaacacttgg cactattgta aaagtatgca agaatggaaa atgggtggcg     1020

tctaacccat ccaggatatg tcggaaaaag ccttgtgggc atcccggaga cacacccttt     1080

gggtccttta ggctggcagt tggatctcaa tttgagtttg gtgcaaaggt tgtttatacc     1140

tgtgatgatg ggtatcaact attaggtgaa attgattacc gtgaatgtgg tgcagatggc     1200

tggatcaatg atattccact atgtgaagtt gtgaagtgtc tacctgtgac agaactcgag     1260

aatggaagaa ttgtgagtgg tgcagcagaa acagaccagg aatactattt tggacaggtg     1320

gtgcggtttg aatgcaattc aggcttcaag attgaaggac ataaggaaat tcattgctca     1380

gaaaatggcc tttggagcaa tgaaaagcca cgatgtgtgg aaattctctg cacaccaccg     1440

cgagtggaaa atggagatgg tataaatgtg aaaccagttt acaaggagaa tgaaagatac     1500

cactataagt gtaagcatgg ttatgtgccc aaagaaagag gggatgccgt ctgcacaggc     1560

tctggatgga gttctcagcc tttctgtgaa gaaaagagat gctcacctcc ttatattcta     1620

aatggtatct acacacctca caggattata cacagaagtg atgatgaaat cagatatgaa     1680

tgtaattatg gcttctatcc tgtaactgga tcaactgttt caaagtgtac acccactggc     1740

tggatccctg ttccaagatg taccgaagat tgtaaaggtc ctcctccaag agaaaattca     1800

gaaattctct caggctcgtg gtcagaacaa ctatatccag aaggcaccca ggctacctac     1860

aaatgccgcc ctggataccg aacacttggc actattgtaa aagtatgcaa gaatggaaaa     1920

tgggtggcgt ctaacccatc caggatatgt cggaaaaagc cttgtgggca tcccggagac     1980

acaccctttg ggtcctttag gctggcagtt ggatctcaat ttgagtttgg tgcaaaggtt     2040

gtttatacct gtgatgatgg gtatcaacta ttaggtgaaa ttgattaccg tgaatgtggt     2100

gcagatggct ggatcaatga tattccacta tgtgaagttg tgaagtgtct acctgtgaca     2160

gaactcgaga atggaagaat tgtgagtggt gcagcagaaa cagaccagga atactatttt     2220

ggacaggtgg tgcggtttga atgcaattca ggcttcaaga ttgaaggaca taaggaaatt     2280

cattgctcag aaaatggcct ttggagcaat gaaaagccac gatgtgtgga aattctctgc     2340

acaccaccgc gagtggaaaa tggagatggt ataaatgtga aaccagttta caaggagaat     2400

gaaagatacc actataagtg taagcatggt tatgtgccca aagaaagagg ggatgccgtc     2460

tgcacaggct ctggatggag ttctcagcct ttctgtgaag aaaagagatg ctcacctcct     2520

tatattctaa atggtatcta cacacctcac aggattatac acagaagtga tgatgaaatc     2580

agatatgaat gtaattatgg cttctatcct gtaactggat caactgtttc aaagtgtaca     2640

cccactggct ggatccctgt tccaagatgt acctaa                               2676


<210> 20
<211> 2706
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
gaattcgccg ccaccatgcc catggggtct ctgcaaccgc tggccacctt gtacctgctg       60

gggatgctgg tcgcttccgt gctagcgatt tcttgtgacc ctcctcctga agtcaaaaat      120

gctcggaaac cctattattc tcttcccata gttcctggaa ctgttctgag gtacacttgt      180

tcacctagct accgcctcat tggagaaaag gctatctttt gtataagtga aaatcaagtg      240

catgccacct gggataaagc tcctcctata tgtgaatctg tgaataaaac catttcttgc      300

tcagatccca tagtaccagg gggattcatg aataaaggat ctaaggcacc attcagacat      360

ggtgattctg tgacatttac ctgtaaagcc aacttcacca tgaaaggaag caaaactgtc      420

tggtgccagg caaatgaaat gtggggacca acagctctgc cagtctgtga gagtgatttc      480

cctctggagt gcccatcact tccaacgatt cataatggac accacacagg acagcatgtt      540

gaccagtttg ttgcggggtt gtctgtgaca tacagttgtg aacctggcta tttgctcact      600

ggaaaaaaga caattaagtg cttatcttca ggagactggg atggtgtcat cccgacatgc      660

aaagaggccc agtgtgaaca tccaggaaag tttcccaatg ggcaggtaaa ggaacctctg      720

agccttcagg ttggcacaac tgtgtacttc tcctgtaatg aagggtacca attacaagga      780

caaccctcta gtcagtgtgt aattgttgaa cagaaagcca tctggactaa gaagccagta      840

tgtaaagaaa ttctcggcgg aggtgggtcg ggtggcggcg gatctgaaga ttgtaaaggt      900

cctcctccaa gagaaaattc agaaattctc tcaggctcgt ggtcagaaca actatatcca      960

gaaggcaccc aggctaccta caaatgccgc cctggatacc gaacacttgg cactattgta     1020

aaagtatgca agaatggaaa atgggtggcg tctaacccat ccaggatatg tcggaaaaag     1080

ccttgtgggc atcccggaga cacacccttt gggtccttta ggctggcagt tggatctcaa     1140

tttgagtttg gtgcaaaggt tgtttatacc tgtgatgatg ggtatcaact attaggtgaa     1200

attgattacc gtgaatgtgg tgcagatggc tggatcaatg atattccact atgtgaagtt     1260

gtgaagtgtc tacctgtgac agaactcgag aatggaagaa ttgtgagtgg tgcagcagaa     1320

acagaccagg aatactattt tggacaggtg gtgcggtttg aatgcaattc aggcttcaag     1380

attgaaggac ataaggaaat tcattgctca gaaaatggcc tttggagcaa tgaaaagcca     1440

cgatgtgtgg aaattctctg cacaccaccg cgagtggaaa atggagatgg tataaatgtg     1500

aaaccagttt acaaggagaa tgaaagatac cactataagt gtaagcatgg ttatgtgccc     1560

aaagaaagag gggatgccgt ctgcacaggc tctggatgga gttctcagcc tttctgtgaa     1620

gaaaagagat gctcacctcc ttatattcta aatggtatct acacacctca caggattata     1680

cacagaagtg atgatgaaat cagatatgaa tgtaattatg gcttctatcc tgtaactgga     1740

tcaactgttt caaagtgtac acccactggc tggatccctg ttccaagatg taccgaagat     1800

tgtaaaggtc ctcctccaag agaaaattca gaaattctct caggctcgtg gtcagaacaa     1860

ctatatccag aaggcaccca ggctacctac aaatgccgcc ctggataccg aacacttggc     1920

actattgtaa aagtatgcaa gaatggaaaa tgggtggcgt ctaacccatc caggatatgt     1980

cggaaaaagc cttgtgggca tcccggagac acaccctttg ggtcctttag gctggcagtt     2040

ggatctcaat ttgagtttgg tgcaaaggtt gtttatacct gtgatgatgg gtatcaacta     2100

ttaggtgaaa ttgattaccg tgaatgtggt gcagatggct ggatcaatga tattccacta     2160

tgtgaagttg tgaagtgtct acctgtgaca gaactcgaga atggaagaat tgtgagtggt     2220

gcagcagaaa cagaccagga atactatttt ggacaggtgg tgcggtttga atgcaattca     2280

ggcttcaaga ttgaaggaca taaggaaatt cattgctcag aaaatggcct ttggagcaat     2340

gaaaagccac gatgtgtgga aattctctgc acaccaccgc gagtggaaaa tggagatggt     2400

ataaatgtga aaccagttta caaggagaat gaaagatacc actataagtg taagcatggt     2460

tatgtgccca aagaaagagg ggatgccgtc tgcacaggct ctggatggag ttctcagcct     2520

ttctgtgaag aaaagagatg ctcacctcct tatattctaa atggtatcta cacacctcac     2580

aggattatac acagaagtga tgatgaaatc agatatgaat gtaattatgg cttctatcct     2640

gtaactggat caactgtttc aaagtgtaca cccactggct ggatccctgt tccaagatgt     2700

acctaa                                                                2706


<210> 21
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr Cys Val Ser 
        115                 120                 125             


Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His Asn Gly His 
    130                 135                 140                 


His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu Ser Val Thr 
145                 150                 155                 160 


Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys Ile Ile Asn 
                165                 170                 175     


Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr Cys Glu Glu 
            180                 185                 190         


Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys Val Lys Glu 
        195                 200                 205             


Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe Cys Asp Glu 
    210                 215                 220                 


Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val Ile Ala Gly 
225                 230                 235                 240 


Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu Glu Ile Phe Glu 
                245                 250                 255     


Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly 
            260                 265                 270         


Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys 
        275                 280                 285             


Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg 
    290                 295                 300                 


Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg 
305                 310                 315                 320 


Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr 
                325                 330                 335     


Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn 
            340                 345                 350         


Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr 
        355                 360                 365             


Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu 
    370                 375                 380                 


Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu 
385                 390                 395                 400 


Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn 
                405                 410                 415     


Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp 
            420                 425                 430         


Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys 
        435                 440                 445             


Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr 
    450                 455                 460                 


Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr 
465                 470                 475                 480 


Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu 
                485                 490                 495     


Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly 
            500                 505                 510         


Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr 
        515                 520                 525             


Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala 
    530                 535                 540                 


Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu Lys 
545                 550                 555                 560 


<210> 22
<211> 1755
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
gccgccacca tgggagccgc tggtctgctc ggcgtgttcc tcgccttggt ggcacctggc       60

gtcctgggca tcagctgcgg ttcccctcca ccaatcctga atggcagaat ctcctattac      120

tccacaccaa tcgccgtcgg cactgtgatc agatacagct gttcagggac ttttcggctg      180

atcggcgaga aaagcctcct ctgcattacc aaggataagg tcgatgggac atgggataaa      240

ccagctccta agtgcgagta cttcaataag tatagttcat gtccagagcc cattgttcct      300

ggtggctaca agattcgggg gagcacaccc tatcgccacg gtgactcagt gacctttgct      360

tgtaaaacca acttctcaat gaacggtaat aagtcagtgt ggtgtcaggc caataatatg      420

tggggtccta cacgactccc cacctgtgtg tccgtgttcc ccttggaatg ccccgccctg      480

cccatgatcc ataatggaca ccacaccagc gagaatgtcg ggagtatcgc acctggattg      540

agtgtcacct actcatgcga gtctggctac ctgcttgtag gtgaaaaaat tattaattgc      600

ttgtcctccg gcaaatggag tgccgttccc ccaacttgtg aagaggcccg gtgcaaatcc      660

ctcggccgct tccctaatgg taaagttaaa gagcctccaa tcctcagagt gggggtgacc      720

gctaacttct tctgtgatga aggctaccgg ttgcagggac cacccagtag ccggtgtgtc      780

atagctgggc agggagtggc ttggacaaag atgcccgttt gtgaggaaat cttcgaagac      840

tgtaatgagc tgcccccaag acggaataca gagatcctca caggctcttg gtccgatcaa      900

acttatccag agggtaccca ggcaatttac aagtgcagac ctggatacag gagcctgggc      960

aatgtgatta tggtgtgccg caagggggag tgggtggccc ttaatcctct ccggaagtgt     1020

cagaaaagac catgcggaca ccctggagat acacctttcg gtacctttac ccttaccggc     1080

ggcaatgtct tcgagtatgg cgtcaaggcc gtgtacactt gtaacgaggg ataccagctg     1140

ctgggggaaa taaactatcg tgagtgtgac actgacgggt ggactaacga catccccatt     1200

tgcgaggtgg tcaagtgcct tcctgtaacc gctcccgaaa atggtaagat cgtatcttcc     1260

gcaatggagc ctgatcggga ataccacttt ggacaagccg ttcggttcgt atgtaattca     1320

gggtataaaa ttgagggcga tgaggagatg cactgcagtg atgacggctt ttggtcaaag     1380

gaaaagccaa agtgcgtaga gatcagttgt aagtctcctg acgttattaa cgggagtccc     1440

atcagtcaga agatcattta caaggaaaac gagaggttcc agtataaatg caatatggga     1500

tatgagtact ccgaaagagg ggacgccgtg tgcacagagt ccggatggcg acctttgcca     1560

tcttgtgaag aaaagtcttg tgacaacccc tatattccta acggagatta ctctcctctg     1620

cgcatcaagc accgaactgg ggacgagatc acttaccaat gtcgaaacgg cttctaccct     1680

gctaccagag gtaacactgc caagtgtacc agcaccggtt ggattcccgc ccccagatgc     1740

acacttaaat gataa                                                      1755


<210> 23
<211> 863
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr Cys Val Ser 
        115                 120                 125             


Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His Asn Gly His 
    130                 135                 140                 


His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu Ser Val Thr 
145                 150                 155                 160 


Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys Ile Ile Asn 
                165                 170                 175     


Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr Cys Glu Glu 
            180                 185                 190         


Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys Val Lys Glu 
        195                 200                 205             


Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe Cys Asp Glu 
    210                 215                 220                 


Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val Ile Ala Gly 
225                 230                 235                 240 


Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu Glu Ile Phe Glu 
                245                 250                 255     


Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly 
            260                 265                 270         


Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys 
        275                 280                 285             


Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg 
    290                 295                 300                 


Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg 
305                 310                 315                 320 


Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr 
                325                 330                 335     


Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn 
            340                 345                 350         


Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr 
        355                 360                 365             


Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu 
    370                 375                 380                 


Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu 
385                 390                 395                 400 


Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn 
                405                 410                 415     


Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp 
            420                 425                 430         


Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys 
        435                 440                 445             


Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr 
    450                 455                 460                 


Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr 
465                 470                 475                 480 


Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu 
                485                 490                 495     


Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly 
            500                 505                 510         


Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr 
        515                 520                 525             


Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala 
    530                 535                 540                 


Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Glu Asp 
545                 550                 555                 560 


Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser 
                565                 570                 575     


Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys 
            580                 585                 590         


Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg Lys 
        595                 600                 605             


Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro 
    610                 615                 620                 


Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly 
625                 630                 635                 640 


Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn Glu 
                645                 650                 655     


Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp 
            660                 665                 670         


Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu Pro 
        675                 680                 685             


Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu Pro 
    690                 695                 700                 


Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn Ser 
705                 710                 715                 720 


Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp Gly 
                725                 730                 735     


Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys Ser 
            740                 745                 750         


Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys 
        755                 760                 765             


Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser 
    770                 775                 780                 


Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro 
785                 790                 795                 800 


Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp 
                805                 810                 815     


Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr Tyr 
            820                 825                 830         


Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys 
        835                 840                 845             


Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu Lys 
    850                 855                 860             


<210> 24
<211> 2665
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 24
cgccgccacc atgggcgcag caggcttgtt gggcgtgttc ctggcattgg tggcacccgg       60

cgtattgggc atttcatgcg gctctcctcc acccattctc aatggaagga tctcctacta      120

cagcaccccc atagctgtcg gcaccgttat ccgatacagt tgttccggta ctttccggct      180

tatcggcgaa aagtctttgc tgtgcattac caaggataaa gtggacggga cttgggacaa      240

acccgcacct aagtgcgagt attttaacaa atatagcagc tgccctgagc ctatagtacc      300

cggggggtat aaaatccggg gctctactcc ctatcgtcat ggcgattctg tgaccttcgc      360

atgtaaaact aatttttcaa tgaatggcaa caagtctgta tggtgtcaag caaataacat      420

gtggggacct acccgcctgc caacctgtgt gtcagtgttt cccctggaat gtccagccct      480

ccctatgatc cacaacggac atcacaccag cgaaaacgtt ggatccatcg caccagggct      540

ctctgtgact tactcttgcg agtccgggta cctgctcgtg ggtgaaaaga tcatcaactg      600

cctcagtagt ggtaaatggt ccgccgtgcc tcccacatgt gaagaggccc ggtgcaagag      660

cctgggccgg ttccccaacg gaaaagtgaa ggaacctcct atcttgaggg ttggtgtgac      720

cgctaacttt ttctgcgacg aggggtacag gctccaaggg cctccctcta gtcggtgcgt      780

aatcgccggt caaggagtcg catggactaa gatgcctgtg tgtgaggaga ttttcgagga      840

ttgtaatgaa ttgccaccca ggagaaatac tgaaatcctg acaggctctt ggtctgatca      900

gacttatcca gaaggcaccc aggccattta caagtgtcgg cctggataca gatctctggg      960

aaatgtgatc atggtatgta ggaaaggaga gtgggtggct ttgaaccccc tccgcaagtg     1020

tcagaaaaga ccatgcgggc atcctggaga caccccattc gggacattta cactgacagg     1080

cggaaacgta tttgagtacg gagtcaaggc cgtttataca tgtaacgaag ggtatcaact     1140

gctgggagaa atcaactata gggagtgcga cactgacgga tggacaaacg acattccaat     1200

ctgcgaagtg gtgaaatgtc ttccagttac agcccctgaa aacgggaaaa tcgtgtcctc     1260

cgctatggag cctgaccggg aatatcattt cggccaggcc gttagattcg tgtgtaatag     1320

cggctacaaa atcgagggcg acgaagaaat gcattgcagc gatgacgggt tctggagcaa     1380

ggagaagcct aaatgcgtcg aaatttcatg caagagtccc gacgtcataa acggttctcc     1440

aatttcccag aagatcattt ataaggagaa tgagcggttc cagtataagt gtaatatggg     1500

ctacgagtac agcgaacgcg gtgacgccgt gtgtaccgaa agtggctgga gaccactgcc     1560

tagttgcgag gagaaatcct gcgacaaccc ttatattccc aacggggact actctcctct     1620

gagaatcaag catcggactg gcgacgagat tacttaccaa tgcaggaacg gattctatcc     1680

agcaactcgg ggcaataccg ctaagtgtac ctccacaggc tggatacccg ctcctagatg     1740

tacagaggac tgcaatgaac tgccacctcg gcgcaataca gaaattttga ctggatcatg     1800

gtctgaccag acttaccccg agggcaccca ggccatctac aaatgtaggc ccggttatcg     1860

aagtttgggt aacgtgatta tggtgtgtcg aaaaggtgaa tgggtagcac tcaatcccct     1920

ccgtaaatgc cagaagcgtc cttgtgggca cccaggcgat accccttttg gaactttcac     1980

cctgactgga ggaaacgtct ttgaatatgg tgtgaaagcc gtgtacacat gcaatgaagg     2040

gtaccaactg ctcggagaga taaactatcg ggagtgcgat acagatggat ggaccaatga     2100

tataccaatc tgcgaggtgg tgaagtgtct cccagtcacc gctcctgaga acggaaagat     2160

cgtcagttct gctatggaac ctgacaggga ataccacttt gggcaagccg tccgcttcgt     2220

gtgcaattca gggtacaaga tagaaggcga cgaagagatg cactgttccg acgatggttt     2280

ctggtctaag gagaagccta aatgtgtcga gattagctgc aagtctcccg atgttattaa     2340

cggctctccc atctctcaaa aaattattta taaggaaaac gaaagatttc agtacaagtg     2400

caatatgggt tatgagtaca gtgaacgtgg agacgccgtg tgcacagagt ccgggtggcg     2460

tccactgccc agctgcgaag aaaaatcctg tgacaacccc tacatcccca atggcgacta     2520

ttcccccctg cgcatcaaac atcgtactgg cgatgaaatt acttaccagt gccgcaacgg     2580

gttctaccct gccacccggg gtaacacagc caaatgcacc tccaccggat ggatccccgc     2640

cccacgctgt accttgaaat gatga                                           2665


<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly 
            20  


<210> 26
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 26
atgggagccg ctggtctgct cggcgtgttc ctcgccttgg tggcacctgg cgtcctgggc       60


<210> 27
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn Tyr Trp Ile Gln Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Glu Ile Leu 
                165                 170                 175     


Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe Lys Asp Arg Val 
            180                 185                 190         


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
        195                 200                 205             


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Phe 
    210                 215                 220                 


Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210> 28
<211> 740
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 28
gatatccaga tgacccagtc cccgtcctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcg gcgccagcga aaacatctat ggcgcgctga actggtatca acagaaaccc      120

gggaaagctc cgaagcttct gatttacggt gcgacgaacc tggcagatgg agtcccttct      180

cgcttctctg gatccggctc cggaacggat ttcactctga ccatcagcag tctgcagcct      240

gaagacttcg ctacgtatta ctgtcagaac gttttaaata ctccgttgac tttcggacag      300

ggtaccaagg tggaaataaa acgtactggc ggtggtggtt ctggtggcgg tggatctggt      360

ggtggcggtt ctcaagtcca actggtgcaa tccggcgccg aggtcaagaa gccaggggcc      420

tcagtcaaag tgtcctgtaa agctagcggc tatatttttt ctaattattg gattcaatgg      480

gtgcgtcagg cccccgggca gggcctggaa tggatgggtg agatcttacc gggctctggt      540

agcaccgaat ataccgaaaa ttttaaagac cgtgttacta tgacgcgtga cacttcgact      600

agtacagtat acatggagct ctccagcctg cgatcggagg acacggccgt ctattattgc      660

gcgcgttatt tttttggttc tagcccgaat tggtattttg atgtttgggg tcaaggaacc      720

ctggtcactg tctcgagctg                                                  740


<210> 29
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly 
            20                  25                  30          


Ala Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        115                 120                 125             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn Tyr Trp Ile Gln 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Glu Ile 
                165                 170                 175     


Leu Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe Lys Asp Arg 
            180                 185                 190         


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu 
        195                 200                 205             


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr 
    210                 215                 220                 


Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210> 30
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210> 31
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Gly Gly Gly Gly Ser 
1               5   


<210> 33
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 34
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 35
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Ser Gly Gly Gly Gly 
1               5   


<210> 37
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210> 39
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly 
            20  


<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Val Ser Val Phe Pro Leu Glu 
1               5           


<210> 41
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Glu Glu Ile Phe 
1               


<210> 42
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Ser Phe Thr Leu 
1               


