                         SEQUENCE LISTING

<110>  The Research Foundation Of State University Of New York At 
       Albany
       Conklin, Douglas  S.
       Eifert, Cheryl
       Kourtidis, Antonis
       Wang, Xianhui
       Kokabee, Leila
 
<120>  Bruton's Tyrosine Kinase as Anti-Cancer Drug Target

<130>  SUNYALB-17865

<140>  PCT/US14/51875
<141>  2014-08-20

<150>  US 13/971,662
<151>  2013-08-20

<150>  US 14/220,972
<151>  2014-03-20

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  1
actcaagata gtagtgtcag aggtcccaac caaatgaagg gcggggacag ttgagggggt       60

ggaataggga cggcagcagg gaaccagata gcatgctgct gagaagaaaa aaagacattg      120

gtttaggtca ggaaccaaaa aaagggaact gagtggctgt gaaagggtgg ggtttgctca      180

gactgtcctt cctctctgga ctgtaagaat atgtctccag ggccagtgtc tgctgcgatc      240

gagtcccacc ttccaagtcc tggcatctca atgcatctgg gaagctacct gcattaagtc      300

aggactgagc acacaggtga actccagaaa gaagaagcta tggccgcagt gattctggag      360

agcatctttc tgaagcgatc ccaacagaaa aagaaa                                396


<210>  2
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  2
ctttatctct tttggtggac tctgctacgt agtggcgttc agtgaaggga gcagtgtttt       60

tcccagatcc tctggcctcc ccgtccccga gggaagccag gactagggtc gaatgaaggg      120

gtcctccacc tccacgttcc attcctgttc cacctcaagg tcactgggaa cacctttcgc      180

agcaaactgc taattcaatg aagacctgga gggagccaat tgttccagtt catctatcac      240

atggccagtt ggtccattca acaaatggtt attggatgcc cattatgtgg caggcactgt      300

tccgggggag agcacacagg tgaactccag aaagaagaag ctatggccgc agtgattctg      360

gagagcatct ttctgaagcg atcccaacag aaaaagaaa                             399


<210>  3
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ser Trp Ser Ile Gln Gln Met Val Ile Gly Cys Pro Leu Cys 
1               5                   10                  15      


Gly Arg His Cys Ser Gly Gly Glu His Thr Gly Glu Leu Gln Lys Glu 
            20                  25                  30          


Glu Ala Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser 
        35                  40                  45              


Gln Gln Lys Lys Lys 
    50              


<210>  4
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  4
tgaactccag aaagaagaag ctatg                                             25


<210>  5
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  5
cctcccctcc catctttatg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  6
cgtcttctcc ccaactgaag                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  7
tttgaaagtg ggacgctcat                                                   20


<210>  8
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  8
tgctgcgatc gagtcccac                                                    19


<210>  9
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  9
tttgaaagtg ggacgctcat                                                   20


<210>  10
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  10
aaatggttat tggatgccca tt                                                22


<210>  11
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  11
tttgaaagtg ggacgctcat                                                   20


<210>  12
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  12
aaatggttat tggatgccca tt                                                22


<210>  13
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  13
tcttctttct ggagttcacc tgtct                                             25


<210>  14
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  14
tccttcctct ctggactgta agaatat                                           27


<210>  15
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  15
acttggaagg tgggactcga t                                                 21


<210>  16
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  16
tctccagggc cagtgtctgc tgc                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  17
tcttttggtg gactctgcta cgt                                               23


<210>  18
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  18
ggccagagga tctgggaaa                                                    19


<210>  19
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  19
tggcgttcag tgaagggagc agtgt                                             25


<210>  20
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  20
gtgaaccgtc agatccgcta                                                   20


<210>  21
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  21
aggtacgggc ccctatttat cgtcatcatc tttgt                                  35


<210>  22
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  22
aaagaacaat tgatggccgc agtgattctg gag                                    33


<210>  23
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  23
cttatctcga gggattcttc atccatgaca tc                                     32


<210>  24
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  24
agagtggatc cgccaccctt tatctctttt ggtggactc                              39


<210>  25
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  25
ccagaatcac tgcggccat                                                    19


<210>  26
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  26
atggccgcag tgattctgg                                                    19


<210>  27
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  27
cttatctcga gggattcttc atccatgaca tc                                     32


<210>  28
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  28
agagtggatc cgccaccctt tatctctttt ggtggactc                              39


<210>  29
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  29
cttatctcga gggattcttc atccatgaca tc                                     32


<210>  30
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  30
gagctggtga atccaccgct tccttagttc ttc                                    33


<210>  31
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  31
cgactggagc acgaggacac tga                                               23


<210>  32
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  32
agttggggag aagacgtaga gaggcccttc at                                     32


<210>  33
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  33
ggacactgac atggactgaa ggagta                                            26


<210>  34
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  34

Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly 
1               5                   10                  15      


Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly 
            20                  25                  30          


Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr 
        35                  40                  45              


Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala 
    50                  55                  60                  


Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr 
65                  70                  75                  80  


Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu 
                85                  90                  95      


Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu 
            100                 105                 110         


Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg 
        115                 120                 125             


Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr 
    130                 135                 140                 


Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly 
145                 150                 155                 160 


Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys 
                165                 170                 175     


Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser 
            180                 185                 190         


Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly 
        195                 200                 205             


Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu 
    210                 215                 220                 


Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val 
225                 230                 235                 240 


Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro 
                245                 250                 255     


Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro 
            260                 265                 270         


Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser 
        275                 280                 285             


Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met 
    290                 295                 300                 


Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro 
305                 310                 315     


<210>  35
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
1               5                   10                  15      


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            20                  25                  30          


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        35                  40                  45              


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    50                  55                  60                  


Leu Leu Gly Ile Cys Leu Thr Ser Ser Leu Gln Leu Val Thr Gln Tyr 
65                  70                  75                  80  


Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg Gln His Arg Gly Ala 
                85                  90                  95      


Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val Gln Ile Ala Lys Gly 
            100                 105                 110         


Met Tyr Tyr Leu Glu Glu His Gly Met Val His Arg Asn Leu Ala Ala 
        115                 120                 125             


Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val Gln Val Ala Asp Phe 
    130                 135                 140                 


Gly Val Ala Asp Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
145                 150                 155                 160 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                165                 170                 175     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            180                 185                 190         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        195                 200                 205             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    210                 215                 220                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met 
225                 230                 235                 240 


Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu Leu Ala Asn Glu Phe 
                245                 250                 255     


<210>  36
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe Gly Thr Val His Lys 
1               5                   10                  15      


Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys Ile Pro Val Cys Ile 
            20                  25                  30          


Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser Phe Gln Ala Val Thr 
        35                  40                  45              


Asp His Met Leu Ala Ile Gly Ser Leu Asp His Ala His Ile Val Arg 
    50                  55                  60                  


Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln Leu Val Thr Gln Tyr 
65                  70                  75                  80  


Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg Gln His Arg Gly Ala 
                85                  90                  95      


Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val Gln Ile Ala Lys Gly 
            100                 105                 110         


Met Tyr Tyr Leu Glu Glu His Gly Met Val His Arg Asn Leu Ala Ala 
        115                 120                 125             


Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val Gln Val Ala Asp Phe 
    130                 135                 140                 


Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys Gln Leu Leu Tyr Ser 
145                 150                 155                 160 


Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu Glu Ser Ile His Phe 
                165                 170                 175     


Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser Thr Gly Val Thr Val 
            180                 185                 190         


Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr Ala Gly Leu Arg Leu 
        195                 200                 205             


Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Ala Gln Pro 
    210                 215                 220                 


Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met 
225                 230                 235                 240 


Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu Leu Ala Asn Glu Phe 
                245                 250                 255     


<210>  37
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  37

Lys Arg Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
1               5                   10                  15      


Gly Ile Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile 
            20                  25                  30          


Lys Ile Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met 
        35                  40                  45              


Asp Glu Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg 
    50                  55                  60                  


Leu Leu Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu 
65                  70                  75                  80  


Met Pro His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn 
                85                  90                  95      


Ile Gly Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly 
            100                 105                 110         


Met Met Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala 
        115                 120                 125             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp 
145                 150                 155                 160 


Gly Gly Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr 
                165                 170                 175     


Arg Lys Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile 
            180                 185                 190         


Trp Glu Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr 
        195                 200                 205             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    210                 215                 220                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Val Met Val 
225                 230                 235     


<210>  38
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  38

Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val Lys Tyr 
1               5                   10                  15      


Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile Lys Glu 
            20                  25                  30          


Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val Met Met 
        35                  40                  45              


Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys Thr Lys 
    50                  55                  60                  


Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly Cys Leu 
65                  70                  75                  80  


Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln Gln Leu 
                85                  90                  95      


Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu Glu Ser 
            100                 105                 110         


Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Asn 
        115                 120                 125             


Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr Val 
    130                 135                 140                 


Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro Val Arg 
145                 150                 155                 160 


Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser Lys Ser 
                165                 170                 175     


Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser Leu Gly 
            180                 185                 190         


Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu His Ile 
        195                 200                 205             


Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu Lys Val 
    210                 215                 220                 


Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu Arg Pro 
225                 230                 235                 240 


Thr Phe Lys Ile Leu Leu Ser Asn Ile 
                245                 


<210>  39
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  39

Tyr Glu Ile Arg Trp Arg Val Ile Glu Ser Ile Ser Pro Asp Gly His 
1               5                   10                  15      


Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp 
            20                  25                  30          


Glu Phe Pro Arg Asp Gly Leu Val Leu Gly Arg Val Leu Gly Ser Gly 
        35                  40                  45              


Ala Phe Gly Lys Val Val Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser 
    50                  55                  60                  


Gln Pro Val Met Lys Val Ala Val Lys Met Leu Lys Pro Thr Ala Arg 
65                  70                  75                  80  


Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Thr His 
                85                  90                  95      


Leu Gly Pro His Leu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Lys 
            100                 105                 110         


Ser Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Phe Tyr Cys Asp Leu 
        115                 120                 125             


Val Asn Tyr Leu His Lys Asn Arg Asp Ser Phe Leu Ser His His Pro 
    130                 135                 140                 


Glu Lys Pro Lys Lys Glu Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp 
145                 150                 155                 160 


Glu Ser Thr Arg Ser Tyr Val Ile Leu Ser Phe Glu Asn Asn Gly Asp 
                165                 170                 175     


Tyr Met Asp Met Lys Gln Ala Asp Thr Thr Gln Tyr Val Pro Met Leu 
            180                 185                 190         


Glu Arg Lys Glu Val Ser Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr 
        195                 200                 205             


Asp Arg Pro Ala Ser Tyr Lys Lys Lys Ser Met Leu Asp Ser Glu Val 
    210                 215                 220                 


Lys Asn Leu Leu Ser Asp Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp 
225                 230                 235                 240 


Leu Leu Ser Phe Thr Tyr Gln Val Ala Arg Gly Met Glu Phe Leu Ala 
                245                 250                 255     


Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Leu 
            260                 265                 270         


Ala Gln Gly Lys Ile Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
        275                 280                 285             


Ile Met His Asp Ser Asn Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro 
    290                 295                 300                 


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr 
305                 310                 315                 320 


Leu Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser 
                325                 330                 335     


Leu Gly Gly Thr Pro Tyr Pro Gly Met Met Val Asp Ser Thr Phe Tyr 
            340                 345                 350         


Asn Lys Ile Lys Ser Gly Tyr Arg Met Ala Lys Pro Asp His Ala Thr 
        355                 360                 365             


Ser Glu Val Tyr Glu Ile Met Val Lys Cys Trp Asn Ser Glu Pro Glu 
    370                 375                 380                 


Lys Arg Pro Ser Phe Tyr His 
385                 390     


<210>  40
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
1               5                   10                  15      


Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr 
            20                  25                  30          


Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu 
        35                  40                  45              


Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    50                  55                  60                  


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
65                  70                  75                  80  


Tyr Val Ile Val Glu Tyr Ala Ser Lys Cys Asn Leu Arg Glu Tyr Leu 
                85                  90                  95      


Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His 
            100                 105                 110         


Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr 
        115                 120                 125             


Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His 
    130                 135                 140                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met 
145                 150                 155                 160 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr 
                165                 170                 175     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            180                 185                 190         


Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser 
        195                 200                 205             


Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    210                 215                 220                 


Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
225                 230                 235                 240 


Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                245                 250                 255     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            260                 265                 270         


Leu Val Glu 
        275 


<210>  41
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp 
1               5                   10                  15      


Met Gly Thr Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys 
            20                  25                  30          


Pro Gly Thr Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met 
        35                  40                  45              


Lys Lys Leu Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser 
    50                  55                  60                  


Glu Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu 
65                  70                  75                  80  


Leu Asp Phe Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln 
                85                  90                  95      


Leu Val Asp Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu 
            100                 105                 110         


Arg Met Asn Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        115                 120                 125             


Gly Glu Asn Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu 
    130                 135                 140                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile 
145                 150                 155                 160 


Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys 
                165                 170                 175     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys 
            180                 185                 190         


Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln 
        195                 200                 205             


Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser 
    210                 215                 220                 


Leu His Asp Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg 
225                 230                 235                 240 


Pro Thr Phe Glu Tyr Leu Gln Ala 
                245             


<210>  42
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Val Ile Gly Arg Gly His Phe Gly Cys Val Tyr His Gly Thr Leu 
1               5                   10                  15      


Leu Asp Asn Asp Gly Lys Lys Ile His Cys Ala Val Lys Ser Leu Asn 
            20                  25                  30          


Arg Ile Thr Asp Ile Gly Glu Val Ser Gln Phe Leu Thr Glu Gly Ile 
        35                  40                  45              


Ile Met Lys Asp Phe Ser His Pro Asn Val Leu Ser Leu Leu Gly Ile 
    50                  55                  60                  


Cys Leu Arg Ser Glu Gly Ser Pro Leu Val Val Leu Pro Tyr Met Lys 
65                  70                  75                  80  


His Gly Asp Leu Arg Asn Phe Ile Arg Asn Glu Thr His Asn Pro Thr 
                85                  90                  95      


Val Lys Asp Leu Ile Gly Phe Gly Leu Gln Val Ala Lys Gly Met Lys 
            100                 105                 110         


Tyr Leu Ala Ser Lys Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn 
        115                 120                 125             


Cys Met Leu Asp Glu Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu 
    130                 135                 140                 


Ala Arg Asp Met Tyr Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr 
145                 150                 155                 160 


Gly Ala Lys Leu Pro Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr 
                165                 170                 175     


Gln Lys Phe Thr Thr Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
            180                 185                 190         


Trp Glu Leu Met Thr Arg Gly Ala Pro Pro Tyr Pro Asp Val Asn Thr 
        195                 200                 205             


Phe Asp Ile Thr Val Tyr Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro 
    210                 215                 220                 


Glu Tyr Cys Pro Asp Pro Leu Tyr Glu Val Met Leu Lys Cys Trp His 
225                 230                 235                 240 


Pro Lys Ala Glu Met Arg Pro Ser Phe Ser Glu Leu Val Ser 
                245                 250                 


<210>  43
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  43

Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val Lys Tyr 
1               5                   10                  15      


Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile Lys Glu 
            20                  25                  30          


Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val Met Met 
        35                  40                  45              


Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys Thr Lys 
    50                  55                  60                  


Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly Cys Leu 
65                  70                  75                  80  


Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln Gln Leu 
                85                  90                  95      


Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu Glu Ser 
            100                 105                 110         


Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Asn 
        115                 120                 125             


Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr Val 
    130                 135                 140                 


Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro Val Arg 
145                 150                 155                 160 


Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser Lys Ser 
                165                 170                 175     


Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser Leu Gly 
            180                 185                 190         


Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu His Ile 
        195                 200                 205             


Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu Lys Val 
    210                 215                 220                 


Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu Arg Pro 
225                 230                 235                 240 


Thr Phe Lys Ile Leu Leu Ser 
                245         


<210>  44
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  44
ttatcttaat                                                              10


<210>  45
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  45
accaaattat gcggaatcca t                                                 21


<210>  46
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  46
tccatcttac cctgg                                                        15


<210>  47
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  47
tccggcgggt tttag                                                        15


<210>  48
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  48
gttttaggga cgttaaccta gta                                               23


<210>  49
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  49
taaagaaaca gttca                                                        15


<210>  50
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  50
aaacagttca gaacgtgcaa t                                                 21


<210>  51
<211>  13
<212>  DNA
<213>  Homo sapiens

<400>  51
tcctcattac ttg                                                          13


<210>  52
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  52
cctcattaac tc                                                           12


<210>  53
<211>  8
<212>  DNA
<213>  Homo sapiens

<400>  53
ccaccccc                                                                 8


<210>  54
<211>  13
<212>  DNA
<213>  Homo sapiens

<400>  54
tagcccggtc cct                                                          13


<210>  55
<211>  7
<212>  DNA
<213>  Homo sapiens

<400>  55
agattgg                                                                  7


<210>  56
<211>  8
<212>  DNA
<213>  Homo sapiens

<400>  56
ttgggttg                                                                 8


<210>  57
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  57
tatcgagtcc acacaggag                                                    19


<210>  58
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  58
gctggatgtt actcg                                                        15


<210>  59
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  59
catgcttgcg tgagc                                                        15


<210>  60
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  60
cttgcgtgag c                                                            11


<210>  61
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  61
gcaaacgga                                                                9


<210>  62
<211>  13
<212>  DNA
<213>  Homo sapiens

<400>  62
caaacggaag tat                                                          13


<210>  63
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  63
aacggaagta tatag                                                        15


<210>  64
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  64
cgccctcggg cg                                                           12


<210>  65
<211>  8
<212>  DNA
<213>  Homo sapiens

<400>  65
acttcctc                                                                 8


<210>  66
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  66
gguuauugga ugcccauuau u                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  67
uaaugggcau ccaauaaccu u                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  68
caacaaaugg uuauuggauu u                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  69
auccaauaac cauuuguugu u                                                 21


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Met Ala Asn Gly Cys Leu Leu 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Met Pro Phe Gly Cys Leu Leu 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Met Pro Tyr Gly Cys Leu Leu 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Leu Pro Leu Gly Ser Leu Leu 
1               5           


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Met Pro His Gly Cys Leu Leu 
1               5           


