                         SEQUENCE LISTING

<110>  Merck, Sharp & Dohme Corp.
       Gu, Danling
       Beebe, Amy M.
 
<120>  MODULATION OF TUMOR IMMUNITY

<130>  23565-WO-PCT

<150>  US 61/867,976
<151>  2013-08-20

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ala 
1               5                   10  


<210>  3
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  3

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn 
1               5                   10      


<210>  4
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  4

Gly Tyr Thr Phe Ser Arg Tyr Trp Ile Glu 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  5

Gly Tyr Thr Phe Thr Ser Tyr Thr Met His 
1               5                   10  


<210>  6
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly 
1               5                   10          


<210>  7
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Phe Thr Val Arg Asn Tyr Ala Met Ser 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  8

Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn 
1               5                   10  


<210>  10
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Gly Phe Ser Leu Ser Thr Tyr Gly Val Gly Val Gly 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Gly Phe Ser Leu Ser Thr Tyr Gly Val Gly Val Gly 
1               5                   10          


<210>  12
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  12

Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  13
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Tyr Ile His Ala Asn Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  14

Tyr Ile Ser Tyr Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  15

Glu Ile Leu Pro Gly Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  16
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  16

Tyr Ile Asn Pro Arg Ser Val Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  17
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  17

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  18

Ser Ile Ser Thr Gly Asp Arg Ser Tyr Leu Pro Asp Ser Met Lys Gly 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  19

Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg Gly 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  20

Phe Ile Ser Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  21

Asn Ile Trp Trp Asp Asp Asp Asn Tyr Tyr Asn Pro Ser Leu Ile His 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  23
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  23

Val Gly Gly Tyr Tyr Asp Ser Met Asp Tyr 
1               5                   10  


<210>  24
<211>  14
<212>  PRT
<213>  Rattus norvegicus

<400>  24

Gly Ser Phe Met Tyr Ala Ala Asp Tyr Tyr Ile Met Asp Ala 
1               5                   10                  


<210>  25
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  25

Gln Leu Gly Leu Arg Phe Phe Asp Tyr 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  26

Lys Val Tyr Tyr Tyr Ala Met Asp Phe 
1               5                   


<210>  27
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  27

Leu Gly Gly Tyr Tyr Asp Thr Met Asp Tyr 
1               5                   10  


<210>  28
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  28

Ser Tyr Tyr Tyr Gly Ser Ser Gly Ala Met Asp Tyr Trp Gly Gln Gly 
1               5                   10                  15      


Thr Ser Val Thr Val Ser Ser 
            20              


<210>  29
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  29

Tyr Phe Asp Phe Asp Ser Phe Ala Phe Trp Gly Gln Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ala 
            20  


<210>  30
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  30

Arg His Leu Gly Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
1               5                   10                  15      


Thr Leu Val Thr Val Ser Ala 
            20              


<210>  31
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  31

Arg His Leu Ile Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
1               5                   10                  15      


Thr Leu Val Thr Val Ser Ala 
            20              


<210>  32
<211>  22
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly Pro Gly Thr 
1               5                   10                  15      


Met Val Ser Val Ser Ser 
            20          


<210>  33
<211>  22
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly Pro Gly Thr 
1               5                   10                  15      


Met Val Ser Val Ser Ser 
            20          


<210>  34
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  34

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Val Ser Phe Met Asn 
1               5                   10                  15  


<210>  35
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  35

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Gly Asn Thr Phe Leu Ser 
1               5                   10                  15      


<210>  36
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  36

Ser Ala Asn Ser Thr Val Asn Tyr Met Tyr 
1               5                   10  


<210>  37
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  37

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Phe His 
1               5                   10          


<210>  38
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  38

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  39
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  39

Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  40
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  40

Arg Ala Ser Gln Asp Ile Asn Asn Phe Leu Asn 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  41

Lys Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  42

Lys Ala Ser Gln Asp Val Ile Ser Ala Val Ala 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  43

Arg Ala Ser Gln Gly Val Asn Asn Phe Leu Thr 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  44

Arg Ala Ser Gln Gly Val Asn Asn Tyr Leu Thr 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  45

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  46

Leu Ala Ser Asn Arg Phe Ser 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  47

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  48

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  49

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  50

Lys Val Ser Lys Arg Phe Ser 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  51

Tyr Thr Ser Lys Leu His Ser 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  52

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  53

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  54

Tyr Thr Ser Asn Leu Gln Ser 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  55

Tyr Thr Ser Asn Leu Gln Ser 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  56

Gln Gln Thr Lys Glu Val Thr Trp Thr 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  57

Phe Gln His Thr His Leu Pro Leu Thr 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  58

Gln Gln Trp Asn Ser Asn Pro Pro Thr 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  59

His Gln Tyr His Arg Ser Pro Arg Thr 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  60

Gln Gln Ser Lys Glu Val Pro Phe Thr 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  61

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  62

Gln Gln Gly His Thr Leu Pro Pro Thr 
1               5                   


<210>  63
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  63

Gln Gln His Ser Tyr Thr Pro Pro Trp Thr 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  64

Gln Gln His Ser Tyr Thr Pro Pro Trp Thr 
1               5                   10  


<210>  65
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  65

Gln Gln Tyr His Gly Phe Pro Asn Thr 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  66

Gln Gln Tyr His Gly Phe Pro Asn Thr 
1               5                   


<210>  67
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Can be A or F

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  Can be F or L

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  Can be R or K

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  Can be N or T

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Can be L or V

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  Can be A or V

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Xaa Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Xaa Thr Ile Ser Xaa Asp Xaa Ser Lys Asn Thr Xaa 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Xaa Arg Ser Tyr Tyr Tyr Gly Ser Ser Gly Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  68
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  69
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  Can be A or T

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  Can be R or T

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile His Ala Asn Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Xaa Xaa Gly Ser Phe Met Tyr Ala Ala Asp Tyr Tyr Ile Met Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  70
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  70

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Asn Thr Phe Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln His 
                85                  90                  95      


Thr His Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  71
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be M or I

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  Can be V or A

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  Can be M or F

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Can be T or A

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Xaa Thr Xaa Thr Xaa Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Val Tyr Tyr Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  72
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be L or W

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Can be F or Y

<400>  72

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Xaa 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  73
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Can be V or F

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Can be I or L

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  Can be G or A

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  Can be V or L

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be I or V

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  Can be V or K

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Can be F or A

<220>
<221>  VARIANT
<222>  (99)..(99)
<223>  Can be R or Q

<400>  73

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Xaa Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Xaa Xaa Asn Ile Trp Trp Asp Asp Asp Asn Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Ile His Arg Xaa Thr Xaa Ser Xaa Asp Thr Ser Lys Asn Gln Xaa 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Xaa Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Can be L or P

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Can be Y or F

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be F or Y

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asn Asn Phe 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Xaa Leu Ile 
        35                  40                  45              


Xaa Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Gly Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  75
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Can be V or F

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Can be I or L

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  Can be G or A

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  Can be V or L

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  Can be V or K

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Can be F or A

<220>
<221>  VARIANT
<222>  (99)..(99)
<223>  Can be R or Q

<400>  75

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Xaa Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Xaa Xaa Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Xaa Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Xaa 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Xaa Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Can be L or P

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Can be Y or F

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be F or Y

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asn Asn Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Xaa Leu Ile 
        35                  40                  45              


Xaa Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Gly Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  77
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (96)..(96)
<223>  Can be A or Q

<400>  77

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Arg Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Asp Arg Ser Tyr Leu Pro Asp Ser Met Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Xaa 
                85                  90                  95      


Arg Tyr Phe Asp Phe Asp Ser Phe Ala Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  78
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Can be W or Y

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be I or M

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be V or R

<220>
<221>  VARIANT
<222>  (96)..(96)
<223>  Can be A or S

<400>  79

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Xaa Xaa 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Xaa 
                85                  90                  95      


Arg Arg His Leu Gly Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be F or Y

<400>  80

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Ser Tyr Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  81
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  81

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Gly Tyr Tyr Asp Ser Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  82
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Can be N or Q

<220>
<221>  VARIANT
<222>  (57)..(57)
<223>  Can be N or Q

<400>  82

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Xaa Tyr 
            20                  25                  30          


Gly Val Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Xaa Gln Gly Ser Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  83
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Can be W or Y

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be I or M

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  Can be V or I

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be V or R

<220>
<221>  VARIANT
<222>  (78)..(78)
<223>  Can be F or Y

<220>
<221>  VARIANT
<222>  (96)..(96)
<223>  Can be A or S

<400>  83

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Xaa Xaa 
        35                  40                  45              


Gly Phe Ile Ser Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Xaa Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Xaa Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Xaa 
                85                  90                  95      


Arg Arg His Leu Ile Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  84
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Can be D or V

<400>  84

Xaa Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asp Val Ile Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Ser Tyr Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  85
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be M or I

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  Can be V or A

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  Can be M or L

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Can be T or A

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  Can be T or K

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Val Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Xaa Thr Xaa Thr Xaa Asp Xaa Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Tyr Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  86
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  87
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Can be I or M

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  Can be V or I

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Can be V or R

<400>  87

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Xaa Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Xaa Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Gly Leu Arg Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  88
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (45)..(45)
<223>  Can be L or P

<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Can be L or C

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Asn Ser Thr Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Xaa Xaa Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


