                         SEQUENCE LISTING

<110>  MacroGenics, Inc.
       Bonvini, Ezio
       Johnson, Leslie
       Huang, Ling
       Moore, Paul
       Chichili, Gurunadh
       Alderson, Ralph
 
<120>  Bi-Specific Monovalent Diabodies That Are Capable Of Binding 
       CD123 And CD3, And Uses Thereof

<130>  1301.0109PCT

<150>  US 61/907,749
<151>  2013-11-22

<150>  US 61/869,510
<151>  2013-08-23

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of DART-A

<400>  1

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Thr Phe Thr Asp Tyr Tyr Met Lys Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr 
                165                 170                 175     


Phe Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg Ser His Leu Leu Arg Ala Ser Trp 
    210                 215                 220                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
225                 230                 235                 240 


Cys Gly Gly Gly Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu 
                245                 250                 255     


Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            260                 265                 270         


<210>  2
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Molecule Encoding First Polypeptide Chain of DART-A

<400>  2
caggctgtgg tgactcagga gccttcactg accgtgtccc caggcggaac tgtgaccctg       60

acatgcagat ccagcacagg cgcagtgacc acatctaact acgccaattg ggtgcagcag      120

aagccaggac aggcaccaag gggcctgatc gggggtacaa acaaaagggc tccctggacc      180

cctgcacggt tttctggaag tctgctgggc ggaaaggccg ctctgactat taccggggca      240

caggccgagg acgaagccga ttactattgt gctctgtggt atagcaatct gtgggtgttc      300

gggggtggca caaaactgac tgtgctggga gggggtggat ccggcggcgg aggcgaggtg      360

cagctggtgc agtccggggc tgagctgaag aaacccggag cttccgtgaa ggtgtcttgc      420

aaagccagtg gctacacctt cacagactac tatatgaagt gggtcaggca ggctccagga      480

cagggactgg aatggatcgg cgatatcatt ccttccaacg gggccacttt ctacaatcag      540

aagtttaaag gcagggtgac tattaccgtg gacaaatcaa caagcactgc ttatatggag      600

ctgagctccc tgcgctctga agatacagcc gtgtactatt gtgctcggtc acacctgctg      660

agagccagct ggtttgctta ttggggacag ggcaccctgg tgacagtgtc ttccggagga      720

tgtggcggtg gagaagtggc cgcactggag aaagaggttg ctgctttgga gaaggaggtc      780

gctgcacttg aaaaggaggt cgcagccctg gagaaa                                816


<210>  3
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of DART-A

<400>  3

Asp Phe Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Thr Tyr Ala Met Asn Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Ser Lys Tyr 
                165                 170                 175     


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
    210                 215                 220                 


Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Cys Gly Gly Gly Lys Val Ala Ala 
                245                 250                 255     


Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys 
            260                 265                 270         


Glu Lys Val Ala Ala Leu Lys Glu 
        275                 280 


<210>  4
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Molecule Encoding Second Polypeptide Chain of DART-A

<400>  4
gacttcgtga tgacacagtc tcctgatagt ctggccgtga gtctggggga gcgggtgact       60

atgtcttgca agagctccca gtcactgctg aacagcggaa atcagaaaaa ctatctgacc      120

tggtaccagc agaagccagg ccagccccct aaactgctga tctattgggc ttccaccagg      180

gaatctggcg tgcccgacag attcagcggc agcggcagcg gcacagattt taccctgaca      240

atttctagtc tgcaggccga ggacgtggct gtgtactatt gtcagaatga ttacagctat      300

ccctacactt tcggccaggg gaccaagctg gaaattaaag gaggcggatc cggcggcgga      360

ggcgaggtgc agctggtgga gtctggggga ggcttggtcc agcctggagg gtccctgaga      420

ctctcctgtg cagcctctgg attcaccttc agcacatacg ctatgaattg ggtccgccag      480

gctccaggga aggggctgga gtgggttgga aggatcaggt ccaagtacaa caattatgca      540

acctactatg ccgactctgt gaaggataga ttcaccatct caagagatga ttcaaagaac      600

tcactgtatc tgcaaatgaa cagcctgaaa accgaggaca cggccgtgta ttactgtgtg      660

agacacggta acttcggcaa ttcttacgtg tcttggtttg cttattgggg acaggggaca      720

ctggtgactg tgtcttccgg aggatgtggc ggtggaaaag tggccgcact gaaggagaaa      780

gttgctgctt tgaaagagaa ggtcgccgca cttaaggaaa aggtcgcagc cctgaaagag      840


<210>  5
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of DART-B

<400>  5

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro 
        115                 120                 125             


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
    130                 135                 140                 


Asp Tyr Tyr Met Lys Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
145                 150                 155                 160 


Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln 
                165                 170                 175     


Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr 
            180                 185                 190         


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
        195                 200                 205             


Tyr Cys Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys Gly Gly Gly 
225                 230                 235                 240 


Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
                245                 250                 255     


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            260                 265             


<210>  6
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Molecule Encoding First Polypeptide Chain of DART-B

<400>  6
gacattcagc tgacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gagccagttc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaagtgg cttctggagt cccttatcgc      180

ttcagtggca gtgggtctgg gacctcatac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccaacagtgg agtagtaacc cgctcacgtt cggtgctggg      300

accaagctgg agctgaaagg aggcggatcc ggcggcggag gccaggtgca gctggtgcag      360

tccggggctg agctgaagaa acccggagct tccgtgaagg tgtcttgcaa agccagtggc      420

tacaccttca cagactacta tatgaagtgg gtcaggcagg ctccaggaca gggactggaa      480

tggatcggcg atatcattcc ttccaacggg gccactttct acaatcagaa gtttaaaggc      540

agggtgacta ttaccgtgga caaatcaaca agcactgctt atatggagct gagctccctg      600

cgctctgaag atacagccgt gtactattgt gctcggtcac acctgctgag agccagctgg      660

tttgcttatt ggggacaggg caccctggtg acagtgtctt ccggaggatg tggcggtgga      720

gaagtggccg cactggagaa agaggttgct gctttggaga aggaggtcgc tgcacttgaa      780

aaggaggtcg cagccctgga gaaa                                             804


<210>  7
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of DART-B

<400>  7

Asp Phe Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Lys Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                165                 170                 175     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    210                 215                 220                 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Cys Gly Gly Gly Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
                245                 250                 255     


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu 
            260                 265                 270         


Lys Glu 
        


<210>  8
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Molecule Encoding Second Polypeptide Chain of DART-B

<400>  8
gacttcgtga tgacacagtc tcctgatagt ctggccgtga gtctggggga gcgggtgact       60

atgtcttgca agagctccca gtcactgctg aacagcggaa atcagaaaaa ctatctgacc      120

tggtaccagc agaagccagg ccagccccct aaactgctga tctattgggc ttccaccagg      180

gaatctggcg tgcccgacag attcagcggc agcggcagcg gcacagattt taccctgaca      240

atttctagtc tgcaggccga ggacgtggct gtgtactatt gtcagaatga ttacagctat      300

ccctacactt tcggccaggg gaccaagctg gaaattaaag gaggcggatc cggcggcgga      360

ggcgatatca aactgcagca gtcaggggct gaactggcaa gacctggggc ctcagtgaag      420

atgtcctgca agacttctgg ctacaccttt actaggtaca cgatgcactg ggtaaaacag      480

aggcctggac agggtctgga atggattgga tacattaatc ctagccgtgg ttatactaat      540

tacaatcaga agttcaagga caaggccaca ttgactacag acaaatcctc cagcacagcc      600

tacatgcaac tgagcagcct gacatctgag gactctgcag tctattactg tgcaagatat      660

tatgatgatc attactgcct tgactactgg ggccaaggca ccactctcac agtctcctcc      720

ggaggatgtg gcggtggaaa agtggccgca ctgaaggaga aagttgctgc tttgaaagag      780

aaggtcgccg cacttaagga aaaggtcgca gccctgaaag ag                         822


<210>  9
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 x CD3 Diabody Polypeptide Chain Having Albumin Binding Site

<400>  9

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Thr Phe Thr Asp Tyr Tyr Met Lys Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr 
                165                 170                 175     


Phe Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg Ser His Leu Leu Arg Ala Ser Trp 
    210                 215                 220                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
225                 230                 235                 240 


Cys Gly Gly Gly Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu 
                245                 250                 255     


Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            260                 265                 270         


Gly Gly Gly Ser Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu 
        275                 280                 285             


Asp Lys Tyr Gly Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asp Asn Ala 
    290                 295                 300                 


Lys Ser Ala Glu Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala 
305                 310                 315                 320 


Leu Pro 
        


<210>  10
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding CD123 x CD3 Diabody Polypeptide Chain 
       Having Albumin Binding Site

<400>  10
caggctgtgg tgactcagga gccttcactg accgtgtccc caggcggaac tgtgaccctg       60

acatgcagat ccagcacagg cgcagtgacc acatctaact acgccaattg ggtgcagcag      120

aagccaggac aggcaccaag gggcctgatc gggggtacaa acaaaagggc tccctggacc      180

cctgcacggt tttctggaag tctgctgggc ggaaaggccg ctctgactat taccggggca      240

caggccgagg acgaagccga ttactattgt gctctgtggt atagcaatct gtgggtgttc      300

gggggtggca caaaactgac tgtgctggga gggggtggat ccggcggcgg aggcgaggtg      360

cagctggtgc agtccggggc tgagctgaag aaacccggag cttccgtgaa ggtgtcttgc      420

aaagccagtg gctacacctt cacagactac tatatgaagt gggtcaggca ggctccagga      480

cagggactgg aatggatcgg cgatatcatt ccttccaacg gggccacttt ctacaatcag      540

aagtttaaag gcagggtgac tattaccgtg gacaaatcaa caagcactgc ttatatggag      600

ctgagctccc tgcgctctga agatacagcc gtgtactatt gtgctcggtc acacctgctg      660

agagccagct ggtttgctta ttggggacag ggcaccctgg tgacagtgtc ttccggagga      720

tgtggcggtg gagaagtggc cgcactggag aaagaggttg ctgctttgga gaaggaggtc      780

gctgcacttg aaaaggaggt cgcagccctg gagaaaggcg gcgggtctct ggccgaagca      840

aaagtgctgg ccaaccgcga actggataaa tatggcgtga gcgattatta taagaacctg      900

attgacaacg caaaatccgc ggaaggcgtg aaagcactga ttgatgaaat tctggccgcc      960

ctgcct                                                                 966


<210>  11
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH2-CH3 Domains of a Modified Human Antibody Fc Region

<400>  11

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  12
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Molecule Encoding Peptide 1 and the CH2 and CH3 
       Domains of an IgG Fc region

<400>  12
gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgagttg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accgctacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  13
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of DART-A w/Fc Version 1 Construct

<400>  13

Asp Phe Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Thr Tyr Ala Met Asn Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Ser Lys Tyr 
                165                 170                 175     


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
    210                 215                 220                 


Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Cys Gly Gly Gly Glu Val Ala Ala 
                245                 250                 255     


Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu 
            260                 265                 270         


Lys Glu Val Ala Ala Leu Glu Lys Gly Gly Gly Asp Lys Thr His Thr 
        275                 280                 285             


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
    290                 295                 300                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
305                 310                 315                 320 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                325                 330                 335     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            340                 345                 350         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        355                 360                 365             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    370                 375                 380                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
385                 390                 395                 400 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                405                 410                 415     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
            420                 425                 430         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        435                 440                 445             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    450                 455                 460                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
465                 470                 475                 480 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                485                 490                 495     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505                 510 


<210>  14
<211>  1530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Molecule Encoding First Polypeptide Chain of DART-A 
       w/Fc Version 1 Construct

<400>  14
gacttcgtga tgacacagtc tcctgatagt ctggccgtga gtctggggga gcgggtgact       60

atgtcttgca agagctccca gtcactgctg aacagcggaa atcagaaaaa ctatctgacc      120

tggtaccagc agaagccagg ccagccccct aaactgctga tctattgggc ttccaccagg      180

gaatctggcg tgcccgacag attcagcggc agcggcagcg gcacagattt taccctgaca      240

atttctagtc tgcaggccga ggacgtggct gtgtactatt gtcagaatga ttacagctat      300

ccctacactt tcggccaggg gaccaagctg gaaattaaag gaggcggatc cggcggcgga      360

ggcgaggtgc agctggtgga gtctggggga ggcttggtcc agcctggagg gtccctgaga      420

ctctcctgtg cagcctctgg attcaccttc agcacatacg ctatgaattg ggtccgccag      480

gctccaggga aggggctgga gtgggttgga aggatcaggt ccaagtacaa caattatgca      540

acctactatg ccgactctgt gaaggataga ttcaccatct caagagatga ttcaaagaac      600

tcactgtatc tgcaaatgaa cagcctgaaa accgaggaca cggccgtgta ttactgtgtg      660

agacacggta acttcggcaa ttcttacgtg tcttggtttg cttattgggg acaggggaca      720

ctggtgactg tgtcttccgg aggatgtggc ggtggagaag tggccgcact ggagaaagag      780

gttgctgctt tggagaagga ggtcgctgca cttgaaaagg aggtcgcagc cctggagaaa      840

ggcggcgggg acaaaactca cacatgccca ccgtgcccag cacctgaagc cgcgggggga      900

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      960

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1020

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1080

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1140

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1200

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1260

atgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1320

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1380

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1440

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1500

cagaagagcc tctccctgtc tccgggtaaa                                      1530


<210>  15
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of DART-A w/Fc Version 1 Construct

<400>  15

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Thr Phe Thr Asp Tyr Tyr Met Lys Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr 
                165                 170                 175     


Phe Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg Ser His Leu Leu Arg Ala Ser Trp 
    210                 215                 220                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
225                 230                 235                 240 


Cys Gly Gly Gly Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu 
                245                 250                 255     


Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265                 270         


<210>  16
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Molecule Encoding Second Polypeptide Chain of DART-A
       w/Fc Version 1 Construct

<400>  16
caggctgtgg tgactcagga gccttcactg accgtgtccc caggcggaac tgtgaccctg       60

acatgcagat ccagcacagg cgcagtgacc acatctaact acgccaattg ggtgcagcag      120

aagccaggac aggcaccaag gggcctgatc gggggtacaa acaaaagggc tccctggacc      180

cctgcacggt tttctggaag tctgctgggc ggaaaggccg ctctgactat taccggggca      240

caggccgagg acgaagccga ttactattgt gctctgtggt atagcaatct gtgggtgttc      300

gggggtggca caaaactgac tgtgctggga gggggtggat ccggcggcgg aggcgaggtg      360

cagctggtgc agtccggggc tgagctgaag aaacccggag cttccgtgaa ggtgtcttgc      420

aaagccagtg gctacacctt cacagactac tatatgaagt gggtcaggca ggctccagga      480

cagggactgg aatggatcgg cgatatcatt ccttccaacg gggccacttt ctacaatcag      540

aagtttaaag gcagggtgac tattaccgtg gacaaatcaa caagcactgc ttatatggag      600

ctgagctccc tgcgctctga agatacagcc gtgtactatt gtgctcggtc acacctgctg      660

agagccagct ggtttgctta ttggggacag ggcaccctgg tgacagtgtc ttccggagga      720

tgtggcggtg gaaaagtggc cgcactgaag gagaaagttg ctgctttgaa agagaaggtc      780

gccgcactta aggaaaaggt cgcagccctg aaagag                                816


<210>  17
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of DART-A w/Fc Version 2 Construct

<400>  17

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Ala Pro Ser Ser Ser Pro Met Glu Asp Phe Val Met Thr 
225                 230                 235                 240 


Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Val Thr Met 
                245                 250                 255     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn 
            260                 265                 270         


Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
305                 310                 315                 320 


Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro 
                325                 330                 335     


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        355                 360                 365             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    370                 375                 380                 


Phe Ser Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
385                 390                 395                 400 


Leu Glu Trp Val Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                405                 410                 415     


Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
            420                 425                 430         


Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 
        435                 440                 445             


Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
    450                 455                 460                 


Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
465                 470                 475                 480 


Ser Gly Gly Cys Gly Gly Gly Lys Val Ala Ala Leu Lys Glu Lys Val 
                485                 490                 495     


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala 
            500                 505                 510         


Leu Lys Glu 
        515 


<210>  18
<211>  1545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Molecule Encoding First Polypeptide Chain of DART-A 
       w/Fc Version 2 Construct

<400>  18
gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa agccccttcc agctccccta tggaagactt cgtgatgaca      720

cagtctcctg atagtctggc cgtgagtctg ggggagcggg tgactatgtc ttgcaagagc      780

tcccagtcac tgctgaacag cggaaatcag aaaaactatc tgacctggta ccagcagaag      840

ccaggccagc cccctaaact gctgatctat tgggcttcca ccagggaatc tggcgtgccc      900

gacagattca gcggcagcgg cagcggcaca gattttaccc tgacaatttc tagtctgcag      960

gccgaggacg tggctgtgta ctattgtcag aatgattaca gctatcccta cactttcggc     1020

caggggacca agctggaaat taaaggaggc ggatccggcg gcggaggcga ggtgcagctg     1080

gtggagtctg ggggaggctt ggtccagcct ggagggtccc tgagactctc ctgtgcagcc     1140

tctggattca ccttcagcac atacgctatg aattgggtcc gccaggctcc agggaagggg     1200

ctggagtggg ttggaaggat caggtccaag tacaacaatt atgcaaccta ctatgccgac     1260

tctgtgaagg atagattcac catctcaaga gatgattcaa agaactcact gtatctgcaa     1320

atgaacagcc tgaaaaccga ggacacggcc gtgtattact gtgtgagaca cggtaacttc     1380

ggcaattctt acgtgtcttg gtttgcttat tggggacagg ggacactggt gactgtgtct     1440

tccggaggat gtggcggtgg aaaagtggcc gcactgaagg agaaagttgc tgctttgaaa     1500

gagaaggtcg ccgcacttaa ggaaaaggtc gcagccctga aagag                     1545


<210>  19
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of Control DART

<400>  19

Asp Val Val Met Thr Gln Thr Pro Phe Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
                165                 170                 175     


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
    210                 215                 220                 


Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Cys Gly Gly Gly Glu Val Ala Ala Leu 
                245                 250                 255     


Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            260                 265                 270         


Glu Val Ala Ala Leu Glu Lys 
        275                 


<210>  20
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of Control DART

<400>  20

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Lys Leu Asp Glu Thr Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Arg Pro Met Lys Leu Ser Cys Val Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Ser Asp Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Gln Ile Arg Asn Lys Pro Tyr Asn Tyr 
                165                 170                 175     


Glu Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Val 
        195                 200                 205             


Glu Asp Met Gly Ile Tyr Tyr Cys Thr Gly Ser Tyr Tyr Gly Met Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Cys Gly 
225                 230                 235                 240 


Gly Gly Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
                245                 250                 255     


Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265                 270 


<210>  21
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CD3-Binding Domain of DART-A

<400>  21

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  22
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CD3-Binding Domain of DART-A

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  23
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CD3-Binding Domain of DART-B

<400>  23

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  24
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CD3-Binding Domain of DART-B

<400>  24

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  25
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CD123-Binding Domain of DART-A

<400>  25

Asp Phe Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  26
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CD123-Binding Domain of DART-A

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CD123-Binding Domain of DART-B

<400>  27

Asp Phe Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  28
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CD123-Binding Domain of DART-B

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1 Polypeptide

<400>  29

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2 Polypeptide

<400>  30

Gly Gly Cys Gly Gly Gly 
1               5       


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 Polypetide

<400>  31

Gly Gly Gly Ser 
1               


<210>  32

<400>  32
000

<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 4 Polypeptide

<400>  33

Ala Pro Ser Ser Ser Pro Met Glu 
1               5               


<210>  34
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-Coil Domain

<400>  34

Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            20                  25              


<210>  35
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K-Coil Domain

<400>  35

Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            20                  25              


<210>  36
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Albumin Binding Domain

<400>  36

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asp Asn Ala Lys Ser Ala Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  37
<211>  217
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(217)
<223>  CH2-CH3 Domains of Human Fc Region

<400>  37

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  38
<211>  14
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR1 of Light Chain Variable Domain of Anti-CD3 Antibody

<400>  38

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  39
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR2 of Light Chain Variable Domain of Anti-CD3 Antibody

<400>  39

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  CDR3 of Light Chain Variable Domain of Anti-CD3 Antibody

<400>  40

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  41
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 of Heavy Chain Variable Domain of Anti-CD3 Antibody

<400>  41

Thr Tyr Ala Met Asn 
1               5   


<210>  42
<211>  19
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  CDR2 of Heavy Chain Variable Domain of Anti-CD3 Antibody

<400>  42

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  43
<211>  14
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 of Heavy Chain Variable Domain of Anti-CD3 Antibody

<400>  43

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  44
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR1 of Light Chain Variable Domain of Anti-CD123 Antibody

<400>  44

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  45
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR2 of Light Chain Variable Domain of Anti-CD123 Antibody

<400>  45

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  CDR3 of Light Chain Variable Domain of Anti-CD123 Antibody

<400>  46

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  47
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 of Heavy Chain Variable Domain of Anti-CD123 Antibody

<400>  47

Asp Tyr Tyr Met Lys 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 of Heavy Chain Variable Domain of Anti-CD123 Antibody

<400>  48

Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR3 of Heavy Chain Variable Domain of Anti-CD123 Antibody

<400>  49

Ser His Leu Leu Arg Ala Ser 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterodimerization Domain

<400>  50

Gly Val Glu Pro Lys Ser Cys 
1               5           


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterodimerization Domain

<400>  51

Val Glu Pro Lys Ser Cys 
1               5       


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterodimerization Domain

<400>  52

Gly Phe Asn Arg Gly Glu Cys 
1               5           


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterodimerization Domain

<400>  53

Phe Asn Arg Gly Glu Cys 
1               5       


<210>  54
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third Polypeptide Chain of DART-A w/Fc Version 1 Construct

<400>  54

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 1

<400>  55

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  56
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred CH2 and CH3 Domains of Fc Region

<400>  56

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 4 Polypeptide

<400>  57

Ala Pro Ser Ser Ser 
1               5   


<210>  58
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of First Polypeptide Chain of "Control 
       DART-2"

<400>  58

Asp Phe Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Lys Leu Asp Glu Thr 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Arg Pro Met Lys Leu Ser Cys Val 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Asp Tyr Trp Met Asn Trp Val Arg Gln 
145                 150                 155                 160 


Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln Ile Arg Asn Lys Pro 
                165                 170                 175     


Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn 
        195                 200                 205             


Leu Arg Val Glu Asp Met Gly Ile Tyr Tyr Cys Thr Gly Ser Tyr Tyr 
    210                 215                 220                 


Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
225                 230                 235                 240 


Gly Cys Gly Gly Gly Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala 
                245                 250                 255     


Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu 
            260                 265                 270         


Lys 
    


<210>  59
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Second Polypeptide Chain of "Control 
       DART-2"

<400>  59

Asp Val Val Met Thr Gln Thr Pro Phe Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly 
        115                 120                 125             


Ala Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
    130                 135                 140                 


Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Lys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly 
                165                 170                 175     


Ala Thr Phe Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val 
            180                 185                 190         


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser His Leu Leu Arg Ala 
    210                 215                 220                 


Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Cys Gly Gly Gly Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
                245                 250                 255     


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu 
            260                 265                 270         


Lys Glu 
        


