                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Screening method

<130>  31257 WO

<150>  EP13180825.5
<151>  2013-08-19

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Phe Gly Glu Gln Val Val Phe Gly Tyr 
            420                 425                 430         


Met Ser Lys Phe Phe Ser Gly Asp Leu Arg Asp Phe Gly Thr Pro Ile 
        435                 440                 445             


Thr Ser Leu Phe Asn Phe Ile Phe Leu Cys Leu Ser Val Leu Leu Ala 
    450                 455                 460                 


Glu Glu Gly Ile Ala Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu 
465                 470                 475                 480 


Lys Leu Leu Phe Gly Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr 
                485                 490                 495     


Ile Lys Glu Glu Glu Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala 
            500                 505                 510         


Arg Pro Ile Lys Val Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro 
        515                 520                 525             


Ala Pro Ser Phe Lys Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser 
    530                 535                 540                 


Gln Ser Pro Thr Pro Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser 
545                 550                 555                 560 


Pro Thr Arg Cys Val Ser Glu Met Leu Val Ile Gln His Arg Glu Arg 
                565                 570                 575     


Arg Glu Arg Ser Arg Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys 
            580                 585                 590         


Val Asp Glu Pro Glu Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg 
        595                 600                 605             


Trp Ala Ala Glu Leu Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser 
    610                 615                 620                 


Gln Leu Ser Tyr Ser Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile 
625                 630                 635                 640 


Lys Glu Thr Leu Pro Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro 
                645                 650                 655     


Arg Thr Pro Glu Ser Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly 
            660                 665                 670         


Leu Asp Phe Ser Pro Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu 
        675                 680                 685             


Pro Asp Pro Leu Gly Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser 
    690                 695                 700                 


Ala Pro Pro Leu Glu Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu 
705                 710                 715                 720 


Asp Leu Ile Ser Val Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp 
                725                 730                 735     


Val Pro Lys Pro Gly Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala 
            740                 745                 750         


Asn Arg Ser Leu Thr Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser 
        755                 760                 765             


Leu Ser Lys Ile Leu Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp 
    770                 775                 780                 


Pro Leu Gly Pro Asp Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu 
785                 790                 795                 800 


Gln 
    


<210>  2
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Asp Gly Glu Ala Ala Gly Cys Thr Ile 
                165                 170                 175     


Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser Asp 
            180                 185                 190         


Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu Asn 
        195                 200                 205             


Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg Pro 
    210                 215                 220                 


Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser Tyr 
225                 230                 235                 240 


Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg Met 
                245                 250                 255     


Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr Phe 
            260                 265                 270         


Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn Leu 
        275                 280                 285             


Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys Val 
    290                 295                 300                 


Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu Asp 
305                 310                 315                 320 


Gln Val Phe Lys Gln Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg 
                325                 330                 335     


Asn Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met 
            340                 345                 350         


Lys Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe 
        355                 360                 365             


Pro Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu 
    370                 375                 380                 


Pro Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys 
385                 390                 395                 400 


Arg Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala 
                405                 410                 415     


Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly 
            420                 425                 430         


Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu 
        435                 440                 445             


Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val 
    450                 455                 460                 


Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys 
465                 470                 475                 480 


Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro 
                485                 490                 495     


Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val 
            500                 505                 510         


Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg 
        515                 520                 525             


Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu 
    530                 535                 540                 


Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu 
545                 550                 555                 560 


Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser 
                565                 570                 575     


Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro 
            580                 585                 590         


Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser 
        595                 600                 605             


Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro 
    610                 615                 620                 


Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly 
625                 630                 635                 640 


Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu 
                645                 650                 655     


Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val 
            660                 665                 670         


Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly 
        675                 680                 685             


Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr 
    690                 695                 700                 


Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu 
705                 710                 715                 720 


Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp 
                725                 730                 735     


Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
            740                 745             


<210>  3
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro 
            420                 425                 430         


Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu 
        435                 440                 445             


Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile 
    450                 455                 460                 


Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu 
465                 470                 475                 480 


Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu 
                485                 490                 495     


Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg 
            500                 505                 510         


Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser 
        515                 520                 525             


Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser 
    530                 535                 540                 


Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu 
545                 550                 555                 560 


Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro 
                565                 570                 575     


Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln 
            580                 585                 590         


Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile 
        595                 600                 605             


Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp 
    610                 615                 620                 


Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val 
625                 630                 635                 640 


Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu 
                645                 650                 655     


Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser 
            660                 665                 670         


Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro 
        675                 680                 685             


Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser 
    690                 695                 700                 


Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu 
705                 710                 715                 720 


Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu 
                725                 730                 735     


Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn 
            740                 745                 750         


Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
        755                 760             


<210>  4
<211>  3665
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (284)..(2689)

<400>  4
tttcaaacag cggaacaaac tgaaagctcc ggtgccagac cccacccccg gccccggccc       60

gggaccccct cccctcccgg gatcccccgg ggttcccacc ccgcccgcac cgccggggac      120

ccggccggtc cggcgcgagc ccccgtccgg ggccctggct cggcccccag gttggaggag      180

cccggagccc gccttcggag ctacggccta acggcggcgg cgactgcagt ctggagggtc      240

cacacttgtg attctcaatg gagagtgaaa acgcagattc ata atg aaa act agc        295
                                                Met Lys Thr Ser           
                                                1                         

ccc cgt cgg cca ctg att ctc aaa aga cgg agg ctg ccc ctt cct gtt        343
Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu Pro Leu Pro Val           
5                   10                  15                  20            

caa aat gcc cca agt gaa aca tca gag gag gaa cct aag aga tcc cct        391
Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro Lys Arg Ser Pro           
                25                  30                  35                

gcc caa cag gag tct aat caa gca gag gcc tcc aag gaa gtg gca gag        439
Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys Glu Val Ala Glu           
            40                  45                  50                    

tcc aac tct tgc aag ttt cca gct ggg atc aag att att aac cac ccc        487
Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile Ile Asn His Pro           
        55                  60                  65                        

acc atg ccc aac acg caa gta gtg gcc atc ccc aac aat gct aat att        535
Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn Asn Ala Asn Ile           
    70                  75                  80                            

cac agc atc atc aca gca ctg act gcc aag gga aaa gag agt ggc agt        583
His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys Glu Ser Gly Ser           
85                  90                  95                  100           

agt ggg ccc aac aaa ttc atc ctc atc agc tgt ggg gga gcc cca act        631
Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly Gly Ala Pro Thr           
                105                 110                 115               

cag cct cca gga ctc cgg cct caa acc caa acc agc tat gat gcc aaa        679
Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser Tyr Asp Ala Lys           
            120                 125                 130                   

agg aca gaa gtg acc ctg gag acc ttg gga cca aaa cct gca gct agg        727
Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys Pro Ala Ala Arg           
        135                 140                 145                       

gat gtg aat ctt cct aga cca cct gga gcc ctt tgc gag cag aaa cgg        775
Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys Glu Gln Lys Arg           
    150                 155                 160                           

gag acc tgt gca gat ggt gag gca gca ggc tgc act atc aac aat agc        823
Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr Ile Asn Asn Ser           
165                 170                 175                 180           

cta tcc aac atc cag tgg ctt cga aag atg agt tct gat gga ctg ggc        871
Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser Asp Gly Leu Gly           
                185                 190                 195               

tcc cgc agc atc aag caa gag atg gag gaa aag gag aat tgt cac ctg        919
Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu Asn Cys His Leu           
            200                 205                 210                   

gag cag cga cag gtt aag gtt gag gag cct tcg aga cca tca gcg tcc        967
Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg Pro Ser Ala Ser           
        215                 220                 225                       

tgg cag aac tct gtg tct gag cgg cca ccc tac tct tac atg gcc atg       1015
Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser Tyr Met Ala Met           
    230                 235                 240                           

ata caa ttc gcc atc aac agc act gag agg aag cgc atg act ttg aaa       1063
Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg Met Thr Leu Lys           
245                 250                 255                 260           

gac atc tat acg tgg att gag gac cac ttt ccc tac ttt aag cac att       1111
Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr Phe Lys His Ile           
                265                 270                 275               

gcc aag cca ggc tgg aag aac tcc atc cgc cac aac ctt tcc ctg cac       1159
Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His           
            280                 285                 290                   

gac atg ttt gtc cgg gag acg tct gcc aat ggc aag gtc tcc ttc tgg       1207
Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys Val Ser Phe Trp           
        295                 300                 305                       

acc att cac ccc agt gcc aac cgc tac ttg aca ttg gac cag gtg ttt       1255
Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu Asp Gln Val Phe           
    310                 315                 320                           

aag cca ctg gac cca ggg tct cca caa ttg ccc gag cac ttg gaa tca       1303
Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu His Leu Glu Ser           
325                 330                 335                 340           

cag cag aaa cga ccg aat cca gag ctc cgc cgg aac atg acc atc aaa       1351
Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn Met Thr Ile Lys           
                345                 350                 355               

acc gaa ctc ccc ctg ggc gca cgg cgg aag atg aag cca ctg cta cca       1399
Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys Pro Leu Leu Pro           
            360                 365                 370                   

cgg gtc agc tca tac ctg gta cct atc cag ttc ccg gtg aac cag tca       1447
Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro Val Asn Gln Ser           
        375                 380                 385                       

ctg gtg ttg cag ccc tcg gtg aag gtg cca ttg ccc ctg gcg gct tcc       1495
Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro Leu Ala Ala Ser           
    390                 395                 400                           

ctc atg agc tca gag ctt gcc cgc cat agc aag cga gtc cgc att gcc       1543
Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg Val Arg Ile Ala           
405                 410                 415                 420           

ccc aag gtt ttt ggg gaa cag gtg gtg ttt ggt tac atg agt aag ttc       1591
Pro Lys Val Phe Gly Glu Gln Val Val Phe Gly Tyr Met Ser Lys Phe           
                425                 430                 435               

ttt agt ggc gat ctg cga gat ttt ggt aca ccc atc acc agc ttg ttt       1639
Phe Ser Gly Asp Leu Arg Asp Phe Gly Thr Pro Ile Thr Ser Leu Phe           
            440                 445                 450                   

aat ttt atc ttt ctt tgt tta tca gtg ctg cta gct gag gag ggg ata       1687
Asn Phe Ile Phe Leu Cys Leu Ser Val Leu Leu Ala Glu Glu Gly Ile           
        455                 460                 465                       

gct cct ctt tct tct gca gga cca ggg aaa gag gag aaa ctc ctg ttt       1735
Ala Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe           
    470                 475                 480                           

gga gaa ggg ttt tct cct ttg ctt cca gtt cag act atc aag gag gaa       1783
Gly Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu           
485                 490                 495                 500           

gaa atc cag cct ggg gag gaa atg cca cac tta gcg aga ccc atc aaa       1831
Glu Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys           
                505                 510                 515               

gtg gag agc cct ccc ttg gaa gag tgg ccc tcc ccg gcc cca tct ttc       1879
Val Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe           
            520                 525                 530                   

aaa gag gaa tca tct cac tcc tgg gag gat tcg tcc caa tct ccc acc       1927
Lys Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr           
        535                 540                 545                       

cca aga ccc aag aag tcc tac agt ggg ctt agg tcc cca acc cgg tgt       1975
Pro Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys           
    550                 555                 560                           

gtc tcg gaa atg ctt gtg att caa cac agg gag agg agg gag agg agc       2023
Val Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser           
565                 570                 575                 580           

cgg tct cgg agg aaa cag cat cta ctg cct ccc tgt gtg gat gag ccg       2071
Arg Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro           
                585                 590                 595               

gag ctg ctc ttc tca gag ggg ccc agt act tcc cgc tgg gcc gca gag       2119
Glu Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu           
            600                 605                 610                   

ctc ccg ttc cca gca gac tcc tct gac cct gcc tcc cag ctc agc tac       2167
Leu Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr           
        615                 620                 625                       

tcc cag gaa gtg gga gga cct ttt aag aca ccc att aag gaa acg ctg       2215
Ser Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu           
    630                 635                 640                           

ccc atc tcc tcc acc ccg agc aaa tct gtc ctc ccc aga acc cct gaa       2263
Pro Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu           
645                 650                 655                 660           

tcc tgg agg ctc acg ccc cca gcc aaa gta ggg gga ctg gat ttc agc       2311
Ser Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser           
                665                 670                 675               

cca gta caa acc tcc cag ggt gcc tct gac ccc ttg cct gac ccc ctg       2359
Pro Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu           
            680                 685                 690                   

ggg ctg atg gat ctc agc acc act ccc ttg caa agt gct ccc ccc ctt       2407
Gly Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu           
        695                 700                 705                       

gaa tca ccg caa agg ctc ctc agt tca gaa ccc tta gac ctc atc tcc       2455
Glu Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser           
    710                 715                 720                           

gtc ccc ttt ggc aac tct tct ccc tca gat ata gac gtc ccc aag cca       2503
Val Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro           
725                 730                 735                 740           

ggc tcc ccg gag cca cag gtt tct ggc ctt gca gcc aat cgt tct ctg       2551
Gly Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu           
                745                 750                 755               

aca gaa ggc ctg gtc ctg gac aca atg aat gac agc ctc agc aag atc       2599
Thr Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile           
            760                 765                 770                   

ctg ctg gac atc agc ttt cct ggc ctg gac gag gac cca ctg ggc cct       2647
Leu Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro           
        775                 780                 785                       

gac aac atc aac tgg tcc cag ttt att cct gag cta cag tag               2689
Asp Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln                       
    790                 795                 800                           

agccctgccc ttgcccctgt gctcaagctg tccaccatcc cgggcactcc aaggctcagt     2749

gcaccccaag cctctgagtg aggacagcag gcagggactg ttctgctcct catagctccc     2809

tgctgcctga ttatgcaaaa gtagcagtca caccctagcc actgctggga ccttgtgttc     2869

cccaagagta tctgattcct ctgctgtccc tgccaggagc tgaagggtgg gaacaacaaa     2929

ggcaatggtg aaaagagatt aggaaccccc cagcctgttt ccattctctg cccagcagtc     2989

tcttaccttc cctgatcttt gcagggtggt ccgtgtaaat agtataaatt ctccaaatta     3049

tcctctaatt ataaatgtaa gcttatttcc ttagatcatt atccagagac tgccagaagg     3109

tgggtaggat gacctggggt ttcaattgac ttctgttcct tgcttttagt tttgatagaa     3169

gggaagacct gcagtgcacg gtttcttcca ggctgaggta cctggatctt gggttcttca     3229

ctgcagggac ccagacaagt ggatctgctt gccagagtcc tttttgcccc tccctgccac     3289

ctccccgtgt ttccaagtca gctttcctgc aagaagaaat cctggttaaa aaagtctttt     3349

gtattgggtc aggagttgaa tttggggtgg gaggatggat gcaactgaag cagagtgtgg     3409

gtgcccagat gtgcgctatt agatgtttct ctgataatgt ccccaatcat accagggaga     3469

ctggcattga cgagaactca ggtggaggct tgagaaggcc gaaagggccc ctgacctgcc     3529

tggcttcctt agcttgcccc tcagctttgc aaagagccac cctaggcccc agctgaccgc     3589

atgggtgtga gccagcttga gaacactaac tactcaataa aagcgaaggt ggacatgaaa     3649

aaaaaaaaaa aaaaaa                                                     3665


<210>  5
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Phe Gly Glu Gln Val Val Phe Gly Tyr 
            420                 425                 430         


Met Ser Lys Phe Phe Ser Gly Asp Leu Arg Asp Phe Gly Thr Pro Ile 
        435                 440                 445             


Thr Ser Leu Phe Asn Phe Ile Phe Leu Cys Leu Ser Val Leu Leu Ala 
    450                 455                 460                 


Glu Glu Gly Ile Ala Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu 
465                 470                 475                 480 


Lys Leu Leu Phe Gly Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr 
                485                 490                 495     


Ile Lys Glu Glu Glu Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala 
            500                 505                 510         


Arg Pro Ile Lys Val Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro 
        515                 520                 525             


Ala Pro Ser Phe Lys Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser 
    530                 535                 540                 


Gln Ser Pro Thr Pro Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser 
545                 550                 555                 560 


Pro Thr Arg Cys Val Ser Glu Met Leu Val Ile Gln His Arg Glu Arg 
                565                 570                 575     


Arg Glu Arg Ser Arg Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys 
            580                 585                 590         


Val Asp Glu Pro Glu Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg 
        595                 600                 605             


Trp Ala Ala Glu Leu Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser 
    610                 615                 620                 


Gln Leu Ser Tyr Ser Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile 
625                 630                 635                 640 


Lys Glu Thr Leu Pro Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro 
                645                 650                 655     


Arg Thr Pro Glu Ser Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly 
            660                 665                 670         


Leu Asp Phe Ser Pro Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu 
        675                 680                 685             


Pro Asp Pro Leu Gly Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser 
    690                 695                 700                 


Ala Pro Pro Leu Glu Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu 
705                 710                 715                 720 


Asp Leu Ile Ser Val Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp 
                725                 730                 735     


Val Pro Lys Pro Gly Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala 
            740                 745                 750         


Asn Arg Ser Leu Thr Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser 
        755                 760                 765             


Leu Ser Lys Ile Leu Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp 
    770                 775                 780                 


Pro Leu Gly Pro Asp Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu 
785                 790                 795                 800 


Gln 
    


<210>  6
<211>  3506
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (284)..(2530)

<400>  6
tttcaaacag cggaacaaac tgaaagctcc ggtgccagac cccacccccg gccccggccc       60

gggaccccct cccctcccgg gatcccccgg ggttcccacc ccgcccgcac cgccggggac      120

ccggccggtc cggcgcgagc ccccgtccgg ggccctggct cggcccccag gttggaggag      180

cccggagccc gccttcggag ctacggccta acggcggcgg cgactgcagt ctggagggtc      240

cacacttgtg attctcaatg gagagtgaaa acgcagattc ata atg aaa act agc        295
                                                Met Lys Thr Ser           
                                                1                         

ccc cgt cgg cca ctg att ctc aaa aga cgg agg ctg ccc ctt cct gtt        343
Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu Pro Leu Pro Val           
5                   10                  15                  20            

caa aat gcc cca agt gaa aca tca gag gag gaa cct aag aga tcc cct        391
Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro Lys Arg Ser Pro           
                25                  30                  35                

gcc caa cag gag tct aat caa gca gag gcc tcc aag gaa gtg gca gag        439
Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys Glu Val Ala Glu           
            40                  45                  50                    

tcc aac tct tgc aag ttt cca gct ggg atc aag att att aac cac ccc        487
Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile Ile Asn His Pro           
        55                  60                  65                        

acc atg ccc aac acg caa gta gtg gcc atc ccc aac aat gct aat att        535
Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn Asn Ala Asn Ile           
    70                  75                  80                            

cac agc atc atc aca gca ctg act gcc aag gga aaa gag agt ggc agt        583
His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys Glu Ser Gly Ser           
85                  90                  95                  100           

agt ggg ccc aac aaa ttc atc ctc atc agc tgt ggg gga gcc cca act        631
Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly Gly Ala Pro Thr           
                105                 110                 115               

cag cct cca gga ctc cgg cct caa acc caa acc agc tat gat gcc aaa        679
Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser Tyr Asp Ala Lys           
            120                 125                 130                   

agg aca gaa gtg acc ctg gag acc ttg gga cca aaa cct gca gct agg        727
Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys Pro Ala Ala Arg           
        135                 140                 145                       

gat gtg aat ctt cct aga cca cct gga gcc ctt tgc gag cag aaa cgg        775
Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys Glu Gln Lys Arg           
    150                 155                 160                           

gag acc tgt gca gat ggt gag gca gca ggc tgc act atc aac aat agc        823
Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr Ile Asn Asn Ser           
165                 170                 175                 180           

cta tcc aac atc cag tgg ctt cga aag atg agt tct gat gga ctg ggc        871
Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser Asp Gly Leu Gly           
                185                 190                 195               

tcc cgc agc atc aag caa gag atg gag gaa aag gag aat tgt cac ctg        919
Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu Asn Cys His Leu           
            200                 205                 210                   

gag cag cga cag gtt aag gtt gag gag cct tcg aga cca tca gcg tcc        967
Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg Pro Ser Ala Ser           
        215                 220                 225                       

tgg cag aac tct gtg tct gag cgg cca ccc tac tct tac atg gcc atg       1015
Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser Tyr Met Ala Met           
    230                 235                 240                           

ata caa ttc gcc atc aac agc act gag agg aag cgc atg act ttg aaa       1063
Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg Met Thr Leu Lys           
245                 250                 255                 260           

gac atc tat acg tgg att gag gac cac ttt ccc tac ttt aag cac att       1111
Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr Phe Lys His Ile           
                265                 270                 275               

gcc aag cca ggc tgg aag aac tcc atc cgc cac aac ctt tcc ctg cac       1159
Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His           
            280                 285                 290                   

gac atg ttt gtc cgg gag acg tct gcc aat ggc aag gtc tcc ttc tgg       1207
Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys Val Ser Phe Trp           
        295                 300                 305                       

acc att cac ccc agt gcc aac cgc tac ttg aca ttg gac cag gtg ttt       1255
Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu Asp Gln Val Phe           
    310                 315                 320                           

aag cag cag aaa cga ccg aat cca gag ctc cgc cgg aac atg acc atc       1303
Lys Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn Met Thr Ile           
325                 330                 335                 340           

aaa acc gaa ctc ccc ctg ggc gca cgg cgg aag atg aag cca ctg cta       1351
Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys Pro Leu Leu           
                345                 350                 355               

cca cgg gtc agc tca tac ctg gta cct atc cag ttc ccg gtg aac cag       1399
Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro Val Asn Gln           
            360                 365                 370                   

tca ctg gtg ttg cag ccc tcg gtg aag gtg cca ttg ccc ctg gcg gct       1447
Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro Leu Ala Ala           
        375                 380                 385                       

tcc ctc atg agc tca gag ctt gcc cgc cat agc aag cga gtc cgc att       1495
Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg Val Arg Ile           
    390                 395                 400                           

gcc ccc aag gtg ctg cta gct gag gag ggg ata gct cct ctt tct tct       1543
Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro Leu Ser Ser           
405                 410                 415                 420           

gca gga cca ggg aaa gag gag aaa ctc ctg ttt gga gaa ggg ttt tct       1591
Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu Gly Phe Ser           
                425                 430                 435               

cct ttg ctt cca gtt cag act atc aag gag gaa gaa atc cag cct ggg       1639
Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile Gln Pro Gly           
            440                 445                 450                   

gag gaa atg cca cac tta gcg aga ccc atc aaa gtg gag agc cct ccc       1687
Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu Ser Pro Pro           
        455                 460                 465                       

ttg gaa gag tgg ccc tcc ccg gcc cca tct ttc aaa gag gaa tca tct       1735
Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu Glu Ser Ser           
    470                 475                 480                           

cac tcc tgg gag gat tcg tcc caa tct ccc acc cca aga ccc aag aag       1783
His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg Pro Lys Lys           
485                 490                 495                 500           

tcc tac agt ggg ctt agg tcc cca acc cgg tgt gtc tcg gaa atg ctt       1831
Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser Glu Met Leu           
                505                 510                 515               

gtg att caa cac agg gag agg agg gag agg agc cgg tct cgg agg aaa       1879
Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser Arg Arg Lys           
            520                 525                 530                   

cag cat cta ctg cct ccc tgt gtg gat gag ccg gag ctg ctc ttc tca       1927
Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu Leu Phe Ser           
        535                 540                 545                       

gag ggg ccc agt act tcc cgc tgg gcc gca gag ctc ccg ttc cca gca       1975
Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro Phe Pro Ala           
    550                 555                 560                           

gac tcc tct gac cct gcc tcc cag ctc agc tac tcc cag gaa gtg gga       2023
Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln Glu Val Gly           
565                 570                 575                 580           

gga cct ttt aag aca ccc att aag gaa acg ctg ccc atc tcc tcc acc       2071
Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile Ser Ser Thr           
                585                 590                 595               

ccg agc aaa tct gtc ctc ccc aga acc cct gaa tcc tgg agg ctc acg       2119
Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp Arg Leu Thr           
            600                 605                 610                   

ccc cca gcc aaa gta ggg gga ctg gat ttc agc cca gta caa acc tcc       2167
Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val Gln Thr Ser           
        615                 620                 625                       

cag ggt gcc tct gac ccc ttg cct gac ccc ctg ggg ctg atg gat ctc       2215
Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu Met Asp Leu           
    630                 635                 640                           

agc acc act ccc ttg caa agt gct ccc ccc ctt gaa tca ccg caa agg       2263
Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser Pro Gln Arg           
645                 650                 655                 660           

ctc ctc agt tca gaa ccc tta gac ctc atc tcc gtc ccc ttt ggc aac       2311
Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro Phe Gly Asn           
                665                 670                 675               

tct tct ccc tca gat ata gac gtc ccc aag cca ggc tcc ccg gag cca       2359
Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser Pro Glu Pro           
            680                 685                 690                   

cag gtt tct ggc ctt gca gcc aat cgt tct ctg aca gaa ggc ctg gtc       2407
Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu Gly Leu Val           
        695                 700                 705                       

ctg gac aca atg aat gac agc ctc agc aag atc ctg ctg gac atc agc       2455
Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu Asp Ile Ser           
    710                 715                 720                           

ttt cct ggc ctg gac gag gac cca ctg ggc cct gac aac atc aac tgg       2503
Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn Ile Asn Trp           
725                 730                 735                 740           

tcc cag ttt att cct gag cta cag tag agccctgccc ttgcccctgt             2550
Ser Gln Phe Ile Pro Glu Leu Gln                                           
                745                                                       

gctcaagctg tccaccatcc cgggcactcc aaggctcagt gcaccccaag cctctgagtg     2610

aggacagcag gcagggactg ttctgctcct catagctccc tgctgcctga ttatgcaaaa     2670

gtagcagtca caccctagcc actgctggga ccttgtgttc cccaagagta tctgattcct     2730

ctgctgtccc tgccaggagc tgaagggtgg gaacaacaaa ggcaatggtg aaaagagatt     2790

aggaaccccc cagcctgttt ccattctctg cccagcagtc tcttaccttc cctgatcttt     2850

gcagggtggt ccgtgtaaat agtataaatt ctccaaatta tcctctaatt ataaatgtaa     2910

gcttatttcc ttagatcatt atccagagac tgccagaagg tgggtaggat gacctggggt     2970

ttcaattgac ttctgttcct tgcttttagt tttgatagaa gggaagacct gcagtgcacg     3030

gtttcttcca ggctgaggta cctggatctt gggttcttca ctgcagggac ccagacaagt     3090

ggatctgctt gccagagtcc tttttgcccc tccctgccac ctccccgtgt ttccaagtca     3150

gctttcctgc aagaagaaat cctggttaaa aaagtctttt gtattgggtc aggagttgaa     3210

tttggggtgg gaggatggat gcaactgaag cagagtgtgg gtgcccagat gtgcgctatt     3270

agatgtttct ctgataatgt ccccaatcat accagggaga ctggcattga cgagaactca     3330

ggtggaggct tgagaaggcc gaaagggccc ctgacctgcc tggcttcctt agcttgcccc     3390

tcagctttgc aaagagccac cctaggcccc agctgaccgc atgggtgtga gccagcttga     3450

gaacactaac tactcaataa aagcgaaggt ggacatgaaa aaaaaaaaaa aaaaaa         3506


<210>  7
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg 
                325                 330                 335     


Asn Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met 
            340                 345                 350         


Lys Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe 
        355                 360                 365             


Pro Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu 
    370                 375                 380                 


Pro Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys 
385                 390                 395                 400 


Arg Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala 
                405                 410                 415     


Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly 
            420                 425                 430         


Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu 
        435                 440                 445             


Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val 
    450                 455                 460                 


Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys 
465                 470                 475                 480 


Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro 
                485                 490                 495     


Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val 
            500                 505                 510         


Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg 
        515                 520                 525             


Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu 
    530                 535                 540                 


Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu 
545                 550                 555                 560 


Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser 
                565                 570                 575     


Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro 
            580                 585                 590         


Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser 
        595                 600                 605             


Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro 
    610                 615                 620                 


Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly 
625                 630                 635                 640 


Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu 
                645                 650                 655     


Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val 
            660                 665                 670         


Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly 
        675                 680                 685             


Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr 
    690                 695                 700                 


Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu 
705                 710                 715                 720 


Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp 
                725                 730                 735     


Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
            740                 745             


<210>  8
<211>  3551
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (284)..(2575)

<400>  8
tttcaaacag cggaacaaac tgaaagctcc ggtgccagac cccacccccg gccccggccc       60

gggaccccct cccctcccgg gatcccccgg ggttcccacc ccgcccgcac cgccggggac      120

ccggccggtc cggcgcgagc ccccgtccgg ggccctggct cggcccccag gttggaggag      180

cccggagccc gccttcggag ctacggccta acggcggcgg cgactgcagt ctggagggtc      240

cacacttgtg attctcaatg gagagtgaaa acgcagattc ata atg aaa act agc        295
                                                Met Lys Thr Ser           
                                                1                         

ccc cgt cgg cca ctg att ctc aaa aga cgg agg ctg ccc ctt cct gtt        343
Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu Pro Leu Pro Val           
5                   10                  15                  20            

caa aat gcc cca agt gaa aca tca gag gag gaa cct aag aga tcc cct        391
Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro Lys Arg Ser Pro           
                25                  30                  35                

gcc caa cag gag tct aat caa gca gag gcc tcc aag gaa gtg gca gag        439
Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys Glu Val Ala Glu           
            40                  45                  50                    

tcc aac tct tgc aag ttt cca gct ggg atc aag att att aac cac ccc        487
Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile Ile Asn His Pro           
        55                  60                  65                        

acc atg ccc aac acg caa gta gtg gcc atc ccc aac aat gct aat att        535
Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn Asn Ala Asn Ile           
    70                  75                  80                            

cac agc atc atc aca gca ctg act gcc aag gga aaa gag agt ggc agt        583
His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys Glu Ser Gly Ser           
85                  90                  95                  100           

agt ggg ccc aac aaa ttc atc ctc atc agc tgt ggg gga gcc cca act        631
Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly Gly Ala Pro Thr           
                105                 110                 115               

cag cct cca gga ctc cgg cct caa acc caa acc agc tat gat gcc aaa        679
Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser Tyr Asp Ala Lys           
            120                 125                 130                   

agg aca gaa gtg acc ctg gag acc ttg gga cca aaa cct gca gct agg        727
Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys Pro Ala Ala Arg           
        135                 140                 145                       

gat gtg aat ctt cct aga cca cct gga gcc ctt tgc gag cag aaa cgg        775
Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys Glu Gln Lys Arg           
    150                 155                 160                           

gag acc tgt gca gat ggt gag gca gca ggc tgc act atc aac aat agc        823
Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr Ile Asn Asn Ser           
165                 170                 175                 180           

cta tcc aac atc cag tgg ctt cga aag atg agt tct gat gga ctg ggc        871
Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser Asp Gly Leu Gly           
                185                 190                 195               

tcc cgc agc atc aag caa gag atg gag gaa aag gag aat tgt cac ctg        919
Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu Asn Cys His Leu           
            200                 205                 210                   

gag cag cga cag gtt aag gtt gag gag cct tcg aga cca tca gcg tcc        967
Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg Pro Ser Ala Ser           
        215                 220                 225                       

tgg cag aac tct gtg tct gag cgg cca ccc tac tct tac atg gcc atg       1015
Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser Tyr Met Ala Met           
    230                 235                 240                           

ata caa ttc gcc atc aac agc act gag agg aag cgc atg act ttg aaa       1063
Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg Met Thr Leu Lys           
245                 250                 255                 260           

gac atc tat acg tgg att gag gac cac ttt ccc tac ttt aag cac att       1111
Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr Phe Lys His Ile           
                265                 270                 275               

gcc aag cca ggc tgg aag aac tcc atc cgc cac aac ctt tcc ctg cac       1159
Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His           
            280                 285                 290                   

gac atg ttt gtc cgg gag acg tct gcc aat ggc aag gtc tcc ttc tgg       1207
Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys Val Ser Phe Trp           
        295                 300                 305                       

acc att cac ccc agt gcc aac cgc tac ttg aca ttg gac cag gtg ttt       1255
Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu Asp Gln Val Phe           
    310                 315                 320                           

aag cca ctg gac cca ggg tct cca caa ttg ccc gag cac ttg gaa tca       1303
Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu His Leu Glu Ser           
325                 330                 335                 340           

cag cag aaa cga ccg aat cca gag ctc cgc cgg aac atg acc atc aaa       1351
Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn Met Thr Ile Lys           
                345                 350                 355               

acc gaa ctc ccc ctg ggc gca cgg cgg aag atg aag cca ctg cta cca       1399
Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys Pro Leu Leu Pro           
            360                 365                 370                   

cgg gtc agc tca tac ctg gta cct atc cag ttc ccg gtg aac cag tca       1447
Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro Val Asn Gln Ser           
        375                 380                 385                       

ctg gtg ttg cag ccc tcg gtg aag gtg cca ttg ccc ctg gcg gct tcc       1495
Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro Leu Ala Ala Ser           
    390                 395                 400                           

ctc atg agc tca gag ctt gcc cgc cat agc aag cga gtc cgc att gcc       1543
Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg Val Arg Ile Ala           
405                 410                 415                 420           

ccc aag gtg ctg cta gct gag gag ggg ata gct cct ctt tct tct gca       1591
Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro Leu Ser Ser Ala           
                425                 430                 435               

gga cca ggg aaa gag gag aaa ctc ctg ttt gga gaa ggg ttt tct cct       1639
Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu Gly Phe Ser Pro           
            440                 445                 450                   

ttg ctt cca gtt cag act atc aag gag gaa gaa atc cag cct ggg gag       1687
Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile Gln Pro Gly Glu           
        455                 460                 465                       

gaa atg cca cac tta gcg aga ccc atc aaa gtg gag agc cct ccc ttg       1735
Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu Ser Pro Pro Leu           
    470                 475                 480                           

gaa gag tgg ccc tcc ccg gcc cca tct ttc aaa gag gaa tca tct cac       1783
Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu Glu Ser Ser His           
485                 490                 495                 500           

tcc tgg gag gat tcg tcc caa tct ccc acc cca aga ccc aag aag tcc       1831
Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg Pro Lys Lys Ser           
                505                 510                 515               

tac agt ggg ctt agg tcc cca acc cgg tgt gtc tcg gaa atg ctt gtg       1879
Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser Glu Met Leu Val           
            520                 525                 530                   

att caa cac agg gag agg agg gag agg agc cgg tct cgg agg aaa cag       1927
Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser Arg Arg Lys Gln           
        535                 540                 545                       

cat cta ctg cct ccc tgt gtg gat gag ccg gag ctg ctc ttc tca gag       1975
His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu Leu Phe Ser Glu           
    550                 555                 560                           

ggg ccc agt act tcc cgc tgg gcc gca gag ctc ccg ttc cca gca gac       2023
Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro Phe Pro Ala Asp           
565                 570                 575                 580           

tcc tct gac cct gcc tcc cag ctc agc tac tcc cag gaa gtg gga gga       2071
Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln Glu Val Gly Gly           
                585                 590                 595               

cct ttt aag aca ccc att aag gaa acg ctg ccc atc tcc tcc acc ccg       2119
Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile Ser Ser Thr Pro           
            600                 605                 610                   

agc aaa tct gtc ctc ccc aga acc cct gaa tcc tgg agg ctc acg ccc       2167
Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp Arg Leu Thr Pro           
        615                 620                 625                       

cca gcc aaa gta ggg gga ctg gat ttc agc cca gta caa acc tcc cag       2215
Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val Gln Thr Ser Gln           
    630                 635                 640                           

ggt gcc tct gac ccc ttg cct gac ccc ctg ggg ctg atg gat ctc agc       2263
Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu Met Asp Leu Ser           
645                 650                 655                 660           

acc act ccc ttg caa agt gct ccc ccc ctt gaa tca ccg caa agg ctc       2311
Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser Pro Gln Arg Leu           
                665                 670                 675               

ctc agt tca gaa ccc tta gac ctc atc tcc gtc ccc ttt ggc aac tct       2359
Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro Phe Gly Asn Ser           
            680                 685                 690                   

tct ccc tca gat ata gac gtc ccc aag cca ggc tcc ccg gag cca cag       2407
Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser Pro Glu Pro Gln           
        695                 700                 705                       

gtt tct ggc ctt gca gcc aat cgt tct ctg aca gaa ggc ctg gtc ctg       2455
Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu Gly Leu Val Leu           
    710                 715                 720                           

gac aca atg aat gac agc ctc agc aag atc ctg ctg gac atc agc ttt       2503
Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu Asp Ile Ser Phe           
725                 730                 735                 740           

cct ggc ctg gac gag gac cca ctg ggc cct gac aac atc aac tgg tcc       2551
Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn Ile Asn Trp Ser           
                745                 750                 755               

cag ttt att cct gag cta cag tag agccctgccc ttgcccctgt gctcaagctg      2605
Gln Phe Ile Pro Glu Leu Gln                                               
            760                                                           

tccaccatcc cgggcactcc aaggctcagt gcaccccaag cctctgagtg aggacagcag     2665

gcagggactg ttctgctcct catagctccc tgctgcctga ttatgcaaaa gtagcagtca     2725

caccctagcc actgctggga ccttgtgttc cccaagagta tctgattcct ctgctgtccc     2785

tgccaggagc tgaagggtgg gaacaacaaa ggcaatggtg aaaagagatt aggaaccccc     2845

cagcctgttt ccattctctg cccagcagtc tcttaccttc cctgatcttt gcagggtggt     2905

ccgtgtaaat agtataaatt ctccaaatta tcctctaatt ataaatgtaa gcttatttcc     2965

ttagatcatt atccagagac tgccagaagg tgggtaggat gacctggggt ttcaattgac     3025

ttctgttcct tgcttttagt tttgatagaa gggaagacct gcagtgcacg gtttcttcca     3085

ggctgaggta cctggatctt gggttcttca ctgcagggac ccagacaagt ggatctgctt     3145

gccagagtcc tttttgcccc tccctgccac ctccccgtgt ttccaagtca gctttcctgc     3205

aagaagaaat cctggttaaa aaagtctttt gtattgggtc aggagttgaa tttggggtgg     3265

gaggatggat gcaactgaag cagagtgtgg gtgcccagat gtgcgctatt agatgtttct     3325

ctgataatgt ccccaatcat accagggaga ctggcattga cgagaactca ggtggaggct     3385

tgagaaggcc gaaagggccc ctgacctgcc tggcttcctt agcttgcccc tcagctttgc     3445

aaagagccac cctaggcccc agctgaccgc atgggtgtga gccagcttga gaacactaac     3505

tactcaataa aagcgaaggt ggacatgaaa aaaaaaaaaa aaaaaa                    3551


<210>  9
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro 
            420                 425                 430         


Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu 
        435                 440                 445             


Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile 
    450                 455                 460                 


Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu 
465                 470                 475                 480 


Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu 
                485                 490                 495     


Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg 
            500                 505                 510         


Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser 
        515                 520                 525             


Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser 
    530                 535                 540                 


Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu 
545                 550                 555                 560 


Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro 
                565                 570                 575     


Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln 
            580                 585                 590         


Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile 
        595                 600                 605             


Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp 
    610                 615                 620                 


Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val 
625                 630                 635                 640 


Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu 
                645                 650                 655     


Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser 
            660                 665                 670         


Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro 
        675                 680                 685             


Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser 
    690                 695                 700                 


Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu 
705                 710                 715                 720 


Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu 
                725                 730                 735     


Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn 
            740                 745                 750         


Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
        755                 760             


