
                                SEQUENCE LISTING

<110> INVISTA North America S.a r.l.

<120> METHODS FOR BIOSYNTHESIZING METHACRYLATE
  

<130> 35643-0047WO1

<150> US 61/871,070       
<151> 2013-08-28  

<160> 9

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 286
<212> PRT
<213> Escherichia coli

<400> 1
Met Ser Gln Ala Leu Lys Asn Leu Leu Thr Leu Leu Asn Leu Glu Lys
 1               5                  10                  15      
Ile Glu Glu Gly Leu Phe Arg Gly Gln Ser Glu Asp Leu Gly Leu Arg
            20                  25                  30          
Gln Val Phe Gly Gly Gln Val Val Gly Gln Ala Leu Tyr Ala Ala Lys
        35                  40                  45              
Glu Thr Val Pro Glu Glu Arg Leu Val His Ser Phe His Ser Tyr Phe
    50                  55                  60                  
Leu Arg Pro Gly Asp Ser Lys Lys Pro Ile Ile Tyr Asp Val Glu Thr
65                  70                  75                  80  
Leu Arg Asp Gly Asn Ser Phe Ser Ala Arg Arg Val Ala Ala Ile Gln
                85                  90                  95      
Asn Gly Lys Pro Ile Phe Tyr Met Thr Ala Ser Phe Gln Ala Pro Glu
            100                 105                 110         
Ala Gly Phe Glu His Gln Lys Thr Met Pro Ser Ala Pro Ala Pro Asp
        115                 120                 125             
Gly Leu Pro Ser Glu Thr Gln Ile Ala Gln Ser Leu Ala His Leu Leu
    130                 135                 140                 
Pro Pro Val Leu Lys Asp Lys Phe Ile Cys Asp Arg Pro Leu Glu Val
145                 150                 155                 160 
Arg Pro Val Glu Phe His Asn Pro Leu Lys Gly His Val Ala Glu Pro
                165                 170                 175     
His Arg Gln Val Trp Ile Arg Ala Asn Gly Ser Val Pro Asp Asp Leu
            180                 185                 190         
Arg Val His Gln Tyr Leu Leu Gly Tyr Ala Ser Asp Leu Asn Phe Leu
        195                 200                 205             
Pro Val Ala Leu Gln Pro His Gly Ile Gly Phe Leu Glu Pro Gly Ile
    210                 215                 220                 
Gln Ile Ala Thr Ile Asp His Ser Met Trp Phe His Arg Pro Phe Asn
225                 230                 235                 240 
Leu Asn Glu Trp Leu Leu Tyr Ser Val Glu Ser Thr Ser Ala Ser Ser
                245                 250                 255     
Ala Arg Gly Phe Val Arg Gly Glu Phe Tyr Thr Gln Asp Gly Val Leu
            260                 265                 270         
Val Ala Ser Thr Val Gln Glu Gly Val Met Arg Asn His Asn
        275                 280                 285     


<210> 2
<211> 132
<212> PRT
<213> Escherichia coli

<400> 2
Met Ser Thr Thr His Asn Val Pro Gln Gly Asp Leu Val Leu Arg Thr
 1               5                  10                  15      
Leu Ala Met Pro Ala Asp Thr Asn Ala Asn Gly Asp Ile Phe Gly Gly
            20                  25                  30          
Trp Leu Met Ser Gln Met Asp Ile Gly Gly Ala Ile Leu Ala Lys Glu
        35                  40                  45              
Ile Ala His Gly Arg Val Val Thr Val Arg Val Glu Gly Met Thr Phe
    50                  55                  60                  
Leu Arg Pro Val Ala Val Gly Asp Val Val Cys Cys Tyr Ala Arg Cys
65                  70                  75                  80  
Val Gln Lys Gly Thr Thr Ser Val Ser Ile Asn Ile Glu Val Trp Val
                85                  90                  95      
Lys Lys Val Ala Ser Glu Pro Ile Gly Gln Arg Tyr Lys Ala Thr Glu
            100                 105                 110         
Ala Leu Phe Lys Tyr Val Ala Val Asp Pro Glu Gly Lys Pro Arg Ala
        115                 120                 125             
Leu Pro Val Glu
    130         


<210> 3
<211> 154
<212> PRT
<213> Haemophilus influenzae

<400> 3
Met Ser Ala Asn Phe Thr Asp Lys Asn Gly Arg Gln Ser Lys Gly Val
 1               5                  10                  15      
Leu Leu Leu Arg Thr Leu Ala Met Pro Ser Asp Thr Asn Ala Asn Gly
            20                  25                  30          
Asp Ile Phe Gly Gly Trp Ile Met Ser Gln Met Asp Met Gly Gly Ala
        35                  40                  45              
Ile Leu Ala Lys Glu Ile Ala His Gly Arg Val Val Thr Val Ala Val
    50                  55                  60                  
Glu Ser Met Asn Phe Ile Lys Pro Ile Ser Val Gly Asp Val Val Cys
65                  70                  75                  80  
Cys Tyr Gly Gln Cys Leu Lys Val Gly Arg Ser Ser Ile Lys Ile Lys
                85                  90                  95      
Val Glu Val Trp Val Lys Lys Val Ala Ser Glu Pro Ile Gly Glu Arg
            100                 105                 110         
Tyr Cys Val Thr Asp Ala Val Phe Thr Phe Val Ala Val Asp Asn Asn
        115                 120                 125             
Gly Arg Ser Arg Thr Ile Pro Arg Glu Asn Asn Gln Glu Leu Glu Lys
    130                 135                 140                 
Ala Leu Thr Leu Ile Ser Glu Gln Pro Leu
145                 150                 


<210> 4
<211> 524
<212> PRT
<213> Clostridium propionicum

<400> 4
Met Arg Lys Val Pro Ile Ile Thr Ala Asp Glu Ala Ala Lys Leu Ile
 1               5                  10                  15      
Lys Asp Gly Asp Thr Val Thr Thr Ser Gly Phe Val Gly Asn Ala Ile
            20                  25                  30          
Pro Glu Ala Leu Asp Arg Ala Val Glu Lys Arg Phe Leu Glu Thr Gly
        35                  40                  45              
Glu Pro Lys Asn Ile Thr Tyr Val Tyr Cys Gly Ser Gln Gly Asn Arg
    50                  55                  60                  
Asp Gly Arg Gly Ala Glu His Phe Ala His Glu Gly Leu Leu Lys Arg
65                  70                  75                  80  
Tyr Ile Ala Gly His Trp Ala Thr Val Pro Ala Leu Gly Lys Met Ala
                85                  90                  95      
Met Glu Asn Lys Met Glu Ala Tyr Asn Val Ser Gln Gly Ala Leu Cys
            100                 105                 110         
His Leu Phe Arg Asp Ile Ala Ser His Lys Pro Gly Val Phe Thr Lys
        115                 120                 125             
Val Gly Ile Gly Thr Phe Ile Asp Pro Arg Asn Gly Gly Gly Lys Val
    130                 135                 140                 
Asn Asp Ile Thr Lys Glu Asp Ile Val Glu Leu Val Glu Ile Lys Gly
145                 150                 155                 160 
Gln Glu Tyr Leu Phe Tyr Pro Ala Phe Pro Ile His Val Ala Leu Ile
                165                 170                 175     
Arg Gly Thr Tyr Ala Asp Glu Ser Gly Asn Ile Thr Phe Glu Lys Glu
            180                 185                 190         
Val Ala Pro Leu Glu Gly Thr Ser Val Cys Gln Ala Val Lys Asn Ser
        195                 200                 205             
Gly Gly Ile Val Val Val Gln Val Glu Arg Val Val Lys Ala Gly Thr
    210                 215                 220                 
Leu Asp Pro Arg His Val Lys Val Pro Gly Ile Tyr Val Asp Tyr Val
225                 230                 235                 240 
Val Val Ala Asp Pro Glu Asp His Gln Gln Ser Leu Asp Cys Glu Tyr
                245                 250                 255     
Asp Pro Ala Leu Ser Gly Glu His Arg Arg Pro Glu Val Val Gly Glu
            260                 265                 270         
Pro Leu Pro Leu Ser Ala Lys Lys Val Ile Gly Arg Arg Gly Ala Ile
        275                 280                 285             
Glu Leu Glu Lys Asp Val Ala Val Asn Leu Gly Val Gly Ala Pro Glu
    290                 295                 300                 
Tyr Val Ala Ser Val Ala Asp Glu Glu Gly Ile Val Asp Phe Met Thr
305                 310                 315                 320 
Leu Thr Ala Glu Ser Gly Ala Ile Gly Gly Val Pro Ala Gly Gly Val
                325                 330                 335     
Arg Phe Gly Ala Ser Tyr Asn Ala Asp Ala Leu Ile Asp Gln Gly Tyr
            340                 345                 350         
Gln Phe Asp Tyr Tyr Asp Gly Gly Gly Leu Asp Leu Cys Tyr Leu Gly
        355                 360                 365             
Leu Ala Glu Cys Asp Glu Lys Gly Asn Ile Asn Val Ser Arg Phe Gly
    370                 375                 380                 
Pro Arg Ile Ala Gly Cys Gly Gly Phe Ile Asn Ile Thr Gln Asn Thr
385                 390                 395                 400 
Pro Lys Val Phe Phe Cys Gly Thr Phe Thr Ala Gly Gly Leu Lys Val
                405                 410                 415     
Lys Ile Glu Asp Gly Lys Val Ile Ile Val Gln Glu Gly Lys Gln Lys
            420                 425                 430         
Lys Phe Leu Lys Ala Val Glu Gln Ile Thr Phe Asn Gly Asp Val Ala
        435                 440                 445             
Leu Ala Asn Lys Gln Gln Val Thr Tyr Ile Thr Glu Arg Cys Val Phe
    450                 455                 460                 
Leu Leu Lys Glu Asp Gly Leu His Leu Ser Glu Ile Ala Pro Gly Ile
465                 470                 475                 480 
Asp Leu Gln Thr Gln Ile Leu Asp Val Met Asp Phe Ala Pro Ile Ile
                485                 490                 495     
Asp Arg Asp Ala Asn Gly Gln Ile Lys Leu Met Asp Ala Ala Leu Phe
            500                 505                 510         
Ala Glu Gly Leu Met Gly Leu Lys Glu Met Lys Ser
        515                 520                 


<210> 5
<211> 517
<212> PRT
<213> Megasphaera elsdenii DSM 20460

<400> 5
Met Arg Lys Val Glu Ile Ile Thr Ala Glu Gln Ala Ala Gln Leu Val
 1               5                  10                  15      
Lys Asp Asn Asp Thr Ile Thr Ser Ile Gly Phe Val Ser Ser Ala His
            20                  25                  30          
Pro Glu Ala Leu Thr Lys Ala Leu Glu Lys Arg Phe Leu Asp Thr Asn
        35                  40                  45              
Thr Pro Gln Asn Leu Thr Tyr Ile Tyr Ala Gly Ser Gln Gly Lys Arg
    50                  55                  60                  
Asp Gly Arg Ala Ala Glu His Leu Ala His Thr Gly Leu Leu Lys Arg
65                  70                  75                  80  
Ala Ile Ile Gly His Trp Gln Thr Val Pro Ala Ile Gly Lys Leu Ala
                85                  90                  95      
Val Glu Asn Lys Ile Glu Ala Tyr Asn Phe Ser Gln Gly Thr Leu Val
            100                 105                 110         
His Trp Phe Arg Ala Leu Ala Gly His Lys Leu Gly Val Phe Thr Asp
        115                 120                 125             
Ile Gly Leu Glu Thr Phe Leu Asp Pro Arg Gln Leu Gly Gly Lys Leu
    130                 135                 140                 
Asn Asp Val Thr Lys Glu Asp Leu Val Lys Leu Ile Glu Val Asp Gly
145                 150                 155                 160 
His Glu Gln Leu Phe Tyr Pro Thr Phe Pro Val Asn Val Ala Phe Leu
                165                 170                 175     
Arg Gly Thr Tyr Ala Asp Glu Ser Gly Asn Ile Thr Met Asp Glu Glu
            180                 185                 190         
Ile Gly Pro Phe Glu Ser Thr Ser Val Ala Gln Ala Val His Asn Cys
        195                 200                 205             
Gly Gly Lys Val Val Val Gln Val Lys Asp Val Val Ala His Gly Ser
    210                 215                 220                 
Leu Asp Pro Arg Met Val Lys Ile Pro Gly Ile Tyr Val Asp Tyr Val
225                 230                 235                 240 
Val Val Ala Ala Pro Glu Asp His Gln Gln Thr Tyr Asp Cys Glu Tyr
                245                 250                 255     
Asp Pro Ser Leu Ser Gly Glu His Arg Ala Pro Glu Gly Ala Thr Asp
            260                 265                 270         
Ala Ala Leu Pro Met Ser Ala Lys Lys Ile Ile Gly Arg Arg Gly Ala
        275                 280                 285             
Leu Glu Leu Thr Glu Asn Ala Val Val Asn Leu Gly Val Gly Ala Pro
    290                 295                 300                 
Glu Tyr Val Ala Ser Val Ala Gly Glu Glu Gly Ile Ala Asp Thr Ile
305                 310                 315                 320 
Thr Leu Thr Val Glu Gly Gly Ala Ile Gly Gly Val Pro Gln Gly Gly
                325                 330                 335     
Ala Arg Phe Gly Ser Ser Arg Asn Ala Asp Ala Ile Ile Asp His Thr
            340                 345                 350         
Tyr Gln Phe Asp Phe Tyr Asp Gly Gly Gly Leu Asp Ile Ala Tyr Leu
        355                 360                 365             
Gly Leu Ala Gln Cys Asp Gly Ser Gly Asn Ile Asn Val Ser Lys Phe
    370                 375                 380                 
Gly Thr Asn Val Ala Gly Cys Gly Gly Phe Pro Asn Ile Ser Gln Gln
385                 390                 395                 400 
Thr Pro Asn Val Tyr Phe Cys Gly Thr Phe Thr Ala Gly Gly Leu Lys
                405                 410                 415     
Ile Ala Val Glu Asp Gly Lys Val Lys Ile Leu Gln Glu Gly Lys Ala
            420                 425                 430         
Lys Lys Phe Ile Lys Ala Val Asp Gln Ile Thr Phe Asn Gly Ser Tyr
        435                 440                 445             
Ala Ala Arg Asn Gly Lys His Val Leu Tyr Ile Thr Glu Arg Cys Val
    450                 455                 460                 
Phe Glu Leu Thr Lys Glu Gly Leu Lys Leu Ile Glu Val Ala Pro Gly
465                 470                 475                 480 
Ile Asp Ile Glu Lys Asp Ile Leu Ala His Met Asp Phe Lys Pro Ile
                485                 490                 495     
Ile Asp Asn Pro Lys Leu Met Asp Ala Arg Leu Phe Gln Asp Gly Pro
            500                 505                 510         
Met Gly Leu Lys Lys
        515         


<210> 6
<211> 497
<212> PRT
<213> Pseudomonas sp. VLB120

<400> 6
Met Leu Cys Glu Leu Pro Ile Leu Pro Ala Thr Arg Ala Phe Leu Glu
 1               5                  10                  15      
Arg Lys Leu Lys Met Arg Ile Gly Ala Asp Trp Gln Asp Ala Ala Ser
            20                  25                  30          
Gly Gln Thr Leu Ser Phe Arg Asn Pro Ala Thr Gly Glu Ile Leu Gly
        35                  40                  45              
Glu Val Pro Ala Ala Asp Ala Thr Asp Val Asp Arg Ala Val Gln Ala
    50                  55                  60                  
Ala Arg Gln Ala Phe Asp Asp Ser Pro Trp Ser Arg Met Arg Pro Arg
65                  70                  75                  80  
Glu Arg Gln Asn Leu Leu Trp Arg Leu Ala Asp Leu Met Glu Arg Asp
                85                  90                  95      
Ala Gln Gln Leu Ala Glu Leu Glu Cys Leu Asn Asn Gly Lys Ser Ala
            100                 105                 110         
Val Val Ala Lys Val Met Asp Val Gln Leu Ala Ile Asp Phe Leu Arg
        115                 120                 125             
Tyr Met Ala Gly Trp Ala Thr Lys Ile Glu Gly Ser Thr Val Glu Ala
    130                 135                 140                 
Ser Met Pro Leu Met Pro Asn Asp Gln Phe His Gly Phe Ile Arg Arg
145                 150                 155                 160 
Glu Ala Val Gly Val Val Gly Ala Ile Val Ala Trp Asn Phe Pro Leu
                165                 170                 175     
Leu Leu Ala Cys Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Cys Thr
            180                 185                 190         
Val Val Leu Lys Pro Ala Asp Glu Thr Pro Leu Thr Ala Leu Lys Leu
        195                 200                 205             
Ala Glu Leu Val Asp Glu Ala Gly Tyr Pro Ala Gly Val Phe Asn Val
    210                 215                 220                 
Val Thr Gly Thr Gly Leu Asn Ala Gly Ala Ala Leu Ser Arg His Pro
225                 230                 235                 240 
Gly Val Asp Lys Leu Thr Phe Thr Gly Ser Thr Glu Val Gly Lys Leu
                245                 250                 255     
Ile Gly Lys Ala Ala Met Asp Asn Met Thr Arg Val Thr Leu Glu Leu
            260                 265                 270         
Gly Gly Lys Ser Pro Thr Ile Val Met Pro Asp Ala Asp Leu Gln Glu
        275                 280                 285             
Ala Ala Ala Gly Ala Ala Thr Ala Ile Phe Phe Asn Gln Gly Gln Val
    290                 295                 300                 
Cys Cys Ala Gly Ser Arg Leu Tyr Val His Arg Lys His Phe Asp Asn
305                 310                 315                 320 
Val Val Ala Asp Ile Ala Gly Ile Ala Asn Gly Met Lys Leu Gly Asn
                325                 330                 335     
Gly Leu Asp Pro Ala Val Gln Met Gly Pro Leu Ile Ser Ala Lys Gln
            340                 345                 350         
Gln Asp Arg Val Thr Gly Tyr Ile Glu Leu Gly Arg Glu Leu Gly Ala
        355                 360                 365             
Thr Ile Ala Cys Gly Gly Glu Gly Phe Gly Pro Gly Tyr Phe Val Lys
    370                 375                 380                 
Pro Thr Val Ile Val Asp Val Asp Gln Arg His Arg Leu Val Gln Glu
385                 390                 395                 400 
Glu Ile Phe Gly Pro Val Leu Val Ala Met Pro Phe Asp Asp Leu Asp
                405                 410                 415     
Glu Val Ile Ala Met Ala Asn Asp Asn Pro Tyr Gly Leu Gly Ala Ser
            420                 425                 430         
Ile Trp Ser Asn Asp Leu Gly Ala Val His Arg Met Ile Pro Arg Ile
        435                 440                 445             
Lys Ser Gly Ser Val Trp Val Asn Cys His Ser Ala Leu Asp Pro Ala
    450                 455                 460                 
Leu Pro Phe Gly Gly Tyr Lys Met Ser Gly Val Gly Arg Glu Met Gly
465                 470                 475                 480 
Ala Ala Ala Ile Glu His Tyr Thr Glu Leu Lys Ser Val Leu Ile Lys
                485                 490                 495     
Leu
    


<210> 7
<211> 385
<212> PRT
<213> Shewanella oneidensis MR-1

<400> 7
Met Asp Phe Asn Phe Asn Glu Asp Gln Arg Gln Phe Ala Glu Leu Ala
 1               5                  10                  15      
Arg Gln Phe Ala Thr Asp Glu Leu Ala Pro Phe Ala Ala Lys Trp Asp
            20                  25                  30          
Glu Glu His His Phe Pro Lys Asp Val Ile Gln Lys Ala Gly Glu Leu
        35                  40                  45              
Gly Phe Cys Ser Leu Tyr Ser Pro Glu Ser Glu Gly Gly Met Gly Leu
    50                  55                  60                  
Ser Arg Leu Asp Ala Ser Ile Ile Phe Glu Glu Leu Ser Lys Gly Cys
65                  70                  75                  80  
Thr Ala Thr Thr Ala Met Leu Thr Ile His Asn Met Ala Thr Trp Met
                85                  90                  95      
Val Thr Thr Trp Gly Thr Glu Thr Leu Arg Gln Ala Trp Ser Glu Pro
            100                 105                 110         
Leu Thr Thr Gly Gln Met Leu Ala Ser Tyr Cys Leu Thr Glu Pro Gly
        115                 120                 125             
Ala Gly Ser Asp Ala Ala Ser Leu Gln Thr Lys Ala Val Pro Asp Gly
    130                 135                 140                 
Asp Glu Tyr Val Val Ser Gly Ser Lys Met Phe Ile Ser Gly Ala Gly
145                 150                 155                 160 
Ser Thr Glu Leu Leu Val Val Met Cys Arg Thr Gly Gln Ala Gly Pro
                165                 170                 175     
Lys Gly Ile Ser Ala Ile Ala Ile Pro Ala Asp Ser Glu Gly Ile Ile
            180                 185                 190         
Tyr Gly Lys Ala Glu Asp Lys Met Gly Trp Asn Ala Gln Pro Thr Arg
        195                 200                 205             
Leu Val Thr Phe Asp Asn Val Arg Val Pro Val Ala Asn Leu Leu Gly
    210                 215                 220                 
Glu Glu Gly Gln Gly Phe Thr Phe Ala Met Lys Gly Leu Asp Gly Gly
225                 230                 235                 240 
Arg Ile Asn Ile Ala Thr Cys Ser Val Gly Thr Ala Gln Ala Ala Leu
                245                 250                 255     
Glu Arg Ala Ser Gln Tyr Met Asn Glu Arg Gln Gln Phe Gly Lys Pro
            260                 265                 270         
Leu Ala Ala Phe Gln Ala Leu Gln Phe Lys Leu Ala Asp Met Ala Thr
        275                 280                 285             
Glu Leu Val Ala Ala Arg Gln Met Val Arg Leu Ala Ala Phe Lys Leu
    290                 295                 300                 
Asp Ser Gly Asp Pro Glu Gly Thr Ala Tyr Cys Ala Met Ala Lys Arg
305                 310                 315                 320 
Phe Ala Thr Asp Val Gly Phe Gln Val Cys Asp Ala Ala Leu Gln Ile
                325                 330                 335     
His Gly Gly Tyr Gly Tyr Ile Arg Glu Tyr Pro Leu Glu Arg His Phe
            340                 345                 350         
Arg Asp Val Arg Val His Gln Ile Leu Glu Gly Thr Asn Glu Ile Met
        355                 360                 365             
Arg Leu Ile Ile Ala Arg Arg Leu Leu Asp Glu Asn Ala Gly Gln Ile
    370                 375                 380                 
Leu
385 


<210> 8
<211> 499
<212> PRT
<213> Escherichia coli

<400> 8
Met Thr Glu Pro His Val Ala Val Leu Ser Gln Val Gln Gln Phe Leu
 1               5                  10                  15      
Asp Arg Gln His Gly Leu Tyr Ile Asp Gly Arg Pro Gly Pro Ala Gln
            20                  25                  30          
Ser Glu Lys Arg Leu Ala Ile Phe Asp Pro Ala Thr Gly Gln Glu Ile
        35                  40                  45              
Ala Ser Thr Ala Asp Ala Asn Glu Ala Asp Val Asp Asn Ala Val Met
    50                  55                  60                  
Ser Ala Trp Arg Ala Phe Val Ser Arg Arg Trp Ala Gly Arg Leu Pro
65                  70                  75                  80  
Ala Glu Arg Glu Arg Ile Leu Leu Arg Phe Ala Asp Leu Val Glu Gln
                85                  90                  95      
His Ser Glu Glu Leu Ala Gln Leu Glu Thr Leu Glu Gln Gly Lys Ser
            100                 105                 110         
Ile Ala Ile Ser Arg Ala Phe Glu Val Gly Cys Thr Leu Asn Trp Met
        115                 120                 125             
Arg Tyr Thr Ala Gly Leu Thr Thr Lys Ile Ala Gly Lys Thr Leu Asp
    130                 135                 140                 
Leu Ser Ile Pro Leu Pro Gln Gly Ala Arg Tyr Gln Ala Trp Thr Arg
145                 150                 155                 160 
Lys Glu Pro Val Gly Val Val Ala Gly Ile Val Pro Trp Asn Phe Pro
                165                 170                 175     
Leu Met Ile Gly Met Trp Lys Val Met Pro Ala Leu Ala Ala Gly Cys
            180                 185                 190         
Ser Ile Val Ile Lys Pro Ser Glu Thr Thr Pro Leu Thr Met Leu Arg
        195                 200                 205             
Val Ala Glu Leu Ala Ser Glu Ala Gly Ile Pro Asp Gly Val Phe Asn
    210                 215                 220                 
Val Val Thr Gly Ser Gly Ala Val Cys Gly Ala Ala Leu Thr Ser His
225                 230                 235                 240 
Pro His Val Ala Lys Ile Ser Phe Thr Gly Ser Thr Ala Thr Gly Lys
                245                 250                 255     
Gly Ile Ala Arg Thr Ala Ala Asp His Leu Thr Arg Val Thr Leu Glu
            260                 265                 270         
Leu Gly Gly Lys Asn Pro Ala Ile Val Leu Lys Asp Ala Asp Pro Gln
        275                 280                 285             
Trp Val Ile Glu Gly Leu Met Thr Gly Ser Phe Leu Asn Gln Gly Gln
    290                 295                 300                 
Val Cys Ala Ala Ser Ser Arg Ile Tyr Ile Glu Ala Pro Leu Phe Asp
305                 310                 315                 320 
Thr Leu Val Ser Gly Phe Glu Gln Ala Val Lys Ser Leu Gln Val Gly
                325                 330                 335     
Pro Gly Met Ser Pro Val Ala Gln Ile Asn Pro Leu Val Ser Arg Ala
            340                 345                 350         
His Cys Asp Lys Val Cys Ser Phe Leu Asp Asp Ala Gln Ala Gln Gln
        355                 360                 365             
Ala Glu Leu Ile Arg Gly Ser Asn Gly Pro Ala Gly Glu Gly Tyr Tyr
    370                 375                 380                 
Val Ala Pro Thr Leu Val Val Asn Pro Asp Ala Lys Leu Arg Leu Thr
385                 390                 395                 400 
Arg Glu Glu Val Phe Gly Pro Val Val Asn Leu Val Arg Val Ala Asp
                405                 410                 415     
Gly Glu Glu Ala Leu Gln Leu Ala Asn Asp Thr Glu Tyr Gly Leu Thr
            420                 425                 430         
Ala Ser Val Trp Thr Gln Asn Leu Ser Gln Ala Leu Glu Tyr Ser Asp
        435                 440                 445             
Arg Leu Gln Ala Gly Thr Val Trp Val Asn Ser His Thr Leu Ile Asp
    450                 455                 460                 
Ala Asn Leu Pro Phe Gly Gly Met Lys Gln Ser Gly Thr Gly Arg Asp
465                 470                 475                 480 
Phe Gly Pro Asp Trp Leu Asp Gly Trp Cys Glu Thr Lys Ser Val Cys
                485                 490                 495     
Val Arg Tyr
            


<210> 9
<211> 386
<212> PRT
<213> Streptomyces avermitilis

<400> 9
Met Asp His Arg Leu Thr Pro Glu Leu Glu Glu Leu Arg Arg Thr Val
 1               5                  10                  15      
Glu Glu Phe Ala His Asp Val Val Ala Pro Lys Ile Gly Asp Phe Tyr
            20                  25                  30          
Glu Arg His Glu Phe Pro Tyr Glu Ile Val Arg Glu Met Gly Arg Met
        35                  40                  45              
Gly Leu Phe Gly Leu Pro Phe Pro Glu Glu Tyr Gly Gly Met Gly Gly
    50                  55                  60                  
Asp Tyr Leu Ala Leu Gly Ile Ala Leu Glu Glu Leu Ala Arg Val Asp
65                  70                  75                  80  
Ser Ser Val Ala Ile Thr Leu Glu Ala Gly Val Ser Leu Gly Ala Met
                85                  90                  95      
Pro Ile His Leu Phe Gly Thr Asp Ala Gln Lys Ala Glu Trp Leu Pro
            100                 105                 110         
Arg Leu Cys Ser Gly Glu Ile Leu Gly Ala Phe Gly Leu Thr Glu Pro
        115                 120                 125             
Asp Gly Gly Ser Asp Ala Gly Ala Thr Arg Thr Thr Ala Arg Leu Asp
    130                 135                 140                 
Glu Ser Thr Asn Glu Trp Val Ile Asn Gly Thr Lys Cys Phe Ile Thr
145                 150                 155                 160 
Asn Ser Gly Thr Asp Ile Thr Gly Leu Val Thr Val Thr Ala Val Thr
                165                 170                 175     
Gly Arg Lys Pro Asp Gly Lys Pro Leu Ile Ser Ser Ile Ile Val Pro
            180                 185                 190         
Ser Gly Thr Pro Gly Phe Thr Val Ala Ala Pro Tyr Ser Lys Val Gly
        195                 200                 205             
Trp Asn Ala Ser Asp Thr Arg Glu Leu Ser Phe Ala Asp Val Arg Val
    210                 215                 220                 
Pro Ala Ala Asn Leu Leu Gly Glu Gln Gly Arg Gly Tyr Ala Gln Phe
225                 230                 235                 240 
Leu Arg Ile Leu Asp Glu Gly Arg Ile Ala Ile Ser Ala Leu Ala Thr
                245                 250                 255     
Gly Leu Ala Gln Gly Cys Val Asp Glu Ser Val Lys Tyr Ala Gly Glu
            260                 265                 270         
Arg His Ala Phe Gly Arg Asn Ile Gly Ala Tyr Gln Ala Ile Gln Phe
        275                 280                 285             
Lys Ile Ala Asp Met Glu Met Lys Ala His Met Ala Arg Val Gly Trp
    290                 295                 300                 
Arg Asp Ala Ala Ser Arg Leu Val Ala Gly Glu Pro Phe Lys Lys Glu
305                 310                 315                 320 
Ala Ala Ile Ala Lys Leu Tyr Ser Ser Thr Val Ala Val Asp Asn Ala
                325                 330                 335     
Arg Glu Ala Thr Gln Ile His Gly Gly Tyr Gly Phe Met Asn Glu Tyr
            340                 345                 350         
Pro Val Ala Arg Met Trp Arg Asp Ser Lys Ile Leu Glu Ile Gly Glu
        355                 360                 365             
Gly Thr Ser Glu Val Gln Arg Met Leu Ile Ala Arg Glu Leu Gly Leu
    370                 375                 380                 
Val Gly
385     

