                         SEQUENCE LISTING

<110>  Nationwide Children's Hospital
       Ludwig Institute for Cancer Research
       Kaspar, et al.
 
<120>  PRODUCTS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL 
       SCLEROSIS

<130>  28335/47886PCT

<150>  US 61/870585
<151>  2013-08-27

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
gcatcatcaa tttcgagcag aaggaa                                            26


<210>  2
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  2
gaagcattaa aggactgact gaa                                               23


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
ctgactgaag gcctgcatgg att                                               23


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
catggattcc atgttcatga                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
gcatggattc catgttcatg a                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
ggtctggcct ataaagtagt c                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
gggcatcatc aatttcgagc a                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
gcatcatcaa tttcgagcag a                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
gcctgcatgg attccatgtt c                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
ggaggtctgg cctataaagt a                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
gattccatgt tcatgagttt g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
ggagataata cagcaggctg t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
gctttaaagt acctgtagtg a                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
gcattaaagg actgactgaa g                                                 21


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
tcatcaattt cgagcagaa                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
tcgagcagaa ggaaagtaa                                                    19


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
gcctgcatgg attccatgt                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
tcactctcag gagaccatt                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
gctttaaagt acctgtagt                                                    19


<210>  20
<211>  5786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctgattct       60

aacgaggaaa gcacgttata cgtgctcgtc aaagcaacca tagtacgcgc cctgtagcgg      120

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc      180

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc      240

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct      300

cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac      360

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac      420

tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat      480

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa      540

aatattaacg cttacaattt aaatatttgc ttatacaatc ttcctgtttt tggggctttt      600

ctgattatca accggggtac atatgattga catgctagtt ttacgattac cgttcatcgc      660

cctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt      720

tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggaat tcacgcgtgg      780

atctgaattc aattcacgcg tggtacctac actttatgct tccggctcgt atgttgtgtg      840

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc      900

tttccaaaaa agcatggatt ccatgttcat gatctcttga atcatgaaca tggaatccat      960

ggatccgagt ggtctcatac agaacttata agattcccaa atccaaagac atttcacgtt     1020

tatggtgatt tcccagaaca catagcgaca tgcaaatatg aattcactgg ccgtcgtttt     1080

acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc     1140

ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt     1200

gcgcagcctg tggtacctct ggtcgttaca taacttacgg taaatggccc gcctggctga     1260

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca     1320

atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca     1380

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg     1440

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc     1500

tactcgaggc cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt     1560

tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc     1620

gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg     1680

cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc     1740

ggcggcccta taaaaagcga agcgcgcggc gggcgggagc gggatcagcc accgcggtgg     1800

cggcctagag tcgacgagga actgaaaaac cagaaagtta actggtaagt ttagtctttt     1860

tgtcttttat ttcaggtccc ggatccggtg gtggtgcaaa tcaaagaact gctcctcagt     1920

ggatgttgcc tttacttcta ggcctgtacg gaagtgttac ttctgctcta aaagctgcgg     1980

aattgtaccc gcggccgatc caccggtcgc caccatggtg agcaagggcg aggagctgtt     2040

caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag     2100

cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg     2160

caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt     2220

gcagtgcttc agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat     2280

gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac     2340

ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat     2400

cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca     2460

caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg     2520

ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat     2580

cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag     2640

caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg     2700

gatcactctc ggcatggacg agctgtacaa gtaaagcggc catcaagctt atcgataccg     2760

tcgactagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt     2820

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     2880

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     2940

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggagaga     3000

tcgatctgag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     3060

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     3120

gagcgagcga gcgcgcagag agggagtggc cccccccccc ccccccccgg cgattctctt     3180

gtttgctcca gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag     3240

ctaccctctc cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt     3300

tgactgtctc cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg     3360

catttaaaat atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc     3420

ccgcaaaagt attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg     3480

aggctttatt gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg     3540

gaatcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg     3600

gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc     3660

aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc     3720

tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc     3780

gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt     3840

ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt     3900

tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca     3960

ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt     4020

ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga     4080

tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa     4140

gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct     4200

gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat     4260

acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga     4320

tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc     4380

caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat     4440

gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa     4500

cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac     4560

tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa     4620

agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc     4680

tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc     4740

ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag     4800

acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta     4860

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa     4920

gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc     4980

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat     5040

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga     5100

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt     5160

ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata     5220

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac     5280

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg     5340

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg     5400

tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag     5460

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct     5520

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc     5580

aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt     5640

ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg     5700

tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga     5760

gtcagtgagc gaggaagcgg aagagc                                          5786


<210>  21
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
aattcatatt tgcatgtcgc tatgtgttct gggaaatcac cataaacgtg aaatgtcttt       60

ggatttggga atcttataag ttctgtatga gaccactcgg atccatggat tccatgttca      120

tgattcaaga gatcatgaac atggaatcca tgcttttttg gaaa                       164


<210>  22
<211>  1607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
tctagaggct cgagaagata tcaactgcag cttctactgg gcggttttat ggacagcaag       60

cgaaccggaa ttgccagctg gggcgccctc tggtaaggtt gggaagccct gcaaagtaaa      120

ctggatggct ttctcgccgc caaggatctg atggcgcagg ggatcaagct ctgatcaaga      180

gacaggatga ggatcgtttc gcgttcttga ctcttcgcga tgtacgggcc agatatacgc      240

gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata      300

gcccatatat ggagttccgc ctgcagggac gtcgacggat cgggagatct cccgatcccc      360

tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt gcgcgagcaa aatttaagct      420

acaacaaggc aaggcttgac cgacaattgc atgaagaatc tgcttagggt taggcgtttt      480

gcgctgcttc gcggcgcgcc ttttaaggca gttattggtg cccttaaacg cctggtgcta      540

cgcctgaata agtgataata agcggatgaa tggcagaaat tcgccggatc tttgtgaagg      600

aaccttactt ctgtggtgtg acataattgg acaaactacc tacagagatt taaagctcta      660

atgtaagcag acagttttat tgttcatgat gatatatttt tatcttgtgc aatgtaacat      720

cagagatttt gagacacaac gtggctttcc cccccccccc ctagggtggg cgaagaactc      780

cagcatgaga tccccgcgct ggaggatcat ccagccggcg tcccggaaaa cgattccgaa      840

gcccaacctt tcatagaagg cggcggtgga atcgaaatct cgtgatggca ggttgggcgt      900

cgcttggtcg gtcatttcga accccagagt cccgctcagg gcgcgccggg ggggggggcg      960

ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac caggcctgaa tcgccccatc     1020

atccagccag aaagtgaggg agccacggtt gatgagagct ttgttgtagg tggaccagtc     1080

ctgcaggagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     1140

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgcccgc ccagtctagc     1200

tatcgccatg taagcccact gcaagctacc tgctttctct ttgcgcttgc gttttccctt     1260

gtccagatag cccagtagct gacattcatc cggggtcagc accgtttctg cggactggct     1320

ttctacgtgt ctggttcgag gcgggatcag ccaccgcggt ggcggcctag agtcgacgag     1380

gaactgaaaa accagaaagt taactggcct gtacggaagt gttacttctg ctctaaaagc     1440

tgcggaattg tacccgcggc cgatccaccg gtcgccacca gcggccatca agcacgttat     1500

cgataccgtc gactagagct cgctgatcag tggggggtgg ggtggggcag gacagcaagg     1560

gggaggattg ggaagacaat agcagctgca gaagtttaaa cgcatgc                   1607


