                         SEQUENCE LISTING

<110>  IMMUNOGEN, INC.
       AB, OLGA
       TAVARES, DANIEL
       SETIADY, JULIANTO
       LADD, SHARRON
       CARRIGAN, CHRISTINA  N
       RUI, LINGYUN
 
<120>  ANTIBODIES AND ASSAYS FOR DETECTION OF FOLATE RECEPTOR 1

<130>  2921.044PC03/EKS/CLD

<140>  To be assigned
<141>  2014-08-29

<150>  61/940,184
<151>  2014-02-14

<150>  61/875,475
<151>  2013-09-09

<150>  61/872,407
<151>  2013-08-30

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  2
<211>  771
<212>  DNA
<213>  Homo sapiens

<400>  2
atggctcagc ggatgacaac acagctgctg ctccttctag tgtgggtggc tgtagtaggg       60

gaggctcaga caaggattgc atgggccagg actgagcttc tcaatgtctg catgaacgcc      120

aagcaccaca aggaaaagcc aggccccgag gacaagttgc atgagcagtg tcgaccctgg      180

aggaagaatg cctgctgttc taccaacacc agccaggaag cccataagga tgtttcctac      240

ctatatagat tcaactggaa ccactgtgga gagatggcac ctgcctgcaa acggcatttc      300

atccaggaca cctgcctcta cgagtgctcc cccaacttgg ggccctggat ccagcaggtg      360

gatcagagct ggcgcaaaga gcgggtactg aacgtgcccc tgtgcaaaga ggactgtgag      420

caatggtggg aagattgtcg cacctcctac acctgcaaga gcaactggca caagggctgg      480

aactggactt cagggtttaa caagtgcgca gtgggagctg cctgccaacc tttccatttc      540

tacttcccca cacccactgt tctgtgcaat gaaatctgga ctcactccta caaggtcagc      600

aactacagcc gagggagtgg ccgctgcatc cagatgtggt tcgacccagc ccagggcaac      660

cccaatgagg aggtggcgag gttctatgct gcagccatga gtggggctgg gccctgggca      720

gcctggcctt tcctgcttag cctggcccta atgctgctgt ggctgctcag c               771


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VH-CDR1

<400>  3

Asn Ser Tyr Ile His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VH-CDR2

<400>  4

Trp Ile Tyr Pro Glu Ser Leu Asn Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VH-CDR3

<400>  5

Arg Gly Ile Tyr Tyr Tyr Ser Pro Tyr Ala Leu Asp His 
1               5                   10              


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VL-CDR1

<400>  6

Lys Ser Ser Lys Ser Leu Leu Asn Ser Asp Gly Phe Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VL-CDR2

<400>  7

Leu Val Ser Asn His Phe Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VL-CDR3

<400>  8

Phe Gln Ser Asn Tyr Leu Pro Leu Thr 
1               5                   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VH-CDR1

<400>  9

Asn Tyr Tyr Ile His 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VH-CDR2

<400>  10

Trp Ile Tyr Pro Gly Ser Phe Asn Val Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VH-CDR3

<400>  11

Arg Gly Ile Tyr Phe Tyr Ser Pro Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VL-CDR1

<400>  12

Lys Ser Thr Glu Ser Leu Leu Asn Ser Asp Gly Phe Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VL-CDR2

<400>  13

Leu Val Ser Asn His Phe Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VL-CDR3

<400>  14

Phe Gln Ser Asn Tyr Leu Pro Leu Thr 
1               5                   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VH-CDR1

<400>  15

Asn Tyr Tyr Ile His 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VH-CDR2

<400>  16

Trp Ile Tyr Pro Glu Asn Val Asn Val Arg Tyr Asn Asp Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VH-CDR3

<400>  17

Arg Gly Ile Tyr Tyr Tyr Ser Pro Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VL-CDR1

<400>  18

Lys Ser Thr Lys Ser Leu Leu Asn Ser Asp Gly Phe Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VL-CDR2

<400>  19

Leu Val Ser Asn His Phe Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VL-CDR3

<400>  20

Phe Gln Ser Asn Tyr Leu Pro Leu Thr 
1               5                   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Composite VH-CDR1


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be tyrosine or serine

<400>  21

Asn Xaa Tyr Ile His 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Composite VH-CDR2


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be glysine or glutamate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be serine or arginine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be phenylalanine or valine or leucine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be valine or threonine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be glutamate or arginine or glutamine

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be glutamate or aspartate

<400>  22

Trp Ile Tyr Pro Xaa Xaa Xaa Asn Xaa Xaa Tyr Asn Xaa Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Composite VH-CDR3


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be phenylalanine or tyrosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be leucine or methionine

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be tyrosine or histidine

<400>  23

Arg Gly Ile Tyr Xaa Tyr Ser Pro Tyr Ala Xaa Asp Xaa 
1               5                   10              


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Composite VL-CDR1


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be threonine or serine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be lycine or glutamate

<400>  24

Lys Ser Xaa Xaa Ser Leu Leu Asn Ser Asp Gly Phe Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Composite VL-CDR2

<400>  25

Leu Val Ser Asn His Phe Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Composite VL-CDR3

<400>  26

Phe Gln Ser Asn Tyr Leu Pro Leu Thr 
1               5                   


<210>  27
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VH Chain

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser 
            20                  25                  30          


Tyr Ile His Trp Val Lys Lys Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Ser Leu Asn Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Tyr Tyr Tyr Ser Pro Tyr Ala Leu Asp His Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  28
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VL Chain

<400>  28

Ser Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile 
1               5                   10                  15      


Gly Asp Gln Ala Ser Ile Ser Cys Lys Ser Ser Lys Ser Leu Leu Asn 
            20                  25                  30          


Ser Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln 
                85                  90                  95      


Ser Asn Tyr Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  29
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VH Chain

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Phe Asn Val Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Tyr Phe Tyr Ser Pro Tyr Ala Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  30
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VL Chain

<400>  30

Ser Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile 
1               5                   10                  15      


Gly Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Glu Ser Leu Leu Asn 
            20                  25                  30          


Ser Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln 
                85                  90                  95      


Ser Asn Tyr Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Val 
            100                 105                 110         


Lys Arg 
        


<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VH Chain

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Val Asn Val Arg Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Tyr Tyr Tyr Ser Pro Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VL Chain

<400>  32

Ser Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Leu 
1               5                   10                  15      


Gly Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn 
            20                  25                  30          


Ser Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln 
                85                  90                  95      


Ser Asn Tyr Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  33
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 Full-Length Heavy Chain

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser 
            20                  25                  30          


Tyr Ile His Trp Val Lys Lys Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Ser Leu Asn Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Tyr Tyr Tyr Ser Pro Tyr Ala Leu Asp His Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Glu Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Met Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  34
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 Full-length Light Chain

<400>  34

Ser Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile 
1               5                   10                  15      


Gly Asp Gln Ala Ser Ile Ser Cys Lys Ser Ser Lys Ser Leu Leu Asn 
            20                  25                  30          


Ser Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln 
                85                  90                  95      


Ser Asn Tyr Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
145                 150                 155                 160 


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
            180                 185                 190         


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
        195                 200                 205             


Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 220 


<210>  35
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 Full-Length Heavy Chain

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Phe Asn Val Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Tyr Phe Tyr Ser Pro Tyr Ala Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Glu Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Met Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  36
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 Full-Length Light Chain

<400>  36

Ser Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile 
1               5                   10                  15      


Gly Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Glu Ser Leu Leu Asn 
            20                  25                  30          


Ser Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln 
                85                  90                  95      


Ser Asn Tyr Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Val 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
145                 150                 155                 160 


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
            180                 185                 190         


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
        195                 200                 205             


Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 220 


<210>  37
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 Full-Length Heavy Chain

<400>  37

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Val Asn Val Arg Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Tyr Tyr Tyr Ser Pro Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Glu Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Met Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  38
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 Full-Length Light Chain

<400>  38

Ser Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Leu 
1               5                   10                  15      


Gly Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn 
            20                  25                  30          


Ser Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln 
                85                  90                  95      


Ser Asn Tyr Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
145                 150                 155                 160 


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
            180                 185                 190         


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
        195                 200                 205             


Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 220 


<210>  39
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VH Chain

<400>  39
caggtccaac tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca aactcctata ttcactgggt gaaaaagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg aaagtcttaa tactcaatac      180

aatgagaagt tcaaggccaa ggccacactg actgctgaca agtcctccag cacatcctac      240

atgcagctca gcagtctgac ctctgaggac tctgcggtct atttctgtgc aagaaggggt      300

atttattact actctcccta tgctctggac cactggggtc aaggagcctc agtcaccgtc      360

tcctca                                                                 366


<210>  40
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muFRIHC2-1 VL Chain

<400>  40
agtgatgttg ttctgaccca aactccactc tctctgcctg tcaatattgg agatcaagcc       60

tctatctctt gcaagtcttc taagagtctt ctgaatagtg atggattcac ttatttggac      120

tggtacctgc agaagccagg ccagtctcca cagctcctaa tatatttggt ttctaatcat      180

ttttctggag ttccagacag gttcagtggc agtgggtcag gaacagattt cacactcaag      240

atcagcagag tggaggctga ggatttggga gtttattatt gcttccagag taactatctt      300

cctctcacgt tcggaggggg gaccaagctg gaaataaaac gg                         342


<210>  41
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VH Chain

<400>  41
caggtccaac tgcagcagtc tggacctgag gtggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca aactactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaagttttaa tgttgagtac      180

aatgagaagt tcaaggccaa ggccacactg actgcagaca aatcctccag cacagtctac      240

atgcaactca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagaaggggt      300

atttatttct actctcccta tgctttggac tactggggtc aaggagcctc agtcaccgtc      360

tcctca                                                                 366


<210>  42
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muFRIHC5-7 VL Chain

<400>  42
agtgatgttg ttctgaccca aactccactc tctctgcctg tcaatattgg agatcaagcc       60

tctatctctt gcaagtctac tgagagtctt ctgaatagtg atggattcac ttatttggac      120

tggtacctgc agaagccagg ccagtctcca cagctcctaa tatatttggt ttctaatcat      180

ttttctggag ttccagacag gttcagtggc agtgggtcag gaacagattt cacactcaag      240

atcagcagag tggaggctga ggatttggga gtttattatt gcttccagag taactatctt      300

cctctcacgt tcggaggggg gaccaagctg gaagtaaaac gg                         342


<210>  43
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VH Chain

<400>  43
caggtccaac tgcagcagtc tggacctgac ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggctt caccttcaca aactactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg aaaatgttaa tgttaggtac      180

aatgacaagt tcaaggccaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagaaggggt      300

atttattact actctcccta tgctatggac tactggggtc aaggagcctc agtcaccgtc      360

tcctca                                                                 366


<210>  44
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muFRIHC9-20 VL Chain

<400>  44
agtgatgttg ttctgaccca aactccactc tctctgcctg tcaatcttgg agatcaagcc       60

tctatctctt gcaagtctac taagagtctt ctgaatagtg atggattcac ttatttggac      120

tggtacctgc agaagccagg ccagtctcca cagctcctaa tatatttggt ttctaatcat      180

ttttctggag ttccagacag gttcagtggc agtgggtcag gaacagattt caccctcaag      240

atcagcagag tggaggctga ggatttggga gtttattatt gcttccagag taactatctt      300

cctctcacgt tcggaggggg gaccaagctg gaaataaaac gg                         342


<210>  45
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  46
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLCv1.00

<400>  46

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  47
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLCv1.60

<400>  47

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLC CDR1

<400>  48

Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr Ser Leu Met His 
1               5                   10                  15  


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLC CDR2

<400>  49

Arg Ala Ser Asn Leu Glu Ala 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vLC CDR3

<400>  50

Gln Gln Ser Arg Glu Tyr Pro Tyr Thr 
1               5                   


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC CDR1

<400>  51

Gly Tyr Phe Met Asn 
1               5   


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC CDR2 - Kabat Defined

<400>  52

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC CDR2 - Abm Defined

<400>  53

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe 
1               5                   10  


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 vHC CDR3

<400>  54

Tyr Asp Gly Ser Arg Ala Met Asp Tyr 
1               5                   


<210>  55
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 HC amino acid sequence

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  56
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 LCv1.00

<400>  56

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  57
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMov19 LCv1.60

<400>  57

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMov19 vHC CDR2 - Kabat Defined

<400>  58

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRIHC2-1 Resurfaced or Grafted Light Chain v1.0 CDR1

<400>  59

Arg Ser Ser Arg Ser Leu Leu Asn Ser Asp Gly Phe Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRIHC2-1 Resurfaced Heavy Chain CDR2

<400>  60

Trp Ile Tyr Pro Glu Ser Leu Asn Thr Gln 
1               5                   10  


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRIHC2-1 Resurfaced HC CDR2

<400>  61

Trp Ile Tyr Pro Glu Ser Leu Asn Thr Gln Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 (resurfaced) VH Chain

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser 
            20                  25                  30          


Tyr Ile His Trp Val Lys Lys Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Ser Leu Asn Thr Gln Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Tyr Tyr Tyr Ser Pro Tyr Ala Leu Asp His Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  63
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 v. 1.0 (resurfaced) VL Chain

<400>  63

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Asn Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  64
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 v. 1.01 (resurfaced) VL Chain

<400>  64

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Asn Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  65
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 (grafted) VH Chain

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Ser Leu Asn Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ala Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Tyr Tyr Tyr Ser Pro Tyr Ala Leu Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125 


<210>  66
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 v. 1.0 (grafted) VL Chain

<400>  66

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  67
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 v. 1.01 (grafted) VL Chain

<400>  67

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn His Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  68
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muhuMov19 Full-Length Heavy Chain

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Glu 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Met 
            180                 185                 190         


Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
    210                 215                 220                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
305                 310                 315                 320 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            340                 345                 350         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        355                 360                 365             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe 
385                 390                 395                 400 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                405                 410                 415     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440         


<210>  69
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muhuMov19 Full-Length Light Chain

<400>  69

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
        115                 120                 125             


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
145                 150                 155                 160 


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
            180                 185                 190         


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
        195                 200                 205             


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215             


<210>  70
<211>  452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 (resurfaced) VH Chain

<400>  70
aagcttgcca ccatgggttg gagctgcatt atccttttcc ttgtggctac agctactggc       60

gttcactctc aggtacaatt ggttcagtca ggagccgagg tcgtaaagcc cggtgccagt      120

gtgaagatct catgcaaggc aagcggttat acttttacaa actcttacat tcattgggtg      180

aaaaagcggc ccggccaggg tctcgaatgg atcggctgga tctacccaga aagtctgaac      240

actcaataca accagaagtt tcagggtaag gcaactctca ctgccgacaa gagctctagc      300

acaagctata tgcagttgtc tagtttgaca agcgaggata gcgcagttta cttttgtgct      360

cggcgtggta tttattacta ctcaccttat gctctggatc actggggaca gggtgcctct      420

gttaccgttt ccagtgcatc caccaagggc cc                                    452


<210>  71
<211>  452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 (grafted) VH Chain

<400>  71
aagcttgcca ccatgggctg gagctgcata atcctcttcc tcgtagctac cgccactggg       60

gtgcattctc aagtacagtt ggtgcagtcc ggagctgaag tcaagaagcc aggggcttct      120

gttaaggtga gctgtaaggc ttccggatat accttcacaa acagttatat ccattgggtg      180

aggcaagctc caggccaggg tctcgaatgg atgggatgga tctaccccga gagtctgaac      240

acccagtaca acgagaagtt caaggcacgt gtgaccatga caagagacac ctccatcagt      300

acagcctata tggaattgag ccgtctcaga agtgatgata cagcagtgta ctactgcgcc      360

aggcggggca tctactacta cagcccatac gctctcgacc actggggaca aggaacactg      420

gtaaccgtaa gctcagcttc tacaaagggc cc                                    452


<210>  72
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 v. 1.0 (resurfaced) VL Chain

<400>  72
gaattcgcca ccatgggttg gtcatgtata atacttttcc tggtagctac tgctactggt       60

gtgcattcag atgtggtgct gactcagtca cccttgtctc tcccagtcaa tcttgggcag      120

ccagcatcta tcagctgccg aagcagcagg tctctcctga actccgatgg ctttacttat      180

cttgactggt atctccagaa gccaggacag tccccccggc tgctcatcta cctggtttct      240

aatcatttta gtggcgtccc tgaccgcttc tctgggagtg gaagtgggac cgattttaca      300

ctgaagatct ccagggtcga agctgaggac cttggggttt actactgttt ccagagcaac      360

taccttccct tgacattcgg ccagggaacc aagctggaaa tcaagcgtac g               411


<210>  73
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 v. 1.01 (resurfaced) VL Chain

<400>  73
gaattcgcca ccatgggttg gtcttgtatc attctgttcc tggtcgccac tgccacagga       60

gttcactcag acgtggtact cacacaatct cccctttccc tgcctgtgaa cctgggacag      120

ccagcctcaa tcagttgcaa gagctctaaa tctctgctca atagcgatgg ctttacctac      180

ttggattggt acctccagaa gcccggccag tctcctcggc tcctgattta ccttgtttca      240

aatcactttt caggcgtgcc tgaccggttc tccggatctg gctcagggac agacttcacc      300

ctgaagatct cccgcgtcga ggcagaggat ctcggcgtgt attactgttt ccaaagtaac      360

tacctgccat tgacttttgg acaaggaact aaactggaaa tcaaacgtac g               411


<210>  74
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 v. 1.0 (grafted) VL Chain

<400>  74
gaattcgcca ccatgggatg gagttgtatt attctgttct tggtcgctac tgcaacaggc       60

gttcattctg acatcgtaat gacccagaca cctctgagtc tgagtgtcac tcccggccag      120

cccgcctcta tttcatgtcg tagctctcgc tccctgctca attccgacgg ttttacctac      180

ttggactggt atcttcagaa acctgggcag agccctcagc ttctgatcta tctggtgtcc      240

aatcacttca gtggcgtccc agaccgattt tccggaagcg gaagcggaac cgactttacc      300

ctgaagatat cccgcgtcga agcagaggac gtgggcgtgt attattgctt tcaaagcaat      360

tacttgccat tgactttcgg acaaggcaca aaactggaga ttaagcgtac g               411


<210>  75
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFRIHC2-1 v. 1.01 (grafted) VL Chain

<400>  75
gaattcgcca ccatgggctg gtcatgcatc atactgttcc tggtggctac agcaaccggg       60

gtgcacagcg atattgttat gacacagaca ccactgagtt tgtcagtgac ccccggccag      120

ccagcctcta tatcctgcaa gtcctcaaaa agtctcctga atagcgatgg ctttacctac      180

ctcgactggt atcttcagaa gcccggtcaa agccctcagc tgctgatata tctggtgtct      240

aaccatttta gcggagtccc cgaccgcttt tcaggctccg gcagtggcac cgacttcacc      300

cttaagattt ctcgcgtgga ggctgaagat gtaggggtct actactgttt ccagtcaaac      360

tacctgccac tgacctttgg tcaaggcact aagctcgaaa ttaagcgtac g               411


