                         SEQUENCE LISTING

<110>  Quintiles Transnational
 
<120>  METHODS FOR PREDICTING TOXICITY IN RESPONSE TO TREATMENT WITH A 
       DRUG BY ASSESSING ACTIVATION OF THE STEROL REGULATORY BINDING 
       PROTEIN (SREBP) PATHWAY

<130>  3714714.00116

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  4325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized: SREBP2 mRNA

<400>  1
gccctttctg tgcggcgccc gggcgcaacg caaacatggc ggcgggtggc acccgtcggt       60

gaggcggtgc cgggcggggg ttgtcgggtg tcatgggcgg tggcgacggc accgcccccg      120

cgtctccctg agcgggacgg cagggggggc ttctgcgctg agccgggcga tggacgacag      180

cggcgagctg ggtggtctgg agaccatgga gaccctcacg gagctgggcg acgagctgac      240

cctgggagac atcgacgaga tgctgcaatt tgtcagtaat caagtgggag agttccctga      300

cttgttttca gaacagctgt gtagctcctt tcctggcagt ggtggtagtg gtagcagcag      360

cggcagcagt ggcagcagca gcagcagcag caatggcagg ggcagcagca gcggagctgt      420

ggacccttca gtgcaacggt cattcaccca ggtcacatta ccttccttct ctccctcggc      480

ggcctcccca caggctccaa ctctgcaagt caaggtttct cccacctcag ttcccaccac      540

acccagggca actcctattc ttcagccccg cccccagccc cagcctcaac ctcaaactca      600

gctgcaacaa cagacggtaa tgatcacgcc aacattcagc accactccgc agacgaggat      660

catccagcag cctttgatat accagaatgc agctactagc tttcaagtcc ttcagcctca      720

agtccaaagc ctggtgacat cctcccaggt acagccggtc accattcagc agcaggtgca      780

gacagtacag gcccagcggg tgctgacaca aacggccaat ggcacgctgc agacccttgc      840

cccggctacg gtgcagacag ttgctgcgcc acaggtgcag caggtcccgg tcctggtcca      900

gcctcagatc atcaagacag attcccttgt tttgaccaca ctgaagacag atggcagccc      960

tgttatggct gcggtccaga acccggccct caccgccctc accaccccta tccagacggc     1020

tgcccttcaa gtaccaaccc tggtgggcag cagtgggacc attctgacca caatgcctgt     1080

aatgatgggg caagagaaag tgcccattaa gcaggtacct gggggagtca agcagcttga     1140

gccccccaaa gaaggagaaa ggcggacaac ccataatatc attgagaaac gatatcgctc     1200

ctccatcaat gacaaaatca tcgaattgaa agacctggtc atggggacag acgccaagat     1260

gcacaagtct ggcgttctga ggaaggccat tgattacatc aaatacttgc agcaggtcaa     1320

tcataaactg cgccaggaga acatggtgct gaagctggca aatcaaaaga acaagcttct     1380

aaagggcatc gacctaggca gtctggtgga caatgaggtg gacctgaaga tcgaggactt     1440

taatcagaat gtccttctga tgtccccccc agcctctgac tcagggtccc aggctggctt     1500

ctctccctac tccattgact ctgagccagg aagccctcta ttggatgatg caaaggtcaa     1560

agatgagcca gactctcctc ctgtggcgct gggcatggta gaccgctcac ggattcttct     1620

gtgtgtcctc accttcctgt gcctctcctt taaccccctg acttccctgc tgcagtgggg     1680

aggggcccac gactctgacc agcacccaca ctcaggctct ggccgcagtg tcctgtcatt     1740

cgagtcaggt tctgggggct ggtttgactg gatgatgcct actcttctct tatggctggt     1800

aaatggtgtg attgtcctga gcgtctttgt gaagctgctg gttcatgggg agccagtgat     1860

ccggccacac tcgcgctcct cggtcacctt ctggaggcac cggaaacagg cagatctgga     1920

tctcgccaga ggagattttg cagctgctgc cggcaaccta caaacctgcc tggcagtttt     1980

gggccgggca ctgcccacct cccgcctgga cctggcctgc agcctctcct ggaacgtgat     2040

ccgctacagc ctgcagaagc tacgcctggt gcgctggctg ctcaagaaag tcttccagtg     2100

ccggcgggcc acgccagcca ctgaggcagg ctttgaagac gaagctaaga ccagcgcccg     2160

ggatgcggct ctggcctatc accggctgca ccagctgcac atcacaggga agcttcctgc     2220

aggatccgcc tgttccgatg tacacatggc gttgtgtgcc gtgaacctgg ctgaatgtgc     2280

agaggagaag atcccaccga gcacactggt tgagatccat ctgactgctg ccatggggct     2340

caagacccgg tgtggaggca agctgggctt cctggccagc tacttcctca gccgagccca     2400

gagcctgtgt ggccccgagc acagtgctgt tcctgactcc ctgcgctggc tctgccaccc     2460

cctgggccag aagtttttca tggagcggag ctggtctgtg aagtcagctg ccaaggagag     2520

tctatactgt gcccagagga acccagctga ccccattgcg caggtccacc aggccttctg     2580

caagaacctg ctggagcgag ctatagagtc cttggtgaaa cctcaggcca agaagaaggc     2640

tggagaccag gaagaagaga gctgtgaatt ctccagtgct ctggagtact tgaaattact     2700

tcattctttt gtggactctg tgggggttat gagcccccca ctctccagga gctccgtgct     2760

caagtccgcc ctgggtccag acatcatctg tcggtggtgg acgtctgcaa tcactgtggc     2820

catcagctgg ctccagggag acgatgcagc tgtgcgctct cattttacca aagtggaacg     2880

catccccaag gccctggaag tgacagagag ccccctggtg aaggccatct tccatgcctg     2940

cagagccatg catgcctcac tccctgggaa agcagatggg cagcagagtt ccttctgcca     3000

ttgcgagagg gccagtggcc acctatggag cagcctcaac gtcagtgggg ccacctctga     3060

ccctgccctc aaccacgtgg tccagctgct cacctgtgac ctgctactgt cgctacggac     3120

agcgctctgg caaaaacagg ccagtgccag ccaggctgtg ggggagacct accacgcgtc     3180

aggcgctgaa ctggcgggct tccaacggga cctgggcagc ctgcgcaggc tggcacacag     3240

cttccgccca gcataccgca aggtgttcct gcatgaagcc accgtgcgcc tgatggcagg     3300

agccagcccc acccgcaccc accagctgct ggaacacagc ctgcggcggc gcaccacgca     3360

gagcaccaag cacggagagg tggatgcctg gcccggccag cgagagcggg ccaccgccat     3420

cctgctggcc tgccgccacc tgcccctctc cttcctctcc tccccgggcc agcgggcagt     3480

gctgctggcc gaagctgccc gcaccctgga gaaggtgggc gaccggcgct cctgcaacga     3540

ctgccagcag atgattgtta agctgggtgg tggcactgcc attgccgcct cctgaccacc     3600

aggctcagcc cacccctcca cctctctctc gatttctctc tctccccctc agcatcttcc     3660

cgctgagagt ggtggggaag agccttgtct tcttagctgt cacctgccga ggcttctggg     3720

ccactcaggc cagtgcaccc ctgggcagag ccccttaaag ctgctgtcac tagatgccca     3780

tggtccaggg cctggtgggc gtgagaggat aggtggcagg gcagaaactg ggcagccctg     3840

acttgatagc agcaggggga gctcccaagc tgccaagccc ctgcctccag ccttcctgag     3900

tttctctctc ctgaacccta ctctctcctt tttgcttcct cagtttttat caggctttct     3960

ctgggggaca gcagtctctg agcaccaggg agcagttgcc ctcaggcctg tgcccagcat     4020

gccctcccct ttttatacga atgttttcta ccagtgtgct tgggtttgcc atgatgcgag     4080

gctgagttgc tgtagcgtct tgattctctc cctgggtctg cgttccctcc cctgggcctg     4140

actgagcctg ctcattgttt ttccctttat tacacaggac agccagggga ggaggggggc     4200

ccagccctgg gaggctggtg ggaggcaggg ggcaggcctg cggatgcatg aaataatgtt     4260

ggcattattt tttaattttt taaaaaataa atggtatctt atttaaaaaa aaaaaaaaaa     4320

aaaaa                                                                 4325


<210>  2
<211>  1141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized: SREBP2 protein

<400>  2

Met Asp Asp Ser Gly Glu Leu Gly Gly Leu Glu Thr Met Glu Thr Leu 
1               5                   10                  15      


Thr Glu Leu Gly Asp Glu Leu Thr Leu Gly Asp Ile Asp Glu Met Leu 
            20                  25                  30          


Gln Phe Val Ser Asn Gln Val Gly Glu Phe Pro Asp Leu Phe Ser Glu 
        35                  40                  45              


Gln Leu Cys Ser Ser Phe Pro Gly Ser Gly Gly Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Ser Ser Gly Ser Ser Ser Ser Ser Ser Asn Gly Arg Gly Ser Ser 
65                  70                  75                  80  


Ser Gly Ala Val Asp Pro Ser Val Gln Arg Ser Phe Thr Gln Val Thr 
                85                  90                  95      


Leu Pro Ser Phe Ser Pro Ser Ala Ala Ser Pro Gln Ala Pro Thr Leu 
            100                 105                 110         


Gln Val Lys Val Ser Pro Thr Ser Val Pro Thr Thr Pro Arg Ala Thr 
        115                 120                 125             


Pro Ile Leu Gln Pro Arg Pro Gln Pro Gln Pro Gln Pro Gln Thr Gln 
    130                 135                 140                 


Leu Gln Gln Gln Thr Val Met Ile Thr Pro Thr Phe Ser Thr Thr Pro 
145                 150                 155                 160 


Gln Thr Arg Ile Ile Gln Gln Pro Leu Ile Tyr Gln Asn Ala Ala Thr 
                165                 170                 175     


Ser Phe Gln Val Leu Gln Pro Gln Val Gln Ser Leu Val Thr Ser Ser 
            180                 185                 190         


Gln Val Gln Pro Val Thr Ile Gln Gln Gln Val Gln Thr Val Gln Ala 
        195                 200                 205             


Gln Arg Val Leu Thr Gln Thr Ala Asn Gly Thr Leu Gln Thr Leu Ala 
    210                 215                 220                 


Pro Ala Thr Val Gln Thr Val Ala Ala Pro Gln Val Gln Gln Val Pro 
225                 230                 235                 240 


Val Leu Val Gln Pro Gln Ile Ile Lys Thr Asp Ser Leu Val Leu Thr 
                245                 250                 255     


Thr Leu Lys Thr Asp Gly Ser Pro Val Met Ala Ala Val Gln Asn Pro 
            260                 265                 270         


Ala Leu Thr Ala Leu Thr Thr Pro Ile Gln Thr Ala Ala Leu Gln Val 
        275                 280                 285             


Pro Thr Leu Val Gly Ser Ser Gly Thr Ile Leu Thr Thr Met Pro Val 
    290                 295                 300                 


Met Met Gly Gln Glu Lys Val Pro Ile Lys Gln Val Pro Gly Gly Val 
305                 310                 315                 320 


Lys Gln Leu Glu Pro Pro Lys Glu Gly Glu Arg Arg Thr Thr His Asn 
                325                 330                 335     


Ile Ile Glu Lys Arg Tyr Arg Ser Ser Ile Asn Asp Lys Ile Ile Glu 
            340                 345                 350         


Leu Lys Asp Leu Val Met Gly Thr Asp Ala Lys Met His Lys Ser Gly 
        355                 360                 365             


Val Leu Arg Lys Ala Ile Asp Tyr Ile Lys Tyr Leu Gln Gln Val Asn 
    370                 375                 380                 


His Lys Leu Arg Gln Glu Asn Met Val Leu Lys Leu Ala Asn Gln Lys 
385                 390                 395                 400 


Asn Lys Leu Leu Lys Gly Ile Asp Leu Gly Ser Leu Val Asp Asn Glu 
                405                 410                 415     


Val Asp Leu Lys Ile Glu Asp Phe Asn Gln Asn Val Leu Leu Met Ser 
            420                 425                 430         


Pro Pro Ala Ser Asp Ser Gly Ser Gln Ala Gly Phe Ser Pro Tyr Ser 
        435                 440                 445             


Ile Asp Ser Glu Pro Gly Ser Pro Leu Leu Asp Asp Ala Lys Val Lys 
    450                 455                 460                 


Asp Glu Pro Asp Ser Pro Pro Val Ala Leu Gly Met Val Asp Arg Ser 
465                 470                 475                 480 


Arg Ile Leu Leu Cys Val Leu Thr Phe Leu Cys Leu Ser Phe Asn Pro 
                485                 490                 495     


Leu Thr Ser Leu Leu Gln Trp Gly Gly Ala His Asp Ser Asp Gln His 
            500                 505                 510         


Pro His Ser Gly Ser Gly Arg Ser Val Leu Ser Phe Glu Ser Gly Ser 
        515                 520                 525             


Gly Gly Trp Phe Asp Trp Met Met Pro Thr Leu Leu Leu Trp Leu Val 
    530                 535                 540                 


Asn Gly Val Ile Val Leu Ser Val Phe Val Lys Leu Leu Val His Gly 
545                 550                 555                 560 


Glu Pro Val Ile Arg Pro His Ser Arg Ser Ser Val Thr Phe Trp Arg 
                565                 570                 575     


His Arg Lys Gln Ala Asp Leu Asp Leu Ala Arg Gly Asp Phe Ala Ala 
            580                 585                 590         


Ala Ala Gly Asn Leu Gln Thr Cys Leu Ala Val Leu Gly Arg Ala Leu 
        595                 600                 605             


Pro Thr Ser Arg Leu Asp Leu Ala Cys Ser Leu Ser Trp Asn Val Ile 
    610                 615                 620                 


Arg Tyr Ser Leu Gln Lys Leu Arg Leu Val Arg Trp Leu Leu Lys Lys 
625                 630                 635                 640 


Val Phe Gln Cys Arg Arg Ala Thr Pro Ala Thr Glu Ala Gly Phe Glu 
                645                 650                 655     


Asp Glu Ala Lys Thr Ser Ala Arg Asp Ala Ala Leu Ala Tyr His Arg 
            660                 665                 670         


Leu His Gln Leu His Ile Thr Gly Lys Leu Pro Ala Gly Ser Ala Cys 
        675                 680                 685             


Ser Asp Val His Met Ala Leu Cys Ala Val Asn Leu Ala Glu Cys Ala 
    690                 695                 700                 


Glu Glu Lys Ile Pro Pro Ser Thr Leu Val Glu Ile His Leu Thr Ala 
705                 710                 715                 720 


Ala Met Gly Leu Lys Thr Arg Cys Gly Gly Lys Leu Gly Phe Leu Ala 
                725                 730                 735     


Ser Tyr Phe Leu Ser Arg Ala Gln Ser Leu Cys Gly Pro Glu His Ser 
            740                 745                 750         


Ala Val Pro Asp Ser Leu Arg Trp Leu Cys His Pro Leu Gly Gln Lys 
        755                 760                 765             


Phe Phe Met Glu Arg Ser Trp Ser Val Lys Ser Ala Ala Lys Glu Ser 
    770                 775                 780                 


Leu Tyr Cys Ala Gln Arg Asn Pro Ala Asp Pro Ile Ala Gln Val His 
785                 790                 795                 800 


Gln Ala Phe Cys Lys Asn Leu Leu Glu Arg Ala Ile Glu Ser Leu Val 
                805                 810                 815     


Lys Pro Gln Ala Lys Lys Lys Ala Gly Asp Gln Glu Glu Glu Ser Cys 
            820                 825                 830         


Glu Phe Ser Ser Ala Leu Glu Tyr Leu Lys Leu Leu His Ser Phe Val 
        835                 840                 845             


Asp Ser Val Gly Val Met Ser Pro Pro Leu Ser Arg Ser Ser Val Leu 
    850                 855                 860                 


Lys Ser Ala Leu Gly Pro Asp Ile Ile Cys Arg Trp Trp Thr Ser Ala 
865                 870                 875                 880 


Ile Thr Val Ala Ile Ser Trp Leu Gln Gly Asp Asp Ala Ala Val Arg 
                885                 890                 895     


Ser His Phe Thr Lys Val Glu Arg Ile Pro Lys Ala Leu Glu Val Thr 
            900                 905                 910         


Glu Ser Pro Leu Val Lys Ala Ile Phe His Ala Cys Arg Ala Met His 
        915                 920                 925             


Ala Ser Leu Pro Gly Lys Ala Asp Gly Gln Gln Ser Ser Phe Cys His 
    930                 935                 940                 


Cys Glu Arg Ala Ser Gly His Leu Trp Ser Ser Leu Asn Val Ser Gly 
945                 950                 955                 960 


Ala Thr Ser Asp Pro Ala Leu Asn His Val Val Gln Leu Leu Thr Cys 
                965                 970                 975     


Asp Leu Leu Leu Ser Leu Arg Thr Ala Leu Trp Gln Lys Gln Ala Ser 
            980                 985                 990         


Ala Ser Gln Ala Val Gly Glu Thr  Tyr His Ala Ser Gly  Ala Glu Leu 
        995                 1000                 1005             


Ala Gly  Phe Gln Arg Asp Leu  Gly Ser Leu Arg Arg  Leu Ala His 
    1010                 1015                 1020             


Ser Phe  Arg Pro Ala Tyr Arg  Lys Val Phe Leu His  Glu Ala Thr 
    1025                 1030                 1035             


Val Arg  Leu Met Ala Gly Ala  Ser Pro Thr Arg Thr  His Gln Leu 
    1040                 1045                 1050             


Leu Glu  His Ser Leu Arg Arg  Arg Thr Thr Gln Ser  Thr Lys His 
    1055                 1060                 1065             


Gly Glu  Val Asp Ala Trp Pro  Gly Gln Arg Glu Arg  Ala Thr Ala 
    1070                 1075                 1080             


Ile Leu  Leu Ala Cys Arg His  Leu Pro Leu Ser Phe  Leu Ser Ser 
    1085                 1090                 1095             


Pro Gly  Gln Arg Ala Val Leu  Leu Ala Glu Ala Ala  Arg Thr Leu 
    1100                 1105                 1110             


Glu Lys  Val Gly Asp Arg Arg  Ser Cys Asn Asp Cys  Gln Gln Met 
    1115                 1120                 1125             


Ile Val  Lys Leu Gly Gly Gly  Thr Ala Ile Ala Ala  Ser 
    1130                 1135                 1140     


<210>  3
<211>  3020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized: Insulin induced gene 1 (INSIG 1)

<400>  3
cacgcccctg ggcggtgcgc gcgggcggtg ggtaggccgg gcaggctcac gtgatgcggg       60

ccccgcggcc cgccatataa acccgcgcgc ccgccaggcg ctgcggccgt cccgggccgt      120

gactcctcct ttcccccgcc ccgcctccgt tcggagagcc ggcgggcggg cgcctctcgg      180

ccaggaagcg cctcttggac gcgtgtgacc gatgcccaga ttgcacgacc acttctggag      240

ctgctcctgt gcgcacagcg cgaggcgccg aggccccccg cgagccagcg ccgcggggct      300

ggcggccaag gttggggaga tgatcaacgt ttccgtgtcc gggccctccc tgctggcggc      360

ccacggtgcc ccggacgctg accccgcgcc caggggccgc agtgctgcga tgagcggccc      420

cgagcccggc agcccctacc ccaacacctg gcatcatcgc ctgttgcaga ggagcctcgt      480

gctcttctcg gttggggtgg tcctagccct ggtgctcaac ctgctgcaga tccagaggaa      540

tgtcactctc ttccccgagg aggtgatcgc caccatcttt tcctccgcct ggtgggtccc      600

tccctgctgc gggacagcag ctgctgttgt tggcctactg tacccctgta tcgacagtca      660

cctcggagaa ccccacaaat ttaagagaga atgggccagt gtcatgcgct gcatagcagt      720

ttttgttggc attaaccacg ccagtgctaa attggatttt gccaataatg tccagctgtc      780

cttgacttta gcagccctat ctttgggcct ttggtggaca tttgatcgtt ccagaagtgg      840

ccttgggctg gggatcacca tagcttttct agctacgctg atcacgcagt ttctcgtgta      900

taatggtgtc tatcagtata catccccaga tttcctctat attcgttctt ggctcccttg      960

tatatttttc tcaggaggcg tcacggtggg gaacatagga cgacagttag ctatgggtgt     1020

tcctgaaaag ccccatagtg attgagtctt caaaaccacc gattctgaga gcaaggaaga     1080

ttttggaaga aaatctgact gtggattatg acaaagatta tcttttttct taagtaatct     1140

atttagatcg ggctgactgt acaaatgact cctggaaaaa actcttcacc tagtctagaa     1200

tagggaggtg gagaatgatg acttaccctg aagtcttccc ttgactgccc gcactggcgc     1260

ctgtctgtgc cctggagcat tctgcccagg ctacgtgggt tcaggcaggt ggcagcttcc     1320

caagtattcg atttcattca tgtgattaaa acaagttgcc atatttcaaa gccttgaact     1380

aagactcaat taccaacccg cagttttgtg tcagtgccca aaggaggtag gttgatggtg     1440

cttaacaaac atgaagtatg gtgtaatagg aataatattt atccaaaaga tttttaaaaa     1500

tagggctgtg tttaaaaaaa aaaacaaaac aagaaaagca gcagtgatta tagagaggtc     1560

acactctaag tggggtcgcg gcgtggccac gcttcacggt cacgctcgtc cgtcctgcag     1620

tggcgtgttt acatggtcac acgtgtgtgt atcaccagtg ggtcaactgc ttgtcattcc     1680

tcccgtggca gtttgtgtag acaatcttac tgagcaaaag gcaatgaaaa gtcttggttc     1740

ccacactgcg atatattgga attttcacct cagtttatga agtttatttc gaaatccata     1800

gtcatctaag aatgaatacc tgtctgccat gtatttcaat cttagtgagc caaaattgtt     1860

tgtttgttac tacagaatag agatgactgt tttttgccac agccctatgg aatttgcaat     1920

ctgtgattgc cttgtaaaaa ggagagtgca tatggcactg cattaaacgt gtggtgtttc     1980

tagtcaatga tattggtgag cacaatgtat tcatttaatg gcatagacca taccagacct     2040

aatttgcaag tattgggtct taaacttcaa gtgcaatgta tatgaaaacc aatctgagcc     2100

ttgtatctct taaatattta ttttttttaa cgtgtgagat gttcgagaga aggttctcca     2160

ttcatttcag tgctgcctgg aggaaactcg gcaatgattt ctttcagttg tgaagttcct     2220

ttcgtgttac accctccact gaaccctcaa ccttcgaaat actccagttt tgtgggtttg     2280

gtcattttta cttataaatt tacctttttg tattttgcaa tttacatgtg tttggtttgt     2340

tttaaattct gtgaaagtgg cttgattaaa agactccttt taaatggaag ccaccagtca     2400

gcagaatgga agcttagagg aacttgcctg tgagcgctgg tctttgtgtt tggttttgtg     2460

atgtaacgat ctttgctggg gttttttgct ttgttttgag ggaaatgtct tggagtaaat     2520

tttaagttcc tggagttaat ttgttttaca ggaattttgt tttttaaaaa aataggatca     2580

ttctgaactt tggaatgacc cccttatata ttttctgaaa atgaaaacag ttacatgaaa     2640

aaaatttcca atgaagatgt cagcatttta tgaaaaacca gaagttatta gatgaaagca     2700

gcgagtgaat ctttaaaaca gacttgatca cgcacacaca ataagtcttt ctctccgaaa     2760

ccggaagtaa atctatatct gttagaaata atgtagccaa aagaatgtaa atttgaggat     2820

ttttttgcca atagtttata gaaaatatat gaaccaaagt gatttgagtt tgtaaaaatg     2880

taaaatagta tgaacaaaat ttgcactcta ccagatttga acatctagtg aggttcacat     2940

tcatactaag ttttcaacat tgtgttcttt ttgcattcat tttttacttt tattaaaggt     3000

tcaaaaccaa aaaaaaaaaa                                                 3020


<210>  4
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized: Insulin induced gene 1 (INSIG 1) protein

<400>  4

Met Pro Arg Leu His Asp His Phe Trp Ser Cys Ser Cys Ala His Ser 
1               5                   10                  15      


Ala Arg Arg Arg Gly Pro Pro Arg Ala Ser Ala Ala Gly Leu Ala Ala 
            20                  25                  30          


Lys Val Gly Glu Met Ile Asn Val Ser Val Ser Gly Pro Ser Leu Leu 
        35                  40                  45              


Ala Ala His Gly Ala Pro Asp Ala Asp Pro Ala Pro Arg Gly Arg Ser 
    50                  55                  60                  


Ala Ala Met Ser Gly Pro Glu Pro Gly Ser Pro Tyr Pro Asn Thr Trp 
65                  70                  75                  80  


His His Arg Leu Leu Gln Arg Ser Leu Val Leu Phe Ser Val Gly Val 
                85                  90                  95      


Val Leu Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr 
            100                 105                 110         


Leu Phe Pro Glu Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp 
        115                 120                 125             


Val Pro Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr 
    130                 135                 140                 


Pro Cys Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu 
145                 150                 155                 160 


Trp Ala Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His 
                165                 170                 175     


Ala Ser Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr 
            180                 185                 190         


Leu Ala Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg 
        195                 200                 205             


Ser Gly Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile 
    210                 215                 220                 


Thr Gln Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp 
225                 230                 235                 240 


Phe Leu Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly 
                245                 250                 255     


Val Thr Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu 
            260                 265                 270         


Lys Pro His Ser Asp 
        275         


<210>  5
<211>  8481
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized: Fatty acid synthase (FASN) mRNA

<400>  5
gagagacggc agcggccccg gcctccctct ccgccgcgct tcagcctccc gctccgccgc       60

gctccagcct cgctctccgc cgcccgcacc gccgcccgcg ccctcaccag agcagccatg      120

gaggaggtgg tgattgccgg catgtccggg aagctgccag agtcggagaa cttgcaggag      180

ttctgggaca acctcatcgg cggtgtggac atggtcacgg acgatgaccg tcgctggaag      240

gcggggctct acggcctgcc ccggcggtcc ggcaagctga aggacctgtc taggtttgat      300

gcctccttct tcggagtcca ccccaagcag gcacacacga tggaccctca gctgcggctg      360

ctgctggaag tcacctatga agccatcgtg gacggaggca tcaacccaga ttcactccga      420

ggaacacaca ctggcgtctg ggtgggcgtg agcggctctg agacctcgga ggccctgagc      480

cgagaccccg agacactcgt gggctacagc atggtgggct gccagcgagc gatgatggcc      540

aaccggctct ccttcttctt cgacttcaga gggcccagca tcgcactgga cacagcctgc      600

tcctccagcc tgatggccct gcagaacgcc taccaggcca tccacagcgg gcagtgccct      660

gccgccatcg tggggggcat caatgtcctg ctgaagccca acacctccgt gcagttcttg      720

aggctgggga tgctcagccc cgagggcacc tgcaaggcct tcgacacagc ggggaatggg      780

tactgccgct cggagggtgt ggtggccgtc ctgctgacca agaagtccct ggcccggcgg      840

gtgtacgcca ccatcctgaa cgccggcacc aatacagatg gcttcaagga gcaaggcgtg      900

accttcccct caggggatat ccaggagcag ctcatccgct cgttgtacca gtcggccgga      960

gtggcccctg agtcatttga atacatcgaa gcccacggca caggcaccaa ggtgggcgac     1020

ccccaggagc tgaatggcat cacccgagcc ctgtgcgcca cccgccagga gccgctgctc     1080

atcggctcca ccaagtccaa catggggcac ccggagccag cctcggggct ggcagccctg     1140

gccaaggtgc tgctgtccct ggagcacggg ctctgggccc ccaacctgca cttccatagc     1200

cccaaccctg agatcccagc gctgttggat gggcggctgc aggtggtgga ccagcccctg     1260

cccgtccgtg gcggcaacgt gggcatcaac tcctttggct tcgggggctc caacgtgcac     1320

atcatcctga ggcccaacac gcagccgccc cccgcacccg ccccacatgc caccctgccc     1380

cgtctgctgc gggccagcgg acgcacccct gaggccgtgc agaagctgct ggagcagggc     1440

ctccggcaca gccaggacct ggctttcctg agcatgctga acgacatcgc ggctgtcccc     1500

gccaccgcca tgcccttccg tggctacgct gtgctgggtg gtgagcgcgg tggcccagag     1560

gtgcagcagg tgcccgctgg cgagcgcccg ctctggttca tctgctctgg gatgggcaca     1620

cagtggcgcg ggatggggct gagcctcatg cgcctggacc gcttccgaga ttccatccta     1680

cgctccgatg aggctgtgaa gccattcggc ctgaaggtgt cacagctgct gctgagcaca     1740

gacgagagca cctttgatga catcgtccat tcgtttgtga gcctgactgc catccagata     1800

ggcctcatag acctgctgag ctgcatgggg ctgaggccag atggcatcgt cggccactcc     1860

ctgggggagg tggcctgtgg ctacgccgac ggctgcctgt cccaggagga ggccgtcctc     1920

gctgcctact ggaggggaca gtgcatcaaa gaagcccatc tcccgccggg cgccatggca     1980

gccgtgggct tgtcctggga ggagtgtaaa cagcgctgcc ccccgggcgt ggtgcccgcc     2040

tgccacaact ccaaggacac agtcaccatc tcgggacctc aggccccggt gtttgagttc     2100

gtggagcagc tgaggaagga gggtgtgttt gccaaggagg tgcggaccgg cggtatggcc     2160

ttccactcct acttcatgga ggccatcgca cccccactgc tgcaggagct caagaaggtg     2220

atccgggagc cgaagccacg ttcagcccgc tggctcagca cctctatccc cgaggcccag     2280

tggcacagca gcctggcacg cacgtcctcc gccgagtaca atgtcaacaa cctggtgagc     2340

cctgtgctgt tccaggaggc cctgtggcac gtgcctgagc acgcggtggt gctggagatc     2400

gcgccccacg ccctgctgca ggctgtcctg aagcgtggcc tgaagccgag ctgcaccatc     2460

atccccctga tgaagaagga tcacagggac aacctggagt tcttcctggc cggcatcggc     2520

aggctgcacc tctcaggcat cgacgccaac cccaatgcct tgttcccacc tgtggagttc     2580

ccagctcccc gaggaactcc cctcatctcc ccactcatca agtgggacca cagcctggcc     2640

tgggacgtgc cggccgccga ggacttcccc aacggttcag gttccccctc agccgccatc     2700

tacaacatcg acaccagctc cgagtctcct gaccactacc tggtggacca caccctcgac     2760

ggtcgcgtcc tcttccccgc cactggctac ctgagcatag tgtggaagac gctggcccgc     2820

gccctgggcc tgggcgtcga gcagctgcct gtggtgtttg aggatgtggt gctgcaccag     2880

gccaccatcc tgcccaagac tgggacagtg tccctggagg tacggctcct ggaggcctcc     2940

cgtgccttcg aggtgtcaga gaacggcaac ctggtagtga gtgggaaggt gtaccagtgg     3000

gatgaccctg accccaggct cttcgaccac ccggaaagcc ccacccccaa ccccacggag     3060

cccctcttcc tggcccaggc tgaagtttac aaggagctgc gtctgcgtgg ctacgactac     3120

ggccctcatt tccagggcat cctggaggcc agcctggaag gtgactcggg gaggctgctg     3180

tggaaggata actgggtgag cttcatggac accatgctgc agatgtccat cctgggctcg     3240

gccaagcacg gcctgtacct gcccacccgt gtcaccgcca tccacatcga ccctgccacc     3300

cacaggcaga agctgtacac actgcaggac aaggcccaag tggctgacgt ggtggtgagc     3360

aggtggctga gggtcacagt ggccggaggc gtccacatct ccgggctcca cactgagtcg     3420

gccccgcggc ggcagcagga gcagcaggtg cccatcctgg agaagttttg cttcactccc     3480

cacacggagg aggggtgcct gtctgagcgc gctgccctgc aggaggagct gcaactgtgc     3540

aaggggctgg tgcaggcact gcagaccaag gtgacccagc aggggctgaa gatggtggtg     3600

cccggactgg atggggccca gatcccccgg gacccctcac agcaggaact gccccggctg     3660

ttgtcggctg cctgcaggct tcagctcaac gggaacctgc agctggagct ggcgcaggtg     3720

ctggcccagg agaggcccaa gctgccagag gaccctctgc tcagcggcct cctggactcc     3780

ccggcactca aggcctgcct ggacactgcc gtggagaaca tgcccagcct gaagatgaag     3840

gtggtggagg tgctggctgg ccacggtcac ctgtattccc gcatcccagg cctgctcagc     3900

ccccatcccc tgctgcagct gagctacacg gccaccgacc gccaccccca ggccctggag     3960

gctgcccagg ccgagctgca gcagcacgac gttgcccagg gccagtggga tcccgcagac     4020

cctgccccca gcgccctggg cagcgccgac ctcctggtgt gcaactgtgc tgtggctgcc     4080

ctcggggacc cggcctcagc tctcagcaac atggtggctg ccctgagaga agggggcttt     4140

ctgctcctgc acacactgct ccgggggcac cccctcgggg acatcgtggc cttcctcacc     4200

tccactgagc cgcagtatgg ccagggcatc ctgagccagg acgcgtggga gagcctcttc     4260

tccagggtgt cgctgcgcct ggtgggcctg aagaagtcct tctacggctc cacgctcttc     4320

ctgtgccgcc ggcccacccc gcaggacagc cccatcttcc tgccggtgga cgataccagc     4380

ttccgctggg tggagtctct gaagggcatc ctggctgacg aagactcttc ccggcctgtg     4440

tggctgaagg ccatcaactg tgccacctcg ggcgtggtgg gcttggtgaa ctgtctccgc     4500

cgagagcccg gcgggaaccg cctccggtgt gtgctgctct ccaacctcag cagcacctcc     4560

cacgtcccgg aggtggaccc gggctccgca gaactgcaga aggtgttgca gggagacctg     4620

gtgatgaacg tctaccgcga cggggcctgg ggggctttcc gccacttcct gctggaggag     4680

gacaagcctg aggagccgac ggcacatgcc tttgtgagca ccctcacccg gggggacctg     4740

tcctccatcc gctgggtctg ctcctcgctg cgccatgccc agcccacctg ccctggcgcc     4800

cagctctgca cggtctacta cgcctccctc aacttccgcg acatcatgct ggccactggc     4860

aagctgtccc ctgatgccat cccagggaag tggacctccc aggacagcct gctaggtatg     4920

gagttctcgg gccgagacgc cagcggcaag cgtgtgatgg gactggtgcc tgccaagggc     4980

ctggccacct ctgtcctgct gtcaccggac ttcctctggg atgtgccttc caactggacg     5040

ctggaggagg cggcctcggt gcctgtcgtc tacagcacgg cctactacgc gctggtggtg     5100

cgtgggcggg tgcgccccgg ggagacgctg ctcatccact cgggctcggg cggcgtgggc     5160

caggccgcca tcgccatcgc cctcagtctg ggctgccgcg tcttcaccac cgtggggtcg     5220

gctgagaagc gggcgtacct ccaggccagg ttcccccagc tcgacagcac cagcttcgcc     5280

aactcccggg acacatcctt cgagcagcat gtgctgtggc acacgggcgg gaagggcgtt     5340

gacctggtct tgaactcctt ggcggaagag aagctgcagg ccagcgtgag gtgcttggct     5400

acgcacggtc gcttcctgga aattggcaaa ttcgaccttt ctcagaacca cccgctcggc     5460

atggctatct tcctgaagaa cgtgacattc cacggggtcc tactggatgc gttcttcaac     5520

gagagcagtg ctgactggcg ggaggtgtgg gcgcttgtgc aggccggcat ccgggatggg     5580

gtggtacggc ccctcaagtg cacggtgttc catggggccc aggtggagga cgccttccgc     5640

tacatggccc aagggaagca cattggcaaa gtcgtcgtgc aggtgcttgc ggaggagccg     5700

gaggcagtgc tgaagggggc caaacccaag ctgatgtcgg ccatctccaa gaccttctgc     5760

ccggcccaca agagctacat catcgctggt ggtctgggtg gcttcggcct ggagttggcg     5820

cagtggctga tacagcgtgg ggtgcagaag ctcgtgttga cttctcgctc cgggatccgg     5880

acaggctacc aggccaagca ggtccgccgg tggaggcgcc agggcgtaca ggtgcaggtg     5940

tccaccagca acatcagctc actggagggg gcccggggcc tcattgccga ggcggcgcag     6000

cttgggcccg tgggcggcgt cttcaacctg gccgtggtct tgagagatgg cttgctggag     6060

aaccagaccc cagagttctt ccaggacgtc tgcaagccca agtacagcgg caccctgaac     6120

ctggacaggg tgacccgaga ggcgtgccct gagctggact actttgtggt cttctcctct     6180

gtgagctgcg ggcgtggcaa tgcgggacag agcaactacg gctttgccaa ttccgccatg     6240

gagcgtatct gtgagaaacg ccggcacgaa ggcctcccag gcctggccgt gcagtggggc     6300

gccatcggcg acgtgggcat tttggtggag acgatgagca ccaacgacac gatcgtcagt     6360

ggcacgctgc cccagcgcat ggcgtcctgc ctggaggtgc tggacctctt cctgaaccag     6420

ccccacatgg tcctgagcag ctttgtgctg gctgagaagg ctgcggccta tagggacagg     6480

gacagccagc gggacctggt ggaggccgtg gcacacatcc tgggcatccg cgacttggct     6540

gctgtcaacc tggacagctc actggcggac ctgggcctgg actcgctcat gagcgtggag     6600

gtgcgccaga cgctggagcg tgagctcaac ctggtgctgt ccgtgcgcga ggtgcggcaa     6660

ctcacgctcc ggaaactgca ggagctgtcc tcaaaggcgg atgaggccag cgagctggca     6720

tgccccacgc ccaaggagga tggtctggcc cagcagcaga ctcagctgaa cctgcgctcc     6780

ctgctggtga acccggaggg ccccaccctg atgcggctca actccgtgca gagctcggag     6840

cggcccctgt tcctggtgca cccaatcgag ggctccacca ccgtgttcca cagcctggcc     6900

tcccggctca gcatccccac ctatggcctg cagtgcaccc gagctgcgcc ccttgacagc     6960

atccacagcc tggctgccta ctacatcgac tgcatcaggc aggtgcagcc cgagggcccc     7020

taccgcgtgg ccggctactc ctacggggcc tgcgtggcct ttgaaatgtg ctcccagctg     7080

caggcccagc agagcccagc ccccacccac aacagcctct tcctgttcga cggctcgccc     7140

acctacgtac tggcctacac ccagagctac cgggcaaagc tgaccccagg ctgtgaggct     7200

gaggctgaga cggaggccat atgcttcttc gtgcagcagt tcacggacat ggagcacaac     7260

agggtgctgg aggcgctgct gccgctgaag ggcctagagg agcgtgtggc agccgccgtg     7320

gacctgatca tcaagagcca ccagggcctg gaccgccagg agctgagctt tgcggcccgg     7380

tccttctact acaagctgcg tgccgctgag cagtacacac ccaaggccaa gtaccatggc     7440

aacgtgatgc tactgcgcgc caagacgggt ggcgcctacg gcgaggacct gggcgcggac     7500

tacaacctct cccaggtatg cgacgggaaa gtatccgtcc acgtcatcga gggtgaccac     7560

cgcacgctgc tggagggcag cggcctggag tccatcatca gcatcatcca cagctccctg     7620

gctgagccac gcgtgagcgt gcgggagggc taggcccgtg cccccgcctg ccaccggagg     7680

tcactccacc atccccaccc caccccaccc cacccccgcc atgcaacggg attgaagggt     7740

cctgccggtg ggaccctgtc cggcccagtg ccactgcccc ccgaggctgc tagatgtagg     7800

tgttaggcat gtcccaccca cccgccgcct cccacggcac ctcggggaca ccagagctgc     7860

cgacttggag actcctggtc tgtgaagagc cggtggtgcc cgtgcccgca ggaactgggc     7920

tgggcctcgt gcgcccgtgg ggtctgcgct tggtctttct gtgcttggat ttgcatattt     7980

attgcattgc tggtagagac ccccaggcct gtccaccctg ccaagactcc tcaggcagcg     8040

tgtgggtccc gcactctgcc cccatttccc cgatgtcccc tgcgggcgcg ggcagccacc     8100

caagcctgct ggctgcggcc ccctctcggc caggcattgg ctcagcccgc tgagtggggg     8160

gtcgtgggcc agtccccgag gagctgggcc cctgcacagg cacacagggc ccggccacac     8220

ccagcggccc cccgcacagc cacccgtggg gtgctgccct tatgcccggc gccgggcacc     8280

aactccatgt ttggtgtttg tctgtgtttg tttttcaaga aatgattcaa attgctgctt     8340

ggattttgaa atttactgta actgtcagtg tacacgtctg gaccccgttt catttttaca     8400

ccaatttggt aaaaatgctg ctctcagcct cccacaatta aaccgcatgt gatctccaaa     8460

aaaaaaaaaa aaaaaaaaaa a                                               8481


<210>  6
<211>  2511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized: Fatty acid synthase (FASN) protein

<400>  6

Met Glu Glu Val Val Ile Ala Gly Met Ser Gly Lys Leu Pro Glu Ser 
1               5                   10                  15      


Glu Asn Leu Gln Glu Phe Trp Asp Asn Leu Ile Gly Gly Val Asp Met 
            20                  25                  30          


Val Thr Asp Asp Asp Arg Arg Trp Lys Ala Gly Leu Tyr Gly Leu Pro 
        35                  40                  45              


Arg Arg Ser Gly Lys Leu Lys Asp Leu Ser Arg Phe Asp Ala Ser Phe 
    50                  55                  60                  


Phe Gly Val His Pro Lys Gln Ala His Thr Met Asp Pro Gln Leu Arg 
65                  70                  75                  80  


Leu Leu Leu Glu Val Thr Tyr Glu Ala Ile Val Asp Gly Gly Ile Asn 
                85                  90                  95      


Pro Asp Ser Leu Arg Gly Thr His Thr Gly Val Trp Val Gly Val Ser 
            100                 105                 110         


Gly Ser Glu Thr Ser Glu Ala Leu Ser Arg Asp Pro Glu Thr Leu Val 
        115                 120                 125             


Gly Tyr Ser Met Val Gly Cys Gln Arg Ala Met Met Ala Asn Arg Leu 
    130                 135                 140                 


Ser Phe Phe Phe Asp Phe Arg Gly Pro Ser Ile Ala Leu Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Met Ala Leu Gln Asn Ala Tyr Gln Ala Ile His 
                165                 170                 175     


Ser Gly Gln Cys Pro Ala Ala Ile Val Gly Gly Ile Asn Val Leu Leu 
            180                 185                 190         


Lys Pro Asn Thr Ser Val Gln Phe Leu Arg Leu Gly Met Leu Ser Pro 
        195                 200                 205             


Glu Gly Thr Cys Lys Ala Phe Asp Thr Ala Gly Asn Gly Tyr Cys Arg 
    210                 215                 220                 


Ser Glu Gly Val Val Ala Val Leu Leu Thr Lys Lys Ser Leu Ala Arg 
225                 230                 235                 240 


Arg Val Tyr Ala Thr Ile Leu Asn Ala Gly Thr Asn Thr Asp Gly Phe 
                245                 250                 255     


Lys Glu Gln Gly Val Thr Phe Pro Ser Gly Asp Ile Gln Glu Gln Leu 
            260                 265                 270         


Ile Arg Ser Leu Tyr Gln Ser Ala Gly Val Ala Pro Glu Ser Phe Glu 
        275                 280                 285             


Tyr Ile Glu Ala His Gly Thr Gly Thr Lys Val Gly Asp Pro Gln Glu 
    290                 295                 300                 


Leu Asn Gly Ile Thr Arg Ala Leu Cys Ala Thr Arg Gln Glu Pro Leu 
305                 310                 315                 320 


Leu Ile Gly Ser Thr Lys Ser Asn Met Gly His Pro Glu Pro Ala Ser 
                325                 330                 335     


Gly Leu Ala Ala Leu Ala Lys Val Leu Leu Ser Leu Glu His Gly Leu 
            340                 345                 350         


Trp Ala Pro Asn Leu His Phe His Ser Pro Asn Pro Glu Ile Pro Ala 
        355                 360                 365             


Leu Leu Asp Gly Arg Leu Gln Val Val Asp Gln Pro Leu Pro Val Arg 
    370                 375                 380                 


Gly Gly Asn Val Gly Ile Asn Ser Phe Gly Phe Gly Gly Ser Asn Val 
385                 390                 395                 400 


His Ile Ile Leu Arg Pro Asn Thr Gln Pro Pro Pro Ala Pro Ala Pro 
                405                 410                 415     


His Ala Thr Leu Pro Arg Leu Leu Arg Ala Ser Gly Arg Thr Pro Glu 
            420                 425                 430         


Ala Val Gln Lys Leu Leu Glu Gln Gly Leu Arg His Ser Gln Asp Leu 
        435                 440                 445             


Ala Phe Leu Ser Met Leu Asn Asp Ile Ala Ala Val Pro Ala Thr Ala 
    450                 455                 460                 


Met Pro Phe Arg Gly Tyr Ala Val Leu Gly Gly Glu Arg Gly Gly Pro 
465                 470                 475                 480 


Glu Val Gln Gln Val Pro Ala Gly Glu Arg Pro Leu Trp Phe Ile Cys 
                485                 490                 495     


Ser Gly Met Gly Thr Gln Trp Arg Gly Met Gly Leu Ser Leu Met Arg 
            500                 505                 510         


Leu Asp Arg Phe Arg Asp Ser Ile Leu Arg Ser Asp Glu Ala Val Lys 
        515                 520                 525             


Pro Phe Gly Leu Lys Val Ser Gln Leu Leu Leu Ser Thr Asp Glu Ser 
    530                 535                 540                 


Thr Phe Asp Asp Ile Val His Ser Phe Val Ser Leu Thr Ala Ile Gln 
545                 550                 555                 560 


Ile Gly Leu Ile Asp Leu Leu Ser Cys Met Gly Leu Arg Pro Asp Gly 
                565                 570                 575     


Ile Val Gly His Ser Leu Gly Glu Val Ala Cys Gly Tyr Ala Asp Gly 
            580                 585                 590         


Cys Leu Ser Gln Glu Glu Ala Val Leu Ala Ala Tyr Trp Arg Gly Gln 
        595                 600                 605             


Cys Ile Lys Glu Ala His Leu Pro Pro Gly Ala Met Ala Ala Val Gly 
    610                 615                 620                 


Leu Ser Trp Glu Glu Cys Lys Gln Arg Cys Pro Pro Gly Val Val Pro 
625                 630                 635                 640 


Ala Cys His Asn Ser Lys Asp Thr Val Thr Ile Ser Gly Pro Gln Ala 
                645                 650                 655     


Pro Val Phe Glu Phe Val Glu Gln Leu Arg Lys Glu Gly Val Phe Ala 
            660                 665                 670         


Lys Glu Val Arg Thr Gly Gly Met Ala Phe His Ser Tyr Phe Met Glu 
        675                 680                 685             


Ala Ile Ala Pro Pro Leu Leu Gln Glu Leu Lys Lys Val Ile Arg Glu 
    690                 695                 700                 


Pro Lys Pro Arg Ser Ala Arg Trp Leu Ser Thr Ser Ile Pro Glu Ala 
705                 710                 715                 720 


Gln Trp His Ser Ser Leu Ala Arg Thr Ser Ser Ala Glu Tyr Asn Val 
                725                 730                 735     


Asn Asn Leu Val Ser Pro Val Leu Phe Gln Glu Ala Leu Trp His Val 
            740                 745                 750         


Pro Glu His Ala Val Val Leu Glu Ile Ala Pro His Ala Leu Leu Gln 
        755                 760                 765             


Ala Val Leu Lys Arg Gly Leu Lys Pro Ser Cys Thr Ile Ile Pro Leu 
    770                 775                 780                 


Met Lys Lys Asp His Arg Asp Asn Leu Glu Phe Phe Leu Ala Gly Ile 
785                 790                 795                 800 


Gly Arg Leu His Leu Ser Gly Ile Asp Ala Asn Pro Asn Ala Leu Phe 
                805                 810                 815     


Pro Pro Val Glu Phe Pro Ala Pro Arg Gly Thr Pro Leu Ile Ser Pro 
            820                 825                 830         


Leu Ile Lys Trp Asp His Ser Leu Ala Trp Asp Val Pro Ala Ala Glu 
        835                 840                 845             


Asp Phe Pro Asn Gly Ser Gly Ser Pro Ser Ala Ala Ile Tyr Asn Ile 
    850                 855                 860                 


Asp Thr Ser Ser Glu Ser Pro Asp His Tyr Leu Val Asp His Thr Leu 
865                 870                 875                 880 


Asp Gly Arg Val Leu Phe Pro Ala Thr Gly Tyr Leu Ser Ile Val Trp 
                885                 890                 895     


Lys Thr Leu Ala Arg Ala Leu Gly Leu Gly Val Glu Gln Leu Pro Val 
            900                 905                 910         


Val Phe Glu Asp Val Val Leu His Gln Ala Thr Ile Leu Pro Lys Thr 
        915                 920                 925             


Gly Thr Val Ser Leu Glu Val Arg Leu Leu Glu Ala Ser Arg Ala Phe 
    930                 935                 940                 


Glu Val Ser Glu Asn Gly Asn Leu Val Val Ser Gly Lys Val Tyr Gln 
945                 950                 955                 960 


Trp Asp Asp Pro Asp Pro Arg Leu Phe Asp His Pro Glu Ser Pro Thr 
                965                 970                 975     


Pro Asn Pro Thr Glu Pro Leu Phe Leu Ala Gln Ala Glu Val Tyr Lys 
            980                 985                 990         


Glu Leu Arg Leu Arg Gly Tyr Asp  Tyr Gly Pro His Phe  Gln Gly Ile 
        995                 1000                 1005             


Leu Glu  Ala Ser Leu Glu Gly  Asp Ser Gly Arg Leu  Leu Trp Lys 
    1010                 1015                 1020             


Asp Asn  Trp Val Ser Phe Met  Asp Thr Met Leu Gln  Met Ser Ile 
    1025                 1030                 1035             


Leu Gly  Ser Ala Lys His Gly  Leu Tyr Leu Pro Thr  Arg Val Thr 
    1040                 1045                 1050             


Ala Ile  His Ile Asp Pro Ala  Thr His Arg Gln Lys  Leu Tyr Thr 
    1055                 1060                 1065             


Leu Gln  Asp Lys Ala Gln Val  Ala Asp Val Val Val  Ser Arg Trp 
    1070                 1075                 1080             


Leu Arg  Val Thr Val Ala Gly  Gly Val His Ile Ser  Gly Leu His 
    1085                 1090                 1095             


Thr Glu  Ser Ala Pro Arg Arg  Gln Gln Glu Gln Gln  Val Pro Ile 
    1100                 1105                 1110             


Leu Glu  Lys Phe Cys Phe Thr  Pro His Thr Glu Glu  Gly Cys Leu 
    1115                 1120                 1125             


Ser Glu  Arg Ala Ala Leu Gln  Glu Glu Leu Gln Leu  Cys Lys Gly 
    1130                 1135                 1140             


Leu Val  Gln Ala Leu Gln Thr  Lys Val Thr Gln Gln  Gly Leu Lys 
    1145                 1150                 1155             


Met Val  Val Pro Gly Leu Asp  Gly Ala Gln Ile Pro  Arg Asp Pro 
    1160                 1165                 1170             


Ser Gln  Gln Glu Leu Pro Arg  Leu Leu Ser Ala Ala  Cys Arg Leu 
    1175                 1180                 1185             


Gln Leu  Asn Gly Asn Leu Gln  Leu Glu Leu Ala Gln  Val Leu Ala 
    1190                 1195                 1200             


Gln Glu  Arg Pro Lys Leu Pro  Glu Asp Pro Leu Leu  Ser Gly Leu 
    1205                 1210                 1215             


Leu Asp  Ser Pro Ala Leu Lys  Ala Cys Leu Asp Thr  Ala Val Glu 
    1220                 1225                 1230             


Asn Met  Pro Ser Leu Lys Met  Lys Val Val Glu Val  Leu Ala Gly 
    1235                 1240                 1245             


His Gly  His Leu Tyr Ser Arg  Ile Pro Gly Leu Leu  Ser Pro His 
    1250                 1255                 1260             


Pro Leu  Leu Gln Leu Ser Tyr  Thr Ala Thr Asp Arg  His Pro Gln 
    1265                 1270                 1275             


Ala Leu  Glu Ala Ala Gln Ala  Glu Leu Gln Gln His  Asp Val Ala 
    1280                 1285                 1290             


Gln Gly  Gln Trp Asp Pro Ala  Asp Pro Ala Pro Ser  Ala Leu Gly 
    1295                 1300                 1305             


Ser Ala  Asp Leu Leu Val Cys  Asn Cys Ala Val Ala  Ala Leu Gly 
    1310                 1315                 1320             


Asp Pro  Ala Ser Ala Leu Ser  Asn Met Val Ala Ala  Leu Arg Glu 
    1325                 1330                 1335             


Gly Gly  Phe Leu Leu Leu His  Thr Leu Leu Arg Gly  His Pro Leu 
    1340                 1345                 1350             


Gly Asp  Ile Val Ala Phe Leu  Thr Ser Thr Glu Pro  Gln Tyr Gly 
    1355                 1360                 1365             


Gln Gly  Ile Leu Ser Gln Asp  Ala Trp Glu Ser Leu  Phe Ser Arg 
    1370                 1375                 1380             


Val Ser  Leu Arg Leu Val Gly  Leu Lys Lys Ser Phe  Tyr Gly Ser 
    1385                 1390                 1395             


Thr Leu  Phe Leu Cys Arg Arg  Pro Thr Pro Gln Asp  Ser Pro Ile 
    1400                 1405                 1410             


Phe Leu  Pro Val Asp Asp Thr  Ser Phe Arg Trp Val  Glu Ser Leu 
    1415                 1420                 1425             


Lys Gly  Ile Leu Ala Asp Glu  Asp Ser Ser Arg Pro  Val Trp Leu 
    1430                 1435                 1440             


Lys Ala  Ile Asn Cys Ala Thr  Ser Gly Val Val Gly  Leu Val Asn 
    1445                 1450                 1455             


Cys Leu  Arg Arg Glu Pro Gly  Gly Asn Arg Leu Arg  Cys Val Leu 
    1460                 1465                 1470             


Leu Ser  Asn Leu Ser Ser Thr  Ser His Val Pro Glu  Val Asp Pro 
    1475                 1480                 1485             


Gly Ser  Ala Glu Leu Gln Lys  Val Leu Gln Gly Asp  Leu Val Met 
    1490                 1495                 1500             


Asn Val  Tyr Arg Asp Gly Ala  Trp Gly Ala Phe Arg  His Phe Leu 
    1505                 1510                 1515             


Leu Glu  Glu Asp Lys Pro Glu  Glu Pro Thr Ala His  Ala Phe Val 
    1520                 1525                 1530             


Ser Thr  Leu Thr Arg Gly Asp  Leu Ser Ser Ile Arg  Trp Val Cys 
    1535                 1540                 1545             


Ser Ser  Leu Arg His Ala Gln  Pro Thr Cys Pro Gly  Ala Gln Leu 
    1550                 1555                 1560             


Cys Thr  Val Tyr Tyr Ala Ser  Leu Asn Phe Arg Asp  Ile Met Leu 
    1565                 1570                 1575             


Ala Thr  Gly Lys Leu Ser Pro  Asp Ala Ile Pro Gly  Lys Trp Thr 
    1580                 1585                 1590             


Ser Gln  Asp Ser Leu Leu Gly  Met Glu Phe Ser Gly  Arg Asp Ala 
    1595                 1600                 1605             


Ser Gly  Lys Arg Val Met Gly  Leu Val Pro Ala Lys  Gly Leu Ala 
    1610                 1615                 1620             


Thr Ser  Val Leu Leu Ser Pro  Asp Phe Leu Trp Asp  Val Pro Ser 
    1625                 1630                 1635             


Asn Trp  Thr Leu Glu Glu Ala  Ala Ser Val Pro Val  Val Tyr Ser 
    1640                 1645                 1650             


Thr Ala  Tyr Tyr Ala Leu Val  Val Arg Gly Arg Val  Arg Pro Gly 
    1655                 1660                 1665             


Glu Thr  Leu Leu Ile His Ser  Gly Ser Gly Gly Val  Gly Gln Ala 
    1670                 1675                 1680             


Ala Ile  Ala Ile Ala Leu Ser  Leu Gly Cys Arg Val  Phe Thr Thr 
    1685                 1690                 1695             


Val Gly  Ser Ala Glu Lys Arg  Ala Tyr Leu Gln Ala  Arg Phe Pro 
    1700                 1705                 1710             


Gln Leu  Asp Ser Thr Ser Phe  Ala Asn Ser Arg Asp  Thr Ser Phe 
    1715                 1720                 1725             


Glu Gln  His Val Leu Trp His  Thr Gly Gly Lys Gly  Val Asp Leu 
    1730                 1735                 1740             


Val Leu  Asn Ser Leu Ala Glu  Glu Lys Leu Gln Ala  Ser Val Arg 
    1745                 1750                 1755             


Cys Leu  Ala Thr His Gly Arg  Phe Leu Glu Ile Gly  Lys Phe Asp 
    1760                 1765                 1770             


Leu Ser  Gln Asn His Pro Leu  Gly Met Ala Ile Phe  Leu Lys Asn 
    1775                 1780                 1785             


Val Thr  Phe His Gly Val Leu  Leu Asp Ala Phe Phe  Asn Glu Ser 
    1790                 1795                 1800             


Ser Ala  Asp Trp Arg Glu Val  Trp Ala Leu Val Gln  Ala Gly Ile 
    1805                 1810                 1815             


Arg Asp  Gly Val Val Arg Pro  Leu Lys Cys Thr Val  Phe His Gly 
    1820                 1825                 1830             


Ala Gln  Val Glu Asp Ala Phe  Arg Tyr Met Ala Gln  Gly Lys His 
    1835                 1840                 1845             


Ile Gly  Lys Val Val Val Gln  Val Leu Ala Glu Glu  Pro Glu Ala 
    1850                 1855                 1860             


Val Leu  Lys Gly Ala Lys Pro  Lys Leu Met Ser Ala  Ile Ser Lys 
    1865                 1870                 1875             


Thr Phe  Cys Pro Ala His Lys  Ser Tyr Ile Ile Ala  Gly Gly Leu 
    1880                 1885                 1890             


Gly Gly  Phe Gly Leu Glu Leu  Ala Gln Trp Leu Ile  Gln Arg Gly 
    1895                 1900                 1905             


Val Gln  Lys Leu Val Leu Thr  Ser Arg Ser Gly Ile  Arg Thr Gly 
    1910                 1915                 1920             


Tyr Gln  Ala Lys Gln Val Arg  Arg Trp Arg Arg Gln  Gly Val Gln 
    1925                 1930                 1935             


Val Gln  Val Ser Thr Ser Asn  Ile Ser Ser Leu Glu  Gly Ala Arg 
    1940                 1945                 1950             


Gly Leu  Ile Ala Glu Ala Ala  Gln Leu Gly Pro Val  Gly Gly Val 
    1955                 1960                 1965             


Phe Asn  Leu Ala Val Val Leu  Arg Asp Gly Leu Leu  Glu Asn Gln 
    1970                 1975                 1980             


Thr Pro  Glu Phe Phe Gln Asp  Val Cys Lys Pro Lys  Tyr Ser Gly 
    1985                 1990                 1995             


Thr Leu  Asn Leu Asp Arg Val  Thr Arg Glu Ala Cys  Pro Glu Leu 
    2000                 2005                 2010             


Asp Tyr  Phe Val Val Phe Ser  Ser Val Ser Cys Gly  Arg Gly Asn 
    2015                 2020                 2025             


Ala Gly  Gln Ser Asn Tyr Gly  Phe Ala Asn Ser Ala  Met Glu Arg 
    2030                 2035                 2040             


Ile Cys  Glu Lys Arg Arg His  Glu Gly Leu Pro Gly  Leu Ala Val 
    2045                 2050                 2055             


Gln Trp  Gly Ala Ile Gly Asp  Val Gly Ile Leu Val  Glu Thr Met 
    2060                 2065                 2070             


Ser Thr  Asn Asp Thr Ile Val  Ser Gly Thr Leu Pro  Gln Arg Met 
    2075                 2080                 2085             


Ala Ser  Cys Leu Glu Val Leu  Asp Leu Phe Leu Asn  Gln Pro His 
    2090                 2095                 2100             


Met Val  Leu Ser Ser Phe Val  Leu Ala Glu Lys Ala  Ala Ala Tyr 
    2105                 2110                 2115             


Arg Asp  Arg Asp Ser Gln Arg  Asp Leu Val Glu Ala  Val Ala His 
    2120                 2125                 2130             


Ile Leu  Gly Ile Arg Asp Leu  Ala Ala Val Asn Leu  Asp Ser Ser 
    2135                 2140                 2145             


Leu Ala  Asp Leu Gly Leu Asp  Ser Leu Met Ser Val  Glu Val Arg 
    2150                 2155                 2160             


Gln Thr  Leu Glu Arg Glu Leu  Asn Leu Val Leu Ser  Val Arg Glu 
    2165                 2170                 2175             


Val Arg  Gln Leu Thr Leu Arg  Lys Leu Gln Glu Leu  Ser Ser Lys 
    2180                 2185                 2190             


Ala Asp  Glu Ala Ser Glu Leu  Ala Cys Pro Thr Pro  Lys Glu Asp 
    2195                 2200                 2205             


Gly Leu  Ala Gln Gln Gln Thr  Gln Leu Asn Leu Arg  Ser Leu Leu 
    2210                 2215                 2220             


Val Asn  Pro Glu Gly Pro Thr  Leu Met Arg Leu Asn  Ser Val Gln 
    2225                 2230                 2235             


Ser Ser  Glu Arg Pro Leu Phe  Leu Val His Pro Ile  Glu Gly Ser 
    2240                 2245                 2250             


Thr Thr  Val Phe His Ser Leu  Ala Ser Arg Leu Ser  Ile Pro Thr 
    2255                 2260                 2265             


Tyr Gly  Leu Gln Cys Thr Arg  Ala Ala Pro Leu Asp  Ser Ile His 
    2270                 2275                 2280             


Ser Leu  Ala Ala Tyr Tyr Ile  Asp Cys Ile Arg Gln  Val Gln Pro 
    2285                 2290                 2295             


Glu Gly  Pro Tyr Arg Val Ala  Gly Tyr Ser Tyr Gly  Ala Cys Val 
    2300                 2305                 2310             


Ala Phe  Glu Met Cys Ser Gln  Leu Gln Ala Gln Gln  Ser Pro Ala 
    2315                 2320                 2325             


Pro Thr  His Asn Ser Leu Phe  Leu Phe Asp Gly Ser  Pro Thr Tyr 
    2330                 2335                 2340             


Val Leu  Ala Tyr Thr Gln Ser  Tyr Arg Ala Lys Leu  Thr Pro Gly 
    2345                 2350                 2355             


Cys Glu  Ala Glu Ala Glu Thr  Glu Ala Ile Cys Phe  Phe Val Gln 
    2360                 2365                 2370             


Gln Phe  Thr Asp Met Glu His  Asn Arg Val Leu Glu  Ala Leu Leu 
    2375                 2380                 2385             


Pro Leu  Lys Gly Leu Glu Glu  Arg Val Ala Ala Ala  Val Asp Leu 
    2390                 2395                 2400             


Ile Ile  Lys Ser His Gln Gly  Leu Asp Arg Gln Glu  Leu Ser Phe 
    2405                 2410                 2415             


Ala Ala  Arg Ser Phe Tyr Tyr  Lys Leu Arg Ala Ala  Glu Gln Tyr 
    2420                 2425                 2430             


Thr Pro  Lys Ala Lys Tyr His  Gly Asn Val Met Leu  Leu Arg Ala 
    2435                 2440                 2445             


Lys Thr  Gly Gly Ala Tyr Gly  Glu Asp Leu Gly Ala  Asp Tyr Asn 
    2450                 2455                 2460             


Leu Ser  Gln Val Cys Asp Gly  Lys Val Ser Val His  Val Ile Glu 
    2465                 2470                 2475             


Gly Asp  His Arg Thr Leu Leu  Glu Gly Ser Gly Leu  Glu Ser Ile 
    2480                 2485                 2490             


Ile Ser  Ile Ile His Ser Ser  Leu Ala Glu Pro Arg  Val Ser Val 
    2495                 2500                 2505             


Arg Glu  Gly 
    2510     


<210>  7
<211>  3149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized: Fatty acid desaturase (FADS2) mRNA

<400>  7
agggggcgcg gtgggaggag taggagaaga caaaagccga aagcgaagag ggcccgggct       60

gcacacaccg gctgggaggc agccgtctgt gcagcgagca gccggcgcgg ggaggccgca      120

gtgcacgggg cgtcacagtc ggcaggcagc atggggaagg gagggaacca gggcgagggg      180

gccgccgagc gcgaggtgtc ggtgcccacc ttcagctggg aggagattca gaagcataac      240

ctgcgcaccg acaggtggct ggtcattgac cgcaaggttt acaacatcac caaatggtcc      300

atccagcacc cggggggcca gcgggtcatc gggcactacg ctggagaaga tgcaacggat      360

gccttccgcg ccttccaccc tgacctggaa ttcgtgggca agttcttgaa acccctgctg      420

attggtgaac tggccccgga ggagcccagc caggaccacg gcaagaactc aaagatcact      480

gaggacttcc gggccctgag gaagacggct gaggacatga acctgttcaa gaccaaccac      540

gtgttcttcc tcctcctcct ggcccacatc atcgccctgg agagcattgc atggttcact      600

gtcttttact ttggcaatgg ctggattcct accctcatca cggcctttgt ccttgctacc      660

tctcaggccc aagctggatg gctgcaacat gattatggcc acctgtctgt ctacagaaaa      720

cccaagtgga accaccttgt ccacaaattc gtcattggcc acttaaaggg tgcctctgcc      780

aactggtgga atcatcgcca cttccagcac cacgccaagc ctaacatctt ccacaaggat      840

cccgatgtga acatgctgca cgtgtttgtt ctgggcgaat ggcagcccat cgagtacggc      900

aagaagaagc tgaaatacct gccctacaat caccagcacg aatacttctt cctgattggg      960

ccgccgctgc tcatccccat gtatttccag taccagatca tcatgaccat gatcgtccat     1020

aagaactggg tggacctggc ctgggccgtc agctactaca tccggttctt catcacctac     1080

atccctttct acggcatcct gggagccctc cttttcctca acttcatcag gttcctggag     1140

agccactggt ttgtgtgggt cacacagatg aatcacatcg tcatggagat tgaccaggag     1200

gcctaccgtg actggttcag tagccagctg acagccacct gcaacgtgga gcagtccttc     1260

ttcaacgact ggttcagtgg acaccttaac ttccagattg agcaccacct cttccccacc     1320

atgccccggc acaacttaca caagatcgcc ccgctggtga agtctctatg tgccaagcat     1380

ggcattgaat accaggagaa gccgctactg agggccctgc tggacatcat caggtccctg     1440

aagaagtctg ggaagctgtg gctggacgcc taccttcaca aatgaagcca cagcccccgg     1500

gacaccgtgg ggaaggggtg caggtggggt gatggccaga ggaatgatgg gcttttgttc     1560

tgaggggtgt ccgagaggct ggtgtatgca ctgctcacgg accccatgtt ggatctttct     1620

ccctttctcc tctccttttt ctcttcacat ctcccccata gcaccctgcc ctcatgggac     1680

ctgccctccc tcagccgtca gccatcagcc atggccctcc cagtgcctcc tagccccttc     1740

ttccaaggag cagagaggtg gccaccgggg gtggctctgt cctacctcca ctctctgccc     1800

ctaaagatgg gaggagacca gcggtccatg ggtctggcct gtgagtctcc ccttgcagcc     1860

tggtcactag gcatcacccc cgctttggtt cttcagatgc tcttggggtt cataggggca     1920

ggtcctagtc gggcagggcc cctgaccctc ccggcctggc ttcactctcc ctgacggctg     1980

ccattggtcc accctttcat agagaggcct gctttgttac aaagctcggg tctccctcct     2040

gcagctcggt taagtacccg aggcctctct taagatgtcc agggccccag gcccgcgggc     2100

acagccagcc caaaccttgg gccctggaag agtcctccac cccatcacta gagtgctctg     2160

accctgggct ttcacgggcc ccattccacc gcctccccaa cttgagcctg tgaccttggg     2220

accaaagggg gagtccctcg tctcttgtga ctcagcagag gcagtggcca cgttcaggga     2280

ggggccggct ggcctggagg ctcagcccac cctccagctt ttcctcaggg tgtcctgagg     2340

tccaagattc tggagcaatc tgacccttct ccaaaggctc tgttatcagc tgggcagtgc     2400

cagccaatcc ctggccattt ggccccaggg gacgtgggcc ctgcaggctg caggagggca     2460

ctggagctgg gaggtctcgt cccagccctc cccatctcgg ggctgctgtg tggacggcgc     2520

tgcctcaggc actctcctgt ctgaacctgc ccttactgtg tttaacctgt tgctccagga     2580

tgcattctga taggaggggg cggcagggct gggccttgtg acaatctgcc tttcaccaca     2640

tggccttgcc tcggtggccc tgactgtcag ggagggccag ggaggcagag cgggagggag     2700

tctcaggagg aggctgccct gaggggctgg ggagggggta cctcatgagg accagggtgg     2760

agctgagaag aggaggaggt gggggctgga ggtgctggta gctgagggga cgggcaagtg     2820

agaggggagg gagggaagtc ctgggaggat cctgagctgc tgttgcagtc taacccacta     2880

atcagttctt agattcaggg gaagggcagg caccaacaac tcagaatggg ggctttcggg     2940

gagggcgcct agtcccccca gctctaagca gccaggaggg acctgcatct aagcatctgg     3000

gttgccatgg caatggcatg ccccccagct actgtatgcc cccgaccccc gcagaggcag     3060

aatgaaccca tagggagctg atcgtaatgt ttatcatgtt acttccccac ccctacattt     3120

tttgaaataa aataaggaat tttattctc                                       3149


<210>  8
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized: Fatty acid desaturase (FADS2) protein

<400>  8

Met Gly Lys Gly Gly Asn Gln Gly Glu Gly Ala Ala Glu Arg Glu Val 
1               5                   10                  15      


Ser Val Pro Thr Phe Ser Trp Glu Glu Ile Gln Lys His Asn Leu Arg 
            20                  25                  30          


Thr Asp Arg Trp Leu Val Ile Asp Arg Lys Val Tyr Asn Ile Thr Lys 
        35                  40                  45              


Trp Ser Ile Gln His Pro Gly Gly Gln Arg Val Ile Gly His Tyr Ala 
    50                  55                  60                  


Gly Glu Asp Ala Thr Asp Ala Phe Arg Ala Phe His Pro Asp Leu Glu 
65                  70                  75                  80  


Phe Val Gly Lys Phe Leu Lys Pro Leu Leu Ile Gly Glu Leu Ala Pro 
                85                  90                  95      


Glu Glu Pro Ser Gln Asp His Gly Lys Asn Ser Lys Ile Thr Glu Asp 
            100                 105                 110         


Phe Arg Ala Leu Arg Lys Thr Ala Glu Asp Met Asn Leu Phe Lys Thr 
        115                 120                 125             


Asn His Val Phe Phe Leu Leu Leu Leu Ala His Ile Ile Ala Leu Glu 
    130                 135                 140                 


Ser Ile Ala Trp Phe Thr Val Phe Tyr Phe Gly Asn Gly Trp Ile Pro 
145                 150                 155                 160 


Thr Leu Ile Thr Ala Phe Val Leu Ala Thr Ser Gln Ala Gln Ala Gly 
                165                 170                 175     


Trp Leu Gln His Asp Tyr Gly His Leu Ser Val Tyr Arg Lys Pro Lys 
            180                 185                 190         


Trp Asn His Leu Val His Lys Phe Val Ile Gly His Leu Lys Gly Ala 
        195                 200                 205             


Ser Ala Asn Trp Trp Asn His Arg His Phe Gln His His Ala Lys Pro 
    210                 215                 220                 


Asn Ile Phe His Lys Asp Pro Asp Val Asn Met Leu His Val Phe Val 
225                 230                 235                 240 


Leu Gly Glu Trp Gln Pro Ile Glu Tyr Gly Lys Lys Lys Leu Lys Tyr 
                245                 250                 255     


Leu Pro Tyr Asn His Gln His Glu Tyr Phe Phe Leu Ile Gly Pro Pro 
            260                 265                 270         


Leu Leu Ile Pro Met Tyr Phe Gln Tyr Gln Ile Ile Met Thr Met Ile 
        275                 280                 285             


Val His Lys Asn Trp Val Asp Leu Ala Trp Ala Val Ser Tyr Tyr Ile 
    290                 295                 300                 


Arg Phe Phe Ile Thr Tyr Ile Pro Phe Tyr Gly Ile Leu Gly Ala Leu 
305                 310                 315                 320 


Leu Phe Leu Asn Phe Ile Arg Phe Leu Glu Ser His Trp Phe Val Trp 
                325                 330                 335     


Val Thr Gln Met Asn His Ile Val Met Glu Ile Asp Gln Glu Ala Tyr 
            340                 345                 350         


Arg Asp Trp Phe Ser Ser Gln Leu Thr Ala Thr Cys Asn Val Glu Gln 
        355                 360                 365             


Ser Phe Phe Asn Asp Trp Phe Ser Gly His Leu Asn Phe Gln Ile Glu 
    370                 375                 380                 


His His Leu Phe Pro Thr Met Pro Arg His Asn Leu His Lys Ile Ala 
385                 390                 395                 400 


Pro Leu Val Lys Ser Leu Cys Ala Lys His Gly Ile Glu Tyr Gln Glu 
                405                 410                 415     


Lys Pro Leu Leu Arg Ala Leu Leu Asp Ile Ile Arg Ser Leu Lys Lys 
            420                 425                 430         


Ser Gly Lys Leu Trp Leu Asp Ala Tyr Leu His Lys 
        435                 440                 


<210>  9
<211>  2477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized: Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) mRNA

<400>  9
ataaagtcct gccgggcacc actgggcatc tctttcaagg tttctgctgg gtttctgaac       60

tgctgggttt ctgcttgctc ctctggagat gcagcgtctg ttgactccag tgaagcgcat      120

tctgcaactg acaagagcgg tgcaggaaac ctccctcaca cctgctcgcc tgctcccagt      180

agcccaccaa aggttttcta cagcctctgc tgtccccctg gccaaaacag atacttggcc      240

aaaggacgtg ggcatcctgg ccctggaggt ctacttccca gcccaatatg tggaccaaac      300

tgacctggag aagtataaca atgtggaagc aggaaagtat acagtgggct tgggccagac      360

ccgtatgggc ttctgctcag tccaagagga catcaactcc ctgtgcctga cggtggtgca      420

acggctgatg gagcgcatac agctcccatg ggactctgtg ggcaggctgg aagtaggcac      480

tgagaccatc attgacaagt ccaaagctgt caaaacagtg ctcatggaac tcttccagga      540

ttcaggcaat actgatattg agggcataga taccaccaat gcctgctacg gtggtactgc      600

ctccctcttc aatgctgcca actggatgga gtccagttcc tgggatggtc gttatgccat      660

ggtggtctgt ggagacattg ccgtctatcc cagtggtaat gctcgtccca caggtggggc      720

cggagctgtg gctatgctga ttgggcccaa ggcccctctg gccctggagc gagggctgag      780

gggaacccat atggagaatg tgtatgactt ctacaaacca aatttggcct cggagtaccc      840

aatagtggat gggaagcttt ccatccagtg ctacttgcgg gccttggatc gatgttacac      900

atcataccgt aaaaaaatcc agaatcagtg gaagcaagct ggcagcgatc gacccttcac      960

ccttgacgat ttacagtaca tgatctttca tacacccttt tgcaagatgg tccagaagtc     1020

tctggctcgc ctgatgttca atgacttcct gtcagccagc agtgacacac aaaccagctt     1080

atataagggg ctggaggctt tcggggggct aaagctggaa gacacctaca ccaacaagga     1140

cctggataaa gcacttctaa aggcctctca ggacatgttc gacaagaaaa ccaaggcttc     1200

cctttacctc tccactcaca atgggaacat gtacacctca tccctgtacg ggtgcctggc     1260

ctcgcttctg tcccaccact ctgcccaaga actggctggc tccaggattg gtgccttctc     1320

ttatggctct ggtttagcag caagtttctt ttcatttcga gtatcccagg atgctgctcc     1380

aggctctccc ctggacaagt tggtgtccag cacatcagac ctgccaaaac gcctagcctc     1440

ccgaaagtgt gtgtctcctg aggagttcac agaaataatg aaccaaagag agcaattcta     1500

ccataaggtg aatttctccc cacctggtga cacaaacagc cttttcccag gtacttggta     1560

cctggagcga gtggacgagc agcatcgccg aaagtatgcc cggcgtcccg tctaaaggtg     1620

ttctgcagat ccatggaaag cttcctggga aacgtatgct agcagagctt ctccccgtga     1680

atcatatttt taagatccca ctcttagctg gtaaatgaat ttgaatcgac atagtagccc     1740

cataagcatc agccctgtag agtgaggagc catctctagc gggcccttca ttcctctcca     1800

tgctgcaatc actgtcctgg gcttatggtg ctatggacta ggggtccttt gtgaaagagc     1860

aagatggagc aatggagaga agacctcttc ctgaatcact ggactccaga aatgtgcatg     1920

cagatcagct gttgccttca agatccagat aaactttcct gtcatgtgtt agaactttat     1980

tattattaat attgttaaac ttctgtgctg ttcctgtgaa tctccaaatt ttgtaccttg     2040

ttctaagcta atatatagca attaaaaaga gagaaagagg aaatgattcc tgcgtttctt     2100

ggaacccaga atacaaaccc agcctaacat gcagcaagcc tgctagacct tgtgggtcag     2160

agggctgggt ccttgcctca caggctgcct ctgtcccctt gcaattccat tctatttctg     2220

ccacatgcca agtgctatga caggtacaag gcaaataaga acggtagaac acagcttccc     2280

ccagcccact tccctgttct aaagacacca catagacaga gagcagcaga caggggccag     2340

caggagctgt agttcagatc ttcttggtca ttccttgccg ctgttatttg aacaaataaa     2400

cacagcgcaa aggttaacaa gtttttgcct tctatagcca aaaataaaaa aataaataaa     2460

ttttgaaaaa aaaaaaa                                                    2477


<210>  10
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized: Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) 
       protein

<400>  10

Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
1               5                   10                  15      


Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
            20                  25                  30          


His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp 
        35                  40                  45              


Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  


Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu 
65                  70                  75                  80  


Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                85                  90                  95      


Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         


Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu 
        115                 120                 125             


Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
    130                 135                 140                 


Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 


Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     


Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val 
            180                 185                 190         


Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr 
        195                 200                 205             


Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
    210                 215                 220                 


Ala Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp 
225                 230                 235                 240 


Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys 
                245                 250                 255     


Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser 
            260                 265                 270         


Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg 
        275                 280                 285             


Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe 
    290                 295                 300                 


Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
305                 310                 315                 320 


Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu 
                325                 330                 335     


Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu 
            340                 345                 350         


Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr 
        355                 360                 365             


Lys Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser 
    370                 375                 380                 


Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
385                 390                 395                 400 


Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                405                 410                 415     


Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly 
            420                 425                 430         


Ser Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg 
        435                 440                 445             


Leu Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met 
    450                 455                 460                 


Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
465                 470                 475                 480 


Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                485                 490                 495     


Glu Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
            500                 505             


<210>  11
<211>  4589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized: Hydroxymethylglutaryl-CoA reductase (HMGCR) mRNA

<400>  11
ctcttattgg tcgaaggctc gtccagctcc gagcgtgcgt aaggtgaggg ctccttccgc       60

tccgcgactg cgttaactgg agccaggctg agcgtcggcg ccggggttcg gtggcctcta      120

gtgagatctg gaggatccaa ggattctgta gctacaatgt tgtcaagact ttttcgaatg      180

catggcctct ttgtggcctc ccatccctgg gaagtcatag tggggacagt gacactgacc      240

atctgcatga tgtccatgaa catgtttact ggtaacaata agatctgtgg ttggaattat      300

gaatgtccaa agtttgaaga ggatgttttg agcagtgaca ttataattct gacaataaca      360

cgatgcatag ccatcctgta tatttacttc cagttccaga atttacgtca acttggatca      420

aaatatattt tgggtattgc tggccttttc acaattttct caagttttgt attcagtaca      480

gttgtcattc acttcttaga caaagaattg acaggcttga atgaagcttt gccctttttc      540

ctacttttga ttgacctttc cagagcaagc acattagcaa agtttgccct cagttccaac      600

tcacaggatg aagtaaggga aaatattgct cgtggaatgg caattttagg tcctacgttt      660

accctcgatg ctcttgttga atgtcttgtg attggagttg gtaccatgtc aggggtacgt      720

cagcttgaaa ttatgtgctg ctttggctgc atgtcagttc ttgccaacta cttcgtgttc      780

atgactttct tcccagcttg tgtgtccttg gtattagagc tttctcggga aagccgcgag      840

ggtcgtccaa tttggcagct cagccatttt gcccgagttt tagaagaaga agaaaataag      900

ccgaatcctg taactcagag ggtcaagatg attatgtctc taggcttggt tcttgttcat      960

gctcacagtc gctggatagc tgatccttct cctcaaaaca gtacagcaga tacttctaag     1020

gtttcattag gactggatga aaatgtgtcc aagagaattg aaccaagtgt ttccctctgg     1080

cagttttatc tctctaaaat gatcagcatg gatattgaac aagttattac cctaagttta     1140

gctctccttc tggctgtcaa gtacatcttc tttgaacaaa cagagacaga atctacactc     1200

tcattaaaaa accctatcac atctcctgta gtgacacaaa agaaagtccc agacaattgt     1260

tgtagacgtg aacctatgct ggtcagaaat aaccagaaat gtgattcagt agaggaagag     1320

acagggataa accgagaaag aaaagttgag gttataaaac ccttagtggc tgaaacagat     1380

accccaaaca gagctacatt tgtggttggt aactcctcct tactcgatac ttcatcagta     1440

ctggtgacac aggaacctga aattgaactt cccagggaac ctcggcctaa tgaagaatgt     1500

ctacagatac ttgggaatgc agagaaaggt gcaaaattcc ttagtgatgc tgagatcatc     1560

cagttagtca atgctaagca tatcccagcc tacaagttgg aaactctgat ggaaactcat     1620

gagcgtggtg tatctattcg ccgacagtta ctttccaaga agctttcaga accttcttct     1680

ctccagtacc taccttacag ggattataat tactccttgg tgatgggagc ttgttgtgag     1740

aatgttattg gatatatgcc catccctgtt ggagtggcag gacccctttg cttagatgaa     1800

aaagaatttc aggttccaat ggcaacaaca gaaggttgtc ttgtggccag caccaataga     1860

ggctgcagag caataggtct tggtggaggt gccagcagcc gagtccttgc agatgggatg     1920

actcgtggcc cagttgtgcg tcttccacgt gcttgtgact ctgcagaagt gaaagcctgg     1980

ctcgaaacat ctgaagggtt cgcagtgata aaggaggcat ttgacagcac tagcagattt     2040

gcacgtctac agaaacttca tacaagtata gctggacgca acctttatat ccgtttccag     2100

tccaggtcag gggatgccat ggggatgaac atgatttcaa agggtacaga gaaagcactt     2160

tcaaaacttc acgagtattt ccctgaaatg cagattctag ccgttagtgg taactattgt     2220

actgacaaga aacctgctgc tataaattgg atagagggaa gaggaaaatc tgttgtttgt     2280

gaagctgtca ttccagccaa ggttgtcaga gaagtattaa agactaccac agaggctatg     2340

attgaggtca acattaacaa gaatttagtg ggctctgcca tggctgggag cataggaggc     2400

tacaacgccc atgcagcaaa cattgtcacc gccatctaca ttgcctgtgg acaggatgca     2460

gcacagaatg ttggtagttc aaactgtatt actttaatgg aagcaagtgg tcccacaaat     2520

gaagatttat atatcagctg caccatgcca tctatagaga taggaacggt gggtggtggg     2580

accaacctac tacctcagca agcctgtttg cagatgctag gtgttcaagg agcatgcaaa     2640

gataatcctg gggaaaatgc ccggcagctt gcccgaattg tgtgtgggac cgtaatggct     2700

ggggaattgt cacttatggc agcattggca gcaggacatc ttgtcaaaag tcacatgatt     2760

cacaacaggt cgaagatcaa tttacaagac ctccaaggag cttgcaccaa gaagacagcc     2820

tgaatagccc gacagttctg aactggaaca tgggcattgg gttctaaagg actaacataa     2880

aatctgtgaa ttaaaaaagc tcaatgcatt gtcttgtgga ggatgaatag atgtgatcac     2940

tgagacagcc acttggtttt tggctctttc agagaggtct caggttcttt ccatgcagac     3000

tcctcagatc tgaacacagt ttagtgcttt acatgctgtg ctctttgaag agatttcaac     3060

aagaatattg tatgttaaag catcagagat ggtaatctac agctcacctc tgaaggcaaa     3120

tataagctgg gaaaaaagtt ttgatgaaat tcttgaagtt catggtgatc agtgcaattg     3180

accttctccc tcactcctgc cagttgaaaa tggattttta aattatactg tagctgatga     3240

aactcctgat tttgtagtta atttattaag tctgggatgt agaacttcaa gaagtaagag     3300

ctaagttcta agttcatgtt tgtaaattaa tacttcattt ggtgctggtc tattttgatt     3360

ttggggggta atcagcatta ttcttcagaa ggggacctgt tttcttcaag ggaagaaaca     3420

ctcttattcc caaactacag aataatgtgt taaacatgct aaatagttct atcaggaaaa     3480

caaatcactg tatttatctc cgcaggctat ttgttcagag aggccttttg tttaaatata     3540

aatgtttaaa tataaatgtt tgtctggatt ggctataaca tgtctttcag cattaggctt     3600

ttaagaaaca cagggttttg tattctttac taaagatatc agagctctta atgttgctta     3660

gatgagggtg actgtcaagt acaagcaaga ctgggacctt agaaatcatt gtagaaacac     3720

agttttgaaa gaaaaatacc atgtctctaa gccaacttta attgcttaaa agacattttt     3780

atttagttga aaaatctagt tttttttgta aactgtatca aatctgtata tgttgtaata     3840

aaacttatgc tagtttattg gaagtgttca agaaataaaa atcaacttgt gtactgataa     3900

aatactctag cctgggccag agaagataat gttctttaat gttgtccagg aaaccctggc     3960

ttgcttgccg agcctaatga aagggaaagt cagctttcag agccagtgaa ggagccacgt     4020

gaatggccct agaactgtgc ctagttcctg tggccaggag gttggtgact gaaacattca     4080

cacagggctc tttgatggac ccacgaacgc tcttagcttt ctcagggggt cagcagagtt     4140

attgaatctt aatttttttt aatgtacaag ttttgtataa ataataaaga actccttatt     4200

ttgtattaca tctaatgctt caagtgttgc tcttggaaag ctgatgatgt ctcttgtaga     4260

agatggactc tgaaaaacat tccaggaaac catggcagca tggagagcct cttagtgatt     4320

gtgtctgcat tgttattgtg gaagatttac cttttctgtt gtacgtaaag cttaaattgc     4380

ttttgttgtg actttttagc cagtgacttt ttctgagctt ttcatggaag tggcagtgaa     4440

aaatatgttg agtgttcatt ttagtgactg taattaatat cttgctggat taatgttttg     4500

tacaattact aaattgtata cattttgtta tagaatactt ttttctagtt tcagtaaata     4560

atgaaaagga agttaatacc aaaaaaaaa                                       4589


<210>  12
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized: Hydroxymethylglutaryl-CoA reductase (HMGCR) protein

<400>  12

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
            20                  25                  30          


Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
        35                  40                  45              


Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
    50                  55                  60                  


Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
65                  70                  75                  80  


Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                85                  90                  95      


Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
            100                 105                 110         


Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
        115                 120                 125             


Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
    130                 135                 140                 


Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
145                 150                 155                 160 


Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                165                 170                 175     


Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
            180                 185                 190         


Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
        195                 200                 205             


Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
    210                 215                 220                 


Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
225                 230                 235                 240 


Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                245                 250                 255     


Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
            260                 265                 270         


Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
    290                 295                 300                 


Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
305                 310                 315                 320 


Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                325                 330                 335     


Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
            340                 345                 350         


Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
        355                 360                 365             


Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
    370                 375                 380                 


Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
385                 390                 395                 400 


Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                405                 410                 415     


Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
            420                 425                 430         


Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
        435                 440                 445             


Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
    450                 455                 460                 


Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
465                 470                 475                 480 


Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                485                 490                 495     


Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
            500                 505                 510         


Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
        515                 520                 525             


Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
    530                 535                 540                 


Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
545                 550                 555                 560 


Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                565                 570                 575     


Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
            580                 585                 590         


Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
        595                 600                 605             


Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
    610                 615                 620                 


Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
625                 630                 635                 640 


Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                645                 650                 655     


Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
            660                 665                 670         


Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
        675                 680                 685             


Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
    690                 695                 700                 


Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
705                 710                 715                 720 


Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                725                 730                 735     


Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
            740                 745                 750         


Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
        755                 760                 765             


Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
    770                 775                 780                 


Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
785                 790                 795                 800 


Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                805                 810                 815     


Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
            820                 825                 830         


Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
        835                 840                 845             


Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
    850                 855                 860                 


Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
865                 870                 875                 880 


Gly Ala Cys Thr Lys Lys Thr Ala 
                885             


