                               SEQUENCE LISTING

<110> PORTAGE PHARMACEUTICALS LTD.
 
<120> STRUCTURE, MANUFACTURING AND USES OF HUMAN-DERIVED 
      CELL-PERMEABLE PEPTIDES CONJUGATED WITH SPECIFIC 
      BIOLOGICALLY ACTIVE CARGO PEPTIDES

<130> 89352-8002.WO00

<140> PCT/IB14/02029
<141> 2014-06-11

<150> 61/833,819
<151> 2013-06-11

<160> 117   

<170> PatentIn version 3.5

<210> 1
<211> 60
<212> PRT
<213> Homo sapiens

<400> 1
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu 
    50                  55                  60  


<210> 2
<211> 60
<212> PRT
<213> Homo sapiens

<400> 2
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val 
    50                  55                  60  


<210> 3
<211> 60
<212> PRT
<213> Homo sapiens

<400> 3
Gln Lys Arg His Arg Thr Arg Phe Thr Pro Ala Gln Leu Asn Glu Leu 
1               5                   10                  15      


Glu Arg Ser Phe Ala Lys Thr His Tyr Pro Asp Ile Phe Met Arg Glu 
            20                  25                  30          


Glu Leu Ala Leu Arg Ile Gly Leu Thr Glu Ser Arg Val Gln Val Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Ala Lys Trp Lys Lys Arg Lys 
    50                  55                  60  


<210> 4
<211> 60
<212> PRT
<213> Homo sapiens

<400> 4
Lys Lys Lys Pro Arg Thr Ser Phe Thr Arg Leu Gln Ile Cys Glu Leu 
1               5                   10                  15      


Glu Lys Arg Phe His Arg Gln Lys Tyr Leu Ala Ser Ala Glu Arg Ala 
            20                  25                  30          


Ala Leu Ala Lys Ala Leu Lys Met Thr Asp Ala Gln Val Lys Thr Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Thr Lys Trp Arg Arg Gln Thr 
    50                  55                  60  


<210> 5
<211> 60
<212> PRT
<213> Homo sapiens

<400> 5
Arg Lys Lys Pro Arg Thr Ser Phe Ser Arg Val Gln Ile Cys Glu Leu 
1               5                   10                  15      


Glu Lys Arg Phe His Arg Gln Lys Tyr Leu Ala Ser Ala Glu Arg Ala 
            20                  25                  30          


Ala Leu Ala Lys Ser Leu Lys Met Thr Asp Ala Gln Val Lys Thr Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Thr Lys Trp Arg Arg Gln Thr 
    50                  55                  60  


<210> 6
<211> 60
<212> PRT
<213> Homo sapiens

<400> 6
Arg Lys Lys Pro Arg Thr Ser Phe Ser Arg Ser Gln Val Leu Glu Leu 
1               5                   10                  15      


Glu Arg Arg Phe Leu Arg Gln Lys Tyr Leu Ala Ser Ala Glu Arg Ala 
            20                  25                  30          


Ala Leu Ala Lys Ala Leu Arg Met Thr Asp Ala Gln Val Lys Thr Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Thr Lys Trp Arg Arg Gln Thr 
    50                  55                  60  


<210> 7
<211> 60
<212> PRT
<213> Homo sapiens

<400> 7
Arg Lys His Thr Arg Pro Thr Phe Ser Gly Gln Gln Ile Phe Ala Leu 
1               5                   10                  15      


Glu Lys Thr Phe Glu Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala 
            20                  25                  30          


Arg Leu Ala Tyr Ser Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Thr Lys Trp Arg Lys Lys His 
    50                  55                  60  


<210> 8
<211> 60
<212> PRT
<213> Homo sapiens

<400> 8
Lys Lys His Ser Arg Pro Thr Phe Ser Gly Gln Gln Ile Phe Ala Leu 
1               5                   10                  15      


Glu Lys Thr Phe Glu Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala 
            20                  25                  30          


Arg Leu Ala Tyr Ser Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Thr Lys Trp Arg Lys Arg His 
    50                  55                  60  


<210> 9
<211> 60
<212> PRT
<213> Homo sapiens

<400> 9
Lys Lys His Thr Arg Pro Thr Phe Thr Gly His Gln Ile Phe Ala Leu 
1               5                   10                  15      


Glu Lys Thr Phe Glu Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala 
            20                  25                  30          


Arg Leu Ala Tyr Ser Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Thr Lys Trp Arg Lys Lys Ser 
    50                  55                  60  


<210> 10
<211> 60
<212> PRT
<213> Homo sapiens

<400> 10
Lys Lys Arg Ser Arg Ala Ala Phe Ser His Ala Gln Val Phe Glu Leu 
1               5                   10                  15      


Glu Arg Arg Phe Asn His Gln Arg Tyr Leu Ser Gly Pro Glu Arg Ala 
            20                  25                  30          


Asp Leu Ala Ala Ser Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Tyr Lys Thr Lys Arg Arg Gln 
    50                  55                  60  


<210> 11
<211> 60
<212> PRT
<213> Homo sapiens

<400> 11
Pro Arg Lys Ala Arg Thr Ala Phe Thr Asp His Gln Leu Ala Gln Leu 
1               5                   10                  15      


Glu Arg Ser Phe Glu Arg Gln Lys Tyr Leu Ser Val Gln Asp Arg Met 
            20                  25                  30          


Glu Leu Ala Ala Ser Leu Asn Leu Thr Asp Thr Gln Val Lys Thr Trp 
        35                  40                  45              


Tyr Gln Asn Arg Arg Thr Lys Trp Lys Arg Gln Thr 
    50                  55                  60  


<210> 12
<211> 60
<212> PRT
<213> Homo sapiens

<400> 12
Pro Arg Lys Ala Arg Thr Ala Phe Ser Asp His Gln Leu Asn Gln Leu 
1               5                   10                  15      


Glu Arg Ser Phe Glu Arg Gln Lys Tyr Leu Ser Val Gln Asp Arg Met 
            20                  25                  30          


Asp Leu Ala Ala Ala Leu Asn Leu Thr Asp Thr Gln Val Lys Thr Trp 
        35                  40                  45              


Tyr Gln Asn Arg Arg Thr Lys Trp Lys Arg Gln Thr 
    50                  55                  60  


<210> 13
<211> 60
<212> PRT
<213> Homo sapiens

<400> 13
Gly Arg Arg Ser Arg Thr Val Phe Thr Glu Leu Gln Leu Met Gly Leu 
1               5                   10                  15      


Glu Lys Arg Phe Glu Lys Gln Lys Tyr Leu Ser Thr Pro Asp Arg Ile 
            20                  25                  30          


Asp Leu Ala Glu Ser Leu Gly Leu Ser Gln Leu Gln Val Lys Thr Trp 
        35                  40                  45              


Tyr Gln Asn Arg Arg Met Lys Trp Lys Lys Ile Val 
    50                  55                  60  


<210> 14
<211> 60
<212> PRT
<213> Homo sapiens

<400> 14
Pro Arg Arg Ser Arg Thr Ile Phe Thr Glu Leu Gln Leu Met Gly Leu 
1               5                   10                  15      


Glu Lys Lys Phe Gln Lys Gln Lys Tyr Leu Ser Thr Pro Asp Arg Leu 
            20                  25                  30          


Asp Leu Ala Gln Ser Leu Gly Leu Thr Gln Leu Gln Val Lys Thr Trp 
        35                  40                  45              


Tyr Gln Asn Arg Arg Met Lys Trp Lys Lys Met Val 
    50                  55                  60  


<210> 15
<211> 60
<212> PRT
<213> Homo sapiens

<400> 15
Arg Arg Lys Ala Arg Thr Val Phe Ser Asp Ser Gln Leu Ser Gly Leu 
1               5                   10                  15      


Glu Lys Arg Phe Glu Ile Gln Arg Tyr Leu Ser Thr Pro Glu Arg Val 
            20                  25                  30          


Glu Leu Ala Thr Ala Leu Ser Leu Ser Glu Thr Gln Val Lys Thr Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys His Lys Lys Gln Leu 
    50                  55                  60  


<210> 16
<211> 60
<212> PRT
<213> Homo sapiens

<400> 16
Val Arg Lys Pro Arg Thr Ile Tyr Ser Ser Phe Gln Leu Ala Ala Leu 
1               5                   10                  15      


Gln Arg Arg Phe Gln Lys Thr Gln Tyr Leu Ala Leu Pro Glu Arg Ala 
            20                  25                  30          


Glu Leu Ala Ala Ser Leu Gly Leu Thr Gln Thr Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Ser Lys Phe Lys Lys Met Trp 
    50                  55                  60  


<210> 17
<211> 60
<212> PRT
<213> Homo sapiens

<400> 17
Val Arg Lys Pro Arg Thr Ile Tyr Ser Ser Tyr Gln Leu Ala Ala Leu 
1               5                   10                  15      


Gln Arg Arg Phe Gln Lys Ala Gln Tyr Leu Ala Leu Pro Glu Arg Ala 
            20                  25                  30          


Glu Leu Ala Ala Gln Leu Gly Leu Thr Gln Thr Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Ser Lys Phe Lys Lys Leu Tyr 
    50                  55                  60  


<210> 18
<211> 60
<212> PRT
<213> Homo sapiens

<400> 18
Gly Met Leu Arg Arg Ala Val Phe Ser Asp Val Gln Arg Lys Ala Leu 
1               5                   10                  15      


Glu Lys Met Phe Gln Lys Gln Lys Tyr Ile Ser Lys Pro Asp Arg Lys 
            20                  25                  30          


Lys Leu Ala Ala Lys Leu Gly Leu Lys Asp Ser Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Arg Asn Ser Lys 
    50                  55                  60  


<210> 19
<211> 60
<212> PRT
<213> Homo sapiens

<400> 19
Gly Ile Leu Arg Arg Ala Val Phe Ser Glu Asp Gln Arg Lys Ala Leu 
1               5                   10                  15      


Glu Lys Met Phe Gln Lys Gln Lys Tyr Ile Ser Lys Thr Asp Arg Lys 
            20                  25                  30          


Lys Leu Ala Ile Asn Leu Gly Leu Lys Glu Ser Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Arg Asn Ser Lys 
    50                  55                  60  


<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Thr Ala Leu Asp Trp Ser Trp Leu Gln Thr Glu 
1               5                   10      


<210> 21
<211> 71
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Thr Ala Leu Asp 
    50                  55                  60                  


Trp Ser Trp Leu Gln Thr Glu 
65                  70      


<210> 22
<211> 71
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Thr Ala Leu Asp 
    50                  55                  60                  


Trp Ser Trp Leu Gln Thr Glu 
65                  70      


<210> 23
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Val Ile Leu Arg Trp Arg Tyr His Ala Leu Arg Gly Glu Leu Tyr Arg 
1               5                   10                  15      


Pro Ala Trp Glu Pro Gln Asp Tyr Glu Met Val Glu Leu Phe Leu Arg 
            20                  25                  30          


Arg Leu Arg Leu Trp Met Gly Leu Ser Lys Val Lys Glu Phe Arg His 
        35                  40                  45              


Lys Val Arg Phe Glu Gly Met Glu Pro Leu Pro Ser Arg Ser Ser Arg 
    50                  55                  60                  


Gly Ser Lys Val Ser Pro Asp Val Pro Pro Pro Ser Ala Gly Ser Asp 
65                  70                  75                  80  


Ala Ser His Pro Ser Thr Ser Ser Ser Gln Leu Asp Gly Leu Ser Val 
                85                  90                  95      


Ser Leu Gly Arg Leu Gly Thr Arg Cys Glu Pro Glu Pro Ser Arg Leu 
            100                 105                 110         


Gln Ala Val Phe Glu Ala Leu Leu Thr Gln Phe Asp Arg Leu Asn Gln 
        115                 120                 125             


Ala Thr Glu Asp Val Tyr Gln Leu Glu Gln Gln Leu His Ser Leu Gln 
    130                 135                 140                 


Gly Arg Arg Ser Ser Arg Ala Pro Ala Gly Ser Ser Arg Gly Pro Ser 
145                 150                 155                 160 


Pro Gly Leu Arg Pro Ala Leu Pro Ser Arg Leu Ala Arg Ala Ser Arg 
                165                 170                 175     


Gly Val Asp Leu Ala Thr Gly Pro Ser Arg Thr Pro Leu Arg Ala Lys 
            180                 185                 190         


Asn Lys Val His Pro Ser Ser Thr 
        195                 200 


<210> 24
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Val Ile Leu 
    50                  55                  60                  


Arg Trp Arg Tyr His Ala Leu Arg Gly Glu Leu Tyr Arg Pro Ala Trp 
65                  70                  75                  80  


Glu Pro Gln Asp Tyr Glu Met Val Glu Leu Phe Leu Arg Arg Leu Arg 
                85                  90                  95      


Leu Trp Met Gly Leu Ser Lys Val Lys Glu Phe Arg His Lys Val Arg 
            100                 105                 110         


Phe Glu Gly Met Glu Pro Leu Pro Ser Arg Ser Ser Arg Gly Ser Lys 
        115                 120                 125             


Val Ser Pro Asp Val Pro Pro Pro Ser Ala Gly Ser Asp Ala Ser His 
    130                 135                 140                 


Pro Ser Thr Ser Ser Ser Gln Leu Asp Gly Leu Ser Val Ser Leu Gly 
145                 150                 155                 160 


Arg Leu Gly Thr Arg Cys Glu Pro Glu Pro Ser Arg Leu Gln Ala Val 
                165                 170                 175     


Phe Glu Ala Leu Leu Thr Gln Phe Asp Arg Leu Asn Gln Ala Thr Glu 
            180                 185                 190         


Asp Val Tyr Gln Leu Glu Gln Gln Leu His Ser Leu Gln Gly Arg Arg 
        195                 200                 205             


Ser Ser Arg Ala Pro Ala Gly Ser Ser Arg Gly Pro Ser Pro Gly Leu 
    210                 215                 220                 


Arg Pro Ala Leu Pro Ser Arg Leu Ala Arg Ala Ser Arg Gly Val Asp 
225                 230                 235                 240 


Leu Ala Thr Gly Pro Ser Arg Thr Pro Leu Arg Ala Lys Asn Lys Val 
                245                 250                 255     


His Pro Ser Ser Thr 
            260     


<210> 25
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Val Ile Leu 
    50                  55                  60                  


Arg Trp Arg Tyr His Ala Leu Arg Gly Glu Leu Tyr Arg Pro Ala Trp 
65                  70                  75                  80  


Glu Pro Gln Asp Tyr Glu Met Val Glu Leu Phe Leu Arg Arg Leu Arg 
                85                  90                  95      


Leu Trp Met Gly Leu Ser Lys Val Lys Glu Phe Arg His Lys Val Arg 
            100                 105                 110         


Phe Glu Gly Met Glu Pro Leu Pro Ser Arg Ser Ser Arg Gly Ser Lys 
        115                 120                 125             


Val Ser Pro Asp Val Pro Pro Pro Ser Ala Gly Ser Asp Ala Ser His 
    130                 135                 140                 


Pro Ser Thr Ser Ser Ser Gln Leu Asp Gly Leu Ser Val Ser Leu Gly 
145                 150                 155                 160 


Arg Leu Gly Thr Arg Cys Glu Pro Glu Pro Ser Arg Leu Gln Ala Val 
                165                 170                 175     


Phe Glu Ala Leu Leu Thr Gln Phe Asp Arg Leu Asn Gln Ala Thr Glu 
            180                 185                 190         


Asp Val Tyr Gln Leu Glu Gln Gln Leu His Ser Leu Gln Gly Arg Arg 
        195                 200                 205             


Ser Ser Arg Ala Pro Ala Gly Ser Ser Arg Gly Pro Ser Pro Gly Leu 
    210                 215                 220                 


Arg Pro Ala Leu Pro Ser Arg Leu Ala Arg Ala Ser Arg Gly Val Asp 
225                 230                 235                 240 


Leu Ala Thr Gly Pro Ser Arg Thr Pro Leu Arg Ala Lys Asn Lys Val 
                245                 250                 255     


His Pro Ser Ser Thr 
            260     


<210> 26
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: p21 peptide

<400> 26
Ile Arg Arg Ile Arg Leu Trp Met Gly Leu Ser Lys Val Lys Glu Phe 
1               5                   10                  15      


Arg His Lys Val Arg 
            20      


<210> 27
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Ile Arg Arg 
    50                  55                  60                  


Ile Arg Leu Trp Met Gly Leu Ser Lys Val Lys Glu Phe Arg His Lys 
65                  70                  75                  80  


Val Arg 
        


<210> 28
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Ile Arg Arg 
    50                  55                  60                  


Ile Arg Leu Trp Met Gly Leu Ser Lys Val Lys Glu Phe Arg His Lys 
65                  70                  75                  80  


Val Arg 
        


<210> 29
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Cys Arg Ala Val Lys Tyr 
1               5       


<210> 30
<211> 497
<212> PRT
<213> Homo sapiens

<400> 30
Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210> 31
<211> 558
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Ala Arg Pro 
    50                  55                  60                  


Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn 
65                  70                  75                  80  


Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly 
                85                  90                  95      


Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu 
            100                 105                 110         


Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu 
        115                 120                 125             


Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly 
    130                 135                 140                 


Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro 
145                 150                 155                 160 


Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly 
                165                 170                 175     


Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg 
            180                 185                 190         


Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe 
        195                 200                 205             


Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg 
    210                 215                 220                 


Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp 
225                 230                 235                 240 


Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly 
                245                 250                 255     


Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg 
            260                 265                 270         


Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe 
        275                 280                 285             


Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly 
    290                 295                 300                 


Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe 
305                 310                 315                 320 


Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr His His Asn 
                325                 330                 335     


Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp 
            340                 345                 350         


Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly 
        355                 360                 365             


Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr 
    370                 375                 380                 


Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser 
385                 390                 395                 400 


Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly 
                405                 410                 415     


Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu 
            420                 425                 430         


Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro 
        435                 440                 445             


Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile 
    450                 455                 460                 


Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His 
465                 470                 475                 480 


Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly 
                485                 490                 495     


Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala Leu Met His 
            500                 505                 510         


Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser Ser Lys Asp 
        515                 520                 525             


Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile 
    530                 535                 540                 


Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg Gln 
545                 550                 555             


<210> 32
<211> 558
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Ala Arg Pro 
    50                  55                  60                  


Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn 
65                  70                  75                  80  


Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly 
                85                  90                  95      


Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu 
            100                 105                 110         


Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu 
        115                 120                 125             


Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly 
    130                 135                 140                 


Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro 
145                 150                 155                 160 


Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly 
                165                 170                 175     


Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg 
            180                 185                 190         


Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe 
        195                 200                 205             


Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg 
    210                 215                 220                 


Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp 
225                 230                 235                 240 


Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly 
                245                 250                 255     


Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg 
            260                 265                 270         


Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe 
        275                 280                 285             


Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly 
    290                 295                 300                 


Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe 
305                 310                 315                 320 


Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr His His Asn 
                325                 330                 335     


Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp 
            340                 345                 350         


Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly 
        355                 360                 365             


Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr 
    370                 375                 380                 


Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser 
385                 390                 395                 400 


Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly 
                405                 410                 415     


Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu 
            420                 425                 430         


Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro 
        435                 440                 445             


Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile 
    450                 455                 460                 


Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His 
465                 470                 475                 480 


Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly 
                485                 490                 495     


Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala Leu Met His 
            500                 505                 510         


Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser Ser Lys Asp 
        515                 520                 525             


Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile 
    530                 535                 540                 


Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg Gln 
545                 550                 555             


<210> 33
<211> 1052
<212> PRT
<213> Homo sapiens

<400> 33
Ala Val Phe Thr Val Gly Val Leu Gly Pro Trp Ala Cys Asp Pro Ile 
1               5                   10                  15      


Phe Ser Arg Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala Ala Ala Arg 
            20                  25                  30          


Leu Asn Arg Asp Pro Gly Leu Ala Gly Gly Pro Arg Phe Glu Val Ala 
        35                  40                  45              


Leu Leu Pro Glu Pro Cys Arg Thr Pro Gly Ser Leu Gly Ala Val Ser 
    50                  55                  60                  


Ser Ala Leu Ala Arg Val Ser Gly Leu Val Gly Pro Val Asn Pro Ala 
65                  70                  75                  80  


Ala Cys Arg Pro Ala Glu Leu Leu Ala Glu Glu Ala Gly Ile Ala Leu 
                85                  90                  95      


Val Pro Trp Gly Cys Pro Trp Thr Gln Ala Glu Gly Thr Thr Ala Pro 
            100                 105                 110         


Ala Val Thr Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu Arg Ala Phe 
        115                 120                 125             


Gly Trp Ala Arg Val Ala Leu Val Thr Ala Pro Gln Asp Leu Trp Val 
    130                 135                 140                 


Glu Ala Gly Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg Gly Leu Pro 
145                 150                 155                 160 


Val Ala Ser Val Thr Ser Met Glu Pro Leu Asp Leu Ser Gly Ala Arg 
                165                 170                 175     


Glu Ala Leu Arg Lys Val Arg Asp Gly Pro Arg Val Thr Ala Val Ile 
            180                 185                 190         


Met Val Met His Ser Val Leu Leu Gly Gly Glu Glu Gln Arg Tyr Leu 
        195                 200                 205             


Leu Glu Ala Ala Glu Glu Leu Gly Leu Thr Asp Gly Ser Leu Val Phe 
    210                 215                 220                 


Leu Pro Phe Asp Thr Ile His Tyr Ala Leu Ser Pro Gly Pro Glu Ala 
225                 230                 235                 240 


Leu Ala Ala Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala His Asp Ala 
                245                 250                 255     


Val Leu Thr Leu Thr Arg His Cys Pro Ser Glu Gly Ser Val Leu Asp 
            260                 265                 270         


Ser Leu Arg Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser Asp Leu Asn 
        275                 280                 285             


Leu Gln Gln Val Ser Pro Leu Phe Gly Thr Ile Tyr Asp Ala Val Phe 
    290                 295                 300                 


Leu Leu Ala Arg Gly Val Ala Glu Ala Arg Ala Ala Ala Gly Gly Arg 
305                 310                 315                 320 


Trp Val Ser Gly Ala Ala Val Ala Arg His Ile Arg Asp Ala Gln Val 
                325                 330                 335     


Pro Gly Phe Cys Gly Asp Leu Gly Gly Asp Glu Glu Pro Pro Phe Val 
            340                 345                 350         


Leu Leu Asp Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala Thr Tyr Met 
        355                 360                 365             


Leu Asp Pro Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr Arg Met His 
    370                 375                 380                 


Phe Pro Arg Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser Cys Trp Phe 
385                 390                 395                 400 


Asp Pro Asn Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly Leu Val Phe 
                405                 410                 415     


Leu Gly Phe Leu Leu Val Val Gly Met Gly Leu Ala Gly Ala Phe Leu 
            420                 425                 430         


Ala His Tyr Val Arg His Arg Leu Leu His Met Gln Met Val Ser Gly 
        435                 440                 445             


Pro Asn Lys Ile Ile Leu Thr Val Asp Asp Ile Thr Phe Leu His Pro 
    450                 455                 460                 


His Gly Gly Thr Ser Arg Lys Val Ala Gln Gly Ser Arg Ser Ser Leu 
465                 470                 475                 480 


Gly Ala Arg Ser Met Ser Asp Ile Arg Ser Gly Pro Ser Gln His Leu 
                485                 490                 495     


Asp Ser Pro Asn Ile Gly Val Tyr Glu Gly Asp Arg Val Trp Leu Lys 
            500                 505                 510         


Lys Phe Pro Gly Asp Gln His Ile Ala Ile Arg Pro Ala Thr Lys Thr 
        515                 520                 525             


Ala Phe Ser Lys Leu Gln Glu Leu Arg His Glu Asn Val Ala Leu Tyr 
    530                 535                 540                 


Leu Gly Leu Phe Leu Ala Arg Gly Ala Glu Gly Pro Ala Ala Leu Trp 
545                 550                 555                 560 


Glu Gly Asn Leu Ala Val Val Ser Glu His Cys Thr Arg Gly Ser Leu 
                565                 570                 575     


Gln Asp Leu Leu Ala Gln Arg Glu Ile Lys Leu Asp Trp Met Phe Lys 
            580                 585                 590         


Ser Ser Leu Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr Leu His His 
        595                 600                 605             


Arg Gly Val Ala His Gly Arg Leu Lys Ser Arg Asn Cys Ile Val Asp 
    610                 615                 620                 


Gly Arg Phe Val Leu Lys Ile Thr Asp His Gly His Gly Arg Leu Leu 
625                 630                 635                 640 


Glu Ala Gln Lys Val Leu Pro Glu Pro Pro Arg Ala Glu Asp Gln Leu 
                645                 650                 655     


Trp Thr Ala Pro Glu Leu Leu Arg Asp Pro Ala Leu Glu Arg Arg Gly 
            660                 665                 670         


Thr Leu Ala Gly Asp Val Phe Ser Leu Ala Ile Ile Met Gln Glu Val 
        675                 680                 685             


Val Cys Arg Ser Ala Pro Tyr Ala Met Leu Glu Leu Thr Pro Glu Glu 
    690                 695                 700                 


Val Val Gln Arg Val Arg Ser Pro Pro Pro Leu Cys Arg Pro Leu Val 
705                 710                 715                 720 


Ser Met Asp Gln Ala Pro Val Glu Cys Ile Leu Leu Met Lys Gln Cys 
                725                 730                 735     


Trp Ala Glu Gln Pro Glu Leu Arg Pro Ser Met Asp His Thr Phe Asp 
            740                 745                 750         


Leu Phe Lys Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile Ile Asp Ser 
        755                 760                 765             


Met Leu Arg Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu Asp Leu Ile 
    770                 775                 780                 


Arg Glu Arg Thr Glu Glu Leu Glu Leu Glu Lys Gln Lys Thr Asp Arg 
785                 790                 795                 800 


Leu Leu Thr Gln Met Leu Pro Pro Ser Val Ala Glu Ala Leu Lys Thr 
                805                 810                 815     


Gly Thr Pro Val Glu Pro Glu Tyr Phe Glu Gln Val Thr Leu Tyr Phe 
            820                 825                 830         


Ser Asp Ile Val Gly Phe Thr Thr Ile Ser Ala Met Ser Glu Pro Ile 
        835                 840                 845             


Glu Val Val Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe Asp Ala Ile 
    850                 855                 860                 


Ile Gly Ser His Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr 
865                 870                 875                 880 


Met Val Ala Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg His Ala Ala 
                885                 890                 895     


Glu Ile Ala Asn Met Ser Leu Asp Ile Leu Ser Ala Val Gly Thr Phe 
            900                 905                 910         


Arg Met Arg His Met Pro Glu Val Pro Val Arg Ile Arg Ile Gly Leu 
        915                 920                 925             


His Ser Gly Pro Cys Val Ala Gly Val Val Gly Leu Thr Met Pro Arg 
    930                 935                 940                 


Tyr Cys Leu Phe Gly Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser 
945                 950                 955                 960 


Thr Gly Leu Pro Tyr Arg Ile His Val Asn Leu Ser Thr Val Gly Ile 
                965                 970                 975     


Leu Arg Ala Leu Asp Ser Gly Tyr Gln Val Glu Leu Arg Gly Arg Thr 
            980                 985                 990         


Glu Leu Lys Gly Lys Gly Ala Glu  Asp Thr Phe Trp Leu  Val Gly Arg 
        995                 1000                 1005             


Arg Gly  Phe Asn Lys Pro Ile  Pro Lys Pro Pro Asp  Leu Gln Pro 
    1010                 1015                 1020             


Gly Ser  Ser Asn His Gly Ile  Ser Leu Gln Glu Ile  Pro Pro Glu 
    1025                 1030                 1035             


Arg Arg  Arg Lys Leu Glu Lys  Ala Arg Pro Gly Gln  Phe Ser 
    1040                 1045                 1050         


<210> 34
<211> 1113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Ala Val Phe 
    50                  55                  60                  


Thr Val Gly Val Leu Gly Pro Trp Ala Cys Asp Pro Ile Phe Ser Arg 
65                  70                  75                  80  


Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala Ala Ala Arg Leu Asn Arg 
                85                  90                  95      


Asp Pro Gly Leu Ala Gly Gly Pro Arg Phe Glu Val Ala Leu Leu Pro 
            100                 105                 110         


Glu Pro Cys Arg Thr Pro Gly Ser Leu Gly Ala Val Ser Ser Ala Leu 
        115                 120                 125             


Ala Arg Val Ser Gly Leu Val Gly Pro Val Asn Pro Ala Ala Cys Arg 
    130                 135                 140                 


Pro Ala Glu Leu Leu Ala Glu Glu Ala Gly Ile Ala Leu Val Pro Trp 
145                 150                 155                 160 


Gly Cys Pro Trp Thr Gln Ala Glu Gly Thr Thr Ala Pro Ala Val Thr 
                165                 170                 175     


Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu Arg Ala Phe Gly Trp Ala 
            180                 185                 190         


Arg Val Ala Leu Val Thr Ala Pro Gln Asp Leu Trp Val Glu Ala Gly 
        195                 200                 205             


Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg Gly Leu Pro Val Ala Ser 
    210                 215                 220                 


Val Thr Ser Met Glu Pro Leu Asp Leu Ser Gly Ala Arg Glu Ala Leu 
225                 230                 235                 240 


Arg Lys Val Arg Asp Gly Pro Arg Val Thr Ala Val Ile Met Val Met 
                245                 250                 255     


His Ser Val Leu Leu Gly Gly Glu Glu Gln Arg Tyr Leu Leu Glu Ala 
            260                 265                 270         


Ala Glu Glu Leu Gly Leu Thr Asp Gly Ser Leu Val Phe Leu Pro Phe 
        275                 280                 285             


Asp Thr Ile His Tyr Ala Leu Ser Pro Gly Pro Glu Ala Leu Ala Ala 
    290                 295                 300                 


Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala His Asp Ala Val Leu Thr 
305                 310                 315                 320 


Leu Thr Arg His Cys Pro Ser Glu Gly Ser Val Leu Asp Ser Leu Arg 
                325                 330                 335     


Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser Asp Leu Asn Leu Gln Gln 
            340                 345                 350         


Val Ser Pro Leu Phe Gly Thr Ile Tyr Asp Ala Val Phe Leu Leu Ala 
        355                 360                 365             


Arg Gly Val Ala Glu Ala Arg Ala Ala Ala Gly Gly Arg Trp Val Ser 
    370                 375                 380                 


Gly Ala Ala Val Ala Arg His Ile Arg Asp Ala Gln Val Pro Gly Phe 
385                 390                 395                 400 


Cys Gly Asp Leu Gly Gly Asp Glu Glu Pro Pro Phe Val Leu Leu Asp 
                405                 410                 415     


Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala Thr Tyr Met Leu Asp Pro 
            420                 425                 430         


Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr Arg Met His Phe Pro Arg 
        435                 440                 445             


Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser Cys Trp Phe Asp Pro Asn 
    450                 455                 460                 


Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly Leu Val Phe Leu Gly Phe 
465                 470                 475                 480 


Leu Leu Val Val Gly Met Gly Leu Ala Gly Ala Phe Leu Ala His Tyr 
                485                 490                 495     


Val Arg His Arg Leu Leu His Met Gln Met Val Ser Gly Pro Asn Lys 
            500                 505                 510         


Ile Ile Leu Thr Val Asp Asp Ile Thr Phe Leu His Pro His Gly Gly 
        515                 520                 525             


Thr Ser Arg Lys Val Ala Gln Gly Ser Arg Ser Ser Leu Gly Ala Arg 
    530                 535                 540                 


Ser Met Ser Asp Ile Arg Ser Gly Pro Ser Gln His Leu Asp Ser Pro 
545                 550                 555                 560 


Asn Ile Gly Val Tyr Glu Gly Asp Arg Val Trp Leu Lys Lys Phe Pro 
                565                 570                 575     


Gly Asp Gln His Ile Ala Ile Arg Pro Ala Thr Lys Thr Ala Phe Ser 
            580                 585                 590         


Lys Leu Gln Glu Leu Arg His Glu Asn Val Ala Leu Tyr Leu Gly Leu 
        595                 600                 605             


Phe Leu Ala Arg Gly Ala Glu Gly Pro Ala Ala Leu Trp Glu Gly Asn 
    610                 615                 620                 


Leu Ala Val Val Ser Glu His Cys Thr Arg Gly Ser Leu Gln Asp Leu 
625                 630                 635                 640 


Leu Ala Gln Arg Glu Ile Lys Leu Asp Trp Met Phe Lys Ser Ser Leu 
                645                 650                 655     


Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr Leu His His Arg Gly Val 
            660                 665                 670         


Ala His Gly Arg Leu Lys Ser Arg Asn Cys Ile Val Asp Gly Arg Phe 
        675                 680                 685             


Val Leu Lys Ile Thr Asp His Gly His Gly Arg Leu Leu Glu Ala Gln 
    690                 695                 700                 


Lys Val Leu Pro Glu Pro Pro Arg Ala Glu Asp Gln Leu Trp Thr Ala 
705                 710                 715                 720 


Pro Glu Leu Leu Arg Asp Pro Ala Leu Glu Arg Arg Gly Thr Leu Ala 
                725                 730                 735     


Gly Asp Val Phe Ser Leu Ala Ile Ile Met Gln Glu Val Val Cys Arg 
            740                 745                 750         


Ser Ala Pro Tyr Ala Met Leu Glu Leu Thr Pro Glu Glu Val Val Gln 
        755                 760                 765             


Arg Val Arg Ser Pro Pro Pro Leu Cys Arg Pro Leu Val Ser Met Asp 
    770                 775                 780                 


Gln Ala Pro Val Glu Cys Ile Leu Leu Met Lys Gln Cys Trp Ala Glu 
785                 790                 795                 800 


Gln Pro Glu Leu Arg Pro Ser Met Asp His Thr Phe Asp Leu Phe Lys 
                805                 810                 815     


Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile Ile Asp Ser Met Leu Arg 
            820                 825                 830         


Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu Asp Leu Ile Arg Glu Arg 
        835                 840                 845             


Thr Glu Glu Leu Glu Leu Glu Lys Gln Lys Thr Asp Arg Leu Leu Thr 
    850                 855                 860                 


Gln Met Leu Pro Pro Ser Val Ala Glu Ala Leu Lys Thr Gly Thr Pro 
865                 870                 875                 880 


Val Glu Pro Glu Tyr Phe Glu Gln Val Thr Leu Tyr Phe Ser Asp Ile 
                885                 890                 895     


Val Gly Phe Thr Thr Ile Ser Ala Met Ser Glu Pro Ile Glu Val Val 
            900                 905                 910         


Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe Asp Ala Ile Ile Gly Ser 
        915                 920                 925             


His Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala 
    930                 935                 940                 


Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg His Ala Ala Glu Ile Ala 
945                 950                 955                 960 


Asn Met Ser Leu Asp Ile Leu Ser Ala Val Gly Thr Phe Arg Met Arg 
                965                 970                 975     


His Met Pro Glu Val Pro Val Arg Ile Arg Ile Gly Leu His Ser Gly 
            980                 985                 990         


Pro Cys Val Ala Gly Val Val Gly  Leu Thr Met Pro Arg  Tyr Cys Leu 
        995                 1000                 1005             


Phe Gly  Asp Thr Val Asn Thr  Ala Ser Arg Met Glu  Ser Thr Gly 
    1010                 1015                 1020             


Leu Pro  Tyr Arg Ile His Val  Asn Leu Ser Thr Val  Gly Ile Leu 
    1025                 1030                 1035             


Arg Ala  Leu Asp Ser Gly Tyr  Gln Val Glu Leu Arg  Gly Arg Thr 
    1040                 1045                 1050             


Glu Leu  Lys Gly Lys Gly Ala  Glu Asp Thr Phe Trp  Leu Val Gly 
    1055                 1060                 1065             


Arg Arg  Gly Phe Asn Lys Pro  Ile Pro Lys Pro Pro  Asp Leu Gln 
    1070                 1075                 1080             


Pro Gly  Ser Ser Asn His Gly  Ile Ser Leu Gln Glu  Ile Pro Pro 
    1085                 1090                 1095             


Glu Arg  Arg Arg Lys Leu Glu  Lys Ala Arg Pro Gly  Gln Phe Ser 
    1100                 1105                 1110             


<210> 35
<211> 1113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Ala Val Phe 
    50                  55                  60                  


Thr Val Gly Val Leu Gly Pro Trp Ala Cys Asp Pro Ile Phe Ser Arg 
65                  70                  75                  80  


Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala Ala Ala Arg Leu Asn Arg 
                85                  90                  95      


Asp Pro Gly Leu Ala Gly Gly Pro Arg Phe Glu Val Ala Leu Leu Pro 
            100                 105                 110         


Glu Pro Cys Arg Thr Pro Gly Ser Leu Gly Ala Val Ser Ser Ala Leu 
        115                 120                 125             


Ala Arg Val Ser Gly Leu Val Gly Pro Val Asn Pro Ala Ala Cys Arg 
    130                 135                 140                 


Pro Ala Glu Leu Leu Ala Glu Glu Ala Gly Ile Ala Leu Val Pro Trp 
145                 150                 155                 160 


Gly Cys Pro Trp Thr Gln Ala Glu Gly Thr Thr Ala Pro Ala Val Thr 
                165                 170                 175     


Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu Arg Ala Phe Gly Trp Ala 
            180                 185                 190         


Arg Val Ala Leu Val Thr Ala Pro Gln Asp Leu Trp Val Glu Ala Gly 
        195                 200                 205             


Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg Gly Leu Pro Val Ala Ser 
    210                 215                 220                 


Val Thr Ser Met Glu Pro Leu Asp Leu Ser Gly Ala Arg Glu Ala Leu 
225                 230                 235                 240 


Arg Lys Val Arg Asp Gly Pro Arg Val Thr Ala Val Ile Met Val Met 
                245                 250                 255     


His Ser Val Leu Leu Gly Gly Glu Glu Gln Arg Tyr Leu Leu Glu Ala 
            260                 265                 270         


Ala Glu Glu Leu Gly Leu Thr Asp Gly Ser Leu Val Phe Leu Pro Phe 
        275                 280                 285             


Asp Thr Ile His Tyr Ala Leu Ser Pro Gly Pro Glu Ala Leu Ala Ala 
    290                 295                 300                 


Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala His Asp Ala Val Leu Thr 
305                 310                 315                 320 


Leu Thr Arg His Cys Pro Ser Glu Gly Ser Val Leu Asp Ser Leu Arg 
                325                 330                 335     


Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser Asp Leu Asn Leu Gln Gln 
            340                 345                 350         


Val Ser Pro Leu Phe Gly Thr Ile Tyr Asp Ala Val Phe Leu Leu Ala 
        355                 360                 365             


Arg Gly Val Ala Glu Ala Arg Ala Ala Ala Gly Gly Arg Trp Val Ser 
    370                 375                 380                 


Gly Ala Ala Val Ala Arg His Ile Arg Asp Ala Gln Val Pro Gly Phe 
385                 390                 395                 400 


Cys Gly Asp Leu Gly Gly Asp Glu Glu Pro Pro Phe Val Leu Leu Asp 
                405                 410                 415     


Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala Thr Tyr Met Leu Asp Pro 
            420                 425                 430         


Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr Arg Met His Phe Pro Arg 
        435                 440                 445             


Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser Cys Trp Phe Asp Pro Asn 
    450                 455                 460                 


Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly Leu Val Phe Leu Gly Phe 
465                 470                 475                 480 


Leu Leu Val Val Gly Met Gly Leu Ala Gly Ala Phe Leu Ala His Tyr 
                485                 490                 495     


Val Arg His Arg Leu Leu His Met Gln Met Val Ser Gly Pro Asn Lys 
            500                 505                 510         


Ile Ile Leu Thr Val Asp Asp Ile Thr Phe Leu His Pro His Gly Gly 
        515                 520                 525             


Thr Ser Arg Lys Val Ala Gln Gly Ser Arg Ser Ser Leu Gly Ala Arg 
    530                 535                 540                 


Ser Met Ser Asp Ile Arg Ser Gly Pro Ser Gln His Leu Asp Ser Pro 
545                 550                 555                 560 


Asn Ile Gly Val Tyr Glu Gly Asp Arg Val Trp Leu Lys Lys Phe Pro 
                565                 570                 575     


Gly Asp Gln His Ile Ala Ile Arg Pro Ala Thr Lys Thr Ala Phe Ser 
            580                 585                 590         


Lys Leu Gln Glu Leu Arg His Glu Asn Val Ala Leu Tyr Leu Gly Leu 
        595                 600                 605             


Phe Leu Ala Arg Gly Ala Glu Gly Pro Ala Ala Leu Trp Glu Gly Asn 
    610                 615                 620                 


Leu Ala Val Val Ser Glu His Cys Thr Arg Gly Ser Leu Gln Asp Leu 
625                 630                 635                 640 


Leu Ala Gln Arg Glu Ile Lys Leu Asp Trp Met Phe Lys Ser Ser Leu 
                645                 650                 655     


Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr Leu His His Arg Gly Val 
            660                 665                 670         


Ala His Gly Arg Leu Lys Ser Arg Asn Cys Ile Val Asp Gly Arg Phe 
        675                 680                 685             


Val Leu Lys Ile Thr Asp His Gly His Gly Arg Leu Leu Glu Ala Gln 
    690                 695                 700                 


Lys Val Leu Pro Glu Pro Pro Arg Ala Glu Asp Gln Leu Trp Thr Ala 
705                 710                 715                 720 


Pro Glu Leu Leu Arg Asp Pro Ala Leu Glu Arg Arg Gly Thr Leu Ala 
                725                 730                 735     


Gly Asp Val Phe Ser Leu Ala Ile Ile Met Gln Glu Val Val Cys Arg 
            740                 745                 750         


Ser Ala Pro Tyr Ala Met Leu Glu Leu Thr Pro Glu Glu Val Val Gln 
        755                 760                 765             


Arg Val Arg Ser Pro Pro Pro Leu Cys Arg Pro Leu Val Ser Met Asp 
    770                 775                 780                 


Gln Ala Pro Val Glu Cys Ile Leu Leu Met Lys Gln Cys Trp Ala Glu 
785                 790                 795                 800 


Gln Pro Glu Leu Arg Pro Ser Met Asp His Thr Phe Asp Leu Phe Lys 
                805                 810                 815     


Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile Ile Asp Ser Met Leu Arg 
            820                 825                 830         


Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu Asp Leu Ile Arg Glu Arg 
        835                 840                 845             


Thr Glu Glu Leu Glu Leu Glu Lys Gln Lys Thr Asp Arg Leu Leu Thr 
    850                 855                 860                 


Gln Met Leu Pro Pro Ser Val Ala Glu Ala Leu Lys Thr Gly Thr Pro 
865                 870                 875                 880 


Val Glu Pro Glu Tyr Phe Glu Gln Val Thr Leu Tyr Phe Ser Asp Ile 
                885                 890                 895     


Val Gly Phe Thr Thr Ile Ser Ala Met Ser Glu Pro Ile Glu Val Val 
            900                 905                 910         


Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe Asp Ala Ile Ile Gly Ser 
        915                 920                 925             


His Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala 
    930                 935                 940                 


Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg His Ala Ala Glu Ile Ala 
945                 950                 955                 960 


Asn Met Ser Leu Asp Ile Leu Ser Ala Val Gly Thr Phe Arg Met Arg 
                965                 970                 975     


His Met Pro Glu Val Pro Val Arg Ile Arg Ile Gly Leu His Ser Gly 
            980                 985                 990         


Pro Cys Val Ala Gly Val Val Gly  Leu Thr Met Pro Arg  Tyr Cys Leu 
        995                 1000                 1005             


Phe Gly  Asp Thr Val Asn Thr  Ala Ser Arg Met Glu  Ser Thr Gly 
    1010                 1015                 1020             


Leu Pro  Tyr Arg Ile His Val  Asn Leu Ser Thr Val  Gly Ile Leu 
    1025                 1030                 1035             


Arg Ala  Leu Asp Ser Gly Tyr  Gln Val Glu Leu Arg  Gly Arg Thr 
    1040                 1045                 1050             


Glu Leu  Lys Gly Lys Gly Ala  Glu Asp Thr Phe Trp  Leu Val Gly 
    1055                 1060                 1065             


Arg Arg  Gly Phe Asn Lys Pro  Ile Pro Lys Pro Pro  Asp Leu Gln 
    1070                 1075                 1080             


Pro Gly  Ser Ser Asn His Gly  Ile Ser Leu Gln Glu  Ile Pro Pro 
    1085                 1090                 1095             


Glu Arg  Arg Arg Lys Leu Glu  Lys Ala Arg Pro Gly  Gln Phe Ser 
    1100                 1105                 1110             


<210> 36
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Thr Gly Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe 
1               5                   10                  15      


Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu 
            20                  25                  30          


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala 
        35                  40                  45              


Thr Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe 
    50                  55                  60                  


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln 
65                  70                  75                  80  


Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile 
                85                  90                  95      


Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys 
            100                 105                 110         


Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg 
        115                 120                 125             


Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr 
    130                 135                 140                 


Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln 
145                 150                 155                 160 


Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
            180                 185                 190         


Leu Val Ser Ser Leu Ser Pro Gln His Ser Ala Val Thr Gln Gly Ile 
        195                 200                 205             


Ile Lys Asn Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala Trp Ser 
    210                 215                 220                 


Arg Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg Glu 
225                 230                 235                 240 


Glu Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn Val 
                245                 250                 255     


Met Leu Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr 
            260                 265                 270         


Lys Pro Asp Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu 
        275                 280                 285             


Val Glu Arg Glu Ile His Gln Glu Thr His Pro Asp Ser Glu Thr Ala 
    290                 295                 300                 


Phe Glu Ile Lys Ser Ser Val 
305                 310     


<210> 37
<211> 372
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Thr Gly Ala 
    50                  55                  60                  


Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg 
65                  70                  75                  80  


Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln 
            100                 105                 110         


Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg 
        115                 120                 125             


Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile 
    130                 135                 140                 


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
145                 150                 155                 160 


Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr 
                165                 170                 175     


Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            180                 185                 190         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        195                 200                 205             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    210                 215                 220                 


Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Ser 
                245                 250                 255     


Ser Leu Ser Pro Gln His Ser Ala Val Thr Gln Gly Ile Ile Lys Asn 
            260                 265                 270         


Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu 
        275                 280                 285             


Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys 
    290                 295                 300                 


Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu 
305                 310                 315                 320 


Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp 
                325                 330                 335     


Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val Glu Arg 
            340                 345                 350         


Glu Ile His Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe Glu Ile 
        355                 360                 365             


Lys Ser Ser Val 
    370         


<210> 38
<211> 372
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Thr Gly Ala 
    50                  55                  60                  


Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg 
65                  70                  75                  80  


Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln 
            100                 105                 110         


Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg 
        115                 120                 125             


Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile 
    130                 135                 140                 


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
145                 150                 155                 160 


Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr 
                165                 170                 175     


Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            180                 185                 190         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        195                 200                 205             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    210                 215                 220                 


Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Ser 
                245                 250                 255     


Ser Leu Ser Pro Gln His Ser Ala Val Thr Gln Gly Ile Ile Lys Asn 
            260                 265                 270         


Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu 
        275                 280                 285             


Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys 
    290                 295                 300                 


Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu 
305                 310                 315                 320 


Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp 
                325                 330                 335     


Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val Glu Arg 
            340                 345                 350         


Glu Ile His Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe Glu Ile 
        355                 360                 365             


Lys Ser Ser Val 
    370         


<210> 39
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Thr Gly Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe 
1               5                   10                  15      


Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu 
            20                  25                  30          


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala 
        35                  40                  45              


Thr Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe 
    50                  55                  60                  


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln 
65                  70                  75                  80  


Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile 
                85                  90                  95      


Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys 
            100                 105                 110         


Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg 
        115                 120                 125             


Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr 
    130                 135                 140                 


Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln 
145                 150                 155                 160 


Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
            180                 185                 190         


Leu Val Gly Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg 
        195                 200                 205             


Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr 
    210                 215                 220                 


Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln 
225                 230                 235                 240 


Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg 
                245                 250                 255     


Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr 
            260                 265                 270         


Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys 
        275                 280                 285             


Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His 
    290                 295                 300                 


Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys 
305                 310                 315                 320 


Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr 
                325                 330                 335     


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
            340                 345                 350         


Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln 
        355                 360                 365             


Lys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gln Leu Val Ser Ser Leu Ser Pro Gln His Ser Ala Val Thr Gln 
385                 390                 395                 400 


Gly Ile Ile Lys Asn Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala 
                405                 410                 415     


Trp Ser Arg Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr 
            420                 425                 430         


Arg Glu Glu Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg 
        435                 440                 445             


Asn Val Met Leu Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln 
    450                 455                 460                 


Leu Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro 
465                 470                 475                 480 


Trp Leu Val Glu Arg Glu Ile His Gln Glu Thr His Pro Asp Ser Glu 
                485                 490                 495     


Thr Ala Phe Glu Ile Lys Ser Ser Val 
            500                 505 


<210> 40
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Thr Gly Ala 
    50                  55                  60                  


Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg 
65                  70                  75                  80  


Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln 
            100                 105                 110         


Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg 
        115                 120                 125             


Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile 
    130                 135                 140                 


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
145                 150                 155                 160 


Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr 
                165                 170                 175     


Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            180                 185                 190         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        195                 200                 205             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    210                 215                 220                 


Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Gly 
                245                 250                 255     


Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            260                 265                 270         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        275                 280                 285             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    290                 295                 300                 


Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln 
305                 310                 315                 320 


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg 
                325                 330                 335     


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
            340                 345                 350         


Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile 
        355                 360                 365             


His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
    370                 375                 380                 


Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly 
385                 390                 395                 400 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg 
                405                 410                 415     


Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu 
        435                 440                 445             


Val Ser Ser Leu Ser Pro Gln His Ser Ala Val Thr Gln Gly Ile Ile 
    450                 455                 460                 


Lys Asn Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg 
465                 470                 475                 480 


Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu 
                485                 490                 495     


Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn Val Met 
            500                 505                 510         


Leu Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys 
        515                 520                 525             


Pro Asp Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val 
    530                 535                 540                 


Glu Arg Glu Ile His Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe 
545                 550                 555                 560 


Glu Ile Lys Ser Ser Val 
                565     


<210> 41
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Thr Gly Ala 
    50                  55                  60                  


Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg 
65                  70                  75                  80  


Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln 
            100                 105                 110         


Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg 
        115                 120                 125             


Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile 
    130                 135                 140                 


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
145                 150                 155                 160 


Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr 
                165                 170                 175     


Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            180                 185                 190         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        195                 200                 205             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    210                 215                 220                 


Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Gly 
                245                 250                 255     


Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            260                 265                 270         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        275                 280                 285             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    290                 295                 300                 


Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln 
305                 310                 315                 320 


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg 
                325                 330                 335     


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
            340                 345                 350         


Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile 
        355                 360                 365             


His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
    370                 375                 380                 


Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly 
385                 390                 395                 400 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg 
                405                 410                 415     


Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu 
        435                 440                 445             


Val Ser Ser Leu Ser Pro Gln His Ser Ala Val Thr Gln Gly Ile Ile 
    450                 455                 460                 


Lys Asn Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg 
465                 470                 475                 480 


Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu 
                485                 490                 495     


Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn Val Met 
            500                 505                 510         


Leu Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys 
        515                 520                 525             


Pro Asp Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val 
    530                 535                 540                 


Glu Arg Glu Ile His Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe 
545                 550                 555                 560 


Glu Ile Lys Ser Ser Val 
                565     


<210> 42
<211> 699
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Thr Gly Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe 
1               5                   10                  15      


Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu 
            20                  25                  30          


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala 
        35                  40                  45              


Thr Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe 
    50                  55                  60                  


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln 
65                  70                  75                  80  


Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile 
                85                  90                  95      


Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys 
            100                 105                 110         


Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg 
        115                 120                 125             


Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr 
    130                 135                 140                 


Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln 
145                 150                 155                 160 


Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
            180                 185                 190         


Leu Val Gly Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg 
        195                 200                 205             


Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr 
    210                 215                 220                 


Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln 
225                 230                 235                 240 


Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg 
                245                 250                 255     


Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr 
            260                 265                 270         


Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys 
        275                 280                 285             


Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His 
    290                 295                 300                 


Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys 
305                 310                 315                 320 


Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr 
                325                 330                 335     


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
            340                 345                 350         


Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln 
        355                 360                 365             


Lys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gln Leu Val Gly Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys 
385                 390                 395                 400 


Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
            420                 425                 430         


Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr Gly Ser 
        435                 440                 445             


Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg 
    450                 455                 460                 


Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
465                 470                 475                 480 


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln 
                485                 490                 495     


Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg 
            500                 505                 510         


Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile 
        515                 520                 525             


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
    530                 535                 540                 


Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Leu 
545                 550                 555                 560 


Arg Gln Lys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gln Leu Val Ser Ser Leu Ser Pro Gln His Ser Ala Val 
            580                 585                 590         


Thr Gln Gly Ile Ile Lys Asn Lys Glu Gly Met Asp Ala Lys Ser Leu 
        595                 600                 605             


Thr Ala Trp Ser Arg Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp 
    610                 615                 620                 


Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val 
625                 630                 635                 640 


Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly 
                645                 650                 655     


Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Lys Gly Glu 
            660                 665                 670         


Glu Pro Trp Leu Val Glu Arg Glu Ile His Gln Glu Thr His Pro Asp 
        675                 680                 685             


Ser Glu Thr Ala Phe Glu Ile Lys Ser Ser Val 
    690                 695                 


<210> 43
<211> 760
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Thr Gly Ala 
    50                  55                  60                  


Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg 
65                  70                  75                  80  


Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln 
            100                 105                 110         


Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg 
        115                 120                 125             


Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile 
    130                 135                 140                 


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
145                 150                 155                 160 


Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr 
                165                 170                 175     


Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            180                 185                 190         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        195                 200                 205             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    210                 215                 220                 


Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Gly 
                245                 250                 255     


Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            260                 265                 270         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        275                 280                 285             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    290                 295                 300                 


Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln 
305                 310                 315                 320 


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg 
                325                 330                 335     


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
            340                 345                 350         


Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile 
        355                 360                 365             


His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
    370                 375                 380                 


Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly 
385                 390                 395                 400 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg 
                405                 410                 415     


Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu 
        435                 440                 445             


Val Gly Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
    450                 455                 460                 


Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly 
465                 470                 475                 480 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg 
                485                 490                 495     


Ala Thr Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro 
            500                 505                 510         


Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu 
        515                 520                 525             


Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
    530                 535                 540                 


Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr 
545                 550                 555                 560 


Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met 
                565                 570                 575     


Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His 
            580                 585                 590         


Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala 
        595                 600                 605             


Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys 
    610                 615                 620                 


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gln Leu Val Ser Ser Leu Ser Pro Gln His Ser Ala Val Thr Gln Gly 
                645                 650                 655     


Ile Ile Lys Asn Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala Trp 
            660                 665                 670         


Ser Arg Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg 
        675                 680                 685             


Glu Glu Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn 
    690                 695                 700                 


Val Met Leu Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu 
705                 710                 715                 720 


Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Trp 
                725                 730                 735     


Leu Val Glu Arg Glu Ile His Gln Glu Thr His Pro Asp Ser Glu Thr 
            740                 745                 750         


Ala Phe Glu Ile Lys Ser Ser Val 
        755                 760 


<210> 44
<211> 760
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Thr Gly Ala 
    50                  55                  60                  


Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg 
65                  70                  75                  80  


Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln 
            100                 105                 110         


Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg 
        115                 120                 125             


Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile 
    130                 135                 140                 


Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
145                 150                 155                 160 


Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Thr 
                165                 170                 175     


Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            180                 185                 190         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        195                 200                 205             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    210                 215                 220                 


Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Gly 
                245                 250                 255     


Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
            260                 265                 270         


Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly Glu Lys 
        275                 280                 285             


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr 
    290                 295                 300                 


Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln 
305                 310                 315                 320 


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg 
                325                 330                 335     


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
            340                 345                 350         


Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile 
        355                 360                 365             


His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
    370                 375                 380                 


Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly 
385                 390                 395                 400 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg 
                405                 410                 415     


Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys Asp Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu 
        435                 440                 445             


Val Gly Thr Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
    450                 455                 460                 


Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His Thr Gly 
465                 470                 475                 480 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Arg 
                485                 490                 495     


Ala Thr Leu Gln Arg His Thr Lys Ile His Thr Gly Ser Glu Arg Pro 
            500                 505                 510         


Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Arg Ala Thr Leu 
        515                 520                 525             


Gln Arg His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
    530                 535                 540                 


Ile Cys Gly Arg Lys Phe Ala Gln Arg Ala Thr Leu Gln Arg His Thr 
545                 550                 555                 560 


Lys Ile His Thr Gly Ser Glu Arg Pro Phe Gln Cys Arg Ile Cys Met 
                565                 570                 575     


Arg Asn Phe Ser Gln Arg Ala Thr Leu Gln Arg His Ile Arg Thr His 
            580                 585                 590         


Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala 
        595                 600                 605             


Gln Arg Ala Thr Leu Gln Arg His Thr Lys Ile His Leu Arg Gln Lys 
    610                 615                 620                 


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gln Leu Val Ser Ser Leu Ser Pro Gln His Ser Ala Val Thr Gln Gly 
                645                 650                 655     


Ile Ile Lys Asn Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala Trp 
            660                 665                 670         


Ser Arg Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg 
        675                 680                 685             


Glu Glu Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn 
    690                 695                 700                 


Val Met Leu Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu 
705                 710                 715                 720 


Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Trp 
                725                 730                 735     


Leu Val Glu Arg Glu Ile His Gln Glu Thr His Pro Asp Ser Glu Thr 
            740                 745                 750         


Ala Phe Glu Ile Lys Ser Ser Val 
        755                 760 


<210> 45
<211> 653
<212> PRT
<213> Homo sapiens

<400> 45
Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210> 46
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Met Arg Pro 
    50                  55                  60                  


Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser Leu Leu Ala 
65                  70                  75                  80  


Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val His Val Asp 
                85                  90                  95      


Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg Ser Thr Gly 
            100                 105                 110         


Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr Val Leu Ser 
        115                 120                 125             


Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val Pro His Arg 
    130                 135                 140                 


Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu Val Thr Thr 
145                 150                 155                 160 


Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr His Leu Asp 
                165                 170                 175     


Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro Gly Phe Glu 
            180                 185                 190         


Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu Asp Lys Gln 
        195                 200                 205             


Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala Arg Arg Tyr 
    210                 215                 220                 


Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn Phe Glu Thr 
225                 230                 235                 240 


Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser Met Thr Met 
                245                 250                 255     


Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly Leu Arg Ala 
            260                 265                 270         


Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser Phe His Thr 
        275                 280                 285             


Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His Cys His Asp 
    290                 295                 300                 


Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu Asp Tyr Ile 
305                 310                 315                 320 


Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile Leu Glu Gln 
                325                 330                 335     


Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro Lys Phe Ala 
            340                 345                 350         


Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val Gly Trp Ser 
        355                 360                 365             


Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala Met Val Val 
    370                 375                 380                 


Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn Thr Thr Ser 
385                 390                 395                 400 


Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe Leu Ser Tyr 
                405                 410                 415     


His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg Phe Gln Val 
            420                 425                 430         


Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys Pro Val Leu 
        435                 440                 445             


Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln Leu Trp Ala 
    450                 455                 460                 


Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His Thr Val Gly 
465                 470                 475                 480 


Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp Ala Trp Arg 
                485                 490                 495     


Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala His Pro Asn 
            500                 505                 510         


Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro Pro Gly Pro 
        515                 520                 525             


Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu Cys Ser Pro 
    530                 535                 540                 


Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro Thr Ala Glu 
545                 550                 555                 560 


Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala Ala Ala Pro 
                565                 570                 575     


Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro Ala Leu Arg 
            580                 585                 590         


Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro Glu Lys Pro 
        595                 600                 605             


Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr Gln Gly Gln 
    610                 615                 620                 


Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys Cys Leu Trp 
625                 630                 635                 640 


Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr Thr Pro Val 
                645                 650                 655     


Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser Pro Asp Thr 
            660                 665                 670         


Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp Tyr Trp Ala 
        675                 680                 685             


Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu Val Pro Val 
    690                 695                 700                 


Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
705                 710                 


<210> 47
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Met Arg Pro 
    50                  55                  60                  


Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser Leu Leu Ala 
65                  70                  75                  80  


Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val His Val Asp 
                85                  90                  95      


Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg Ser Thr Gly 
            100                 105                 110         


Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr Val Leu Ser 
        115                 120                 125             


Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val Pro His Arg 
    130                 135                 140                 


Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu Val Thr Thr 
145                 150                 155                 160 


Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr His Leu Asp 
                165                 170                 175     


Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro Gly Phe Glu 
            180                 185                 190         


Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu Asp Lys Gln 
        195                 200                 205             


Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala Arg Arg Tyr 
    210                 215                 220                 


Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn Phe Glu Thr 
225                 230                 235                 240 


Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser Met Thr Met 
                245                 250                 255     


Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly Leu Arg Ala 
            260                 265                 270         


Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser Phe His Thr 
        275                 280                 285             


Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His Cys His Asp 
    290                 295                 300                 


Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu Asp Tyr Ile 
305                 310                 315                 320 


Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile Leu Glu Gln 
                325                 330                 335     


Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro Lys Phe Ala 
            340                 345                 350         


Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val Gly Trp Ser 
        355                 360                 365             


Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala Met Val Val 
    370                 375                 380                 


Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn Thr Thr Ser 
385                 390                 395                 400 


Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe Leu Ser Tyr 
                405                 410                 415     


His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg Phe Gln Val 
            420                 425                 430         


Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys Pro Val Leu 
        435                 440                 445             


Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln Leu Trp Ala 
    450                 455                 460                 


Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His Thr Val Gly 
465                 470                 475                 480 


Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp Ala Trp Arg 
                485                 490                 495     


Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala His Pro Asn 
            500                 505                 510         


Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro Pro Gly Pro 
        515                 520                 525             


Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu Cys Ser Pro 
    530                 535                 540                 


Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro Thr Ala Glu 
545                 550                 555                 560 


Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala Ala Ala Pro 
                565                 570                 575     


Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro Ala Leu Arg 
            580                 585                 590         


Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro Glu Lys Pro 
        595                 600                 605             


Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr Gln Gly Gln 
    610                 615                 620                 


Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys Cys Leu Trp 
625                 630                 635                 640 


Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr Thr Pro Val 
                645                 650                 655     


Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser Pro Asp Thr 
            660                 665                 670         


Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp Tyr Trp Ala 
        675                 680                 685             


Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu Val Pro Val 
    690                 695                 700                 


Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
705                 710                 


<210> 48
<211> 550
<212> PRT
<213> Homo sapiens

<400> 48
Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210> 49
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
1               5                   10                  15      


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
            20                  25                  30          


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Met Pro Pro 
    50                  55                  60                  


Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val Leu Ser Ser 
65                  70                  75                  80  


Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp 
                85                  90                  95      


Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu 
            100                 105                 110         


Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu 
        115                 120                 125             


Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val 
    130                 135                 140                 


Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr 
145                 150                 155                 160 


Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn 
                165                 170                 175     


Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met 
            180                 185                 190         


Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp 
        195                 200                 205             


Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu 
    210                 215                 220                 


Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His 
225                 230                 235                 240 


Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr 
                245                 250                 255     


Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys 
            260                 265                 270         


Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys 
        275                 280                 285             


Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro 
    290                 295                 300                 


Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu 
305                 310                 315                 320 


Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp 
                325                 330                 335     


Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp 
            340                 345                 350         


Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu 
        355                 360                 365             


Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu 
    370                 375                 380                 


Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu 
385                 390                 395                 400 


Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr 
                405                 410                 415     


His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro 
            420                 425                 430         


Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala 
        435                 440                 445             


Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu 
    450                 455                 460                 


Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro 
465                 470                 475                 480 


Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly 
                485                 490                 495     


Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro 
            500                 505                 510         


Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro 
        515                 520                 525             


Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys 
    530                 535                 540                 


Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr 
545                 550                 555                 560 


Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser 
                565                 570                 575     


Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln 
            580                 585                 590         


Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu 
        595                 600                 605             


Leu Met Pro 
    610     


<210> 50
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15      


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
            20                  25                  30          


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
        35                  40                  45              


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Met Pro Pro 
    50                  55                  60                  


Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val Leu Ser Ser 
65                  70                  75                  80  


Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp 
                85                  90                  95      


Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg Pro Ser Leu 
            100                 105                 110         


Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile Asp Gln Leu 
        115                 120                 125             


Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln Gln Ala Val 
    130                 135                 140                 


Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr 
145                 150                 155                 160 


Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His Ala Gly Asn 
                165                 170                 175     


Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met 
            180                 185                 190         


Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn His Thr Asp 
        195                 200                 205             


Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro Ser Ser Glu 
    210                 215                 220                 


Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly Glu Leu His 
225                 230                 235                 240 


Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro Glu Gly Thr 
                245                 250                 255     


Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys 
            260                 265                 270         


Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly Tyr His Lys 
        275                 280                 285             


Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro 
    290                 295                 300                 


Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro Asp Gly Leu 
305                 310                 315                 320 


Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln Arg Glu Asp 
                325                 330                 335     


Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile Pro Val Asp 
            340                 345                 350         


Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu 
        355                 360                 365             


Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu 
    370                 375                 380                 


Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly Trp Ala Leu 
385                 390                 395                 400 


Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr 
                405                 410                 415     


His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro 
            420                 425                 430         


Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala 
        435                 440                 445             


Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu Val Glu Leu 
    450                 455                 460                 


Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu Gln Val Pro 
465                 470                 475                 480 


Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys Arg Glu Gly 
                485                 490                 495     


Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro 
            500                 505                 510         


Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro 
        515                 520                 525             


Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys 
    530                 535                 540                 


Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr 
545                 550                 555                 560 


Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser 
                565                 570                 575     


Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln 
            580                 585                 590         


Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu 
        595                 600                 605             


Leu Met Pro 
    610     


<210> 51
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Glu Thr Phe Leu Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn 
1               5                   10                  15  


<210> 52
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Glu Thr Phe Leu 
    50                  55                  60                  


Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn 
65                  70                  75  


<210> 53
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Glu Thr Phe Leu 
    50                  55                  60                  


Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn 
65                  70                  75  


<210> 54
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn Arg His Val Lys Pro 
1               5                   10                  15  


<210> 55
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Ser Glu Leu Pro 
    50                  55                  60                  


Gly Trp Leu Gln Ala Asn Arg His Val Lys Pro 
65                  70                  75  


<210> 56
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Ser Glu Leu Pro 
    50                  55                  60                  


Gly Trp Leu Gln Ala Asn Arg His Val Lys Pro 
65                  70                  75  


<210> 57
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Trp Leu Gln Ala Asn Arg His Val Lys Pro Thr Gly Ser Ala Val 
1               5                   10                  15  


<210> 58
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Trp Leu Gln Ala 
    50                  55                  60                  


Asn Arg His Val Lys Pro Thr Gly Ser Ala Val 
65                  70                  75  


<210> 59
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Trp Leu Gln Ala 
    50                  55                  60                  


Asn Arg His Val Lys Pro Thr Gly Ser Ala Val 
65                  70                  75  


<210> 60
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Arg His Val Lys Pro Thr Gly Ser Ala Val Val Gly Leu Ser Met 
1               5                   10                  15  


<210> 61
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Arg His Val Lys 
    50                  55                  60                  


Pro Thr Gly Ser Ala Val Val Gly Leu Ser Met 
65                  70                  75  


<210> 62
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Arg His Val Lys 
    50                  55                  60                  


Pro Thr Gly Ser Ala Val Val Gly Leu Ser Met 
65                  70                  75  


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Gln Ser Gly Leu Ser Val Val Met Pro Val Gly Gly Gln Ser Ser 
1               5                   10                  15  


<210> 64
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Gln Ser Gly Leu 
    50                  55                  60                  


Ser Val Val Met Pro Val Gly Gly Gln Ser Ser 
65                  70                  75  


<210> 65
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Gln Ser Gly Leu 
    50                  55                  60                  


Ser Val Val Met Pro Val Gly Gly Gln Ser Ser 
65                  70                  75  


<210> 66
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Val Val Met Pro Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp 
1               5                   10                  15  


<210> 67
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Val Val Met Pro 
    50                  55                  60                  


Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp 
65                  70                  75  


<210> 68
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Val Val Met Pro 
    50                  55                  60                  


Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp 
65                  70                  75  


<210> 69
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp Tyr Gln Pro Ala Cys 
1               5                   10                  15  


<210> 70
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Gly Gly Gln Ser 
    50                  55                  60                  


Ser Phe Tyr Ser Asp Trp Tyr Gln Pro Ala Cys 
65                  70                  75  


<210> 71
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Gly Gly Gln Ser 
    50                  55                  60                  


Ser Phe Tyr Ser Asp Trp Tyr Gln Pro Ala Cys 
65                  70                  75  


<210> 72
<211> 296
<212> PRT
<213> Mycobacterium tuberculosis

<400> 72
Ala Phe Ser Arg Pro Gly Leu Pro Val Glu Tyr Leu Gln Val Pro Ser 
1               5                   10                  15      


Pro Ser Met Gly Arg Asp Ile Lys Val Gln Phe Gln Ser Gly Gly Ala 
            20                  25                  30          


Asn Ser Pro Ala Leu Tyr Leu Leu Asp Gly Leu Arg Ala Gln Asp Asp 
        35                  40                  45              


Phe Ser Gly Trp Asp Ile Asn Thr Pro Ala Phe Glu Trp Tyr Asp Gln 
    50                  55                  60                  


Ser Gly Leu Ser Val Val Met Pro Val Gly Gly Gln Ser Ser Phe Tyr 
65                  70                  75                  80  


Ser Asp Trp Tyr Gln Pro Ala Cys Gly Lys Ala Gly Cys Gln Thr Tyr 
                85                  90                  95      


Lys Trp Glu Thr Phe Leu Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala 
            100                 105                 110         


Asn Arg His Val Lys Pro Thr Gly Ser Ala Val Val Gly Leu Ser Met 
        115                 120                 125             


Ala Ala Ser Ser Ala Leu Thr Leu Ala Ile Tyr His Pro Gln Gln Phe 
    130                 135                 140                 


Val Tyr Ala Gly Ala Met Ser Gly Leu Leu Asp Pro Ser Gln Ala Met 
145                 150                 155                 160 


Gly Pro Thr Leu Ile Gly Leu Ala Met Gly Asp Ala Gly Gly Tyr Lys 
                165                 170                 175     


Ala Ser Asp Met Trp Gly Pro Lys Glu Asp Pro Ala Trp Gln Arg Asn 
            180                 185                 190         


Asp Pro Leu Leu Asn Val Gly Lys Leu Ile Ala Asn Asn Thr Arg Val 
        195                 200                 205             


Trp Val Tyr Cys Gly Asn Gly Lys Pro Ser Asp Leu Gly Gly Asn Asn 
    210                 215                 220                 


Leu Pro Ala Lys Phe Leu Glu Gly Phe Val Arg Thr Ser Asn Ile Lys 
225                 230                 235                 240 


Phe Gln Asp Ala Tyr Asn Ala Gly Gly Gly His Asn Gly Val Phe Asp 
                245                 250                 255     


Phe Pro Asp Ser Gly Thr His Ser Trp Glu Tyr Trp Gly Ala Gln Leu 
            260                 265                 270         


Asn Ala Met Lys Pro Asp Leu Gln Arg Ala Leu Gly Ala Thr Pro Asn 
        275                 280                 285             


Thr Gly Pro Ala Pro Gln Gly Ala 
    290                 295     


<210> 73
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Ala Phe Ser Arg 
    50                  55                  60                  


Pro Gly Leu Pro Val Glu Tyr Leu Gln Val Pro Ser Pro Ser Met Gly 
65                  70                  75                  80  


Arg Asp Ile Lys Val Gln Phe Gln Ser Gly Gly Ala Asn Ser Pro Ala 
                85                  90                  95      


Leu Tyr Leu Leu Asp Gly Leu Arg Ala Gln Asp Asp Phe Ser Gly Trp 
            100                 105                 110         


Asp Ile Asn Thr Pro Ala Phe Glu Trp Tyr Asp Gln Ser Gly Leu Ser 
        115                 120                 125             


Val Val Met Pro Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp Tyr 
    130                 135                 140                 


Gln Pro Ala Cys Gly Lys Ala Gly Cys Gln Thr Tyr Lys Trp Glu Thr 
145                 150                 155                 160 


Phe Leu Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn Arg His Val 
                165                 170                 175     


Lys Pro Thr Gly Ser Ala Val Val Gly Leu Ser Met Ala Ala Ser Ser 
            180                 185                 190         


Ala Leu Thr Leu Ala Ile Tyr His Pro Gln Gln Phe Val Tyr Ala Gly 
        195                 200                 205             


Ala Met Ser Gly Leu Leu Asp Pro Ser Gln Ala Met Gly Pro Thr Leu 
    210                 215                 220                 


Ile Gly Leu Ala Met Gly Asp Ala Gly Gly Tyr Lys Ala Ser Asp Met 
225                 230                 235                 240 


Trp Gly Pro Lys Glu Asp Pro Ala Trp Gln Arg Asn Asp Pro Leu Leu 
                245                 250                 255     


Asn Val Gly Lys Leu Ile Ala Asn Asn Thr Arg Val Trp Val Tyr Cys 
            260                 265                 270         


Gly Asn Gly Lys Pro Ser Asp Leu Gly Gly Asn Asn Leu Pro Ala Lys 
        275                 280                 285             


Phe Leu Glu Gly Phe Val Arg Thr Ser Asn Ile Lys Phe Gln Asp Ala 
    290                 295                 300                 


Tyr Asn Ala Gly Gly Gly His Asn Gly Val Phe Asp Phe Pro Asp Ser 
305                 310                 315                 320 


Gly Thr His Ser Trp Glu Tyr Trp Gly Ala Gln Leu Asn Ala Met Lys 
                325                 330                 335     


Pro Asp Leu Gln Arg Ala Leu Gly Ala Thr Pro Asn Thr Gly Pro Ala 
            340                 345                 350         


Pro Gln Gly Ala 
        355     


<210> 74
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Ala Phe Ser Arg 
    50                  55                  60                  


Pro Gly Leu Pro Val Glu Tyr Leu Gln Val Pro Ser Pro Ser Met Gly 
65                  70                  75                  80  


Arg Asp Ile Lys Val Gln Phe Gln Ser Gly Gly Ala Asn Ser Pro Ala 
                85                  90                  95      


Leu Tyr Leu Leu Asp Gly Leu Arg Ala Gln Asp Asp Phe Ser Gly Trp 
            100                 105                 110         


Asp Ile Asn Thr Pro Ala Phe Glu Trp Tyr Asp Gln Ser Gly Leu Ser 
        115                 120                 125             


Val Val Met Pro Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp Tyr 
    130                 135                 140                 


Gln Pro Ala Cys Gly Lys Ala Gly Cys Gln Thr Tyr Lys Trp Glu Thr 
145                 150                 155                 160 


Phe Leu Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn Arg His Val 
                165                 170                 175     


Lys Pro Thr Gly Ser Ala Val Val Gly Leu Ser Met Ala Ala Ser Ser 
            180                 185                 190         


Ala Leu Thr Leu Ala Ile Tyr His Pro Gln Gln Phe Val Tyr Ala Gly 
        195                 200                 205             


Ala Met Ser Gly Leu Leu Asp Pro Ser Gln Ala Met Gly Pro Thr Leu 
    210                 215                 220                 


Ile Gly Leu Ala Met Gly Asp Ala Gly Gly Tyr Lys Ala Ser Asp Met 
225                 230                 235                 240 


Trp Gly Pro Lys Glu Asp Pro Ala Trp Gln Arg Asn Asp Pro Leu Leu 
                245                 250                 255     


Asn Val Gly Lys Leu Ile Ala Asn Asn Thr Arg Val Trp Val Tyr Cys 
            260                 265                 270         


Gly Asn Gly Lys Pro Ser Asp Leu Gly Gly Asn Asn Leu Pro Ala Lys 
        275                 280                 285             


Phe Leu Glu Gly Phe Val Arg Thr Ser Asn Ile Lys Phe Gln Asp Ala 
    290                 295                 300                 


Tyr Asn Ala Gly Gly Gly His Asn Gly Val Phe Asp Phe Pro Asp Ser 
305                 310                 315                 320 


Gly Thr His Ser Trp Glu Tyr Trp Gly Ala Gln Leu Asn Ala Met Lys 
                325                 330                 335     


Pro Asp Leu Gln Arg Ala Leu Gly Ala Thr Pro Asn Thr Gly Pro Ala 
            340                 345                 350         


Pro Gln Gly Ala 
        355     


<210> 75
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
uaacagucua cagccauggu cg                                                22


<210> 76
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
tcaacatcag tctgataagc ta                                                22


<210> 77
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
tagcttatca gactgatgtt ga                                                22


<210> 78
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
cgaccatggc tgtagactgt ta                                                22


<210> 79
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
gtggtgaaag cctatgatca t                                                 21


<210> 80
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 80
His His His His His His 
1               5       


<210> 81
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210> 82
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
cggaggacag tcctccg                                                      17


<210> 83
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Ile Glu Gly Arg 
1               


<210> 84
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Asp Asp Asp Asp Lys 
1               5   


<210> 85
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Leu Val Pro Arg Gly 
1               5   


<210> 86
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(20) 
<223> This sequence may encompass 1, 2, 3, or 4 "Gly Gly Gly 
      Gly Ser" repeating units, wherein some positions may
      not be present

<400> 86
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 87
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(8) 
<223> This sequence may encompass 6 or 8 residues, wherein 
      some positions may not be present

<400> 87
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 88
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(15) 
<223> This sequence may encompass 1-3 "Glu Ala Ala Ala Lys"
      repeating units, wherein some positions may not be 
      present
      
<400> 88
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210> 89
<211> 46
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide
 
<400> 89
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210> 90
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Pro Ala Pro Ala Pro 
1               5   


<210> 91
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210> 92
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(34) 
<223> This sequence may encompass 10-34 residues, wherein some
      positions may not be present
      
<400> 92
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro 
        


<210> 93
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
1               5                   10                  15      


Val 
    


<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 94
Pro Leu Gly Leu Trp Ala Cys 
1               5           


<210> 95
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 95
Arg Val Leu Ala Glu Ala 
1               5       


<210> 96
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 96
Glu Asp Val Val Cys Cys Ser Met Ser Tyr 
1               5                   10  


<210> 97
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 97
Gly Gly Ile Glu Gly Arg Gly Ser 
1               5               


<210> 98
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 98
Thr Arg His Arg Gln Pro Arg Gly Trp Glu 
1               5                   10  


<210> 99
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 99
Ala Gly Asn Arg Val Arg Arg Ser Val Gly 
1               5                   10  


<210> 100
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 100
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 101
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 101
Gly Phe Leu Gly 
1               


<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 102
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 103
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 103
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 104
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 104
His His His His His His Gly Ser 
1               5               


<210> 105
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 105
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210> 106
<211> 338
<212> PRT
<213> Mycobacterium tuberculosis

<400> 106
Met Gln Leu Val Asp Arg Val Arg Gly Ala Val Thr Gly Met Ser Arg 
1               5                   10                  15      


Arg Leu Val Val Gly Ala Val Gly Ala Ala Leu Val Ser Gly Leu Val 
            20                  25                  30          


Gly Ala Val Gly Gly Thr Ala Thr Ala Gly Ala Phe Ser Arg Pro Gly 
        35                  40                  45              


Leu Pro Val Glu Tyr Leu Gln Val Pro Ser Pro Ser Met Gly Arg Asp 
    50                  55                  60                  


Ile Lys Val Gln Phe Gln Ser Gly Gly Ala Asn Ser Pro Ala Leu Tyr 
65                  70                  75                  80  


Leu Leu Asp Gly Leu Arg Ala Gln Asp Asp Phe Ser Gly Trp Asp Ile 
                85                  90                  95      


Asn Thr Pro Ala Phe Glu Trp Tyr Asp Gln Ser Gly Leu Ser Val Val 
            100                 105                 110         


Met Pro Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp Tyr Gln Pro 
        115                 120                 125             


Ala Cys Gly Lys Ala Gly Cys Gln Thr Tyr Lys Trp Glu Thr Phe Leu 
    130                 135                 140                 


Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn Arg His Val Lys Pro 
145                 150                 155                 160 


Thr Gly Ser Ala Val Val Gly Leu Ser Met Ala Ala Ser Ser Ala Leu 
                165                 170                 175     


Thr Leu Ala Ile Tyr His Pro Gln Gln Phe Val Tyr Ala Gly Ala Met 
            180                 185                 190         


Ser Gly Leu Leu Asp Pro Ser Gln Ala Met Gly Pro Thr Leu Ile Gly 
        195                 200                 205             


Leu Ala Met Gly Asp Ala Gly Gly Tyr Lys Ala Ser Asp Met Trp Gly 
    210                 215                 220                 


Pro Lys Glu Asp Pro Ala Trp Gln Arg Asn Asp Pro Leu Leu Asn Val 
225                 230                 235                 240 


Gly Lys Leu Ile Ala Asn Asn Thr Arg Val Trp Val Tyr Cys Gly Asn 
                245                 250                 255     


Gly Lys Pro Ser Asp Leu Gly Gly Asn Asn Leu Pro Ala Lys Phe Leu 
            260                 265                 270         


Glu Gly Phe Val Arg Thr Ser Asn Ile Lys Phe Gln Asp Ala Tyr Asn 
        275                 280                 285             


Ala Gly Gly Gly His Asn Gly Val Phe Asp Phe Pro Asp Ser Gly Thr 
    290                 295                 300                 


His Ser Trp Glu Tyr Trp Gly Ala Gln Leu Asn Ala Met Lys Pro Asp 
305                 310                 315                 320 


Leu Gln Arg Ala Leu Gly Ala Thr Pro Asn Thr Gly Pro Ala Pro Gln 
                325                 330                 335     


Gly Ala 
        


<210> 107
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 107
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln 
1               5                   10          


<210> 108
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 108
Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val 
1               5                   10              


<210> 109
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 109
Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


<210> 110
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 110
Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu 
1               5                   10          


<210> 111
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 111
Gly Ser His His His His His His 
1               5               


<210> 112
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 112
Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
1               5                   10                  15  


<210> 113
<211> 264
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(264)

<400> 113
atg gcc cat cac cac cac cat cac agc gct gca gaa aat ctg tac ttt         48
Met Ala His His His His His His Ser Ala Ala Glu Asn Leu Tyr Phe           
1               5                   10                  15                

cag agc cgt aag aag cgt aaa ccg tat tcc aaa ctg caa ctg gcg gag         96
Gln Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu           
            20                  25                  30                    

ttg gaa ggt gag ttc ctg gtt aac gaa ttc att acc cgt cag cgc cgt        144
Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg           
        35                  40                  45                        

cgc gag ctg agc gat cgc ctg aac ctg tct gac caa caa gtg aaa atc        192
Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile           
    50                  55                  60                            

tgg ttt cag aat cgt cgt atg aag aaa aag cgc ctg ctg acc gcg ttg        240
Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Thr Ala Leu           
65                  70                  75                  80            

gac tgg agc tgg ctg cag acg gag                                        264
Asp Trp Ser Trp Leu Gln Thr Glu                                           
                85                                                        


<210> 114
<211> 88
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 114
Met Ala His His His His His His Ser Ala Ala Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu 
            20                  25                  30          


Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg 
        35                  40                  45              


Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
    50                  55                  60                  


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu Thr Ala Leu 
65                  70                  75                  80  


Asp Trp Ser Trp Leu Gln Thr Glu 
                85              


<210> 115
<211> 264
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(264)

<400> 115
atg gct cat cac cac cat cac cac agc gca gcg gag aac ttg tat ttt         48
Met Ala His His His His His His Ser Ala Ala Glu Asn Leu Tyr Phe           
1               5                   10                  15                

caa gcc cgt aag aaa cgt aaa ccg tac acc aag cag caa att gcg gag         96
Gln Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu           
            20                  25                  30                    

ctg gag aat gaa ttc ctg gtc aat gaa ttc atc aac cgt cag aag cgc        144
Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg           
        35                  40                  45                        

aaa gaa ctg agc aat cgc ctg aac ctg tcc gac cag caa gtg aaa atc        192
Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile           
    50                  55                  60                            

tgg ttt caa aac cgt cgc atg aag aag aaa cgt gtt gtt acg gcg ctg        240
Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Thr Ala Leu           
65                  70                  75                  80            

gat tgg agc tgg ctg cag acc gag                                        264
Asp Trp Ser Trp Leu Gln Thr Glu                                           
                85                                                        


<210> 116
<211> 88
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 116
Met Ala His His His His His His Ser Ala Ala Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu 
            20                  25                  30          


Leu Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg 
        35                  40                  45              


Lys Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile 
    50                  55                  60                  


Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Thr Ala Leu 
65                  70                  75                  80  


Asp Trp Ser Trp Leu Gln Thr Glu 
                85              


<210> 117
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 117
Arg Val Lys Arg
1               


